FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6883, 181 aa 1>>>pF1KB6883 181 - 181 aa - 181 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.9776+/-0.0003; mu= 10.2876+/- 0.019 mean_var=91.9000+/-18.246, 0's: 0 Z-trim(119.4): 164 B-trim: 717 in 1/56 Lambda= 0.133788 statistics sampled from 33177 (33360) to 33177 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.756), E-opt: 0.2 (0.391), width: 16 Scan time: 6.280 The best scores are: opt bits E(85289) NP_001005339 (OMIM: 602856) regulator of G-protein ( 181) 1176 236.2 2.2e-62 NP_002916 (OMIM: 602856) regulator of G-protein si ( 167) 1062 214.2 8.8e-56 XP_016871982 (OMIM: 602856) PREDICTED: regulator o ( 133) 575 120.1 1.4e-27 XP_016864023 (OMIM: 602512) PREDICTED: regulator o ( 509) 487 103.5 5.5e-22 NP_937870 (OMIM: 602512) regulator of G-protein si ( 799) 487 103.6 7.9e-22 XP_006713969 (OMIM: 602512) PREDICTED: regulator o (1157) 487 103.7 1.1e-21 NP_002917 (OMIM: 602512) regulator of G-protein si (1376) 487 103.8 1.2e-21 XP_006713968 (OMIM: 602512) PREDICTED: regulator o (1447) 487 103.8 1.3e-21 NP_937872 (OMIM: 602512) regulator of G-protein si (1447) 487 103.8 1.3e-21 XP_016864018 (OMIM: 602512) PREDICTED: regulator o (1447) 487 103.8 1.3e-21 XP_016871981 (OMIM: 602856) PREDICTED: regulator o ( 119) 461 98.1 5.6e-21 XP_005265852 (OMIM: 602513) PREDICTED: regulator o ( 467) 446 95.6 1.2e-19 NP_006471 (OMIM: 602513) regulator of G-protein si ( 566) 446 95.6 1.4e-19 XP_005265851 (OMIM: 602513) PREDICTED: regulator o ( 567) 446 95.6 1.4e-19 NP_002913 (OMIM: 600323) regulator of G-protein si ( 209) 364 79.5 3.8e-15 NP_001106851 (OMIM: 602516) regulator of G-protein ( 187) 362 79.1 4.5e-15 NP_005604 (OMIM: 602516) regulator of G-protein si ( 205) 362 79.1 4.8e-15 NP_570138 (OMIM: 607192) regulator of G-protein si ( 235) 362 79.2 5.4e-15 NP_001095915 (OMIM: 602516) regulator of G-protein ( 302) 362 79.2 6.6e-15 NP_001263191 (OMIM: 602189) regulator of G-protein ( 168) 356 77.9 9.2e-15 NP_602299 (OMIM: 602189) regulator of G-protein si ( 168) 356 77.9 9.2e-15 NP_652760 (OMIM: 602189) regulator of G-protein si ( 311) 356 78.1 1.5e-14 NP_001263189 (OMIM: 602189) regulator of G-protein ( 519) 356 78.2 2.3e-14 XP_011517200 (OMIM: 602189) PREDICTED: regulator o ( 519) 356 78.2 2.3e-14 XP_016870495 (OMIM: 602189) PREDICTED: regulator o ( 519) 356 78.2 2.3e-14 XP_016870494 (OMIM: 602189) PREDICTED: regulator o ( 519) 356 78.2 2.3e-14 XP_011517199 (OMIM: 602189) PREDICTED: regulator o ( 519) 356 78.2 2.3e-14 XP_011517198 (OMIM: 602189) PREDICTED: regulator o ( 519) 356 78.2 2.3e-14 NP_001269851 (OMIM: 602189) regulator of G-protein ( 519) 356 78.2 2.3e-14 XP_011517203 (OMIM: 602189) PREDICTED: regulator o ( 519) 356 78.2 2.3e-14 XP_011517202 (OMIM: 602189) PREDICTED: regulator o ( 519) 356 78.2 2.3e-14 XP_006717293 (OMIM: 602189) PREDICTED: regulator o ( 519) 356 78.2 2.3e-14 XP_006717289 (OMIM: 602189) PREDICTED: