FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6915, 205 aa 1>>>pF1KB6915 205 - 205 aa - 205 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.6227+/-0.000399; mu= 17.5163+/- 0.025 mean_var=78.2785+/-16.003, 0's: 0 Z-trim(113.8): 398 B-trim: 1183 in 2/49 Lambda= 0.144962 statistics sampled from 22805 (23263) to 22805 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.659), E-opt: 0.2 (0.273), width: 16 Scan time: 5.310 The best scores are: opt bits E(85289) NP_036381 (OMIM: 605857) rho-related GTP-binding p ( 205) 1392 300.4 1.4e-81 XP_011531028 (OMIM: 605857) PREDICTED: rho-related ( 192) 1057 230.3 1.6e-60 XP_016859205 (OMIM: 605857) PREDICTED: rho-related ( 172) 1051 229.0 3.5e-60 NP_065714 (OMIM: 607653) rho-related GTP-binding p ( 214) 1032 225.1 6.5e-59 XP_011531030 (OMIM: 605857) PREDICTED: rho-related ( 157) 949 207.6 8.8e-54 NP_426359 (OMIM: 116952,616737) cell division cont ( 191) 880 193.3 2.2e-49 NP_001034891 (OMIM: 116952,616737) cell division c ( 191) 879 193.1 2.6e-49 NP_001782 (OMIM: 116952,616737) cell division cont ( 191) 879 193.1 2.6e-49 XP_006720277 (OMIM: 607653) PREDICTED: rho-related ( 176) 846 186.1 2.9e-47 NP_008839 (OMIM: 602048) ras-related C3 botulinum ( 192) 831 183.0 2.7e-46 NP_005043 (OMIM: 602050) ras-related C3 botulinum ( 192) 829 182.6 3.6e-46 NP_002863 (OMIM: 602049,608203) ras-related C3 bot ( 192) 802 177.0 1.8e-44 NP_001656 (OMIM: 179505) rho-related GTP-binding p ( 191) 724 160.6 1.5e-39 XP_016873208 (OMIM: 179505) PREDICTED: rho-related ( 191) 724 160.6 1.5e-39 XP_005252973 (OMIM: 179505) PREDICTED: rho-related ( 191) 724 160.6 1.5e-39 NP_001303236 (OMIM: 602050) ras-related C3 botulin ( 170) 697 154.9 6.8e-38 NP_004031 (OMIM: 165370) rho-related GTP-binding p ( 196) 689 153.3 2.4e-37 NP_067028 (OMIM: 606366) rho-related GTP-binding p ( 258) 683 152.2 6.9e-37 NP_001300870 (OMIM: 165390) transforming protein R ( 193) 679 151.2 1e-36 NP_001655 (OMIM: 165390) transforming protein RhoA ( 193) 679 151.2 1e-36 NP_001036144 (OMIM: 165380) rho-related GTP-bindin ( 193) 670 149.3 3.7e-36 NP_001036143 (OMIM: 165380) rho-related GTP-bindin ( 193) 670 149.3 3.7e-36 NP_786886 (OMIM: 165380) rho-related GTP-binding p ( 193) 670 149.3 3.7e-36 XP_006724349 (OMIM: 602049,608203) PREDICTED: ras- ( 161) 657 146.5 2.2e-35 NP_055393 (OMIM: 605781) rho-related GTP-binding p ( 210) 582 131.0 1.4e-30 NP_001300872 (OMIM: 165390) transforming protein R ( 187) 575 129.5 3.5e-30 NP_001241667 (OMIM: 602924) rho-related GTP-bindin ( 244) 544 123.1 3.7e-28 NP_005159 (OMIM: 602924) rho-related GTP-binding p ( 244) 544 123.1 3.7e-28 NP_005431 (OMIM: 601555) rho-related GTP-binding p ( 227) 504 114.7 1.2e-25 XP_011523618 (OMIM: 601555) PREDICTED: rho-related ( 234) 504 114.7 1.2e-25 NP_004301 (OMIM: 602037) rho-related GTP-binding p ( 191) 495 112.7 3.8e-25 NP_001265298 (OMIM: 602037) rho-related GTP-bindin ( 191) 495 112.7 3.8e-25 NP_001265295 (OMIM: 602037) rho-related GTP-bindin ( 191) 495 112.7 3.8e-25 NP_001265297 (OMIM: 602037) rho-related GTP-bindin ( 191) 495 112.7 3.8e-25 NP_001265289 (OMIM: 602037) rho-related GTP-bindin ( 191) 495 112.7 3.8e-25 XP_011511994 (OMIM: 602037) PREDICTED: rho-related ( 191) 495 112.7 3.8e-25 NP_001265294 (OMIM: 602037) rho-related GTP-bindin ( 191) 495 112.7 3.8e-25 XP_016863678 (OMIM: 602037) PREDICTED: rho-related ( 191) 495 112.7 3.8e-25 NP_001265296 (OMIM: 602037) rho-related GTP-bindin ( 191) 495 112.7 3.8e-25 NP_001265292 (OMIM: 602037) rho-related GTP-bindin ( 191) 495 112.7 3.8e-25 NP_001265290 (OMIM: 602037) rho-related GTP-bindin ( 191) 495 