FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6839, 172 aa 1>>>pF1KB6839 172 - 172 aa - 172 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.7559+/-0.00031; mu= 15.3319+/- 0.019 mean_var=58.2214+/-11.442, 0's: 0 Z-trim(115.5): 25 B-trim: 0 in 0/54 Lambda= 0.168087 statistics sampled from 26000 (26025) to 26000 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.7), E-opt: 0.2 (0.305), width: 16 Scan time: 4.980 The best scores are: opt bits E(85289) NP_006694 (OMIM: 609228) diphosphoinositol polypho ( 172) 1137 283.5 1.2e-76 NP_061967 (OMIM: 609229) diphosphoinositol polypho ( 180) 845 212.7 2.5e-55 NP_950241 (OMIM: 609229) diphosphoinositol polypho ( 181) 833 209.8 1.9e-54 NP_060629 (OMIM: 300528) diphosphoinositol polypho ( 164) 818 206.1 2.2e-53 NP_694853 (OMIM: 300527) diphosphoinositol polypho ( 164) 808 203.7 1.2e-52 NP_001291892 (OMIM: 300527) diphosphoinositol poly ( 164) 808 203.7 1.2e-52 XP_011536097 (OMIM: 609229) PREDICTED: diphosphoin ( 128) 539 138.4 4.2e-33 NP_001287953 (OMIM: 609229) diphosphoinositol poly ( 128) 539 138.4 4.2e-33 NP_001287952 (OMIM: 609229) diphosphoinositol poly ( 128) 539 138.4 4.2e-33 XP_011536098 (OMIM: 609229) PREDICTED: diphosphoin ( 128) 539 138.4 4.2e-33 XP_011536096 (OMIM: 609229) PREDICTED: diphosphoin ( 129) 527 135.5 3.2e-32 NP_001287951 (OMIM: 609229) diphosphoinositol poly ( 129) 527 135.5 3.2e-32 NP_009014 (OMIM: 606261) nucleoside diphosphate-li ( 316) 143 42.6 0.0007 NP_671701 (OMIM: 602852) NUDT2 gene product [Homo ( 147) 134 40.2 0.0017 NP_671702 (OMIM: 602852) NUDT2 gene product [Homo ( 147) 134 40.2 0.0017 NP_001152 (OMIM: 602852) NUDT2 gene product [Homo ( 147) 134 40.2 0.0017 NP_001231319 (OMIM: 602852) NUDT2 gene product [Ho ( 147) 134 40.2 0.0017 NP_932158 (OMIM: 606261) nucleoside diphosphate-li ( 147) 129 39.0 0.004 >>NP_006694 (OMIM: 609228) diphosphoinositol polyphospha (172 aa) initn: 1137 init1: 1137 opt: 1137 Z-score: 1497.2 bits: 283.5 E(85289): 1.2e-76 Smith-Waterman score: 1137; 100.0% identity (100.0% similar) in 172 aa overlap (1-172:1-172) 10 20 30 40 50 60 pF1KB6 MMKLKSNQTRTYDGDGYKKRAACLCFRSESEEEVLLVSSSRHPDRWIVPGGGMEPEEEPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MMKLKSNQTRTYDGDGYKKRAACLCFRSESEEEVLLVSSSRHPDRWIVPGGGMEPEEEPS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 VAAVREVCEEAGVKGTLGRLVGIFENQERKHRTYVYVLIVTEVLEDWEDSVNIGRKREWF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VAAVREVCEEAGVKGTLGRLVGIFENQERKHRTYVYVLIVTEVLEDWEDSVNIGRKREWF 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 KIEDAIKVLQYHKPVQASYFETLRQGYSANNGTPVVATTYSVSAQSSMSGIR :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 