FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6845, 175 aa 1>>>pF1KB6845 175 - 175 aa - 175 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.5082+/-0.000305; mu= 17.7304+/- 0.019 mean_var=72.7787+/-14.270, 0's: 0 Z-trim(118.6): 170 B-trim: 963 in 2/53 Lambda= 0.150339 statistics sampled from 31512 (31756) to 31512 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.748), E-opt: 0.2 (0.372), width: 16 Scan time: 5.570 The best scores are: opt bits E(85289) NP_620355 (OMIM: 167805) regenerating islet-derive ( 175) 1236 276.3 1.7e-74 NP_620354 (OMIM: 167805) regenerating islet-derive ( 175) 1236 276.3 1.7e-74 NP_002571 (OMIM: 167805) regenerating islet-derive ( 175) 1236 276.3 1.7e-74 NP_001008388 (OMIM: 609933) regenerating islet-der ( 175) 1094 245.5 3.2e-65 XP_005264192 (OMIM: 609933) PREDICTED: regeneratin ( 175) 1094 245.5 3.2e-65 NP_940850 (OMIM: 609933) regenerating islet-derive ( 175) 1094 245.5 3.2e-65 NP_002900 (OMIM: 167770) lithostathine-1-alpha pre ( 166) 588 135.8 3.3e-32 NP_006498 (OMIM: 167771) lithostathine-1-beta prec ( 166) 564 130.6 1.2e-30 NP_001256969 (OMIM: 609933) regenerating islet-der ( 129) 403 95.5 3.4e-20 NP_001152824 (OMIM: 609846) regenerating islet-der ( 158) 310 75.5 4.6e-14 NP_114433 (OMIM: 609846) regenerating islet-derive ( 158) 310 75.5 4.6e-14 XP_016862605 (OMIM: 187520) PREDICTED: tetranectin ( 169) 238 59.9 2.4e-09 NP_001295323 (OMIM: 187520) tetranectin isoform 2 ( 160) 201 51.8 6e-07 NP_003269 (OMIM: 187520) tetranectin isoform 1prec ( 202) 201 51.9 7e-07 XP_016862606 (OMIM: 187520) PREDICTED: tetranectin ( 209) 199 51.5 9.7e-07 NP_525126 (OMIM: 609964) C-type lectin domain fami ( 215) 179 47.2 2e-05 XP_011518934 (OMIM: 609964) PREDICTED: C-type lect ( 215) 179 47.2 2e-05 XP_016859090 (OMIM: 604939) PREDICTED: secretory p ( 795) 179 47.8 4.9e-05 XP_011523845 (OMIM: 612264) PREDICTED: C-type mann (1156) 179 48.0 6.3e-05 NP_001007268 (OMIM: 604939) secretory phospholipas (1324) 179 48.0 6.9e-05 XP_016859088 (OMIM: 604939) PREDICTED: secretory p (1383) 179 48.0 7.1e-05 NP_001182570 (OMIM: 604939) secretory phospholipas (1461) 179 48.1 7.4e-05 XP_005246449 (OMIM: 604939) PREDICTED: secretory p (1463) 179 48.1 7.4e-05 XP_016859087 (OMIM: 604939) PREDICTED: secretory p (1463) 179 48.1 7.4e-05 NP_031392 (OMIM: 604939) secretory phospholipase A (1463) 179 48.1 7.4e-05 XP_011509122 (OMIM: 604939) PREDICTED: secretory p (1463) 179 48.1 7.4e-05 NP_006030 (OMIM: 612264) C-type mannose receptor 2 (1479) 179 48.1 7.4e-05 XP_011531176 (OMIM: 604862,613393) PREDICTED: C-ty ( 328) 168 45.0 0.00014 NP_056532 (OMIM: 604862,613393) C-type lectin doma ( 328) 168 45.0 0.00014 NP_065137 (OMIM: 606064) endosialin precursor [Hom ( 757) 169 45.6 0.00021 NP_001304928 (OMIM: 613579) C-type lectin domain f ( 179) 159 42.8 0.00036 NP_001007034 (OMIM: 613579) C-type lectin domain f ( 209) 159 42.8 0.0004 XP_016882280 (OMIM: 616838) PREDICTED: C-type lect ( 243) 158 42.7 0.00051 XP_016882279 (OMIM: 616838) PREDICTED: C-type lect ( 293) 158 42.8 0.00058 XP_016882278 (OMIM: 616838) PREDICTED: C-type lect ( 310) 158 42.8 0.0006 XP_016882275 (OMIM: 616838) PREDICTED: C-type lect ( 310) 158 42.8 0.0006 XP_016882277 (OMIM: 616838) PREDICTED: C-type lect ( 310) 158 42.8 0.0006 XP_016882276 (OMIM: 616838) PREDICTED: C-type lect ( 310) 158 42.8 0.0006 XP_016882274 (OMIM: 616838) PREDICTED: C-type lect ( 310) 158 42.8 0.0006 NP_001191047 (OMIM: 616838) C-type lectin domain f ( 378) 158 42.9 0.00069 NP_006084 (OMIM: 606814) proteoglycan 3 precursor ( 225) 155 42.0 0.00076 XP_011520836 (OMIM: 173900,601313) PREDICTED: poly (4241) 168 46.2 0.00079 XP_011520834 (OMIM: 173900,601313) PREDICTED: poly (4287) 168 46.2 0.0008 NP_000287 (OMIM: 173900,601313) polycystin-1 isofo (4302) 168 46.2 0.0008 NP_001009944 (OMIM: 173900,601313) polycystin-1 is (4303) 168 46.2 0.0008 XP_011520832 (OMIM: 173900,601313) PREDICTED: poly (4311) 168 46.2 0.0008 XP_011520831 (OMIM: 173900,601313) PREDICTED: poly (4320) 168 46.2 0.0008 XP_011520830 (OMIM: 173900,601313) PREDICTED: poly (4321) 168 46.2 0.0008 NP_006335 (OMIM: 605999) C-type lectin domain fami ( 292) 154 41.9 0.0011 XP_011521915 (OMIM: 605999) PREDICTED: C-type lect ( 319) 154 41.9 0.0011 >>NP_620355 (OMIM: 167805) regenerating islet-derived pr (175 aa) initn: 1236 init1: 1236 opt: 1236 Z-score: 1458.5 bits: 276.3 E(85289): 1.7e-74 Smith-Waterman score: 1236; 100.0% identity (100.0% similar) in 175 aa overlap (1-175:1-175) 10 20 30 40 50 60 pF1KB6 MLPPMALPSVSWMLLSCLMLLSQVQGEEPQRELPSARIRCPKGSKAYGSHCYALFLSPKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 MLPPMALPSVSWMLLSCLMLLSQVQGEEPQRELPSARIRCPKGSKAYGSHCYALFLSPKS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 WTDADLACQKRPSGNLVSVLSGAEGSFVSSLVKSIGNSYSYVWIGLHDPTQGTEPNGEGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 WTDADLACQKRPSGNLVSVLSGAEGSFVSSLVKSIGNSYSYVWIGLHDPTQGTEPNGEGW 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 EWSSSDVMNYFAWERNPSTISSPGHCASLSRSTAFLRWKDYNCNVRLPYVCKFTD ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 EWSSSDVMNYFAWERNPSTISSPGHCASLSRSTAFLRWKDYNCNVRLPYVCKFTD 130 140 150 160 170 >>NP_620354 (OMIM: 167805) regenerating islet-derived pr (175 aa) initn: 1236 init1: 1236 opt: 1236 Z-score: 1458.5 bits: 276.3 E(85289): 1.7e-74 Smith-Waterman score: 1236; 100.0% identity (100.0% similar) in 175 aa overlap (1-175:1-175) 10 20 30 40 50 60 pF1KB6 