Result of FASTA (omim) for
pF1KB6964
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6964, 241 aa
1>>>pF1KB6964 241 - 241 aa - 241 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.7254+/-0.000385; mu= 17.2390+/- 0.024
mean_var=59.7963+/-12.220, 0's: 0 Z-trim(111.6): 32 B-trim: 5 in 1/50
Lambda= 0.165858
statistics sampled from 20200 (20225) to 20200 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.605), E-opt: 0.2 (0.237), width: 16
Scan time: 5.520
The best scores are: opt bits E(85289)
NP_002784 (OMIM: 602017) proteasome subunit beta t ( 241) 1577 385.8 3.7e-107
NP_002786 (OMIM: 602176) proteasome subunit beta t ( 205) 287 77.0 2.7e-14
NP_002785 (OMIM: 602175) proteasome subunit beta t ( 201) 223 61.7 1.1e-09
NP_002787 (OMIM: 602177) proteasome subunit beta t ( 264) 190 53.9 3.2e-07
NP_001186708 (OMIM: 602175) proteasome subunit bet ( 176) 166 48.0 1.3e-05
NP_001257410 (OMIM: 600307) proteasome subunit bet ( 213) 166 48.1 1.5e-05
NP_002789 (OMIM: 600307) proteasome subunit beta t ( 239) 166 48.1 1.6e-05
NP_001093250 (OMIM: 611137) proteasome subunit bet ( 300) 157 46.0 8.5e-05
NP_002788 (OMIM: 600306) proteasome subunit beta t ( 263) 154 45.3 0.00013
NP_002790 (OMIM: 604030) proteasome subunit beta t ( 277) 150 44.3 0.00026
NP_004150 (OMIM: 177046,256040) proteasome subunit ( 272) 149 44.1 0.0003
NP_683720 (OMIM: 177046,256040) proteasome subunit ( 276) 149 44.1 0.0003
NP_002792 (OMIM: 176847) proteasome subunit beta t ( 273) 147 43.6 0.00041
XP_005267928 (OMIM: 600306) PREDICTED: proteasome ( 169) 134 40.4 0.0025
NP_002782 (OMIM: 602855,608446) proteasome subunit ( 246) 131 39.8 0.0054
NP_001138404 (OMIM: 600306) proteasome subunit bet ( 203) 129 39.2 0.0065
>>NP_002784 (OMIM: 602017) proteasome subunit beta type- (241 aa)
initn: 1577 init1: 1577 opt: 1577 Z-score: 2044.8 bits: 385.8 E(85289): 3.7e-107
Smith-Waterman score: 1577; 100.0% identity (100.0% similar) in 241 aa overlap (1-241:1-241)
10 20 30 40 50 60
pF1KB6 MLSSTAMYSAPGRDLGMEPHRAAGPLQLRFSPYVFNGGTILAIAGEDFAIVASDTRLSEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MLSSTAMYSAPGRDLGMEPHRAAGPLQLRFSPYVFNGGTILAIAGEDFAIVASDTRLSEG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 FSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 FSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAML
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 STILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 STILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 VGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVSLRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 VGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVSLRK
190 200 210 220 230 240
pF1KB6 D
:
NP_002 D
>>NP_002786 (OMIM: 602176) proteasome subunit beta type- (205 aa)
initn: 224 init1: 224 opt: 287 Z-score: 377.5 bits: 77.0 E(85289): 2.7e-14
Smith-Waterman score: 287; 25.8% identity (64.1% similar) in 209 aa overlap (35-241:6-205)
10 20 30 40 50 60
pF1KB6 TAMYSAPGRDLGMEPHRAAGPLQLRFSPYVFNGGTILAIAGEDFAIVASDTRLSEGFSIH
.:::...:. :.. . .:.: :.. ..
NP_002 MSIMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMV
10 20 30
70 80 90 100 110 120
pF1KB6 TRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAMLSTIL
: : : . . :. :: .:. : :... .. ::..:. .... . .. .:....:
NP_002 TTDFQKIFPMGDRLYIGLAGLATDVQTVAQRLKFRLNLYELKEGRQIKPYTLMSMVANLL
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB6 YSRRFFPYYVYNIIGGLDEEG-KGAVYSFDPVGSYQ-RDSFKAGGSASAMLQPLLDNQVG
: .:: :::. .:.::: . : . :.: .: . :.: ..:. . .. . .. .
