FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6905, 204 aa 1>>>pF1KB6905 204 - 204 aa - 204 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.7100+/-0.000324; mu= 17.9341+/- 0.021 mean_var=85.8657+/-16.876, 0's: 0 Z-trim(118.2): 413 B-trim: 626 in 1/51 Lambda= 0.138409 statistics sampled from 30486 (30962) to 30486 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.745), E-opt: 0.2 (0.363), width: 16 Scan time: 5.400 The best scores are: opt bits E(85289) NP_036382 (OMIM: 600098) ras-related protein R-Ras ( 204) 1366 281.8 5.2e-76 XP_016872852 (OMIM: 600098) PREDICTED: ras-related ( 182) 1136 235.8 3.2e-62 NP_001170785 (OMIM: 600098) ras-related protein R- ( 169) 1128 234.2 9.3e-62 NP_006261 (OMIM: 165090) ras-related protein R-Ras ( 218) 880 184.8 8.8e-47 NP_001170786 (OMIM: 600098) ras-related protein R- ( 127) 856 179.7 1.7e-45 NP_001096139 (OMIM: 600098) ras-related protein R- ( 127) 856 179.7 1.7e-45 XP_005247285 (OMIM: 608435) PREDICTED: ras-related ( 208) 729 154.6 1e-37 NP_001078518 (OMIM: 608435) ras-related protein M- ( 208) 729 154.6 1e-37 XP_016861376 (OMIM: 608435) PREDICTED: ras-related ( 208) 729 154.6 1e-37 NP_001239019 (OMIM: 608435) ras-related protein M- ( 208) 729 154.6 1e-37 NP_036351 (OMIM: 608435) ras-related protein M-Ras ( 208) 729 154.6 1e-37 XP_011518955 (OMIM: 109800,114480,137215,163200,19 ( 188) 677 144.2 1.3e-34 NP_004976 (OMIM: 109800,114480,137215,163200,19007 ( 188) 677 144.2 1.3e-34 NP_001123914 (OMIM: 109800,137550,162900,163200,18 ( 189) 672 143.2 2.6e-34 NP_005334 (OMIM: 109800,137550,162900,163200,18847 ( 189) 672 143.2 2.6e-34 XP_006719132 (OMIM: 109800,114480,137215,163200,19 ( 189) 653 139.4 3.5e-33 NP_203524 (OMIM: 109800,114480,137215,163200,19007 ( 189) 653 139.4 3.5e-33 XP_016874782 (OMIM: 109800,114480,137215,163200,19 ( 227) 653 139.5 4e-33 NP_002515 (OMIM: 114500,137550,162900,163200,16479 ( 189) 639 136.6 2.5e-32 NP_008843 (OMIM: 609591,615355) GTP-binding protei ( 219) 631 135.1 8.2e-32 NP_001243750 (OMIM: 609591,615355) GTP-binding pro ( 236) 631 135.1 8.6e-32 NP_002921 (OMIM: 609592) GTP-binding protein Rit2 ( 217) 619 132.7 4.3e-31 XP_005247286 (OMIM: 608435) PREDICTED: ras-related ( 170) 614 131.6 7.3e-31 NP_001010942 (OMIM: 179530) ras-related protein Ra ( 184) 614 131.6 7.7e-31 NP_056461 (OMIM: 179530) ras-related protein Rap-1 ( 184) 614 131.6 7.7e-31 NP_001010935 (OMIM: 179520) ras-related protein Ra ( 184) 607 130.2 2e-30 NP_001278825 (OMIM: 179520) ras-related protein Ra ( 184) 607 130.2 2e-30 XP_016857451 (OMIM: 179520) PREDICTED: ras-related ( 184) 607 130.2 2e-30 XP_016857452 (OMIM: 179520) PREDICTED: ras-related ( 184) 607 130.2 2e-30 XP_016857453 (OMIM: 179520) PREDICTED: ras-related ( 184) 607 130.2 2e-30 NP_002875 (OMIM: 179520) ras-related protein Rap-1 ( 184) 607 130.2 2e-30 NP_789765 (OMIM: 109800,137550,162900,163200,18847 ( 170) 601 129.0 4.4e-30 NP_002872 (OMIM: 179551) ras-related protein Ral-B ( 206) 593 127.5 1.5e-29 XP_005263784 (OMIM: 179551) PREDICTED: ras-related ( 206) 593 127.5 1.5e-29 XP_016860111 (OMIM: 179551) PREDICTED: ras-related ( 206) 593 127.5 1.5e-29 XP_005263785 (OMIM: 179551) PREDICTED: ras-related ( 206) 593 127.5 1.5e-29 XP_005263786 (OMIM: 179551) PREDICTED: ras-related ( 206) 593 127.5 1.5e-29 XP_016860110 (OMIM: 179551) PREDICTED: ras-related ( 228) 593 127.5 1.6e-29 XP_005263781 (OMIM: 179551) PREDICTED: ras-related ( 228) 593 127.5 1.6e-29 XP_011509875 (OMIM: 179551) PREDICTED: ras-related ( 229) 593 127.5 1.6e-29 XP_006715825 (OMIM: 179550) PREDICTED: ras-related ( 206) 588 126.5 3e-29 XP_011513768 (OMIM: 179550) PREDICTED: ras-related ( 206) 588 126.5 