Result of FASTA (omim) for pF1KB6920
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB6920, 226 aa
  1>>>pF1KB6920 226 - 226 aa - 226 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 7.2869+/-0.000555; mu= 2.1629+/- 0.033
 mean_var=180.2803+/-42.547, 0's: 0 Z-trim(112.5): 823  B-trim: 407 in 1/48
 Lambda= 0.095521
 statistics sampled from 20359 (21415) to 20359 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.622), E-opt: 0.2 (0.251), width:  16
 Scan time:  6.240

The best scores are:                                      opt bits E(85289)
NP_002805 (OMIM: 300880) 26S proteasome non-ATPase ( 226) 1472 215.6 5.5e-56
NP_736606 (OMIM: 300880) 26S proteasome non-ATPase ( 151)  985 148.3 6.7e-36
XP_016871638 (OMIM: 600465,615493) PREDICTED: anky (1720)  401 68.9 6.1e-11
XP_016871637 (OMIM: 600465,615493) PREDICTED: anky (1725)  401 68.9 6.1e-11
XP_016871636 (OMIM: 600465,615493) PREDICTED: anky (1735)  401 68.9 6.2e-11
XP_016871635 (OMIM: 600465,615493) PREDICTED: anky (1737)  401 68.9 6.2e-11
XP_016871634 (OMIM: 600465,615493) PREDICTED: anky (1738)  401 68.9 6.2e-11
XP_016871633 (OMIM: 600465,615493) PREDICTED: anky (1741)  401 68.9 6.2e-11
XP_016871632 (OMIM: 600465,615493) PREDICTED: anky (1742)  401 68.9 6.2e-11
XP_016871631 (OMIM: 600465,615493) PREDICTED: anky (1747)  401 68.9 6.2e-11
XP_016871630 (OMIM: 600465,615493) PREDICTED: anky (1751)  401 68.9 6.2e-11
XP_016871629 (OMIM: 600465,615493) PREDICTED: anky (1763)  401 68.9 6.2e-11
XP_016871628 (OMIM: 600465,615493) PREDICTED: anky (1764)  401 68.9 6.2e-11
XP_016871627 (OMIM: 600465,615493) PREDICTED: anky (1785)  401 68.9 6.3e-11
XP_016871626 (OMIM: 600465,615493) PREDICTED: anky (1786)  401 68.9 6.3e-11
XP_016871625 (OMIM: 600465,615493) PREDICTED: anky (1795)  401 68.9 6.3e-11
XP_016871624 (OMIM: 600465,615493) PREDICTED: anky (1838)  401 68.9 6.4e-11
XP_016871623 (OMIM: 600465,615493) PREDICTED: anky (1845)  401 68.9 6.4e-11
XP_016871622 (OMIM: 600465,615493) PREDICTED: anky (1850)  401 68.9 6.4e-11
XP_016871621 (OMIM: 600465,615493) PREDICTED: anky (1855)  401 68.9 6.4e-11
NP_001191332 (OMIM: 600465,615493) ankyrin-3 isofo (1861)  401 68.9 6.5e-11
XP_016871620 (OMIM: 600465,615493) PREDICTED: anky (1862)  401 68.9 6.5e-11
XP_016871619 (OMIM: 600465,615493) PREDICTED: anky (1866)  401 68.9 6.5e-11
NP_001307803 (OMIM: 600465,615493) ankyrin-3 isofo (1867)  401 68.9 6.5e-11
NP_001191333 (OMIM: 600465,615493) ankyrin-3 isofo (1868)  401 68.9 6.5e-11
XP_005269772 (OMIM: 600465,615493) PREDICTED: anky (1885)  401 68.9 6.5e-11
XP_016871618 (OMIM: 600465,615493) PREDICTED: anky (1888)  401 68.9 6.5e-11
XP_016871617 (OMIM: 600465,615493) PREDICTED: anky (1889)  401 68.9 6.5e-11
XP_006717865 (OMIM: 600465,615493) PREDICTED: anky (1898)  401 68.9 6.6e-11
XP_016871616 (OMIM: 600465,615493) PREDICTED: anky (2603)  401 69.1 8.2e-11
XP_016871615 (OMIM: 600465,615493) PREDICTED: anky (2612)  401 69.1 8.2e-11
XP_016871614 (OMIM: 600465,615493) PREDICTED: anky (2646)  401 69.1 8.3e-11
XP_016871613 (OMIM: 600465,615493) PREDICTED: anky (2647)  401 69.1 8.3e-11
XP_016871612 (OMIM: 600465,615493) PREDICTED: anky (2655)  401 69.1 8.3e-11
XP_011538011 (OMIM: 600465,615493) PREDICTED: anky (2656)  401 69.1 8.3e-11
XP_016871611 (OMIM: 600465,615493) PREDICTED: anky (2728)  401 69.1 8.4e-11
XP_006717859 (OMIM: 600465,615493) PREDICTED: anky (2758)  401 69.1 8.5e-11
XP_011538010 (OMIM: 600465,615493) PREDICTED: anky (2759)  401 69.1 8.5e-11
XP_016871610 (OMIM: 600465,615493) PREDICTED: anky (3945)  401 69.2 1.1e-10
XP_016871609 (OMIM: 600465,615493) PREDICTED: anky (3953)  401 69.2 1.1e-10
XP_016871608 (OMIM: 600465,615493) PREDICTED: anky (3954)  401 69.2 1.1e-10
XP_016871607 (OMIM: 600465,615493) PREDICTED: anky (4057)  401 69.3 1.1e-10
NP_066267 (OMIM: 600465,615493) ankyrin-3 isoform  (4377)  401 69.3 1.2e-10
XP_016871639 (OMIM: 600465,615493) PREDICTED: anky (4379)  401 69.3 1.2e-10
XP_016871606 (OMIM: 600465,615493) PREDICTED: anky (4400)  401 69.3 1.2e-10
XP_016871605 (OMIM: 600465,615493) PREDICTED: anky (4401)  401 69.3 1.2e-10
XP_016871604 (OMIM: 600465,615493) PREDICTED: anky (4478)  401 69.3 1.2e-10
XP_016871603 (OMIM: 600465,615493) PREDICTED: anky (4487)  401 69.3 1.2e-10
XP_016871602 (OMIM: 600465,615493) PREDICTED: anky (4495)  401 69.3 1.2e-10
XP_016871601 (OMIM: 600465,615493) PREDICTED: anky (4499)  401 69.3 1.2e-10


