FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6844, 192 aa 1>>>pF1KB6844 192 - 192 aa - 192 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.3298+/-0.000319; mu= 18.7542+/- 0.020 mean_var=69.2156+/-14.043, 0's: 0 Z-trim(118.4): 404 B-trim: 1457 in 2/52 Lambda= 0.154160 statistics sampled from 30925 (31413) to 30925 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.743), E-opt: 0.2 (0.368), width: 16 Scan time: 6.050 The best scores are: opt bits E(85289) NP_005043 (OMIM: 602050) ras-related C3 botulinum ( 192) 1314 300.5 1.1e-81 NP_008839 (OMIM: 602048) ras-related C3 botulinum ( 192) 1232 282.2 3.5e-76 NP_002863 (OMIM: 602049,608203) ras-related C3 bot ( 192) 1185 271.8 4.9e-73 NP_001303236 (OMIM: 602050) ras-related C3 botulin ( 170) 1029 237.0 1.3e-62 XP_006724349 (OMIM: 602049,608203) PREDICTED: ras- ( 161) 968 223.4 1.5e-58 NP_426359 (OMIM: 116952,616737) cell division cont ( 191) 946 218.6 4.9e-57 NP_001782 (OMIM: 116952,616737) cell division cont ( 191) 929 214.8 6.7e-56 NP_001034891 (OMIM: 116952,616737) cell division c ( 191) 929 214.8 6.7e-56 XP_016873208 (OMIM: 179505) PREDICTED: rho-related ( 191) 922 213.3 2e-55 XP_005252973 (OMIM: 179505) PREDICTED: rho-related ( 191) 922 213.3 2e-55 NP_001656 (OMIM: 179505) rho-related GTP-binding p ( 191) 922 213.3 2e-55 NP_036381 (OMIM: 605857) rho-related GTP-binding p ( 205) 829 192.6 3.5e-49 NP_065714 (OMIM: 607653) rho-related GTP-binding p ( 214) 786 183.1 2.7e-46 NP_061485 (OMIM: 602048) ras-related C3 botulinum ( 211) 729 170.4 1.8e-42 NP_001300870 (OMIM: 165390) transforming protein R ( 193) 704 164.8 7.8e-41 NP_001655 (OMIM: 165390) transforming protein RhoA ( 193) 704 164.8 7.8e-41 NP_067028 (OMIM: 606366) rho-related GTP-binding p ( 258) 703 164.7 1.1e-40 NP_786886 (OMIM: 165380) rho-related GTP-binding p ( 193) 695 162.8 3.1e-40 NP_001036144 (OMIM: 165380) rho-related GTP-bindin ( 193) 695 162.8 3.1e-40 NP_001036143 (OMIM: 165380) rho-related GTP-bindin ( 193) 695 162.8 3.1e-40 NP_004031 (OMIM: 165370) rho-related GTP-binding p ( 196) 687 161.0 1.1e-39 XP_016859205 (OMIM: 605857) PREDICTED: rho-related ( 172) 675 158.3 6.3e-39 XP_011531028 (OMIM: 605857) PREDICTED: rho-related ( 192) 674 158.1 8e-39 NP_055393 (OMIM: 605781) rho-related GTP-binding p ( 210) 664 155.9 4e-38 XP_006720277 (OMIM: 607653) PREDICTED: rho-related ( 176) 641 150.7 1.2e-36 NP_001300872 (OMIM: 165390) transforming protein R ( 187) 590 139.4 3.3e-33 XP_011531030 (OMIM: 605857) PREDICTED: rho-related ( 157) 556 131.8 5.5e-31 NP_005159 (OMIM: 602924) rho-related GTP-binding p ( 244) 555 131.8 8.7e-31 NP_001241667 (OMIM: 602924) rho-related GTP-bindin ( 244) 555 131.8 8.7e-31 NP_005431 (OMIM: 601555) rho-related GTP-binding p ( 227) 553 131.3 1.1e-30 XP_011523618 (OMIM: 601555) PREDICTED: rho-related ( 234) 553 131.3 1.1e-30 NP_001265296 (OMIM: 602037) rho-related GTP-bindin ( 191) 517 123.2 2.6e-28 NP_001265288 (OMIM: 602037) rho-related GTP-bindin ( 191) 517 123.2 2.6e-28 NP_001265297 (OMIM: 602037) rho-related GTP-bindin ( 191) 517 123.2 2.6e-28 XP_011511994 (OMIM: 602037) PREDICTED: rho-related ( 191) 517 123.2 2.6e-28 NP_001265294 (OMIM: 602037) rho-related