FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6920, 226 aa 1>>>pF1KB6920 226 - 226 aa - 226 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.2869+/-0.000555; mu= 2.1629+/- 0.033 mean_var=180.2803+/-42.547, 0's: 0 Z-trim(112.5): 823 B-trim: 407 in 1/48 Lambda= 0.095521 statistics sampled from 20359 (21415) to 20359 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.622), E-opt: 0.2 (0.251), width: 16 Scan time: 6.240 The best scores are: opt bits E(85289) NP_002805 (OMIM: 300880) 26S proteasome non-ATPase ( 226) 1472 215.6 5.5e-56 NP_736606 (OMIM: 300880) 26S proteasome non-ATPase ( 151) 985 148.3 6.7e-36 XP_016871638 (OMIM: 600465,615493) PREDICTED: anky (1720) 401 68.9 6.1e-11 XP_016871637 (OMIM: 600465,615493) PREDICTED: anky (1725) 401 68.9 6.1e-11 XP_016871636 (OMIM: 600465,615493) PREDICTED: anky (1735) 401 68.9 6.2e-11 XP_016871635 (OMIM: 600465,615493) PREDICTED: anky (1737) 401 68.9 6.2e-11 XP_016871634 (OMIM: 600465,615493) PREDICTED: anky (1738) 401 68.9 6.2e-11 XP_016871633 (OMIM: 600465,615493) PREDICTED: anky (1741) 401 68.9 6.2e-11 XP_016871632 (OMIM: 600465,615493) PREDICTED: anky (1742) 401 68.9 6.2e-11 XP_016871631 (OMIM: 600465,615493) PREDICTED: anky (1747) 401 68.9 6.2e-11 XP_016871630 (OMIM: 600465,615493) PREDICTED: anky (1751) 401 68.9 6.2e-11 XP_016871629 (OMIM: 600465,615493) PREDICTED: anky (1763) 401 68.9 6.2e-11 XP_016871628 (OMIM: 600465,615493) PREDICTED: anky (1764) 401 68.9 6.2e-11 XP_016871627 (OMIM: 600465,615493) PREDICTED: anky (1785) 401 68.9 6.3e-11 XP_016871626 (OMIM: 600465,615493) PREDICTED: anky (1786) 401 68.9 6.3e-11 XP_016871625 (OMIM: 600465,615493) PREDICTED: anky (1795) 401 68.9 6.3e-11 XP_016871624 (OMIM: 600465,615493) PREDICTED: anky (1838) 401 68.9 6.4e-11 XP_016871623 (OMIM: 600465,615493) PREDICTED: anky (1845) 401 68.9 6.4e-11 XP_016871622 (OMIM: 600465,615493) PREDICTED: anky (1850) 401 68.9 6.4e-11 XP_016871621 (OMIM: 600465,615493) PREDICTED: anky (1855) 401 68.9 6.4e-11 NP_001191332 (OMIM: 600465,615493) ankyrin-3 isofo (1861) 401 68.9 6.5e-11 XP_016871620 (OMIM: 600465,615493) PREDICTED: anky (1862) 401 68.9 6.5e-11 XP_016871619 (OMIM: 600465,615493) PREDICTED: anky (1866) 401 68.9 6.5e-11 NP_001307803 (OMIM: 600465,615493) ankyrin-3 isofo (1867) 401 68.9 6.5e-11 NP_001191333 (OMIM: 600465,615493) ankyrin-3 isofo (1868) 401 68.9 6.5e-11 XP_005269772 (OMIM: 600465,615493) PREDICTED: anky (1885) 401 68.9 6.5e-11 XP_016871618 (OMIM: 600465,615493) PREDICTED: anky (1888) 401 68.9 6.5e-11 XP_016871617 (OMIM: 600465,615493) PREDICTED: anky (1889) 401 68.9 6.5e-11 XP_006717865 (OMIM: 600465,615493) PREDICTED: anky (1898) 401 68.9 6.6e-11 XP_016871616 (OMIM: 600465,615493) PREDICTED: anky (2603) 401 69.1 8.2e-11 XP_016871615 (OMIM: 600465,615493) PREDICTED: anky (2612) 401 69.1 8.2e-11 XP_016871614 (OMIM: 600465,615493) PREDICTED: anky (2646) 401 69.1 8.3e-11 XP_016871613 (OMIM: 600465,615493) PREDICTED: anky (2647) 401 69.1 8.3e-11 XP_016871612 (OMIM: 600465,615493) PREDICTED: anky (2655) 401 69.1 8.3e-11 XP_011538011 (OMIM: 600465,615493) PREDICTED: anky (2656) 401 69.1 8.3e-11 XP_016871611 (OMIM: 600465,615493) PREDICTED: anky (2728) 401 69.1 8.4e-11 XP_006717859 (OMIM: 600465,615493) PREDICTED: anky (2758) 401 69.1 8.5e-11 XP_011538010 (OMIM: 600465,615493) PREDICTED: anky (2759) 401 69.1 8.5e-11 XP_016871610 (OMIM: 600465,615493) PREDICTED: anky (3945) 401 69.2 1.1e-10 XP_016871609 (OMIM: 600465,615493) PREDICTED: anky (3953) 401 69.2 1.1e-10 XP_016871608 (OMIM: 600465,615493) PREDICTED: anky (3954) 401 69.2 1.1e-10 XP_016871607 (OMIM: 600465,615493) PREDICTED: anky (4057) 401 69.3 1.1e-10 NP_066267 (OMIM: 600465,615493) ankyrin-3 isoform (4377) 401 69.3 1.2e-10 XP_016871639 (OMIM: 600465,615493) PREDICTED: anky (4379) 401 69.3 1.2e-10 XP_016871606 (OMIM: 600465,615493) PREDICTED: anky (4400) 401 69.3 1.2e-10 XP_016871605 (OMIM: 600465,615493) PREDICTED: anky (4401) 401 69.3 1.2e-10 XP_016871604 (OMIM: 600465,615493) PREDICTED: anky (4478) 401 69.3 1.2e-10 XP_016871603 (OMIM: 600465,615493) PREDICTED: anky (4487) 401 69.3 1.2e-10 XP_016871602 (OMIM: 600465,615493) PREDICTED: anky (4495) 401 69.3 1.2e-10 XP_016871601 (OMIM: 