FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6961, 175 aa 1>>>pF1KB6961 175 - 175 aa - 175 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9132+/-0.000412; mu= 14.6015+/- 0.026 mean_var=56.6947+/-11.427, 0's: 0 Z-trim(109.2): 24 B-trim: 120 in 1/51 Lambda= 0.170335 statistics sampled from 17371 (17388) to 17371 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.562), E-opt: 0.2 (0.204), width: 16 Scan time: 5.190 The best scores are: opt bits E(85289) NP_057142 (OMIM: 608680) EKC/KEOPS complex subunit ( 175) 1092 276.6 1.5e-74 XP_016859723 (OMIM: 608680) PREDICTED: EKC/KEOPS c ( 175) 1092 276.6 1.5e-74 NP_001317317 (OMIM: 608680) EKC/KEOPS complex subu ( 175) 1092 276.6 1.5e-74 NP_001317318 (OMIM: 608680) EKC/KEOPS complex subu ( 175) 1092 276.6 1.5e-74 NP_001317320 (OMIM: 608680) EKC/KEOPS complex subu ( 142) 784 200.8 7.5e-52 NP_001317321 (OMIM: 608680) EKC/KEOPS complex subu ( 142) 784 200.8 7.5e-52 NP_001317319 (OMIM: 608680) EKC/KEOPS complex subu ( 157) 784 200.8 8.1e-52 XP_011531179 (OMIM: 608680) PREDICTED: EKC/KEOPS c ( 214) 784 200.9 1.1e-51 XP_016859722 (OMIM: 608680) PREDICTED: EKC/KEOPS c ( 214) 784 200.9 1.1e-51 NP_001317316 (OMIM: 608680) EKC/KEOPS complex subu ( 214) 784 200.9 1.1e-51 XP_016859721 (OMIM: 608680) PREDICTED: EKC/KEOPS c ( 214) 784 200.9 1.1e-51 XP_006712090 (OMIM: 608680) PREDICTED: EKC/KEOPS c ( 214) 784 200.9 1.1e-51 XP_011531180 (OMIM: 608680) PREDICTED: EKC/KEOPS c ( 214) 784 200.9 1.1e-51 NP_001317315 (OMIM: 608680) EKC/KEOPS complex subu ( 214) 784 200.9 1.1e-51 >>NP_057142 (OMIM: 608680) EKC/KEOPS complex subunit TPR (175 aa) initn: 1092 init1: 1092 opt: 1092 Z-score: 1459.6 bits: 276.6 E(85289): 1.5e-74 Smith-Waterman score: 1092; 100.0% identity (100.0% similar) in 175 aa overlap (1-175:1-175) 10 20 30 40 50 60 pF1KB6 MQLTHQLDLFPECRVTLLLFKDVKNAGDLRRKAMEGTIDGSLINPTVIVDPFQILVAANK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MQLTHQLDLFPECRVTLLLFKDVKNAGDLRRKAMEGTIDGSLINPTVIVDPFQILVAANK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 AVHLYKLGKMKTRTLSTEIIFNLSPNNNISEALKKFGISANDTSILIVYIEEGEKQINQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 AVHLYKLGKMKTRTLSTEIIFNLSPNNNISEALKKFGISANDTSILIVYIEEGEKQINQE 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 YLISQVEGHQVSLKNLPEIMNITEVKKIYKLSSQEESIGTLLDAIICRMSTKDVL ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 YLISQVEGHQVSLKNLPEIMNITEVKKIYKLSSQEESIGTLLDAIICRMSTKDVL 130 140 150 160 170 >>XP_016859723 (OMIM: 608680) PREDICTED: EKC/KEOPS compl (175 aa) initn: 1092 init1: 1092 opt: 1092 Z-score: 1459.6 bits: 276.6 E(85289): 1.5e-74 Smith-Waterman score: 1092; 100.0% identity (100.0% similar) in 175 aa overlap (1-175:1-175) 10 20 30 40 50 60 pF1KB6 