FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6895, 184 aa 1>>>pF1KB6895 184 - 184 aa - 184 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.0459+/-0.00122; mu= 8.3980+/- 0.073 mean_var=72.6791+/-14.746, 0's: 0 Z-trim(101.0): 194 B-trim: 202 in 1/48 Lambda= 0.150442 statistics sampled from 6108 (6327) to 6108 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.551), E-opt: 0.2 (0.194), width: 16 Scan time: 1.670 The best scores are: opt bits E(32554) CCDS5927.1 RHEB gene_id:6009|Hs108|chr7 ( 184) 1162 261.8 1.7e-70 CCDS8778.1 RHEBL1 gene_id:121268|Hs108|chr12 ( 183) 657 152.2 1.7e-37 CCDS3170.1 RAP2B gene_id:5912|Hs108|chr3 ( 183) 441 105.3 2.2e-23 CCDS8984.1 RAP1B gene_id:5908|Hs108|chr12 ( 184) 441 105.3 2.2e-23 CCDS9485.1 RAP2A gene_id:5911|Hs108|chr13 ( 183) 430 102.9 1.2e-22 CCDS840.1 RAP1A gene_id:5906|Hs108|chr1 ( 184) 426 102.0 2.1e-22 CCDS14632.1 RAP2C gene_id:57826|Hs108|chrX ( 183) 409 98.3 2.7e-21 CCDS6687.1 DIRAS2 gene_id:54769|Hs108|chr9 ( 199) 404 97.3 6.2e-21 CCDS8702.1 KRAS gene_id:3845|Hs108|chr12 ( 188) 393 94.9 3.1e-20 CCDS12774.1 RRAS gene_id:6237|Hs108|chr19 ( 218) 385 93.2 1.2e-19 CCDS12092.1 DIRAS1 gene_id:148252|Hs108|chr19 ( 198) 383 92.7 1.5e-19 CCDS5460.1 RALA gene_id:5898|Hs108|chr7 ( 206) 382 92.5 1.8e-19 CCDS7814.1 RRAS2 gene_id:22800|Hs108|chr11 ( 204) 378 91.6 3.2e-19 CCDS8703.1 KRAS gene_id:3845|Hs108|chr12 ( 189) 377 91.4 3.5e-19 CCDS877.1 NRAS gene_id:4893|Hs108|chr1 ( 189) 373 90.5 6.3e-19 CCDS3100.1 MRAS gene_id:22808|Hs108|chr3 ( 208) 373 90.6 6.9e-19 CCDS11921.1 RIT2 gene_id:6014|Hs108|chr18 ( 217) 373 90.6 7.1e-19 CCDS7698.1 HRAS gene_id:3265|Hs108|chr11 ( 189) 371 90.1 8.5e-19 CCDS2131.1 RALB gene_id:5899|Hs108|chr2 ( 206) 358 87.3 6.5e-18 CCDS7699.1 HRAS gene_id:3265|Hs108|chr11 ( 170) 352 86.0 1.3e-17 CCDS1123.1 RIT1 gene_id:6016|Hs108|chr1 ( 219) 348 85.1 3.1e-17 CCDS58037.1 RIT1 gene_id:6016|Hs108|chr1 ( 236) 348 85.1 3.3e-17 CCDS9003.1 RAB21 gene_id:23011|Hs108|chr12 ( 225) 331 81.4 4.1e-16 CCDS2520.1 RAB17 gene_id:64284|Hs108|chr2 ( 212) 324 79.9 1.1e-15 CCDS8673.1 RERG gene_id:85004|Hs108|chr12 ( 199) 318 78.6 2.6e-15 CCDS11703.1 RAB37 gene_id:326624|Hs108|chr17 ( 216) 317 78.4 3.2e-15 CCDS9321.1 RASL11A gene_id:387496|Hs108|chr13 ( 242) 309 76.7 1.2e-14 CCDS54161.1 RAB37 gene_id:326624|Hs108|chr17 ( 228) 306 76.0 1.8e-14 CCDS53603.1 RRAS2 gene_id:22800|Hs108|chr11 ( 169) 304 75.5 1.8e-14 CCDS82198.1 RAB37 gene_id:326624|Hs108|chr17 ( 196) 302 75.1 2.8e-14 CCDS32722.1 RAB37 gene_id:326624|Hs108|chr17 ( 223) 302 75.1 3.2e-14 CCDS58036.1 RIT1 gene_id:6016|Hs108|chr1 ( 183) 299 74.5 4.2e-14 CCDS8223.1 RAB6A gene_id:5870|Hs108|chr11 ( 208) 297 74.1 6.3e-14 CCDS12372.1 RAB3A gene_id:5864|Hs108|chr19 ( 220) 297 74.1 6.7e-14 CCDS8224.1 RAB6A gene_id:5870|Hs108|chr11 ( 208) 294 73.4 1e-13 CCDS62431.1 RIT2 gene_id:6014|Hs108|chr18 ( 153) 292 72.9 1e-13 CCDS46306.1 RAB1A gene_id:5861|Hs108|chr2 ( 205) 292 73.0 1.3e-13 CCDS10200.1 RASL12 gene_id:51285|Hs108|chr15 ( 266) 291 72.8 2e-13 CCDS31613.1 RAB1B gene_id:81876|Hs108|chr11 ( 201) 289 72.3 2.1e-13 CCDS6827.1 RAB14 gene_id:51552|Hs108|chr9 ( 215) 289 72.3 2.2e-13 CCDS12257.1 RAB3D gene_id:9545|Hs108|chr19 ( 219) 289 72.3 2.2e-13 CCDS3082.1 RAB6B gene_id:51560|Hs108|chr3 ( 208) 288 72.1 2.5e-13 CCDS3976.1 RAB3C gene_id:115827|Hs108|chr5 ( 227) 288 72.1 2.7e-13 CCDS41846.1 RAB35 gene_id:11021|Hs108|chr12 ( 