>>NP_002805 (OMIM: 300880) 26S proteasome non-ATPase reg  (226 aa)
 initn: 1472 init1: 1472 opt: 1472  Z-score: 1126.1  bits: 215.6 E(85289): 5.5e-56
Smith-Waterman score: 1472; 100.0% identity (100.0% similar) in 226 aa overlap (1-226:1-226)

               10        20        30        40        50        60
pF1KB6 MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB6 IAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLAC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 IAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLAC
              130       140       150       160       170       180

              190       200       210       220      
pF1KB6 DEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG
       ::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG
              190       200       210       220      

>>NP_736606 (OMIM: 300880) 26S proteasome non-ATPase reg  (151 aa)
 initn: 985 init1: 985 opt: 985  Z-score: 765.5  bits: 148.3 E(85289): 6.7e-36
Smith-Waterman score: 985; 100.0% identity (100.0% similar) in 149 aa overlap (1-149:1-149)

               10        20        30        40        50        60
pF1KB6 MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_736 MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_736 QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB6 IAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLAC
       :::::::::::::::::::::::::::::                               
NP_736 IAVMLLEGGANPDAKDHYEATAMHRAAAKDT                             
              130       140       150                              

>>XP_016871638 (OMIM: 600465,615493) PREDICTED: ankyrin-  (1720 aa)
 initn: 1994 init1: 395 opt: 401  Z-score: 317.4  bits: 68.9 E(85289): 6.1e-11
Smith-Waterman score: 401; 39.2% identity (69.9% similar) in 176 aa overlap (36-211:544-719)

          10        20        30        40        50        60     
pF1KB6 SNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVP
                                     : . . : :: : . :. :....::: .. 
XP_016 SGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSAS
           520       530       540       550       560       570   

          70        80        90       100       110       120     
pF1KB6 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML
        .    .: .:::.::    ....  :: .::. .:. .:: :::: ::.::. .::. :
XP_016 PDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTL
           580       590       600       610       620       630   

         130       140       150       160       170       180     
pF1KB6 LEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV
       :: ::. .:  .   ...: :: .:.. :. .::  .:..:...  : :::::: .:.::
XP_016 LEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRV
           640       650       660       670       680       690   

         190       200       210       220                         
pF1KB6 EEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG                   
       . :..::.::: .  ..:   :::.:                                  
XP_016 NVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQA
           700       710       720       730       740       750   

>--
 initn: 1134 init1: 364 opt: 383  Z-score: 304.0  bits: 66.4 E(85289): 3.4e-10
Smith-Waterman score: 383; 33.3% identity (65.7% similar) in 216 aa overlap (11-225:290-503)

                                   10        20        30        40
pF1KB6                     MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDS
                                     :. : ::. :.. : .:   .      ...
XP_016 KRGNANMVKLLLDRGAKIDAKTRDGLTPLHCG-ARSGH-EQVVEMLLDRAAPILSKTKNG
     260       270       280       290         300       310       

               50        60        70        80        90       100
pF1KB6 RTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN
        . :: : .. : . :..::: .:::.:  .   . ::.::  :. ...:.:: : :. :
XP_016 LSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPN
       320       330       340       350       360       370       

              110       120       130       140       150       160
pF1KB6 AVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLY
       :   :: :::: : .::: ..  .::. ::. .:  .   : .: ::  :.....  :..
XP_016 AKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMH
       380       390       400       410       420       430       

