FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6997, 211 aa 1>>>pF1KB6997 211 - 211 aa - 211 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4049+/-0.000294; mu= 14.2365+/- 0.018 mean_var=75.5375+/-15.227, 0's: 0 Z-trim(119.2): 35 B-trim: 33 in 1/53 Lambda= 0.147568 statistics sampled from 32847 (32882) to 32847 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.752), E-opt: 0.2 (0.386), width: 16 Scan time: 6.570 The best scores are: opt bits E(85289) XP_011513081 (OMIM: 600516) PREDICTED: bcl-2 homol ( 211) 1388 304.0 1.2e-82 NP_001179 (OMIM: 600516) bcl-2 homologous antagoni ( 211) 1388 304.0 1.2e-82 XP_011513082 (OMIM: 600516) PREDICTED: bcl-2 homol ( 152) 992 219.6 2.2e-57 NP_000648 (OMIM: 151430) apoptosis regulator Bcl-2 ( 205) 231 57.6 1.7e-08 NP_000624 (OMIM: 151430) apoptosis regulator Bcl-2 ( 239) 225 56.4 4.5e-08 XP_016881406 (OMIM: 151430) PREDICTED: apoptosis r ( 198) 217 54.6 1.3e-07 XP_011524437 (OMIM: 151430) PREDICTED: apoptosis r ( 224) 217 54.7 1.4e-07 NP_620116 (OMIM: 600040) apoptosis regulator BAX i ( 192) 209 52.9 4e-07 NP_001309169 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 210 53.2 4.1e-07 NP_001304848 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 210 53.2 4.1e-07 NP_001304849 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 210 53.2 4.1e-07 NP_001309171 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 210 53.2 4.1e-07 NP_612815 (OMIM: 600039) bcl-2-like protein 1 isof ( 233) 210 53.2 4.1e-07 XP_011527266 (OMIM: 600039) PREDICTED: bcl-2-like ( 233) 210 53.2 4.1e-07 NP_001309168 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 210 53.2 4.1e-07 NP_001304850 (OMIM: 600039) bcl-2-like protein 1 i ( 233) 210 53.2 4.1e-07 XP_016883482 (OMIM: 600039) PREDICTED: bcl-2-like ( 233) 210 53.2 4.1e-07 NP_004315 (OMIM: 600040) apoptosis regulator BAX i ( 218) 208 52.8 5.2e-07 XP_016882566 (OMIM: 600040) PREDICTED: apoptosis r ( 173) 205 52.0 6.7e-07 NP_001186768 (OMIM: 601931) bcl-2-like protein 2 [ ( 193) 205 52.1 7.3e-07 NP_004041 (OMIM: 601931) bcl-2-like protein 2 [Hom ( 193) 205 52.1 7.3e-07 NP_620119 (OMIM: 600040) apoptosis regulator BAX i ( 179) 204 51.8 8e-07 NP_001278357 (OMIM: 600040) apoptosis regulator BA ( 221) 202 51.5 1.3e-06 NP_001278358 (OMIM: 600040) apoptosis regulator BA ( 181) 198 50.6 1.9e-06 NP_068779 (OMIM: 159552) induced myeloid leukemia ( 350) 185 48.0 2.2e-05 NP_001184249 (OMIM: 159552) induced myeloid leukem ( 197) 180 46.8 3e-05 XP_011509998 (OMIM: 605404) PREDICTED: bcl-2-relat ( 212) 171 44.9 0.00012 NP_115904 (OMIM: 605404) bcl-2-related ovarian kil ( 212) 171 44.9 0.00012 NP_001108207 (OMIM: 601056) bcl-2-related protein ( 163) 167 43.9 0.00017 NP_004040 (OMIM: 601056) bcl-2-related protein A1 ( 175) 167 44.0 0.00018 NP_001278360 (OMIM: 600040) apoptosis regulator BA ( 114) 158 41.9 0.00049 NP_620118 (OMIM: 600040) apoptosis regulator BAX i ( 143) 158 42.0 0.00059 NP_001278359 (OMIM: 600040) apoptosis regulator BA ( 140) 157 41.8 0.00067 XP_016860265 (OMIM: 605404) PREDICTED: bcl-2-relat ( 134) 150 40.3 0.0018 XP_016860264 (OMIM: 605404) PREDICTED: bcl-2-relat ( 134) 150 40.3 0.0018 >>XP_011513081 (OMIM: 600516) PREDICTED: bcl-2 homologou (211 aa) initn: 1388 init1: 1388 opt: 1388 Z-score: 1604.8 bits: 304.0 E(85289): 1.2e-82 Smith-Waterman score: 1388; 97.2% identity (100.0% similar) in 211 aa overlap (1-211:1-211) 10 20 30 40 50 60 pF1KB6 MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYHHQQEQEAEGAAAPADPEM :::::::::::::::::::::::::::::::::::::::::.:::::::::.:::::::: XP_011 MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 VTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIASSLFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::: XP_011 VTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 SGINWGRVVALLGFSYRLALHIYQRGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAA ::::::::::::::.::::::.::.::::::::::::::::::::::::::::::::::: XP_011 SGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAA 130 140 150 160 170 180 190 200 210 pF1KB6 LNLGNGPILNVLVVLGVVLLGQFVVRRFFKS ::::::::::::::::::::::::::::::: XP_011 LNLGNGPILNVLVVLGVVLLGQFVVRRFFKS 190 200 210 >>NP_001179 (OMIM: 600516) bcl-2 homologous antagonist/k (211 aa) initn: 1388 init1: 1388 opt: 1388 Z-score: 1604.8 bits: 304.0 E(85289): 1.2e-82 Smith-Waterman score: 1388; 97.2% identity (100.0% similar) in 211 aa overlap (1-211:1-211) 10 20 30 40 50 60 pF1KB6 MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYHHQQEQEAEGAAAPADPEM :::::::::::::::::::::::::::::::::::::::::.:::::::::.:::::::: NP_001 MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 VTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIASSLFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::: NP_001 VTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 SGINWGRVVALLGFSYRLALHIYQRGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAA ::::::::::::::.::::::.::.::::::::::::::::::::::::::::::::::: NP_001 SGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAA 130 140 150 160 170 180 190 200 210 pF1KB6 LNLGNGPILNVLVVLGVVLLGQFVVRRFFKS ::::::::::::::::::::::::::::::: NP_001 LNLGNGPILNVLVVLGVVLLGQFVVRRFFKS 190 200 210 >>XP_011513082 (OMIM: 600516) PREDICTED: bcl-2 homologou (152 aa) initn: 992 init1: 992 opt: 992 Z-score: 1151.2 bits: 219.6 E(85289): 2.2e-57 Smith-Waterman score: 992; 97.4% identity (100.0% similar) in 152 aa overlap (60-211:1-152) 30 40 50 60 70 80 pF1KB6 DTEEVFRSYVFYHHQQEQEAEGAAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRY :::::::::::::::::::::::::::::: XP_011 MVTLPLQPSSTMGQVGRQLAIIGDDINRRY 10 20 30 90 100 110 120 130 140 pF1KB6 DSEFQTMLQHLQPTAENAYEYFTKIASSLFESGINWGRVVALLGFSYRLALHIYQRGLTG ::::::::::::::::::::::::::.::::::::::::::::::.::::::.::.:::: XP_011 DSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGRVVALLGFGYRLALHVYQHGLTG 40 50 60 70 80 90 150 160 170 180 190 200 pF1KB6 FLGQVTRFVVDFMLHHCIARWIAQRGGWVAALNLGNGPILNVLVVLGVVLLGQFVVRRFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLGQVTRFVVDFMLHHCIARWIAQRGGWVAALNLGNGPILNVLVVLGVVLLGQFVVRRFF 100 110 120 130 140 150 210 pF1KB6 KS :: XP_011 KS >>NP_000648 (OMIM: 151430) apoptosis regulator Bcl-2 bet (205 aa) initn: 267 init1: 152 opt: 231 Z-score: 273.7 bits: 57.6 E(85289): 1.7e-08 Smith-Waterman score: 242; 28.6% identity (57.1% similar) in 175 aa overlap (7-181:46-199) 10 20 30 pF1KB6 MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFR :: .. :. :.::.. ::. . NP_000 MKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSP---- 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB6 SYVFYHHQQEQEAEGAAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTM : : :::: : . .: :. :.: ::..::: .: : NP_000 -------LQTPAAPGAAA--GPALSPVPPVVHLTLRQAG-------DDFSRRYRRDFAEM 80 90 