FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6984, 247 aa 1>>>pF1KB6984 247 - 247 aa - 247 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2238+/-0.000339; mu= 14.9169+/- 0.021 mean_var=73.3672+/-14.900, 0's: 0 Z-trim(115.7): 312 B-trim: 1170 in 1/50 Lambda= 0.149735 statistics sampled from 26050 (26375) to 26050 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.687), E-opt: 0.2 (0.309), width: 16 Scan time: 5.810 The best scores are: opt bits E(85289) NP_002760 (OMIM: 167800,276000,614044) trypsin-1 p ( 247) 1691 374.3 1.1e-103 XP_011514713 (OMIM: 167800,276000,614044) PREDICTE ( 472) 1691 374.5 1.9e-103 NP_002761 (OMIM: 167800,601564) trypsin-2 isoform ( 247) 1521 337.6 1.3e-92 NP_002762 (OMIM: 613578) trypsin-3 isoform 2 prepr ( 247) 1496 332.2 5.4e-91 NP_001184027 (OMIM: 613578) trypsin-3 isoform 4 pr ( 240) 1437 319.4 3.6e-87 NP_001184026 (OMIM: 613578) trypsin-3 isoform 3 pr ( 261) 1437 319.4 3.8e-87 NP_031369 (OMIM: 613578) trypsin-3 isoform 1 prepr ( 304) 1433 318.6 7.9e-87 XP_011516267 (OMIM: 613578) PREDICTED: trypsin-3 i ( 333) 1428 317.6 1.8e-86 NP_001290343 (OMIM: 167800,601564) trypsin-2 isofo ( 261) 1120 250.9 1.6e-66 NP_001070960 (OMIM: 605643) kallikrein-5 prepropro ( 293) 758 172.8 6e-43 XP_011525004 (OMIM: 605643) PREDICTED: kallikrein- ( 293) 758 172.8 6e-43 NP_001070959 (OMIM: 605643) kallikrein-5 prepropro ( 293) 758 172.8 6e-43 XP_011525005 (OMIM: 605643) PREDICTED: kallikrein- ( 293) 758 172.8 6e-43 NP_036559 (OMIM: 605643) kallikrein-5 preproprotei ( 293) 758 172.8 6e-43 NP_071329 (OMIM: 606135) kallikrein-14 preproprote ( 267) 737 168.2 1.3e-41 NP_001298111 (OMIM: 606135) kallikrein-14 prepropr ( 267) 737 168.2 1.3e-41 NP_009127 (OMIM: 605644) kallikrein-8 isoform 1 pr ( 260) 730 166.7 3.6e-41 NP_659196 (OMIM: 604434) kallikrein-11 isoform 2 [ ( 282) 730 166.7 3.9e-41 NP_653088 (OMIM: 605644) kallikrein-8 isoform 2 pr ( 305) 730 166.7 4.1e-41 NP_001129504 (OMIM: 604434) kallikrein-11 isoform ( 250) 728 166.3 4.7e-41 NP_006844 (OMIM: 604434) kallikrein-11 isoform 1 p ( 250) 728 166.3 4.7e-41 NP_001012982 (OMIM: 602652) kallikrein-6 isoform A ( 244) 726 165.8 6.3e-41 NP_002765 (OMIM: 602652) kallikrein-6 isoform A pr ( 244) 726 165.8 6.3e-41 NP_056411 (OMIM: 605505) kallikrein-13 precursor [ ( 277) 703 160.9 2.2e-39 NP_644806 (OMIM: 604438) kallikrein-7 isoform 1 pr ( 253) 687 157.4 2.2e-38 NP_005037 (OMIM: 604438) kallikrein-7 isoform 1 pr ( 253) 687 157.4 2.2e-38 NP_665901 (OMIM: 605539) kallikrein-12 isoform 2 p ( 248) 670 153.7 2.8e-37 NP_036447 (OMIM: 605504) kallikrein-9 precursor [H ( 250) 660 151.6 1.3e-36 NP_062544 (OMIM: 605539) kallikrein-12 isoform 1 p ( 254) 639 147.0 2.9e-35 NP_004908 (OMIM: 204700,603767) kallikrein-4 isofo ( 254) 632 145.5 8.4e-35 NP_001897 (OMIM: 118890) chymotrypsinogen B isofor ( 263) 607 140.1 3.6e-33 NP_002767 (OMIM: 602673) kallikrein-10 preproprote ( 276) 607 140.1 3.8e-33 XP_005259119 (OMIM: 602673) PREDICTED: kallikrein- ( 276) 607 140.1 3.8e-33 XP_006723350 (OMIM: 602673) PREDICTED: kallikrein- ( 276) 607 140.1 3.8e-33 NP_665895 (OMIM: 