FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6857, 179 aa 1>>>pF1KB6857 179 - 179 aa - 179 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.5196+/-0.000356; mu= -0.4778+/- 0.022 mean_var=201.0906+/-40.796, 0's: 0 Z-trim(121.1): 9 B-trim: 773 in 2/56 Lambda= 0.090444 statistics sampled from 37194 (37203) to 37194 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.763), E-opt: 0.2 (0.436), width: 16 Scan time: 6.190 The best scores are: opt bits E(85289) NP_008960 (OMIM: 600621) stathmin-2 isoform 2 [Hom ( 179) 1119 157.3 1.2e-38 XP_005251199 (OMIM: 600621) PREDICTED: stathmin-2 ( 174) 1091 153.6 1.5e-37 NP_001186143 (OMIM: 600621) stathmin-2 isoform 1 [ ( 187) 1001 141.9 5.4e-34 NP_056978 (OMIM: 608362) stathmin-3 isoform 1 [Hom ( 180) 808 116.7 2e-26 NP_001263239 (OMIM: 608362) stathmin-3 isoform 2 [ ( 169) 763 110.8 1.1e-24 NP_981944 (OMIM: 151442) stathmin isoform a [Homo ( 149) 610 90.8 1e-18 NP_981946 (OMIM: 151442) stathmin isoform a [Homo ( 149) 610 90.8 1e-18 NP_005554 (OMIM: 151442) stathmin isoform a [Homo ( 149) 610 90.8 1e-18 NP_001138926 (OMIM: 151442) stathmin isoform b [Ho ( 174) 557 84.0 1.4e-16 >>NP_008960 (OMIM: 600621) stathmin-2 isoform 2 [Homo sa (179 aa) initn: 1119 init1: 1119 opt: 1119 Z-score: 814.7 bits: 157.3 E(85289): 1.2e-38 Smith-Waterman score: 1119; 100.0% identity (100.0% similar) in 179 aa overlap (1-179:1-179) 10 20 30 40 50 60 pF1KB6 MAKTAMAYKEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 MAKTAMAYKEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 PSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREHEREVLQKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 PSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREHEREVLQKA 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 LEENNNFSKMAEEKLILKMEQIKENREANLAAIIERLQEKERHAAEVRRNKELQVELSG ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 LEENNNFSKMAEEKLILKMEQIKENREANLAAIIERLQEKERHAAEVRRNKELQVELSG 130 140 150 160 170 >>XP_005251199 (OMIM: 600621) PREDICTED: stathmin-2 isof (174 aa) initn: 1091 init1: 1091 opt: 1091 Z-score: 795.2 bits: 153.6 E(85289): 1.5e-37 Smith-Waterman score: 1091; 100.0% identity (100.0% similar) in 174 aa overlap (6-179:1-174) 10 20 30 40 50 60 pF1KB6 MAKTAMAYKEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKP ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MAYKEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKP 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 PSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREHEREVLQKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREHEREVLQKA 60 70 80 90 100 110 130 140 150 160 170 pF1KB6 LEENNNFSKMAEEKLILKMEQIKENREANLAAIIERLQEKERHAAEVRRNKELQVELSG ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LEENNNFSKMAEEKLILKMEQIKENREANLAAIIERLQEKERHAAEVRRNKELQVELSG 120 130 140 150 160 170 >>NP_001186143 (OMIM: 600621) stathmin-2 isoform 1 [Homo (187 aa) initn: 1001 init1: 1001 opt: 1001 Z-score: 731.3 bits: 141.9 E(85289): 5.4e-34 Smith-Waterman score: 1001; 100.0% identity (100.0% similar) in 