Result of FASTA (omim) for
pF1KB6962
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6962, 240 aa
1>>>pF1KB6962 240 - 240 aa - 240 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.5824+/-0.000266; mu= 10.7075+/- 0.017
mean_var=135.8052+/-26.660, 0's: 0 Z-trim(124.2): 58 B-trim: 330 in 1/55
Lambda= 0.110057
statistics sampled from 45238 (45304) to 45238 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.843), E-opt: 0.2 (0.531), width: 16
Scan time: 7.970
The best scores are: opt bits E(85289)
NP_002169 (OMIM: 146735) insulin-like growth facto ( 240) 1743 286.9 2.1e-77
XP_016874753 (OMIM: 146735) PREDICTED: insulin-lik ( 136) 823 140.6 1.3e-33
NP_000590 (OMIM: 146734) insulin-like growth facto ( 272) 338 63.8 3.4e-10
NP_001013416 (OMIM: 146732) insulin-like growth fa ( 297) 314 60.1 5e-09
XP_016867641 (OMIM: 146732) PREDICTED: insulin-lik ( 291) 306 58.8 1.2e-08
NP_000589 (OMIM: 146732) insulin-like growth facto ( 291) 306 58.8 1.2e-08
NP_001543 (OMIM: 146733) insulin-like growth facto ( 258) 286 55.6 9.9e-08
NP_000587 (OMIM: 146730) insulin-like growth facto ( 259) 220 45.1 0.00014
NP_001300921 (OMIM: 146731) insulin-like growth fa ( 159) 213 43.8 0.00021
NP_001300922 (OMIM: 146731) insulin-like growth fa ( 159) 213 43.8 0.00021
NP_001300919 (OMIM: 146731) insulin-like growth fa ( 181) 213 43.8 0.00024
NP_000588 (OMIM: 146731) insulin-like growth facto ( 328) 206 43.0 0.00078
XP_011538706 (OMIM: 607988) PREDICTED: testican-2 ( 421) 194 41.2 0.0035
NP_055582 (OMIM: 607988) testican-2 isoform 2 prec ( 424) 194 41.2 0.0035
NP_001231879 (OMIM: 607988) testican-2 isoform 2 p ( 424) 194 41.2 0.0035
>>NP_002169 (OMIM: 146735) insulin-like growth factor-bi (240 aa)
initn: 1743 init1: 1743 opt: 1743 Z-score: 1510.5 bits: 286.9 E(85289): 2.1e-77
Smith-Waterman score: 1743; 100.0% identity (100.0% similar) in 240 aa overlap (1-240:1-240)
10 20 30 40 50 60
pF1KB6 MTPHRLLPPLLLLLALLLAASPGGALARCPGCGQGVQAGCPGGCVEEEDGGSPAEGCAEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MTPHRLLPPLLLLLALLLAASPGGALARCPGCGQGVQAGCPGGCVEEEDGGSPAEGCAEA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 EGCLRREGQECGVYTPNCAPGLQCHPPKDDEAPLRALLLGRGRCLPARAPAVAEENPKES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EGCLRREGQECGVYTPNCAPGLQCHPPKDDEAPLRALLLGRGRCLPARAPAVAEENPKES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 KPQAGTARPQDVNRRDQQRNPGTSTTPSQPNSAGVQDTEMGPCRRHLDSVLQQLQTEVYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KPQAGTARPQDVNRRDQQRNPGTSTTPSQPNSAGVQDTEMGPCRRHLDSVLQQLQTEVYR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 GAQTLYVPNCDHRGFYRKRQCRSSQGQRRGPCWCVDRMGKSLPGSPDGNGSSSCPTGSSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GAQTLYVPNCDHRGFYRKRQCRSSQGQRRGPCWCVDRMGKSLPGSPDGNGSSSCPTGSSG
190 200 210 220 230 240
>>XP_016874753 (OMIM: 146735) PREDICTED: insulin-like gr (136 aa)
initn: 821 init1: 821 opt: 823 Z-score: 724.2 bits: 140.6 E(85289): 1.3e-33
Smith-Waterman score: 823; 89.8% identity (95.3% similar) in 127 aa overlap (1-125:1-127)
10 20 30 40 50 60
pF1KB6 MTPHRLLPPLLLLLALLLAASPGGALARCPGCGQGVQAGCPGGCVEEEDGGSPAEGCAEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MTPHRLLPPLLLLLALLLAASPGGALARCPGCGQGVQAGCPGGCVEEEDGGSPAEGCAEA
10 20 30 40 50 60
70 80 90 100 110
pF1KB6 EGCLRREGQECGVYTPNCAPGLQCHPPKDDEAPLRALLLGRGRCLPARAPAV--AEENPK
:::::::::::::::::::::::::::::::::::::::::::::::::::: . .. .