KIEDAIKVLQYHKPVQASYFETLRQGYSANNGTPVVATTYSVSAQSSMSGIR 130 140 150 160 170 >>NP_061967 (OMIM: 609229) diphosphoinositol polyphospha (180 aa) initn: 845 init1: 845 opt: 845 Z-score: 1114.2 bits: 212.7 E(85289): 2.5e-55 Smith-Waterman score: 845; 79.1% identity (90.5% similar) in 158 aa overlap (1-158:1-158) 10 20 30 40 50 60 pF1KB6 MMKLKSNQTRTYDGDGYKKRAACLCFRSESEEEVLLVSSSRHPDRWIVPGGGMEPEEEPS :::.: ::::::: .:.::::::::::::.:.:::::::::.::.::::::::::::::. NP_061 MMKFKPNQTRTYDREGFKKRAACLCFRSEQEDEVLLVSSSRYPDQWIVPGGGMEPEEEPG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 VAAVREVCEEAGVKGTLGRLVGIFENQERKHRTYVYVLIVTEVLEDWEDSVNIGRKREWF :::::: ::::::: ::::.::::::.:::::::::: :::.::::::::::::::::: NP_061 GAAVREVYEEAGVKGKLGRLLGIFENQDRKHRTYVYVLTVTEILEDWEDSVNIGRKREWF 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 KIEDAIKVLQYHKPVQASYFETLRQGYSANNGTPVVATTYSVSAQSSMSGIR :.:::::::: ::::.: :.: :. : : ::. .: . NP_061 KVEDAIKVLQCHKPVHAEYLEKLKLGCSPANGNSTVPSLPDNNALFVTAAQTSGLPSSVR 130 140 150 160 170 180 >>NP_950241 (OMIM: 609229) diphosphoinositol polyphospha (181 aa) initn: 836 init1: 482 opt: 833 Z-score: 1098.5 bits: 209.8 E(85289): 1.9e-54 Smith-Waterman score: 833; 78.6% identity (89.9% similar) in 159 aa overlap (1-158:1-159) 10 20 30 40 50 60 pF1KB6 MMKLKSNQTRTYDGDGYKKRAACLCFRSESEEEVLLVSSSRHPDRWIVPGGGMEPEEEPS :::.: ::::::: .:.::::::::::::.:.:::::::::.::.::::::::::::::. NP_950 MMKFKPNQTRTYDREGFKKRAACLCFRSEQEDEVLLVSSSRYPDQWIVPGGGMEPEEEPG 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 VAAVREVCEEAGVKGTLGRLVGIFE-NQERKHRTYVYVLIVTEVLEDWEDSVNIGRKREW :::::: ::::::: ::::.:::: ::.:::::::::: :::.:::::::::::::::: NP_950 GAAVREVYEEAGVKGKLGRLLGIFEQNQDRKHRTYVYVLTVTEILEDWEDSVNIGRKREW 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB6 FKIEDAIKVLQYHKPVQASYFETLRQGYSANNGTPVVATTYSVSAQSSMSGIR ::.:::::::: ::::.: :.: :. : : ::. .: . NP_950 FKVEDAIKVLQCHKPVHAEYLEKLKLGCSPANGNSTVPSLPDNNALFVTAAQTSGLPSSV 130 140 150 160 170 180 NP_950 R >>NP_060629 (OMIM: 300528) diphosphoinositol polyphospha (164 aa) initn: 821 init1: 477 opt: 818 Z-score: 1079.4 bits: 206.1 E(85289): 2.2e-53 Smith-Waterman score: 818; 76.7% identity (89.3% similar) in 159 aa overlap (2-159:1-159) 10 20 30 40 50 60 pF1KB6 MMKLKSNQTRTYDGDGYKKRAACLCFRSESEEEVLLVSSSRHPDRWIVPGGGMEPEEEPS :: : ::::::: .:.:::::::::::: :.:::::::::.:::::::::::::::::. NP_060 MKCKPNQTRTYDPEGFKKRAACLCFRSEREDEVLLVSSSRYPDRWIVPGGGMEPEEEPG 10 20 30 40 50 70 80 90 100 110 pF1KB6 VAAVREVCEEAGVKGTLGRLVGIFE-NQERKHRTYVYVLIVTEVLEDWEDSVNIGRKREW :::::: ::::::: ::::.:.:: ::.:::::::::: :::.::::::::.::::::: NP_060 GAAVREVYEEAGVKGKLGRLLGVFEQNQDRKHRTYVYVLTVTELLEDWEDSVSIGRKREW 