Result of FASTA (omim) for
pF1KB7004
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7004, 1340 aa
1>>>pF1KB7004 1340 - 1340 aa - 1340 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 16.0698+/-0.000478; mu= -25.7671+/- 0.030
mean_var=771.9995+/-161.681, 0's: 0 Z-trim(124.4): 288 B-trim: 0 in 0/61
Lambda= 0.046160
statistics sampled from 45686 (46001) to 45686 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.789), E-opt: 0.2 (0.539), width: 16
Scan time: 20.740
The best scores are: opt bits E(85289)
XP_005277474 (OMIM: 602597) PREDICTED: B-cell CLL/ (1414) 9192 628.7 9.1e-179
XP_016857515 (OMIM: 602597) PREDICTED: B-cell CLL/ (1352) 7085 488.3 1.5e-136
XP_005277475 (OMIM: 602597) PREDICTED: B-cell CLL/ (1352) 7085 488.3 1.5e-136
XP_005273028 (OMIM: 602597) PREDICTED: B-cell CLL/ (1426) 6774 467.6 2.7e-130
NP_004317 (OMIM: 602597) B-cell CLL/lymphoma 9 pro (1426) 6774 467.6 2.7e-130
XP_005271570 (OMIM: 609004) PREDICTED: B-cell CLL/ (1462) 1263 100.7 8.4e-20
XP_005271569 (OMIM: 609004) PREDICTED: B-cell CLL/ (1462) 1263 100.7 8.4e-20
XP_006718878 (OMIM: 609004) PREDICTED: B-cell CLL/ (1499) 1263 100.7 8.5e-20
XP_005271568 (OMIM: 609004) PREDICTED: B-cell CLL/ (1499) 1263 100.7 8.5e-20
NP_872363 (OMIM: 609004) B-cell CLL/lymphoma 9-lik (1499) 1263 100.7 8.5e-20
XP_016873063 (OMIM: 609004) PREDICTED: B-cell CLL/ (1513) 1263 100.7 8.6e-20
XP_011541058 (OMIM: 609004) PREDICTED: B-cell CLL/ (1514) 1263 100.7 8.6e-20
XP_016873062 (OMIM: 609004) PREDICTED: B-cell CLL/ (1544) 1263 100.7 8.7e-20
XP_016873061 (OMIM: 609004) PREDICTED: B-cell CLL/ (1547) 1263 100.7 8.8e-20
NP_000486 (OMIM: 301050,303630) collagen alpha-5(I (1685) 782 68.7 4.1e-10
XP_016884749 (OMIM: 301050,303630) PREDICTED: coll (1690) 782 68.7 4.1e-10
XP_016884748 (OMIM: 301050,303630) PREDICTED: coll (1693) 661 60.6 1.1e-07
XP_016858786 (OMIM: 120131,203780) PREDICTED: coll (1651) 612 57.3 1e-06
NP_203699 (OMIM: 301050,303630) collagen alpha-5(I (1691) 602 56.7 1.7e-06
XP_011529151 (OMIM: 301050,303630) PREDICTED: coll (1696) 602 56.7 1.7e-06
XP_011508859 (OMIM: 120131,203780) PREDICTED: coll (1663) 576 54.9 5.5e-06
XP_016869755 (OMIM: 120215,130000) PREDICTED: coll (1715) 576 55.0 5.6e-06
NP_001265003 (OMIM: 120215,130000) collagen alpha- (1838) 576 55.0 5.9e-06
NP_000084 (OMIM: 120215,130000) collagen alpha-1(V (1838) 576 55.0 5.9e-06
XP_016884752 (OMIM: 301050,303630) PREDICTED: coll (1136) 545 52.7 1.7e-05
XP_005246339 (OMIM: 120131,203780) PREDICTED: coll (1505) 537 52.3 3.1e-05
NP_542197 (OMIM: 120280,154780,228520,603932,60484 (1690) 535 52.2 3.7e-05
XP_016858789 (OMIM: 120131,203780) PREDICTED: coll (1414) 532 52.0 3.7e-05
XP_011508872 (OMIM: 120131,203780) PREDICTED: coll (1414) 532 52.0 3.7e-05
XP_011508871 (OMIM: 120131,203780) PREDICTED: coll (1414) 532 52.0 3.7e-05
XP_011508870 (OMIM: 120131,203780) PREDICTED: coll (1419) 532 52.0 3.7e-05
XP_011508869 (OMIM: 120131,203780) PREDICTED: coll (1420) 532 52.0 3.7e-05
XP_011508868 (OMIM: 120131,203780) PREDICTED: coll (1420) 532 52.0 3.7e-05
XP_011508867 (OMIM: 120131,203780) PREDICTED: coll (1424) 532 52.0 3.7e-05
XP_016858788 (OMIM: 120131,203780) PREDICTED: coll (1518) 532 52.0 3.9e-05
XP_011508864 (OMIM: 120131,203780) PREDICTED: coll (1608) 532 52.0 4.1e-05
XP_016858787 (OMIM: 120131,203780) PREDICTED: coll (1608) 532 52.0 4.1e-05
XP_011508863 (OMIM: 120131,203780) PREDICTED: coll (1608) 532 52.0 4.1e-05
XP_011508861 (OMIM: 120131,203780) PREDICTED: coll (1612) 532 52.0 4.1e-05
XP_011508862 (OMIM: 120131,203780) PREDICTED: coll (1612) 532 52.0 4.1e-05
XP_006712309 (OMIM: 120131,203780) PREDICTED: coll (1627) 532 52.0 4.1e-05
XP_016858785 (OMIM: 120131,203780) PREDICTED: coll (1659) 532 52.0 4.2e-05
XP_005246338 (OMIM: 120131,203780) PREDICTED: coll (1690) 532 52.0 4.2e-05
NP_000083 (OMIM: 120131,203780) collagen alpha-4(I (1690) 532 52.0 4.2e-05
XP_011508860 (OMIM: 120131,203780) PREDICTED: coll (1654) 509 50.5 0.00012
XP_005246334 (OMIM: 104200,120070,141200,203780) P (1635) 503 50.1 0.00016
XP_016855825 (OMIM: 120280,154780,228520,603932,60 (1515) 501 49.9 0.00016
NP_001177638 (OMIM: 120280,154780,228520,603932,60 (1767) 501 50.0 0.00018
NP_001845 (OMIM: 120280,154780,228520,603932,60484 (1806) 501 50.0 0.00019
NP_542196 (OMIM: 120280,154780,228520,603932,60484 (1818) 501 50.0 0.00019
>>XP_005277474 (OMIM: 602597) PREDICTED: B-cell CLL/lymp (1414 aa)
initn: 9177 init1: 9177 opt: 9192 Z-score: 3330.4 bits: 628.7 E(85289): 9.1e-179
Smith-Waterman score: 9192; 96.8% identity (98.0% similar) in 1344 aa overlap (6-1340:73-1414)
10 20
pF1KB7 MHSSNPKVRSSPSGN--------TQSSPKSKQEVM