XP_016 EGCLRREGQECGVYTPNCAPGLQCHPPKDDEAPLRALLLGRGRCLPARAPAVLSSPRTLR
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB6 ESKPQAGTARPQDVNRRDQQRNPGTSTTPSQPNSAGVQDTEMGPCRRHLDSVLQQLQTEV
. .:. :
XP_016 KLSPEPGATCSCRGES
130
>>NP_000590 (OMIM: 146734) insulin-like growth factor-bi (272 aa)
initn: 586 init1: 308 opt: 338 Z-score: 304.1 bits: 63.8 E(85289): 3.4e-10
Smith-Waterman score: 531; 35.1% identity (59.7% similar) in 268 aa overlap (6-239:3-268)
10 20 30 40 50
pF1KB6 MTPHRLLPPLLLLLALLLA-ASPGGALARCPGCGQGVQAGCPGGCVEEEDGGSPAEGCAE
:: .::::: . :. :....: : . . . :: . . : :. ::
NP_000 MVLLTAVLLLLAAYAGPAQSLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCM
10 20 30 40 50
60 70 80 90 100
pF1KB6 AEGCLRREGQECGVYTPNCAPGLQCHPPKDDEAPLRALLLGRGRCLPARA----------
. : ::: ::::: :: ::.: : .:.: ::.::: ::: :: ..
NP_000 T--CALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYREQVKIERD
60 70 80 90 100 110
110 120 130 140 150
pF1KB6 ------PA---VAEE--NPKESKPQ-------AGTARPQDVNRR-DQQRNPGTSTTPSQP
:. .::: .:: .:. . : .: .. :.. : . . ..:
NP_000 SREHEEPTTSEMAEETYSPKIFRPKHTRISELKAEAVKKDRRKKLTQSKFVGGAENTAHP
120 130 140 150 160 170
160 170 180 190 200
pF1KB6 NSAGV----QDTEMGPCRRHLDSVLQQLQTEVYRGAQTLYVPNCDHRGFYRKRQCRSSQG
.. :..:.::::::... ::.:.. ...:.::::..:::...::. :.:
NP_000 RIISAPEMRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRG
180 190 200 210 220 230
210 220 230 240
pF1KB6 QRRGPCWCVDRMGKSLPGSPDGNGSSSCPTGSSG
..:: :::::..: .::: .:. .: : .:
NP_000 RKRGICWCVDKYGMKLPGMEYVDGDFQCHTFDSSNVE
240 250 260 270
>>NP_001013416 (OMIM: 146732) insulin-like growth factor (297 aa)
initn: 516 init1: 298 opt: 314 Z-score: 283.0 bits: 60.1 E(85289): 5e-09
Smith-Waterman score: 471; 33.7% identity (56.7% similar) in 270 aa overlap (19-239:29-296)
10 20 30 40
pF1KB6 MTPHRLLPPLLLLLALLLAASPG-GALARCPGCGQGVQAGC-PGGCVEEE
:.: : : ..:: : . : : : : :
NP_001 MQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPPPAVCAE
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB6 DGGSPAEGCAEAEGCLRREGQECGVYTPNCAPGLQCHPPKDDEAPLRALLLGRGRCLPAR
:. :: . : ::: ::.:: :. ::.:.: :. ::.::: ::: :. :
NP_001 LVREPGCGCCLT--CALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNAS
70 80 90 100 110
110 120 130
pF1KB6 A------------PAVAEE----NPKESKPQ--AGTARPQDVNR----------------
: :: .: : .::. . ::... .:.
