FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6892, 202 aa 1>>>pF1KB6892 202 - 202 aa - 202 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.4538+/-0.000329; mu= -8.3314+/- 0.021 mean_var=335.4084+/-68.621, 0's: 0 Z-trim(126.1): 27 B-trim: 1650 in 1/58 Lambda= 0.070031 statistics sampled from 51337 (51369) to 51337 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.857), E-opt: 0.2 (0.602), width: 16 Scan time: 7.770 The best scores are: opt bits E(85289) NP_000942 (OMIM: 604429) transmembrane gamma-carbo ( 202) 1441 157.7 1.2e-38 XP_006723349 (OMIM: 604429) PREDICTED: transmembra ( 202) 1441 157.7 1.2e-38 XP_011525426 (OMIM: 604429) PREDICTED: transmembra ( 179) 1256 139.0 4.5e-33 NP_001303264 (OMIM: 604429) transmembrane gamma-ca ( 179) 1256 139.0 4.5e-33 NP_076986 (OMIM: 611690) transmembrane gamma-carbo ( 226) 299 42.4 0.00069 XP_006718377 (OMIM: 611690) PREDICTED: transmembra ( 226) 299 42.4 0.00069 XP_016873764 (OMIM: 611690) PREDICTED: transmembra ( 364) 299 42.6 0.00097 >>NP_000942 (OMIM: 604429) transmembrane gamma-carboxygl (202 aa) initn: 1441 init1: 1441 opt: 1441 Z-score: 815.0 bits: 157.7 E(85289): 1.2e-38 Smith-Waterman score: 1441; 100.0% identity (100.0% similar) in 202 aa overlap (1-202:1-202) 10 20 30 40 50 60 pF1KB6 MRGHPSLLLLYMALTTCLDTSPSEETDQEVFLGPPEAQSFLSSHTRIPRANHWDLELLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MRGHPSLLLLYMALTTCLDTSPSEETDQEVFLGPPEAQSFLSSHTRIPRANHWDLELLTP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 GNLERECLEERCSWEEAREYFEDNTLTERFWESYIYNGKGGRGRVDVASLAVGLTGGILL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 GNLERECLEERCSWEEAREYFEDNTLTERFWESYIYNGKGGRGRVDVASLAVGLTGGILL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 IVLAGLGAFWYLRWRQHRGQQPCPQEAGLISPLSPLNPLGPPTPLPPPPPPPPGLPTYEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 IVLAGLGAFWYLRWRQHRGQQPCPQEAGLISPLSPLNPLGPPTPLPPPPPPPPGLPTYEQ 130 140 150 160 170 180 190 200 pF1KB6 ALAASGVHDAPPPPYTSLRRPH :::::::::::::::::::::: NP_000 ALAASGVHDAPPPPYTSLRRPH 190 200 >>XP_006723349 (OMIM: 604429) PREDICTED: transmembrane g (202 aa) initn: 1441 init1: 1441 opt: 1441 Z-score: 815.0 bits: 157.7 E(85289): 1.2e-38 Smith-Waterman score: 1441; 100.0% identity (100.0% similar) in 202 aa overlap (1-202:1-202) 10 20 30 40 50 60 pF1KB6 MRGHPSLLLLYMALTTCLDTSPSEETDQEVFLGPPEAQSFLSSHTRIPRANHWDLELLTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MRGHPSLLLLYMALTTCLDTSPSEETDQEVFLGPPEAQSFLSSHTRIPRANHWDLELLTP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 GNLERECLEERCSWEEAREYFEDNTLTERFWESYIYNGKGGRGRVDVASLAVGLTGGILL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GNLERECLEERCSWEEAREYFEDNTLTERFWESYIYNGKGGRGRVDVASLAVGLTGGILL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 