FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6889, 183 aa 1>>>pF1KB6889 183 - 183 aa - 183 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.5900+/-0.000432; mu= 17.2564+/- 0.027 mean_var=74.3414+/-15.099, 0's: 0 Z-trim(113.1): 432 B-trim: 1193 in 2/48 Lambda= 0.148751 statistics sampled from 21766 (22288) to 21766 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.647), E-opt: 0.2 (0.261), width: 16 Scan time: 5.120 The best scores are: opt bits E(85289) NP_002877 (OMIM: 179541) ras-related protein Rap-2 ( 183) 1196 265.6 3.1e-71 NP_066361 (OMIM: 179540) ras-related protein Rap-2 ( 183) 1089 242.7 2.5e-64 NP_001010942 (OMIM: 179530) ras-related protein Ra ( 184) 741 168.0 7.7e-42 NP_056461 (OMIM: 179530) ras-related protein Rap-1 ( 184) 741 168.0 7.7e-42 NP_001010935 (OMIM: 179520) ras-related protein Ra ( 184) 737 167.1 1.4e-41 NP_001278825 (OMIM: 179520) ras-related protein Ra ( 184) 737 167.1 1.4e-41 NP_002875 (OMIM: 179520) ras-related protein Rap-1 ( 184) 737 167.1 1.4e-41 XP_016857451 (OMIM: 179520) PREDICTED: ras-related ( 184) 737 167.1 1.4e-41 XP_016857452 (OMIM: 179520) PREDICTED: ras-related ( 184) 737 167.1 1.4e-41 XP_016857453 (OMIM: 179520) PREDICTED: ras-related ( 184) 737 167.1 1.4e-41 XP_016857449 (OMIM: 179520) PREDICTED: ras-related ( 195) 692 157.5 1.2e-38 XP_016857450 (OMIM: 179520) PREDICTED: ras-related ( 195) 692 157.5 1.2e-38 NP_008843 (OMIM: 609591,615355) GTP-binding protei ( 219) 573 132.0 6.2e-31 NP_001243750 (OMIM: 609591,615355) GTP-binding pro ( 236) 573 132.0 6.5e-31 NP_004976 (OMIM: 109800,114480,137215,163200,19007 ( 188) 568 130.9 1.2e-30 XP_011518955 (OMIM: 109800,114480,137215,163200,19 ( 188) 568 130.9 1.2e-30 NP_002515 (OMIM: 114500,137550,162900,163200,16479 ( 189) 568 130.9 1.2e-30 NP_203524 (OMIM: 109800,114480,137215,163200,19007 ( 189) 565 130.2 1.8e-30 XP_006719132 (OMIM: 109800,114480,137215,163200,19 ( 189) 565 130.2 1.8e-30 XP_016874782 (OMIM: 109800,114480,137215,163200,19 ( 227) 565 130.3 2.1e-30 NP_002921 (OMIM: 609592) GTP-binding protein Rit2 ( 217) 560 129.2 4.3e-30 NP_005334 (OMIM: 109800,137550,162900,163200,18847 ( 189) 553 127.7 1.1e-29 NP_001123914 (OMIM: 109800,137550,162900,163200,18 ( 189) 553 127.7 1.1e-29 NP_036382 (OMIM: 600098) ras-related protein R-Ras ( 204) 539 124.7 9.3e-29 XP_006715825 (OMIM: 179550) PREDICTED: ras-related ( 206) 533 123.4 2.3e-28 NP_005393 (OMIM: 179550) ras-related protein Ral-A ( 206) 533 123.4 2.3e-28 XP_011513768 (OMIM: 179550) PREDICTED: ras-related ( 206) 533 123.4 2.3e-28 XP_016860111 (OMIM: 179551) PREDICTED: ras-related ( 206) 524 121.5 8.7e-28 NP_002872 (OMIM: 179551) ras-related protein Ral-B ( 206) 524 121.5 8.7e-28 XP_005263784 (OMIM: 179551) PREDICTED: ras-related ( 206) 524 121.5 8.7e-28 XP_005263785 (OMIM: 179551) PREDICTED: ras-related ( 206) 524 121.5 8.7e-28 XP_005263786 (OMIM: 179551) PREDICTED: ras-related ( 206) 524 121.5 8.7e-28 XP_005263781 (OMIM: 179551) PREDICTED: ras-related ( 228) 524 121.5 9.4e-28 XP_016860110 (OMIM: 179551) PREDICTED: ras-related ( 228) 524 121.5 9.4e-28 XP_011509875 (OMIM: 179551) PREDICTED: ras-related ( 229) 524 121.5 9.4e-28 NP_789765 (OMIM: 109800,137550,162900,163200,18847 ( 170) 521 120.7 1.2e-27 NP_060064 (OMIM: 607863) GTP-binding protein Di-Ra ( 199) 515 119.5 3.3e-27 NP_036351 (OMIM: 608435) ras-related