NP_001 AVSRLRAYLLPAPPAPGEPPAPGNASESEEDRSAGSVESPSVSSTHRVSDPKFHPLHSKI
120 130 140 150 160 170
140 150 160 170 180
pF1KB6 --------RDQQR---NPGTSTTPSQP-NSAGVQDTEMGPCRRHLDSVLQQLQTEVYRGA
.:.:: . ...: .: .: . ..::.:::::.....:..:. .
NP_001 IIIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSP
180 190 200 210 220 230
190 200 210 220 230 240
pF1KB6 QTLYVPNCDHRGFYRKRQCRSSQGQRRGPCWCVDRMGKSLPG-SPDGNGSSSCPTGSSG
. ...::::..:::.:.::: :.:..:: :::::..:. ::: . :. . : . .:
NP_001 RGVHIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYTTKGKEDVHCYSMQSK
240 250 260 270 280 290
>>XP_016867641 (OMIM: 146732) PREDICTED: insulin-like gr (291 aa)
initn: 516 init1: 298 opt: 306 Z-score: 276.3 bits: 58.8 E(85289): 1.2e-08
Smith-Waterman score: 482; 34.8% identity (58.0% similar) in 264 aa overlap (19-239:29-290)
10 20 30 40
pF1KB6 MTPHRLLPPLLLLLALLLAASPG-GALARCPGCGQGVQAGC-PGGCVEEE
:.: : : ..:: : . : : : : :
XP_016 MQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPPPAVCAE
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB6 DGGSPAEGCAEAEGCLRREGQECGVYTPNCAPGLQCHPPKDDEAPLRALLLGRGRC----
:. :: . : ::: ::.:: :. ::.:.: :. ::.::: ::: :
XP_016 LVREPGCGCCLT--CALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNAS
70 80 90 100 110
110 120 130
pF1KB6 ---------LPAR-APAVAEENPK-------ESKPQAGTARPQD------------VNR-
::: ::. : :. . :: ..: : .: ...
XP_016 AVSRLRAYLLPAPPAPGNASESEEDRSAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKG
120 130 140 150 160 170
140 150 160 170 180
pF1KB6 --RDQQR---NPGTSTTPSQP-NSAGVQDTEMGPCRRHLDSVLQQLQTEVYRGAQTLYVP
.:.:: . ...: .: .: . ..::.:::::.....:..:. . . ...:
XP_016 HAKDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIP
180 190 200 210 220 230
190 200 210 220 230 240
pF1KB6 NCDHRGFYRKRQCRSSQGQRRGPCWCVDRMGKSLPG-SPDGNGSSSCPTGSSG
:::..:::.:.::: :.:..:: :::::..:. ::: . :. . : . .:
XP_016 NCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYTTKGKEDVHCYSMQSK
240 250 260 270 280 290
>>NP_000589 (OMIM: 146732) insulin-like growth factor-bi (291 aa)
initn: 516 init1: 298 opt: 306 Z-score: 276.3 bits: 58.8 E(85289): 1.2e-08
Smith-Waterman score: 482; 34.8% identity (58.0% similar) in 264 aa overlap (19-239:29-290)
10 20 30 40
pF1KB6 MTPHRLLPPLLLLLALLLAASPG-GALARCPGCGQGVQAGC-PGGCVEEE
:.: : : ..:: : . : : : : :
NP_000 MQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPPPAVCAE
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB6 DGGSPAEGCAEAEGCLRREGQECGVYTPNCAPGLQCHPPKDDEAPLRALLLGRGRC----
:. :: . : ::: ::.:: :. ::.:.: :. ::.::: ::: :
NP_000 LVREPGCGCCLT--CALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNAS
70 80 90 100 110
110 120 130
pF1KB6 ---------LPAR-APAVAEENPK-------ESKPQAGTARPQD------------VNR-
::: ::. : :. . :: ..: : .: ...