602673) kallikrein-10 preproprote ( 276) 607 140.1 3.8e-33 NP_001070968 (OMIM: 602673) kallikrein-10 prepropr ( 276) 607 140.1 3.8e-33 XP_005259118 (OMIM: 602673) PREDICTED: kallikrein- ( 276) 607 140.1 3.8e-33 XP_016882482 (OMIM: 602673) PREDICTED: kallikrein- ( 276) 607 140.1 3.8e-33 XP_006723352 (OMIM: 602673) PREDICTED: kallikrein- ( 276) 607 140.1 3.8e-33 XP_011526284 (OMIM: 610477) PREDICTED: transmembra ( 562) 607 140.4 6.6e-33 XP_011526282 (OMIM: 610477) PREDICTED: transmembra ( 690) 607 140.4 7.7e-33 NP_892018 (OMIM: 610477) transmembrane protease se (1059) 607 140.6 1.1e-32 XP_011526280 (OMIM: 610477) PREDICTED: transmembra (1093) 607 140.6 1.1e-32 NP_001161077 (OMIM: 604434) kallikrein-11 isoform ( 275) 599 138.4 1.2e-32 XP_011524673 (OMIM: 604434) PREDICTED: kallikrein- ( 275) 599 138.4 1.2e-32 XP_011524672 (OMIM: 604434) PREDICTED: kallikrein- ( 275) 599 138.4 1.2e-32 XP_011524675 (OMIM: 604434) PREDICTED: kallikrein- ( 275) 599 138.4 1.2e-32 XP_011524674 (OMIM: 604434) PREDICTED: kallikrein- ( 275) 599 138.4 1.2e-32 XP_011524671 (OMIM: 604434) PREDICTED: kallikrein- ( 307) 599 138.4 1.4e-32 XP_005262454 (OMIM: 122700,300746,300807,306900) P ( 418) 590 136.6 6.7e-32 >>NP_002760 (OMIM: 167800,276000,614044) trypsin-1 prepr (247 aa) initn: 1691 init1: 1691 opt: 1691 Z-score: 1982.3 bits: 374.3 E(85289): 1.1e-103 Smith-Waterman score: 1691; 100.0% identity (100.0% similar) in 247 aa overlap (1-247:1-247) 10 20 30 40 50 60 pF1KB6 MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK 190 200 210 220 230 240 pF1KB6 NTIAANS ::::::: NP_002 NTIAANS >>XP_011514713 (OMIM: 167800,276000,614044) PREDICTED: t (472 aa) initn: 1691 init1: 1691 opt: 1691 Z-score: 1978.4 bits: 374.5 E(85289): 1.9e-103 Smith-Waterman score: 1691; 100.0% identity (100.0% similar) in 247 aa overlap (1-247:226-472) 10 20 30 pF1KB6 MNPLLILTFVAAALAAPFDDDDKIVGGYNC :::::::::::::::::::::::::::::: XP_011 VTLTSQSPPLWILVRYKDESSTTSQAHSTTMNPLLILTFVAAALAAPFDDDDKIVGGYNC 200 210 220 230 240 250 40 50 60 70 80 90 pF1KB6 EENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINA 260 270 280 290 300 310 100 110 120 130 140 150 pF1KB6 AKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASS 320 330 340 350 360 370 160 170 180 190 200 210 pF1KB6 GADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQL 380 390 400 410 420 430 220 230 240 pF1KB6 QGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS ::::::::::::::::::::::::::::::::::::: XP_011 QGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS 440 450 460 470 >>NP_002761 (OMIM: 167800,601564) trypsin-2 isoform 2 pr (247 aa) initn: 1521 init1: 1521 opt: 1521 Z-score: 1783.9 bits: 337.6 E(85289): 1.3e-92 Smith-Waterman score: 1521; 89.5% identity (96.4% similar) in 247 aa overlap (1-247:1-247) 10 20 30 40 50 60 pF1KB6 MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS :: ::::::::::.:::::::::::::: ::::::::::::::::::::::::.:::::: NP_002 MNLLLILTFVAAAVAAPFDDDDKIVGGYICEENSVPYQVSLNSGYHFCGGSLISEQWVVS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN :::::::::::::::::::::::::::::::::::::.:. .::.:::.:::::: :::: NP_002 AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPKYNSRTLDNDILLIKLSSPAVIN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT .:::.:::::::::.::. :::::::: :::::::::::::::::::::.:::::::::: NP_002 SRVSAISLPTAPPAAGTESLISGWGNTLSSGADYPDELQCLDAPVLSQAECEASYPGKIT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK .:::::::::::::::::::::::: ::.:::.:::: ::::::.::::::::::: ::: NP_002 NNMFCVGFLEGGKDSCQGDSGGPVVSNGELQGIVSWGYGCAQKNRPGVYTKVYNYVDWIK 190 200 210 220 230 240 pF1KB6 NTIAANS .:::::: NP_002 DTIAANS >>NP_002762 (OMIM: 613578) trypsin-3 isoform 2 prepropro (247 aa) initn: 1496 init1: 1496 opt: 1496 Z-score: 1754.7 bits: 332.2 E(85289): 5.4e-91 Smith-Waterman score: 1496; 86.6% identity (96.4% similar) in 247 aa overlap (1-247:1-247) 10 20 30 40 50 60 pF1KB6 MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS :::.:::.::.::.:.::::::::::::.:::::.::::::::: ::::::::.:::::: NP_002 MNPFLILAFVGAAVAVPFDDDDKIVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN :.::::.:::::::::::.::::::::::::::::::.:.: ::.:::::::::: :::: NP_002 AAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVIN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT ::::::::::::::.::.::::::::: : ::::::::.:::::::.::.:.:::::::: NP_002 ARVSTISLPTAPPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKIT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK ..::::::::::::::: ::::::::::::::::::: ::: ::.::::::::::: ::: NP_002 NSMFCVGFLEGGKDSCQRDSGGPVVCNGQLQGVVSWGHGCAWKNRPGVYTKVYNYVDWIK 190 200 210 220 230 240 pF1KB6 NTIAANS .:::::: NP_002 DTIAANS >>NP_001184027 (OMIM: 613578) trypsin-3 isoform 4 prepro (240 aa) initn: 1437 init1: 1437 opt: 1437 Z-score: 1686.0 bits: 319.4 E(85289): 3.6e-87 Smith-Waterman score: 1437; 86.5% identity (95.8% similar) in 237 aa overlap (11-247:4-240) 10 20 30 40 50 60 pF1KB6 MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS :. .:.::::::::::::.:::::.::::::::: ::::::::.:::::: NP_001 MGPAGEVAVPFDDDDKIVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVS 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN :.::::.:::::::::::.::::::::::::::::::.:.: ::.:::::::::: :::: NP_001 AAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVIN 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT ::::::::::::::.::.::::::::: : ::::::::.:::::::.::.:.:::::::: NP_001 ARVSTISLPTAPPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKIT 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB6 SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK ..::::::::::::::: ::::::::::::::::::: ::: ::.::::::::::: ::: NP_001 NSMFCVGFLEGGKDSCQRDSGGPVVCNGQLQGVVSWGHGCAWKNRPGVYTKVYNYVDWIK 180 190 200 210 220 230 pF1KB6 NTIAANS .:::::: NP_001 DTIAANS 240 >>NP_001184026 (OMIM: 613578) trypsin-3 isoform 3 prepro (261 aa) initn: 1437 init1: 1437 opt: 1437 Z-score: 1685.5 bits: 319.4 E(85289): 3.8e-87 Smith-Waterman score: 1437; 86.9% identity (95.8% similar) in 236 aa overlap (12-247:26-261) 10 20 30 40 pF1KB6 MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYH : .:.::::::::::::.:::::.::::::::: : NP_001 MHMRETSGFTLKKGRSAPLVFHPPDALIAVPFDDDDKIVGGYTCEENSLPYQVSLNSGSH 