NP_002 YEKRFGPYYTEPVIAGLDPKTFKPFICSLDLIGCPMVTDDFVVSGTCAEQMYGMCES-LW
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB6 FKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVSLRKD
:: . .:. ....:: ..:..::. .: .. . :. :. : .:.. : :
NP_002 EPNM-DPDHLFETISQAM-------LNAVDRDAVSGMGVIVHIIEKDKITTRTLKARMD
160 170 180 190 200
>>NP_002785 (OMIM: 602175) proteasome subunit beta type- (201 aa)
initn: 175 init1: 107 opt: 223 Z-score: 294.9 bits: 61.7 E(85289): 1.1e-09
Smith-Waterman score: 223; 25.0% identity (58.7% similar) in 208 aa overlap (40-240:4-198)
10 20 30 40 50 60
pF1KB6 APGRDLGMEPHRAAGPLQLRFSPYVFNGGTILAIAGEDFAIVASDTRLSEGFSIHTRDS-
...: : :...:::: :.. . .. .:.
NP_002 MEYLIGIQGPDYVLVASD-RVAASNIVQMKDDH
10 20 30
70 80 90 100 110 120
pF1KB6 PKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAM----LSTIL
: .:...: .. : : :: . ... :. ...:: :. .. : : . :. :
NP_002 DKMFKMSEKILLLCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADCL
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB6 YSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQVGFK
:: ::.: ...: ::. :.: .: ... . : : : .. . .::
NP_002 RSRT--PYHVNLLLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRY----
100 110 120 130 140
190 200 210 220 230 240
pF1KB6 NMQNVEHVP-LSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIRE-ETVSLRKD
..: .: .::..:.. . .: . . .. . :. :.::.. ...:. :
NP_002 ------YTPTISRERAVELLRKCLEELQKRFILNLPTFSVRIIDKNGIHDLDNISFPKQG
150 160 170 180 190 200
NP_002 S
>>NP_002787 (OMIM: 602177) proteasome subunit beta type- (264 aa)
initn: 100 init1: 48 opt: 190 Z-score: 250.6 bits: 53.9 E(85289): 3.2e-07
Smith-Waterman score: 190; 25.5% identity (55.7% similar) in 235 aa overlap (8-234:22-245)
10 20 30 40
pF1KB6 MLSSTAMYSAPGR-DLGMEPHRAA--GPLQLRFSPYVFNGGTILAI
: :. : :.: : ::. .:.: .: ..:..
NP_002 MEAFLGSRSGLWAGGPAPGQFYRIPSTPDSFMDPASALYRGPITRTQNPMV-TGTSVLGV
10 20 30 40 50
50 60 70 80 90 100
pF1KB6 AGEDFAIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKII-EARLKM
: ...:.: : : . :. . ......:..: :: ..: : ... . .
NP_002 KFEGGVVIAADMLGSYGSLARFRNISRIMRVNNSTMLGASGDYADFQYLKQVLGQMVIDE
60 70 80 90 100 110
110 120 130 140 150
pF1KB6 YKHSNNKAMTTGAIAAMLSTILYSRR--FFPYYVYNIIGGLDEEGKGAVYSFDPVG-SYQ
....... :: . :. .:::: . : . .::: .:.. . : .: .:.
NP_002 ELLGDGHSYSPRAIHSWLTRAMYSRRSKMNPLWNTMVIGGY-ADGESFLGYVDMLGVAYE
120 130 140 150 160 170
160 170 180 190 200 210
pF1KB6 RDSFKAGGSASAMLQPLLDNQVGFKNMQNVEHVP-LSLDRAMRLVKDVFISAAERDVYTG
:. : : .. . :::: . .:. : :: .: ::. . ::. .
NP_002 APSL-ATGYGAYLAQPLLR--------EVLEKQPVLSQTEARDLVERCMRVLYYRDARSY
180 190 200 210 220
220 230 240
pF1KB6 DALRICIVTKEGIREETVSLRKD
. ..: ::..:.. :
NP_002 NRFQIATVTEKGVEIEGPLSTETNWDIAHMISGFE
230 240 250 260
>>NP_001186708 (OMIM: 602175) proteasome subunit beta ty (176 aa)
initn: 122 init1: 82 opt: 166 Z-score: 222.0 bits: 48.0 E(85289): 1.3e-05
Smith-Waterman score: 186; 24.4% identity (56.1% similar) in 180 aa overlap (67-240:6-173)
40 50 60 70 80 90
pF1KB6 GGTILAIAGEDFAIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKII
: : .:...: .. : : :: . ... :
NP_001 MEYLIDHDKMFKMSEKILLLCVGEAGDTVQFAEYI
10 20 30
100 110 120 130 140 150
pF1KB6 EARLKMYKHSNNKAMTTGAIAAM----LSTILYSRRFFPYYVYNIIGGLDEEGKGAVYSF
. ...:: :. .. : : . :. : :: ::.: ...: ::. :.: .
