FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6864, 195 aa 1>>>pF1KB6864 195 - 195 aa - 195 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9552+/-0.00033; mu= 14.5792+/- 0.021 mean_var=55.9627+/-11.030, 0's: 0 Z-trim(113.4): 19 B-trim: 0 in 0/55 Lambda= 0.171445 statistics sampled from 22734 (22750) to 22734 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.66), E-opt: 0.2 (0.267), width: 16 Scan time: 3.780 The best scores are: opt bits E(85289) NP_057130 (OMIM: 606493) exosome complex component ( 195) 1284 325.5 3.4e-89 XP_011538149 (OMIM: 606493) PREDICTED: exosome com ( 160) 943 241.1 7.1e-64 NP_001305291 (OMIM: 606493) exosome complex compon ( 170) 782 201.3 7.3e-52 NP_001305292 (OMIM: 606493) exosome complex compon ( 152) 764 196.8 1.4e-50 NP_001305293 (OMIM: 606493) exosome complex compon ( 129) 536 140.4 1.2e-33 XP_016871793 (OMIM: 606493) PREDICTED: exosome com ( 126) 527 138.1 5.5e-33 NP_001305295 (OMIM: 606493) exosome complex compon ( 109) 525 137.6 6.8e-33 NP_001305294 (OMIM: 606493) exosome complex compon ( 109) 525 137.6 6.8e-33 >>NP_057130 (OMIM: 606493) exosome complex component CSL (195 aa) initn: 1284 init1: 1284 opt: 1284 Z-score: 1722.3 bits: 325.5 E(85289): 3.4e-89 Smith-Waterman score: 1284; 100.0% identity (100.0% similar) in 195 aa overlap (1-195:1-195) 10 20 30 40 50 60 pF1KB6 MAPPVRYCIPGERLCNLEEGSPGSGTYTRHGYIFSSLAGCLMKSSENGALPVVSVVRETE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MAPPVRYCIPGERLCNLEEGSPGSGTYTRHGYIFSSLAGCLMKSSENGALPVVSVVRETE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 SQLLPDVGAIVTCKVSSINSRFAKVHILYVGSMPLKNSFRGTIRKEDVRATEKDKVEIYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 SQLLPDVGAIVTCKVSSINSRFAKVHILYVGSMPLKNSFRGTIRKEDVRATEKDKVEIYK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 SFRPGDIVLAKVISLGDAQSNYLLTTAENELGVVVAHSESGIQMVPISWCEMQCPKTHTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 SFRPGDIVLAKVISLGDAQSNYLLTTAENELGVVVAHSESGIQMVPISWCEMQCPKTHTK 130 140 150 160 170 180 190 pF1KB6 EFRKVARVQPEFLQT ::::::::::::::: NP_057 EFRKVARVQPEFLQT 190 >>XP_011538149 (OMIM: 606493) PREDICTED: exosome complex (160 aa) initn: 943 init1: 943 opt: 943 Z-score: 1267.8 bits: 241.1 E(85289): 7.1e-64 Smith-Waterman score: 943; 100.0% identity (100.0% similar) in 147 aa overlap (49-195:14-160) 20 30 40 50 60 70 pF1KB6 EGSPGSGTYTRHGYIFSSLAGCLMKSSENGALPVVSVVRETESQLLPDVGAIVTCKVSSI :::::::::::::::::::::::::::::: XP_011 MRTQYPIPAQLSPALPVVSVVRETESQLLPDVGAIVTCKVSSI 10 20 30 40 80 90 100 110 120 130 pF1KB6 NSRFAKVHILYVGSMPLKNSFRGTIRKEDVRATEKDKVEIYKSFRPGDIVLAKVISLGDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NSRFAKVHILYVGSMPLKNSFRGTIRKEDVRATEKDKVEIYKSFRPGDIVLAKVISLGDA 