              170       180       190       200       210          
pF1KB6 YKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV-AKGGLGLI
       . :: :  ...:.: ::.:    ..: .. ::..::..  . :...:::.. :. : . :
XP_016 HGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADI
       440       450       460       470       480       490       

     220                                                           
pF1KB6 LKRMVEG                                                     
       ......                                                      
XP_016 VQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAK
       500       510       520       530       540       550       

>--
 initn: 427 init1: 266 opt: 319  Z-score: 256.3  bits: 57.6 E(85289): 1.5e-07
Smith-Waterman score: 332; 31.1% identity (66.7% similar) in 225 aa overlap (4-225:53-272)

                                           10         20        30 
pF1KB6                            MEGCVSN-LMVCNLAYS-GKLEELKESILADKS
                                     : .: : . .:: . :..: ..: .  . .
XP_016 DANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREAN
             30        40        50        60        70        80  

              40        50        60        70        80        90 
pF1KB6 LATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKA
       . . : . . :::: :  ::..:.:. :.  :. :: ... :..::..::. .. :.:: 
XP_016 VDAATKKGN-TALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKF
             90        100       110       120       130       140 

             100       110       120       130       140       150 
pF1KB6 LLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGN
       :: .::. . ....: :::  : .... ... .:::.    :.: . .  :.: :: : .
XP_016 LLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN----DTKGKVRLPALHIAARKDD
             150       160       170           180       190       

             160       170       180       190       200       210 
pF1KB6 LKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV
        :   .::    ......  : ::::.:     .. : ::....:.. .  ... :::.:
XP_016 TKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHV
       200       210       220       230       240       250       

              220                                                  
pF1KB6 A-KGGLGLILKRMVEG                                            
       : : : . ..: ...                                             
XP_016 ASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNG
       260       270       280       290       300       310       

>>XP_016871637 (OMIM: 600465,615493) PREDICTED: ankyrin-  (1725 aa)
 initn: 1994 init1: 395 opt: 401  Z-score: 317.4  bits: 68.9 E(85289): 6.1e-11
Smith-Waterman score: 401; 39.2% identity (69.9% similar) in 176 aa overlap (36-211:544-719)

          10        20        30        40        50        60     
pF1KB6 SNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVP
                                     : . . : :: : . :. :....::: .. 
XP_016 SGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSAS
           520       530       540       550       560       570   

          70        80        90       100       110       120     
pF1KB6 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML
        .    .: .:::.::    ....  :: .::. .:. .:: :::: ::.::. .::. :
XP_016 PDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTL
           580       590       600       610       620       630   

         130       140       150       160       170       180     
pF1KB6 LEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV
       :: ::. .:  .   ...: :: .:.. :. .::  .:..:...  : :::::: .:.::
XP_016 LEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRV
           640       650       660       670       680       690   

         190       200       210       220                         
pF1KB6 EEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG                   
       . :..::.::: .  ..:   :::.:                                  
XP_016 NVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQA
           700       710       720       730       740       750   

>--
 initn: 1134 init1: 364 opt: 383  Z-score: 304.0  bits: 66.4 E(85289): 3.4e-10
Smith-Waterman score: 383; 33.3% identity (65.7% similar) in 216 aa overlap (11-225:290-503)

                                   10        20        30        40
pF1KB6                     MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDS
                                     :. : ::. :.. : .:   .      ...
XP_016 KRGNANMVKLLLDRGAKIDAKTRDGLTPLHCG-ARSGH-EQVVEMLLDRAAPILSKTKNG
     260       270       280       290         300       310       

               50        60        70        80        90       100
pF1KB6 RTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN
        . :: : .. : . :..::: .:::.:  .   . ::.::  :. ...:.:: : :. :
XP_016 LSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPN
       320       330       340       350       360       370       

              110       120       130       140       150       160
pF1KB6 AVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLY
       :   :: :::: : .::: ..  .::. ::. .:  .   : .: ::  :.....  :..
XP_016 AKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMH
       380       390       400       410       420       430       

              170       180       190       200       210          
pF1KB6 YKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV-AKGGLGLI
       . :: :  ...:.: ::.:    ..: .. ::..::..  . :...:::.. :. : . :
XP_016 HGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADI
       440       450       460       470       480       490       

     220                                                           
pF1KB6 LKRMVEG                                                     
       ......                                                      
XP_016 VQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAK
       500       510       520       530       540       550       

>--
 initn: 427 init1: 266 opt: 319  Z-score: 256.3  bits: 57.6 E(85289): 1.5e-07
Smith-Waterman score: 332; 31.1% identity (66.7% similar) in 225 aa overlap (4-225:53-272)

                                           10         20        30 
pF1KB6                            MEGCVSN-LMVCNLAYS-GKLEELKESILADKS
                                     : .: : . .:: . :..: ..: .  . .
XP_016 DANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREAN
             30        40        50        60        70        80  

              40        50        60        70        80        90 
pF1KB6 LATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKA
       . . : . . :::: :  ::..:.:. :.  :. :: ... :..::..::. .. :.:: 
XP_016 VDAATKKGN-TALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKF
             90        100       110       120       130       140 

