FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6904, 223 aa 1>>>pF1KB6904 223 - 223 aa - 223 aa Library: /omim/omim.rfq.tfa 64369986 residues in 92320 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.3929+/-0.000326; mu= 19.0676+/- 0.020 mean_var=62.8771+/-12.658, 0's: 0 Z-trim(116.2): 22 B-trim: 283 in 1/48 Lambda= 0.161744 statistics sampled from 28354 (28376) to 28354 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.683), E-opt: 0.2 (0.307), width: 16 Scan time: 2.980 The best scores are: opt bits E(92320) NP_005205 (OMIM: 123890,140300,152700,601388,60975 ( 223) 1501 358.4 5.9e-99 NP_001032720 (OMIM: 123890,140300,152700,601388,60 ( 174) 1021 246.3 2.6e-65 NP_006130 (OMIM: 186760) T-cell-specific surface g ( 220) 280 73.5 3.4e-13 XP_011510496 (OMIM: 186760) T-cell-specific surfac ( 234) 275 72.3 8.1e-13 NP_001138939 (OMIM: 609148,611550) natural cytotox ( 190) 151 43.3 0.00036 NP_001138938 (OMIM: 609148,611550) natural cytotox ( 177) 149 42.8 0.00047 XP_011510499 (OMIM: 186760) T-cell-specific surfac ( 136) 129 38.0 0.0099 >>NP_005205 (OMIM: 123890,140300,152700,601388,609755,61 (223 aa) initn: 1501 init1: 1501 opt: 1501 Z-score: 1898.1 bits: 358.4 E(92320): 5.9e-99 Smith-Waterman score: 1501; 99.6% identity (100.0% similar) in 223 aa overlap (1-223:1-223) 10 20 30 40 50 60 pF1KB6 MACLGFQRHKAQLNLAARTWPCTLLFFLLFIPVFCKAMHVAQPAVVLASSRGIASFVCEY ::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::: NP_005 MACLGFQRHKAQLNLATRTWPCTLLFFLLFIPVFCKAMHVAQPAVVLASSRGIASFVCEY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 ASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 AMDTGLYICKVELMYPPPYYLGIGNGTQIYVIDPEPCPDSDFLLWILAAVSSGLFFYSFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 AMDTGLYICKVELMYPPPYYLGIGNGTQIYVIDPEPCPDSDFLLWILAAVSSGLFFYSFL 130 140 150 160 170 180 190 200 210 220 pF1KB6 LTAVSLSKMLKKRSPLTTGVYVKMPPTEPECEKQFQPYFIPIN ::::::::::::::::::::::::::::::::::::::::::: NP_005 LTAVSLSKMLKKRSPLTTGVYVKMPPTEPECEKQFQPYFIPIN 190 200 210 220 >>NP_001032720 (OMIM: 123890,140300,152700,601388,609755 (174 aa) initn: 1021 init1: 1021 opt: 1021 Z-score: 1294.2 bits: 246.3 E(92320): 2.6e-65 Smith-Waterman score: 1021; 96.8% identity (97.5% similar) in 158 aa overlap (1-158:1-158) 10 20 30 40 50 60 pF1KB6 MACLGFQRHKAQLNLAARTWPCTLLFFLLFIPVFCKAMHVAQPAVVLASSRGIASFVCEY ::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::: NP_001 MACLGFQRHKAQLNLATRTWPCTLLFFLLFIPVFCKAMHVAQPAVVLASSRGIASFVCEY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 ASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQGLR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 AMDTGLYICKVELMYPPPYYLGIGNGTQIYVIDPEPCPDSDFLLWILAAVSSGLFFYSFL :::::::::::::::::::::::::::::::: : : NP_001 AMDTGLYICKVELMYPPPYYLGIGNGTQIYVIAKEKKPSYNRGLCENAPNRARM 130 140 150 160 170 190 200 210 220 pF1KB6 LTAVSLSKMLKKRSPLTTGVYVKMPPTEPECEKQFQPYFIPIN >>NP_006130 (OMIM: 186760) T-cell-specific surface glyco (220 aa) initn: 150 init1: 128 opt: 280 Z-score: 358.4 bits: 73.5 E(92320): 3.4e-13 Smith-Waterman score: 280; 31.0% identity (61.9% similar) in 210 aa overlap (24-221:5-212) 10 20 30 40 50 pF1KB6 MACLGFQRHKAQLNLAARTWPCTLLFFLLF--IPVFCKAMHVAQPAVVLASSRGIASFVC :: . :: : : . . : : ...: . .. .. : NP_006 MLRLLLALNLFPSIQVTGNKILVKQSPMLVAYDNAV-NLSC 10 20 30 40 60 70 80 90 100 110 pF1KB6 EYASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDS--ICTGTSSGNQVNLTI .:. . : :... . :: : :::.. ....: . . : : ....:.. . NP_006 KYSYNLFSREFRASLHKGLDSAV-EVCVVYGNYSQQLQVYSKTGFNCDGKLGNESVTFYL 50 60 70 80 90 120 130 140 150 160 170 pF1KB6 QGLRAMDTGLYICKVELMYPPPYYLG-IGNGTQIYVIDPEPCPDSDFL-----LWILAAV :.: . .: .:.::.:.:::::: . .::: :.: . ::. : .:.:..: NP_006 QNLYVNQTDIYFCKIEVMYPPPYLDNEKSNGTIIHVKGKHLCPSPLFPGPSKPFWVLVVV 100 110 120 130 140 150 180 190 200 210 220 pF1KB6 SSGLFFYSFLLTAVSLSKMLK-KRSPLTTGVYVKMPPTEP-ECEKQFQPYFIPIN .. : ::.:.:.. . .. ::: : . :..: : .: .:..::: : NP_006 GGVLACYSLLVTVAFIIFWVRSKRSRLLHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAYR 160 170 180 190 200 210 NP_006 S 220 >>XP_011510496 (OMIM: 186760) T-cell-specific surface gl (234 aa) initn: 150 init1: 128 opt: 275 Z-score: 351.7 bits: 72.3 E(92320): 8.1e-13 Smith-Waterman score: 275; 30.7% identity (63.0% similar) in 192 aa overlap (40-221:37-226) 10 20 30 40 50 60 pF1KB6 KAQLNLAARTWPCTLLFFLLFIPVFCKAMHVAQPAVVLASSRGIASFVCEYASPGKATEV : : ...: . .. .. :.:. . : XP_011 ALIMCPKGMVAVVVAVDDGDSQALAGNKILVKQSPMLVAYDNAV-NLSCKYSYNLFSREF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 RVTVLRQADSQVTEVCAATYMMGNELTFLDDS--ICTGTSSGNQVNLTIQGLRAMDTGLY :... . :: : :::.. ....: . . : : ....:.. .:.: . .: .: XP_011 RASLHKGLDSAV-EVCVVYGNYSQQLQVYSKTGFNCDGKLGNESVTFYLQNLYVNQTDIY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 ICKVELMYPPPYYLG-IGNGTQIYVIDPEPCPDSDFL-----LWILAAVSSGLFFYSFLL .::.:.:::::: . .::: :.: . ::. : .:.:..:.. : ::.:. XP_011 FCKIEVMYPPPYLDNEKSNGTIIHVKGKHLCPSPLFPGPSKPFWVLVVVGGVLACYSLLV 130 140 150 160 170 180 190 200 210 220 pF1KB6 TAVSLSKMLK-KRSPLTTGVYVKMPPTEP-ECEKQFQPYFIPIN :.. . .. ::: : . :..: : .: .:..::: : XP_011 TVAFIIFWVRSKRSRLLHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAYRS 190 200 210 220 230 >>NP_001138939 (OMIM: 609148,611550) natural cytotoxicit (190 aa) initn: 56 init1: 35 opt: 151 Z-score: 196.5 bits: 43.3 E(92320): 0.00036 Smith-Waterman score: 151; 26.5% identity (54.6% similar) in 196 aa overlap (24-211:6-189) 10 20 30 40 50 pF1KB6 