FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6943, 183 aa 1>>>pF1KB6943 183 - 183 aa - 183 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5460+/-0.000295; mu= 12.7645+/- 0.018 mean_var=77.8690+/-15.773, 0's: 0 Z-trim(118.9): 6 B-trim: 0 in 0/54 Lambda= 0.145342 statistics sampled from 32237 (32243) to 32237 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.75), E-opt: 0.2 (0.378), width: 16 Scan time: 5.030 The best scores are: opt bits E(85289) NP_001193575 (OMIM: 609191) A-kinase-interacting p ( 183) 1223 265.0 4.9e-71 XP_016873501 (OMIM: 609191) PREDICTED: A-kinase-in ( 168) 929 203.3 1.6e-52 NP_001193577 (OMIM: 609191) A-kinase-interacting p ( 156) 755 166.8 1.5e-41 NP_001193576 (OMIM: 609191) A-kinase-interacting p ( 183) 739 163.5 1.7e-40 XP_016873500 (OMIM: 609191) PREDICTED: A-kinase-in ( 210) 725 160.6 1.5e-39 NP_065693 (OMIM: 609191) A-kinase-interacting prot ( 210) 725 160.6 1.5e-39 >>NP_001193575 (OMIM: 609191) A-kinase-interacting prote (183 aa) initn: 1223 init1: 1223 opt: 1223 Z-score: 1396.3 bits: 265.0 E(85289): 4.9e-71 Smith-Waterman score: 1223; 100.0% identity (100.0% similar) in 183 aa overlap (1-183:1-183) 10 20 30 40 50 60 pF1KB6 MDNCLAAAALNGVDRRSLQRSARLALEVLERAKRRAVDWHALERPKGCMGVLAREAPHLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDNCLAAAALNGVDRRSLQRSARLALEVLERAKRRAVDWHALERPKGCMGVLAREAPHLE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 KQPAAGPQRVLPGEKYYSSVPEEGGATHVYRYHRGESKLHMCLDIGNGQRKDRKKTSLGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KQPAAGPQRVLPGEKYYSSVPEEGGATHVYRYHRGESKLHMCLDIGNGQRKDRKKTSLGP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 GGSYQISEHAPEASQPAENISKDLYIEVYPGTYSVTVGSNDLTKKTHVVAVDSGQSVDLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGSYQISEHAPEASQPAENISKDLYIEVYPGTYSVTVGSNDLTKKTHVVAVDSGQSVDLV 130 140 150 160 170 180 pF1KB6 FPV ::: NP_001 FPV >>XP_016873501 (OMIM: 609191) PREDICTED: A-kinase-intera (168 aa) initn: 929 init1: 929 opt: 929 Z-score: 1063.7 bits: 203.3 E(85289): 1.6e-52 Smith-Waterman score: 929; 100.0% identity (100.0% similar) in 136 aa overlap (1-136:1-136) 10 20 30 40 50 60 pF1KB6 MDNCLAAAALNGVDRRSLQRSARLALEVLERAKRRAVDWHALERPKGCMGVLAREAPHLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MDNCLAAAALNGVDRRSLQRSARLALEVLERAKRRAVDWHALERPKGCMGVLAREAPHLE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 KQPAAGPQRVLPGEKYYSSVPEEGGATHVYRYHRGESKLHMCLDIGNGQRKDRKKTSLGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KQPAAGPQRVLPGEKYYSSVPEEGGATHVYRYHRGESKLHMCLDIGNGQRKDRKKTSLGP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 GGSYQISEHAPEASQPAENISKDLYIEVYPGTYSVTVGSNDLTKKTHVVAVDSGQSVDLV :::::::::::::::: XP_016 GGSYQISEHAPEASQPVSTELLTHWVSPPLQLHEPVDMVLRGLFELSL 130 140 150 160 >>NP_001193577 (OMIM: 609191) A-kinase-interacting prote (156 aa) initn: 749 init1: 749 opt: 755 Z-score: 867.0 bits: 166.8 E(85289): 1.5e-41 Smith-Waterman score: 976; 85.2% identity (85.2% similar) in 183 aa overlap (1-183:1-156) 10 20 30 40 50 60 pF1KB6 MDNCLAAAALNGVDRRSLQRSARLALEVLERAKRRAVDWHALERPKGCMGVLAREAPHLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDNCLAAAALNGVDRRSLQRSARLALEVLERAKRRAVDWHALERPKGCMGVLAREAPHLE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 KQPAAGPQRVLPGEKYYSSVPEEGGATHVYRYHRGESKLHMCLDIGNGQRKDRKKTSLGP ::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KQPAAGPQRVLPGEKYYSSVPEEGGATHVYRYHRGESKLHMCLDIGNGQ----------- 70 80 90 100 130 140 150 160 170 180 