             100       110       120       130       140       150 
pF1KB6 LLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGN
       :: .::. . ....: :::  : .... ... .:::.    :.: . .  :.: :: : .
XP_016 LLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN----DTKGKVRLPALHIAARKDD
             150       160       170           180       190       

             160       170       180       190       200       210 
pF1KB6 LKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV
        :   .::    ......  : ::::.:     .. : ::....:.. .  ... :::.:
XP_016 TKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHV
       200       210       220       230       240       250       

              220                                                  
pF1KB6 A-KGGLGLILKRMVEG                                            
       : : : . ..: ...                                             
XP_016 ASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNG
       260       270       280       290       300       310       

>>XP_016871636 (OMIM: 600465,615493) PREDICTED: ankyrin-  (1735 aa)
 initn: 1994 init1: 395 opt: 401  Z-score: 317.3  bits: 68.9 E(85289): 6.2e-11
Smith-Waterman score: 401; 39.2% identity (69.9% similar) in 176 aa overlap (36-211:561-736)

          10        20        30        40        50        60     
pF1KB6 SNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVP
                                     : . . : :: : . :. :....::: .. 
XP_016 SGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSAS
              540       550       560       570       580       590

          70        80        90       100       110       120     
pF1KB6 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML
        .    .: .:::.::    ....  :: .::. .:. .:: :::: ::.::. .::. :
XP_016 PDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTL
              600       610       620       630       640       650

         130       140       150       160       170       180     
pF1KB6 LEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV
       :: ::. .:  .   ...: :: .:.. :. .::  .:..:...  : :::::: .:.::
XP_016 LEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRV
              660       670       680       690       700       710

         190       200       210       220                         
pF1KB6 EEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG                   
       . :..::.::: .  ..:   :::.:                                  
XP_016 NVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQA
              720       730       740       750       760       770

>--
 initn: 1134 init1: 364 opt: 383  Z-score: 303.9  bits: 66.4 E(85289): 3.4e-10
Smith-Waterman score: 383; 33.3% identity (65.7% similar) in 216 aa overlap (11-225:307-520)

                                   10        20        30        40
pF1KB6                     MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDS
                                     :. : ::. :.. : .:   .      ...
XP_016 KRGNANMVKLLLDRGAKIDAKTRDGLTPLHCG-ARSGH-EQVVEMLLDRAAPILSKTKNG
        280       290       300        310        320       330    

               50        60        70        80        90       100
pF1KB6 RTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN
        . :: : .. : . :..::: .:::.:  .   . ::.::  :. ...:.:: : :. :
XP_016 LSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPN
          340       350       360       370       380       390    

              110       120       130       140       150       160
pF1KB6 AVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLY
       :   :: :::: : .::: ..  .::. ::. .:  .   : .: ::  :.....  :..
XP_016 AKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMH
          400       410       420       430       440       450    

              170       180       190       200       210          
pF1KB6 YKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV-AKGGLGLI
       . :: :  ...:.: ::.:    ..: .. ::..::..  . :...:::.. :. : . :
XP_016 HGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADI
          460       470       480       490       500       510    

     220                                                           
pF1KB6 LKRMVEG                                                     
       ......                                                      
XP_016 VQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAK
          520       530       540       550       560       570    

>--
 initn: 427 init1: 266 opt: 319  Z-score: 256.3  bits: 57.6 E(85289): 1.6e-07
Smith-Waterman score: 332; 31.1% identity (66.7% similar) in 225 aa overlap (4-225:70-289)

                                           10         20        30 
pF1KB6                            MEGCVSN-LMVCNLAYS-GKLEELKESILADKS
                                     : .: : . .:: . :..: ..: .  . .
XP_016 DANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREAN
      40        50        60        70        80        90         

              40        50        60        70        80        90 
pF1KB6 LATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKA
       . . : . . :::: :  ::..:.:. :.  :. :: ... :..::..::. .. :.:: 
XP_016 VDAATKKGN-TALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKF
     100        110       120       130       140       150        

             100       110       120       130       140       150 
pF1KB6 LLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGN
       :: .::. . ....: :::  : .... ... .:::.    :.: . .  :.: :: : .
XP_016 LLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN----DTKGKVRLPALHIAARKDD
      160       170       180       190           200       210    

             160       170       180       190       200       210 
pF1KB6 LKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV
        :   .::    ......  : ::::.:     .. : ::....:.. .  ... :::.:
XP_016 TKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHV
          220       230       240       250       260       270    

              220                                                  
pF1KB6 A-KGGLGLILKRMVEG                                            
       : : : . ..: ...                                             
XP_016 ASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNG
          280       290       300       310       320       330    

>>XP_016871635 (OMIM: 600465,615493) PREDICTED: ankyrin-  (1737 aa)
 initn: 1994 init1: 395 opt: 401  Z-score: 317.3  bits: 68.9 E(85289): 6.2e-11
Smith-Waterman score: 401; 39.2% identity (69.9% similar) in 176 aa overlap (36-211:561-736)