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB6 FCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNN :::::::.:::::::.::::.:::::::::::.::::::::::::::::::.:.: ::.: NP_001 FCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDN 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB6 DIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVL ::::::::: ::::::::::::::::::.::.::::::::: : ::::::::.::::::: NP_001 DIMLIKLSSPAVINARVSTISLPTAPPAAGTECLISGWGNTLSFGADYPDELKCLDAPVL 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB6 SQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKP .::.:.::::::::..::::::::::::::: ::::::::::::::::::: ::: ::.: NP_001 TQAECKASYPGKITNSMFCVGFLEGGKDSCQRDSGGPVVCNGQLQGVVSWGHGCAWKNRP 190 200 210 220 230 240 230 240 pF1KB6 GVYTKVYNYVKWIKNTIAANS :::::::::: :::.:::::: NP_001 GVYTKVYNYVDWIKDTIAANS 250 260 >>NP_031369 (OMIM: 613578) trypsin-3 isoform 1 prepropro (304 aa) initn: 1433 init1: 1433 opt: 1433 Z-score: 1679.9 bits: 318.6 E(85289): 7.9e-87 Smith-Waterman score: 1433; 87.2% identity (96.2% similar) in 234 aa overlap (14-247:71-304) 10 20 30 40 pF1KB6 MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNS .:.::::::::::::.:::::.:::::::: NP_031 GGAGLELHPLLGGRTWRAARDADGCEALGTVAVPFDDDDKIVGGYTCEENSLPYQVSLNS 50 60 70 80 90 100 50 60 70 80 90 100 pF1KB6 GYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKT : ::::::::.:::::::.::::.:::::::::::.::::::::::::::::::.:.: : NP_031 GSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDT 110 120 130 140 150 160 110 120 130 140 150 160 pF1KB6 LNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDA :.:::::::::: ::::::::::::::::::.::.::::::::: : ::::::::.:::: NP_031 LDNDIMLIKLSSPAVINARVSTISLPTAPPAAGTECLISGWGNTLSFGADYPDELKCLDA 170 180 190 200 210 220 170 180 190 200 210 220 pF1KB6 PVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQK :::.::.:.::::::::..::::::::::::::: ::::::::::::::::::: ::: : NP_031 PVLTQAECKASYPGKITNSMFCVGFLEGGKDSCQRDSGGPVVCNGQLQGVVSWGHGCAWK 230 240 250 260 270 280 230 240 pF1KB6 NKPGVYTKVYNYVKWIKNTIAANS :.::::::::::: :::.:::::: NP_031 NRPGVYTKVYNYVDWIKDTIAANS 290 300 >>XP_011516267 (OMIM: 613578) PREDICTED: trypsin-3 isofo (333 aa) initn: 1428 init1: 1428 opt: 1428 Z-score: 1673.5 bits: 317.6 E(85289): 1.8e-86 Smith-Waterman score: 1428; 86.8% identity (96.2% similar) in 234 aa overlap (14-247:100-333) 10 20 30 40 pF1KB6 MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNS .:.::::::::::::.:::::.:::::::: XP_011 VFNWLIWKILERERHRGSDYLPIRNQNELGVAVPFDDDDKIVGGYTCEENSLPYQVSLNS 70 80 90 100 110 120 50 60 70 80 90 100 pF1KB6 GYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKT : ::::::::.:::::::.::::.:::::::::::.::::::::::::::::::.:.: : XP_011 GSHFCGGSLISEQWVVSAAHCYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDT 130 140 150 160 170 180 110 120 130 140 150 160 pF1KB6 LNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDA :.:::::::::: ::::::::::::::.:::.::.::::::::: : ::::::::.:::: XP_011 LDNDIMLIKLSSPAVINARVSTISLPTTPPAAGTECLISGWGNTLSFGADYPDELKCLDA 190 200 210 220 230 240 170 180 190 