::. .:.:. . .. :.:.:
XP_005 DSKFSNQGKQGGSASQSQPSPCDSKSGGHTPKALPGPGGSMGLKNGAGNGAKGKGKRERS
50 60 70 80 90 100
30 40 50 60 70 80
pF1KB7 VRPPTV-MSPSGNPQLDSKFSNQECNSADHIKSQDSQHTPHSMTPSNATAPRSSTPSHGQ
. . . :.:. :: . .:::::::::::::::::::::::::::::::::::::
XP_005 ISADSFDQRDPGTPNDDSDI--KECNSADHIKSQDSQHTPHSMTPSNATAPRSSTPSHGQ
110 120 130 140 150 160
90 100 110 120 130 140
pF1KB7 TTATEPTPAQKTPAKVVYVFSTEMANKAAEAVLKGQVETIVSFHIQNISNNKTERSTAPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TTATEPTPAQKTPAKVVYVFSTEMANKAAEAVLKGQVETIVSFHIQNISNNKTERSTAPL
170 180 190 200 210 220
150 160 170 180 190 200
pF1KB7 NTQISALRNDPKPLPQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRESPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NTQISALRNDPKPLPQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRESPG
230 240 250 260 270 280
210 220 230 240 250 260
pF1KB7 VENKLIPSVGSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VENKLIPSVGSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGE
290 300 310 320 330 340
270 280 290 300 310 320
pF1KB7 PPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQK
350 360 370 380 390 400
330 340 350 360 370 380
pF1KB7 KPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPD
410 420 430 440 450 460
390 400 410 420 430 440
pF1KB7 HLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQM
470 480 490 500 510 520
450 460 470 480 490 500
pF1KB7 TPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPN
530 540 550 560 570 580
510 520 530 540 550 560
pF1KB7 PASRPGLSGVSWPDDVPKIPDGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PASRPGLSGVSWPDDVPKIPDGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQ
590 600 610 620 630 640
570 580 590 600 610 620
pF1KB7 LGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQ
650 660 670 680 690 700
630 640 650 660 670 680
pF1KB7 MGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPGGSDMLPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPGGSDMLPA
710 720 730 740 750 760
690 700 710 720 730 740
pF1KB7 QQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPL
770 780 790 800 810 820
750 760 770 780 790 800
pF1KB7 PLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPS
830 840 850 860 870 880
810 820 830 840 850 860
pF1KB7 GNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPP
890 900 910 920 930 940
870 880 890 900 910 920
pF1KB7 LQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQPASVNIPGSLPSSTPYTMPPEPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQPASVNIPGSLPSSTPYTMPPEPT
950 960 970 980 990 1000
930 940 950 960 970 980
pF1KB7 LSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGPNPVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGPNPVV
1010 1020 1030 1040 1050 1060
990 1000 1010 1020 1030 1040
pF1KB7 PMPTLSPMGMTQPLSHSNQMPSPNAVGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PMPTLSPMGMTQPLSHSNQMPSPNAVGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQ
1070 1080 1090 1100 1110 1120
1050 1060 1070 1080 1090 1100
pF1KB7 GRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPGEGPLGRPSNLPQSSADAAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPGEGPLGRPSNLPQSSADAAL
1130 1140 1150 1160 1170 1180
1110 1120 1130 1140 1150 1160
pF1KB7 CKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQMLQYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::
XP_005 CKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYF
1190 1200 1210 1220 1230 1240
1170 1180 1190 1200 1210 1220
pF1KB7 PRGEVPGRKQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSMPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRGEVPGRKQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSMPG
1250 1260 1270 1280 1290 1300
1230 1240 1250 1260 1270 1280
pF1KB7 HNPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HNPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHP
1310 1320 1330 1340 1350 1360
1290 1300 1310 1320 1330 1340
pF1KB7 GPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPGNMMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGNPGNMMF
1370 1380 1390 1400 1410
>>XP_016857515 (OMIM: 602597) PREDICTED: B-cell CLL/lymp (1352 aa)
initn: 6989 init1: 6869 opt: 7085 Z-score: 2572.3 bits: 488.3 E(85289): 1.5e-136
Smith-Waterman score: 9469; 99.0% identity (99.0% similar) in 1352 aa overlap (1-1340:1-1352)
10 20 30 40 50 60