NP_001 QKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRT--PYHVNLLLAGYDEHEGPALYYM
40 50 60 70 80 90
160 170 180 190 200 210
pF1KB6 DPVGSYQRDSFKAGGSASAMLQPLLDNQVGFKNMQNVEHVP-LSLDRAMRLVKDVFISAA
: ... . : : : .. . .:: ..: .: .::..:.. .
NP_001 DYLAALAKAPFAAHGYGAFLTLSILDRY----------YTPTISRERAVELLRKCLEELQ
100 110 120 130 140
220 230 240
pF1KB6 ERDVYTGDALRICIVTKEGIRE-ETVSLRKD
.: . . .. . :. :.::.. ...:. :
NP_001 KRFILNLPTFSVRIIDKNGIHDLDNISFPKQGS
150 160 170
>>NP_001257410 (OMIM: 600307) proteasome subunit beta ty (213 aa)
initn: 124 init1: 91 opt: 166 Z-score: 220.8 bits: 48.1 E(85289): 1.5e-05
Smith-Waterman score: 166; 27.1% identity (55.9% similar) in 170 aa overlap (16-178:10-174)
10 20 30 40 50
pF1KB6 MLSSTAMYSAPGRDLGMEPHRAAGPLQLRFSP-----YVFNGGTILAIAGEDFAIVASDT
: : : :: :.: : .: ::.:. . .....:.
NP_001 MAATLLAARGAGPAPAWGPEA--FTPDWESREVSTGTTIMAVQFDGGVVLGADS
10 20 30 40 50
60 70 80 90 100 110
pF1KB6 RLSEGFSIHTRDSPKCYKLTDKTVIGC-SGFHGDCLTLTKIIEARLKMYKHSNNKAMTTG
: . : : .: . : . :. .. : :: .: ... . .: ... :. .
NP_001 RTTTGSYIANRVTDKLTPIHDR-IFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVH
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB6 AIAAMLSTILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQ-RDSFKAGGSASAML
. :.... . : : .. ::.: : . : ::: :.:... :.:: :::.:...
NP_001 TAASLFKEMCYRYRE-DLMAGIIIAGWDPQEGGQVYSV-PMGGMMVRQSFAIGGSGSSYI
120 130 140 150 160
180 190 200 210 220 230
pF1KB6 QPLLDNQVGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIRE
.:
NP_001 YGYVDATYREGMTKEECLQFTANAFFFYPQLSLWPWSGMAPVEE
170 180 190 200 210
>>NP_002789 (OMIM: 600307) proteasome subunit beta type- (239 aa)
initn: 127 init1: 91 opt: 166 Z-score: 220.1 bits: 48.1 E(85289): 1.6e-05
Smith-Waterman score: 193; 23.2% identity (56.6% similar) in 228 aa overlap (16-236:10-223)
10 20 30 40 50
pF1KB6 MLSSTAMYSAPGRDLGMEPHRAAGPLQLRFSP-----YVFNGGTILAIAGEDFAIVASDT
: : : :: :.: : .: ::.:. . .....:.
NP_002 MAATLLAARGAGPAPAWGPEA--FTPDWESREVSTGTTIMAVQFDGGVVLGADS
10 20 30 40 50
60 70 80 90 100 110
pF1KB6 RLSEGFSIHTRDSPKCYKLTDKTVIGC-SGFHGDCLTLTKIIEARLKMYKHSNNKAMTTG
: . : : .: . : . :. .. : :: .: ... . .: ... :. .
NP_002 RTTTGSYIANRVTDKLTPIHDR-IFCCRSGSAADTQAVADAVTYQLGFHSIELNEPPLVH
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB6 AIAAMLSTILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQ-RDSFKAGGSASAML
. :.... . : : .. ::.: : . : ::: :.:... :.:: :::.:...
NP_002 TAASLFKEMCYRYRE-DLMAGIIIAGWDPQEGGQVYSV-PMGGMMVRQSFAIGGSGSSYI
120 130 140 150 160
180 190 200 210 220 230
pF1KB6 QPLLDNQVGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIRE
.: ... .. .. .... ... : ::: .: ..:. ... :...
NP_002 YGYVDAT--YRE-------GMTKEECLQFTANALALAMERDGSSGGVIRLAAIAESGVER
170 180 190 200 210 220
240
pF1KB6 ETVSLRKD
...
NP_002 QVLLGDQIPKFAVATLPPA
230
>>NP_001093250 (OMIM: 611137) proteasome subunit beta ty (300 aa)
initn: 96 init1: 96 opt: 157 Z-score: 207.1 bits: 46.0 E(85289): 8.5e-05
Smith-Waterman score: 185; 24.4% identity (53.8% similar) in 221 aa overlap (13-230:23-232)
10 20 30 40
pF1KB6 MLSSTAMYSAPGRDLGMEPHRAAGP---LQLRFSPYVFNGGTILAIAGED
: : :. : ::.. .: . .: : ::. .
