FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6915, 205 aa 1>>>pF1KB6915 205 - 205 aa - 205 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2665+/-0.000833; mu= 13.5090+/- 0.050 mean_var=69.2611+/-13.781, 0's: 0 Z-trim(107.8): 180 B-trim: 314 in 1/48 Lambda= 0.154110 statistics sampled from 9595 (9791) to 9595 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.681), E-opt: 0.2 (0.301), width: 16 Scan time: 2.030 The best scores are: opt bits E(32554) CCDS33191.1 RHOQ gene_id:23433|Hs108|chr2 ( 205) 1392 318.2 2.3e-87 CCDS9757.1 RHOJ gene_id:57381|Hs108|chr14 ( 214) 1032 238.1 2.9e-63 CCDS222.1 CDC42 gene_id:998|Hs108|chr1 ( 191) 880 204.3 4e-53 CCDS221.1 CDC42 gene_id:998|Hs108|chr1 ( 191) 879 204.1 4.6e-53 CCDS5348.1 RAC1 gene_id:5879|Hs108|chr7 ( 192) 831 193.4 7.6e-50 CCDS11798.1 RAC3 gene_id:5881|Hs108|chr17 ( 192) 829 193.0 1e-49 CCDS13945.1 RAC2 gene_id:5880|Hs108|chr22 ( 192) 802 187.0 6.6e-48 CCDS7748.1 RHOG gene_id:391|Hs108|chr11 ( 191) 724 169.6 1.1e-42 CCDS10068.1 RHOV gene_id:171177|Hs108|chr15 ( 236) 695 163.2 1.1e-40 CCDS1699.1 RHOB gene_id:388|Hs108|chr2 ( 196) 689 161.9 2.5e-40 CCDS1575.1 RHOU gene_id:58480|Hs108|chr1 ( 258) 683 160.6 7.7e-40 CCDS2795.1 RHOA gene_id:387|Hs108|chr3 ( 193) 679 159.6 1.1e-39 CCDS854.1 RHOC gene_id:389|Hs108|chr1 ( 193) 670 157.6 4.5e-39 CCDS9222.1 RHOF gene_id:54509|Hs108|chr12 ( 211) 601 142.3 2e-34 CCDS8155.1 RHOD gene_id:29984|Hs108|chr11 ( 210) 582 138.1 3.8e-33 CCDS82775.1 RHOA gene_id:387|Hs108|chr3 ( 187) 575 136.5 1e-32 CCDS2190.1 RND3 gene_id:390|Hs108|chr2 ( 244) 544 129.7 1.5e-30 CCDS11452.1 RND2 gene_id:8153|Hs108|chr17 ( 227) 504 120.8 6.7e-28 CCDS3458.1 RHOH gene_id:399|Hs108|chr4 ( 191) 495 118.7 2.3e-27 CCDS5349.1 RAC1 gene_id:5879|Hs108|chr7 ( 211) 469 113.0 1.4e-25 CCDS8771.1 RND1 gene_id:27289|Hs108|chr12 ( 232) 446 107.9 5.2e-24 CCDS6034.1 RHOBTB2 gene_id:23221|Hs108|chr8 ( 727) 307 77.3 2.6e-14 CCDS55211.1 RHOBTB2 gene_id:23221|Hs108|chr8 ( 734) 307 77.3 2.6e-14 CCDS55210.1 RHOBTB2 gene_id:23221|Hs108|chr8 ( 749) 307 77.3 2.7e-14 CCDS7261.1 RHOBTB1 gene_id:9886|Hs108|chr10 ( 696) 304 76.6 4e-14 CCDS5460.1 RALA gene_id:5898|Hs108|chr7 ( 206) 269 68.5 3.3e-12 CCDS8703.1 KRAS gene_id:3845|Hs108|chr12 ( 189) 261 66.7 1.1e-11 CCDS46306.1 RAB1A gene_id:5861|Hs108|chr2 ( 205) 260 66.5 1.3e-11 CCDS2131.1 RALB gene_id:5899|Hs108|chr2 ( 206) 256 65.6 2.4e-11 CCDS7699.1 HRAS gene_id:3265|Hs108|chr11 ( 170) 254 65.1 2.8e-11 CCDS7698.1 HRAS gene_id:3265|Hs108|chr11 ( 189) 254 65.1 3.1e-11 CCDS31613.1 RAB1B gene_id:81876|Hs108|chr11 ( 201) 254 65.2 3.3e-11 CCDS14632.1 RAP2C gene_id:57826|Hs108|chrX ( 183) 253 64.9 3.5e-11 CCDS8702.1 KRAS gene_id:3845|Hs108|chr12 ( 188) 252 64.7 4.2e-11 CCDS3170.1 RAP2B gene_id:5912|Hs108|chr3 ( 183) 250 64.2 5.6e-11 CCDS9485.1 RAP2A gene_id:5911|Hs108|chr13 ( 183) 250 64.2 5.6e-11 CCDS877.1 NRAS gene_id:4893|Hs108|chr1 ( 189) 249 64.0 6.7e-11 CCDS1720.1 RAB10 gene_id:10890|Hs108|chr2 ( 200) 249 64.0 7e-11 >>CCDS33191.1 RHOQ gene_id:23433|Hs108|chr2 (205 aa) initn: 1392 init1: 1392 opt: 1392 Z-score: 1682.1 bits: 318.2 E(32554): 2.3e-87 Smith-Waterman score: 1392; 100.0% identity (100.0% similar) in 205 aa overlap (1-205:1-205) 10 20 30 40 50 60 pF1KB6 MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQYLLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQYLLG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 LYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELKEYAPNVPFLLIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 LYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELKEYAPNVPFLLIG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 TQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVECSALTQKGLKTVFDEAII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS33 TQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVECSALTQKGLKTVFDEAII 130 140 150 160 170 180 190 200 pF1KB6 AILTPKKHTVKKRIGSRCINCCLIT ::::::::::::::::::::::::: CCDS33 AILTPKKHTVKKRIGSRCINCCLIT 190 200 >>CCDS9757.1 RHOJ gene_id:57381|Hs108|chr14 (214 aa) initn: 1041 init1: 1013 opt: 1032 Z-score: 1249.2 bits: 238.1 E(32554): 2.9e-63 Smith-Waterman score: 1032; 79.6% identity (90.3% similar) in 196 aa overlap (9-204:21-213) 10 20 30 40 pF1KB6 MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAV :::::::::::::::::::::::::::::::::::::::: CCDS97 MNCKEGTDSSCGCRGNDEKKMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAV 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB6 SVTVGGKQYLLGLYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELK .:::::::.:::::::::::::..::::::: :::::::::::::::..::.:::::::: CCDS97 TVTVGGKQHLLGLYDTAGQEDYNQLRPLSYPNTDVFLICFSVVNPASYHNVQEEWVPELK 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB6 EYAPNVPFLLIGTQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVECSALTQ . :.::..:::::::::::::::::: :::::. :.: :::: ::: ::.::::::: CCDS97 DCMPHVPYVLIGTQIDLRDDPKTLARLLYMKEKPLTYEHGVKLAKAIGAQCYLECSALTQ 130 140 150 160 170 180 170 180 190 200 pF1KB6 KGLKTVFDEAIIAILTPKKHTVKKRIGSRCINCCLIT ::::.::::::..:. ::: ::. :. .:: : CCDS97 KGLKAVFDEAILTIFHPKK---KKKRCSEGHSCCSII 190 200 210 >>CCDS222.1 CDC42 gene_id:998|Hs108|chr1 (191 aa) initn: 888 init1: 868 opt: 880 Z-score: 1067.3 bits: 204.3 E(32554): 4e-53 Smith-Waterman score: 880; 64.9% identity (84.5% similar) in 194 aa overlap (10-203:4-190) 10 20 30 40 50 60 pF1KB6 MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQYLLG .::::::::::::::::.::... :: ::::::::.:::.: .::. : :: CCDS22 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLG 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 LYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELKEYAPNVPFLLIG :.:::::::::::::::::.:::::.:::::.:.::.::::.::::. .. :..::::.: CCDS22 LFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 TQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVECSALTQKGLKTVFDEAII :::::::::.:. .: :.::: : ..:::... : :::::::::.:::.::::::. CCDS22 TQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAIL 120 130 140 150 160 170 190 200 pF1KB6 AILTPKKHTVKKRIGSRCINCCLIT : : : . :.. ::. CCDS22 AALEPPETQPKRK-------CCIF 180 190 >>CCDS221.1 CDC42 gene_id:998|Hs108|chr1 (191 aa) initn: 891 init1: 871 opt: 879 Z-score: 1066.1 bits: 204.1 E(32554): 4.6e-53 Smith-Waterman score: 879; 67.4% identity (86.3% similar) in 190 aa overlap (10-199:4-189) 10 20 30 40 50 60 pF1KB6 MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQYLLG .::::::::::::::::.::... :: ::::::::.:::.: .::. : :: CCDS22 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLG 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 LYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELKEYAPNVPFLLIG :.:::::::::::::::::.:::::.:::::.:.::.::::.::::. .. :..::::.: CCDS22 LFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 TQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVECSALTQKGLKTVFDEAII :::::::::.:. .: :.::: : ..:::... : :::::::::::::.::::::. CCDS22 TQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAIL 120 130 140 150 160 170 190 200 pF1KB6 AILTPKKHTVKKRIGSRCINCCLIT : : : . :.: ::. CCDS22 AALEPPEPK-KSR---RCVLL 180 190 >>CCDS5348.1 RAC1 gene_id:5879|Hs108|chr7 (192 aa) initn: 826 init1: 826 opt: 831 Z-score: 1008.4 bits: 193.4 E(32554): 7.6e-50 Smith-Waterman score: 831; 64.2% identity (83.7% similar) in 190 aa overlap (10-199:4-190) 10 20 30 40 50 60 pF1KB6 MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQYLLG .::::::::::::::::.::...::: ::.:::::.:...: : :: :: CCDS53 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLG 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 LYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELKEYAPNVPFLLIG :.:::::::::::::::::.:::::::::.:.::::.::. .: ::.... ::.:..:.: CCDS53 LWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 TQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVECSALTQKGLKTVFDEAII :..::::: :. .:.. : :: :: .:::::: :.:::::::.:::::::::: CCDS53 TKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIR 120 130 140 150 160 170 190 200 pF1KB6 AILTPKKHTVKKRIGSRCINCCLIT :.: : :::: .:. CCDS53 AVLCPPP--VKKR-KRKCLLL 180 190 >>CCDS11798.1 RAC3 gene_id:5881|Hs108|chr17 (192 aa) initn: 849 init1: 817 opt: 829 Z-score: 1006.0 bits: 193.0 E(32554): 1e-49 Smith-Waterman score: 829; 64.6% identity (83.6% similar) in 189 aa overlap (10-198:4-189) 10 20 30 40 50 60 pF1KB6 MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQYLLG .::::::::::::::::.::...::: ::.:::::.:...: : :: :: CCDS11 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLG 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 LYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELKEYAPNVPFLLIG :.:::::::::::::::::.:::::::::.:.::::.::. .: ::.... :..:.::.: CCDS11 LWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPHTPILLVG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 TQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVECSALTQKGLKTVFDEAII :..::::: :. :: : : :: :: .:.:::. :.:::::::.:::::::::: CCDS11 TKLDLRDDKDTIERLRDKKLAPITYPQGLAMAREIGSVKYLECSALTQRGLKTVFDEAIR 120 130 140 150 160 170 190 200 pF1KB6 AILTPKKHTVKKRIGSRCINCCLIT :.: : ::: :..: CCDS11 AVLCPPP--VKKP-GKKCTVF 180 190 >>CCDS13945.1 RAC2 gene_id:5880|Hs108|chr22 (192 aa) initn: 838 init1: 800 opt: 802 Z-score: 973.5 bits: 187.0 E(32554): 6.6e-48 Smith-Waterman score: 802; 62.0% identity (83.4% similar) in 187 aa overlap (10-196:4-190) 10 20 30 40 50 60 pF1KB6 MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQYLLG .::::::::::::::::.::...::: ::.:::::.:...: : .: :: CCDS13 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLG 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 LYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELKEYAPNVPFLLIG :.:::::::::::::::::.:::::::::.:.:::..::. .: ::.... :..:..:.: CCDS13 LWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 TQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVECSALTQKGLKTVFDEAII :..::::: :. .:.. : :: :: ::::: . :.:::::::.:::::::::: CCDS13 TKLDLRDDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIR 120 130 140 150 160 170 190 200 pF1KB6 AILTPKKHTVKKRIGSRCINCCLIT :.: :. .:: : CCDS13 AVLCPQPTRQQKRACSLL 180 190 >>CCDS7748.1 RHOG gene_id:391|Hs108|chr11 (191 aa) initn: 748 init1: 714 opt: 