FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6863, 179 aa 1>>>pF1KB6863 179 - 179 aa - 179 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8229+/-0.000509; mu= 15.8070+/- 0.032 mean_var=88.7192+/-19.624, 0's: 0 Z-trim(110.1): 217 B-trim: 1120 in 2/50 Lambda= 0.136165 statistics sampled from 18058 (18384) to 18058 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.586), E-opt: 0.2 (0.216), width: 16 Scan time: 4.060 The best scores are: opt bits E(85289) NP_036229 (OMIM: 608960) ADP-ribosylation factor-l ( 179) 1187 243.2 1.7e-64 NP_848930 (OMIM: 608909) ADP-ribosylation factor-l ( 179) 1010 208.4 5e-54 NP_001032251 (OMIM: 608960) ADP-ribosylation facto ( 142) 941 194.7 5.2e-50 NP_817114 (OMIM: 608960) ADP-ribosylation factor-l ( 142) 941 194.7 5.2e-50 XP_005252458 (OMIM: 608909) PREDICTED: ADP-ribosyl ( 142) 816 170.2 1.3e-42 NP_001019399 (OMIM: 103180) ADP-ribosylation facto ( 181) 607 129.2 3.4e-30 NP_001649 (OMIM: 103180) ADP-ribosylation factor 1 ( 181) 607 129.2 3.4e-30 NP_001019397 (OMIM: 103180) ADP-ribosylation facto ( 181) 607 129.2 3.4e-30 NP_001019398 (OMIM: 103180) ADP-ribosylation facto ( 181) 607 129.2 3.4e-30 NP_001650 (OMIM: 103190) ADP-ribosylation factor 3 ( 181) 598 127.5 1.2e-29 XP_005268913 (OMIM: 103190) PREDICTED: ADP-ribosyl ( 181) 598 127.5 1.2e-29 NP_001168 (OMIM: 603425) ADP-ribosylation factor-l ( 181) 582 124.3 1e-28 NP_001651 (OMIM: 601177) ADP-ribosylation factor 4 ( 180) 569 121.8 6e-28 NP_001653 (OMIM: 103188) ADP-ribosylation factor 5 ( 180) 560 120.0 2.1e-27 NP_001654 (OMIM: 600464) ADP-ribosylation factor 6 ( 175) 550 118.0 7.9e-27 XP_005248554 (OMIM: 601747) PREDICTED: E3 ubiquiti ( 398) 503 109.2 8.1e-24 NP_001647 (OMIM: 601747) E3 ubiquitin-protein liga ( 574) 503 109.4 1e-23 XP_005252457 (OMIM: 608909) PREDICTED: ADP-ribosyl ( 151) 495 107.2 1.3e-23 NP_004302 (OMIM: 604695) ADP-ribosylation factor-l ( 182) 486 105.5 4.9e-23 XP_016871749 (OMIM: 604695) PREDICTED: ADP-ribosyl ( 182) 486 105.5 4.9e-23 NP_001658 (OMIM: 601175) ADP-ribosylation factor-l ( 184) 484 105.1 6.5e-23 NP_079323 (OMIM: 614439) ADP-ribosylation factor-l ( 192) 454 99.2 4e-21 XP_016856722 (OMIM: 103180) PREDICTED: ADP-ribosyl ( 212) 449 98.3 8.4e-21 XP_016864933 (OMIM: 601747) PREDICTED: E3 ubiquiti ( 569) 450 99.0 1.4e-20 NP_150230 (OMIM: 601747) E3 ubiquitin-protein liga ( 569) 450 99.0 1.4e-20 XP_006719454 (OMIM: 103190) PREDICTED: ADP-ribosyl ( 137) 436 95.5 3.7e-20 NP_001287997 (OMIM: 603425) ADP-ribosylation facto ( 135) 434 95.1 4.8e-20 XP_005266310 (OMIM: 609351) PREDICTED: ADP-ribosyl ( 196) 428 94.1 1.4e-19 NP_612459 (OMIM: 