MLPPMALPSVSWMLLSCLMLLSQVQGEEPQRELPSARIRCPKGSKAYGSHCYALFLSPKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 MLPPMALPSVSWMLLSCLMLLSQVQGEEPQRELPSARIRCPKGSKAYGSHCYALFLSPKS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 WTDADLACQKRPSGNLVSVLSGAEGSFVSSLVKSIGNSYSYVWIGLHDPTQGTEPNGEGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 WTDADLACQKRPSGNLVSVLSGAEGSFVSSLVKSIGNSYSYVWIGLHDPTQGTEPNGEGW 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 EWSSSDVMNYFAWERNPSTISSPGHCASLSRSTAFLRWKDYNCNVRLPYVCKFTD ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_620 EWSSSDVMNYFAWERNPSTISSPGHCASLSRSTAFLRWKDYNCNVRLPYVCKFTD 130 140 150 160 170 >>NP_002571 (OMIM: 167805) regenerating islet-derived pr (175 aa) initn: 1236 init1: 1236 opt: 1236 Z-score: 1458.5 bits: 276.3 E(85289): 1.7e-74 Smith-Waterman score: 1236; 100.0% identity (100.0% similar) in 175 aa overlap (1-175:1-175) 10 20 30 40 50 60 pF1KB6 MLPPMALPSVSWMLLSCLMLLSQVQGEEPQRELPSARIRCPKGSKAYGSHCYALFLSPKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MLPPMALPSVSWMLLSCLMLLSQVQGEEPQRELPSARIRCPKGSKAYGSHCYALFLSPKS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 WTDADLACQKRPSGNLVSVLSGAEGSFVSSLVKSIGNSYSYVWIGLHDPTQGTEPNGEGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 WTDADLACQKRPSGNLVSVLSGAEGSFVSSLVKSIGNSYSYVWIGLHDPTQGTEPNGEGW 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 EWSSSDVMNYFAWERNPSTISSPGHCASLSRSTAFLRWKDYNCNVRLPYVCKFTD ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 EWSSSDVMNYFAWERNPSTISSPGHCASLSRSTAFLRWKDYNCNVRLPYVCKFTD 130 140 150 160 170 >>NP_001008388 (OMIM: 609933) regenerating islet-derived (175 aa) initn: 1133 init1: 1094 opt: 1094 Z-score: 1292.0 bits: 245.5 E(85289): 3.2e-65 Smith-Waterman score: 1094; 85.1% identity (95.4% similar) in 175 aa overlap (1-175:1-175) 10 20 30 40 50 60 pF1KB6 MLPPMALPSVSWMLLSCLMLLSQVQGEEPQRELPSARIRCPKGSKAYGSHCYALFLSPKS ::::::::::::::::::.:: :::::: :.:::: :: :::::::::: :::::::::: NP_001 MLPPMALPSVSWMLLSCLILLCQVQGEETQKELPSPRISCPKGSKAYGSPCYALFLSPKS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 WTDADLACQKRPSGNLVSVLSGAEGSFVSSLVKSIGNSYSYVWIGLHDPTQGTEPNGEGW : ::::::::::::.:::::::::::::::::.::.:::::.::::::::::.::.:.:: NP_001 WMDADLACQKRPSGKLVSVLSGAEGSFVSSLVRSISNSYSYIWIGLHDPTQGSEPDGDGW 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 EWSSSDVMNYFAWERNPSTISSPGHCASLSRSTAFLRWKDYNCNVRLPYVCKFTD ::::.:::::::::.::::: .::::.::::::.::.::::::...::::::: : NP_001 EWSSTDVMNYFAWEKNPSTILNPGHCGSLSRSTGFLKWKDYNCDAKLPYVCKFKD 130 140 150 160 170 >>XP_005264192 (OMIM: 609933) PREDICTED: regenerating is (175 aa) initn: 1133 init1: 1094 opt: 1094 Z-score: 1292.0 bits: 245.5 E(85289): 3.2e-65 Smith-Waterman score: 1094; 85.1% identity (95.4% similar) in 175 aa overlap (1-175:1-175) 