FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6860, 187 aa 1>>>pF1KB6860 187 - 187 aa - 187 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.6149+/-0.000313; mu= 17.3812+/- 0.019 mean_var=65.9608+/-13.508, 0's: 0 Z-trim(117.7): 38 B-trim: 682 in 1/52 Lambda= 0.157918 statistics sampled from 29807 (29850) to 29807 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.73), E-opt: 0.2 (0.35), width: 16 Scan time: 6.010 The best scores are: opt bits E(85289) NP_005000 (OMIM: 601818) nucleoside diphosphate ki ( 187) 1278 299.1 2.6e-81 NP_001273364 (OMIM: 601818) nucleoside diphosphate ( 173) 1010 238.1 6e-63 NP_001273365 (OMIM: 601818) nucleoside diphosphate ( 117) 786 186.9 1e-47 NP_001273367 (OMIM: 601818) nucleoside diphosphate ( 117) 786 186.9 1e-47 NP_001273369 (OMIM: 601818) nucleoside diphosphate ( 117) 786 186.9 1e-47 NP_001273368 (OMIM: 601818) nucleoside diphosphate ( 117) 786 186.9 1e-47 NP_002504 (OMIM: 601817) nucleoside diphosphate ki ( 169) 652 156.5 2.1e-38 NP_000260 (OMIM: 156490,256700) nucleoside diphosp ( 152) 621 149.4 2.6e-36 NP_937818 (OMIM: 156490,256700) nucleoside diphosp ( 177) 621 149.4 2.9e-36 NP_001018147 (OMIM: 156491) nucleoside diphosphate ( 152) 609 146.6 1.7e-35 NP_001018148 (OMIM: 156491) nucleoside diphosphate ( 152) 609 146.6 1.7e-35 NP_001018149 (OMIM: 156491) nucleoside diphosphate ( 152) 609 146.6 1.7e-35 NP_002503 (OMIM: 156491) nucleoside diphosphate ki ( 152) 609 146.6 1.7e-35 NP_001273362 (OMIM: 601818) nucleoside diphosphate ( 153) 535 129.8 2.1e-30 XP_005255389 (OMIM: 601817) PREDICTED: nucleoside ( 165) 499 121.6 6.4e-28 NP_001185611 (OMIM: 156491) nucleoside diphosphate ( 82) 328 82.4 2.1e-16 XP_011520805 (OMIM: 601817) PREDICTED: nucleoside ( 170) 308 78.1 8.3e-15 NP_932076 (OMIM: 613465) nucleoside diphosphate ki ( 340) 250 65.2 1.3e-10 XP_016856588 (OMIM: 613465) PREDICTED: nucleoside ( 367) 250 65.2 1.4e-10 NP_037462 (OMIM: 613465) nucleoside diphosphate ki ( 376) 250 65.2 1.4e-10 XP_005272156 (OMIM: 603575) PREDICTED: nucleoside ( 148) 232 60.7 1.2e-09 NP_001295356 (OMIM: 608294) nucleoside diphosphate ( 186) 231 60.6 1.7e-09 NP_001295357 (OMIM: 608294) nucleoside diphosphate ( 186) 231 60.6 1.7e-09 XP_016861003 (OMIM: 608294) PREDICTED: nucleoside ( 186) 231 60.6 1.7e-09 NP_001295355 (OMIM: 608294) nucleoside diphosphate ( 186) 231 60.6 1.7e-09 XP_016861002 (OMIM: 608294) PREDICTED: nucleoside ( 190) 231 60.6 1.7e-09 NP_005784 (OMIM: 608294) nucleoside diphosphate ki ( 194) 231 60.6 1.7e-09 XP_006714779 (OMIM: 603575) PREDICTED: nucleoside ( 149) 229 60.1 2e-09 NP_003542 (OMIM: 603575) nucleoside diphosphate ki ( 212) 229 60.2 2.5e-09 XP_016865434 (OMIM: 603575) PREDICTED: nucleoside ( 278) 229 60.3 3.1e-09 XP_011520806 (OMIM: 601817) PREDICTED: nucleoside ( 136) 193 51.8 5.4e-07 NP_057700 (OMIM: 607421,610852) thioredoxin domain ( 588) 194 52.6 1.3e-06 NP_001295363 (OMIM: 608294) nucleoside diphosphate ( 141) 186 50.2 1.7e-06 XP_005245163 (OMIM: 613465) PREDICTED: nucleoside ( 252) 169 46.6 3.8e-05 XP_016856589 (OMIM: 613465) PREDICTED: nucleoside ( 252) 169 46.6 3.8e-05 XP_016861007 (OMIM: 608294) PREDICTED: nucleoside ( 111) 156 43.3 0.00016 XP_016861001 (OMIM: 608294) PREDICTED: nucleoside ( 264) 153 43.0 0.00049 XP_016861006 (OMIM: 608294) PREDICTED: nucleoside ( 114) 143 40.4 0.0013 >>NP_005000 (OMIM: 601818) nucleoside diphosphate kinase (187 aa) initn: 1278 init1: 1278 opt: 1278 Z-score: 1580.6 bits: 299.1 E(85289): 2.6e-81 Smith-Waterman score: 1278; 100.0% identity (100.0% similar) in 187 aa overlap (1-187:1-187) 10 20 30 40 50 60 pF1KB6 MGGLFWRSALRGLRCGPRAPGPSLLVRHGSGGPSWTRERTLVAVKPDGVQRRLVGDVIQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MGGLFWRSALRGLRCGPRAPGPSLLVRHGSGGPSWTRERTLVAVKPDGVQRRLVGDVIQR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 FERRGFTLVGMKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 FERRGFTLVGMKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRAS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 RAMIGHTDSAEAAPGTIRGDFSVHISRNVIHASDSVEGAQREIQLWFQSSELVSWADGGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 RAMIGHTDSAEAAPGTIRGDFSVHISRNVIHASDSVEGAQREIQLWFQSSELVSWADGGQ 130 140 150 160 170 180 pF1KB6 HSSIHPA ::::::: NP_005 HSSIHPA >>NP_001273364 (OMIM: 601818) nucleoside diphosphate kin (173 aa) initn: 998 init1: 998 opt: 1010 Z-score: 1251.1 bits: 238.1 E(85289): 6e-63 Smith-Waterman score: 1010; 91.5% identity (93.9% similar) in 165 aa overlap (1-165:1-162) 10 20 30 40 50 60 pF1KB6 MGGLFWRSALRGLRCGPRAPGPSLLVRHGSGGPSWTRERTLVAVKPDGVQRRLVGDVIQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGGLFWRSALRGLRCGPRAPGPSLLVRHGSGGPSWTRERTLVAVKPDGVQRRLVGDVIQR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 FERRGFTLVGMKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FERRGFTLVGMKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRAS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 RAMIGHTDSAEAAPGTIRGDFSVHISRNVIHASDSVEGAQREIQLWFQSSELVSWADGGQ :::::::::::::::::::::::::: : .. .::: :. NP_001 RAMIGHTDSAEAAPGTIRGDFSVHISS---HRLAPLDRGQREQQMVPGIPQGAHEA 130 140 150 160 170 pF1KB6 HSSIHPA >>NP_001273365 (OMIM: 601818) nucleoside diphosphate kin (117 aa) initn: 786 init1: 786 opt: 786 Z-score: 977.5 bits: 186.9 E(85289): 1e-47 Smith-Waterman score: 786; 100.0% identity (100.0% similar) in 117 aa overlap (71-187:1-117) 50 60 70 80 90 100 pF1KB6 LVAVKPDGVQRRLVGDVIQRFERRGFTLVGMKMLQAPESVLAEHYQDLRRKPFYPALIRY :::::::::::::::::::::::::::::: NP_001 MKMLQAPESVLAEHYQDLRRKPFYPALIRY 10 20 30 110 120 130 140 150 160 pF1KB6 MSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAAPGTIRGDFSVHISRNVIHASDSVEGAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAAPGTIRGDFSVHISRNVIHASDSVEGAQ 40 50 60 70 80 90 170 180 pF1KB6 REIQLWFQSSELVSWADGGQHSSIHPA ::::::::::::::::::::::::::: NP_001 REIQLWFQSSELVSWADGGQHSSIHPA 100 110 >>NP_001273367 (OMIM: 601818) nucleoside diphosphate kin (117 aa) initn: 786 init1: 786 opt: 786 Z-score: 977.5 bits: 186.9 