3e-29 NP_005393 (OMIM: 179550) ras-related protein Ral-A ( 206) 588 126.5 3e-29 XP_016857450 (OMIM: 179520) PREDICTED: ras-related ( 195) 566 122.1 6.1e-28 XP_016857449 (OMIM: 179520) PREDICTED: ras-related ( 195) 566 122.1 6.1e-28 NP_001243749 (OMIM: 609591,615355) GTP-binding pro ( 183) 554 119.6 3.1e-27 NP_002877 (OMIM: 179541) ras-related protein Rap-2 ( 183) 539 116.6 2.5e-26 NP_066361 (OMIM: 179540) ras-related protein Rap-2 ( 183) 534 115.6 4.9e-26 NP_116307 (OMIM: 612664) ras-related and estrogen- ( 199) 506 110.1 2.5e-24 NP_001259006 (OMIM: 609592) GTP-binding protein Ri ( 153) 493 107.4 1.3e-23 >>NP_036382 (OMIM: 600098) ras-related protein R-Ras2 is (204 aa) initn: 1366 init1: 1366 opt: 1366 Z-score: 1485.7 bits: 281.8 E(85289): 5.2e-76 Smith-Waterman score: 1366; 100.0% identity (100.0% similar) in 204 aa overlap (1-204:1-204) 10 20 30 40 50 60 pF1KB6 MAAAGWRDGSGQEKYRLVVVGGGGVGKSALTIQFIQSYFVTDYDPTIEDSYTKQCVIDDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 MAAAGWRDGSGQEKYRLVVVGGGGVGKSALTIQFIQSYFVTDYDPTIEDSYTKQCVIDDR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 AARLDILDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYKFQRQILRVKDRDEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 AARLDILDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYKFQRQILRVKDRDEF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 PMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVDQAFHELVRVIRKFQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 PMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVDQAFHELVRVIRKFQE 130 140 150 160 170 180 190 200 pF1KB6 QECPPSPEPTRKEKDKKGCHCVIF :::::::::::::::::::::::: NP_036 QECPPSPEPTRKEKDKKGCHCVIF 190 200 >>XP_016872852 (OMIM: 600098) PREDICTED: ras-related pro (182 aa) initn: 1134 init1: 1134 opt: 1136 Z-score: 1238.0 bits: 235.8 E(85289): 3.2e-62 Smith-Waterman score: 1136; 95.0% identity (96.7% similar) in 181 aa overlap (24-204:5-182) 10 20 30 40 50 60 pF1KB6 MAAAGWRDGSGQEKYRLVVVGGGGVGKSALTIQFIQSYFVTDYDPTIEDSYTKQCVIDDR : :.. : :.:::::::::::::::::::::::: XP_016 MTKLGSGEARL---HIRSYFVTDYDPTIEDSYTKQCVIDDR 10 20 30 70 80 90 100 110 120 pF1KB6 AARLDILDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYKFQRQILRVKDRDEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AARLDILDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYKFQRQILRVKDRDEF 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB6 PMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVDQAFHELVRVIRKFQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVDQAFHELVRVIRKFQE 100 110 120 130 140 150 190 200 pF1KB6 QECPPSPEPTRKEKDKKGCHCVIF :::::::::::::::::::::::: XP_016 QECPPSPEPTRKEKDKKGCHCVIF 160 170 180 >>NP_001170785 (OMIM: 600098) ras-related protein R-Ras2 (169 aa) initn: 1128 init1: 1128 opt: 1128 Z-score: 1229.8 bits: 234.2 E(85289): 9.3e-62 Smith-Waterman score: 1128; 100.0% identity (100.0% similar) in 168 aa overlap (37-204:2-169) 10 20 30 40 50 60 pF1KB6 RDGSGQEKYRLVVVGGGGVGKSALTIQFIQSYFVTDYDPTIEDSYTKQCVIDDRAARLDI :::::::::::::::::::::::::::::: NP_001 MSYFVTDYDPTIEDSYTKQCVIDDRAARLDI 10 20 30 70 80 90 100 110 120 pF1KB6 LDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYKFQRQILRVKDRDEFPMILIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYKFQRQILRVKDRDEFPMILIG 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB6 NKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVDQAFHELVRVIRKFQEQECPPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVDQAFHELVRVIRKFQEQECPPS 100 110 120 130 140 150 190 200 pF1KB6 PEPTRKEKDKKGCHCVIF :::::::::::::::::: NP_001 PEPTRKEKDKKGCHCVIF 160 >>NP_006261 (OMIM: 165090) ras-related protein R-Ras [Ho (218 aa) initn: 864 init1: 838 opt: 880 Z-score: 960.8 bits: 184.8 E(85289): 8.8e-47 Smith-Waterman score: 880; 66.0% identity (85.5% similar) in 200 aa overlap (5-204:20-218) 10 20 30 40 pF1KB6 MAAAGWRDGSGQEKYRLVVVGGGGVGKSALTIQFIQSYFVTDYDP : : .: ..::::::::::::::::::::::::.:::: NP_006 MSSGAASGTGRGRPRGGGPGPGDPPPSETHKLVVVGGGGVGKSALTIQFIQSYFVSDYDP 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB6 TIEDSYTKQCVIDDRAARLDILDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIY :::::::: : .: :::::::::::::::::::::::.:.::::::...:: ::.:. NP_006 TIEDSYTKICSVDGIPARLDILDTAGQEEFGAMREQYMRAGHGFLLVFAINDRQSFNEVG 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB6 KFQRQILRVKDRDEFPMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVD :. :::::::::.::..:.::::::. :::: . :.. .. . .:.:.:::::.:.::: NP_006 KLFTQILRVKDRDDFPVVLVGNKADLESQRQVPRSEASAFGASHHVAYFEASAKLRLNVD 130 140 150 160 170 180 170 180 190 200 pF1KB6 QAFHELVRVIRKFQEQECPPSPEPTRKEKDKKGCHCVIF .::..:::..::.:::: :::: :. .: :: ::.. NP_006 EAFEQLVRAVRKYQEQELPPSP-PSAPRKKGGGCPCVLL 190 200 210 >>NP_001170786 (OMIM: 600098) ras-related protein R-Ras2 (127 aa) initn: 856 init1: 856 opt: 856 Z-score: 937.7 bits: 179.7 E(85289): 1.7e-45 Smith-Waterman score: 856; 100.0% identity (100.0% similar) in 127 aa overlap (78-204:1-127) 50 60 70 80 90 100 pF1KB6 EDSYTKQCVIDDRAARLDILDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYKF :::::::::::::::::::::::::::::: NP_001 MREQYMRTGEGFLLVFSVTDRGSFEEIYKF 10 20 30 110 120 130 140 150 160 pF1KB6 QRQILRVKDRDEFPMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVDQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QRQILRVKDRDEFPMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVDQA 40 50 60 70 80 90 170 180 190 200 pF1KB6 FHELVRVIRKFQEQECPPSPEPTRKEKDKKGCHCVIF ::::::::::::::::::::::::::::::::::::: NP_001 FHELVRVIRKFQEQECPPSPEPTRKEKDKKGCHCVIF 100 110 120 >>NP_001096139 (OMIM: 600098) ras-related protein R-Ras2 (127 aa) initn: 856 init1: 856 opt: 856 Z-score: 937.7 bits: 179.7 E(85289): 1.7e-45 Smith-Waterman score: 856; 100.0% identity (100.0% similar) in 127 aa overlap (78-204:1-127) 50 60 70 80 90 100 pF1KB6 EDSYTKQCVIDDRAARLDILDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYKF :::::::::::::::::::::::::::::: NP_001 MREQYMRTGEGFLLVFSVTDRGSFEEIYKF 10 20 30 110 120 130 140 150 160 pF1KB6 QRQILRVKDRDEFPMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVDQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QRQILRVKDRDEFPMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVDQA 40 50 60 70 80 90 170 180 190 200 pF1KB6 FHELVRVIRKFQEQECPPSPEPTRKEKDKKGCHCVIF ::::::::::::::::::::::::::::::::::::: NP_001 FHELVRVIRKFQEQECPPSPEPTRKEKDKKGCHCVIF 100 110 120 >>XP_005247285 (OMIM: 608435) PREDICTED: ras-related pro (208 aa) initn: 713 init1: 644 opt: 729 Z-score: 798.1 bits: 154.6 E(85289): 1e-37 Smith-Waterman score: 729; 58.5% identity (82.1% similar) in 195 aa overlap (15-204:14-208) 10 20 30 40 50 60 pF1KB6 MAAAGWRDGSGQEKYRLVVVGGGGVGKSALTIQFIQSYFVTDYDPTIEDSYTKQCVIDDR :.::::: ::::::::::::.:. :: :::::::::: :. ::.. XP_005 MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQ 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 AARLDILDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYKFQRQILRVKDRDEF : ::.:::::::::.::::::::::.:::.:.::::..:::.. .:.. :::::::. : XP_005 WAILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESF 60 70 80 90 100 110 130 140 150 160 170 pF1KB6 PMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAK-IRMNVDQAFHELVRVIRKFQ ::::..::.:: : :..:.:.:...: . .. :.:.::: .:::.:::.::::::. XP_005 PMILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDPPLNVDKAFHDLVRVIRQQI 