pF1KB7 MHSSNPKVRSSPSGNTQSSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQECNSADHIKSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MHSSNPKVRSSPSGNTQSSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQECNSADHIKSQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 DSQHTPHSMTPSNATAPRSSTPSHGQTTATEPTPAQKTPAKVVYVFSTEMANKAAEAVLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSQHTPHSMTPSNATAPRSSTPSHGQTTATEPTPAQKTPAKVVYVFSTEMANKAAEAVLK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 GQVETIVSFHIQNISNNKTERSTAPLNTQISALRNDPKPLPQQPPAPANQDQNSSQNTRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQVETIVSFHIQNISNNKTERSTAPLNTQISALRNDPKPLPQQPPAPANQDQNSSQNTRL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 QPTPPIPAPAPKPAAPPRPLDRESPGVENKLIPSVGSPASSTPLPPDGTGPNSTPNNRAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPTPPIPAPAPKPAAPPRPLDRESPGVENKLIPSVGSPASSTPLPPDGTGPNSTPNNRAV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 TPVSQGSNSSSADPKAPPPPPVSSGEPPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPVSQGSNSSSADPKAPPPPPVSSGEPPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 PDEKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDEKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 HRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB7 CSLQDMMVHQHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CSLQDMMVHQHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPN
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB7 MPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGIFSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGIFSG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB7 PGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNN
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB7 PIFPRIPVEGPLSPSRGDFPKGIPPQMGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PIFPRIPVEGPLSPSRGDFPKGIPPQMGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMIP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB7 QKMREAGAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKMREAGAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSN
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB7 SGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB7 VHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB7 AASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPT
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB7 ASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVAS
910 920 930 940 950 960
970 980 990 1000
pF1KB7 SDDDSPPARSPNLPSMNNMPG------------PNPVVPMPTLSPMGMTQPLSHSNQMPS
::::::::::::::::::::: :::::::::::::::::::::::::::
XP_016 SDDDSPPARSPNLPSMNNMPGMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPS
970 980 990 1000 1010 1020
1010 1020 1030 1040 1050 1060
pF1KB7 PNAVGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PNAVGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFP
1030 1040 1050 1060 1070 1080
1070 1080 1090 1100 1110 1120
pF1KB7 HNGPSGGQGSFPGGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HNGPSGGQGSFPGGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSV
1090 1100 1110 1120 1130 1140
1130 1140 1150 1160 1170 1180
pF1KB7 FTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQMLQYFPRGEVPGRKQPQGPGPGFSHMQ
::::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::
XP_016 FTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQ
1150 1160 1170 1180 1190 1200
1190 1200 1210 1220 1230 1240
pF1KB7 GMMGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GMMGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMM
1210 1220 1230 1240 1250 1260
1250 1260 1270 1280 1290 1300
pF1KB7 SPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNI
1270 1280 1290 1300 1310 1320
1310 1320 1330 1340
pF1KB7 MIPPQMRPRGMAADVGMGGFSQGPGNPGNMMF
::::::::::::::::::::::::::::::::
XP_016 MIPPQMRPRGMAADVGMGGFSQGPGNPGNMMF
1330 1340 1350
>>XP_005277475 (OMIM: 602597) PREDICTED: B-cell CLL/lymp (1352 aa)
initn: 6989 init1: 6869 opt: 7085 Z-score: 2572.3 bits: 488.3 E(85289): 1.5e-136
Smith-Waterman score: 9469; 99.0% identity (99.0% similar) in 1352 aa overlap (1-1340:1-1352)
10 20 30 40 50 60
pF1KB7 MHSSNPKVRSSPSGNTQSSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQECNSADHIKSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MHSSNPKVRSSPSGNTQSSPKSKQEVMVRPPTVMSPSGNPQLDSKFSNQECNSADHIKSQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 DSQHTPHSMTPSNATAPRSSTPSHGQTTATEPTPAQKTPAKVVYVFSTEMANKAAEAVLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DSQHTPHSMTPSNATAPRSSTPSHGQTTATEPTPAQKTPAKVVYVFSTEMANKAAEAVLK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 GQVETIVSFHIQNISNNKTERSTAPLNTQISALRNDPKPLPQQPPAPANQDQNSSQNTRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GQVETIVSFHIQNISNNKTERSTAPLNTQISALRNDPKPLPQQPPAPANQDQNSSQNTRL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 QPTPPIPAPAPKPAAPPRPLDRESPGVENKLIPSVGSPASSTPLPPDGTGPNSTPNNRAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QPTPPIPAPAPKPAAPPRPLDRESPGVENKLIPSVGSPASSTPLPPDGTGPNSTPNNRAV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 TPVSQGSNSSSADPKAPPPPPVSSGEPPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TPVSQGSNSSSADPKAPPPPPVSSGEPPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 PDEKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PDEKEFTGAQSGGPQQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 HRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB7 CSLQDMMVHQHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CSLQDMMVHQHGPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPN
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB7 MPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGIFSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MPGSQMRLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDGRNFPPGQGIFSG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB7 PGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PGRGERFPNPQGLSEEMFQQQLAEKQLGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNN
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB7 PIFPRIPVEGPLSPSRGDFPKGIPPQMGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PIFPRIPVEGPLSPSRGDFPKGIPPQMGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMIP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB7 QKMREAGAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QKMREAGAGPEEMLKLRPGGSDMLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSN
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB7 SGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGLRNLREPIGPDQRTNSRLSHMPPLPLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQ
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB7 VHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VHSPGINPLKSPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB7 AASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPT
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB7 ASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVAS
910 920 930 940 950 960
970 980 990 1000
pF1KB7 SDDDSPPARSPNLPSMNNMPG------------PNPVVPMPTLSPMGMTQPLSHSNQMPS
::::::::::::::::::::: :::::::::::::::::::::::::::
XP_005 SDDDSPPARSPNLPSMNNMPGMGINTQNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPS
970 980 990 1000 1010 1020
1010 1020 1030 1040 1050 1060
pF1KB7 PNAVGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PNAVGPNIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFP
1030 1040 1050 1060 1070 1080
1070 1080 1090 1100 1110 1120
pF1KB7 HNGPSGGQGSFPGGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HNGPSGGQGSFPGGMGFPGEGPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSV
1090 1100 1110 1120 1130 1140
1130 1140 1150 1160 1170 1180
pF1KB7 FTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQMLQYFPRGEVPGRKQPQGPGPGFSHMQ
::::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::
XP_005 FTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQ
1150 1160 1170 1180 1190 1200
1190 1200 1210 1220 1230 1240
pF1KB7 GMMGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GMMGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMM
1210 1220 1230 1240 1250 1260
1250 1260 1270 1280 1290 1300
pF1KB7 SPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNI
1270 1280 1290 1300 1310 1320
1310 1320 1330 1340
pF1KB7 MIPPQMRPRGMAADVGMGGFSQGPGNPGNMMF
::::::::::::::::::::::::::::::::
XP_005 MIPPQMRPRGMAADVGMGGFSQGPGNPGNMMF
1330 1340 1350
>>XP_005273028 (OMIM: 602597) PREDICTED: B-cell CLL/lymp (1426 aa)
initn: 6631 init1: 6543 opt: 6774 Z-score: 2460.1 bits: 467.6 E(85289): 2.7e-130
Smith-Waterman score: 9158; 95.9% identity (97.1% similar) in 1356 aa overlap (6-1340:73-1426)
10 20
pF1KB7 MHSSNPKVRSSPSGN--------TQSSPKSKQEVM
::. .:.:. . .. :.:.:
XP_005 DSKFSNQGKQGGSASQSQPSPCDSKSGGHTPKALPGPGGSMGLKNGAGNGAKGKGKRERS
50 60 70 80 90 100
30 40 50 60 70 80
pF1KB7 VRPPTV-MSPSGNPQLDSKFSNQECNSADHIKSQDSQHTPHSMTPSNATAPRSSTPSHGQ
. . . :.:. :: . .:::::::::::::::::::::::::::::::::::::
XP_005 ISADSFDQRDPGTPNDDSDI--KECNSADHIKSQDSQHTPHSMTPSNATAPRSSTPSHGQ
110 120 130 140 150 160
90 100 110 120 130 140
pF1KB7 TTATEPTPAQKTPAKVVYVFSTEMANKAAEAVLKGQVETIVSFHIQNISNNKTERSTAPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TTATEPTPAQKTPAKVVYVFSTEMANKAAEAVLKGQVETIVSFHIQNISNNKTERSTAPL
170 180 190 200 210 220
150 160 170 180 190 200
pF1KB7 NTQISALRNDPKPLPQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRESPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NTQISALRNDPKPLPQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRESPG
230 240 250 260 270 280
210 220 230 240 250 260