100 110 100 110 120 130 140 150 pF1KB6 LQHLQPTAENAYEYFTKIASSLFESGINWGRVVALLGFSYRLALHIYQRGLTGFLGQVTR ..:. : .: :. .. ::..:.::::.::.. :. . .. .: .. .. ... NP_000 SSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIAL 120 130 140 150 160 170 160 170 180 190 200 210 pF1KB6 FVVDFMLHHCIARWIAQRGGWVAALNLGNGPILNVLVVLGVVLLGQFVVRRFFKS ...... .: . :: . ::::.:: NP_000 WMTEYLNRH-LHTWIQDNGGWVGALGDVSLG 180 190 200 >>NP_000624 (OMIM: 151430) apoptosis regulator Bcl-2 alp (239 aa) initn: 254 init1: 152 opt: 225 Z-score: 265.9 bits: 56.4 E(85289): 4.5e-08 Smith-Waterman score: 236; 28.0% identity (55.9% similar) in 186 aa overlap (7-192:46-209) 10 20 30 pF1KB6 MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFR :: .. :. :.::.. ::. . NP_000 MKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSP---- 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB6 SYVFYHHQQEQEAEGAAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTM : : :::: : . .: :. :.: ::..::: .: : NP_000 -------LQTPAAPGAAA--GPALSPVPPVVHLTLRQAG-------DDFSRRYRRDFAEM 80 90 100 110 100 110 120 130 140 150 pF1KB6 LQHLQPTAENAYEYFTKIASSLFESGINWGRVVALLGFSYRLALHIYQRGLTGFLGQVTR ..:. : .: :. .. ::..:.::::.::.. :. . .. .: .. .. ... NP_000 SSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIAL 120 130 140 150 160 170 160 170 180 190 200 210 pF1KB6 FVVDFMLHHCIARWIAQRGGWVAALNLGNGPILNVLVVLGVVLLGQFVVRRFFKS ...... .: . :: . ::: : ..: :: . : NP_000 WMTEYLNRH-LHTWIQDNGGWDAFVEL-YGPSMRPLFDFSWLSLKTLLSLALVGACITLG 180 190 200 210 220 230 NP_000 AYLGHK >>XP_016881406 (OMIM: 151430) PREDICTED: apoptosis regul (198 aa) initn: 251 init1: 152 opt: 217 Z-score: 257.8 bits: 54.6 E(85289): 1.3e-07 Smith-Waterman score: 228; 27.3% identity (56.4% similar) in 172 aa overlap (7-178:46-196) 10 20 30 pF1KB6 MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFR :: .. :. :.::.. ::. . XP_016 MKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSP---- 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB6 SYVFYHHQQEQEAEGAAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTM : : :::: : . .: :. :. :::..::: .: : XP_016 -------LQTPAAPGAAA--GPALSPVPPVVHLTLRQA-------GDDFSRRYRRDFAEM 80 90 100 110 100 110 120 130 140 150 pF1KB6 LQHLQPTAENAYEYFTKIASSLFESGINWGRVVALLGFSYRLALHIYQRGLTGFLGQVTR ..:. : .: :. .. ::..:.::::.::.. :. . .. .: .. .. ... XP_016 SSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIAL 120 130 140 150 160 170 160 170 180 190 200 210 pF1KB6 FVVDFMLHHCIARWIAQRGGWVAALNLGNGPILNVLVVLGVVLLGQFVVRRFFKS ...... .: . :: . :::. XP_016 WMTEYLNRH-LHTWIQDNGGWLYM 180 190 >>XP_011524437 (OMIM: 151430) PREDICTED: apoptosis regul (224 aa) initn: 251 init1: 152 opt: 217 Z-score: 257.1 bits: 54.7 E(85289): 1.4e-07 Smith-Waterman score: 228; 27.7% identity (56.1% similar) in 173 aa overlap (7-179:46-197) 10 20 30 pF1KB6 MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFR :: .. :. :.::.. ::. . XP_011 MKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSP---- 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB6 SYVFYHHQQEQEAEGAAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTM : : :::: : . .: :. :. :::..::: .: : XP_011 -------LQTPAAPGAAA--GPALSPVPPVVHLTLRQA-------GDDFSRRYRRDFAEM 80 90 100 110 100 110 120 130 140 150 pF1KB6 LQHLQPTAENAYEYFTKIASSLFESGINWGRVVALLGFSYRLALHIYQRGLTGFLGQVTR ..:. : .: :. .. ::..:.::::.::.. :. . .. .: .. .. ... XP_011 SSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIAL 120 130 140 150 160 170 160 170 180 190 200 210 pF1KB6 FVVDFMLHHCIARWIAQRGGWVAALNLGNGPILNVLVVLGVVLLGQFVVRRFFKS ...... .: . :: . ::: : XP_011 WMTEYLNRH-LHTWIQDNGGWDALVLFAGLREFQHGPGNYFLKRNLNAKF 180 190 200 210 220 >>NP_620116 (OMIM: 600040) apoptosis regulator BAX isofo (192 aa) initn: 160 init1: 87 opt: 209 Z-score: 248.8 bits: 52.9 E(85289): 4e-07 Smith-Waterman score: 209; 23.2% identity (63.3% similar) in 177 aa overlap (31-205:16-187) 10 20 30 40 50 60 pF1KB6 MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYHHQQEQEAEGAAAPADPEM .:..... .. . :. : . ::. NP_620 MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPEL 10 20 30 40 70 80 90 100 110 120 pF1KB6 VTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIASSLFE . :. ... .... : :::... . :.: :. .. ... : : ..:...: NP_620 ALDPVPQDASTKKLSECLKRIGDELDS--NMELQRMIAAVD--TDSPREVFFRVAADMFS 50 60 70 80 90 100 130 140 150 160 170 pF1KB6 SG-INWGRVVALLGFSYRLALHIYQRGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVA .: .::::::::. :. .:.:. . .. . ...::. .. .. :: ..::: . NP_620 DGNFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLG-WIQDQGGWDG 110 120 130 140 150 160 180 190 200 210 pF1KB6 ALN-LGNGPILNVLVVLGVVLLGQFVVRRFFKS :. .:. .: . .. :: ..... NP_620 LLSYFGTPTWQTVTIFVAGVLTASLTIWKKMG 170 180 190 >>NP_001309169 (OMIM: 600039) bcl-2-like protein 1 isofo (233 aa) initn: 231 init1: 164 opt: 210 Z-score: 248.8 bits: 53.2 E(85289): 4.1e-07 Smith-Waterman score: 222; 27.6% identity (62.5% similar) in 152 aa overlap (71-207:83-233) 50 60 70 80 90 100 pF1KB6 YHHQQEQEAEGAAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHL :. : . : ::... :: :. . ..: NP_001 GNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQL 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB6 QPTAENAYEYFTKIASSLFESGINWGRVVALLGFSYRLALHIYQRGLTGFLGQVTRFVVD . : .::. : .... ::..:.::::.::...:. : .. .. . ...... ... NP_001 HITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMAT 120 130 140 150 160 170 170 180 190 200 pF1KB6 FMLHHCIARWIAQRGGWVAALNL-GNGP--------------ILNVLVVLGVVLLGQFVV .. : . :: . ::: . ..: ::. .:. ..: ::::::.. NP_001 YLNDH-LEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFS 180 190 200 210 220 230 210 pF1KB6 RRFFKS :. NP_001 RK >>NP_001304848 (OMIM: 600039) bcl-2-like protein 1 isofo (233 aa) initn: 231 init1: 164 opt: 210 Z-score: 248.8 bits: 53.2 E(85289): 4.1e-07 Smith-Waterman score: 222; 27.6% identity (62.5% similar) in 152 aa overlap (71-207:83-233) 50 60 70 80 90 100 pF1KB6 YHHQQEQEAEGAAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHL :. : . : ::... :: :. . ..: NP_001 GNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQL 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB6 QPTAENAYEYFTKIASSLFESGINWGRVVALLGFSYRLALHIYQRGLTGFLGQVTRFVVD . : .::. : .... ::..:.::::.::...:. : .. .. . ...... ... NP_001 HITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMAT 120 130 140 150 160 170 170 180 190 200 pF1KB6 FMLHHCIARWIAQRGGWVAALNL-GNGP--------------ILNVLVVLGVVLLGQFVV .. : . :: . ::: . ..: ::. .:. ..: ::::::.. NP_001 YLNDH-LEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFS 180 190 200 210 220 230 210 pF1KB6 RRFFKS :. NP_001 RK 211 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 02:18:13 2016 done: Sat Nov 5 02:18:14 2016 Total Scan time: 6.570 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]