600465,615493) PREDICTED: anky (4499) 401 69.3 1.2e-10 >>NP_002805 (OMIM: 300880) 26S proteasome non-ATPase reg (226 aa) initn: 1472 init1: 1472 opt: 1472 Z-score: 1126.1 bits: 215.6 E(85289): 5.5e-56 Smith-Waterman score: 1472; 100.0% identity (100.0% similar) in 226 aa overlap (1-226:1-226) 10 20 30 40 50 60 pF1KB6 MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 IAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLAC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 IAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLAC 130 140 150 160 170 180 190 200 210 220 pF1KB6 DEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG :::::::::::::::::::::::::::::::::::::::::::::: NP_002 DEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG 190 200 210 220 >>NP_736606 (OMIM: 300880) 26S proteasome non-ATPase reg (151 aa) initn: 985 init1: 985 opt: 985 Z-score: 765.5 bits: 148.3 E(85289): 6.7e-36 Smith-Waterman score: 985; 100.0% identity (100.0% similar) in 149 aa overlap (1-149:1-149) 10 20 30 40 50 60 pF1KB6 MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_736 MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_736 QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 IAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLAC ::::::::::::::::::::::::::::: NP_736 IAVMLLEGGANPDAKDHYEATAMHRAAAKDT 130 140 150 >>XP_016871638 (OMIM: 600465,615493) PREDICTED: ankyrin- (1720 aa) initn: 1994 init1: 395 opt: 401 Z-score: 317.4 bits: 68.9 E(85289): 6.1e-11 Smith-Waterman score: 401; 39.2% identity (69.9% similar) in 176 aa overlap (36-211:544-719) 10 20 30 40 50 60 pF1KB6 SNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVP : . . : :: : . :. :....::: .. XP_016 SGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSAS 520 530 540 550 560 570 70 80 90 100 110 120 pF1KB6 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML . .: .:::.:: .... :: .::. .:. .:: :::: ::.::. .::. : XP_016 PDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTL 580 590 600 610 620 630 130 140 150 160 170 180 pF1KB6 LEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV :: ::. .: . ...: :: .:.. :. .:: .:..:... : :::::: .:.:: XP_016 LEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRV 640 650 660 670 680 690 190 200 210 220 pF1KB6 EEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG . :..::.::: . ..: :::.: XP_016 NVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQA 700 710 720 730 740 750 >-- initn: 1134 init1: 364 opt: 383 Z-score: 304.0 bits: 66.4 E(85289): 3.4e-10 Smith-Waterman score: 383; 33.3% identity (65.7% similar) in 216 aa overlap (11-225:290-503) 10 20 30 40 pF1KB6 MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDS :. : ::. :.. : .: . ... XP_016 KRGNANMVKLLLDRGAKIDAKTRDGLTPLHCG-ARSGH-EQVVEMLLDRAAPILSKTKNG 260 270 280 290 300 310 50 60 70 80 90 100 pF1KB6 RTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN . :: : .. : . :..::: .:::.: . . ::.:: :. ...:.:: : :. : XP_016 LSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPN 320 330 340 350 360 370 110 120 130 140 150 160 pF1KB6 AVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLY : :: :::: : .::: .. .::. ::. .: . : .: :: :..... :.. XP_016 AKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMH 380 390 400 410 420 430 170 180 190 200 210 pF1KB6 YKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV-AKGGLGLI . :: : ...:.: ::.: ..: .. ::..::.. . :...:::.. :. : . : XP_016 HGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADI 440 450 460 470 480 490 220 pF1KB6 LKRMVEG ...... XP_016 VQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAK 500 510 520 530 540 550 >-- initn: 427 init1: 266 opt: 319 Z-score: 256.3 bits: 57.6 E(85289): 1.5e-07 Smith-Waterman score: 332; 31.1% identity (66.7% similar) in 225 aa overlap (4-225:53-272) 10 20 30 pF1KB6 MEGCVSN-LMVCNLAYS-GKLEELKESILADKS : .: : . .:: . :..: ..: . . . XP_016 DANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREAN 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB6 LATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKA . . : . . :::: : ::..:.:. :. :. :: ... :..::..::. .. :.:: XP_016 VDAATKKGN-TALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKF 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB6 LLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGN :: .::. . ....: ::: : .... ... .:::. :.: . . :.: :: : . XP_016 LLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN----DTKGKVRLPALHIAARKDD 150 160 170 180 190 160 170 180 190 200 210 pF1KB6 LKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV : .:: ...... : ::::.: .. : ::....:.. . ... :::.: XP_016 TKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHV 200 210 220 230 240 250 220 pF1KB6 A-KGGLGLILKRMVEG : : : . ..: ... XP_016 ASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNG 260 270 280 290 300 310 >>XP_016871637 (OMIM: 600465,615493) PREDICTED: ankyrin- (1725 aa) initn: 1994 init1: 395 opt: 401 Z-score: 317.4 bits: 68.9 E(85289): 6.1e-11 Smith-Waterman score: 401; 39.2% identity (69.9% similar) in 176 aa overlap (36-211:544-719) 10 20 30 40 50 60 pF1KB6 SNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVP : . . : :: : . :. :....::: .. XP_016 SGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSAS 520 530 540 550 560 570 70 80 90 100 110 120 pF1KB6 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML . .: .:::.:: .... :: .::. .:. .:: :::: ::.::. .::. : XP_016 PDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTL 580 590 600 610 620 630 130 140 150 160 170 180 pF1KB6 LEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV :: ::. .: . ...: :: .:.. :. .:: .:..:... : :::::: .:.:: XP_016 LEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRV 640 650 660 670 680 690 190 200 210 220 pF1KB6 EEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG . :..::.::: . ..: :::.: XP_016 NVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQA 700 710 720 730 740 750 >-- initn: 1134 init1: 364 opt: 383 Z-score: 304.0 bits: 66.4 E(85289): 3.4e-10 Smith-Waterman score: 383; 33.3% identity (65.7% similar) in 216 aa overlap (11-225:290-503) 10 20 30 40 pF1KB6 MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDS :. : ::. :.. : .: . ... XP_016 KRGNANMVKLLLDRGAKIDAKTRDGLTPLHCG-ARSGH-EQVVEMLLDRAAPILSKTKNG 260 270 280 290 300 310 50 60 70 80 90 100 pF1KB6 RTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN . :: : .. : . :..::: .:::.: . . ::.:: :. ...:.:: : :. : XP_016 LSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPN 320 330 340 350 360 370 110 120 130 140 150 160 pF1KB6 AVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLY : :: :::: : .::: .. .::. ::. .: . : .: :: :..... :.. XP_016 AKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMH 380 390 400 410 420 430 170 180 190 200 210 pF1KB6 YKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV-AKGGLGLI . :: : ...:.: ::.: ..: .. ::..::.. . :...:::.. :. : . : XP_016 HGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADI 440 450 460 470 480 490 220 pF1KB6 LKRMVEG ...... XP_016 VQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAK 500 510 520 530 540 550 >-- initn: 427 init1: 266 opt: 319 Z-score: 256.3 bits: 57.6 E(85289): 1.5e-07 Smith-Waterman score: 332; 31.1% identity (66.7% similar) in 225 aa overlap (4-225:53-272) 10 20 30 pF1KB6 MEGCVSN-LMVCNLAYS-GKLEELKESILADKS : .: : . .:: . :..: ..: . . . XP_016 DANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREAN 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB6 LATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKA . . : . . :::: : ::..:.:. :. :. :: ... :..::..::. .. :.:: XP_016 VDAATKKGN-TALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKF 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB6 LLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGN :: .::. . ....: ::: : .... ... .:::. :.: . . :.: :: : . XP_016 LLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN----DTKGKVRLPALHIAARKDD 150 160 170 180 190 160 170 180 190 200 210 pF1KB6 LKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV : .:: ...... : ::::.: .. : ::....:.. . ... :::.: XP_016 TKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHV 200 210 220 230 240 250 220 pF1KB6 A-KGGLGLILKRMVEG : : : . ..: ... XP_016 ASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNG 260 270 280 290 300 310 >>XP_016871636 (OMIM: 600465,615493) PREDICTED: ankyrin- (1735 