NP_000 AVSRLRAYLLPAPPAPGNASESEEDRSAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKG
120 130 140 150 160 170
140 150 160 170 180
pF1KB6 --RDQQR---NPGTSTTPSQP-NSAGVQDTEMGPCRRHLDSVLQQLQTEVYRGAQTLYVP
.:.:: . ...: .: .: . ..::.:::::.....:..:. . . ...:
NP_000 HAKDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIP
180 190 200 210 220 230
190 200 210 220 230 240
pF1KB6 NCDHRGFYRKRQCRSSQGQRRGPCWCVDRMGKSLPG-SPDGNGSSSCPTGSSG
:::..:::.:.::: :.:..:: :::::..:. ::: . :. . : . .:
NP_000 NCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYTTKGKEDVHCYSMQSK
240 250 260 270 280 290
>>NP_001543 (OMIM: 146733) insulin-like growth factor-bi (258 aa)
initn: 400 init1: 185 opt: 286 Z-score: 259.8 bits: 55.6 E(85289): 9.9e-08
Smith-Waterman score: 460; 35.5% identity (59.0% similar) in 251 aa overlap (9-234:3-249)
10 20 30 40 50
pF1KB6 MTPHRLLPPLLLLLALLLAASPGGALA----RCPGCGQGVQAGC--PGGCVEEEDGGSPA
:: :. ::::::.:: .:. .:: :.. : : : :: :: :.
NP_001 MLPLCLVAALLLAAGPGPSLGDEAIHCPPCSEEKLARCRPPVGC--EELVREPG
10 20 30 40 50
60 70 80 90 100 110
pF1KB6 EGCAEAEGCLRREGQECGVYTPNCAPGLQCHPPKDDEAPLRALLLGRGRCLP-ARAPAVA
:: . : :. :::::: :. ::.:.::. : ::..:. :.: :. :. :.
NP_001 CGCCAT--CALGLGMPCGVYTPRCGSGLRCYPPRGVEKPLHTLMHGQGVCMELAEIEAIQ
60 70 80 90 100 110
120 130 140 150
pF1KB6 EE-NPKES----KPQAGTARPQDVNRRDQQ------RNPGTSTTPSQPNSAGVQDTE---
: .:... .:. . . . .:: : :. .:: . :.: .:..
NP_001 ESLQPSDKDEGDHPNNSFSPCSAHDRRCLQKHFAKIRDRSTSGGKMKVNGAPREDARPVP
120 130 140 150 160 170
160 170 180 190 200 210
pF1KB6 MGPCRRHLDSVLQQLQTEVYRGAQTLYV---PNCDHRGFYRKRQCRSSQGQRRGPCWCVD
.: :. .: .:..: . : . ::. ::::. : .. .::. . .:: :::::
NP_001 QGSCQSELHRALERLAASQSRTHEDLYIIPIPNCDRNGNFHPKQCHPALDGQRGKCWCVD
180 190 200 210 220 230
220 230 240
pF1KB6 R-MGKSLPGSPDGNGSSSCPTGSSG
: : .:::. . .: .:
NP_001 RKTGVKLPGGLEPKGELDCHQLADSFRE
240 250
>>NP_000587 (OMIM: 146730) insulin-like growth factor-bi (259 aa)
initn: 368 init1: 144 opt: 220 Z-score: 203.1 bits: 45.1 E(85289): 0.00014
Smith-Waterman score: 360; 30.5% identity (54.5% similar) in 246 aa overlap (10-234:11-251)
10 20 30 40 50
pF1KB6 MTPHRLLPPLLLLLALLLAASPGGALARCPGCGQGVQAGCP---GGCVEEEDGGSPAEG
:.::: . .. .:: .: :. : :: ..: : . . :
NP_000 MSEVPVARVWLVLLLLTVQVGVTAGAPWQCAPCSAEKLALCPPVSASCSEV----TRSAG
10 20 30 40 50
60 70 80 90 100 110