GTP-bindin ( 191) 517 123.2 2.6e-28 NP_001265298 (OMIM: 602037) rho-related GTP-bindin ( 191) 517 123.2 2.6e-28 NP_001265295 (OMIM: 602037) rho-related GTP-bindin ( 191) 517 123.2 2.6e-28 NP_001265292 (OMIM: 602037) rho-related GTP-bindin ( 191) 517 123.2 2.6e-28 NP_001265289 (OMIM: 602037) rho-related GTP-bindin ( 191) 517 123.2 2.6e-28 NP_001265291 (OMIM: 602037) rho-related GTP-bindin ( 191) 517 123.2 2.6e-28 NP_001265293 (OMIM: 602037) rho-related GTP-bindin ( 191) 517 123.2 2.6e-28 XP_016863677 (OMIM: 602037) PREDICTED: rho-related ( 191) 517 123.2 2.6e-28 NP_001265290 (OMIM: 602037) rho-related GTP-bindin ( 191) 517 123.2 2.6e-28 NP_004301 (OMIM: 602037) rho-related GTP-binding p ( 191) 517 123.2 2.6e-28 XP_016863678 (OMIM: 602037) PREDICTED: rho-related ( 191) 517 123.2 2.6e-28 NP_055285 (OMIM: 609038) rho-related GTP-binding p ( 232) 492 117.7 1.4e-26 XP_011523619 (OMIM: 601555) PREDICTED: rho-related ( 206) 464 111.4 9.6e-25 NP_001300873 (OMIM: 165390) transforming protein R ( 173) 440 106.0 3.4e-23 XP_011538730 (OMIM: 607351) PREDICTED: rho-related ( 530) 365 89.9 7.6e-18 >>NP_005043 (OMIM: 602050) ras-related C3 botulinum toxi (192 aa) initn: 1314 init1: 1314 opt: 1314 Z-score: 1587.3 bits: 300.5 E(85289): 1.1e-81 Smith-Waterman score: 1314; 100.0% identity (100.0% similar) in 192 aa overlap (1-192:1-192) 10 20 30 40 50 60 pF1KB6 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPHTPILLVGTKLDLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPHTPILLVGTKLDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 DDKDTIERLRDKKLAPITYPQGLAMAREIGSVKYLECSALTQRGLKTVFDEAIRAVLCPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 DDKDTIERLRDKKLAPITYPQGLAMAREIGSVKYLECSALTQRGLKTVFDEAIRAVLCPP 130 140 150 160 170 180 190 pF1KB6 PVKKPGKKCTVF :::::::::::: NP_005 PVKKPGKKCTVF 190 >>NP_008839 (OMIM: 602048) ras-related C3 botulinum toxi (192 aa) initn: 1268 init1: 1232 opt: 1232 Z-score: 1488.7 bits: 282.2 E(85289): 3.5e-76 Smith-Waterman score: 1232; 92.7% identity (98.4% similar) in 192 aa overlap (1-192:1-192) 10 20 30 40 50 60 pF1KB6 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPHTPILLVGTKLDLR ::::::::::::::::::::::::::::::::::::::::::::::.:::.::::::::: NP_008 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 DDKDTIERLRDKKLAPITYPQGLAMAREIGSVKYLECSALTQRGLKTVFDEAIRAVLCPP :::::::.:..:::.:::::::::::.:::.::::::::::::::::::::::::::::: NP_008 DDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPP 130 140 150 160 170 180 190 pF1KB6 PVKKPGKKCTVF :::: .:: .. NP_008 PVKKRKRKCLLL 190 >>NP_002863 (OMIM: 602049,608203) ras-related C3 botulin (192 aa) initn: 1220 init1: 1185 opt: 1185 Z-score: 1432.2 bits: 271.8 E(85289): 4.9e-73 Smith-Waterman score: 1185; 88.5% identity (96.9% similar) in 192 aa overlap (1-192:1-192) 10 20 30 40 50 60 pF1KB6 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG :::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::: NP_002 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPHTPILLVGTKLDLR :::::::::::::::::::::::::::::.:::::::.:::::::: :::.::::::::: NP_002 QEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 DDKDTIERLRDKKLAPITYPQGLAMAREIGSVKYLECSALTQRGLKTVFDEAIRAVLCPP :::::::.:..:::::::::::::.:.:: ::::::::::::::::::::::::::::: NP_002 DDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQ 130 140 150 160 170 180 190 pF1KB6 PVKKPGKKCTVF :... . :... NP_002 PTRQQKRACSLL 190 >>NP_001303236 (OMIM: 602050) ras-related C3 botulinum t (170 aa) initn: 1061 init1: 1029 opt: 1029 Z-score: 1245.4 bits: 237.0 E(85289): 1.3e-62 Smith-Waterman score: 1029; 98.7% identity (100.0% similar) in 152 aa overlap (1-152:1-152) 10 20 30 40 50 60 pF1KB6 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPHTPILLVGTKLDLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPHTPILLVGTKLDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 DDKDTIERLRDKKLAPITYPQGLAMAREIGSVKYLECSALTQRGLKTVFDEAIRAVLCPP ::::::::::::::::::::::::::::::.. NP_001 DDKDTIERLRDKKLAPITYPQGLAMAREIGGLCEIPGVLSPDPAGPEDSV 130 140 150 160 170 190 pF1KB6 PVKKPGKKCTVF >>XP_006724349 (OMIM: 602049,608203) PREDICTED: ras-rela (161 aa) initn: 968 init1: 968 opt: 968 Z-score: 1172.3 bits: 223.4 E(85289): 1.5e-58 Smith-Waterman score: 968; 93.3% identity (99.3% similar) in 149 aa overlap (1-149:1-149) 10 20 30 40 50 60 pF1KB6 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG :::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::: XP_006 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPHTPILLVGTKLDLR :::::::::::::::::::::::::::::.:::::::.:::::::: :::.::::::::: XP_006 QEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 DDKDTIERLRDKKLAPITYPQGLAMAREIGSVKYLECSALTQRGLKTVFDEAIRAVLCPP :::::::.:..:::::::::::::.:.:: XP_006 DDKDTIEKLKEKKLAPITYPQGLALAKEIEKHQNSRPPSTD 130 140 150 160 >>NP_426359 (OMIM: 116952,616737) cell division control (191 aa) initn: 994 init1: 917 opt: 946 Z-score: 1145.0 bits: 218.6 E(85289): 4.9e-57 Smith-Waterman score: 946; 70.3% identity (88.0% similar) in 192 aa overlap (1-192:1-191) 10 20 30 40 50 60 pF1KB6 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG ::.::::::::::::::::::::::: ::.::.:::::::...::. :.: .:::.:::: NP_426 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPHTPILLVGTKLDLR :::::::::::::::::::.:::.:::.:::::. :: ::. ::::.::.:::::..::: NP_426 QEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 DDKDTIERLRDKKLAPITYPQGLAMAREIGSVKYLECSALTQRGLKTVFDEAIRAVLCPP :: .:::.: .: ::: . .::.. .:::.:::::::::::.:::::: :.: :: NP_426 DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEPP 130 140 150 160 170 180 190 pF1KB6 PVKKPGKKCTVF .. : .:: .: NP_426 ETQ-PKRKCCIF 190 >>NP_001782 (OMIM: 116952,616737) cell division control (191 aa) initn: 948 init1: 920 opt: 929 Z-score: 1124.6 bits: 214.8 E(85289): 6.7e-56 Smith-Waterman score: 929; 69.3% identity (88.5% similar) in 192 aa overlap (1-192:1-191) 10 20 30 40 50 60 pF1KB6 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG ::.::::::::::::::::::::::: ::.::.:::::::...::. :.: .:::.:::: NP_001 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPHTPILLVGTKLDLR :::::::::::::::::::.:::.:::.:::::. :: ::. ::::.::.:::::..::: NP_001 QEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 DDKDTIERLRDKKLAPITYPQGLAMAREIGSVKYLECSALTQRGLKTVFDEAIRAVLCPP :: .:::.: .: ::: . .::.. .:::.:::::::.:::.:::::: :.: :: NP_001 DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPP 130 140 150 160 170 180 190 pF1KB6 PVKKPGKKCTVF :: ...:... NP_001 EPKK-SRRCVLL 190 >>NP_001034891 (OMIM: 116952,616737) cell division contr (191 aa) initn: 948 init1: 920 opt: 929 Z-score: 1124.6 bits: 214.8 E(85289): 6.7e-56 Smith-Waterman score: 929; 69.3% identity (88.5% similar) in 192 aa overlap (1-192:1-191) 10 20 30 40 50 60 pF1KB6 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG ::.::::::::::::::::::::::: ::.::.:::::::...::. :.: .:::.:::: NP_001 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPHTPILLVGTKLDLR :::::::::::::::::::.:::.:::.:::::. :: ::. ::::.::.:::::..::: NP_001 QEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 DDKDTIERLRDKKLAPITYPQGLAMAREIGSVKYLECSALTQRGLKTVFDEAIRAVLCPP :: .:::.: .: ::: . .::.. .:::.:::::::.:::.:::::: :.: :: NP_001 DDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPP 130 140 150 160 170 180 190 pF1KB6 PVKKPGKKCTVF :: ...:... NP_001 EPKK-SRRCVLL 190 >>XP_016873208 (OMIM: 179505) PREDICTED: rho-related GTP (191 aa) initn: 947 init1: 909 opt: 922 Z-score: 1116.1 bits: 213.3 E(85289): 2e-55 Smith-Waterman score: 922; 69.8% identity (85.9% similar) in 192 aa overlap (1-192:1-191) 10 20 30 40 50 60 pF1KB6 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG ::.:::::::::::::::::: ::::::: ::::::::::::. :::. :::.:::::: XP_016 MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQSAVDGRTVNLNLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPHTPILLVGTKLDLR ::.::::: ::::::.::.::::..:: :.:::: ::.::: :::: .:::::::: ::: XP_016 QEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVCHHCPDVPILLVGTKKDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 DDKDTIERLRDKKLAPITYPQGLAMAREIGSVKYLECSALTQRGLKTVFDEAIRAVLCPP . ::..::... :::: :: :.:..: .:.::::::: : :.: :: ::.:::: : XP_016 AQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLNPT 130 140 150 160 170 180 190 pF1KB6 PVKKPGKKCTVF :.:. :..: .. XP_016 PIKR-GRSCILL 190 >>XP_005252973 (OMIM: 179505) PREDICTED: rho-related GTP (191 aa) initn: 947 init1: 909 opt: 922 Z-score: 1116.1 bits: 213.3 E(85289): 2e-55 Smith-Waterman score: 922; 69.8% identity (85.9% similar) in 192 aa overlap (1-192:1-191) 10 20 30 40 50 60 pF1KB6 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAG ::.:::::::::::::::::: ::::::: ::::::::::::. :::. :::.:::::: XP_005 MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQSAVDGRTVNLNLWDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 QEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPHTPILLVGTKLDLR ::.::::: ::::::.::.::::..:: :.:::: ::.::: :::: .:::::::: ::: XP_005 QEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVCHHCPDVPILLVGTKKDLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 DDKDTIERLRDKKLAPITYPQGLAMAREIGSVKYLECSALTQRGLKTVFDEAIRAVLCPP . ::..::... :::: :: :.:..: .:.::::::: : :.: :: ::.:::: : XP_005 AQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLNPT 130 140 150 160 170 180 190 pF1KB6 PVKKPGKKCTVF :.:. :..: .. XP_005 PIKR-GRSCILL 190 192 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 14:50:37 2016 done: Fri Nov 4 14:50:39 2016 Total Scan time: 6.050 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]