regulator o ( 519) 356 78.2 2.3e-14 XP_006717288 (OMIM: 602189) PREDICTED: regulator o ( 521) 356 78.2 2.3e-14 NP_001309144 (OMIM: 602189) regulator of G-protein ( 537) 356 78.2 2.3e-14 XP_011517196 (OMIM: 602189) PREDICTED: regulator o ( 545) 356 78.2 2.4e-14 NP_001263190 (OMIM: 602189) regulator of G-protein ( 591) 356 78.3 2.5e-14 XP_006717285 (OMIM: 602189) PREDICTED: regulator o ( 824) 356 78.4 3.3e-14 NP_570613 (OMIM: 602189) regulator of G-protein si ( 917) 356 78.4 3.6e-14 XP_016870493 (OMIM: 602189) PREDICTED: regulator o ( 961) 356 78.4 3.7e-14 XP_006717283 (OMIM: 602189) PREDICTED: regulator o (1086) 356 78.4 4.1e-14 NP_001269852 (OMIM: 602189) regulator of G-protein (1088) 356 78.4 4.1e-14 XP_006717282 (OMIM: 602189) PREDICTED: regulator o (1094) 356 78.4 4.1e-14 XP_016870492 (OMIM: 602189) PREDICTED: regulator o (1157) 356 78.5 4.3e-14 NP_652759 (OMIM: 602189) regulator of G-protein si (1198) 356 78.5 4.4e-14 NP_036551 (OMIM: 607191) regulator of G-protein si ( 210) 344 75.6 5.5e-14 XP_011508393 (OMIM: 607189) PREDICTED: regulator o ( 178) 342 75.2 6.3e-14 XP_011508392 (OMIM: 607189) PREDICTED: regulator o ( 180) 342 75.2 6.3e-14 XP_016858124 (OMIM: 607189) PREDICTED: regulator o ( 180) 342 75.2 6.3e-14 NP_001095920 (OMIM: 607189) regulator of G-protein ( 180) 342 75.2 6.3e-14 >>NP_001005339 (OMIM: 602856) regulator of G-protein sig (181 aa) initn: 1176 init1: 1176 opt: 1176 Z-score: 1240.9 bits: 236.2 E(85289): 2.2e-62 Smith-Waterman score: 1176; 100.0% identity (100.0% similar) in 181 aa overlap (1-181:1-181) 10 20 30 40 50 60 pF1KB6 MFNRAVSRLSRKRPPSDIHDSDGSSSSSHQSLKSTAKWAASLENLLEDPEGVKRFREFLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MFNRAVSRLSRKRPPSDIHDSDGSSSSSHQSLKSTAKWAASLENLLEDPEGVKRFREFLK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 KEFSEENVLFWLACEDFKKMQDKTQMQEKAKEIYMTFLSSKASSQVNVEGQSRLNEKILE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KEFSEENVLFWLACEDFKKMQDKTQMQEKAKEIYMTFLSSKASSQVNVEGQSRLNEKILE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 EPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLFLKHKRTEEEEEDLPDAQTAAKRASRIYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLFLKHKRTEEEEEDLPDAQTAAKRASRIYN 130 140 150 160 170 180 pF1KB6 T : NP_001 T >>NP_002916 (OMIM: 602856) regulator of G-protein signal (167 aa) initn: 1062 init1: 1062 opt: 1062 Z-score: 1122.5 bits: 214.2 E(85289): 8.8e-56 Smith-Waterman score: 1062; 100.0% identity (100.0% similar) in 164 aa overlap (18-181:4-167) 10 20 30 40 50 60 pF1KB6 MFNRAVSRLSRKRPPSDIHDSDGSSSSSHQSLKSTAKWAASLENLLEDPEGVKRFREFLK ::::::::::::::::::::::::::::::::::::::::::: NP_002 MEHIHDSDGSSSSSHQSLKSTAKWAASLENLLEDPEGVKRFREFLK 10 20 30 40 70 80 90 100 110 120 pF1KB6 KEFSEENVLFWLACEDFKKMQDKTQMQEKAKEIYMTFLSSKASSQVNVEGQSRLNEKILE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 KEFSEENVLFWLACEDFKKMQDKTQMQEKAKEIYMTFLSSKASSQVNVEGQSRLNEKILE 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB6 EPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLFLKHKRTEEEEEDLPDAQTAAKRASRIYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 EPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLFLKHKRTEEEEEDLPDAQTAAKRASRIYN 110 120 130 140 150 160 pF1KB6 T : NP_002 T >>XP_016871982 (OMIM: 602856) PREDICTED: regulator of G- (133 aa) initn: 579 init1: 567 opt: 575 Z-score: 615.9 bits: 120.1 E(85289): 1.4e-27 Smith-Waterman score: 765; 73.5% identity (73.5% similar) in 181 aa overlap (1-181:1-133) 10 20 30 40 50 60 pF1KB6 MFNRAVSRLSRKRPPSDIHDSDGSSSSSHQSLKSTAKWAASLENLLEDPEGVKRFREFLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MFNRAVSRLSRKRPPSDIHDSDGSSSSSHQSLKSTAKWAASLENLLEDPEGVKRFREFLK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 KEFSEENVLFWLACEDFKKMQDKTQMQEKAKEIYMTFLSSKASSQVNVEGQSRLNEKILE ::::::::::::::::::::::::: XP_016 KEFSEENVLFWLACEDFKKMQDKTQ----------------------------------- 70 80 130 140 150 160 170 180 pF1KB6 EPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLFLKHKRTEEEEEDLPDAQTAAKRASRIYN ::::::::::::::::::::::::::::::::::::::::::::::: XP_016 -------------IFNLMKYDSYSRFLKSDLFLKHKRTEEEEEDLPDAQTAAKRASRIYN 90 100 110 120 130 pF1KB6 T : XP_016 T >>XP_016864023 (OMIM: 602512) PREDICTED: regulator of G- (509 aa) initn: 479 init1: 291 opt: 487 Z-score: 515.7 bits: 103.5 E(85289): 5.5e-22 Smith-Waterman score: 487; 51.1% identity (79.1% similar) in 139 aa overlap (33-169:59-197) 10 20 30 40 50 60 pF1KB6 NRAVSRLSRKRPPSDIHDSDGSSSSSHQSLKSTAKWAASLENLLEDPEGVKRFREFLKKE . .:.::.:.: ::.:: ::. : .::.:: XP_016 GADLKDCVSNNSLSSNASLPSVQSCRRLRERRVASWAVSFERLLQDPVGVRYFSDFLRKE 30 40 50 60 70 80 70 80 90 100 110 120 pF1KB6 FSEENVLFWLACEDFKKM--QDKTQMQEKAKEIYMTFLSSKASSQVNVEGQSRLNEKILE :::::.::: ::: :... .:: ... .:.::. :: :::.. ::...:..: . .:. XP_016 FSEENILFWQACEYFNHVPAHDKKELSYRAREIFSKFLCSKATTPVNIDSQAQLADDVLR 90 100 110 120 130 140 130 140 150 160 170 180 pF1KB6 EPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLFLKHKRTEEEEEDLPDAQTAAKRASRIYN ::: ::.. : :::::::.:::.::::: :. . .: : . :::.: XP_016 APHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQECILAEVEGRALPDSQQVPSSPASKHS 150 160 170 180 190 200 pF1KB6 T XP_016 LGSDHSSVSTPKKLSGKSKSGRSLNEELGDEDSEKKRKGAFFSWSRTRSTGRSQKKREHG 210 220 230 240 250 260 >>NP_937870 (OMIM: 602512) regulator of G-protein signal (799 aa) initn: 479 init1: 291 opt: 487 Z-score: 512.9 bits: 103.6 E(85289): 7.9e-22 Smith-Waterman score: 487; 51.1% identity (79.1% similar) in 139 aa overlap (33-169:59-197) 10 20 30 40 50 60 pF1KB6 NRAVSRLSRKRPPSDIHDSDGSSSSSHQSLKSTAKWAASLENLLEDPEGVKRFREFLKKE . .:.::.:.: ::.:: ::. : .::.:: NP_937 GADLKDCVSNNSLSSNASLPSVQSCRRLRERRVASWAVSFERLLQDPVGVRYFSDFLRKE 30 40 50 60 70 80 70 80 90 100 110 120 pF1KB6 FSEENVLFWLACEDFKKM--QDKTQMQEKAKEIYMTFLSSKASSQVNVEGQSRLNEKILE :::::.::: ::: :... .:: ... .:.::. :: :::.. ::...:..: . .:. NP_937 FSEENILFWQACEYFNHVPAHDKKELSYRAREIFSKFLCSKATTPVNIDSQAQLADDVLR 90 100 110 120 130 140 130 140 