FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6963, 214 aa 1>>>pF1KB6963 214 - 214 aa - 214 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.7256+/-0.000518; mu= -3.0523+/- 0.031 mean_var=519.0368+/-113.288, 0's: 0 Z-trim(118.2): 42 B-trim: 446 in 2/56 Lambda= 0.056296 statistics sampled from 30846 (30889) to 30846 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.723), E-opt: 0.2 (0.362), width: 16 Scan time: 4.590 The best scores are: opt bits E(85289) NP_036515 (OMIM: 610180) osteoclast-stimulating fa ( 214) 1443 131.4 1.1e-30 XP_006717116 (OMIM: 610180) PREDICTED: osteoclast- ( 217) 1427 130.1 2.7e-30 XP_011516826 (OMIM: 610180) PREDICTED: osteoclast- ( 188) 1253 115.9 4.4e-26 XP_006717118 (OMIM: 610180) PREDICTED: osteoclast- ( 171) 1144 107.0 2e-23 XP_016870111 (OMIM: 610180) PREDICTED: osteoclast- ( 181) 1132 106.0 4e-23 XP_011516827 (OMIM: 610180) PREDICTED: osteoclast- ( 184) 1116 104.8 9.8e-23 >>NP_036515 (OMIM: 610180) osteoclast-stimulating factor (214 aa) initn: 1443 init1: 1443 opt: 1443 Z-score: 672.1 bits: 131.4 E(85289): 1.1e-30 Smith-Waterman score: 1443; 100.0% identity (100.0% similar) in 214 aa overlap (1-214:1-214) 10 20 30 40 50 60 pF1KB6 MSKPPPKPVKPGQVKVFRALYTFEPRTPDELYFEEGDIIYITDMSDTNWWKGTSKGRTGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 MSKPPPKPVKPGQVKVFRALYTFEPRTPDELYFEEGDIIYITDMSDTNWWKGTSKGRTGL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 IPSNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 IPSNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 IVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_036 IVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMA 130 140 150 160 170 180 190 200 210 pF1KB6 TNAACASLLKKKQGTDAVRTLSNAEDYLDDEDSD :::::::::::::::::::::::::::::::::: NP_036 TNAACASLLKKKQGTDAVRTLSNAEDYLDDEDSD 190 200 210 >>XP_006717116 (OMIM: 610180) PREDICTED: osteoclast-stim (217 aa) initn: 1376 init1: 1376 opt: 1427 Z-score: 665.0 bits: 130.1 E(85289): 2.7e-30 Smith-Waterman score: 1427; 98.6% identity (98.6% similar) in 217 aa overlap (1-214:1-217) 10 20 30 40 50 pF1KB6 MSKPPPKPVKPG---QVKVFRALYTFEPRTPDELYFEEGDIIYITDMSDTNWWKGTSKGR :::::::::::: ::::::::::::::::::::::::::::::::::::::::::::: XP_006 MSKPPPKPVKPGEGGQVKVFRALYTFEPRTPDELYFEEGDIIYITDMSDTNWWKGTSKGR 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 TGLIPSNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TGLIPSNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGG 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB6 HKDIVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HKDIVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAF 130 140 150 160 170 180 180 190 200 210 pF1KB6 DMATNAACASLLKKKQGTDAVRTLSNAEDYLDDEDSD ::::::::::::::::::::::::::::::::::::: XP_006 DMATNAACASLLKKKQGTDAVRTLSNAEDYLDDEDSD 190 200 210 >>XP_011516826 (OMIM: 610180) PREDICTED: osteoclast-stim (188 aa) initn: 1253 init1: 1253 opt: 1253 Z-score: 589.2 bits: 115.9 E(85289): 4.4e-26 Smith-Waterman score: 1253; 100.0% identity (100.0% similar) in 187 aa overlap (28-214:2-188) 10 20 30 40 50 60 pF1KB6 MSKPPPKPVKPGQVKVFRALYTFEPRTPDELYFEEGDIIYITDMSDTNWWKGTSKGRTGL ::::::::::::::::::::::::::::::::: XP_011 MPDELYFEEGDIIYITDMSDTNWWKGTSKGRTGL 10 20 30 70 80 90 100 110 120 pF1KB6 IPSNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IPSNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKD 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB6 IVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMA 100 110 120 130 140 150 190 200 210 pF1KB6 TNAACASLLKKKQGTDAVRTLSNAEDYLDDEDSD :::::::::::::::::::::::::::::::::: XP_011 TNAACASLLKKKQGTDAVRTLSNAEDYLDDEDSD 160 170 180 >>XP_006717118 (OMIM: 610180) PREDICTED: osteoclast-stim (171 aa) initn: 1144 init1: 1144 opt: 1144 Z-score: 541.7 bits: 107.0 E(85289): 2e-23 Smith-Waterman score: 1144; 100.0% identity (100.0% similar) in 171 aa overlap (44-214:1-171) 20 30 40 50 60 70 pF1KB6 VKVFRALYTFEPRTPDELYFEEGDIIYITDMSDTNWWKGTSKGRTGLIPSNYVAEQAESI :::::::::::::::::::::::::::::: XP_006 MSDTNWWKGTSKGRTGLIPSNYVAEQAESI 10 20 30 80 90 100 110 120 130 pF1KB6 DNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIEL 40 50 60 70 80 90 140 150 160 170 180 190 pF1KB6 NQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATNAACASLLKKKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATNAACASLLKKKQ 100 110 120 130 140 150 200 210 pF1KB6 GTDAVRTLSNAEDYLDDEDSD ::::::::::::::::::::: XP_006 GTDAVRTLSNAEDYLDDEDSD 160 170 >>XP_016870111 (OMIM: 610180) PREDICTED: osteoclast-stim (181 aa) initn: 1176 init1: 1119 opt: 1132 Z-score: 536.2 bits: 106.0 E(85289): 4e-23 Smith-Waterman score: 1161; 84.6% identity (84.6% similar) in 214 aa overlap (1-214:1-181) 10 20 30 40 50 60 pF1KB6 MSKPPPKPVKPGQVKVFRALYTFEPRTPDELYFEEGDIIYITDMSDTNWWKGTSKGRTGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSKPPPKPVKPGQVKVFRALYTFEPRTPDELYFEEGDIIYITDMSDTNWWKGTSKGRTGL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 IPSNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IPSNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 IVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMA :::::::::::::::::::::::::::::::::::::::::: XP_016 IVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAK------------------ 130 140 150 160 190 200 210 pF1KB6 TNAACASLLKKKQGTDAVRTLSNAEDYLDDEDSD ::::::::::::::::::: XP_016 ---------------DAVRTLSNAEDYLDDEDSD 170 180 >>XP_011516827 (OMIM: 610180) PREDICTED: osteoclast-stim (184 aa) initn: 1183 init1: 1045 opt: 1116 Z-score: 529.1 bits: 104.8 E(85289): 9.8e-23 Smith-Waterman score: 1145; 83.4% identity (83.4% similar) in 217 aa overlap (1-214:1-184) 10 20 30 40 50 pF1KB6 MSKPPPKPVKPG---QVKVFRALYTFEPRTPDELYFEEGDIIYITDMSDTNWWKGTSKGR :::::::::::: ::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSKPPPKPVKPGEGGQVKVFRALYTFEPRTPDELYFEEGDIIYITDMSDTNWWKGTSKGR 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 TGLIPSNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TGLIPSNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGG 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB6 HKDIVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNIEKKLAF ::::::::::::::::::::::::::::::::::::::::::::: XP_011 HKDIVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLLAK--------------- 130 140 150 160 180 190 200 210 pF1KB6 DMATNAACASLLKKKQGTDAVRTLSNAEDYLDDEDSD ::::::::::::::::::: XP_011 ------------------DAVRTLSNAEDYLDDEDSD 170 180 214 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 11:15:29 2016 done: Fri Nov 4 11:15:30 2016 Total Scan time: 4.590 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]