aa) initn: 1994 init1: 395 opt: 401 Z-score: 317.3 bits: 68.9 E(85289): 6.2e-11 Smith-Waterman score: 401; 39.2% identity (69.9% similar) in 176 aa overlap (36-211:561-736) 10 20 30 40 50 60 pF1KB6 SNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVP : . . : :: : . :. :....::: .. XP_016 SGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSAS 540 550 560 570 580 590 70 80 90 100 110 120 pF1KB6 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML . .: .:::.:: .... :: .::. .:. .:: :::: ::.::. .::. : XP_016 PDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTL 600 610 620 630 640 650 130 140 150 160 170 180 pF1KB6 LEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV :: ::. .: . ...: :: .:.. :. .:: .:..:... : :::::: .:.:: XP_016 LEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRV 660 670 680 690 700 710 190 200 210 220 pF1KB6 EEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG . :..::.::: . ..: :::.: XP_016 NVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQA 720 730 740 750 760 770 >-- initn: 1134 init1: 364 opt: 383 Z-score: 303.9 bits: 66.4 E(85289): 3.4e-10 Smith-Waterman score: 383; 33.3% identity (65.7% similar) in 216 aa overlap (11-225:307-520) 10 20 30 40 pF1KB6 MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDS :. : ::. :.. : .: . ... XP_016 KRGNANMVKLLLDRGAKIDAKTRDGLTPLHCG-ARSGH-EQVVEMLLDRAAPILSKTKNG 280 290 300 310 320 330 50 60 70 80 90 100 pF1KB6 RTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN . :: : .. : . :..::: .:::.: . . ::.:: :. ...:.:: : :. : XP_016 LSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPN 340 350 360 370 380 390 110 120 130 140 150 160 pF1KB6 AVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLY : :: :::: : .::: .. .::. ::. .: . : .: :: :..... :.. XP_016 AKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMH 400 410 420 430 440 450 170 180 190 200 210 pF1KB6 YKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV-AKGGLGLI . :: : ...:.: ::.: ..: .. ::..::.. . :...:::.. :. : . : XP_016 HGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADI 460 470 480 490 500 510 220 pF1KB6 LKRMVEG ...... XP_016 VQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAK 520 530 540 550 560 570 >-- initn: 427 init1: 266 opt: 319 Z-score: 256.3 bits: 57.6 E(85289): 1.6e-07 Smith-Waterman score: 332; 31.1% identity (66.7% similar) in 225 aa overlap (4-225:70-289) 10 20 30 pF1KB6 MEGCVSN-LMVCNLAYS-GKLEELKESILADKS : .: : . .:: . :..: ..: . . . XP_016 DANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREAN 40 50 60 70 80 90 40 50 60 70 80 90 pF1KB6 LATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKA . . : . . :::: : ::..:.:. :. :. :: ... :..::..::. .. :.:: XP_016 VDAATKKGN-TALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKF 100 110 120 130 140 150 100 110 120 130 140 150 pF1KB6 LLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGN :: .::. . ....: ::: : .... ... .:::. :.: . . :.: :: : . XP_016 LLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN----DTKGKVRLPALHIAARKDD 160 170 180 190 200 210 160 170 180 190 200 210 pF1KB6 LKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV : .:: ...... : ::::.: .. : ::....:.. . ... :::.: XP_016 TKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHV 220 230 240 250 260 270 220 pF1KB6 A-KGGLGLILKRMVEG : : : . ..: ... XP_016 ASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNG 280 290 300 310 320 330 >>XP_016871635 (OMIM: 600465,615493) PREDICTED: ankyrin- (1737 aa) initn: 1994 init1: 395 opt: 401 Z-score: 317.3 bits: 68.9 E(85289): 6.2e-11 Smith-Waterman score: 401; 39.2% identity (69.9% similar) in 176 aa overlap (36-211:561-736) 10 20 30 40 50 60 pF1KB6 SNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVP : . . : :: : . :. :....::: .. XP_016 SGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSAS 540 550 560 570 580 590 70 80 90 100 110 120 pF1KB6 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML . .: .:::.:: .... :: .::. .:. .:: :::: ::.::. .::. : XP_016 PDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTL 600 610 620 630 640 650 130 140 150 160 170 180 pF1KB6 LEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV :: ::. .: . ...: :: .:.. :. .:: .:..:... : :::::: .:.:: XP_016 LEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRV 660 670 680 690 700 710 190 200 210 220 pF1KB6 EEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG . :..::.::: . ..: :::.: XP_016 NVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQA 720 730 740 750 760 770 >-- initn: 1134 init1: 364 opt: 383 Z-score: 303.9 bits: 66.4 E(85289): 3.4e-10 Smith-Waterman score: 383; 33.3% identity (65.7% similar) in 216 aa overlap (11-225:307-520) 10 20 30 40 pF1KB6 MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDS :. : ::. :.. : .: . ... XP_016 KRGNANMVKLLLDRGAKIDAKTRDGLTPLHCG-ARSGH-EQVVEMLLDRAAPILSKTKNG 280 290 300 310 320 330 50 60 70 80 90 100 pF1KB6 RTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN . :: : .. : . :..::: .:::.: . . ::.:: :. ...:.:: : :. : XP_016 LSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPN 340 350 360 370 380 390 110 120 130 140 150 160 pF1KB6 AVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLY : :: :::: : .::: .. .::. ::. .: . : .: :: :..... :.. XP_016 AKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMH 400 410 420 430 440 450 170 180 190 200 210 pF1KB6 YKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV-AKGGLGLI . :: : ...:.: ::.: ..: .. ::..::.. . :...:::.. :. : . : XP_016 HGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADI 460 470 480 490 500 510 220 pF1KB6 LKRMVEG ...... XP_016 VQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAK 520 530 540 550 560 570 >-- initn: 427 init1: 266 opt: 319 Z-score: 256.3 bits: 57.6 E(85289): 1.6e-07 Smith-Waterman score: 332; 31.1% identity (66.7% similar) in 225 aa overlap (4-225:70-289) 10 20 30 pF1KB6 MEGCVSN-LMVCNLAYS-GKLEELKESILADKS : .: : . .:: . :..: ..: . . . XP_016 DANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREAN 40 50 60 70 80 90 40 50 60 70 80 90 pF1KB6 LATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKA . . : . . :::: : ::..:.:. :. :. :: ... :..::..::. .. :.:: XP_016 VDAATKKGN-TALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKF 100 110 120 130 140 150 100 110 120 130 140 150 pF1KB6 LLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGN :: .::. . ....: ::: : .... ... .:::. :.: . . :.: :: : . XP_016 LLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN----DTKGKVRLPALHIAARKDD 160 170 180 190 200 210 160 170 180 190 200 210 pF1KB6 LKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV : .:: ...... : ::::.: .. : ::....:.. . ... :::.: XP_016 TKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHV 220 230 240 250 260 270 220 pF1KB6 A-KGGLGLILKRMVEG : : : . ..: ... XP_016 ASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNG 280 290 300 310 320 330 >>XP_016871634 (OMIM: 600465,615493) PREDICTED: ankyrin- (1738 aa) initn: 1994 init1: 395 opt: 401 Z-score: 317.3 bits: 68.9 E(85289): 6.2e-11 Smith-Waterman score: 401; 39.2% identity (69.9% similar) in 176 aa overlap (36-211:561-736) 10 20 30 40 50 60 pF1KB6 SNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVP : . . : :: : . :. :....::: .. XP_016 SGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSAS 540 550 560 570 580 590 70 80 90 100 110 120 pF1KB6 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML . .: .:::.:: .... :: .::. .:. .:: :::: ::.::. .::. : XP_016 PDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTL 600 610 620 630 640 650 130 140 150 160 170 180 pF1KB6 LEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV :: ::. .: . ...: :: .:.. :. .:: .:..:... : :::::: .:.:: XP_016 LEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRV 660 670 680 690 700 710 190 200 210 220 pF1KB6 EEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG . :..::.::: . ..: :::.: XP_016 NVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQA 720 730 740 750 760 770 >-- initn: 1134 init1: 364 opt: 383 Z-score: 303.9 bits: 66.4 E(85289): 3.4e-10 Smith-Waterman score: 383; 33.3% identity (65.7% similar) in 216 aa overlap (11-225:307-520) 10 20 30 40 pF1KB6 MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDS :. : ::. :.. : .: . ... XP_016 KRGNANMVKLLLDRGAKIDAKTRDGLTPLHCG-ARSGH-EQVVEMLLDRAAPILSKTKNG 280 290 300 310 320 330 50 60 70 80 90 100 pF1KB6 RTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN . :: : .. : . :..::: .:::.: . . ::.:: :. ...:.:: : :. : XP_016 LSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPN 340 350 360 370 380 390 110 120 130 140 150 160 pF1KB6 AVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLY : :: :::: : .::: .. .::. ::. .: . : .: :: :..... :.. XP_016 AKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMH 400 410 420 430 440 450 170 180 190 200 210 pF1KB6 YKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV-AKGGLGLI . :: : ...:.: ::.: ..: .. ::..::.. . :...:::.. :. : . : XP_016 HGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADI 460 470 480 490 500 510 220 pF1KB6 LKRMVEG ...... XP_016 VQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAK 520 530 540 550 560 570 >-- initn: 427 init1: 266 opt: 319 Z-score: 256.3 bits: 57.6 E(85289): 1.6e-07 Smith-Waterman score: 332; 31.1% identity (66.7% similar) in 225 aa overlap (4-225:70-289) 10 20 30 pF1KB6 MEGCVSN-LMVCNLAYS-GKLEELKESILADKS : .: : . .:: . :..: ..: . . . XP_016 DANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREAN 40 50 60 70 80 90 40 50 60 70 80 90 pF1KB6 LATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKA . . : . . :::: : ::..:.:. :. :. :: ... :..::..::. .. :.:: XP_016 VDAATKKGN-TALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKF 100 110 120 130 140 150 100 110 120 130 140 150 pF1KB6 LLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGN :: .::. . ....: ::: : .... ... .:::. :.: . . :.: :: : . XP_016 LLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN----DTKGKVRLPALHIAARKDD 160 170 180 190 200 210 160 170 180 190 200 210 pF1KB6 LKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV : .:: ...... : ::::.: .. : ::....:.. . ... :::.: XP_016 TKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHV 220 230 240 250 260 270 220 pF1KB6 A-KGGLGLILKRMVEG : : : . ..: ... XP_016 ASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNG 280 290 300 310 320 330 >>XP_016871633 (OMIM: 600465,615493) PREDICTED: ankyrin- (1741 aa) initn: 1994 init1: 395 opt: 401 Z-score: 317.3 bits: 68.9 E(85289): 6.2e-11 Smith-Waterman score: 401; 39.2% identity (69.9% similar) in 176 aa overlap (36-211:561-736) 10 20 30 40 50 60 pF1KB6 SNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVP : . . : :: : . :. :....::: .. XP_016 SGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSAS 540 550 560 570 580 590 70 80 90 100 110 120 pF1KB6 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML . .: .:::.:: .... :: .::. .:. .:: :::: ::.::. .::. : XP_016 PDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTL 600 610 620 630 640 650 130 140 150 160 170 180 pF1KB6 LEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV :: ::. .: . ...: :: .:.. :. .:: .:..:... : :::::: .:.:: XP_016 LEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRV 660 670 680 690 700 710 190 200 210 220 pF1KB6 EEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG . :..::.::: . ..: :::.: XP_016 NVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQA 720 730 740 750 760 770 >-- initn: 1134 init1: 364 opt: 383 Z-score: 303.9 bits: 66.4 E(85289): 3.4e-10 Smith-Waterman score: 383; 33.3% identity (65.7% similar) in 216 aa overlap (11-225:307-520) 10 20 30 40 pF1KB6 MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDS :. : ::. :.. : .: . ... XP_016 KRGNANMVKLLLDRGAKIDAKTRDGLTPLHCG-ARSGH-EQVVEMLLDRAAPILSKTKNG 280 290 300 310 320 330 50 60 70 80 90 100 pF1KB6 RTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN . :: : .. : . :..::: .:::.: . . ::.:: :. ...:.:: : :. : XP_016 LSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPN 340 350 360 370 380 390 110 120 130 140 150 160 pF1KB6 AVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLY : :: :::: : .::: .. .::. ::. .: . : .: :: :..... :.. XP_016 AKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMH 400 410 420 430 440 450 170 180 190 200 210 pF1KB6 YKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV-AKGGLGLI . :: : ...:.: ::.: ..: .. ::..::.. . :...:::.. :. : . : XP_016 HGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADI 460 470 480 490 500 510 220 pF1KB6 LKRMVEG ...... XP_016 VQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAK 520 530 540 550 560 570 >-- initn: 427 init1: 266 opt: 319 Z-score: 256.2 bits: 57.6 E(85289): 1.6e-07 Smith-Waterman score: 332; 31.1% identity (66.7% similar) in 225 aa overlap (4-225:70-289) 10 20 30 pF1KB6 MEGCVSN-LMVCNLAYS-GKLEELKESILADKS : .: : . .:: . :..: ..: . . . XP_016 DANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREAN 40 50 60 70 80 90 40 50 60 70 80 90 pF1KB6 LATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKA . . : . . :::: : ::..:.:. :. :. :: ... :..::..::. .. :.:: XP_016 VDAATKKGN-TALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKF 100 110 120 130 140 150 100 110 120 130 140 150 pF1KB6 LLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGN :: .::. . ....: ::: : .... ... .:::. :.: . . :.: :: : . XP_016 LLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN----DTKGKVRLPALHIAARKDD 160 170 180 190 200 210 160 170 180 190 200 210 pF1KB6 LKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV : .:: ...... : ::::.: .. : ::....:.. . ... :::.: XP_016 TKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHV 220 230 240 250 260 270 220 pF1KB6 A-KGGLGLILKRMVEG : : : . ..: ... XP_016 ASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNG 280 290 300 310 320 330 >>XP_016871632 (OMIM: 600465,615493) PREDICTED: ankyrin- (1742 aa) initn: 1994 init1: 395 opt: 401 Z-score: 317.3 bits: 68.9 E(85289): 6.2e-11 Smith-Waterman score: 401; 39.2% identity (69.9% similar) in 176 aa overlap (36-211:561-736) 10 20 30 40 50 60 pF1KB6 SNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVP : . . : :: : . :. :....::: .. XP_016 SGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSAS 540 550 560 570 580 590 70 80 90 100 110 120 pF1KB6 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML . .: .:::.:: .... :: .::. .:. .:: :::: ::.::. .::. : XP_016 PDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTL 600 610 620 630 640 650 130 140 150 160 170 180 pF1KB6 LEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV :: ::. .: . ...: :: .:.. :. .:: .:..:... : :::::: .:.:: XP_016 LEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRV 660 670 680 690 700 710 190 200 210 220 pF1KB6 EEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG . :..::.::: . ..: :::.: XP_016 NVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQA 720 730 740 750 760 770 >-- initn: 1134 init1: 364 opt: 383 Z-score: 303.9 bits: 66.4 E(85289): 3.4e-10 Smith-Waterman score: 383; 33.3% identity (65.7% similar) in 216 aa overlap (11-225:307-520) 10 20 30 40 pF1KB6 MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDS :. : ::. :.. : .: . ... XP_016 KRGNANMVKLLLDRGAKIDAKTRDGLTPLHCG-ARSGH-EQVVEMLLDRAAPILSKTKNG 280 290 300 310 320 330 50 60 70 80 90 100 pF1KB6 RTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN . :: : .. : . :..::: .:::.: . . ::.:: :. ...:.:: : :. : XP_016 LSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPN 340 350 360 370 380 390 110 120 130 140 150 160 pF1KB6 AVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLY : :: :::: : .::: .. .::. ::. .: . : .: :: :..... :.. XP_016 AKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMH 400 410 420 430 440 450 170 180 190 200 210 pF1KB6 YKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV-AKGGLGLI . :: : ...:.: ::.: ..: .. ::..::.. . :...:::.. :. : . : XP_016 HGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADI 460 470 480 490 500 510 220 pF1KB6 LKRMVEG ...... XP_016 VQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAK 520 530 540 550 560 570 >-- initn: 427 init1: 266 opt: 319 Z-score: 256.2 bits: 57.6 E(85289): 1.6e-07 Smith-Waterman score: 332; 31.1% identity (66.7% similar) in 225 aa overlap (4-225:70-289) 10 20 30 pF1KB6 MEGCVSN-LMVCNLAYS-GKLEELKESILADKS : .: : . .:: . :..: ..: . . . XP_016 DANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREAN 40 50 60 70 80 90 40 50 60 70 80 90 pF1KB6 LATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKA . . : . . :::: : ::..:.:. :. :. :: ... :..::..::. .. :.:: XP_016 VDAATKKGN-TALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKF 100 110 120 130 140 150 100 110 120 130 140 150 pF1KB6 LLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGN :: .::. . ....: ::: : .... ... .:::. :.: . . :.: :: : . XP_016 LLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN----DTKGKVRLPALHIAARKDD 160 170 180 190 200 210 160 170 180 190 200 210 pF1KB6 LKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV : .:: ...... : ::::.: .. : ::....:.. . ... :::.: XP_016 TKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHV 220 230 240 250 260 270 220 pF1KB6 A-KGGLGLILKRMVEG : : : . ..: ... XP_016 ASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNG 280 290 300 310 320 330 >>XP_016871631 (OMIM: 600465,615493) PREDICTED: ankyrin- (1747 aa) initn: 1994 init1: 395 opt: 401 Z-score: 317.3 bits: 68.9 E(85289): 6.2e-11 Smith-Waterman score: 401; 39.2% identity (69.9% similar) in 176 aa overlap (36-211:561-736) 10 20 30 40 50 60 pF1KB6 SNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVP : . . : :: : . :. :....::: .. XP_016 SGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSAS 540 550 560 570 580 590 70 80 90 100 110 120 pF1KB6 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML . .: .:::.:: .... :: .::. .:. .:: :::: ::.::. .::. : XP_016 PDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTL 600 610 620 630 640 650 130 140 150 160 170 180 pF1KB6 LEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV :: ::. .: . ...: :: .:.. :. .:: .:..:... : :::::: .:.:: XP_016 LEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRV 660 670 680 690 700 710 190 200 210 220 pF1KB6 EEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG . :..::.::: . ..: :::.: XP_016 NVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQA 720 730 740 750 760 770 >-- initn: 1134 init1: 364 opt: 383 Z-score: 303.9 bits: 66.4 E(85289): 3.5e-10 Smith-Waterman score: 383; 33.3% identity (65.7% similar) in 216 aa overlap (11-225:307-520) 10 20 30 40 pF1KB6 MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDS :. : ::. :.. : .: . ... XP_016 KRGNANMVKLLLDRGAKIDAKTRDGLTPLHCG-ARSGH-EQVVEMLLDRAAPILSKTKNG 280 290 300 310 320 330 50 60 70 80 90 100 pF1KB6 RTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN . :: : .. : . :..::: .:::.: . . ::.:: :. ...:.:: : :. : XP_016 LSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPN 340 350 360 370 380 390 110 120 130 140 150 160 pF1KB6 AVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLY : :: :::: : .::: .. .::. ::. .: . : .: :: :..... :.. XP_016 AKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMH 400 410 420 430 440 450 170 180 190 200 210 pF1KB6 YKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV-AKGGLGLI . :: : ...:.: ::.: ..: .. ::..::.. . :...:::.. :. : . : XP_016 HGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADI 460 470 480 490 500 510 220 pF1KB6 LKRMVEG ...... XP_016 VQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAK 520 530 540 550 560 570 >-- initn: 427 init1: 266 opt: 319 Z-score: 256.2 bits: 57.6 E(85289): 1.6e-07 Smith-Waterman score: 332; 31.1% identity (66.7% similar) in 225 aa overlap (4-225:70-289) 10 20 30 pF1KB6 MEGCVSN-LMVCNLAYS-GKLEELKESILADKS : .: : . .:: . :..: ..: . . . XP_016 DANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREAN 40 50 60 70 80 90 40 50 60 70 80 90 pF1KB6 LATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKA . . : . . :::: : ::..:.:. :. :. :: ... :..::..::. .. :.:: XP_016 VDAATKKGN-TALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKF 100 110 120 130 140 150 100 110 120 130 140 150 pF1KB6 LLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGN :: .::. . ....: ::: : .... ... .:::. :.: . . :.: :: : . XP_016 LLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN----DTKGKVRLPALHIAARKDD 160 170 180 190 200 210 160 170 180 190 200 210 pF1KB6 LKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV : .:: ...... : ::::.: .. : ::....:.. . ... :::.: XP_016 TKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHV 220 230 240 250 260 270 220 pF1KB6 A-KGGLGLILKRMVEG : : : . ..: ... XP_016 ASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNG 280 290 300 310 320 330 226 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 12:43:26 2016 done: Fri Nov 4 12:43:27 2016 Total Scan time: 6.240 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]