50 60 70 80 90 100 140 150 160 170 180 190 pF1KB6 QSNYLLTTAENELGVVVAHSESGIQMVPISWCEMQCPKTHTKEFRKVARVQPEFLQT ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QSNYLLTTAENELGVVVAHSESGIQMVPISWCEMQCPKTHTKEFRKVARVQPEFLQT 110 120 130 140 150 160 >>NP_001305291 (OMIM: 606493) exosome complex component (170 aa) initn: 782 init1: 782 opt: 782 Z-score: 1052.1 bits: 201.3 E(85289): 7.3e-52 Smith-Waterman score: 1068; 87.2% identity (87.2% similar) in 195 aa overlap (1-195:1-170) 10 20 30 40 50 60 pF1KB6 MAPPVRYCIPGERLCNLEEGSPGSGTYTRHGYIFSSLAGCLMKSSENGALPVVSVVRETE ::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAPPVRYCIPGERLCNLEEGSPGSGTYTRHGYIFSSLAGCLMKSSENGA----------- 10 20 30 40 70 80 90 100 110 120 pF1KB6 SQLLPDVGAIVTCKVSSINSRFAKVHILYVGSMPLKNSFRGTIRKEDVRATEKDKVEIYK :::::::::::::::::::::::::::::::::::::::::::::: NP_001 --------------VSSINSRFAKVHILYVGSMPLKNSFRGTIRKEDVRATEKDKVEIYK 50 60 70 80 90 130 140 150 160 170 180 pF1KB6 SFRPGDIVLAKVISLGDAQSNYLLTTAENELGVVVAHSESGIQMVPISWCEMQCPKTHTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SFRPGDIVLAKVISLGDAQSNYLLTTAENELGVVVAHSESGIQMVPISWCEMQCPKTHTK 100 110 120 130 140 150 190 pF1KB6 EFRKVARVQPEFLQT ::::::::::::::: NP_001 EFRKVARVQPEFLQT 160 170 >>NP_001305292 (OMIM: 606493) exosome complex component (152 aa) initn: 1002 init1: 764 opt: 764 Z-score: 1028.8 bits: 196.8 E(85289): 1.4e-50 Smith-Waterman score: 918; 77.4% identity (77.4% similar) in 195 aa overlap (1-195:1-152) 10 20 30 40 50 60 pF1KB6 MAPPVRYCIPGERLCNLEEGSPGSGTYTRHGYIFSSLAGCLMKSSENGALPVVSVVRETE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAPPVRYCIPGERLCNLEEGSPGSGTYTRHGYIFSSLAGCLMKSSENGALPVVSVVRETE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 SQLLPDVGAIVTCKVSSINSRFAKVHILYVGSMPLKNSFRGTIRKEDVRATEKDKVEIYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SQLLPDVGAIVTCKVSSINSRFAKVHILYVGSMPLKNSFRGTIRKEDVRATEKDKV---- 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 SFRPGDIVLAKVISLGDAQSNYLLTTAENELGVVVAHSESGIQMVPISWCEMQCPKTHTK :::::::::::::::::::: NP_001 ---------------------------------------VGIQMVPISWCEMQCPKTHTK 120 130 190 pF1KB6 EFRKVARVQPEFLQT ::::::::::::::: NP_001 EFRKVARVQPEFLQT 140 150 >>NP_001305293 (OMIM: 606493) exosome complex component (129 aa) initn: 536 init1: 536 opt: 536 Z-score: 725.1 bits: 140.4 E(85289): 1.2e-33 Smith-Waterman score: 729; 66.2% identity (66.2% similar) in 195 aa overlap (1-195:1-129) 10 20 30 40 50 60 pF1KB6 MAPPVRYCIPGERLCNLEEGSPGSGTYTRHGYIFSSLAGCLMKSSENGALPVVSVVRETE ::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAPPVRYCIPGERLCNLEEGSPGSGTYTRHGYIFSSLAGCLMKSSENGA----------- 10 20 30 40 70 80 90 100 110 120 pF1KB6 