pF1KB6 CAEAEGCLRREGQECGVYTPNCAPGLQCHPPKDDEAPLRALLLGRGRCLP---ARAPAVA
:. : : ::: : :: ::.:. .. ::.:: :.: :. : :: .:
NP_000 CGCCPMCALPLGAACGVATARCARGLSCRALPGEQQPLHALTRGQGACVQESDASAPHAA
60 70 80 90 100 110
120 130 140 150 160
pF1KB6 EENPKESKPQAGTARPQDVNRRDQQRNPGT-------STTPSQPNSAGVQDTEMG----P
: . :: :.. ... . :. .. . .: ... :.. :
NP_000 EAGSPES-PESTEITEEELLDNFHLMAPSEEDHSILWDAISTYDGSKALHVTNIKKWKEP
120 130 140 150 160 170
170 180 190 200 210
pF1KB6 CRRHLDSVLQQL-QTEVYRGAQT--LYVPNCDHRGFYRKRQCRSSQGQRRGPCWCV-DRM
:: .: :...: ... : . .:.:::.. :::..:::..:. . : ::::
NP_000 CRIELYRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWN
180 190 200 210 220 230
220 230 240
pF1KB6 GKSLPGSPDGNGSSSCPTGSSG
:: .::::. :. .:
NP_000 GKRIPGSPEIRGDPNCQIYFNVQN
240 250
>>NP_001300921 (OMIM: 146731) insulin-like growth factor (159 aa)
initn: 183 init1: 139 opt: 213 Z-score: 199.9 bits: 43.8 E(85289): 0.00021
Smith-Waterman score: 213; 38.3% identity (65.4% similar) in 81 aa overlap (162-234:60-140)
140 150 160 170 180
pF1KB6 VNRRDQQRNPGTSTTPSQPNSAGVQDTEMGPCRRHLDSVLQQLQTEVY---RGA----QT
::...::.::....: :: .
NP_001 TEQHRQMGKGGKHHLGLEEPKKLRPPPARTPCQQELDQVLERISTMRLPDERGPLEHLYS
30 40 50 60 70 80
190 200 210 220 230 240
pF1KB6 LYVPNCDHRGFYRKRQCRSSQGQRRGPCWCVD-RMGKSLPGSPDGNGSSSCPTGSSG
:..::::..:.: .::. : . .:: ::::. :: . :.: :. :
NP_001 LHIPNCDKHGLYNLKQCKMSLNGQRGECWCVNPNTGKLIQGAPTIRGDPECHLFYNEQQE
90 100 110 120 130 140
NP_001 ARGVHTQRMQ
150
>>NP_001300922 (OMIM: 146731) insulin-like growth factor (159 aa)
initn: 183 init1: 139 opt: 213 Z-score: 199.9 bits: 43.8 E(85289): 0.00021
Smith-Waterman score: 213; 38.3% identity (65.4% similar) in 81 aa overlap (162-234:60-140)
140 150 160 170 180
pF1KB6 VNRRDQQRNPGTSTTPSQPNSAGVQDTEMGPCRRHLDSVLQQLQTEVY---RGA----QT
::...::.::....: :: .
NP_001 TEQHRQMGKGGKHHLGLEEPKKLRPPPARTPCQQELDQVLERISTMRLPDERGPLEHLYS
30 40 50 60 70 80
190 200 210 220 230 240
pF1KB6 LYVPNCDHRGFYRKRQCRSSQGQRRGPCWCVD-RMGKSLPGSPDGNGSSSCPTGSSG
:..::::..:.: .::. : . .:: ::::. :: . :.: :. :
NP_001 LHIPNCDKHGLYNLKQCKMSLNGQRGECWCVNPNTGKLIQGAPTIRGDPECHLFYNEQQE
90 100 110 120 130 140
NP_001 ARGVHTQRMQ
150
240 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 14:34:06 2016 done: Sat Nov 5 14:34:08 2016
Total Scan time: 7.970 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]