FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6862, 195 aa 1>>>pF1KB6862 195 - 195 aa - 195 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4733+/-0.000703; mu= 13.3187+/- 0.043 mean_var=71.2795+/-14.451, 0's: 0 Z-trim(110.8): 30 B-trim: 378 in 2/51 Lambda= 0.151912 statistics sampled from 11851 (11877) to 11851 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.738), E-opt: 0.2 (0.365), width: 16 Scan time: 2.290 The best scores are: opt bits E(32554) CCDS10708.1 PYCARD gene_id:29108|Hs108|chr16 ( 195) 1264 285.3 1.6e-77 CCDS10709.1 PYCARD gene_id:29108|Hs108|chr16 ( 176) 580 135.3 2e-32 CCDS10710.1 PYDC1 gene_id:260434|Hs108|chr16 ( 89) 344 83.5 4.2e-17 CCDS58508.1 NLRP1 gene_id:22861|Hs108|chr17 (1399) 332 81.5 2.6e-15 CCDS42245.1 NLRP1 gene_id:22861|Hs108|chr17 (1429) 332 81.5 2.6e-15 CCDS42244.1 NLRP1 gene_id:22861|Hs108|chr17 (1443) 332 81.5 2.7e-15 CCDS42246.1 NLRP1 gene_id:22861|Hs108|chr17 (1473) 332 81.5 2.7e-15 >>CCDS10708.1 PYCARD gene_id:29108|Hs108|chr16 (195 aa) initn: 1264 init1: 1264 opt: 1264 Z-score: 1505.1 bits: 285.3 E(32554): 1.6e-77 Smith-Waterman score: 1264; 100.0% identity (100.0% similar) in 195 aa overlap (1-195:1-195) 10 20 30 40 50 60 pF1KB6 MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 LETYGAELTANVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 LETYGAELTANVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 ALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 ALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQA 130 140 150 160 170 180 190 pF1KB6 LRESQSYLVEDLERS ::::::::::::::: CCDS10 LRESQSYLVEDLERS 190 >>CCDS10709.1 PYCARD gene_id:29108|Hs108|chr16 (176 aa) initn: 579 init1: 579 opt: 580 Z-score: 695.5 bits: 135.3 E(32554): 2e-32 Smith-Waterman score: 1087; 90.3% identity (90.3% similar) in 195 aa overlap (1-195:1-176) 10 20 30 40 50 60 pF1KB6 MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 LETYGAELTANVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRA :::::::::::::::::::::::::::::::: ::::::::: CCDS10 LETYGAELTANVLRDMGLQEMAGQLQAATHQG-------------------LHFIDQHRA 70 80 90 100 130 140 150 160 170 180 pF1KB6 ALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 ALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQA 110 120 130 140 150 160 190 pF1KB6 LRESQSYLVEDLERS ::::::::::::::: CCDS10 LRESQSYLVEDLERS 170 >>CCDS10710.1 PYDC1 gene_id:260434|Hs108|chr16 (89 aa) initn: 344 init1: 344 opt: 344 Z-score: 420.4 bits: 83.5 E(32554): 4.2e-17 Smith-Waterman score: 344; 64.8% identity (81.8% similar) in 88 aa overlap (1-88:1-88) 10 20 30 40 50 60 pF1KB6 MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFY :: :.::: .::::: :::::::.:: .::::::. ::::::: ..: .:::::::. : CCDS10 MGTKREAILKVLENLTPEELKKFKMKLGTVPLREGFERIPRGALGQLDIVDLTDKLVASY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 LETYGAELTANVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRA : :.:::.. ::::: . : :..:: : CCDS10 YEDYAAELVVAVLRDMRMLEEAARLQRAA 70 80 >>CCDS58508.1 NLRP1 gene_id:22861|Hs108|chr17 (1399 aa) initn: 412 init1: 328 opt: 332 Z-score: 388.4 bits: 81.5 E(32554): 2.6e-15 Smith-Waterman score: 332; 44.5% identity (65.1% similar) in 146 aa overlap (54-192:1243-1385) 30 40 50 60 70 80 pF1KB6 KLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVS-FYLETYGAELTANVL--RDMGLQE :.: : ::. :. . .: .: : CCDS58 PEEVTFHLYLIPSDCSIRKELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVW 1220 1230 1240 1250 1260 1270 90 100 110 120 130 pF1KB6 MA----GQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRAALIARVTNVEWLLDAL : :.:. :: . :: : .: : :::.::.: ::::::.:: .:: : CCDS58 