protein M-Ras ( 208) 513 119.1 4.5e-27 XP_016861376 (OMIM: 608435) PREDICTED: ras-related ( 208) 513 119.1 4.5e-27 NP_001078518 (OMIM: 608435) ras-related protein M- ( 208) 513 119.1 4.5e-27 XP_005247285 (OMIM: 608435) PREDICTED: ras-related ( 208) 513 119.1 4.5e-27 NP_001239019 (OMIM: 608435) ras-related protein M- ( 208) 513 119.1 4.5e-27 NP_006261 (OMIM: 165090) ras-related protein R-Ras ( 218) 511 118.7 6.3e-27 NP_660156 (OMIM: 607862) GTP-binding protein Di-Ra ( 198) 504 117.2 1.7e-26 XP_011526015 (OMIM: 607862) PREDICTED: GTP-binding ( 232) 504 117.2 1.9e-26 NP_001243749 (OMIM: 609591,615355) GTP-binding pro ( 183) 480 112.0 5.6e-25 NP_001259006 (OMIM: 609592) GTP-binding protein Ri ( 153) 457 107.0 1.5e-23 XP_005247286 (OMIM: 608435) PREDICTED: ras-related ( 170) 451 105.7 4e-23 NP_005605 (OMIM: 601293) GTP-binding protein Rheb ( 184) 441 103.6 1.9e-22 NP_116307 (OMIM: 612664) ras-related and estrogen- ( 199) 440 103.4 2.3e-22 >>NP_002877 (OMIM: 179541) ras-related protein Rap-2b [H (183 aa) initn: 1196 init1: 1196 opt: 1196 Z-score: 1399.8 bits: 265.6 E(85289): 3.1e-71 Smith-Waterman score: 1196; 100.0% identity (100.0% similar) in 183 aa overlap (1-183:1-183) 10 20 30 40 50 60 pF1KB6 MREYKVVVLGSGGVGKSALTVQFVTGSFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MREYKVVVLGSGGVGKSALTVQFVTGSFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYERVPMILVGNKVDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYERVPMILVGNKVDL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 EGEREVSYGEGKALAEEWSCPFMETSAKNKASVDELFAEIVRQMNYAAQPNGDEGCCSAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 EGEREVSYGEGKALAEEWSCPFMETSAKNKASVDELFAEIVRQMNYAAQPNGDEGCCSAC 130 140 150 160 170 180 pF1KB6 VIL ::: NP_002 VIL >>NP_066361 (OMIM: 179540) ras-related protein Rap-2a pr (183 aa) initn: 1106 init1: 1089 opt: 1089 Z-score: 1275.7 bits: 242.7 E(85289): 2.5e-64 Smith-Waterman score: 1089; 91.2% identity (97.3% similar) in 182 aa overlap (1-182:1-182) 10 20 30 40 50 60 pF1KB6 MREYKVVVLGSGGVGKSALTVQFVTGSFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG ::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::: NP_066 MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYERVPMILVGNKVDL :::::::::::::::::::::::::::::::::::::::::::::::.::.::::::::: NP_066 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYEKVPVILVGNKVDL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 EGEREVSYGEGKALAEEWSCPFMETSAKNKASVDELFAEIVRQMNYAAQPNGDEGCCSAC :.::::: .::.::::::.:::::::::.:. ::::::::::::::::::. :. ::::: NP_066 ESEREVSSSEGRALAEEWGCPFMETSAKSKTMVDELFAEIVRQMNYAAQPDKDDPCCSAC 130 140 150 160 170 180 pF1KB6 VIL : NP_066 NIQ >>NP_001010942 (OMIM: 179530) ras-related protein Rap-1b (184 aa) initn: 696 init1: 634 opt: 741 Z-score: 872.1 bits: 168.0 E(85289): 7.7e-42 Smith-Waterman score: 741; 61.4% identity (82.6% similar) in 184 aa overlap (1-183:1-184) 10 20 30 40 50 60 pF1KB6 MREYKVVVLGSGGVGKSALTVQFVTGSFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG :::::.:::::::::::::::::: : :.::::::::: :::..:::.. .:::::::: NP_001 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYERVPMILVGNKVDL ::::..:::::.:::::: ::::.. :..:.:.. .:.::.::: . ::::::::: :: NP_001 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDL 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 