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 FKIEDAIKVLQYHKPVQASYFETLRQGYSANNGTPVVATTYSVSAQSSMSGIR ::.:::::::: ::::.: :.: :. : : .::. .. .. NP_060 FKVEDAIKVLQCHKPVHAEYLEKLKLGGSPTNGNSMAPSSPDSDP 120 130 140 150 160 >>NP_694853 (OMIM: 300527) diphosphoinositol polyphospha (164 aa) initn: 810 init1: 476 opt: 808 Z-score: 1066.3 bits: 203.7 E(85289): 1.2e-52 Smith-Waterman score: 808; 76.1% identity (88.7% similar) in 159 aa overlap (2-159:1-159) 10 20 30 40 50 60 pF1KB6 MMKLKSNQTRTYDGDGYKKRAACLCFRSESEEEVLLVSSSRHPDRWIVPGGGMEPEEEPS :: : ::::::: .:.:::::::::::: :.:::::::::.:::::::::::::::::. NP_694 MKCKPNQTRTYDPEGFKKRAACLCFRSEREDEVLLVSSSRYPDRWIVPGGGMEPEEEPG 10 20 30 40 50 70 80 90 100 110 pF1KB6 VAAVREVCEEAGVKGTLGRLVGIFE-NQERKHRTYVYVLIVTEVLEDWEDSVNIGRKREW :::::: ::::::: ::::.:.:: ::. ::::::::: :::.::::::::.::::::: NP_694 GAAVREVYEEAGVKGKLGRLLGVFEQNQDPKHRTYVYVLTVTELLEDWEDSVSIGRKREW 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 FKIEDAIKVLQYHKPVQASYFETLRQGYSANNGTPVVATTYSVSAQSSMSGIR ::.:::::::: ::::.: :.: :. : : .::. .. .. NP_694 FKVEDAIKVLQCHKPVHAEYLEKLKLGGSPTNGNSMAPSSPDSDP 120 130 140 150 160 >>NP_001291892 (OMIM: 300527) diphosphoinositol polyphos (164 aa) initn: 810 init1: 476 opt: 808 Z-score: 1066.3 bits: 203.7 E(85289): 1.2e-52 Smith-Waterman score: 808; 76.1% identity (88.7% similar) in 159 aa overlap (2-159:1-159) 10 20 30 40 50 60 pF1KB6 MMKLKSNQTRTYDGDGYKKRAACLCFRSESEEEVLLVSSSRHPDRWIVPGGGMEPEEEPS :: : ::::::: .:.:::::::::::: :.:::::::::.:::::::::::::::::. NP_001 MKCKPNQTRTYDPEGFKKRAACLCFRSEREDEVLLVSSSRYPDRWIVPGGGMEPEEEPG 10 20 30 40 50 70 80 90 100 110 pF1KB6 VAAVREVCEEAGVKGTLGRLVGIFE-NQERKHRTYVYVLIVTEVLEDWEDSVNIGRKREW :::::: ::::::: ::::.:.:: ::. ::::::::: :::.::::::::.::::::: NP_001 GAAVREVYEEAGVKGKLGRLLGVFEQNQDPKHRTYVYVLTVTELLEDWEDSVSIGRKREW 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 FKIEDAIKVLQYHKPVQASYFETLRQGYSANNGTPVVATTYSVSAQSSMSGIR ::.:::::::: ::::.: :.: :. : : .::. .. .. NP_001 FKVEDAIKVLQCHKPVHAEYLEKLKLGGSPTNGNSMAPSSPDSDP 120 130 140 150 160 >>XP_011536097 (OMIM: 609229) PREDICTED: diphosphoinosit (128 aa) initn: 551 init1: 539 opt: 539 Z-score: 715.3 bits: 138.4 E(85289): 4.2e-33 Smith-Waterman score: 539; 77.4% identity (87.7% similar) in 106 aa overlap (53-158:1-106) 30 40 50 60 70 80 pF1KB6 CLCFRSESEEEVLLVSSSRHPDRWIVPGGGMEPEEEPSVAAVREVCEEAGVKGTLGRLVG :::::::. :::::: ::::::: ::::.: XP_011 MEPEEEPGGAAVREVYEEAGVKGKLGRLLG 10 20 30 90 100 110 120 130 140 pF1KB6 IFENQERKHRTYVYVLIVTEVLEDWEDSVNIGRKREWFKIEDAIKVLQYHKPVQASYFET :::::.:::::::::: :::.::::::::::::::::::.:::::::: ::::.: :.: XP_011 IFENQDRKHRTYVYVLTVTEILEDWEDSVNIGRKREWFKVEDAIKVLQCHKPVHAEYLEK 