112.7 3.8e-25 XP_016863677 (OMIM: 602037) PREDICTED: rho-related ( 191) 495 112.7 3.8e-25 NP_001265291 (OMIM: 602037) rho-related GTP-bindin ( 191) 495 112.7 3.8e-25 NP_001265288 (OMIM: 602037) rho-related GTP-bindin ( 191) 495 112.7 3.8e-25 NP_001265293 (OMIM: 602037) rho-related GTP-bindin ( 191) 495 112.7 3.8e-25 NP_061485 (OMIM: 602048) ras-related C3 botulinum ( 211) 469 107.4 1.8e-23 XP_005264286 (OMIM: 605857) PREDICTED: rho-related ( 118) 453 103.7 1.2e-22 NP_055285 (OMIM: 609038) rho-related GTP-binding p ( 232) 446 102.6 5.3e-22 NP_001300873 (OMIM: 165390) transforming protein R ( 173) 435 100.1 2.2e-21 XP_011523619 (OMIM: 601555) PREDICTED: rho-related ( 206) 413 95.6 5.9e-20 >>NP_036381 (OMIM: 605857) rho-related GTP-binding prote (205 aa) initn: 1392 init1: 1392 opt: 1392 Z-score: 1585.8 bits: 300.4 E(85289): 1.4e-81 Smith-Waterman score: 1392; 100.0% identity (100.0% similar) in 205 aa overlap (1-205:1-205) 10 20 30 40 50 60 pF1KB6 MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQYLLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQYLLG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 LYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELKEYAPNVPFLLIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 LYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELKEYAPNVPFLLIG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 TQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVECSALTQKGLKTVFDEAII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 TQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVECSALTQKGLKTVFDEAII 130 140 150 160 170 180 190 200 pF1KB6 AILTPKKHTVKKRIGSRCINCCLIT ::::::::::::::::::::::::: NP_036 AILTPKKHTVKKRIGSRCINCCLIT 190 200 >>XP_011531028 (OMIM: 605857) PREDICTED: rho-related GTP (192 aa) initn: 1052 init1: 1052 opt: 1057 Z-score: 1207.5 bits: 230.3 E(85289): 1.6e-60 Smith-Waterman score: 1057; 93.6% identity (96.5% similar) in 171 aa overlap (1-171:1-166) 10 20 30 40 50 60 pF1KB6 MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQYLLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQYLLG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 LYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELKEYAPNVPFLLIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELKEYAPNVPFLLIG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 TQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVECSALTQKGLKTVFDEAII ::::::::::::::::::::::::::::::::::..: .:. ::.:: XP_011 TQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEMSA--HVDA---TQQGLCSFVQFTDI 130 140 150 160 170 190 200 pF1KB6 AILTPKKHTVKKRIGSRCINCCLIT XP_011 SPGPKQCLTYSRYPVNM 180 190 >>XP_016859205 (OMIM: 605857) PREDICTED: rho-related GTP (172 aa) initn: 1064 init1: 1049 opt: 1051 Z-score: 1201.3 bits: 229.0 E(85289): 3.5e-60 Smith-Waterman score: 1051; 95.7% identity (96.9% similar) in 163 aa overlap (1-161:1-162) 10 20 30 40 50 60 pF1KB6 MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQYLLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQYLLG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 LYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELKEYAPNVPFLLIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELKEYAPNVPFLLIG 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 TQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGAC--CYVECSALTQKGLKTVFDEA ::::::::::::::::::::::::::::::::::. : : . XP_016 TQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEV-ECFTCIISFNPCMNSVR 130 140 150 160 170 180 190 200 pF1KB6 IIAILTPKKHTVKKRIGSRCINCCLIT >>NP_065714 (OMIM: 607653) rho-related