EGEREVSYGEGKALAEEWS-CPFMETSAKNKASVDELFAEIVRQMNYAAQPNGDEGCCSA : :: :. .:. ::..:. : :.:.:::.: .:.:.: ..:::.: . : :. NP_001 EDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKKSS 130 140 150 160 170 180 180 pF1KB6 CVIL : .: NP_001 CQLL >>NP_056461 (OMIM: 179530) ras-related protein Rap-1b is (184 aa) initn: 696 init1: 634 opt: 741 Z-score: 872.1 bits: 168.0 E(85289): 7.7e-42 Smith-Waterman score: 741; 61.4% identity (82.6% similar) in 184 aa overlap (1-183:1-184) 10 20 30 40 50 60 pF1KB6 MREYKVVVLGSGGVGKSALTVQFVTGSFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG :::::.:::::::::::::::::: : :.::::::::: :::..:::.. .:::::::: NP_056 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYERVPMILVGNKVDL ::::..:::::.:::::: ::::.. :..:.:.. .:.::.::: . ::::::::: :: NP_056 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDL 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 EGEREVSYGEGKALAEEWS-CPFMETSAKNKASVDELFAEIVRQMNYAAQPNGDEGCCSA : :: :. .:. ::..:. : :.:.:::.: .:.:.: ..:::.: . : :. NP_056 EDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKKSS 130 140 150 160 170 180 180 pF1KB6 CVIL : .: NP_056 CQLL >>NP_001010935 (OMIM: 179520) ras-related protein Rap-1A (184 aa) initn: 697 init1: 635 opt: 737 Z-score: 867.5 bits: 167.1 E(85289): 1.4e-41 Smith-Waterman score: 737; 60.9% identity (83.2% similar) in 184 aa overlap (1-183:1-184) 10 20 30 40 50 60 pF1KB6 MREYKVVVLGSGGVGKSALTVQFVTGSFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG :::::.:::::::::::::::::: : :.::::::::: :::..::: . .:::::::: NP_001 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYERVPMILVGNKVDL ::::..:::::.:::::: ::::.. :..:.:.. .:.::.::: : ::::::::: :: NP_001 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDL 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 EGEREVSYGEGKALAEEW-SCPFMETSAKNKASVDELFAEIVRQMNYAAQPNGDEGCCSA : :: :. .:. ::..: .: :.:.:::.: .:.:.: ..:::.: . . . .. NP_001 EDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKS 130 140 150 160 170 180 180 pF1KB6 CVIL :..: NP_001 CLLL >>NP_001278825 (OMIM: 179520) ras-related protein Rap-1A (184 aa) initn: 697 init1: 635 opt: 737 Z-score: 867.5 bits: 167.1 E(85289): 1.4e-41 Smith-Waterman score: 737; 60.9% identity (83.2% similar) in 184 aa overlap (1-183:1-184) 10 20 30 40 50 60 pF1KB6 MREYKVVVLGSGGVGKSALTVQFVTGSFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG :::::.:::::::::::::::::: : :.::::::::: :::..::: . .:::::::: NP_001 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYERVPMILVGNKVDL ::::..:::::.:::::: ::::.. :..:.:.. .:.::.::: : ::::::::: :: NP_001 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDL 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 EGEREVSYGEGKALAEEW-SCPFMETSAKNKASVDELFAEIVRQMNYAAQPNGDEGCCSA : :: :. .:. ::..: .: :.:.:::.: .:.:.: ..:::.: . . . .. NP_001 EDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKS 130 140 150 160 170 180 180 pF1KB6 CVIL :..: NP_001 CLLL >>NP_002875 (OMIM: 179520) ras-related protein Rap-1A pr (184 aa) initn: 697 init1: 635 opt: 737 Z-score: 867.5 bits: 167.1 E(85289): 1.4e-41 Smith-Waterman score: 737; 60.9% identity (83.2% similar) in 184 aa overlap (1-183:1-184) 10 20 30 40 50 60 pF1KB6 MREYKVVVLGSGGVGKSALTVQFVTGSFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG :::::.:::::::::::::::::: : :.::::::::: :::..::: . .:::::::: NP_002 