724 Z-score: 879.8 bits: 169.6 E(32554): 1.1e-42 Smith-Waterman score: 724; 56.8% identity (81.1% similar) in 190 aa overlap (10-199:4-189) 10 20 30 40 50 60 pF1KB6 MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQYLLG .::::::::::::::::. :...:::.::.:::::.:... .: :. :. CCDS77 MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQSAVDGRTVNLN 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 LYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELKEYAPNVPFLLIG :.::::::.::::: ::::.:.::.::::...: :..::...: ::. .. :.::.::.: CCDS77 LWDTAGQEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVCHHCPDVPILLVG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 TQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVECSALTQKGLKTVFDEAII :. ::: .: :: ::... . :: .::: :::.: : :.::::: : :.: :: ::. CCDS77 TKKDLRAQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSALQQDGVKEVFAEAVR 120 130 140 150 160 170 190 200 pF1KB6 AILTPKKHTVKKRIGSRCINCCLIT :.:.: : :: : :: CCDS77 AVLNP---TPIKR-GRSCILL 180 190 >>CCDS10068.1 RHOV gene_id:171177|Hs108|chr15 (236 aa) initn: 667 init1: 509 opt: 695 Z-score: 843.7 bits: 163.2 E(32554): 1.1e-40 Smith-Waterman score: 695; 52.7% identity (75.1% similar) in 201 aa overlap (5-198:27-227) 10 20 30 pF1KB6 MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEY : : .:::.::::::::. :..::. ...: .: CCDS10 MPPRELSEAEPPPLRAPTPPPRRRSAPPELGIKCVLVGDGAVGKSSLIVSYTCNGYPARY 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB6 VPTVFDHYAVSVTVGGKQYLLGLYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQN ::..: ..:.: : : . :.:::::::.:::: : :: ::::: :::::.:.:::: CCDS10 RPTALDTFSVQVLVDGAPVRIELWDTAGQEDFDRLRSLCYPDTDVFLACFSVVQPSSFQN 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB6 VKEEWVPELKEYAPNVPFLLIGTQIDLRDDPKTLARLNDM-KEKPICVEQGQKLAKEIGA . :.:.::.. . :..: ::.::: ::::: ..: .:.. .: :. :.: ::..: : CCDS10 ITEKWLPEIRTHNPQAPVLLVGTQADLRDDVNVLIQLDQGGREGPVPQPQAQGLAEKIRA 130 140 150 160 170 180 160 170 180 190 200 pF1KB6 CCYVECSALTQKGLKTVFDEAIIAILTPKKHTVKK------RIGSRCINCCLIT :::.::::::::.:: ::: ::.. . : . :: : ::: CCDS10 CCYLECSALTQKNLKEVFDSAILSAIEHKARLEKKLNAKGVRTLSRCRWKKFFCFV 190 200 210 220 230 >>CCDS1699.1 RHOB gene_id:388|Hs108|chr2 (196 aa) initn: 699 init1: 637 opt: 689 Z-score: 837.6 bits: 161.9 E(32554): 2.5e-40 Smith-Waterman score: 689; 52.0% identity (78.0% similar) in 200 aa overlap (7-204:3-195) 10 20 30 40 50 60 pF1KB6 MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQYLLG :. : ::::::: ::::::. ...: ::: ::::::..:.... : ::: :. CCDS16 MAAIRKKLVVVGDGACGKTCLLIVFSKDEFPEVYVPTVFENYVADIEVDGKQVELA 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 LYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELKEYAPNVPFLLIG :.::::::::::::::::: :::.:.:::: .: :..:. :.::::.:.. ::::..:.. CCDS16 LWDTAGQEDYDRLRPLSYPDTDVILMCFSVDSPDSLENIPEKWVPEVKHFCPNVPIILVA 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 TQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVECSALTQKGLKTVFDEAII .. :::.: .. ..: ::..:. ...:. .: .: : :.:::: :..:.. ::. : CCDS16 NKKDLRSDEHVRTELARMKQEPVRTDDGRAMAVRIQAYDYLECSAKTKEGVREVFETATR 120 130 140 150 160 170 190 200 pF1KB6 AILTPKKHTVKKRIGSR--CINCCLIT : : .:: ::. ::::: . CCDS16 AAL-------QKRYGSQNGCINCCKVL 180 190 205 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 18:54:19 2016 done: Sat Nov 5 18:54:20 2016 Total Scan time: 2.030 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]