609351) ADP-ribosylation factor-l ( 196) 428 94.1 1.4e-19 NP_997625 (OMIM: 604786) ADP-ribosylation factor-l ( 200) 426 93.7 1.9e-19 NP_005729 (OMIM: 604786) ADP-ribosylation factor-l ( 200) 426 93.7 1.9e-19 NP_001032241 (OMIM: 604786) ADP-ribosylation facto ( 200) 426 93.7 1.9e-19 NP_001182325 (OMIM: 604786) ADP-ribosylation facto ( 200) 426 93.7 1.9e-19 NP_001265222 (OMIM: 209900,268000,600151,608845,61 ( 186) 423 93.1 2.7e-19 XP_016862800 (OMIM: 209900,268000,600151,608845,61 ( 186) 423 93.1 2.7e-19 NP_816931 (OMIM: 209900,268000,600151,608845,61357 ( 186) 423 93.1 2.7e-19 NP_115522 (OMIM: 209900,268000,600151,608845,61357 ( 186) 423 93.1 2.7e-19 NP_001310442 (OMIM: 209900,268000,600151,608845,61 ( 193) 420 92.5 4.1e-19 NP_150231 (OMIM: 601747) E3 ubiquitin-protein liga ( 546) 423 93.6 5.4e-19 XP_011526784 (OMIM: 604699) PREDICTED: ADP-ribosyl ( 201) 417 92.0 6.3e-19 NP_003215 (OMIM: 604699) ADP-ribosylation factor-r ( 201) 417 92.0 6.3e-19 XP_016883065 (OMIM: 604699) PREDICTED: ADP-ribosyl ( 201) 417 92.0 6.3e-19 NP_001254476 (OMIM: 604699) ADP-ribosylation facto ( 201) 417 92.0 6.3e-19 XP_011526785 (OMIM: 604699) PREDICTED: ADP-ribosyl ( 201) 417 92.0 6.3e-19 NP_001254477 (OMIM: 604699) ADP-ribosylation facto ( 201) 417 92.0 6.3e-19 NP_005728 (OMIM: 604787) ADP-ribosylation factor-l ( 192) 413 91.2 1.1e-18 NP_001269360 (OMIM: 604787) ADP-ribosylation facto ( 201) 413 91.2 1.1e-18 NP_001254478 (OMIM: 604699) ADP-ribosylation facto ( 173) 370 82.7 3.5e-16 NP_001128230 (OMIM: 604699) ADP-ribosylation facto ( 173) 370 82.7 3.5e-16 XP_011523084 (OMIM: 600732) PREDICTED: ADP-ribosyl ( 201) 370 82.7 3.8e-16 >>NP_036229 (OMIM: 608960) ADP-ribosylation factor-like (179 aa) initn: 1187 init1: 1187 opt: 1187 Z-score: 1278.8 bits: 243.2 E(85289): 1.7e-64 Smith-Waterman score: 1187; 100.0% identity (100.0% similar) in 179 aa overlap (1-179:1-179) 10 20 30 40 50 60 pF1KB6 MGILFTRIWRLFNHQEHKVIIVGLDNAGKTTILYQFSMNEVVHTSPTIGSNVEEIVINNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 MGILFTRIWRLFNHQEHKVIIVGLDNAGKTTILYQFSMNEVVHTSPTIGSNVEEIVINNT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 RFLMWDIGGQESLRSSWNTYYTNTEFVIVVVDSTDRERISVTREELYKMLAHEDLRKAGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 RFLMWDIGGQESLRSSWNTYYTNTEFVIVVVDSTDRERISVTREELYKMLAHEDLRKAGL 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 LIFANKQDVKECMTVAEISQFLKLTSIKDHQWHIQACCALTGEGLCQGLEWMMSRLKIR ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 LIFANKQDVKECMTVAEISQFLKLTSIKDHQWHIQACCALTGEGLCQGLEWMMSRLKIR 130 140 150 160 170 >>NP_848930 (OMIM: 608909) ADP-ribosylation factor-like (179 