E(85289): 1e-47 Smith-Waterman score: 786; 100.0% identity (100.0% similar) in 117 aa overlap (71-187:1-117) 50 60 70 80 90 100 pF1KB6 LVAVKPDGVQRRLVGDVIQRFERRGFTLVGMKMLQAPESVLAEHYQDLRRKPFYPALIRY :::::::::::::::::::::::::::::: NP_001 MKMLQAPESVLAEHYQDLRRKPFYPALIRY 10 20 30 110 120 130 140 150 160 pF1KB6 MSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAAPGTIRGDFSVHISRNVIHASDSVEGAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAAPGTIRGDFSVHISRNVIHASDSVEGAQ 40 50 60 70 80 90 170 180 pF1KB6 REIQLWFQSSELVSWADGGQHSSIHPA ::::::::::::::::::::::::::: NP_001 REIQLWFQSSELVSWADGGQHSSIHPA 100 110 >>NP_001273369 (OMIM: 601818) nucleoside diphosphate kin (117 aa) initn: 786 init1: 786 opt: 786 Z-score: 977.5 bits: 186.9 E(85289): 1e-47 Smith-Waterman score: 786; 100.0% identity (100.0% similar) in 117 aa overlap (71-187:1-117) 50 60 70 80 90 100 pF1KB6 LVAVKPDGVQRRLVGDVIQRFERRGFTLVGMKMLQAPESVLAEHYQDLRRKPFYPALIRY :::::::::::::::::::::::::::::: NP_001 MKMLQAPESVLAEHYQDLRRKPFYPALIRY 10 20 30 110 120 130 140 150 160 pF1KB6 MSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAAPGTIRGDFSVHISRNVIHASDSVEGAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAAPGTIRGDFSVHISRNVIHASDSVEGAQ 40 50 60 70 80 90 170 180 pF1KB6 REIQLWFQSSELVSWADGGQHSSIHPA ::::::::::::::::::::::::::: NP_001 REIQLWFQSSELVSWADGGQHSSIHPA 100 110 >>NP_001273368 (OMIM: 601818) nucleoside diphosphate kin (117 aa) initn: 786 init1: 786 opt: 786 Z-score: 977.5 bits: 186.9 E(85289): 1e-47 Smith-Waterman score: 786; 100.0% identity (100.0% similar) in 117 aa overlap (71-187:1-117) 50 60 70 80 90 100 pF1KB6 LVAVKPDGVQRRLVGDVIQRFERRGFTLVGMKMLQAPESVLAEHYQDLRRKPFYPALIRY :::::::::::::::::::::::::::::: NP_001 MKMLQAPESVLAEHYQDLRRKPFYPALIRY 10 20 30 110 120 130 140 150 160 pF1KB6 MSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAAPGTIRGDFSVHISRNVIHASDSVEGAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSSGPVVAMVWEGYNVVRASRAMIGHTDSAEAAPGTIRGDFSVHISRNVIHASDSVEGAQ 40 50 60 70 80 90 170 180 pF1KB6 REIQLWFQSSELVSWADGGQHSSIHPA ::::::::::::::::::::::::::: NP_001 REIQLWFQSSELVSWADGGQHSSIHPA 100 110 >>NP_002504 (OMIM: 601817) nucleoside diphosphate kinase (169 aa) initn: 683 init1: 652 opt: 652 Z-score: 810.4 bits: 156.5 E(85289): 2.1e-38 Smith-Waterman score: 652; 61.8% identity (88.9% similar) in 144 aa overlap (38-181:22-165) 10 20 30 40 50 60 pF1KB6 SALRGLRCGPRAPGPSLLVRHGSGGPSWTRERTLVAVKPDGVQRRLVGDVIQRFERRGFT :::..:::::::::::::....::::.:: NP_002 MICLVLTIFANLFPAACTGAHERTFLAVKPDGVQRRLVGEIVRRFERKGFK 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 LVGMKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHT ::..:..:: : .: ::: .::..::: :..::.:::::::::.: .:::.:::.:: : NP_002 LVALKLVQASEELLREHYAELRERPFYGRLVKYMASGPVVAMVWQGLDVVRTSRALIGAT 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 DSAEAAPGTIRGDFSVHISRNVIHASDSVEGAQREIQLWFQSSELVSWADGGQHSSIHPA . :.: :::::::: .....:.::.:::::.:.::: :::...::. : :.. : NP_002 NPADAPPGTIRGDFCIEVGKNLIHGSDSVESARREIALWFRADELLCWEDSAGHWLYE 