          10        20        30        40        50        60     
pF1KB6 SNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVP
                                     : . . : :: : . :. :....::: .. 
XP_016 SGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSAS
              540       550       560       570       580       590

          70        80        90       100       110       120     
pF1KB6 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML
        .    .: .:::.::    ....  :: .::. .:. .:: :::: ::.::. .::. :
XP_016 PDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTL
              600       610       620       630       640       650

         130       140       150       160       170       180     
pF1KB6 LEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV
       :: ::. .:  .   ...: :: .:.. :. .::  .:..:...  : :::::: .:.::
XP_016 LEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRV
              660       670       680       690       700       710

         190       200       210       220                         
pF1KB6 EEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG                   
       . :..::.::: .  ..:   :::.:                                  
XP_016 NVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQA
              720       730       740       750       760       770

>--
 initn: 1134 init1: 364 opt: 383  Z-score: 303.9  bits: 66.4 E(85289): 3.4e-10
Smith-Waterman score: 383; 33.3% identity (65.7% similar) in 216 aa overlap (11-225:307-520)

                                   10        20        30        40
pF1KB6                     MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDS
                                     :. : ::. :.. : .:   .      ...
XP_016 KRGNANMVKLLLDRGAKIDAKTRDGLTPLHCG-ARSGH-EQVVEMLLDRAAPILSKTKNG
        280       290       300        310        320       330    

               50        60        70        80        90       100
pF1KB6 RTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN
        . :: : .. : . :..::: .:::.:  .   . ::.::  :. ...:.:: : :. :
XP_016 LSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPN
          340       350       360       370       380       390    

              110       120       130       140       150       160
pF1KB6 AVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLY
       :   :: :::: : .::: ..  .::. ::. .:  .   : .: ::  :.....  :..
XP_016 AKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMH
          400       410       420       430       440       450    

              170       180       190       200       210          
pF1KB6 YKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV-AKGGLGLI
       . :: :  ...:.: ::.:    ..: .. ::..::..  . :...:::.. :. : . :
XP_016 HGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADI
          460       470       480       490       500       510    

     220                                                           
pF1KB6 LKRMVEG                                                     
       ......                                                      
XP_016 VQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAK
          520       530       540       550       560       570    

>--
 initn: 427 init1: 266 opt: 319  Z-score: 256.3  bits: 57.6 E(85289): 1.6e-07
Smith-Waterman score: 332; 31.1% identity (66.7% similar) in 225 aa overlap (4-225:70-289)

                                           10         20        30 
pF1KB6                            MEGCVSN-LMVCNLAYS-GKLEELKESILADKS
                                     : .: : . .:: . :..: ..: .  . .
XP_016 DANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREAN
      40        50        60        70        80        90         

              40        50        60        70        80        90 
pF1KB6 LATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKA
       . . : . . :::: :  ::..:.:. :.  :. :: ... :..::..::. .. :.:: 
XP_016 VDAATKKGN-TALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKF
     100        110       120       130       140       150        

             100       110       120       130       140       150 
pF1KB6 LLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGN
       :: .::. . ....: :::  : .... ... .:::.    :.: . .  :.: :: : .
XP_016 LLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN----DTKGKVRLPALHIAARKDD
      160       170       180       190           200       210    

             160       170       180       190       200       210 
pF1KB6 LKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV
        :   .::    ......  : ::::.:     .. : ::....:.. .  ... :::.:
XP_016 TKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHV
          220       230       240       250       260       270    

              220                                                  
pF1KB6 A-KGGLGLILKRMVEG                                            
       : : : . ..: ...                                             
XP_016 ASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNG
          280       290       300       310       320       330    

>>XP_016871634 (OMIM: 600465,615493) PREDICTED: ankyrin-  (1738 aa)
 initn: 1994 init1: 395 opt: 401  Z-score: 317.3  bits: 68.9 E(85289): 6.2e-11
Smith-Waterman score: 401; 39.2% identity (69.9% similar) in 176 aa overlap (36-211:561-736)

          10        20        30        40        50        60     
pF1KB6 SNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVP
                                     : . . : :: : . :. :....::: .. 
XP_016 SGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSAS
              540       550       560       570       580       590

          70        80        90       100       110       120     
pF1KB6 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML
        .    .: .:::.::    ....  :: .::. .:. .:: :::: ::.::. .::. :
XP_016 PDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTL
              600       610       620       630       640       650

         130       140       150       160       170       180     
pF1KB6 LEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV
       :: ::. .:  .   ...: :: .:.. :. .::  .:..:...  : :::::: .:.::
XP_016 LEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRV
              660       670       680       690       700       710

         190       200       210       220                         
pF1KB6 EEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG                   
       . :..::.::: .  ..:   :::.:                                  
XP_016 NVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQA
              720       730       740       750       760       770