MQLTHQLDLFPECRVTLLLFKDVKNAGDLRRKAMEGTIDGSLINPTVIVDPFQILVAANK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MQLTHQLDLFPECRVTLLLFKDVKNAGDLRRKAMEGTIDGSLINPTVIVDPFQILVAANK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 AVHLYKLGKMKTRTLSTEIIFNLSPNNNISEALKKFGISANDTSILIVYIEEGEKQINQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AVHLYKLGKMKTRTLSTEIIFNLSPNNNISEALKKFGISANDTSILIVYIEEGEKQINQE 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 YLISQVEGHQVSLKNLPEIMNITEVKKIYKLSSQEESIGTLLDAIICRMSTKDVL ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YLISQVEGHQVSLKNLPEIMNITEVKKIYKLSSQEESIGTLLDAIICRMSTKDVL 130 140 150 160 170 >>NP_001317317 (OMIM: 608680) EKC/KEOPS complex subunit (175 aa) initn: 1092 init1: 1092 opt: 1092 Z-score: 1459.6 bits: 276.6 E(85289): 1.5e-74 Smith-Waterman score: 1092; 100.0% identity (100.0% similar) in 175 aa overlap (1-175:1-175) 10 20 30 40 50 60 pF1KB6 MQLTHQLDLFPECRVTLLLFKDVKNAGDLRRKAMEGTIDGSLINPTVIVDPFQILVAANK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MQLTHQLDLFPECRVTLLLFKDVKNAGDLRRKAMEGTIDGSLINPTVIVDPFQILVAANK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 AVHLYKLGKMKTRTLSTEIIFNLSPNNNISEALKKFGISANDTSILIVYIEEGEKQINQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVHLYKLGKMKTRTLSTEIIFNLSPNNNISEALKKFGISANDTSILIVYIEEGEKQINQE 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 YLISQVEGHQVSLKNLPEIMNITEVKKIYKLSSQEESIGTLLDAIICRMSTKDVL ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YLISQVEGHQVSLKNLPEIMNITEVKKIYKLSSQEESIGTLLDAIICRMSTKDVL 130 140 150 160 170 >>NP_001317318 (OMIM: 608680) EKC/KEOPS complex subunit (175 aa) initn: 1092 init1: 1092 opt: 1092 Z-score: 1459.6 bits: 276.6 E(85289): 1.5e-74 Smith-Waterman score: 1092; 100.0% identity (100.0% similar) in 175 aa overlap (1-175:1-175) 10 20 30 40 50 60 pF1KB6 MQLTHQLDLFPECRVTLLLFKDVKNAGDLRRKAMEGTIDGSLINPTVIVDPFQILVAANK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MQLTHQLDLFPECRVTLLLFKDVKNAGDLRRKAMEGTIDGSLINPTVIVDPFQILVAANK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 AVHLYKLGKMKTRTLSTEIIFNLSPNNNISEALKKFGISANDTSILIVYIEEGEKQINQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVHLYKLGKMKTRTLSTEIIFNLSPNNNISEALKKFGISANDTSILIVYIEEGEKQINQE 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 YLISQVEGHQVSLKNLPEIMNITEVKKIYKLSSQEESIGTLLDAIICRMSTKDVL ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YLISQVEGHQVSLKNLPEIMNITEVKKIYKLSSQEESIGTLLDAIICRMSTKDVL 130 140 150 160 170 >>NP_001317320 (OMIM: 608680) EKC/KEOPS complex subunit (142 aa) initn: 877 init1: 784 opt: 784 Z-score: 1051.9 bits: 200.8 E(85289): 7.5e-52 Smith-Waterman score: 811; 81.1% identity (81.1% similar) in 175 aa overlap (1-175:1-142) 10 20 30 40 50 60 pF1KB6 MQLTHQLDLFPECRVTLLLFKDVKNAGDLRRKAMEGTIDGSLINPTVIVDPFQILVAANK :::::::::::::: ::::::::::::: NP_001 MQLTHQLDLFPECR---------------------------------IVDPFQILVAANK 10 20 70 80 90 100 110 120 pF1KB6 AVHLYKLGKMKTRTLSTEIIFNLSPNNNISEALKKFGISANDTSILIVYIEEGEKQINQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVHLYKLGKMKTRTLSTEIIFNLSPNNNISEALKKFGISANDTSILIVYIEEGEKQINQE 30 40 50 60 70 80 130 140 150 160 170 pF1KB6 YLISQVEGHQVSLKNLPEIMNITEVKKIYKLSSQEESIGTLLDAIICRMSTKDVL ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YLISQVEGHQVSLKNLPEIMNITEVKKIYKLSSQEESIGTLLDAIICRMSTKDVL 90 100 110 120 130 140 >>NP_001317321 (OMIM: 608680) EKC/KEOPS complex subunit (142 aa) initn: 877 init1: 784 opt: 784 Z-score: 1051.9 bits: 200.8 E(85289): 7.5e-52 Smith-Waterman score: 811; 81.1% identity (81.1% similar) in 175 aa overlap (1-175:1-142) 10 20 30 40 50 60 pF1KB6 MQLTHQLDLFPECRVTLLLFKDVKNAGDLRRKAMEGTIDGSLINPTVIVDPFQILVAANK :::::::::::::: ::::::::::::: NP_001 MQLTHQLDLFPECR---------------------------------IVDPFQILVAANK 10 20 70 80 90 100 110 120 pF1KB6 AVHLYKLGKMKTRTLSTEIIFNLSPNNNISEALKKFGISANDTSILIVYIEEGEKQINQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVHLYKLGKMKTRTLSTEIIFNLSPNNNISEALKKFGISANDTSILIVYIEEGEKQINQE 30 40 50 60 70 80 130 140 150 160 170 pF1KB6 YLISQVEGHQVSLKNLPEIMNITEVKKIYKLSSQEESIGTLLDAIICRMSTKDVL ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YLISQVEGHQVSLKNLPEIMNITEVKKIYKLSSQEESIGTLLDAIICRMSTKDVL 90 100 110 120 130 140 >>NP_001317319 (OMIM: 608680) EKC/KEOPS complex subunit (157 aa) initn: 784 init1: 784 opt: 784 Z-score: 1051.2 bits: 200.8 E(85289): 8.1e-52 Smith-Waterman score: 784; 100.0% identity (100.0% similar) in 128 aa overlap (48-175:30-157) 20 30 40 50 60 70 pF1KB6 LLFKDVKNAGDLRRKAMEGTIDGSLINPTVIVDPFQILVAANKAVHLYKLGKMKTRTLST :::::::::::::::::::::::::::::: NP_001 MARSWLTATSASRVQAIVLPQPPELLGLQIVDPFQILVAANKAVHLYKLGKMKTRTLST 10 20 30 40 50 80 90 100 110 120 130 pF1KB6 EIIFNLSPNNNISEALKKFGISANDTSILIVYIEEGEKQINQEYLISQVEGHQVSLKNLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EIIFNLSPNNNISEALKKFGISANDTSILIVYIEEGEKQINQEYLISQVEGHQVSLKNLP 60 70 80 90 100 110 140 150 160 170 pF1KB6 EIMNITEVKKIYKLSSQEESIGTLLDAIICRMSTKDVL :::::::::::::::::::::::::::::::::::::: NP_001 EIMNITEVKKIYKLSSQEESIGTLLDAIICRMSTKDVL 120 130 140 150 >>XP_011531179 (OMIM: 608680) PREDICTED: EKC/KEOPS compl (214 aa) initn: 1078 init1: 784 opt: 784 Z-score: 1049.2 bits: 200.9 E(85289): 1.1e-51 Smith-Waterman score: 958; 81.2% identity (81.2% similar) in 207 aa overlap (8-175:8-214) 10 20 30 40 pF1KB6 MQLTHQLDLFPECRVTLLLFKDVKNAGDLRRKAMEGTIDGSLINPTV------------- :::::::::::::::::::::::::::::::::::::::: XP_011 MQLTHQLDLFPECRVTLLLFKDVKNAGDLRRKAMEGTIDGSLINPTVFHSCCPGWSAMAR 10 20 30 40 50 60 50 60 70 80 pF1KB6 --------------------------IVDPFQILVAANKAVHLYKLGKMKTRTLSTEIIF :::::::::::::::::::::::::::::::::: XP_011 SWLTATSASRVQAIVLPQPPELLGLQIVDPFQILVAANKAVHLYKLGKMKTRTLSTEIIF 70 80 90 100 110 120 90 100 110 120 130 140 pF1KB6 NLSPNNNISEALKKFGISANDTSILIVYIEEGEKQINQEYLISQVEGHQVSLKNLPEIMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NLSPNNNISEALKKFGISANDTSILIVYIEEGEKQINQEYLISQVEGHQVSLKNLPEIMN 130 140 150 160 170 180 150 160 170 pF1KB6 ITEVKKIYKLSSQEESIGTLLDAIICRMSTKDVL :::::::::::::::::::::::::::::::::: XP_011 ITEVKKIYKLSSQEESIGTLLDAIICRMSTKDVL 190 200 210 >>XP_016859722 (OMIM: 608680) PREDICTED: EKC/KEOPS compl (214 aa) initn: 1078 init1: 784 opt: 784 Z-score: 1049.2 bits: 200.9 E(85289): 1.1e-51 Smith-Waterman score: 958; 81.2% identity (81.2% similar) in 207 aa overlap (8-175:8-214) 10 20 30 40 pF1KB6 MQLTHQLDLFPECRVTLLLFKDVKNAGDLRRKAMEGTIDGSLINPTV------------- :::::::::::::::::::::::::::::::::::::::: XP_016 MQLTHQLDLFPECRVTLLLFKDVKNAGDLRRKAMEGTIDGSLINPTVFHSCCPGWSAMAR 10 20 30 40 50 60 50 60 70 80 pF1KB6 --------------------------IVDPFQILVAANKAVHLYKLGKMKTRTLSTEIIF :::::::::::::::::::::::::::::::::: XP_016 SWLTATSASRVQAIVLPQPPELLGLQIVDPFQILVAANKAVHLYKLGKMKTRTLSTEIIF 70 80 90 100 110 120 90 100 110 120 130 140 pF1KB6 NLSPNNNISEALKKFGISANDTSILIVYIEEGEKQINQEYLISQVEGHQVSLKNLPEIMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NLSPNNNISEALKKFGISANDTSILIVYIEEGEKQINQEYLISQVEGHQVSLKNLPEIMN 130 140 150 160 170 180 150 160 170 pF1KB6 ITEVKKIYKLSSQEESIGTLLDAIICRMSTKDVL :::::::::::::::::::::::::::::::::: XP_016 ITEVKKIYKLSSQEESIGTLLDAIICRMSTKDVL 190 200 210 >>NP_001317316 (OMIM: 608680) EKC/KEOPS complex subunit (214 aa) initn: 1078 init1: 784 opt: 784 Z-score: 1049.2 bits: 200.9 E(85289): 1.1e-51 Smith-Waterman score: 958; 81.2% identity (81.2% similar) in 207 aa overlap (8-175:8-214) 10 20 30 40 pF1KB6 MQLTHQLDLFPECRVTLLLFKDVKNAGDLRRKAMEGTIDGSLINPTV------------- :::::::::::::::::::::::::::::::::::::::: NP_001 MQLTHQLDLFPECRVTLLLFKDVKNAGDLRRKAMEGTIDGSLINPTVFHSCCPGWSAMAR 10 20 30 40 50 60 50 60 70 80 pF1KB6 --------------------------IVDPFQILVAANKAVHLYKLGKMKTRTLSTEIIF :::::::::::::::::::::::::::::::::: NP_001 SWLTATSASRVQAIVLPQPPELLGLQIVDPFQILVAANKAVHLYKLGKMKTRTLSTEIIF 70 80 90 100 110 120 90 100 110 120 130 140 pF1KB6 NLSPNNNISEALKKFGISANDTSILIVYIEEGEKQINQEYLISQVEGHQVSLKNLPEIMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NLSPNNNISEALKKFGISANDTSILIVYIEEGEKQINQEYLISQVEGHQVSLKNLPEIMN 130 140 150 160 170 180 150 160 170 pF1KB6 ITEVKKIYKLSSQEESIGTLLDAIICRMSTKDVL :::::::::::::::::::::::::::::::::: NP_001 ITEVKKIYKLSSQEESIGTLLDAIICRMSTKDVL 190 200 210 175 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 20:40:01 2016 done: Sat Nov 5 20:40:02 2016 Total Scan time: 5.190 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]