EALVKPGDLMPAT---TLIPPARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKL 1280 1290 1300 1310 1320 140 150 160 170 180 190 pF1KB6 YGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQALRESQSYLVEDLERS .:.::..:::. : :: : ::.::::::.. .:. ::: : :::.:.. .:. .: CCDS58 HGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKG 1330 1340 1350 1360 1370 1380 CCDS58 SKKGLLPLSS 1390 >>CCDS42245.1 NLRP1 gene_id:22861|Hs108|chr17 (1429 aa) initn: 412 init1: 328 opt: 332 Z-score: 388.2 bits: 81.5 E(32554): 2.6e-15 Smith-Waterman score: 332; 44.5% identity (65.1% similar) in 146 aa overlap (54-192:1273-1415) 30 40 50 60 70 80 pF1KB6 KLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVS-FYLETYGAELTANVL--RDMGLQE :.: : ::. :. . .: .: : CCDS42 PEEVTFHLYLIPSDCSIRKELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVW 1250 1260 1270 1280 1290 1300 90 100 110 120 130 pF1KB6 MA----GQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRAALIARVTNVEWLLDAL : :.:. :: . :: : .: : :::.::.: ::::::.:: .:: : CCDS42 EALVKPGDLMPAT---TLIPPARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKL 1310 1320 1330 1340 1350 140 150 160 170 180 190 pF1KB6 YGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQALRESQSYLVEDLERS .:.::..:::. : :: : ::.::::::.. .:. ::: : :::.:.. .:. .: CCDS42 HGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKG 1360 1370 1380 1390 1400 1410 CCDS42 SKKGLLPLSS 1420 >>CCDS42244.1 NLRP1 gene_id:22861|Hs108|chr17 (1443 aa) initn: 412 init1: 328 opt: 332 Z-score: 388.2 bits: 81.5 E(32554): 2.7e-15 Smith-Waterman score: 332; 44.5% identity (65.1% similar) in 146 aa overlap (54-192:1287-1429) 30 40 50 60 70 80 pF1KB6 KLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVS-FYLETYGAELTANVL--RDMGLQE :.: : ::. :. . .: .: : CCDS42 GCRYTVSGSGSGMLEILPKELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVW 1260 1270 1280 1290 1300 1310 90 100 110 120 130 pF1KB6 MA----GQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRAALIARVTNVEWLLDAL : :.:. :: . :: : .: : :::.::.: ::::::.:: .:: : CCDS42 EALVKPGDLMPAT---TLIPPARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKL 1320 1330 1340 1350 1360 1370 140 150 160 170 180 190 pF1KB6 YGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQALRESQSYLVEDLERS .:.::..:::. : :: : ::.::::::.. .:. ::: : :::.:.. .:. .: CCDS42 HGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKG 1380 1390 1400 1410 1420 1430 CCDS42 SKKGLLPLSS 1440 >>CCDS42246.1 NLRP1 gene_id:22861|Hs108|chr17 (1473 aa) initn: 412 init1: 328 opt: 332 Z-score: 388.0 bits: 81.5 E(32554): 2.7e-15 Smith-Waterman score: 332; 44.5% identity (65.1% similar) in 146 aa overlap (54-192:1317-1459) 30 40 50 60 70 80 pF1KB6 KLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVS-FYLETYGAELTANVL--RDMGLQE :.: : ::. :. . .: .: : CCDS42 GCRYTVSGSGSGMLEILPKELELCYRSPGEDQLFSEFYVGHLGSGIRLQVKDKKDETLVW 1290 1300 1310 1320 1330 1340 90 100 110 120 130 pF1KB6 MA----GQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRAALIARVTNVEWLLDAL : :.:. :: . :: : .: : :::.::.: ::::::.:: .:: : CCDS42 EALVKPGDLMPAT---TLIPPARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKL 1350 1360 1370 1380 1390 1400 140 150 160 170 180 190 pF1KB6 YGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQALRESQSYLVEDLERS .:.::..:::. : :: : ::.::::::.. .:. ::: : :::.:.. .:. .: CCDS42 HGQVLSQEQYERVLAENTRPSQMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMELWEKG 1410 1420 1430 1440 1450 1460 CCDS42 SKKGLLPLSS 1470 195 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 00:06:26 2016 done: Sat Nov 5 00:06:27 2016 Total Scan time: 2.290 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]