>--
 initn: 1134 init1: 364 opt: 383  Z-score: 303.9  bits: 66.4 E(85289): 3.4e-10
Smith-Waterman score: 383; 33.3% identity (65.7% similar) in 216 aa overlap (11-225:307-520)

                                   10        20        30        40
pF1KB6                     MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDS
                                     :. : ::. :.. : .:   .      ...
XP_016 KRGNANMVKLLLDRGAKIDAKTRDGLTPLHCG-ARSGH-EQVVEMLLDRAAPILSKTKNG
        280       290       300        310        320       330    

               50        60        70        80        90       100
pF1KB6 RTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN
        . :: : .. : . :..::: .:::.:  .   . ::.::  :. ...:.:: : :. :
XP_016 LSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPN
          340       350       360       370       380       390    

              110       120       130       140       150       160
pF1KB6 AVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLY
       :   :: :::: : .::: ..  .::. ::. .:  .   : .: ::  :.....  :..
XP_016 AKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMH
          400       410       420       430       440       450    

              170       180       190       200       210          
pF1KB6 YKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV-AKGGLGLI
       . :: :  ...:.: ::.:    ..: .. ::..::..  . :...:::.. :. : . :
XP_016 HGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADI
          460       470       480       490       500       510    

     220                                                           
pF1KB6 LKRMVEG                                                     
       ......                                                      
XP_016 VQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAK
          520       530       540       550       560       570    

>--
 initn: 427 init1: 266 opt: 319  Z-score: 256.3  bits: 57.6 E(85289): 1.6e-07
Smith-Waterman score: 332; 31.1% identity (66.7% similar) in 225 aa overlap (4-225:70-289)

                                           10         20        30 
pF1KB6                            MEGCVSN-LMVCNLAYS-GKLEELKESILADKS
                                     : .: : . .:: . :..: ..: .  . .
XP_016 DANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREAN
      40        50        60        70        80        90         

              40        50        60        70        80        90 
pF1KB6 LATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKA
       . . : . . :::: :  ::..:.:. :.  :. :: ... :..::..::. .. :.:: 
XP_016 VDAATKKGN-TALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKF
     100        110       120       130       140       150        

             100       110       120       130       140       150 
pF1KB6 LLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGN
       :: .::. . ....: :::  : .... ... .:::.    :.: . .  :.: :: : .
XP_016 LLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN----DTKGKVRLPALHIAARKDD
      160       170       180       190           200       210    

             160       170       180       190       200       210 
pF1KB6 LKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV
        :   .::    ......  : ::::.:     .. : ::....:.. .  ... :::.:
XP_016 TKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHV
          220       230       240       250       260       270    

              220                                                  
pF1KB6 A-KGGLGLILKRMVEG                                            
       : : : . ..: ...                                             
XP_016 ASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNG
          280       290       300       310       320       330    

>>XP_016871633 (OMIM: 600465,615493) PREDICTED: ankyrin-  (1741 aa)
 initn: 1994 init1: 395 opt: 401  Z-score: 317.3  bits: 68.9 E(85289): 6.2e-11
Smith-Waterman score: 401; 39.2% identity (69.9% similar) in 176 aa overlap (36-211:561-736)

          10        20        30        40        50        60     
pF1KB6 SNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVP
                                     : . . : :: : . :. :....::: .. 
XP_016 SGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSAS
              540       550       560       570       580       590

          70        80        90       100       110       120     
pF1KB6 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML
        .    .: .:::.::    ....  :: .::. .:. .:: :::: ::.::. .::. :
XP_016 PDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTL
              600       610       620       630       640       650

         130       140       150       160       170       180     
pF1KB6 LEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV
       :: ::. .:  .   ...: :: .:.. :. .::  .:..:...  : :::::: .:.::
XP_016 LEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRV
              660       670       680       690       700       710

         190       200       210       220                         
pF1KB6 EEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG                   
       . :..::.::: .  ..:   :::.:                                  
XP_016 NVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQA
              720       730       740       750       760       770

>--
 initn: 1134 init1: 364 opt: 383  Z-score: 303.9  bits: 66.4 E(85289): 3.4e-10
Smith-Waterman score: 383; 33.3% identity (65.7% similar) in 216 aa overlap (11-225:307-520)

                                   10        20        30        40
pF1KB6                     MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDS
                                     :. : ::. :.. : .:   .      ...
XP_016 KRGNANMVKLLLDRGAKIDAKTRDGLTPLHCG-ARSGH-EQVVEMLLDRAAPILSKTKNG
        280       290       300        310        320       330    

               50        60        70        80        90       100
pF1KB6 RTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN
        . :: : .. : . :..::: .:::.:  .   . ::.::  :. ...:.:: : :. :
XP_016 LSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPN
          340       350       360       370       380       390    

              110       120       130       140       150       160
pF1KB6 AVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLY
       :   :: :::: : .::: ..  .::. ::. .:  .   : .: ::  :.....  :..
XP_016 AKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMH
          400       410       420       430       440       450    

