Result of FASTA (omim) for
pF1KB6831
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6831, 166 aa
1>>>pF1KB6831 166 - 166 aa - 166 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.6140+/-0.000319; mu= 7.3447+/- 0.020
mean_var=125.5107+/-24.736, 0's: 0 Z-trim(119.9): 64 B-trim: 325 in 1/53
Lambda= 0.114481
statistics sampled from 34326 (34391) to 34326 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.761), E-opt: 0.2 (0.403), width: 16
Scan time: 6.130
The best scores are: opt bits E(85289)
NP_006151 (OMIM: 601725) neurogenic differentiatio ( 382) 258 53.0 6e-07
NP_835455 (OMIM: 607194,609069,615935) pancreas tr ( 328) 251 51.8 1.2e-06
NP_067014 (OMIM: 611635) neurogenic differentiatio ( 331) 228 48.0 1.7e-05
NP_002491 (OMIM: 125853,601724,606394) neurogenic ( 356) 225 47.5 2.5e-05
NP_073565 (OMIM: 611513) neurogenic differentiatio ( 337) 223 47.2 3e-05
NP_005163 (OMIM: 601461) protein atonal homolog 1 ( 354) 221 46.9 3.9e-05
NP_660161 (OMIM: 609875) protein atonal homolog 7 ( 152) 195 42.3 0.00041
NP_006152 (OMIM: 601726) neurogenin-1 [Homo sapien ( 237) 196 42.6 0.00051
NP_005589 (OMIM: 162360) helix-loop-helix protein ( 133) 189 41.2 0.00073
NP_001104531 (OMIM: 162361) helix-loop-helix prote ( 135) 189 41.2 0.00074
NP_005590 (OMIM: 162361) helix-loop-helix protein ( 135) 189 41.2 0.00074
NP_001157877 (OMIM: 607539,609432,615416) class A ( 235) 191 41.8 0.00089
NP_004600 (OMIM: 601010) transcription factor 15 [ ( 199) 189 41.4 0.00099
NP_000465 (OMIM: 101400,123100,180750,601622) twis ( 202) 185 40.7 0.0016
XP_011513798 (OMIM: 101400,123100,180750,601622) P ( 202) 185 40.7 0.0016
NP_476527 (OMIM: 200110,209885,227260,607556) twis ( 160) 182 40.1 0.0019
NP_001258822 (OMIM: 200110,209885,227260,607556) t ( 160) 182 40.1 0.0019
XP_016871769 (OMIM: 604882,610370) PREDICTED: neur ( 214) 180 39.9 0.0029
NP_066279 (OMIM: 604882,610370) neurogenin-3 [Homo ( 214) 180 39.9 0.0029
NP_542173 (OMIM: 609331) class E basic helix-loop- ( 241) 180 40.0 0.0032
XP_006716679 (OMIM: 609067) PREDICTED: basic helix ( 201) 178 39.6 0.0035
NP_001073983 (OMIM: 609067) basic helix-loop-helix ( 201) 178 39.6 0.0035
NP_076924 (OMIM: 606624) neurogenin-2 [Homo sapien ( 272) 178 39.7 0.0044
NP_005412 (OMIM: 186855,613065) T-cell acute lymph ( 108) 167 37.5 0.0077
>>NP_006151 (OMIM: 601725) neurogenic differentiation fa (382 aa)
initn: 226 init1: 226 opt: 258 Z-score: 245.7 bits: 53.0 E(85289): 6e-07
Smith-Waterman score: 261; 41.5% identity (61.2% similar) in 147 aa overlap (34-164:43-184)
10 20 30 40 50 60
pF1KB6 YPESCVDTTVLDFVADLSLASPRRPLLCDFAPGVSLGDPALALREGRPRRMARFEEGDPE
::: . :: : ..: . : :::
NP_006 SDVPKFASWGDGEDDEPRSDKGDAPPPPPPAPGPGAPGPA---RAAKPVPL-RGEEGTEA
20 30 40 50 60
70 80 90 100
pF1KB6 -----EEECEVDQGDGEEEEEEERGRGVSLLGRPKR----KRVITYAQ-------RQAAN
.:: :. :. :::::::.: . :::. :: .: :. :: ::
NP_006 TLAEVKEEGELG-GEEEEEEEEEEGLDEAEGERPKKRGPKKRKMTKARLERSKLRRQKAN
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB6 IRERKRMFNLNEAFDQLRRKVPTFAYEKRLSRIETLRLAIVYISFMTELLESCEKKESG
:::.:: .:: :.:.::. :: .. ..::.::::::: :: ..:.:.: .. .