aa) initn: 1010 init1: 1010 opt: 1010 Z-score: 1090.9 bits: 208.4 E(85289): 5e-54 Smith-Waterman score: 1010; 79.9% identity (95.0% similar) in 179 aa overlap (1-179:1-179) 10 20 30 40 50 60 pF1KB6 MGILFTRIWRLFNHQEHKVIIVGLDNAGKTTILYQFSMNEVVHTSPTIGSNVEEIVINNT ::..:...: :: .:::::::::::::::::::::: :::::::::::::::::::..:: NP_848 MGLIFAKLWSLFCNQEHKVIIVGLDNAGKTTILYQFLMNEVVHTSPTIGSNVEEIVVKNT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 RFLMWDIGGQESLRSSWNTYYTNTEFVIVVVDSTDRERISVTREELYKMLAHEDLRKAGL .::::::::::::::::::::.::::.:.:::: ::::...:.::::.::::::::::.. NP_848 HFLMWDIGGQESLRSSWNTYYSNTEFIILVVDSIDRERLAITKEELYRMLAHEDLRKAAV 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 LIFANKQDVKECMTVAEISQFLKLTSIKDHQWHIQACCALTGEGLCQGLEWMMSRLKIR ::::::::.: :::.::::..: :.::::: ::::.:::::::::::::::: ::. .: NP_848 LIFANKQDMKGCMTAAEISKYLTLSSIKDHPWHIQSCCALTGEGLCQGLEWMTSRIGVR 130 140 150 160 170 >>NP_001032251 (OMIM: 608960) ADP-ribosylation factor-li (142 aa) initn: 941 init1: 941 opt: 941 Z-score: 1018.8 bits: 194.7 E(85289): 5.2e-50 Smith-Waterman score: 941; 100.0% identity (100.0% similar) in 142 aa overlap (38-179:1-142) 10 20 30 40 50 60 pF1KB6 IWRLFNHQEHKVIIVGLDNAGKTTILYQFSMNEVVHTSPTIGSNVEEIVINNTRFLMWDI :::::::::::::::::::::::::::::: NP_001 MNEVVHTSPTIGSNVEEIVINNTRFLMWDI 10 20 30 70 80 90 100 110 120 pF1KB6 GGQESLRSSWNTYYTNTEFVIVVVDSTDRERISVTREELYKMLAHEDLRKAGLLIFANKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGQESLRSSWNTYYTNTEFVIVVVDSTDRERISVTREELYKMLAHEDLRKAGLLIFANKQ 40 50 60 70 80 90 130 140 150 160 170 pF1KB6 DVKECMTVAEISQFLKLTSIKDHQWHIQACCALTGEGLCQGLEWMMSRLKIR :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DVKECMTVAEISQFLKLTSIKDHQWHIQACCALTGEGLCQGLEWMMSRLKIR 100 110 120 130 140 >>NP_817114 (OMIM: 608960) ADP-ribosylation factor-like (142 aa) initn: 941 init1: 941 opt: 941 Z-score: 1018.8 bits: 194.7 E(85289): 5.2e-50 Smith-Waterman score: 941; 100.0% identity (100.0% similar) in 142 aa overlap (38-179:1-142) 10 20 30 40 50 60 pF1KB6 IWRLFNHQEHKVIIVGLDNAGKTTILYQFSMNEVVHTSPTIGSNVEEIVINNTRFLMWDI :::::::::::::::::::::::::::::: NP_817 MNEVVHTSPTIGSNVEEIVINNTRFLMWDI 10 20 30 70 80 90 100 110 120 pF1KB6 GGQESLRSSWNTYYTNTEFVIVVVDSTDRERISVTREELYKMLAHEDLRKAGLLIFANKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_817 GGQESLRSSWNTYYTNTEFVIVVVDSTDRERISVTREELYKMLAHEDLRKAGLLIFANKQ 40 50 60 70 80 90 130 140 150 160 170 pF1KB6 DVKECMTVAEISQFLKLTSIKDHQWHIQACCALTGEGLCQGLEWMMSRLKIR :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_817 DVKECMTVAEISQFLKLTSIKDHQWHIQACCALTGEGLCQGLEWMMSRLKIR 100 110 120 130 140 >>XP_005252458 (OMIM: 608909) PREDICTED: ADP-ribosylatio (142 