SQLLPDVGAIVTCKVSSINSRFAKVHILYVGSMPLKNSFRGTIRKEDVRATEKDKVEIYK ::::: NP_001 -------------------------------------------------------VEIYK 50 130 140 150 160 170 180 pF1KB6 SFRPGDIVLAKVISLGDAQSNYLLTTAENELGVVVAHSESGIQMVPISWCEMQCPKTHTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SFRPGDIVLAKVISLGDAQSNYLLTTAENELGVVVAHSESGIQMVPISWCEMQCPKTHTK 60 70 80 90 100 110 190 pF1KB6 EFRKVARVQPEFLQT ::::::::::::::: NP_001 EFRKVARVQPEFLQT 120 >>XP_016871793 (OMIM: 606493) PREDICTED: exosome complex (126 aa) initn: 537 init1: 525 opt: 527 Z-score: 713.2 bits: 138.1 E(85289): 5.5e-33 Smith-Waterman score: 527; 74.8% identity (85.4% similar) in 123 aa overlap (82-195:5-126) 60 70 80 90 100 pF1KB6 VVSVVRETESQLLPDVGAIVTCKVSSINSRFAKVHIL--YVGSM--P--LKNSFRG-TIR .:..: : :.. : : :.. :. . : XP_016 MARSLASIHALPKYTSCMWGPCLLRTLFEELSAR 10 20 30 110 120 130 140 150 160 pF1KB6 K--EDVRATEKDKVEIYKSFRPGDIVLAKVISLGDAQSNYLLTTAENELGVVVAHSESGI : :... : . ::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KMSEQLKKT-RLLVEIYKSFRPGDIVLAKVISLGDAQSNYLLTTAENELGVVVAHSESGI 40 50 60 70 80 90 170 180 190 pF1KB6 QMVPISWCEMQCPKTHTKEFRKVARVQPEFLQT ::::::::::::::::::::::::::::::::: XP_016 QMVPISWCEMQCPKTHTKEFRKVARVQPEFLQT 100 110 120 >>NP_001305295 (OMIM: 606493) exosome complex component (109 aa) initn: 537 init1: 525 opt: 525 Z-score: 711.5 bits: 137.6 E(85289): 6.8e-33 Smith-Waterman score: 525; 100.0% identity (100.0% similar) in 80 aa overlap (116-195:30-109) 90 100 110 120 130 140 pF1KB6 HILYVGSMPLKNSFRGTIRKEDVRATEKDKVEIYKSFRPGDIVLAKVISLGDAQSNYLLT :::::::::::::::::::::::::::::: NP_001 MWGPCLLRTLFEELSARKMSEQLKKTRLLVEIYKSFRPGDIVLAKVISLGDAQSNYLLT 10 20 30 40 50 150 160 170 180 190 pF1KB6 TAENELGVVVAHSESGIQMVPISWCEMQCPKTHTKEFRKVARVQPEFLQT :::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TAENELGVVVAHSESGIQMVPISWCEMQCPKTHTKEFRKVARVQPEFLQT 60 70 80 90 100 >>NP_001305294 (OMIM: 606493) exosome complex component (109 aa) initn: 537 init1: 525 opt: 525 Z-score: 711.5 bits: 137.6 E(85289): 6.8e-33 Smith-Waterman score: 525; 100.0% identity (100.0% similar) in 80 aa overlap (116-195:30-109) 90 100 110 120 130 140 pF1KB6 HILYVGSMPLKNSFRGTIRKEDVRATEKDKVEIYKSFRPGDIVLAKVISLGDAQSNYLLT :::::::::::::::::::::::::::::: NP_001 MWGPCLLRTLFEELSARKMSEQLKKTRLLVEIYKSFRPGDIVLAKVISLGDAQSNYLLT 10 20 30 40 50 150 160 170 180 190 pF1KB6 TAENELGVVVAHSESGIQMVPISWCEMQCPKTHTKEFRKVARVQPEFLQT :::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TAENELGVVVAHSESGIQMVPISWCEMQCPKTHTKEFRKVARVQPEFLQT 60 70 80 90 100 195 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 00:11:47 2016 done: Sat Nov 5 00:11:48 2016 Total Scan time: 3.780 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]