120 130 140 150 160 170 180 190 200 pF1KB6 EQECPPSPEPTRKEKDKK-GCH---CVIF .. . . :. . :. : : :::. XP_005 PEKSQKKKKKTKWRGDRATGTHKLQCVIL 180 190 200 >>NP_001078518 (OMIM: 608435) ras-related protein M-Ras (208 aa) initn: 713 init1: 644 opt: 729 Z-score: 798.1 bits: 154.6 E(85289): 1e-37 Smith-Waterman score: 729; 58.5% identity (82.1% similar) in 195 aa overlap (15-204:14-208) 10 20 30 40 50 60 pF1KB6 MAAAGWRDGSGQEKYRLVVVGGGGVGKSALTIQFIQSYFVTDYDPTIEDSYTKQCVIDDR :.::::: ::::::::::::.:. :: :::::::::: :. ::.. NP_001 MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQ 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 AARLDILDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYKFQRQILRVKDRDEF : ::.:::::::::.::::::::::.:::.:.::::..:::.. .:.. :::::::. : NP_001 WAILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESF 60 70 80 90 100 110 130 140 150 160 170 pF1KB6 PMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAK-IRMNVDQAFHELVRVIRKFQ ::::..::.:: : :..:.:.:...: . .. :.:.::: .:::.:::.::::::. NP_001 PMILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDPPLNVDKAFHDLVRVIRQQI 120 130 140 150 160 170 180 190 200 pF1KB6 EQECPPSPEPTRKEKDKK-GCH---CVIF .. . . :. . :. : : :::. NP_001 PEKSQKKKKKTKWRGDRATGTHKLQCVIL 180 190 200 >>XP_016861376 (OMIM: 608435) PREDICTED: ras-related pro (208 aa) initn: 713 init1: 644 opt: 729 Z-score: 798.1 bits: 154.6 E(85289): 1e-37 Smith-Waterman score: 729; 58.5% identity (82.1% similar) in 195 aa overlap (15-204:14-208) 10 20 30 40 50 60 pF1KB6 MAAAGWRDGSGQEKYRLVVVGGGGVGKSALTIQFIQSYFVTDYDPTIEDSYTKQCVIDDR :.::::: ::::::::::::.:. :: :::::::::: :. ::.. XP_016 MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQ 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 AARLDILDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYKFQRQILRVKDRDEF : ::.:::::::::.::::::::::.:::.:.::::..:::.. .:.. :::::::. : XP_016 WAILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESF 60 70 80 90 100 110 130 140 150 160 170 pF1KB6 PMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAK-IRMNVDQAFHELVRVIRKFQ ::::..::.:: : :..:.:.:...: . .. :.:.::: .:::.:::.::::::. XP_016 PMILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDPPLNVDKAFHDLVRVIRQQI 120 130 140 150 160 170 180 190 200 pF1KB6 EQECPPSPEPTRKEKDKK-GCH---CVIF .. . . :. . :. : : :::. XP_016 PEKSQKKKKKTKWRGDRATGTHKLQCVIL 180 190 200 >>NP_001239019 (OMIM: 608435) ras-related protein M-Ras (208 aa) initn: 713 init1: 644 opt: 729 Z-score: 798.1 bits: 154.6 E(85289): 1e-37 Smith-Waterman score: 729; 58.5% identity (82.1% similar) in 195 aa overlap (15-204:14-208) 10 20 30 40 50 60 pF1KB6 MAAAGWRDGSGQEKYRLVVVGGGGVGKSALTIQFIQSYFVTDYDPTIEDSYTKQCVIDDR :.::::: ::::::::::::.:. :: :::::::::: :. ::.. NP_001 MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQ 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 AARLDILDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYKFQRQILRVKDRDEF : ::.:::::::::.::::::::::.:::.:.::::..:::.. .:.. :::::::. : NP_001 WAILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESF 60 70 80 90 100 110 130 140 150 160 170 pF1KB6 PMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAK-IRMNVDQAFHELVRVIRKFQ ::::..::.:: : :..:.:.:...: . .. :.:.::: .:::.:::.::::::. NP_001 PMILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDPPLNVDKAFHDLVRVIRQQI 120 130 140 150 160 170 180 190 200 pF1KB6 EQECPPSPEPTRKEKDKK-GCH---CVIF .. . . :. . :. : : :::. NP_001 PEKSQKKKKKTKWRGDRATGTHKLQCVIL 180 190 200 204 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 13:12:30 2016 done: Fri Nov 4 13:12:31 2016 Total Scan time: 5.400 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]