160 aa overlap (1-160:1-160) 10 20 30 40 50 60 pF1KB6 MAKTAMAYKEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAKTAMAYKEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 PSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREHEREVLQKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREHEREVLQKA 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 LEENNNFSKMAEEKLILKMEQIKENREANLAAIIERLQEKERHAAEVRRNKELQVELSG :::::::::::::::::::::::::::::::::::::::: NP_001 LEENNNFSKMAEEKLILKMEQIKENREANLAAIIERLQEKLVKFISSELKESIESQFLEL 130 140 150 160 170 180 NP_001 QREGEKQ >>NP_056978 (OMIM: 608362) stathmin-3 isoform 1 [Homo sa (180 aa) initn: 510 init1: 510 opt: 808 Z-score: 595.4 bits: 116.7 E(85289): 2e-26 Smith-Waterman score: 808; 72.8% identity (86.7% similar) in 180 aa overlap (1-179:1-180) 10 20 30 40 50 60 pF1KB6 MAKTAMAYKEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKP ::.: ::::::::::.::::::::: .:. ..: : ::::::..::::::.::.::: NP_056 MASTISAYKEKMKELSVLSLICSCFYTQPHPNTVYQYGDMEVKQLDKRASGQSFEVILKS 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 PSPIS-EAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREHEREVLQK :: .: :.: . ::::: ::::.::.:::::::::.:::::::::::.::::::::.: NP_056 PSDLSPESPMLSSPPKKKDTSLEELQKRLEAAEERRKTQEAQVLKQLAERREHEREVLHK 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB6 ALEENNNFSKMAEEKLILKMEQIKENREANLAAIIERLQEKERHAAEVRRNKELQVELSG :::::::::..::::: ::: :: :::.:::. :::.::: :::::::::: . :.:: NP_056 ALEENNNFSRQAEEKLNYKMELSKEIREAHLAALRERLREKELHAAEVRRNKEQREEMSG 130 140 150 160 170 180 >>NP_001263239 (OMIM: 608362) stathmin-3 isoform 2 [Homo (169 aa) initn: 510 init1: 510 opt: 763 Z-score: 564.0 bits: 110.8 E(85289): 1.1e-24 Smith-Waterman score: 763; 72.8% identity (87.0% similar) in 169 aa overlap (12-179:1-169) 10 20 30 40 50 60 pF1KB6 MAKTAMAYKEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKP :::::.::::::::: .:. ..: : ::::::..::::::.::.::: NP_001 MKELSVLSLICSCFYTQPHPNTVYQYGDMEVKQLDKRASGQSFEVILKS 10 20 30 40 70 80 90 100 110 pF1KB6 PSPIS-EAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREHEREVLQK :: .: :.: . ::::: ::::.::.:::::::::.:::::::::::.::::::::.: NP_001 PSDLSPESPMLSSPPKKKDTSLEELQKRLEAAEERRKTQEAQVLKQLAERREHEREVLHK 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB6 ALEENNNFSKMAEEKLILKMEQIKENREANLAAIIERLQEKERHAAEVRRNKELQVELSG :::::::::..::::: ::: :: :::.:::. :::.::: :::::::::: . :.:: NP_001 ALEENNNFSRQAEEKLNYKMELSKEIREAHLAALRERLREKELHAAEVRRNKEQREEMSG 110 120 130 140 150 160 >>NP_981944 (OMIM: 151442) stathmin isoform a [Homo sapi (149 aa) initn: 610 init1: 610 opt: 610 Z-score: 456.9 bits: 90.8 E(85289): 1e-18 Smith-Waterman score: 610; 74.6% identity (88.1% similar) in 134 aa overlap (39-172:5-138) 10 20 30 40 50 60 pF1KB6 KEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKPPSPISEAP :..::...::::::::::::.: : : NP_981 MASSDIQVKELEKRASGQAFELILSPRSKESVPE 10 20 30 70 80 90 100 110 120 pF1KB6 RTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREHEREVLQKALEENNNFS :. ::::::::::::::::::::::::.::.::::::::::::.::::::.::::::: NP_981 