10 20 30 40 50 60 pF1KB6 MLPPMALPSVSWMLLSCLMLLSQVQGEEPQRELPSARIRCPKGSKAYGSHCYALFLSPKS ::::::::::::::::::.:: :::::: :.:::: :: :::::::::: :::::::::: XP_005 MLPPMALPSVSWMLLSCLILLCQVQGEETQKELPSPRISCPKGSKAYGSPCYALFLSPKS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 WTDADLACQKRPSGNLVSVLSGAEGSFVSSLVKSIGNSYSYVWIGLHDPTQGTEPNGEGW : ::::::::::::.:::::::::::::::::.::.:::::.::::::::::.::.:.:: XP_005 WMDADLACQKRPSGKLVSVLSGAEGSFVSSLVRSISNSYSYIWIGLHDPTQGSEPDGDGW 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 EWSSSDVMNYFAWERNPSTISSPGHCASLSRSTAFLRWKDYNCNVRLPYVCKFTD ::::.:::::::::.::::: .::::.::::::.::.::::::...::::::: : XP_005 EWSSTDVMNYFAWEKNPSTILNPGHCGSLSRSTGFLKWKDYNCDAKLPYVCKFKD 130 140 150 160 170 >>NP_940850 (OMIM: 609933) regenerating islet-derived pr (175 aa) initn: 1133 init1: 1094 opt: 1094 Z-score: 1292.0 bits: 245.5 E(85289): 3.2e-65 Smith-Waterman score: 1094; 85.1% identity (95.4% similar) in 175 aa overlap (1-175:1-175) 10 20 30 40 50 60 pF1KB6 MLPPMALPSVSWMLLSCLMLLSQVQGEEPQRELPSARIRCPKGSKAYGSHCYALFLSPKS ::::::::::::::::::.:: :::::: :.:::: :: :::::::::: :::::::::: NP_940 MLPPMALPSVSWMLLSCLILLCQVQGEETQKELPSPRISCPKGSKAYGSPCYALFLSPKS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 WTDADLACQKRPSGNLVSVLSGAEGSFVSSLVKSIGNSYSYVWIGLHDPTQGTEPNGEGW : ::::::::::::.:::::::::::::::::.::.:::::.::::::::::.::.:.:: NP_940 WMDADLACQKRPSGKLVSVLSGAEGSFVSSLVRSISNSYSYIWIGLHDPTQGSEPDGDGW 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 EWSSSDVMNYFAWERNPSTISSPGHCASLSRSTAFLRWKDYNCNVRLPYVCKFTD ::::.:::::::::.::::: .::::.::::::.::.::::::...::::::: : NP_940 EWSSTDVMNYFAWEKNPSTILNPGHCGSLSRSTGFLKWKDYNCDAKLPYVCKFKD 130 140 150 160 170 >>NP_002900 (OMIM: 167770) lithostathine-1-alpha precurs (166 aa) initn: 578 init1: 417 opt: 588 Z-score: 699.2 bits: 135.8 E(85289): 3.3e-32 Smith-Waterman score: 588; 50.0% identity (76.2% similar) in 172 aa overlap (5-175:1-166) 10 20 30 40 50 60 pF1KB6 MLPPMALPSVSWMLLSCLMLLSQVQGEEPQRELPSARIRCPKGSKAYGSHCYALFLSPKS :: : .::.::::.::: ::.: : :::.::: ::.:..:: :.:: . . .. NP_002 MAQTSSYFMLISCLMFLSQSQGQEAQTELPQARISCPEGTNAYRSYCYYFNEDRET 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 WTDADLACQKRPSGNLVSVLSGAEGSFVSSLVKSIGNSYSYVWIGLHDPTQGTEPNGEGW :.:::: ::. ::::::::. :::.::.::.: :.. :::::::: .. . : NP_002 WVDADLYCQNMNSGNLVSVLTQAEGAFVASLIKESGTDDFNVWIGLHDPKKNRR-----W 60 70 80 90 100 110 130 140 150 160 170 pF1KB6 EWSSSDVMNYFAWERN-PSTISSPGHCASLSRSTAFLRWKDYNCNVRLPYVCKFTD .:::.....: .: . ::... ::.:.::. ::.: .::: :. .. .:::: . NP_002 HWSSGSLVSYKSWGIGAPSSVN-PGYCVSLTSSTGFQKWKDVPCEDKFSFVCKFKN 120 130 140 150 160 >>NP_006498 (OMIM: 167771) lithostathine-1-beta precurso (166 aa) initn: 556 init1: 397 opt: 564 Z-score: 671.0 bits: 130.6 E(85289): 