pF1KB7 VENKLIPSVGSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VENKLIPSVGSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGE
290 300 310 320 330 340
270 280 290 300 310 320
pF1KB7 PPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQK
350 360 370 380 390 400
330 340 350 360 370 380
pF1KB7 KPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPD
410 420 430 440 450 460
390 400 410 420 430 440
pF1KB7 HLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQM
470 480 490 500 510 520
450 460 470 480 490 500
pF1KB7 TPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPN
530 540 550 560 570 580
510 520 530 540 550 560
pF1KB7 PASRPGLSGVSWPDDVPKIPDGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PASRPGLSGVSWPDDVPKIPDGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQ
590 600 610 620 630 640
570 580 590 600 610 620
pF1KB7 LGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQ
650 660 670 680 690 700
630 640 650 660 670 680
pF1KB7 MGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPGGSDMLPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPGGSDMLPA
710 720 730 740 750 760
690 700 710 720 730 740
pF1KB7 QQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPL
770 780 790 800 810 820
750 760 770 780 790 800
pF1KB7 PLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPS
830 840 850 860 870 880
810 820 830 840 850 860
pF1KB7 GNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPP
890 900 910 920 930 940
870 880 890 900 910 920
pF1KB7 LQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQPASVNIPGSLPSSTPYTMPPEPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQPASVNIPGSLPSSTPYTMPPEPT
950 960 970 980 990 1000
930 940 950 960 970 980
pF1KB7 LSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPG-----
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINT
1010 1020 1030 1040 1050 1060
990 1000 1010 1020 1030
pF1KB7 -------PNPVVPMPTLSPMGMTQPLSHSNQMPSPNAVGPNIPPHGVPMGPGLMSHNPIM
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAVGPNIPPHGVPMGPGLMSHNPIM
1070 1080 1090 1100 1110 1120
1040 1050 1060 1070 1080 1090
pF1KB7 GHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPGEGPLGRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPGEGPLGRP
1130 1140 1150 1160 1170 1180
1100 1110 1120 1130 1140 1150
pF1KB7 SNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRII
1190 1200 1210 1220 1230 1240
1160 1170 1180 1190 1200 1210
pF1KB7 PSEKPSQMLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGPGPVGTP
::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGPGPVGTP
1250 1260 1270 1280 1290 1300
1220 1230 1240 1250 1260 1270
pF1KB7 DIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPG
1310 1320 1330 1340 1350 1360
1280 1290 1300 1310 1320 1330
pF1KB7 KDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGN
1370 1380 1390 1400 1410 1420
1340
pF1KB7 PGNMMF
::::::
XP_005 PGNMMF
>>NP_004317 (OMIM: 602597) B-cell CLL/lymphoma 9 protein (1426 aa)
initn: 6631 init1: 6543 opt: 6774 Z-score: 2460.1 bits: 467.6 E(85289): 2.7e-130
Smith-Waterman score: 9158; 95.9% identity (97.1% similar) in 1356 aa overlap (6-1340:73-1426)
10 20
pF1KB7 MHSSNPKVRSSPSGN--------TQSSPKSKQEVM
::. .:.:. . .. :.:.:
NP_004 DSKFSNQGKQGGSASQSQPSPCDSKSGGHTPKALPGPGGSMGLKNGAGNGAKGKGKRERS
50 60 70 80 90 100
30 40 50 60 70 80
pF1KB7 VRPPTV-MSPSGNPQLDSKFSNQECNSADHIKSQDSQHTPHSMTPSNATAPRSSTPSHGQ
. . . :.:. :: . .:::::::::::::::::::::::::::::::::::::
NP_004 ISADSFDQRDPGTPNDDSDI--KECNSADHIKSQDSQHTPHSMTPSNATAPRSSTPSHGQ
110 120 130 140 150 160
90 100 110 120 130 140
pF1KB7 TTATEPTPAQKTPAKVVYVFSTEMANKAAEAVLKGQVETIVSFHIQNISNNKTERSTAPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TTATEPTPAQKTPAKVVYVFSTEMANKAAEAVLKGQVETIVSFHIQNISNNKTERSTAPL
170 180 190 200 210 220
150 160 170 180 190 200
pF1KB7 NTQISALRNDPKPLPQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRESPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NTQISALRNDPKPLPQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKPAAPPRPLDRESPG
230 240 250 260 270 280
210 220 230 240 250 260
pF1KB7 VENKLIPSVGSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VENKLIPSVGSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSADPKAPPPPPVSSGE
290 300 310 320 330 340
270 280 290 300 310 320
pF1KB7 PPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PPTLGENPDGLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSGGPQQNPGVLDGPQK
350 360 370 380 390 400
330 340 350 360 370 380
pF1KB7 KPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KPEGPIQAMMAQSQSLGKGPGPRTDVGAPFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPD
410 420 430 440 450 460
390 400 410 420 430 440