NP_006 ARERNRMHDLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSGKRPDLVS
130 140 150 160 170 180
NP_006 YVQTLCKGLSQPTTNLVAGCLQLNSRNFLTEQGADGAGRFHGSGGPFAMHPYPYPCSRLA
190 200 210 220 230 240
>>NP_835455 (OMIM: 607194,609069,615935) pancreas transc (328 aa)
initn: 239 init1: 239 opt: 251 Z-score: 240.4 bits: 51.8 E(85289): 1.2e-06
Smith-Waterman score: 251; 49.4% identity (79.5% similar) in 83 aa overlap (82-159:139-221)
60 70 80 90 100
pF1KB6 RRMARFEEGDPEEEECEVDQGDGEEEEEEERG-RGVSLLGRPKRKRVITYAQ----RQAA
:: :.. . .:.:: . :. ::::
NP_835 GGFPYSPGSPPSCLAYPCAGAAVLSPGARLRGLSGAAAAAARRRRRVRSEAELQQLRQAA
110 120 130 140 150 160
110 120 130 140 150 160
pF1KB6 NIRERKRMFNLNEAFDQLRRKVPTFAYEKRLSRIETLRLAIVYISFMTELLESCEKKESG
:.:::.:: ..:.::. :: ..::. ::::::...:::::: ::.:..::...
NP_835 NVRERRRMQSINDAFEGLRSHIPTLPYEKRLSKVDTLRLAIGYINFLSELVQADLPLRGG
170 180 190 200 210 220
NP_835 GAGGCGGPGGGGRLGGDSPGSQAQKVIICHRGTRSPSPSDPDYGLPPLAGHSLSWTDEKQ
230 240 250 260 270 280
>>NP_067014 (OMIM: 611635) neurogenic differentiation fa (331 aa)
initn: 293 init1: 209 opt: 228 Z-score: 219.8 bits: 48.0 E(85289): 1.7e-05
Smith-Waterman score: 228; 45.8% identity (67.7% similar) in 96 aa overlap (75-164:56-150)
50 60 70 80 90
pF1KB6 ALREGRPRRMARFEEGDPEEEECEVDQGDGEEEEEEERGRGVSLLGRPKRKRVIT-----
::::::: :. . : ::.:..
NP_067 GSQNEVKEEESRPGTYGMLSSLTEEHDSIEEEEEEEEDGEKPKRRG-PKKKKMTKARLER
30 40 50 60 70 80
100 110 120 130 140 150
pF1KB6 -YAQRQAANIRERKRMFNLNEAFDQLRRKVPTFAYEKRLSRIETLRLAIVYISFMTELLE
:.: :: ::: :: .::.:.:.::: .: .. ..::.::::::: :: ..:.::
NP_067 FRARRVKANARERTRMHGLNDALDNLRRVMPCYSKTQKLSKIETLRLARNYIWALSEVLE
90 100 110 120 130 140
160
pF1KB6 SCEKKESG
. . :
NP_067 TGQTPEGKGFVEMLCKGLSQPTSNLVAGCLQLGPQSVLLEKHEDKSPICDSAISVHNFNY
150 160 170 180 190 200
>>NP_002491 (OMIM: 125853,601724,606394) neurogenic diff (356 aa)
initn: 196 init1: 196 opt: 225 Z-score: 216.7 bits: 47.5 E(85289): 2.5e-05
Smith-Waterman score: 225; 43.6% identity (68.2% similar) in 110 aa overlap (57-159:53-159)
30 40 50 60 70 80
pF1KB6 RPLLCDFAPGVSLGDPALALREGRPRRMARFEEGDPEEEECEVDQGDGEEEEEEERGRGV
...: ::.: : : . ::::::. .
NP_002 TDECLSSQDEEHEADKKEDDLEAMNAEEDSLRNGGEEEDEDE-DLEEEEEEEEEDDDQKP
30 40 50 60 70 80
90 100 110 120 130
pF1KB6 SLLGRPKRKRVITYAQ-------RQAANIRERKRMFNLNEAFDQLRRKVPTFAYEKRLSR
. : ::.:. .: :. :. :: :::.:: .:: :.:.::. :: .. ..::.