FPLSPPKKKDLSLEEIQKKLEAAEERRKSHEAEVLKQLAEKREHEKEVLQKAIEENNNFS 40 50 60 70 80 90 130 140 150 160 170 pF1KB6 KMAEEKLILKMEQIKENREANLAAIIERLQEKERHAAEVRRNKELQVELSG ::::::: ::: ::::::..:: .:::.::..: :::.::: NP_981 KMAEEKLTHKMEANKENREAQMAAKLERLREKDKHIEEVRKNKESKDPADETEAD 100 110 120 130 140 >>NP_981946 (OMIM: 151442) stathmin isoform a [Homo sapi (149 aa) initn: 610 init1: 610 opt: 610 Z-score: 456.9 bits: 90.8 E(85289): 1e-18 Smith-Waterman score: 610; 74.6% identity (88.1% similar) in 134 aa overlap (39-172:5-138) 10 20 30 40 50 60 pF1KB6 KEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKPPSPISEAP :..::...::::::::::::.: : : NP_981 MASSDIQVKELEKRASGQAFELILSPRSKESVPE 10 20 30 70 80 90 100 110 120 pF1KB6 RTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREHEREVLQKALEENNNFS :. ::::::::::::::::::::::::.::.::::::::::::.::::::.::::::: NP_981 FPLSPPKKKDLSLEEIQKKLEAAEERRKSHEAEVLKQLAEKREHEKEVLQKAIEENNNFS 40 50 60 70 80 90 130 140 150 160 170 pF1KB6 KMAEEKLILKMEQIKENREANLAAIIERLQEKERHAAEVRRNKELQVELSG ::::::: ::: ::::::..:: .:::.::..: :::.::: NP_981 KMAEEKLTHKMEANKENREAQMAAKLERLREKDKHIEEVRKNKESKDPADETEAD 100 110 120 130 140 >>NP_005554 (OMIM: 151442) stathmin isoform a [Homo sapi (149 aa) initn: 610 init1: 610 opt: 610 Z-score: 456.9 bits: 90.8 E(85289): 1e-18 Smith-Waterman score: 610; 74.6% identity (88.1% similar) in 134 aa overlap (39-172:5-138) 10 20 30 40 50 60 pF1KB6 KEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKPPSPISEAP :..::...::::::::::::.: : : NP_005 MASSDIQVKELEKRASGQAFELILSPRSKESVPE 10 20 30 70 80 90 100 110 120 pF1KB6 RTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREHEREVLQKALEENNNFS :. ::::::::::::::::::::::::.::.::::::::::::.::::::.::::::: NP_005 FPLSPPKKKDLSLEEIQKKLEAAEERRKSHEAEVLKQLAEKREHEKEVLQKAIEENNNFS 40 50 60 70 80 90 130 140 150 160 170 pF1KB6 KMAEEKLILKMEQIKENREANLAAIIERLQEKERHAAEVRRNKELQVELSG ::::::: ::: ::::::..:: .:::.::..: :::.::: NP_005 KMAEEKLTHKMEANKENREAQMAAKLERLREKDKHIEEVRKNKESKDPADETEAD 100 110 120 130 140 >>NP_001138926 (OMIM: 151442) stathmin isoform b [Homo s (174 aa) initn: 557 init1: 557 opt: 557 Z-score: 418.6 bits: 84.0 E(85289): 1.4e-16 Smith-Waterman score: 557; 76.2% identity (88.5% similar) in 122 aa overlap (39-160:5-126) 10 20 30 40 50 60 pF1KB6 KEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKPPSPISEAP :..::...::::::::::::.: : : NP_001 MASSDIQVKELEKRASGQAFELILSPRSKESVPE 10 20 30 70 80 90 100 110 120 pF1KB6 RTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREHEREVLQKALEENNNFS :. ::::::::::::::::::::::::.::.::::::::::::.::::::.::::::: NP_001 FPLSPPKKKDLSLEEIQKKLEAAEERRKSHEAEVLKQLAEKREHEKEVLQKAIEENNNFS 40 50 60 70 80 90 130 140 150 160 170 pF1KB6 KMAEEKLILKMEQIKENREANLAAIIERLQEKERHAAEVRRNKELQVELSG ::::::: ::: ::::::..:: .:::.:: NP_001 KMAEEKLTHKMEANKENREAQMAAKLERLREKMYFWTHGPGAHPAQISAEQSCLHSVPAL 100 110 120 130 140 150 NP_001 CPALGLQSALITWSDLSHHH 160 170 179 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 18:19:15 2016 done: Sat Nov 5 18:19:16 2016 Total Scan time: 6.190 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]