pF1KB6 GGSYQISEHAPEASQPAENISKDLYIEVYPGTYSVTVGSNDLTKKTHVVAVDSGQSVDLV :::::::::::::::::::::::::::::::::::::::::::: NP_001 ----------------AENISKDLYIEVYPGTYSVTVGSNDLTKKTHVVAVDSGQSVDLV 110 120 130 140 150 pF1KB6 FPV ::: NP_001 FPV >>NP_001193576 (OMIM: 609191) A-kinase-interacting prote (183 aa) initn: 730 init1: 730 opt: 739 Z-score: 847.8 bits: 163.5 E(85289): 1.7e-40 Smith-Waterman score: 912; 74.3% identity (74.3% similar) in 210 aa overlap (1-183:1-183) 10 20 30 40 50 60 pF1KB6 MDNCLAAAALNGVDRRSLQRSARLALEVLERAKRRAVDWHALERPKGCMGVLAREAPHLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDNCLAAAALNGVDRRSLQRSARLALEVLERAKRRAVDWHALERPKGCMGVLAREAPHLE 10 20 30 40 50 60 70 80 90 pF1KB6 KQPAAGPQRVLPGE---------------------------KYYSSVPEEGGATHVYRYH :::::::::::::: ::::::::::::::::::: NP_001 KQPAAGPQRVLPGEREERPPTLSASFRTMAEFMDYTSSQCGKYYSSVPEEGGATHVYRYH 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB6 RGESKLHMCLDIGNGQRKDRKKTSLGPGGSYQISEHAPEASQPAENISKDLYIEVYPGTY :::::::::::::::: ::::::::::::::::: NP_001 RGESKLHMCLDIGNGQ---------------------------AENISKDLYIEVYPGTY 130 140 150 160 170 180 pF1KB6 SVTVGSNDLTKKTHVVAVDSGQSVDLVFPV :::::::::::::::::::::::::::::: NP_001 SVTVGSNDLTKKTHVVAVDSGQSVDLVFPV 160 170 180 >>XP_016873500 (OMIM: 609191) PREDICTED: A-kinase-intera (210 aa) initn: 1212 init1: 725 opt: 725 Z-score: 831.1 bits: 160.6 E(85289): 1.5e-39 Smith-Waterman score: 1159; 87.1% identity (87.1% similar) in 210 aa overlap (1-183:1-210) 10 20 30 40 50 60 pF1KB6 MDNCLAAAALNGVDRRSLQRSARLALEVLERAKRRAVDWHALERPKGCMGVLAREAPHLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MDNCLAAAALNGVDRRSLQRSARLALEVLERAKRRAVDWHALERPKGCMGVLAREAPHLE 10 20 30 40 50 60 70 80 90 pF1KB6 KQPAAGPQRVLPGE---------------------------KYYSSVPEEGGATHVYRYH :::::::::::::: ::::::::::::::::::: XP_016 KQPAAGPQRVLPGEREERPPTLSASFRTMAEFMDYTSSQCGKYYSSVPEEGGATHVYRYH 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB6 RGESKLHMCLDIGNGQRKDRKKTSLGPGGSYQISEHAPEASQPAENISKDLYIEVYPGTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RGESKLHMCLDIGNGQRKDRKKTSLGPGGSYQISEHAPEASQPAENISKDLYIEVYPGTY 130 140 150 160 170 180 160 170 180 pF1KB6 SVTVGSNDLTKKTHVVAVDSGQSVDLVFPV :::::::::::::::::::::::::::::: XP_016 SVTVGSNDLTKKTHVVAVDSGQSVDLVFPV 190 200 210 >>NP_065693 (OMIM: 609191) A-kinase-interacting protein (210 aa) initn: 1212 init1: 725 opt: 725 Z-score: 831.1 bits: 160.6 E(85289): 1.5e-39 Smith-Waterman score: 1159; 87.1% identity (87.1% similar) in 210 aa overlap (1-183:1-210) 10 20 30 40 50 60 pF1KB6 MDNCLAAAALNGVDRRSLQRSARLALEVLERAKRRAVDWHALERPKGCMGVLAREAPHLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 MDNCLAAAALNGVDRRSLQRSARLALEVLERAKRRAVDWHALERPKGCMGVLAREAPHLE 10 20 30 40 50 60 70 80 90 pF1KB6 KQPAAGPQRVLPGE---------------------------KYYSSVPEEGGATHVYRYH :::::::::::::: ::::::::::::::::::: NP_065 KQPAAGPQRVLPGEREERPPTLSASFRTMAEFMDYTSSQCGKYYSSVPEEGGATHVYRYH 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB6 RGESKLHMCLDIGNGQRKDRKKTSLGPGGSYQISEHAPEASQPAENISKDLYIEVYPGTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 RGESKLHMCLDIGNGQRKDRKKTSLGPGGSYQISEHAPEASQPAENISKDLYIEVYPGTY 130 140 150 160 170 180 160 170 180 pF1KB6 SVTVGSNDLTKKTHVVAVDSGQSVDLVFPV :::::::::::::::::::::::::::::: NP_065 SVTVGSNDLTKKTHVVAVDSGQSVDLVFPV 190 200 210 183 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 11:37:15 2016 done: Fri Nov 4 11:37:15 2016 Total Scan time: 5.030 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]