pF1KB7 HLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 HLDHMTPEQIAWLKLQQEFYEEKRRKQEQVVVQQCSLQDMMVHQHGPRGVVRGPPPPYQM
470 480 490 500 510 520
450 460 470 480 490 500
pF1KB7 TPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGSQMRLPGFAGMINSEMEGPNVPN
530 540 550 560 570 580
510 520 530 540 550 560
pF1KB7 PASRPGLSGVSWPDDVPKIPDGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PASRPGLSGVSWPDDVPKIPDGRNFPPGQGIFSGPGRGERFPNPQGLSEEMFQQQLAEKQ
590 600 610 620 630 640
570 580 590 600 610 620
pF1KB7 LGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LGLPPGMAMEGIRPSMEMNRMIPGSQRHMEPGNNPIFPRIPVEGPLSPSRGDFPKGIPPQ
650 660 670 680 690 700
630 640 650 660 670 680
pF1KB7 MGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPGGSDMLPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMIPQKMREAGAGPEEMLKLRPGGSDMLPA
710 720 730 740 750 760
690 700 710 720 730 740
pF1KB7 QQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRTNSRLSHMPPL
770 780 790 800 810 820
750 760 770 780 790 800
pF1KB7 PLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PLNPSSNPTSLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLKSPTMHQVQSPMLGSPS
830 840 850 860 870 880
810 820 830 840 850 860
pF1KB7 GNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPP
890 900 910 920 930 940
870 880 890 900 910 920
pF1KB7 LQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQPASVNIPGSLPSSTPYTMPPEPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LQSPGIPPNHKAPLTMASPAMLGNVESGGPPPPTASQPASVNIPGSLPSSTPYTMPPEPT
950 960 970 980 990 1000
930 940 950 960 970 980
pF1KB7 LSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPG-----
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINT
1010 1020 1030 1040 1050 1060
990 1000 1010 1020 1030
pF1KB7 -------PNPVVPMPTLSPMGMTQPLSHSNQMPSPNAVGPNIPPHGVPMGPGLMSHNPIM
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QNPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAVGPNIPPHGVPMGPGLMSHNPIM
1070 1080 1090 1100 1110 1120
1040 1050 1060 1070 1080 1090
pF1KB7 GHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPGEGPLGRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPGEGPLGRP
1130 1140 1150 1160 1170 1180
1100 1110 1120 1130 1140 1150
pF1KB7 SNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SNLPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRII
1190 1200 1210 1220 1230 1240
1160 1170 1180 1190 1200 1210
pF1KB7 PSEKPSQMLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGPGPVGTP
::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGPGPVGTP
1250 1260 1270 1280 1290 1300
1220 1230 1240 1250 1260 1270
pF1KB7 DIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPG
1310 1320 1330 1340 1350 1360
1280 1290 1300 1310 1320 1330
pF1KB7 KDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KDRGPAGLYTHPGPVGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVGMGGFSQGPGN
1370 1380 1390 1400 1410 1420
1340
pF1KB7 PGNMMF
::::::
NP_004 PGNMMF
>>XP_005271570 (OMIM: 609004) PREDICTED: B-cell CLL/lymp (1462 aa)
initn: 980 init1: 262 opt: 1263 Z-score: 476.5 bits: 100.7 E(85289): 8.4e-20
Smith-Waterman score: 2523; 37.8% identity (59.1% similar) in 1462 aa overlap (3-1333:84-1455)
10 20
pF1KB7 MHSSNPKVRSSPSGNTQS---SPKSKQE-VMV
:.. . ..:: .... .:.::.. :.
XP_005 NSSLKNPQAGVPPFSSLKGKVKRDRSVSVDSGEQREAGTPSLDSEAKEVAPRSKRRCVLE
60 70 80 90 100 110
30 40 50 60 70 80
pF1KB7 RPPTVMSPSGNPQLDSKFSNQECNSADHIKSQDSQHTPHSMTPSNATA-P--RSSTPS--
: . ::. ... ... . . : . .. :...: : .::.:.
XP_005 RKQPYSGDEWCSGPDSEEDDKPIGATHNCNVADPAMAAPQLGPGQTTQLPLSESSVPGAP
120 130 140 150 160 170
90 100 110 120 130
pF1KB7 HGQTTATEP-TPAQ---------KTPAKVVYVFSTEMANKAAEAVLKGQVETIVSFHIQN
:: . .: .:. : :.. ::::.:..:: ::::::.:....:...: ::
XP_005 HGPPPGLRPDAPGGGGGGGGVPGKPPSQFVYVFTTHLANTAAEAVLQGRADSILAYHQQN
180 190 200 210 220 230
140 150 160 170 180 190
pF1KB7 ISNNKTERSTAPLNTQISALRNDPKPLPQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKP
. : .. :: . :.::: . :. :. : :: : :: : :::
XP_005 VPRAKLDQ--AP------KVPPTPEPLPLSTPS-AGTPQ--SQPP---PLPPPPPPAPGS
240 250 260 270
200 210 220 230 240 250
pF1KB7 AAPPRPLDRESPGVENKLIP-SVGSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSA
: : : . . : : ::: :.:: :: ::. . : .:. :.. :::
XP_005 APPALPPEGPPEDSSQDLAPNSVG--AASTGGGTGGTHPNTPTATTANNPLPPGGDPSSA
280 290 300 310 320 330
260 270 280 290 300
pF1KB7 DPKAPPPPPVSSGEPPTLGE----NPDGLSQEQLEHRERSLQTLRDIQRMLF-PDEKE-F
: : .. . : :. . .:::.::::::::::::::::.:.:. : : :
XP_005 ----PGPALLGEAAAPGNGQRSLVGSEGLSKEQLEHRERSLQTLRDIERLLLRSGETEPF
340 350 360 370 380 390
310 320 330 340 350
pF1KB7 T-----GAQSGGP--------QQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGPGPRTDVG
:: ::: :: : . . :: : :.:.:..:.:::: :: .