NP_002 KRRG-PKKKK-MTKARLERFKLRRMKANARERNRMHGLNAALDNLRKVVPCYSKTQKLSK
90 100 110 120 130
140 150 160
pF1KB6 IETLRLAIVYISFMTELLESCEKKESG
::::::: :: ..:.:.:
NP_002 IETLRLAKNYIWALSEILRSGKSPDLVSFVQTLCKGLSQPTTNLVAGCLQLNPRTFLPEQ
140 150 160 170 180 190
>>NP_073565 (OMIM: 611513) neurogenic differentiation fa (337 aa)
initn: 229 init1: 177 opt: 223 Z-score: 215.2 bits: 47.2 E(85289): 3e-05
Smith-Waterman score: 223; 42.2% identity (63.8% similar) in 116 aa overlap (44-157:41-150)
20 30 40 50 60 70
pF1KB6 LDFVADLSLASPRRPLLCDFAPGVSLGDPALALREGRPRRMARFEEGDPEEEECEVDQGD
..:: :. . : :: . :::: :
NP_073 VMPESQMCRKFSRECEDQKQIKKPESFSKQIVLR-GKSIKRAPGEETEKEEEE-----ED
20 30 40 50 60
80 90 100 110 120 130
pF1KB6 GEEEEEE--ERGRGVSLLGRPKRKRVITYAQRQAANIRERKRMFNLNEAFDQLRRKVPTF
:::.:. : ::. : . . .:: :: :::.:: .::.:.:.::. :: .
NP_073 REEEDENGLPRRRGLRKKKTTKLRLERVKFRRQEANARERNRMHGLNDALDNLRKVVPCY
70 80 90 100 110 120
140 150 160
pF1KB6 AYEKRLSRIETLRLAIVYISFMTELLESCEKKESG
. ..::.::::::: :: ..:.:
NP_073 SKTQKLSKIETLRLAKNYIWALSEILRIGKRPDLLTFVQNLCKGLSQPTTNLVAGCLQLN
130 140 150 160 170 180
>>NP_005163 (OMIM: 601461) protein atonal homolog 1 [Hom (354 aa)
initn: 224 init1: 206 opt: 221 Z-score: 213.1 bits: 46.9 E(85289): 3.9e-05
Smith-Waterman score: 221; 46.8% identity (72.7% similar) in 77 aa overlap (85-159:141-217)
60 70 80 90 100 110
pF1KB6 ARFEEGDPEEEECEVDQGDGEEEEEEERGRGVSLLGRPKRKRV--ITYAQRQAANIRERK
: : :. :.: . .: ::: :::.
NP_005 GGASSSKSPGPVKVREQLCKLKGGVVVDELGCSRQRAPSSKQVNGVQKQRRLAANARERR
120 130 140 150 160 170
120 130 140 150 160
pF1KB6 RMFNLNEAFDQLRRKVPTFAYEKRLSRIETLRLAIVYISFMTELLESCEKKESG
:: .::.:::::: .:.: .:.::. :::..: .::. ..:::..
NP_005 RMHGLNHAFDQLRNVIPSFNNDKKLSKYETLQMAQIYINALSELLQTPSGGEQPPPPPAS
180 190 200 210 220 230
NP_005 CKSDHHHLRTAASYEGGAGNATAAGAQQASGGSQRPTPPGSCRTRFSAPASAGGYSVQLD
240 250 260 270 280 290
>>NP_660161 (OMIM: 609875) protein atonal homolog 7 [Hom (152 aa)
initn: 179 init1: 179 opt: 195 Z-score: 194.9 bits: 42.3 E(85289): 0.00041
Smith-Waterman score: 195; 50.8% identity (77.0% similar) in 61 aa overlap (102-162:41-101)
80 90 100 110 120 130
pF1KB6 GDGEEEEEEERGRGVSLLGRPKRKRVITYAQRQAANIRERKRMFNLNEAFDQLRRKVPTF
.: ::: :::.:: .:: :::.::: :: .
NP_660 AGARVAPPCAGGTECAGTCAGAGRLESAARRRLAANARERRRMQGLNTAFDRLRRVVPQW
20 30 40 50 60 70
140 150 160
pF1KB6 AYEKRLSRIETLRLAIVYISFMTELLESCEKKESG
. .:.::. :::..:. :: .:..: :.
