FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6953, 212 aa 1>>>pF1KB6953 212 - 212 aa - 212 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6141+/-0.000617; mu= 12.8088+/- 0.037 mean_var=75.4872+/-14.985, 0's: 0 Z-trim(112.4): 14 B-trim: 135 in 1/51 Lambda= 0.147617 statistics sampled from 13154 (13166) to 13154 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.776), E-opt: 0.2 (0.404), width: 16 Scan time: 1.640 The best scores are: opt bits E(32554) CCDS4522.1 EDN1 gene_id:1906|Hs108|chr6 ( 212) 1497 327.3 4.4e-90 CCDS13479.1 EDN3 gene_id:1908|Hs108|chr20 ( 219) 314 75.3 3.2e-14 CCDS13477.1 EDN3 gene_id:1908|Hs108|chr20 ( 238) 314 75.4 3.4e-14 CCDS77597.1 EDN3 gene_id:1908|Hs108|chr20 ( 192) 309 74.2 5.9e-14 CCDS13478.1 EDN3 gene_id:1908|Hs108|chr20 ( 224) 309 74.3 6.7e-14 CCDS462.1 EDN2 gene_id:1907|Hs108|chr1 ( 178) 276 67.2 7.3e-12 >>CCDS4522.1 EDN1 gene_id:1906|Hs108|chr6 (212 aa) initn: 1497 init1: 1497 opt: 1497 Z-score: 1730.7 bits: 327.3 E(32554): 4.4e-90 Smith-Waterman score: 1497; 100.0% identity (100.0% similar) in 212 aa overlap (1-212:1-212) 10 20 30 40 50 60 pF1KB6 MDYLLMIFSLLFVACQGAPETAVLGAELSAVGENGGEKPTPSPPWRLRRSKRCSCSSLMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 MDYLLMIFSLLFVACQGAPETAVLGAELSAVGENGGEKPTPSPPWRLRRSKRCSCSSLMD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 KECVYFCHLDIIWVNTPEHVVPYGLGSPRSKRALENLLPTKATDRENRCQCASQKDKKCW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 KECVYFCHLDIIWVNTPEHVVPYGLGSPRSKRALENLLPTKATDRENRCQCASQKDKKCW 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 NFCQAGKELRAEDIMEKDWNNHKKGKDCSKLGKKCIYQQLVRGRKIRRSSEEHLRQTRSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 NFCQAGKELRAEDIMEKDWNNHKKGKDCSKLGKKCIYQQLVRGRKIRRSSEEHLRQTRSE 130 140 150 160 170 180 190 200 210 pF1KB6 TMRNSVKSSFHDPKLKGKPSRERYVTHNRAHW :::::::::::::::::::::::::::::::: CCDS45 TMRNSVKSSFHDPKLKGKPSRERYVTHNRAHW 190 200 210 >>CCDS13479.1 EDN3 gene_id:1908|Hs108|chr20 (219 aa) initn: 320 init1: 231 opt: 314 Z-score: 368.9 bits: 75.3 E(32554): 3.2e-14 Smith-Waterman score: 314; 37.6% identity (63.8% similar) in 141 aa overlap (13-146:58-196) 10 20 30 40 pF1KB6 MDYLLMIFSLLFVACQGAPETAVLGAELSAVGENGGEKPTPS :: : .: . . . : : :. . . CCDS13 AGRRGVSQAPTAARSEGDCEETVAGPGEETVAGPGEGTVAPTALQGPSPGSPGQEQAAEG 30 40 50 60 70 80 50 60 70 80 90 pF1KB6 PPWRLRRSKRCSCSSLMDKECVYFCHLDIIWVNTPEHVVPYGL----GSPRSKRALENLL : . .::.::.: . ::::::.:::::::.::::..::::: :: :.::. . : CCDS13 AP-EHHRSRRCTCFTYKDKECVYYCHLDIIWINTPEQTVPYGLSNYRGSFRGKRS-AGPL 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB6 P--TKATDREN-RCQCASQKDKKCWNFCQAGKELRAEDIMEKDWNNHKKGKDCSKLGKKC : . . : . :: :... :: : .:: .. ... . .....:: CCDS13 PGNLQLSHRPHLRCACVGRYDKACLHFCTQTLDVSSNSRTAEKTDKEEEGKVRGANRGLC 150 160 170 180 190 200 160 170 180 190 200 210 pF1KB6 IYQQLVRGRKIRRSSEEHLRQTRSETMRNSVKSSFHDPKLKGKPSRERYVTHNRAHW CCDS13 QRRLKSRTNKASRL 210 >>CCDS13477.1 EDN3 gene_id:1908|Hs108|chr20 (238 aa) initn: 320 init1: 231 opt: 314 Z-score: 368.4 bits: 75.4 E(32554): 3.4e-14 Smith-Waterman score: 314; 37.6% identity (63.8% similar) in 141 aa overlap (13-146:58-196) 10 20 30 40 pF1KB6 MDYLLMIFSLLFVACQGAPETAVLGAELSAVGENGGEKPTPS :: : .: . . . : : :. . . CCDS13 AGRRGVSQAPTAARSEGDCEETVAGPGEETVAGPGEGTVAPTALQGPSPGSPGQEQAAEG 30 40 50 60 70 80 50 60 70 80 90 pF1KB6 PPWRLRRSKRCSCSSLMDKECVYFCHLDIIWVNTPEHVVPYGL----GSPRSKRALENLL : . .::.::.: . ::::::.:::::::.::::..::::: :: :.::. . : CCDS13 