XP_005 LKGPPGGAGEGGPPAQAPPPPQQPPTAPPSGLKKYEEPLQSMISQTQSLG---GPPLEHE
400 410 420 430 440 450
360 370 380 390 400 410
pF1KB7 APFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQ
.: :: : . : . .:: . .: : : ::::.:: :::.:.:::::::.
XP_005 VP----GH---PPGGD--MGQQMNMMIQRLGQDSL---TPEQVAWRKLQEEYYEEKRRKE
460 470 480 490
420 430 440 450 460 470
pF1KB7 EQVVVQQCS-LQDMMVHQHGPRGV-VRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLP
::. .. ::::: : :. ::::::::. :.. : :: . ... .
XP_005 EQIGLHGSRPLQDMM----GMGGMMVRGPPPPYHSKPGDQWPPGMGAQLRGPMDVQDPMQ
500 510 520 530 540 550
480 490 500 510 520
pF1KB7 PRGMAPHPN--MPGSQM-RLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDG
:: : :. .::.:. :.:::.:: . :: : : .:: :..: .:.: .
XP_005 LRGGPPFPGPRFPGNQIQRVPGFGGMQSMPMEVPM--NAMQRPVRPGMGWTEDLPPMGGP
560 570 580 590 600 610
530 540 550 560 570 580
pF1KB7 RNFPPGQGIF-SGPGRGERFPNPQGLSEEMFQQQLAEKQ-LGL--PPGMAMEGIRPSMEM
:: . . .: :..::: .:. . ::....:: ::. .:. : ::: :. ::::
XP_005 SNFAQNTMPYPGGQGEAERFMTPR-VREELLRHQLLEKRSMGMQRPLGMAGSGMGQSMEM
620 630 640 650 660 670
590 600 610 620 630
pF1KB7 NRMIPGSQRHMEPGNNPIFPRIPVEGPL---SPSRGDFPKG---IPPQMGPG--RELEFG
.::. ..:.:.:. .:: . : .: .: : . : :: . ::..
XP_005 ERMMQ-AHRQMDPA---MFPGQMAGGEGLAGTPMGMEFGGGRGLLSPPMGQSGLREVDPP
680 690 700 710 720
640 650 660 670
pF1KB7 MVPSG--MKGDVNLNVNMGSNSQMIPQ-------KMR-------EAGAGPEEMLKLRP-G
: :.. :. .::.:.::. : :: :: ::: : .:::: ..: .
XP_005 MGPGNLNMNMNVNMNMNMNLNVQMTPQQQMLMSQKMRGPGDLMGPQGLSPEEMARVRAQN
730 740 750 760 770 780
680 690 700 710 720 730
pF1KB7 GSDMLPAQQKMV-PLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRT--
.: .. . :::. : : .. :: .. : :. ::: : : .. ..::: .
XP_005 SSGVMGGPQKMLMPSQFPNQGQQGFSGGQGPYQAMSQDMG------NTQDMFSPDQSSMP
790 800 810 820 830 840
740 750 760 770 780 790
pF1KB7 -----NSRLSHMPPLPLNPSSNPT-SLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLK
..:::::: :: :.::: ....:: .:::::.: :.... .:. :::.. ::
XP_005 MSNVGTTRLSHMP-LP--PASNPPGTVHSAP--NRGLGRRPSDLTISINQMGSPGMGHLK
850 860 870 880 890
800 810 820 830 840
pF1KB7 SPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSA------AASP
:::. ::.::.. :::.::::::::::.. : . . .::: ::::. ..::
XP_005 SPTLSQVHSPLVTSPSANLKSPQTPSQMVP-LPSANPPGPLKSPQVLGSSLSVRSPTGSP
900 910 920 930 940 950
850 860 870 880 890 900
pF1KB7 VHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPP--PTAS
.:::::. .:::::..::: . :::. :.. ::.: : . :.:.:.: :: : .:
XP_005 SRLKSPSMAVPSPGWVASPKTAMPSPGVSQNKQPPLNMNSSTTLSNMEQGTLPPSGPRSS
960 970 980 990 1000 1010
910 920 930 940 950 960
pF1KB7 QPAS-VNIP-GSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVAS
. : .: : : . : :.: :.:: ::::::.::..:::.::::::::::.::::.:.
XP_005 SSAPPANPPSGLMNPSLPFTSSPDPTPSQNPLSLMMTQMSKYAMPSSTPLYHNAIKTIAT
1020 1030 1040 1050 1060 1070
970 980 990 1000
pF1KB7 SDDDSPPARS---PNLPSMNNMPGPNPVVP-------MPTLSPMGMT----QPLSHS---
:::. : : : : ... :: . : . :::::. :::::
XP_005 SDDELLPDRPLLPPPPPPQGSGPGISNSQPSQMHLNSAAAQSPMGMNLPGQQPLSHEPPP
1080 1090 1100 1110 1120 1130
1010 1020 1030 1040 1050
pF1KB7 NQMPSPNAVGPNIPPHGVPMGPGLMSHNPIM----GHGSQEPPM--VPQGRMGFPQGFPP
..:::. .: ::: : .: : .: .: : : . : ::.. . .: :::
XP_005 AMLPSPTPLGSNIPLHPNAQGTGGPPQNSMMMAPGGPDSLNAPCGPVPSSSQMMP--FPP
1140 1150 1160 1170 1180 1190
1060 1070 1080 1090 1100 1110
pF1KB7 VQSPPQQVPFPHNGPSGGQG---SFPGGMGFPGEG-PLGRPSNLP--QSSADAALCKPGG
. :. . : .: .:: : .:.::..: : : :. .: : :. :
XP_005 RLQQPHGAMAPTGGGGGGPGLQQHYPSGMALPPEDLPNQPPGPMPPQQHLMGKAMAGRMG
1200 1210 1220 1230 1240 1250
1120 1130 1140 1150 1160 1170
pF1KB7 PGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQMLQYFPRGEV
. : . :: . . ::..::.:.::::: ::::::::::::::::::. :::::..:
XP_005 DAYPPG--VLPG-VASVLNDPELSEVIRPTPTGIPEFDLSRIIPSEKPSSTLQYFPKSEN
1260 1270 1280 1290 1300 1310
1180 1190 1200 1210 1220
pF1KB7 -PGRKQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSM--PGHN
: . :: :. . ..:.::.::.: :::. : . : :: ::.