1.2e-30 Smith-Waterman score: 564; 46.2% identity (74.9% similar) in 171 aa overlap (5-175:1-166) 10 20 30 40 50 60 pF1KB6 MLPPMALPSVSWMLLSCLMLLSQVQGEEPQRELPSARIRCPKGSKAYGSHCYALFLSPKS :: . .::.: ::.:: ::.: : :::. :: ::.:..:: :.:: . .:.. NP_006 MAQTNSFFMLISSLMFLSLSQGQESQTELPNPRISCPEGTNAYRSYCYYFNEDPET 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 WTDADLACQKRPSGNLVSVLSGAEGSFVSSLVKSIGNSYSYVWIGLHDPTQGTEPNGEGW :.:::: ::. ::::::::. :::.::.::.: ... : :::::::: .. . : NP_006 WVDADLYCQNMNSGNLVSVLTQAEGAFVASLIKESSTDDSNVWIGLHDPKKNRR-----W 60 70 80 90 100 110 130 140 150 160 170 pF1KB6 EWSSSDVMNYFAWERNPSTISSPGHCASLSRSTAFLRWKDYNCNVRLPYVCKFTD .:::.....: .:. . . .. :.::::. ..: .::: .:. .. .:::: . NP_006 HWSSGSLVSYKSWDTGSPSSANAGYCASLTSCSGFKKWKDESCEKKFSFVCKFKN 120 130 140 150 160 >>NP_001256969 (OMIM: 609933) regenerating islet-derived (129 aa) initn: 808 init1: 401 opt: 403 Z-score: 483.6 bits: 95.5 E(85289): 3.4e-20 Smith-Waterman score: 708; 61.1% identity (69.1% similar) in 175 aa overlap (1-175:1-129) 10 20 30 40 50 60 pF1KB6 MLPPMALPSVSWMLLSCLMLLSQVQGEEPQRELPSARIRCPKGSKAYGSHCYALFLSPKS ::::::::::::::::::.:: :::::: :.:::: :: :::::::::: :::::::::: NP_001 MLPPMALPSVSWMLLSCLILLCQVQGEETQKELPSPRISCPKGSKAYGSPCYALFLSPKS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 WTDADLACQKRPSGNLVSVLSGAEGSFVSSLVKSIGNSYSYVWIGLHDPTQGTEPNGEGW : ::: :.::.:.:: NP_001 WMDAD----------------------------------------------GSEPDGDGW 70 130 140 150 160 170 pF1KB6 EWSSSDVMNYFAWERNPSTISSPGHCASLSRSTAFLRWKDYNCNVRLPYVCKFTD ::::.:::::::::.::::: .::::.::::::.::.::::::...::::::: : NP_001 EWSSTDVMNYFAWEKNPSTILNPGHCGSLSRSTGFLKWKDYNCDAKLPYVCKFKD 80 90 100 110 120 >>NP_001152824 (OMIM: 609846) regenerating islet-derived (158 aa) initn: 254 init1: 125 opt: 310 Z-score: 373.5 bits: 75.5 E(85289): 4.6e-14 Smith-Waterman score: 310; 32.7% identity (61.7% similar) in 162 aa overlap (13-173:10-156) 10 20 30 40 50 60 pF1KB6 MLPPMALPSVSWMLLSCLMLLSQVQGEEPQRELPSARIRCPKGSKAYGSHCYALFLSPKS .::::: . : :. .: :: : : . :.::. : . .. NP_001 MASRSMRLLLLLSCLAK-TGVLGDIIMR--PS----CAPGWFYHKSNCYGYFRKLRN 10 20 30 40 50 70 80 90 100 110 pF1KB6 WTDADLACQKRPSG-NLVSVLSGAEGSFVSSLVKSIGNSYSYVWIGLHDPTQGTEPNGEG :.::.: ::. .: .:.:.:: :.: .. ... : .::::::: . . NP_001 WSDAELECQSYGNGAHLASILSLKEASTIAEYISGYQRSQP-IWIGLHDPQKRQQ----- 60 70 80 90 100 120 130 140 150 160 170 pF1KB6 WEWSSSDVMNYFAWERNPSTISSPGHCASLSRSTAFLRWKDYNCNVRLPYVCKFTD :.: .. .. : .: . ..... ::: .: .. :: :.. .:: : ..::. NP_001 WQWIDGAMYLYRSW--SGKSMGGNKHCAEMSSNNNFLTWSSNECNKRQHFLCKYRP 110 120 130 140 150 175 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 00:28:32 2016 done: Sat Nov 5 00:28:33 2016 Total Scan time: 5.570 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]