NP_001 MALQDVCKWQSPDTQGPSPHLPRAGGWAVPRGCDPQTFLQIH-GPRLAHGTTTLAFRFRH
10 20 30 40 50
50 60 70 80 90 100
pF1KB6 FAIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSN
.:.:.::: : : . : : . .. . :: .:: : .... .:.. . .
NP_001 GVIAAADTRSSCGSYVACPASCKVIPVHQHLLGTTSGTSADCATWYRVLQRELRLRELRE
60 70 80 90 100 110
110 120 130 140 150 160
pF1KB6 NKAMTTGAIAAMLSTILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGG
.. .... : .::... . : . : . . : :. : : .. : : :..:
NP_001 GQLPSVASAAKLLSAMMSQYRGLDLCVATALCGWDRSGPELFYVYSDGTRLQGDIFSVG-
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB6 SASAMLQPLLDNQVGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVT
:.: . .:: :.. .: ..:. :.. . :..::.:.: .. . :
NP_001 SGSPYAYGVLDR--GYR-------YDMSTQEAYALARCAVAHATHRDAYSGGSVDLFHVR
180 190 200 210 220
230 240
pF1KB6 KEGIREETVSLRKD
. :
NP_001 ESGWEHVSRSDACVLYVELQKLLEPEPEEDASHAHPEPATAHRAAEDRELSVGPGEVTPG
230 240 250 260 270 280
>>NP_002788 (OMIM: 600306) proteasome subunit beta type- (263 aa)
initn: 70 init1: 70 opt: 154 Z-score: 204.0 bits: 45.3 E(85289): 0.00013
Smith-Waterman score: 189; 21.8% identity (57.9% similar) in 197 aa overlap (34-230:56-242)
10 20 30 40 50 60
pF1KB6 STAMYSAPGRDLGMEPHRAAGPLQLRFSPYVFNGGTILAIAGEDFAIVASDTRLSEGFSI
...: : ::. . .:::.:.: . : :
NP_002 DLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYI
30 40 50 60 70 80
70 80 90 100 110 120
pF1KB6 HTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAMLSTI
.. : ... . .: .:: ... . ..:. :.. ....: . .:...
NP_002 ASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANM
90 100 110 120 130 140
130 140 150 160 170 180
pF1KB6 LYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQVGF
.:. . . . ..: : :..: : .: : :. . . ::.:.. ..: ..
NP_002 VYQYKGMGLSMGTMICGWDKRGPG-LYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSY
150 160 170 180 190 200
190 200 210 220 230 240
pF1KB6 KNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVSLRKD
: ...:. :.. .. .:. ::.:.: :. . : ..:
NP_002 ---------DLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLH
210 220 230 240 250
NP_002 EKYSGSTP
260
>>NP_002790 (OMIM: 604030) proteasome subunit beta type- (277 aa)
initn: 118 init1: 91 opt: 150 Z-score: 198.5 bits: 44.3 E(85289): 0.00026
Smith-Waterman score: 180; 21.5% identity (56.6% similar) in 251 aa overlap (2-240:1-238)
10 20 30 40 50
pF1KB6 MLSSTAMYSAPGRDLGMEPHRAAGPLQLRFS------PYVFNGGTILA-IAGEDFAIVAS
......:. : .... : . :. :. : : . :: .: .. .: ....
NP_002 MAAVSVYAPPVGGFSFDNCRRNAVLEADFAKRGYKLPKVRKTGTTIAGVVYKDGIVLGA
10 20 30 40 50
60 70 80 90 100 110
pF1KB6 DTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTT
::: .::. . .. : . .. . .: .: :..: . :.... :... .
NP_002 DTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRV
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB6 GAIAAMLSTILYSRRFFPYY-VYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAM
. ::. .:. :. : . ..::.: : .::. : :: .. . . ::.:
NP_002 VTANRMLKQMLF--RYQGYIGAALVLGGVDVTGPH-LYSIYPHGSTDKLPYVTMGSGSLA
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB6 LQPLLDNQVGFK-NMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGI
. ..... :. .:.. : : ::.... .. :. .:. . .:...:. .
NP_002 AMAVFEDK--FRPDMEEEE--------AKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKL
180 190 200 210 220
240
pF1KB6 ---REETVSLRKD
: :: .:
NP_002 DFLRPYTVPNKKGTRLGRYRCEKGTTAVLTEKITPLEIEVLEETVQTMDTS
230 240 250 260 270
241 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 11:16:06 2016 done: Fri Nov 4 11:16:07 2016
Total Scan time: 5.520 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]