aa) initn: 816 init1: 816 opt: 816 Z-score: 886.1 bits: 170.2 E(85289): 1.3e-42 Smith-Waterman score: 816; 81.0% identity (95.8% similar) in 142 aa overlap (38-179:1-142) 10 20 30 40 50 60 pF1KB6 IWRLFNHQEHKVIIVGLDNAGKTTILYQFSMNEVVHTSPTIGSNVEEIVINNTRFLMWDI :::::::::::::::::::..::.:::::: XP_005 MNEVVHTSPTIGSNVEEIVVKNTHFLMWDI 10 20 30 70 80 90 100 110 120 pF1KB6 GGQESLRSSWNTYYTNTEFVIVVVDSTDRERISVTREELYKMLAHEDLRKAGLLIFANKQ ::::::::::::::.::::.:.:::: ::::...:.::::.::::::::::..::::::: XP_005 GGQESLRSSWNTYYSNTEFIILVVDSIDRERLAITKEELYRMLAHEDLRKAAVLIFANKQ 40 50 60 70 80 90 130 140 150 160 170 pF1KB6 DVKECMTVAEISQFLKLTSIKDHQWHIQACCALTGEGLCQGLEWMMSRLKIR :.: :::.::::..: :.::::: ::::.:::::::::::::::: ::. .: XP_005 DMKGCMTAAEISKYLTLSSIKDHPWHIQSCCALTGEGLCQGLEWMTSRIGVR 100 110 120 130 140 >>NP_001019399 (OMIM: 103180) ADP-ribosylation factor 1 (181 aa) initn: 592 init1: 592 opt: 607 Z-score: 663.0 bits: 129.2 E(85289): 3.4e-30 Smith-Waterman score: 607; 48.9% identity (80.9% similar) in 178 aa overlap (1-177:1-178) 10 20 30 40 50 pF1KB6 MGILFTRIWR-LFNHQEHKVIIVGLDNAGKTTILYQFSMNEVVHTSPTIGSNVEEIVINN :: .:. ... ::...: ....:::: ::::::::.....:.: : :::: ::: . .: NP_001 MGNIFANLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 TRFLMWDIGGQESLRSSWNTYYTNTEFVIVVVDSTDRERISVTREELYKMLAHEDLRKAG : .::.:::...: : :. ::. .: ::::.::::.. .::::..:::...:: : NP_001 ISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB6 LLIFANKQDVKECMTVAEISQFLKLTSIKDHQWHIQACCALTGEGLCQGLEWMMSRLKIR ::.::::::. . :..:::.. : : :.. ..:.::: :: .:.:: .::.:. ..:. NP_001 LLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLSNQLRNQ 130 140 150 160 170 180 NP_001 K >>NP_001649 (OMIM: 103180) ADP-ribosylation factor 1 [Ho (181 aa) initn: 592 init1: 592 opt: 607 Z-score: 663.0 bits: 129.2 E(85289): 3.4e-30 Smith-Waterman score: 607; 48.9% identity (80.9% similar) in 178 aa overlap (1-177:1-178) 10 20 30 40 50 pF1KB6 MGILFTRIWR-LFNHQEHKVIIVGLDNAGKTTILYQFSMNEVVHTSPTIGSNVEEIVINN :: .:. ... ::...: ....:::: ::::::::.....:.: : :::: ::: . .: NP_001 MGNIFANLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 TRFLMWDIGGQESLRSSWNTYYTNTEFVIVVVDSTDRERISVTREELYKMLAHEDLRKAG : .::.:::...: : :. ::. .: ::::.::::.. .::::..:::...:: : NP_001 ISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB6 LLIFANKQDVKECMTVAEISQFLKLTSIKDHQWHIQACCALTGEGLCQGLEWMMSRLKIR ::.::::::. . :..:::.. : : :.. ..:.::: :: .:.:: .::.:. ..:. NP_001 LLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLSNQLRNQ 130 140 150 160 170 180 NP_001 K >>NP_001019397 (OMIM: 103180) ADP-ribosylation factor 1 (181 aa) initn: 592 init1: 592 opt: 607 Z-score: 663.0 bits: 129.2 