IVLAGLGAFWYLRWRQHRGQQPCPQEAGLISPLSPLNPLGPPTPLPPPPPPPPGLPTYEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IVLAGLGAFWYLRWRQHRGQQPCPQEAGLISPLSPLNPLGPPTPLPPPPPPPPGLPTYEQ 130 140 150 160 170 180 190 200 pF1KB6 ALAASGVHDAPPPPYTSLRRPH :::::::::::::::::::::: XP_006 ALAASGVHDAPPPPYTSLRRPH 190 200 >>XP_011525426 (OMIM: 604429) PREDICTED: transmembrane g (179 aa) initn: 1256 init1: 1256 opt: 1256 Z-score: 714.7 bits: 139.0 E(85289): 4.5e-33 Smith-Waterman score: 1256; 100.0% identity (100.0% similar) in 174 aa overlap (29-202:6-179) 10 20 30 40 50 60 pF1KB6 MRGHPSLLLLYMALTTCLDTSPSEETDQEVFLGPPEAQSFLSSHTRIPRANHWDLELLTP :::::::::::::::::::::::::::::::: XP_011 MSLGPEVFLGPPEAQSFLSSHTRIPRANHWDLELLTP 10 20 30 70 80 90 100 110 120 pF1KB6 GNLERECLEERCSWEEAREYFEDNTLTERFWESYIYNGKGGRGRVDVASLAVGLTGGILL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GNLERECLEERCSWEEAREYFEDNTLTERFWESYIYNGKGGRGRVDVASLAVGLTGGILL 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB6 IVLAGLGAFWYLRWRQHRGQQPCPQEAGLISPLSPLNPLGPPTPLPPPPPPPPGLPTYEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IVLAGLGAFWYLRWRQHRGQQPCPQEAGLISPLSPLNPLGPPTPLPPPPPPPPGLPTYEQ 100 110 120 130 140 150 190 200 pF1KB6 ALAASGVHDAPPPPYTSLRRPH :::::::::::::::::::::: XP_011 ALAASGVHDAPPPPYTSLRRPH 160 170 >>NP_001303264 (OMIM: 604429) transmembrane gamma-carbox (179 aa) initn: 1256 init1: 1256 opt: 1256 Z-score: 714.7 bits: 139.0 E(85289): 4.5e-33 Smith-Waterman score: 1256; 100.0% identity (100.0% similar) in 174 aa overlap (29-202:6-179) 10 20 30 40 50 60 pF1KB6 MRGHPSLLLLYMALTTCLDTSPSEETDQEVFLGPPEAQSFLSSHTRIPRANHWDLELLTP :::::::::::::::::::::::::::::::: NP_001 MSLGPEVFLGPPEAQSFLSSHTRIPRANHWDLELLTP 10 20 30 70 80 90 100 110 120 pF1KB6 GNLERECLEERCSWEEAREYFEDNTLTERFWESYIYNGKGGRGRVDVASLAVGLTGGILL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GNLERECLEERCSWEEAREYFEDNTLTERFWESYIYNGKGGRGRVDVASLAVGLTGGILL 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB6 IVLAGLGAFWYLRWRQHRGQQPCPQEAGLISPLSPLNPLGPPTPLPPPPPPPPGLPTYEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVLAGLGAFWYLRWRQHRGQQPCPQEAGLISPLSPLNPLGPPTPLPPPPPPPPGLPTYEQ 100 110 120 130 140 150 190 200 pF1KB6 ALAASGVHDAPPPPYTSLRRPH :::::::::::::::::::::: NP_001 ALAASGVHDAPPPPYTSLRRPH 160 170 >>NP_076986 (OMIM: 611690) transmembrane gamma-carboxygl (226 aa) initn: 310 init1: 193 opt: 299 Z-score: 190.8 bits: 42.4 E(85289): 0.00069 Smith-Waterman score: 380; 40.5% identity (63.8% similar) in 185 aa overlap (23-195:28-207) 10 20 30 40 50 pF1KB6 MRGHPSLLLLYMALTTCLDTSPSEETDQEVFLGPPEAQSFLSSHTRIPRANHWDL :... .::: . ::. :. : :. :..:: NP_076 MFTLLVLLSQLPTVTLGFPHCARGPKASKHAGEEVFTSKEEANFFI--HRRL-LYNRFDL 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 ELLTPGNLERECLEERCSWEEAREYFEDNTLTERFWESYIYNGK-----GGRGRVDVASL ::.::::::::: :: :..::::: : :. : ::. : .: :.: ..:: .: NP_076 