MACLGFQRHKAQLNLAARTWPCTLLFFLLFIPVFCKAMHVAQPAVVLASSRGIASFV-CE ::.... : : :. :.:: . . .: ..:. : NP_001 MAWMLLLILIMVHPGSC-ALWVSQPPEI-RTLEGSSAFLPCS 10 20 30 40 60 70 80 90 100 110 pF1KB6 Y-ASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQG . :: :. . :: .:. :: .: . ..:. : .: .:..: :. NP_001 FNASQGRLAIGSVTWFRDEVVPGKEVRNGTPEFRGRLAPLASSRFL---HDHQAELHIRD 50 60 70 80 90 120 130 140 150 160 170 pF1KB6 LRAMDTGLYICKVELMYPPPYYLGIGNGTQIYVIDPEPCPDSDFLLWILAAVSSGLFFYS .:. :...:.:.::.. .: ::::.. : .: . .: . : :.. : NP_001 VRGHDASIYVCRVEVL---GLGVGTGNGTRLVVEKEHPQLGAGTVLLLRA----GFYAVS 100 110 120 130 140 150 180 190 200 210 220 pF1KB6 FLLTAVSLSKMLKKRSPLTTGVYVKMP--PT----EPECEKQFQPYFIPIN :: .::. . . . . :.. . : ::.: NP_001 FLSVAVGSTVYYQGKCHCHMGTHCHSSDGPRGVIPEPRCP 160 170 180 190 >>NP_001138938 (OMIM: 609148,611550) natural cytotoxicit (177 aa) initn: 56 init1: 35 opt: 149 Z-score: 194.4 bits: 42.8 E(92320): 0.00047 Smith-Waterman score: 149; 28.8% identity (57.1% similar) in 163 aa overlap (24-184:6-156) 10 20 30 40 50 pF1KB6 MACLGFQRHKAQLNLAARTWPCTLLFFLLFIPVFCKAMHVAQPAVVLASSRGIASFV-CE ::.... : : :. :.:: . . .: ..:. : NP_001 MAWMLLLILIMVHPGSC-ALWVSQPPEI-RTLEGSSAFLPCS 10 20 30 40 60 70 80 90 100 110 pF1KB6 Y-ASPGKATEVRVTVLRQADSQVTEVCAATYMMGNELTFLDDSICTGTSSGNQVNLTIQG . :: :. . :: .:. :: .: . ..:. : .: .:..: :. NP_001 FNASQGRLAIGSVTWFRDEVVPGKEVRNGTPEFRGRLAPLASSRFL---HDHQAELHIRD 50 60 70 80 90 120 130 140 150 160 170 pF1KB6 LRAMDTGLYICKVELMYPPPYYLGIGNGTQIYVIDPEPCPDSDFLLWILAAVSSGLFFYS .:. :...:.:.::.. .: ::::.. : .: . .: . : :.. : NP_001 VRGHDASIYVCRVEVL---GLGVGTGNGTRLVVEKEHPQLGAGTVLLLRA----GFYAVS 100 110 120 130 140 150 180 190 200 210 220 pF1KB6 FLLTAVSLSKMLKKRSPLTTGVYVKMPPTEPECEKQFQPYFIPIN :: .:: NP_001 FLSVAVGSTVYYQGKYAKSTLSGFPQL 160 170 >>XP_011510499 (OMIM: 186760) T-cell-specific surface gl (136 aa) initn: 65 init1: 43 opt: 129 Z-score: 170.6 bits: 38.0 E(92320): 0.0099 Smith-Waterman score: 129; 34.5% identity (61.9% similar) in 84 aa overlap (145-221:45-128) 120 130 140 150 160 pF1KB6 TIQGLRAMDTGLYICKVELMYPPPYYLGIGNGTQIYVIDPEPCPDSDFL-----LWILAA ::: :.: . ::. : .:.:.. XP_011 QVTGNKILVKQSPMLVAYDNAVNLSYNEKSNGTIIHVKGKHLCPSPLFPGPSKPFWVLVV 20 30 40 50 60 70 170 180 190 200 210 220 pF1KB6 VSSGLFFYSFLLTAVSLSKMLK-KRSPLTTGVYVKMPPTEP-ECEKQFQPYFIPIN :.. : ::.:.:.. . .. ::: : . :..: : .: .:..::: : XP_011 VGGVLACYSLLVTVAFIIFWVRSKRSRLLHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAY 80 90 100 110 120 130 XP_011 RS 223 residues in 1 query sequences 64369986 residues in 92320 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Oct 24 21:38:19 2019 done: Thu Oct 24 21:38:19 2019 Total Scan time: 2.980 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]