120 130 140 150 160 >>NP_000260 (OMIM: 156490,256700) nucleoside diphosphate (152 aa) initn: 649 init1: 621 opt: 621 Z-score: 772.9 bits: 149.4 E(85289): 2.6e-36 Smith-Waterman score: 621; 58.3% identity (88.9% similar) in 144 aa overlap (38-181:5-148) 10 20 30 40 50 60 pF1KB6 SALRGLRCGPRAPGPSLLVRHGSGGPSWTRERTLVAVKPDGVQRRLVGDVIQRFERRGFT :::..:.::::::: :::..:.:::..:: NP_000 MANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFR 10 20 30 70 80 90 100 110 120 pF1KB6 LVGMKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHT :::.:..:: :..: ::: ::. .::. .:..:: ::::::::::: :::...:.:.:.: NP_000 LVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNVVKTGRVMLGET 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB6 DSAEAAPGTIRGDFSVHISRNVIHASDSVEGAQREIQLWFQSSELVSWADGGQHSSIHPA . :.. :::::::: ....::.::.:::::.:..:: :::. :::.... .:. NP_000 NPADSKPGTIRGDFCIQVGRNIIHGSDSVESAEKEIGLWFHPEELVDYTSCAQNWIYE 100 110 120 130 140 150 >>NP_937818 (OMIM: 156490,256700) nucleoside diphosphate (177 aa) initn: 636 init1: 621 opt: 621 Z-score: 772.0 bits: 149.4 E(85289): 2.9e-36 Smith-Waterman score: 621; 58.3% identity (88.9% similar) in 144 aa overlap (38-181:30-173) 10 20 30 40 50 60 pF1KB6 SALRGLRCGPRAPGPSLLVRHGSGGPSWTRERTLVAVKPDGVQRRLVGDVIQRFERRGFT :::..:.::::::: :::..:.:::..:: NP_937 MVLLSTLGIVFQGEGPPISSCDTGTMANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFR 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 LVGMKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHT :::.:..:: :..: ::: ::. .::. .:..:: ::::::::::: :::...:.:.:.: NP_937 LVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNVVKTGRVMLGET 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 DSAEAAPGTIRGDFSVHISRNVIHASDSVEGAQREIQLWFQSSELVSWADGGQHSSIHPA . :.. :::::::: ....::.::.:::::.:..:: :::. :::.... .:. NP_937 NPADSKPGTIRGDFCIQVGRNIIHGSDSVESAEKEIGLWFHPEELVDYTSCAQNWIYE 120 130 140 150 160 170 >>NP_001018147 (OMIM: 156491) nucleoside diphosphate kin (152 aa) initn: 639 init1: 609 opt: 609 Z-score: 758.1 bits: 146.6 E(85289): 1.7e-35 Smith-Waterman score: 609; 59.4% identity (89.9% similar) in 138 aa overlap (38-175:5-142) 10 20 30 40 50 60 pF1KB6 SALRGLRCGPRAPGPSLLVRHGSGGPSWTRERTLVAVKPDGVQRRLVGDVIQRFERRGFT :::..:.::::::: :::..:.:::..:: NP_001 MANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFR 10 20 30 70 80 90 100 110 120 pF1KB6 LVGMKMLQAPESVLAEHYQDLRRKPFYPALIRYMSSGPVVAMVWEGYNVVRASRAMIGHT ::.::.:.: : : .:: ::. .::.:.:..::.::::::::::: :::...:.:.:.: NP_001 LVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGET 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB6 DSAEAAPGTIRGDFSVHISRNVIHASDSVEGAQREIQLWFQSSELVSWADGGQHSSIHPA . :.. :::::::: ....::.::.::::..:..::.:::. :::.. NP_001 NPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEELVDYKSCAHDWVYE 100 110 120 130 140 150 187 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 14:10:23 2016 done: Fri Nov 4 14:10:24 2016 Total Scan time: 6.010 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]