AP-EHHRSRRCTCFTYKDKECVYYCHLDIIWINTPEQTVPYGLSNYRGSFRGKRS-AGPL 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB6 P--TKATDREN-RCQCASQKDKKCWNFCQAGKELRAEDIMEKDWNNHKKGKDCSKLGKKC : . . : . :: :... :: : .:: .. ... . .....:: CCDS13 PGNLQLSHRPHLRCACVGRYDKACLHFCTQTLDVSSNSRTAEKTDKEEEGKVEVKDQQSK 150 160 170 180 190 200 160 170 180 190 200 210 pF1KB6 IYQQLVRGRKIRRSSEEHLRQTRSETMRNSVKSSFHDPKLKGKPSRERYVTHNRAHW CCDS13 QALDLHHPKLMPGSGLALAPSTCPRCLFQEGAP 210 220 230 >>CCDS77597.1 EDN3 gene_id:1908|Hs108|chr20 (192 aa) initn: 315 init1: 231 opt: 309 Z-score: 364.0 bits: 74.2 E(32554): 5.9e-14 Smith-Waterman score: 309; 43.2% identity (65.3% similar) in 118 aa overlap (13-123:58-173) 10 20 30 40 pF1KB6 MDYLLMIFSLLFVACQGAPETAVLGAELSAVGENGGEKPTPS :: : .: . . . : : :. . . CCDS77 AGRRGVSQAPTAARSEGDCEETVAGPGEETVAGPGEGTVAPTALQGPSPGSPGQEQAAEG 30 40 50 60 70 80 50 60 70 80 90 pF1KB6 PPWRLRRSKRCSCSSLMDKECVYFCHLDIIWVNTPEHVVPYGL----GSPRSKRALENLL : . .::.::.: . ::::::.:::::::.::::..::::: :: :.::. . : CCDS77 APEH-HRSRRCTCFTYKDKECVYYCHLDIIWINTPEQTVPYGLSNYRGSFRGKRS-AGPL 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB6 P--TKATDREN-RCQCASQKDKKCWNFCQAGKELRAEDIMEKDWNNHKKGKDCSKLGKKC : . . : . :: :... :: : .:: CCDS77 PGNLQLSHRPHLRCACVGRYDKACLHFCTQTLDVSRLKSRTNKASRL 150 160 170 180 190 >>CCDS13478.1 EDN3 gene_id:1908|Hs108|chr20 (224 aa) initn: 339 init1: 231 opt: 309 Z-score: 363.0 bits: 74.3 E(32554): 6.7e-14 Smith-Waterman score: 310; 35.5% identity (61.4% similar) in 166 aa overlap (13-159:58-221) 10 20 30 40 pF1KB6 MDYLLMIFSLLFVACQGAPETAVLGAELSAVGENGGEKPTPS :: : .: . . . : : :. . . CCDS13 AGRRGVSQAPTAARSEGDCEETVAGPGEETVAGPGEGTVAPTALQGPSPGSPGQEQAAEG 30 40 50 60 70 80 50 60 70 80 90 pF1KB6 PPWRLRRSKRCSCSSLMDKECVYFCHLDIIWVNTPEHVVPYGL----GSPRSKRALENLL : . .::.::.: . ::::::.:::::::.::::..::::: :: :.::. . : CCDS13 AP-EHHRSRRCTCFTYKDKECVYYCHLDIIWINTPEQTVPYGLSNYRGSFRGKRS-AGPL 90 100 110 120 130 140 100 110 120 130 140 pF1KB6 P--TKATDREN-RCQCASQKDKKCWNFC----QAGKELRAEDIMEKDWNN--HKKGKDCS : . . : . :: :... :: : .:: .........: . :. . : : : CCDS13 PGNLQLSHRPHLRCACVGRYDKACLHFCTQTLDVSRQVEVKDQQSKQALDLHHPKLMPGS 150 160 170 180 190 200 150 160 170 180 190 200 pF1KB6 KLG------KKCIYQQLVRGRKIRRSSEEHLRQTRSETMRNSVKSSFHDPKLKGKPSRER :. .:..:. CCDS13 GLALAPSTCPRCLFQEGAP 210 220 >>CCDS462.1 EDN2 gene_id:1907|Hs108|chr1 (178 aa) initn: 341 init1: 254 opt: 276 Z-score: 326.5 bits: 67.2 E(32554): 7.3e-12 Smith-Waterman score: 323; 39.0% identity (57.3% similar) in 164 aa overlap (49-212:45-175) 20 30 40 50 60 70 pF1KB6 PETAVLGAELSAVGENGGEKPTPSPPWRLRRSKRCSCSSLMDKECVYFCHLDIIWVNTPE : .:::::: .::::::::::::::::::: CCDS46 LLVALHEGKGQAAATLEQPASSSHAQGTHLRLRRCSCSSWLDKECVYFCHLDIIWVNTPE 20 30 40 50 60 70 80 90 100 110 120 130 pF1KB6 HVVPYGLGSPRSKRALENLLPTKATDRENRCQCASQKDKKCWNFCQAGKELRAEDIMEKD ...:::::.: .: . :: ::::.: .: : .:: ... CCDS46 QTAPYGLGNPPRRR--RRSLPR-------RCQCSSARDPACATFC-----------LRRP 80 90 100 110 140 150 160 170 180 190 pF1KB6 WNNHKKGKDCSKLGKKCIYQQLVRGRKIRRSSEEHLRQTRSETMRNSVKSSFHDPKLKGK :. . : :. . ..: : : .. : :.. :. . .::: : : . . CCDS46 WT--EAGAVPSRKSPADVFQ---TG-KTGATTGELLQRLRDIS---TVKSLF--AKRQQE 120 130 140 150 160 200 210 pF1KB6 PSRERYVTHNRAHW :: ::.: : CCDS46 AMREPRSTHSR--WRKR 170 212 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 11:23:34 2016 done: Fri Nov 4 11:23:35 2016 Total Scan time: 1.640 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]