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYERVPMILVGNKVDL ::::..:::::.:::::: ::::.. :..:.:.. .:.::.::: : ::::::::: :: NP_002 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDL 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 EGEREVSYGEGKALAEEW-SCPFMETSAKNKASVDELFAEIVRQMNYAAQPNGDEGCCSA : :: :. .:. ::..: .: :.:.:::.: .:.:.: ..:::.: . . . .. NP_002 EDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKS 130 140 150 160 170 180 180 pF1KB6 CVIL :..: NP_002 CLLL >>XP_016857451 (OMIM: 179520) PREDICTED: ras-related pro (184 aa) initn: 697 init1: 635 opt: 737 Z-score: 867.5 bits: 167.1 E(85289): 1.4e-41 Smith-Waterman score: 737; 60.9% identity (83.2% similar) in 184 aa overlap (1-183:1-184) 10 20 30 40 50 60 pF1KB6 MREYKVVVLGSGGVGKSALTVQFVTGSFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG :::::.:::::::::::::::::: : :.::::::::: :::..::: . .:::::::: XP_016 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYERVPMILVGNKVDL ::::..:::::.:::::: ::::.. :..:.:.. .:.::.::: : ::::::::: :: XP_016 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDL 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 EGEREVSYGEGKALAEEW-SCPFMETSAKNKASVDELFAEIVRQMNYAAQPNGDEGCCSA : :: :. .:. ::..: .: :.:.:::.: .:.:.: ..:::.: . . . .. XP_016 EDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKS 130 140 150 160 170 180 180 pF1KB6 CVIL :..: XP_016 CLLL >>XP_016857452 (OMIM: 179520) PREDICTED: ras-related pro (184 aa) initn: 697 init1: 635 opt: 737 Z-score: 867.5 bits: 167.1 E(85289): 1.4e-41 Smith-Waterman score: 737; 60.9% identity (83.2% similar) in 184 aa overlap (1-183:1-184) 10 20 30 40 50 60 pF1KB6 MREYKVVVLGSGGVGKSALTVQFVTGSFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG :::::.:::::::::::::::::: : :.::::::::: :::..::: . .:::::::: XP_016 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYERVPMILVGNKVDL ::::..:::::.:::::: ::::.. :..:.:.. .:.::.::: : ::::::::: :: XP_016 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDL 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 EGEREVSYGEGKALAEEW-SCPFMETSAKNKASVDELFAEIVRQMNYAAQPNGDEGCCSA : :: :. .:. ::..: .: :.:.:::.: .:.:.: ..:::.: . . . .. XP_016 EDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKS 130 140 150 160 170 180 180 pF1KB6 CVIL :..: XP_016 CLLL >>XP_016857453 (OMIM: 179520) PREDICTED: ras-related pro (184 aa) initn: 697 init1: 635 opt: 737 Z-score: 867.5 bits: 167.1 E(85289): 1.4e-41 Smith-Waterman score: 737; 60.9% identity (83.2% similar) in 184 aa overlap (1-183:1-184) 10 20 30 40 50 60 pF1KB6 MREYKVVVLGSGGVGKSALTVQFVTGSFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG :::::.:::::::::::::::::: : :.::::::::: :::..::: . .:::::::: XP_016 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYERVPMILVGNKVDL ::::..:::::.:::::: ::::.. :..:.:.. .:.::.::: : ::::::::: :: XP_016 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDL 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 EGEREVSYGEGKALAEEW-SCPFMETSAKNKASVDELFAEIVRQMNYAAQPNGDEGCCSA : :: :. .:. ::..: .: :.:.:::.: .:.:.: ..:::.: . . . .. XP_016 EDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKS 130 140 150 160 170 180 180 pF1KB6 CVIL :..: XP_016 CLLL 183 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 00:19:28 2016 done: Sat Nov 5 00:19:29 2016 Total Scan time: 5.120 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]