150 160 170 180 pF1KB6 EPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLFLKHKRTEEEEEDLPDAQTAAKRASRIYN ::: ::.. : :::::::.:::.::::: :. . .: : . :::.: NP_937 APHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQECILAEVEGRALPDSQQVPSSPASKHS 150 160 170 180 190 200 pF1KB6 T NP_937 LGSDHSSVSTPKKLSGKSKSGRSLNEELGDEDSEKKRKGAFFSWSRTRSTGRSQKKREHG 210 220 230 240 250 260 >>XP_006713969 (OMIM: 602512) PREDICTED: regulator of G- (1157 aa) initn: 479 init1: 291 opt: 487 Z-score: 510.6 bits: 103.7 E(85289): 1.1e-21 Smith-Waterman score: 487; 51.1% identity (79.1% similar) in 139 aa overlap (33-169:707-845) 10 20 30 40 50 60 pF1KB6 NRAVSRLSRKRPPSDIHDSDGSSSSSHQSLKSTAKWAASLENLLEDPEGVKRFREFLKKE . .:.::.:.: ::.:: ::. : .::.:: XP_006 GADLKDCVSNNSLSSNASLPSVQSCRRLRERRVASWAVSFERLLQDPVGVRYFSDFLRKE 680 690 700 710 720 730 70 80 90 100 110 120 pF1KB6 FSEENVLFWLACEDFKKM--QDKTQMQEKAKEIYMTFLSSKASSQVNVEGQSRLNEKILE :::::.::: ::: :... .:: ... .:.::. :: :::.. ::...:..: . .:. XP_006 FSEENILFWQACEYFNHVPAHDKKELSYRAREIFSKFLCSKATTPVNIDSQAQLADDVLR 740 750 760 770 780 790 130 140 150 160 170 180 pF1KB6 EPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLFLKHKRTEEEEEDLPDAQTAAKRASRIYN ::: ::.. : :::::::.:::.::::: :. . .: : . :::.: XP_006 APHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQECILAEVEGRALPDSQQVPSSPASKHS 800 810 820 830 840 850 pF1KB6 T XP_006 LGSDHSSVSTPKKLSGKSKSGRSLNEELGDEDSEKKRKGAFFSWSRTRSTGRSQKKREHG 860 870 880 890 900 910 >>NP_002917 (OMIM: 602512) regulator of G-protein signal (1376 aa) initn: 479 init1: 291 opt: 487 Z-score: 509.5 bits: 103.8 E(85289): 1.2e-21 Smith-Waterman score: 487; 51.1% identity (79.1% similar) in 139 aa overlap (33-169:707-845) 10 20 30 40 50 60 pF1KB6 NRAVSRLSRKRPPSDIHDSDGSSSSSHQSLKSTAKWAASLENLLEDPEGVKRFREFLKKE . .:.::.:.: ::.:: ::. : .::.:: NP_002 GADLKDCVSNNSLSSNASLPSVQSCRRLRERRVASWAVSFERLLQDPVGVRYFSDFLRKE 680 690 700 710 720 730 70 80 90 100 110 120 pF1KB6 FSEENVLFWLACEDFKKM--QDKTQMQEKAKEIYMTFLSSKASSQVNVEGQSRLNEKILE :::::.::: ::: :... .:: ... .:.::. :: :::.. ::...:..: . .:. NP_002 FSEENILFWQACEYFNHVPAHDKKELSYRAREIFSKFLCSKATTPVNIDSQAQLADDVLR 740 750 760 770 780 790 130 140 150 160 170 180 pF1KB6 EPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLFLKHKRTEEEEEDLPDAQTAAKRASRIYN ::: ::.. : :::::::.:::.::::: :. . .: : . :::.: NP_002 APHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQECILAEVEGRALPDSQQVPSSPASKHS 800 810 820 830 840 850 pF1KB6 T NP_002 LGSDHSSVSTPKKLSGKSKSGRSLNEELGDEDSEKKRKGAFFSWSRTRSTGRSQKKREHG 860 870 880 890 900 910 >>XP_006713968 (OMIM: 602512) PREDICTED: regulator of G- (1447 aa) initn: 479 init1: 291 opt: 487 Z-score: 509.2 bits: 103.8 E(85289): 1.3e-21 Smith-Waterman score: 487; 51.1% identity (79.1% similar) in 139 aa overlap (33-169:707-845) 10 20 30 40 50 60 pF1KB6 NRAVSRLSRKRPPSDIHDSDGSSSSSHQSLKSTAKWAASLENLLEDPEGVKRFREFLKKE . .:.::.:.: ::.:: ::. : .::.:: XP_006 GADLKDCVSNNSLSSNASLPSVQSCRRLRERRVASWAVSFERLLQDPVGVRYFSDFLRKE 680 