              170       180       190       200       210          
pF1KB6 YKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV-AKGGLGLI
       . :: :  ...:.: ::.:    ..: .. ::..::..  . :...:::.. :. : . :
XP_016 HGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADI
          460       470       480       490       500       510    

     220                                                           
pF1KB6 LKRMVEG                                                     
       ......                                                      
XP_016 VQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAK
          520       530       540       550       560       570    

>--
 initn: 427 init1: 266 opt: 319  Z-score: 256.2  bits: 57.6 E(85289): 1.6e-07
Smith-Waterman score: 332; 31.1% identity (66.7% similar) in 225 aa overlap (4-225:70-289)

                                           10         20        30 
pF1KB6                            MEGCVSN-LMVCNLAYS-GKLEELKESILADKS
                                     : .: : . .:: . :..: ..: .  . .
XP_016 DANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREAN
      40        50        60        70        80        90         

              40        50        60        70        80        90 
pF1KB6 LATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKA
       . . : . . :::: :  ::..:.:. :.  :. :: ... :..::..::. .. :.:: 
XP_016 VDAATKKGN-TALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKF
     100        110       120       130       140       150        

             100       110       120       130       140       150 
pF1KB6 LLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGN
       :: .::. . ....: :::  : .... ... .:::.    :.: . .  :.: :: : .
XP_016 LLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN----DTKGKVRLPALHIAARKDD
      160       170       180       190           200       210    

             160       170       180       190       200       210 
pF1KB6 LKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV
        :   .::    ......  : ::::.:     .. : ::....:.. .  ... :::.:
XP_016 TKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHV
          220       230       240       250       260       270    

              220                                                  
pF1KB6 A-KGGLGLILKRMVEG                                            
       : : : . ..: ...                                             
XP_016 ASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNG
          280       290       300       310       320       330    

>>XP_016871632 (OMIM: 600465,615493) PREDICTED: ankyrin-  (1742 aa)
 initn: 1994 init1: 395 opt: 401  Z-score: 317.3  bits: 68.9 E(85289): 6.2e-11
Smith-Waterman score: 401; 39.2% identity (69.9% similar) in 176 aa overlap (36-211:561-736)

          10        20        30        40        50        60     
pF1KB6 SNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVP
                                     : . . : :: : . :. :....::: .. 
XP_016 SGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSAS
              540       550       560       570       580       590

          70        80        90       100       110       120     
pF1KB6 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML
        .    .: .:::.::    ....  :: .::. .:. .:: :::: ::.::. .::. :
XP_016 PDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTL
              600       610       620       630       640       650

         130       140       150       160       170       180     
pF1KB6 LEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV
       :: ::. .:  .   ...: :: .:.. :. .::  .:..:...  : :::::: .:.::
XP_016 LEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRV
              660       670       680       690       700       710

         190       200       210       220                         
pF1KB6 EEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG                   
       . :..::.::: .  ..:   :::.:                                  
XP_016 NVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQA
              720       730       740       750       760       770

>--
 initn: 1134 init1: 364 opt: 383  Z-score: 303.9  bits: 66.4 E(85289): 3.4e-10
Smith-Waterman score: 383; 33.3% identity (65.7% similar) in 216 aa overlap (11-225:307-520)

                                   10        20        30        40
pF1KB6                     MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDS
                                     :. : ::. :.. : .:   .      ...
XP_016 KRGNANMVKLLLDRGAKIDAKTRDGLTPLHCG-ARSGH-EQVVEMLLDRAAPILSKTKNG
        280       290       300        310        320       330    

               50        60        70        80        90       100
pF1KB6 RTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN
        . :: : .. : . :..::: .:::.:  .   . ::.::  :. ...:.:: : :. :
XP_016 LSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPN
          340       350       360       370       380       390    

              110       120       130       140       150       160
pF1KB6 AVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLY
       :   :: :::: : .::: ..  .::. ::. .:  .   : .: ::  :.....  :..
XP_016 AKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMH
          400       410       420       430       440       450    

              170       180       190       200       210          
pF1KB6 YKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV-AKGGLGLI
       . :: :  ...:.: ::.:    ..: .. ::..::..  . :...:::.. :. : . :
XP_016 HGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADI
          460       470       480       490       500       510    

     220                                                           
pF1KB6 LKRMVEG                                                     
       ......                                                      
XP_016 VQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAK
          520       530       540       550       560       570    

>--
 initn: 427 init1: 266 opt: 319  Z-score: 256.2  bits: 57.6 E(85289): 1.6e-07
Smith-Waterman score: 332; 31.1% identity (66.7% similar) in 225 aa overlap (4-225:70-289)

                                           10         20        30 
pF1KB6                            MEGCVSN-LMVCNLAYS-GKLEELKESILADKS
                                     : .: : . .:: . :..: ..: .  . .
XP_016 DANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREAN
      40        50        60        70        80        90         

              40        50        60        70        80        90 
pF1KB6 LATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKA
       . . : . . :::: :  ::..:.:. :.  :. :: ... :..::..::. .. :.:: 
XP_016 VDAATKKGN-TALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKF
     100        110       120       130       140       150        