ELFTPGNLERECNEELCNYEEAREIFVDEDKTIAFWQEYSAKGPTTKSDGNREKIDVMGL 60 70 80 90 100 110 120 130 140 150 160 pF1KB6 AVGL-TGGILLIVLAGLGAFWYLRWRQHRGQQPCPQ---EAGLISPLSPLNPLGPPTPLP .:: ..:..:.... :: . . . .: :.:: . : : .: : . . : NP_076 LTGLIAAGVFLVIFGLLGYYLCIT-KCNRLQHPCSSAVYERGRHTP-SIIFRRPEEAALS 120 130 140 150 160 170 170 180 190 200 pF1KB6 PPPPP--PPGLPTYEQALAASGVHD-APPPPYTSLRRPH : :: :::.::::.: . :. .::::: NP_076 PLPPSVEDAGLPSYEQAVALTRKHSVSPPPPYPGHTKGFRVFKKSMSLPSH 180 190 200 210 220 >>XP_006718377 (OMIM: 611690) PREDICTED: transmembrane g (226 aa) initn: 310 init1: 193 opt: 299 Z-score: 190.8 bits: 42.4 E(85289): 0.00069 Smith-Waterman score: 380; 40.5% identity (63.8% similar) in 185 aa overlap (23-195:28-207) 10 20 30 40 50 pF1KB6 MRGHPSLLLLYMALTTCLDTSPSEETDQEVFLGPPEAQSFLSSHTRIPRANHWDL :... .::: . ::. :. : :. :..:: XP_006 MFTLLVLLSQLPTVTLGFPHCARGPKASKHAGEEVFTSKEEANFFI--HRRL-LYNRFDL 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 ELLTPGNLERECLEERCSWEEAREYFEDNTLTERFWESYIYNGK-----GGRGRVDVASL ::.::::::::: :: :..::::: : :. : ::. : .: :.: ..:: .: XP_006 ELFTPGNLERECNEELCNYEEAREIFVDEDKTIAFWQEYSAKGPTTKSDGNREKIDVMGL 60 70 80 90 100 110 120 130 140 150 160 pF1KB6 AVGL-TGGILLIVLAGLGAFWYLRWRQHRGQQPCPQ---EAGLISPLSPLNPLGPPTPLP .:: ..:..:.... :: . . . .: :.:: . : : .: : . . : XP_006 LTGLIAAGVFLVIFGLLGYYLCIT-KCNRLQHPCSSAVYERGRHTP-SIIFRRPEEAALS 120 130 140 150 160 170 170 180 190 200 pF1KB6 PPPPP--PPGLPTYEQALAASGVHD-APPPPYTSLRRPH : :: :::.::::.: . :. .::::: XP_006 PLPPSVEDAGLPSYEQAVALTRKHSVSPPPPYPGHTKGFRVFKKSMSLPSH 180 190 200 210 220 >>XP_016873764 (OMIM: 611690) PREDICTED: transmembrane g (364 aa) initn: 310 init1: 193 opt: 299 Z-score: 188.1 bits: 42.6 E(85289): 0.00097 Smith-Waterman score: 380; 40.5% identity (63.8% similar) in 185 aa overlap (23-195:166-345) 10 20 30 40 50 pF1KB6 MRGHPSLLLLYMALTTCLDTSPSEETDQEVFLGPPEAQSFLSSHTRIPRANH :... .::: . ::. :. : :. :. XP_016 CQTMFTLLVLLSQLPTVTLGFPHCARGPKASKHAGEEVFTSKEEANFFI--HRRL-LYNR 140 150 160 170 180 190 60 70 80 90 100 pF1KB6 WDLELLTPGNLERECLEERCSWEEAREYFEDNTLTERFWESYIYNGK-----GGRGRVDV .::::.::::::::: :: :..::::: : :. : ::. : .: :.: ..:: XP_016 FDLELFTPGNLERECNEELCNYEEAREIFVDEDKTIAFWQEYSAKGPTTKSDGNREKIDV 200 210 220 230 240 250 110 120 130 140 150 160 pF1KB6 ASLAVGL-TGGILLIVLAGLGAFWYLRWRQHRGQQPCPQ---EAGLISPLSPLNPLGPPT .: .:: ..:..:.... :: . . . .: :.:: . : : .: : . . XP_016 MGLLTGLIAAGVFLVIFGLLGYYLCIT-KCNRLQHPCSSAVYERGRHTP-SIIFRRPEEA 260 270 280 290 300 310 170 180 190 200 pF1KB6 PLPPPPPP--PPGLPTYEQALAASGVHD-APPPPYTSLRRPH : : :: :::.::::.: . :. .::::: XP_016 ALSPLPPSVEDAGLPSYEQAVALTRKHSVSPPPPYPGHTKGFRVFKKSMSLPSH 320 330 340 350 360 202 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 14:08:24 2016 done: Sat Nov 5 14:08:25 2016 Total Scan time: 7.770 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]