201) 287 71.9 2.8e-13 CCDS8900.1 RAB5B gene_id:5869|Hs108|chr12 ( 215) 287 71.9 2.9e-13 CCDS560.1 RAB3B gene_id:5865|Hs108|chr1 ( 219) 284 71.2 4.7e-13 CCDS4962.1 RAB23 gene_id:51715|Hs108|chr6 ( 237) 284 71.3 5.1e-13 CCDS12201.1 RAB11B gene_id:9230|Hs108|chr19 ( 218) 280 70.4 8.6e-13 CCDS9570.1 RAB2B gene_id:84932|Hs108|chr14 ( 216) 278 69.9 1.1e-12 CCDS6175.1 RAB2A gene_id:5862|Hs108|chr8 ( 212) 277 69.7 1.3e-12 >>CCDS5927.1 RHEB gene_id:6009|Hs108|chr7 (184 aa) initn: 1162 init1: 1162 opt: 1162 Z-score: 1379.0 bits: 261.8 E(32554): 1.7e-70 Smith-Waterman score: 1162; 100.0% identity (100.0% similar) in 184 aa overlap (1-184:1-184) 10 20 30 40 50 60 pF1KB6 MPQSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 MPQSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 TAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 KDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFRRIILEAEKMDGAASQGKSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 KDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFRRIILEAEKMDGAASQGKSS 130 140 150 160 170 180 pF1KB6 CSVM :::: CCDS59 CSVM >>CCDS8778.1 RHEBL1 gene_id:121268|Hs108|chr12 (183 aa) initn: 618 init1: 618 opt: 657 Z-score: 786.6 bits: 152.2 E(32554): 1.7e-37 Smith-Waterman score: 657; 52.2% identity (81.5% similar) in 184 aa overlap (1-184:1-183) 10 20 30 40 50 60 pF1KB6 MPQSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVD :: . ::..::::: :::.::. :::::.: ..::::.:::..:..:.. .:.::.::: CCDS87 MPLVRYRKVVILGYRCVGKTSLAHQFVEGEFSEGYDPTVENTYSKIVTLGKDEFHLHLVD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNK :::::::::.: .. : ..::.:::::::..::.::. .. :: . ::...:..::::: CCDS87 TAGQDEYSILPYSFIIGVHGYVLVYSVTSLHSFQVIESLYQKLHEGHGKTRVPVVLVGNK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 KDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFRRIILEAEKMDGAASQGKSS :: :: .. ::: :::::.:.:.::::.::: . .: ..: : ..... .: . CCDS87 ADLSPEREVQAVEGKKLAESWGATFMESSARENQLTQGIFTKVIQEIARVENSYGQERR- 130 140 150 160 170 pF1KB6 CSVM : .: CCDS87 CHLM 180 >>CCDS3170.1 RAP2B gene_id:5912|Hs108|chr3 (183 aa) initn: 417 init1: 417 opt: 441 Z-score: 533.3 bits: 105.3 E(32554): 2.2e-23 Smith-Waterman score: 441; 41.3% identity (74.9% similar) in 179 aa overlap (5-181:2-176) 10 20 30 40 50 60 pF1KB6 MPQSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVD . :...:: .::::.::.::: :.:...::::::. . : : :... :...: CCDS31 MREYKVVVLGSGGVGKSALTVQFVTGSFIEKYDPTIEDFYRKEIEVDSSPSVLEILD 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 TAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNK ::: .... . . : . .:.:::::... .::. :: .. ... . ..:..::::: CCDS31 TAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYERVPMILVGNK 60 70 80 90 100 110 130 140 150 160 170 pF1KB6 KDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVD-VFRRIILEAEKMDGAAS-QGK ::. :: .:: ::::::: :. :.:.::: :...:: .: .:. ..:. ::. .: CCDS31 VDLEGEREVSYGEGKALAEEWSCPFMETSAK-NKASVDELFAEIV---RQMNYAAQPNGD 120 130 140 150 160 170 180 pF1KB6 SSCSVM .: CCDS31 EGCCSACVIL 180 >>CCDS8984.1 RAP1B gene_id:5908|Hs108|chr12 (184 aa) initn: 399 init1: 380 opt: 441 Z-score: 533.2 bits: 105.3 E(32554): 2.2e-23 Smith-Waterman score: 441; 38.0% identity (74.5% similar) in 184 aa overlap (5-184:2-184) 10 20 30 40 50 60 pF1KB6 MPQSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVD . :...:: .::::.::.:::.: ::..::::::... : . :..:. :...: CCDS89 