E(85289): 3.4e-30 Smith-Waterman score: 607; 48.9% identity (80.9% similar) in 178 aa overlap (1-177:1-178) 10 20 30 40 50 pF1KB6 MGILFTRIWR-LFNHQEHKVIIVGLDNAGKTTILYQFSMNEVVHTSPTIGSNVEEIVINN :: .:. ... ::...: ....:::: ::::::::.....:.: : :::: ::: . .: NP_001 MGNIFANLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 TRFLMWDIGGQESLRSSWNTYYTNTEFVIVVVDSTDRERISVTREELYKMLAHEDLRKAG : .::.:::...: : :. ::. .: ::::.::::.. .::::..:::...:: : NP_001 ISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB6 LLIFANKQDVKECMTVAEISQFLKLTSIKDHQWHIQACCALTGEGLCQGLEWMMSRLKIR ::.::::::. . :..:::.. : : :.. ..:.::: :: .:.:: .::.:. ..:. NP_001 LLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLSNQLRNQ 130 140 150 160 170 180 NP_001 K >>NP_001019398 (OMIM: 103180) ADP-ribosylation factor 1 (181 aa) initn: 592 init1: 592 opt: 607 Z-score: 663.0 bits: 129.2 E(85289): 3.4e-30 Smith-Waterman score: 607; 48.9% identity (80.9% similar) in 178 aa overlap (1-177:1-178) 10 20 30 40 50 pF1KB6 MGILFTRIWR-LFNHQEHKVIIVGLDNAGKTTILYQFSMNEVVHTSPTIGSNVEEIVINN :: .:. ... ::...: ....:::: ::::::::.....:.: : :::: ::: . .: NP_001 MGNIFANLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 TRFLMWDIGGQESLRSSWNTYYTNTEFVIVVVDSTDRERISVTREELYKMLAHEDLRKAG : .::.:::...: : :. ::. .: ::::.::::.. .::::..:::...:: : NP_001 ISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB6 LLIFANKQDVKECMTVAEISQFLKLTSIKDHQWHIQACCALTGEGLCQGLEWMMSRLKIR ::.::::::. . :..:::.. : : :.. ..:.::: :: .:.:: .::.:. ..:. NP_001 LLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLSNQLRNQ 130 140 150 160 170 180 NP_001 K >>NP_001650 (OMIM: 103190) ADP-ribosylation factor 3 [Ho (181 aa) initn: 588 init1: 588 opt: 598 Z-score: 653.4 bits: 127.5 E(85289): 1.2e-29 Smith-Waterman score: 598; 48.9% identity (79.8% similar) in 178 aa overlap (1-177:1-178) 10 20 30 40 50 pF1KB6 MGILFTRIWR-LFNHQEHKVIIVGLDNAGKTTILYQFSMNEVVHTSPTIGSNVEEIVINN :: .: . . :....: ....:::: ::::::::.....:.: : :::: ::: . .: NP_001 MGNIFGNLLKSLIGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 TRFLMWDIGGQESLRSSWNTYYTNTEFVIVVVDSTDRERISVTREELYKMLAHEDLRKAG : .::.:::...: : :. ::. .: ::::.::::.. .::::..:::...:: : NP_001 ISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB6 LLIFANKQDVKECMTVAEISQFLKLTSIKDHQWHIQACCALTGEGLCQGLEWMMSRLKIR ::.::::::. . :..:::.. : : :.. ..:.::: :: .:.:: .::.:. ..:: NP_001 LLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLANQLKNK 130 140 150 160 170 180 NP_001 K 179 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 08:10:18 2016 done: Sat Nov 5 08:10:19 2016 Total Scan time: 4.060 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]