GTP-binding prote (214 aa) initn: 1041 init1: 1013 opt: 1032 Z-score: 1178.7 bits: 225.1 E(85289): 6.5e-59 Smith-Waterman score: 1032; 79.6% identity (90.3% similar) in 196 aa overlap (9-204:21-213) 10 20 30 40 pF1KB6 MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAV :::::::::::::::::::::::::::::::::::::::: NP_065 MNCKEGTDSSCGCRGNDEKKMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAV 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB6 SVTVGGKQYLLGLYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELK .:::::::.:::::::::::::..::::::: :::::::::::::::..::.:::::::: NP_065 TVTVGGKQHLLGLYDTAGQEDYNQLRPLSYPNTDVFLICFSVVNPASYHNVQEEWVPELK 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB6 EYAPNVPFLLIGTQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVECSALTQ . :.::..:::::::::::::::::: :::::. :.: :::: ::: ::.::::::: NP_065 DCMPHVPYVLIGTQIDLRDDPKTLARLLYMKEKPLTYEHGVKLAKAIGAQCYLECSALTQ 130 140 150 160 170 180 170 180 190 200 pF1KB6 KGLKTVFDEAIIAILTPKKHTVKKRIGSRCINCCLIT ::::.::::::..:. ::: ::. :. .:: : NP_065 KGLKAVFDEAILTIFHPKK---KKKRCSEGHSCCSII 190 200 210 >>XP_011531030 (OMIM: 605857) PREDICTED: rho-related GTP (157 aa) initn: 949 init1: 949 opt: 949 Z-score: 1086.5 bits: 207.6 E(85289): 8.8e-54 Smith-Waterman score: 949; 98.6% identity (99.3% similar) in 142 aa overlap (64-205:16-157) 40 50 60 70 80 90 pF1KB6 FPEEYVPTVFDHYAVSVTVGGKQYLLGLYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNP :. ::::::::::::::::::::::::::: XP_011 MPTTPSRRSTCPPSSTTTQEDYDRLRPLSYPMTDVFLICFSVVNP 10 20 30 40 100 110 120 130 140 150 pF1KB6 ASFQNVKEEWVPELKEYAPNVPFLLIGTQIDLRDDPKTLARLNDMKEKPICVEQGQKLAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASFQNVKEEWVPELKEYAPNVPFLLIGTQIDLRDDPKTLARLNDMKEKPICVEQGQKLAK 50 60 70 80 90 100 160 170 180 190 200 pF1KB6 EIGACCYVECSALTQKGLKTVFDEAIIAILTPKKHTVKKRIGSRCINCCLIT :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EIGACCYVECSALTQKGLKTVFDEAIIAILTPKKHTVKKRIGSRCINCCLIT 110 120 130 140 150 >>NP_426359 (OMIM: 116952,616737) cell division control (191 aa) initn: 888 init1: 868 opt: 880 Z-score: 1007.5 bits: 193.3 E(85289): 2.2e-49 Smith-Waterman score: 880; 64.9% identity (84.5% similar) in 194 aa overlap (10-203:4-190) 10 20 30 40 50 60 pF1KB6 MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQYLLG .::::::::::::::::.::... :: ::::::::.:::.: .::. : :: NP_426 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLG 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 LYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELKEYAPNVPFLLIG :.:::::::::::::::::.:::::.:::::.:.::.::::.::::. .. :..::::.: NP_426 LFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 TQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVECSALTQKGLKTVFDEAII :::::::::.:. .: :.::: : ..:::... : :::::::::.:::.::::::. NP_426 TQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAIL 120 130 140 150 160 170 190 200 pF1KB6 AILTPKKHTVKKRIGSRCINCCLIT : : : . :.. ::. NP_426 AALEPPETQPKRK-------CCIF 180 190 >>NP_001034891 (OMIM: 116952,616737) cell division contr (191 aa) initn: 891 init1: 871 opt: 879 Z-score: 1006.4 bits: 193.1 E(85289): 2.6e-49 Smith-Waterman score: 879; 67.4% identity (86.3% similar) in 190 aa overlap (10-199:4-189) 10 20 30 40 50 60 pF1KB6 MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQYLLG .::::::::::::::::.::... :: ::::::::.:::.: .::. : :: NP_001 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLG 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 LYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELKEYAPNVPFLLIG :.:::::::::::::::::.:::::.:::::.:.::.::::.::::. .. :..::::.: NP_001 LFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 TQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVECSALTQKGLKTVFDEAII :::::::::.:. .: :.::: : ..:::... : :::::::::::::.::::::. NP_001 TQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAIL 120 130 140 150 160 170 190 200 pF1KB6 AILTPKKHTVKKRIGSRCINCCLIT : : : . :.: ::. NP_001 AALEPPEPK-KSR---RCVLL 180 190 >>NP_001782 (OMIM: 116952,616737) cell division control (191 aa) initn: 891 init1: 871 opt: 879 Z-score: 1006.4 bits: 193.1 E(85289): 2.6e-49 Smith-Waterman score: 879; 67.4% identity (86.3% similar) in 190 aa overlap (10-199:4-189) 10 20 30 40 50 60 pF1KB6 MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQYLLG .::::::::::::::::.::... :: ::::::::.:::.: .::. : :: NP_001 MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLG 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 LYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELKEYAPNVPFLLIG :.:::::::::::::::::.:::::.:::::.:.::.::::.::::. .. :..::::.: NP_001 LFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 TQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVECSALTQKGLKTVFDEAII :::::::::.:. .: :.::: : ..:::... : :::::::::::::.::::::. NP_001 TQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAIL 120 130 140 150 160 170 190 200 pF1KB6 AILTPKKHTVKKRIGSRCINCCLIT : : : . :.: ::. NP_001 AALEPPEPK-KSR---RCVLL 180 190 >>XP_006720277 (OMIM: 607653) PREDICTED: rho-related GTP (176 aa) initn: 863 init1: 844 opt: 846 Z-score: 969.5 bits: 186.1 E(85289): 2.9e-47 Smith-Waterman score: 846; 83.3% identity (93.3% similar) in 150 aa overlap (9-158:21-169) 10 20 30 40 pF1KB6 MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAV :::::::::::::::::::::::::::::::::::::::: XP_006 MNCKEGTDSSCGCRGNDEKKMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAV 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB6 SVTVGGKQYLLGLYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELK .:::::::.:::::::::::::..::::::: :::::::::::::::..::.:::::::: XP_006 TVTVGGKQHLLGLYDTAGQEDYNQLRPLSYPNTDVFLICFSVVNPASYHNVQEEWVPELK 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB6 EYAPNVPFLLIGTQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVECSALTQ . :.::..:::::::::::::::::: :::::. :.: :::: . .: XP_006 DCMPHVPYVLIGTQIDLRDDPKTLARLLYMKEKPLTYEHGVKLAKAV-SCMRTSHNT 130 140 150 160 170 170 180 190 200 pF1KB6 KGLKTVFDEAIIAILTPKKHTVKKRIGSRCINCCLIT >>NP_008839 (OMIM: 602048) ras-related C3 botulinum toxi (192 aa) initn: 826 init1: 826 opt: 831 Z-score: 952.1 bits: 183.0 E(85289): 2.7e-46 Smith-Waterman score: 831; 64.2% identity (83.7% similar) in 190 aa overlap (10-199:4-190) 10 20 30 40 50 60 pF1KB6 MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQYLLG .::::::::::::::::.::...::: ::.:::::.:...: : :: :: NP_008 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLG 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 LYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELKEYAPNVPFLLIG :.:::::::::::::::::.:::::::::.:.::::.::. .: ::.... ::.:..:.: NP_008 LWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 TQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVECSALTQKGLKTVFDEAII :..::::: :. .:.. : :: :: .:::::: :.:::::::.:::::::::: NP_008 TKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIR 120 130 140 150 160 170 190 200 pF1KB6 AILTPKKHTVKKRIGSRCINCCLIT :.: : :::: .:. NP_008 AVLCPPP--VKKR-KRKCLLL 180 190 205 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 18:54:20 2016 done: Sat Nov 5 18:54:21 2016 Total Scan time: 5.310 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]