200 210 220 pF1KB6 PVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQK :::.::.:.::::::::..::::::::::::::: ::::::::::::::::::: ::: : XP_011 PVLTQAECKASYPGKITNSMFCVGFLEGGKDSCQRDSGGPVVCNGQLQGVVSWGHGCAWK 250 260 270 280 290 300 230 240 pF1KB6 NKPGVYTKVYNYVKWIKNTIAANS :.::::::::::: :::.:::::: XP_011 NRPGVYTKVYNYVDWIKDTIAANS 310 320 330 >>NP_001290343 (OMIM: 167800,601564) trypsin-2 isoform 1 (261 aa) initn: 1089 init1: 1089 opt: 1120 Z-score: 1315.4 bits: 250.9 E(85289): 1.6e-66 Smith-Waterman score: 1483; 84.7% identity (91.2% similar) in 261 aa overlap (1-247:1-261) 10 20 30 40 50 60 pF1KB6 MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS :: ::::::::::.:::::::::::::: ::::::::::::::::::::::::.:::::: NP_001 MNLLLILTFVAAAVAAPFDDDDKIVGGYICEENSVPYQVSLNSGYHFCGGSLISEQWVVS 10 20 30 40 50 60 70 80 90 100 pF1KB6 AGHCYKS--------------RIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNN ::::::: ::::::::::::::::::::::::::::::.:. .::.: NP_001 AGHCYKSAINSKLSGRGCEYHRIQVRLGEHNIEVLEGNEQFINAAKIIRHPKYNSRTLDN 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB6 DIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVL ::.:::::: ::::.:::.:::::::::.::. :::::::: :::::::::::::::::: NP_001 DILLIKLSSPAVINSRVSAISLPTAPPAAGTESLISGWGNTLSSGADYPDELQCLDAPVL 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB6 SQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKP :::.::::::::::.:::::::::::::::::::::::: ::.:::.:::: ::::::.: NP_001 SQAECEASYPGKITNNMFCVGFLEGGKDSCQGDSGGPVVSNGELQGIVSWGYGCAQKNRP 190 200 210 220 230 240 230 240 pF1KB6 GVYTKVYNYVKWIKNTIAANS :::::::::: :::.:::::: NP_001 GVYTKVYNYVDWIKDTIAANS 250 260 >>NP_001070960 (OMIM: 605643) kallikrein-5 preproprotein (293 aa) initn: 417 init1: 417 opt: 758 Z-score: 892.0 bits: 172.8 E(85289): 6e-43 Smith-Waterman score: 758; 46.4% identity (77.7% similar) in 233 aa overlap (19-247:62-293) 10 20 30 40 pF1KB6 MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSL--NSGYH :....:..: .:. .. :.:..: . NP_001 DVSCDHPSNTVPSGSNQDLGAGAGEDARSDDSSSRIINGSDCDMHTQPWQAALLLRPNQL 40 50 60 70 80 90 50 60 70 80 90 100 pF1KB6 FCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIE-VLEGNEQFINAAKIIRHPQYDRKTLN .::. :.. ::...:.:: :. ..::::.... : :...:.....: : :: :.. . NP_001 YCGAVLVHPQWLLTAAHCRKKVFRVRLGHYSLSPVYESGQQMFQGVKSIPHPGYSHPGHS 100 110 120 130 140 150 110 120 130 140 150 160 pF1KB6 NDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPV ::.:::::. : . : :.. . :..:::::.::::.: : . .: ::::. : NP_001 NDLMLIKLNRRIRPTKDVRPINVSSHCPSAGTKCLVSGWGTTKSPQVHFPKVLQCLNISV 160 170 180 190 200 210 170 180 190 200 210 220 pF1KB6 LSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGD-GCAQKN ::: .:: .:: .: ..:::.: ..:.:::::::::::::::.:::.::::: ::. : NP_001 LSQKRCEDAYPRQIDDTMFCAG-DKAGRDSCQGDSGGPVVCNGSLQGLVSWGDYPCARPN 220 230 240 250 260 270 230 240 pF1KB6 KPGVYTKVYNYVKWIKNTIAANS .:::::.. ...:::..:: ::: NP_001 RPGVYTNLCKFTKWIQETIQANS 280 290 247 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 10:27:15 2016 done: Fri Nov 4 10:27:16 2016 Total Scan time: 5.810 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]