NP_660 GQDKKLSKYETLQMALSYIMALTRILAEAERFGSERDWVGLHCEHFGRDHYLPFPGAKLP
80 90 100 110 120 130
NP_660 GESELYSQRLFGFQPEPFQMAT
140 150
>>NP_006152 (OMIM: 601726) neurogenin-1 [Homo sapiens] (237 aa)
initn: 188 init1: 159 opt: 196 Z-score: 193.2 bits: 42.6 E(85289): 0.00051
Smith-Waterman score: 203; 31.3% identity (53.6% similar) in 166 aa overlap (1-166:1-157)
10 20 30 40 50 60
pF1KB6 MAAYPESCVDTTVLDFVADLSLASPRRPLLCDFAPGVSLGDPALALREGRPRRMARFEEG
: : :.:.. :: .. : .: .: : . : . : : : : .:
NP_006 MPARLETCISD--LDCAS--SSGSDLSGFLTDEEDCARLQQAASASGPPAPAR-----RG
10 20 30 40 50
70 80 90 100 110 120
pF1KB6 DPEEEECEVDQGDGEEEEEEERGRGVSLLGRPKRKRVITYAQRQAANIRERKRMFNLNEA
:. . : ..:.:..: :: . . . . ..: :: :::.:: ::: :
NP_006 APNISRASEVPGAQDDEQERRRRRGRTRVRSEALLHSLRRSRRVKANDRERNRMHNLNAA
60 70 80 90 100 110
130 140 150 160
pF1KB6 FDQLRRKVPTFAYEKRLSRIETLRLAIVYISFMTELLESCEKKESG
.: :: .:.: . .:..:::::.: :: ..: :. .. :
NP_006 LDALRSVLPSFPDDTKLTKIETLRFAYNYIWALAETLRLADQGLPGGGARERLLPPQCVP
120 130 140 150 160 170
NP_006 CLPGPPSPASDAESWGSGAAAASPLSDPSSPAASEDFTYRPGDPVFSFPSLPKDLLHTTP
180 190 200 210 220 230
>>NP_005589 (OMIM: 162360) helix-loop-helix protein 1 [H (133 aa)
initn: 183 init1: 157 opt: 189 Z-score: 190.4 bits: 41.2 E(85289): 0.00073
Smith-Waterman score: 189; 41.1% identity (65.6% similar) in 90 aa overlap (71-158:44-132)
50 60 70 80 90
pF1KB6 DPALALREGRPRRMARFEEGDPEEEECEVDQGDGEEEEEEERGRGVSLLGRP--KRKRVI
:. : : : : . .. :.: .:.:
NP_005 PTHSETESGFSDCGGGAGPDGAGPGGPGGGQARGPEPGEPGR-KDLQHLSREERRRRRRA
20 30 40 50 60 70
100 110 120 130 140 150
pF1KB6 TYAQRQAANIRERKRMFNLNEAFDQLRRKVPTFAYEKRLSRIETLRLAIVYISFMTELLE
: : : ::: :. .: :: .::. .::. .:.::.:: ::::: :::.....:.
NP_005 TAKYRTAHATRERIRVEAFNLAFAELRKLLPTLPPDKKLSKIEILRLAICYISYLNHVLD
80 90 100 110 120 130
160
pF1KB6 SCEKKESG
NP_005 V
>>NP_001104531 (OMIM: 162361) helix-loop-helix protein 2 (135 aa)
initn: 192 init1: 157 opt: 189 Z-score: 190.3 bits: 41.2 E(85289): 0.00074
Smith-Waterman score: 189; 32.4% identity (56.8% similar) in 139 aa overlap (22-158:2-134)
10 20 30 40 50 60
pF1KB6 MAAYPESCVDTTVLDFVADLSLASPRRPLLCDFAPGVSLGDPALALREGRPRRMARFEEG
. :: . : :. . .:: .: . .. .
NP_001 MMLSPDQAADSDH-PSSAHSDPE-SLGGTDTKVLGSVSDL
10 20 30
70 80 90 100 110
pF1KB6 DPEEEECEVDQGDGEEEEEEERGRGVSLLGRP--KRKRVITYAQRQAANIRERKRMFNLN
.: :: .:::. . . :.: .:.: : :.: ::: :. .:
NP_001 EPVEEA----EGDGKGGSRAALYPHPQQLSREEKRRRRRATAKYRSAHATRERIRVEAFN
40 50 60 70 80 90
120 130 140 150 160
pF1KB6 EAFDQLRRKVPTFAYEKRLSRIETLRLAIVYISFMTELLESCEKKESG
:: .::. .::. .:.::.:: ::::: :::.....:.
NP_001 LAFAELRKLLPTLPPDKKLSKIEILRLAICYISYLNHVLDV
100 110 120 130
166 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 04:07:24 2016 done: Sat Nov 5 04:07:25 2016
Total Scan time: 6.130 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]