40 50 60 70 80 90 150 160 170 pF1KB6 LRQGYSANNGTPVVATTYSVSAQSSMSGIR :. : : ::. .: . XP_011 LKLGCSPANGNSTVPSLPDNNALFVTAAQTSGLPSSVR 100 110 120 >>NP_001287953 (OMIM: 609229) diphosphoinositol polyphos (128 aa) initn: 551 init1: 539 opt: 539 Z-score: 715.3 bits: 138.4 E(85289): 4.2e-33 Smith-Waterman score: 539; 77.4% identity (87.7% similar) in 106 aa overlap (53-158:1-106) 30 40 50 60 70 80 pF1KB6 CLCFRSESEEEVLLVSSSRHPDRWIVPGGGMEPEEEPSVAAVREVCEEAGVKGTLGRLVG :::::::. :::::: ::::::: ::::.: NP_001 MEPEEEPGGAAVREVYEEAGVKGKLGRLLG 10 20 30 90 100 110 120 130 140 pF1KB6 IFENQERKHRTYVYVLIVTEVLEDWEDSVNIGRKREWFKIEDAIKVLQYHKPVQASYFET :::::.:::::::::: :::.::::::::::::::::::.:::::::: ::::.: :.: NP_001 IFENQDRKHRTYVYVLTVTEILEDWEDSVNIGRKREWFKVEDAIKVLQCHKPVHAEYLEK 40 50 60 70 80 90 150 160 170 pF1KB6 LRQGYSANNGTPVVATTYSVSAQSSMSGIR :. : : ::. .: . NP_001 LKLGCSPANGNSTVPSLPDNNALFVTAAQTSGLPSSVR 100 110 120 >>NP_001287952 (OMIM: 609229) diphosphoinositol polyphos (128 aa) initn: 551 init1: 539 opt: 539 Z-score: 715.3 bits: 138.4 E(85289): 4.2e-33 Smith-Waterman score: 539; 77.4% identity (87.7% similar) in 106 aa overlap (53-158:1-106) 30 40 50 60 70 80 pF1KB6 CLCFRSESEEEVLLVSSSRHPDRWIVPGGGMEPEEEPSVAAVREVCEEAGVKGTLGRLVG :::::::. :::::: ::::::: ::::.: NP_001 MEPEEEPGGAAVREVYEEAGVKGKLGRLLG 10 20 30 90 100 110 120 130 140 pF1KB6 IFENQERKHRTYVYVLIVTEVLEDWEDSVNIGRKREWFKIEDAIKVLQYHKPVQASYFET :::::.:::::::::: :::.::::::::::::::::::.:::::::: ::::.: :.: NP_001 IFENQDRKHRTYVYVLTVTEILEDWEDSVNIGRKREWFKVEDAIKVLQCHKPVHAEYLEK 40 50 60 70 80 90 150 160 170 pF1KB6 LRQGYSANNGTPVVATTYSVSAQSSMSGIR :. : : ::. .: . NP_001 LKLGCSPANGNSTVPSLPDNNALFVTAAQTSGLPSSVR 100 110 120 >>XP_011536098 (OMIM: 609229) PREDICTED: diphosphoinosit (128 aa) initn: 551 init1: 539 opt: 539 Z-score: 715.3 bits: 138.4 E(85289): 4.2e-33 Smith-Waterman score: 539; 77.4% identity (87.7% similar) in 106 aa overlap (53-158:1-106) 30 40 50 60 70 80 pF1KB6 CLCFRSESEEEVLLVSSSRHPDRWIVPGGGMEPEEEPSVAAVREVCEEAGVKGTLGRLVG :::::::. :::::: ::::::: ::::.: XP_011 MEPEEEPGGAAVREVYEEAGVKGKLGRLLG 10 20 30 90 100 110 120 130 140 pF1KB6 IFENQERKHRTYVYVLIVTEVLEDWEDSVNIGRKREWFKIEDAIKVLQYHKPVQASYFET :::::.:::::::::: :::.::::::::::::::::::.:::::::: ::::.: :.: XP_011 IFENQDRKHRTYVYVLTVTEILEDWEDSVNIGRKREWFKVEDAIKVLQCHKPVHAEYLEK 40 50 60 70 80 90 150 160 170 pF1KB6 LRQGYSANNGTPVVATTYSVSAQSSMSGIR :. : : ::. .: . XP_011 LKLGCSPANGNSTVPSLPDNNALFVTAAQTSGLPSSVR 100 110 120 172 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 00:10:34 2016 done: Sat Nov 5 00:10:35 2016 Total Scan time: 4.980 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]