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILD 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 TAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNK ::: .... . . : . .:. ::::.:. ..:. .. .. ..: . ..:..::::: CCDS89 TAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNK 60 70 80 90 100 110 130 140 150 160 170 pF1KB6 KDLHMERVISYEEGKALAESWNA-AFLESSAKENQTAVDVFRRIILEAEK---MDGAASQ ::. :::.. :.:. ::..:: :::::::: . .. ..: .. . .. . : : . CCDS89 CDLEDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARK 120 130 140 150 160 170 180 pF1KB6 GKSSCSVM ::::... CCDS89 -KSSCQLL 180 >>CCDS9485.1 RAP2A gene_id:5911|Hs108|chr13 (183 aa) initn: 408 init1: 408 opt: 430 Z-score: 520.4 bits: 102.9 E(32554): 1.2e-22 Smith-Waterman score: 430; 40.3% identity (72.9% similar) in 181 aa overlap (5-182:2-178) 10 20 30 40 50 60 pF1KB6 MPQSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVD . :...:: .::::.::.::: : :...::::::. . : : :... :...: CCDS94 MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILD 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 TAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNK ::: .... . . : . .:.:::::... .::. :: .. ... . ..:..::::: CCDS94 TAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYEKVPVILVGNK 60 70 80 90 100 110 130 140 150 160 170 pF1KB6 KDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVD-VFRRIILEAEKMDGAASQGKS ::. :: .: ::.:::: :. :.:.::: ..: :: .: .:. ..:. ::. :. CCDS94 VDLESEREVSSSEGRALAEEWGCPFMETSAK-SKTMVDELFAEIV---RQMNYAAQPDKD 120 130 140 150 160 170 180 pF1KB6 S--CSVM . :: CCDS94 DPCCSACNIQ 180 >>CCDS840.1 RAP1A gene_id:5906|Hs108|chr1 (184 aa) initn: 395 init1: 358 opt: 426 Z-score: 515.6 bits: 102.0 E(32554): 2.1e-22 Smith-Waterman score: 426; 36.6% identity (73.2% similar) in 183 aa overlap (5-184:2-184) 10 20 30 40 50 60 pF1KB6 MPQSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVD . :...:: .::::.::.:::.: ::..::::::... : . :. :. :...: CCDS84 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILD 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 TAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNK ::: .... . . : . .:. ::::.:. ..:. .. .. ..: . ..:..::::: CCDS84 TAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNK 60 70 80 90 100 110 130 140 150 160 170 pF1KB6 KDLHMERVISYEEGKALAESW-NAAFLESSAKENQTAVDVFRRIILEAEKMDGAASQG-- ::. :::.. :.:. ::..: : :::::::: . .. ..: .. . .. . .. CCDS84 CDLEDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPK 120 130 140 150 160 170 180 pF1KB6 KSSCSVM :.:: .. CCDS84 KKSCLLL 180 >>CCDS14632.1 RAP2C gene_id:57826|Hs108|chrX (183 aa) initn: 393 init1: 393 opt: 409 Z-score: 495.7 bits: 98.3 E(32554): 2.7e-21 Smith-Waterman score: 409; 35.9% identity (70.7% similar) in 181 aa overlap (5-183:2-182) 10 20 30 40 50 60 pF1KB6 MPQSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVD . :...:: .::::.::.::: : :...::::::. . : : :... :...: CCDS14 MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILD 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 TAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNK ::: .... . . : . .:.:::::... .::. :: .. ... . ..:..::::: CCDS14 TAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIVRVKRYEKVPLILVGNK 60 70 80 90 100 110 130 140 150 160 170 pF1KB6 KDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFRRII--LEAEKMDGAASQGK ::. :: . ::.:::. :. :.:.::: .. . ..: .:. .. .. .: CCDS14 VDLEPEREVMSSEGRALAQEWGCPFMETSAKSKSMVDELFAEIVRQMNYSSLPEKQDQCC 120 130 140 150 160 170 180 pF1KB6 SSCSVM ..: : CCDS14 TTCVVQ 180 >>CCDS6687.1 DIRAS2 gene_id:54769|Hs108|chr9 (199 aa) initn: 386 init1: 244 opt: 404 Z-score: 489.3 bits: 97.3 E(32554): 6.2e-21 Smith-Waterman score: 404; 39.7% identity (74.5% similar) in 184 aa overlap (1-180:1-183) 10 20 30 40 50 pF1KB6 MP-QSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLV :: ::.. ..:..: .::::::...::.: : .:: ::.:.:. ..:. . . ::.. CCDS66 MPEQSNDYRVAVFGAGGVGKSSLVLRFVKGTFRESYIPTVEDTYRQVISCDKSICTLQIT 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 DTAGQDEYSIFPQTYSIDI-NGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQ-IPIMLV ::.:. .. . : ::. ...:::::.:: .:.: .: :. .. .. : :. :::::: CCDS66 DTTGSHQFPAM-QRLSISKGHAFILVYSITSRQSLEELKPIYEQICEIKGDVESIPIMLV 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 GNKKDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFRRII-LEAEKMDGAASQ ::: : : .. :..:::..:. ::.:.::: :... ..:.... :: .. . . CCDS66 GNKCDESPSREVQSSEAEALARTWKCAFMETSAKLNHNVKELFQELLNLEKRRTVSLQID 120 130 140 150 160 170 180 pF1KB6 GKSSCSVM ::.: CCDS66 GKKSKQQKRKEKLKGKCVIM 180 190 >>CCDS8702.1 KRAS gene_id:3845|Hs108|chr12 (188 aa) initn: 330 init1: 290 opt: 393 Z-score: 476.8 bits: 94.9 E(32554): 3.1e-20 Smith-Waterman score: 393; 36.8% identity (70.8% similar) in 185 aa overlap (8-184:5-188) 10 20 30 40 50 60 pF1KB6 MPQSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVD :....: .::::.::::.....::: ::::::... : ....:. :...: CCDS87 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILD 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 TAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNK ::::.::: . . : .:.. :..... :::: :. . .. . . ..:..::::: CCDS87 TAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNK 60 70 80 90 100 110 130 140 150 160 170 pF1KB6 KDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFRRIILEA----EKM--DGAA :: :... .... ::.:.. :.:.::: : . :.: .. : ::: :: CCDS87 CDLP-SRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHKEKMSKDGKK 120 130 140 150 160 170 180 pF1KB6 SQGKSS--CSVM .. ::. : .: CCDS87 KKKKSKTKCVIM 180 >>CCDS12774.1 RRAS gene_id:6237|Hs108|chr19 (218 aa) initn: 344 init1: 344 opt: 385 Z-score: 466.3 bits: 93.2 E(32554): 1.2e-19 Smith-Waterman score: 385; 34.5% identity (76.8% similar) in 168 aa overlap (2-169:25-192) 10 20 30 pF1KB6 MPQSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDP : :...:....: .::::.:::::... ::..::: CCDS12 MSSGAASGTGRGRPRGGGPGPGDPPPSETHKLVVVGGGGVGKSALTIQFIQSYFVSDYDP 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB6 TIENTFTKLITVNGQEYHLQLVDTAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIK :::...::. .:.: .:...:::::.:.. . . : .:..::..... .::. . CCDS12 TIEDSYTKICSVDGIPARLDILDTAGQEEFGAMREQYMRAGHGFLLVFAINDRQSFNEVG 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB6 VIHGKLLDMVGKVQIPIMLVGNKKDLHMERVISYEEGKALAESWNAAFLESSAKENQTAV . ..: . . ..:..::::: ::. .: . :..:.. : ..:..:.::: .. CCDS12 KLFTQILRVKDRDDFPVVLVGNKADLESQRQVPRSEASAFGASHHVAYFEASAKLRLNVD 130 140 150 160 170 180 160 170 180 pF1KB6 DVFRRIILEAEKMDGAASQGKSSCSVM ..:.... ..: CCDS12 EAFEQLVRAVRKYQEQELPPSPPSAPRKKGGGCPCVLL 190 200 210 184 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 13:52:20 2016 done: Fri Nov 4 13:52:21 2016 Total Scan time: 1.670 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]