690 700 710 720 730 70 80 90 100 110 120 pF1KB6 FSEENVLFWLACEDFKKM--QDKTQMQEKAKEIYMTFLSSKASSQVNVEGQSRLNEKILE :::::.::: ::: :... .:: ... .:.::. :: :::.. ::...:..: . .:. XP_006 FSEENILFWQACEYFNHVPAHDKKELSYRAREIFSKFLCSKATTPVNIDSQAQLADDVLR 740 750 760 770 780 790 130 140 150 160 170 180 pF1KB6 EPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLFLKHKRTEEEEEDLPDAQTAAKRASRIYN ::: ::.. : :::::::.:::.::::: :. . .: : . :::.: XP_006 APHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQECILAEVEGRALPDSQQVPSSPASKHS 800 810 820 830 840 850 pF1KB6 T XP_006 LGSDHSSVSTPKKLSGKSKSGRSLNEELGDEDSEKKRKGAFFSWSRTRSTGRSQKKREHG 860 870 880 890 900 910 >>NP_937872 (OMIM: 602512) regulator of G-protein signal (1447 aa) initn: 479 init1: 291 opt: 487 Z-score: 509.2 bits: 103.8 E(85289): 1.3e-21 Smith-Waterman score: 487; 51.1% identity (79.1% similar) in 139 aa overlap (33-169:707-845) 10 20 30 40 50 60 pF1KB6 NRAVSRLSRKRPPSDIHDSDGSSSSSHQSLKSTAKWAASLENLLEDPEGVKRFREFLKKE . .:.::.:.: ::.:: ::. : .::.:: NP_937 GADLKDCVSNNSLSSNASLPSVQSCRRLRERRVASWAVSFERLLQDPVGVRYFSDFLRKE 680 690 700 710 720 730 70 80 90 100 110 120 pF1KB6 FSEENVLFWLACEDFKKM--QDKTQMQEKAKEIYMTFLSSKASSQVNVEGQSRLNEKILE :::::.::: ::: :... .:: ... .:.::. :: :::.. ::...:..: . .:. NP_937 FSEENILFWQACEYFNHVPAHDKKELSYRAREIFSKFLCSKATTPVNIDSQAQLADDVLR 740 750 760 770 780 790 130 140 150 160 170 180 pF1KB6 EPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLFLKHKRTEEEEEDLPDAQTAAKRASRIYN ::: ::.. : :::::::.:::.::::: :. . .: : . :::.: NP_937 APHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQECILAEVEGRALPDSQQVPSSPASKHS 800 810 820 830 840 850 pF1KB6 T NP_937 LGSDHSSVSTPKKLSGKSKSGRSLNEELGDEDSEKKRKGAFFSWSRTRSTGRSQKKREHG 860 870 880 890 900 910 >>XP_016864018 (OMIM: 602512) PREDICTED: regulator of G- (1447 aa) initn: 479 init1: 291 opt: 487 Z-score: 509.2 bits: 103.8 E(85289): 1.3e-21 Smith-Waterman score: 487; 51.1% identity (79.1% similar) in 139 aa overlap (33-169:707-845) 10 20 30 40 50 60 pF1KB6 NRAVSRLSRKRPPSDIHDSDGSSSSSHQSLKSTAKWAASLENLLEDPEGVKRFREFLKKE . .:.::.:.: ::.:: ::. : .::.:: XP_016 GADLKDCVSNNSLSSNASLPSVQSCRRLRERRVASWAVSFERLLQDPVGVRYFSDFLRKE 680 690 700 710 720 730 70 80 90 100 110 120 pF1KB6 FSEENVLFWLACEDFKKM--QDKTQMQEKAKEIYMTFLSSKASSQVNVEGQSRLNEKILE :::::.::: ::: :... .:: ... .:.::. :: :::.. ::...:..: . .:. XP_016 FSEENILFWQACEYFNHVPAHDKKELSYRAREIFSKFLCSKATTPVNIDSQAQLADDVLR 740 750 760 770 780 790 130 140 150 160 170 180 pF1KB6 EPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLFLKHKRTEEEEEDLPDAQTAAKRASRIYN ::: ::.. : :::::::.:::.::::: :. . .: : . :::.: XP_016 APHPDMFKEQQLQIFNLMKFDSYTRFLKSPLYQECILAEVEGRALPDSQQVPSSPASKHS 800 810 820 830 840 850 pF1KB6 T XP_016 LGSDHSSVSTPKKLSGKSKSGRSLNEELGDEDSEKKRKGAFFSWSRTRSTGRSQKKREHG 860 870 880 890 900 910 181 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 20:28:27 2016 done: Sat Nov 5 20:28:28 2016 Total Scan time: 6.280 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]