             100       110       120       130       140       150 
pF1KB6 LLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGN
       :: .::. . ....: :::  : .... ... .:::.    :.: . .  :.: :: : .
XP_016 LLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN----DTKGKVRLPALHIAARKDD
      160       170       180       190           200       210    

             160       170       180       190       200       210 
pF1KB6 LKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV
        :   .::    ......  : ::::.:     .. : ::....:.. .  ... :::.:
XP_016 TKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHV
          220       230       240       250       260       270    

              220                                                  
pF1KB6 A-KGGLGLILKRMVEG                                            
       : : : . ..: ...                                             
XP_016 ASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNG
          280       290       300       310       320       330    

>>XP_016871631 (OMIM: 600465,615493) PREDICTED: ankyrin-  (1747 aa)
 initn: 1994 init1: 395 opt: 401  Z-score: 317.3  bits: 68.9 E(85289): 6.2e-11
Smith-Waterman score: 401; 39.2% identity (69.9% similar) in 176 aa overlap (36-211:561-736)

          10        20        30        40        50        60     
pF1KB6 SNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVP
                                     : . . : :: : . :. :....::: .. 
XP_016 SGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSAS
              540       550       560       570       580       590

          70        80        90       100       110       120     
pF1KB6 VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML
        .    .: .:::.::    ....  :: .::. .:. .:: :::: ::.::. .::. :
XP_016 PDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTL
              600       610       620       630       640       650

         130       140       150       160       170       180     
pF1KB6 LEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV
       :: ::. .:  .   ...: :: .:.. :. .::  .:..:...  : :::::: .:.::
XP_016 LEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRV
              660       670       680       690       700       710

         190       200       210       220                         
pF1KB6 EEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG                   
       . :..::.::: .  ..:   :::.:                                  
XP_016 NVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQA
              720       730       740       750       760       770

>--
 initn: 1134 init1: 364 opt: 383  Z-score: 303.9  bits: 66.4 E(85289): 3.5e-10
Smith-Waterman score: 383; 33.3% identity (65.7% similar) in 216 aa overlap (11-225:307-520)

                                   10        20        30        40
pF1KB6                     MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDS
                                     :. : ::. :.. : .:   .      ...
XP_016 KRGNANMVKLLLDRGAKIDAKTRDGLTPLHCG-ARSGH-EQVVEMLLDRAAPILSKTKNG
        280       290       300        310        320       330    

               50        60        70        80        90       100
pF1KB6 RTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN
        . :: : .. : . :..::: .:::.:  .   . ::.::  :. ...:.:: : :. :
XP_016 LSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPN
          340       350       360       370       380       390    

              110       120       130       140       150       160
pF1KB6 AVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLY
       :   :: :::: : .::: ..  .::. ::. .:  .   : .: ::  :.....  :..
XP_016 AKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMH
          400       410       420       430       440       450    

              170       180       190       200       210          
pF1KB6 YKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV-AKGGLGLI
       . :: :  ...:.: ::.:    ..: .. ::..::..  . :...:::.. :. : . :
XP_016 HGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADI
          460       470       480       490       500       510    

     220                                                           
pF1KB6 LKRMVEG                                                     
       ......                                                      
XP_016 VQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAK
          520       530       540       550       560       570    

>--
 initn: 427 init1: 266 opt: 319  Z-score: 256.2  bits: 57.6 E(85289): 1.6e-07
Smith-Waterman score: 332; 31.1% identity (66.7% similar) in 225 aa overlap (4-225:70-289)

                                           10         20        30 
pF1KB6                            MEGCVSN-LMVCNLAYS-GKLEELKESILADKS
                                     : .: : . .:: . :..: ..: .  . .
XP_016 DANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREAN
      40        50        60        70        80        90         

              40        50        60        70        80        90 
pF1KB6 LATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKA
       . . : . . :::: :  ::..:.:. :.  :. :: ... :..::..::. .. :.:: 
XP_016 VDAATKKGN-TALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKF
     100        110       120       130       140       150        

             100       110       120       130       140       150 
pF1KB6 LLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGN
       :: .::. . ....: :::  : .... ... .:::.    :.: . .  :.: :: : .
XP_016 LLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN----DTKGKVRLPALHIAARKDD
      160       170       180       190           200       210    

             160       170       180       190       200       210 
pF1KB6 LKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV
        :   .::    ......  : ::::.:     .. : ::....:.. .  ... :::.:
XP_016 TKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHV
          220       230       240       250       260       270    

              220                                                  
pF1KB6 A-KGGLGLILKRMVEG                                            
       : : : . ..: ...                                             
XP_016 ASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNG
          280       290       300       310       320       330    




226 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 12:43:26 2016 done: Fri Nov  4 12:43:27 2016
 Total Scan time:  6.240 Total Display time:  0.060

Function used was FASTA [36.3.4 Apr, 2011]
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