XP_005 QPPKAQP--PNLHLMNLQNMMAEQTPSRPPNLPGQQG--------VQRGLNMSMCHPGQM
1320 1330 1340 1350 1360
1230 1240 1250 1260 1270 1280
pF1KB7 PM--RPPAFLQQGMM--GPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAG-LY
. : . ::::. : :. .::: :. : : .. :.:: .: .:
XP_005 SLLGRTGVPPQQGMVPHGLHQGVMSPPQGLMTQQNFMLM-----------KQRGVGGEVY
1370 1380 1390 1400
1290 1300 1310 1320 1330 1340
pF1KB7 THPGPVGSPGMMMSMQGMMGP--QQNIMIPPQMRPRGMAADVGMGGFSQGPGNPGNMMF
..: : :. . ..::: :::.:. .: :... : :: . .::
XP_005 SQP-----PHMLSPQGSLMGPPPQQNLMVSHPLRQRSVSLDSQMG-YLPAPGGMANLPF
1410 1420 1430 1440 1450 1460
>>XP_005271569 (OMIM: 609004) PREDICTED: B-cell CLL/lymp (1462 aa)
initn: 980 init1: 262 opt: 1263 Z-score: 476.5 bits: 100.7 E(85289): 8.4e-20
Smith-Waterman score: 2523; 37.8% identity (59.1% similar) in 1462 aa overlap (3-1333:84-1455)
10 20
pF1KB7 MHSSNPKVRSSPSGNTQS---SPKSKQE-VMV
:.. . ..:: .... .:.::.. :.
XP_005 NSSLKNPQAGVPPFSSLKGKVKRDRSVSVDSGEQREAGTPSLDSEAKEVAPRSKRRCVLE
60 70 80 90 100 110
30 40 50 60 70 80
pF1KB7 RPPTVMSPSGNPQLDSKFSNQECNSADHIKSQDSQHTPHSMTPSNATA-P--RSSTPS--
: . ::. ... ... . . : . .. :...: : .::.:.
XP_005 RKQPYSGDEWCSGPDSEEDDKPIGATHNCNVADPAMAAPQLGPGQTTQLPLSESSVPGAP
120 130 140 150 160 170
90 100 110 120 130
pF1KB7 HGQTTATEP-TPAQ---------KTPAKVVYVFSTEMANKAAEAVLKGQVETIVSFHIQN
:: . .: .:. : :.. ::::.:..:: ::::::.:....:...: ::
XP_005 HGPPPGLRPDAPGGGGGGGGVPGKPPSQFVYVFTTHLANTAAEAVLQGRADSILAYHQQN
180 190 200 210 220 230
140 150 160 170 180 190
pF1KB7 ISNNKTERSTAPLNTQISALRNDPKPLPQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKP
. : .. :: . :.::: . :. :. : :: : :: : :::
XP_005 VPRAKLDQ--AP------KVPPTPEPLPLSTPS-AGTPQ--SQPP---PLPPPPPPAPGS
240 250 260 270
200 210 220 230 240 250
pF1KB7 AAPPRPLDRESPGVENKLIP-SVGSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSA
: : : . . : : ::: :.:: :: ::. . : .:. :.. :::
XP_005 APPALPPEGPPEDSSQDLAPNSVG--AASTGGGTGGTHPNTPTATTANNPLPPGGDPSSA
280 290 300 310 320 330
260 270 280 290 300
pF1KB7 DPKAPPPPPVSSGEPPTLGE----NPDGLSQEQLEHRERSLQTLRDIQRMLF-PDEKE-F
: : .. . : :. . .:::.::::::::::::::::.:.:. : : :
XP_005 ----PGPALLGEAAAPGNGQRSLVGSEGLSKEQLEHRERSLQTLRDIERLLLRSGETEPF
340 350 360 370 380 390
310 320 330 340 350
pF1KB7 T-----GAQSGGP--------QQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGPGPRTDVG
:: ::: :: : . . :: : :.:.:..:.:::: :: .
XP_005 LKGPPGGAGEGGPPAQAPPPPQQPPTAPPSGLKKYEEPLQSMISQTQSLG---GPPLEHE
400 410 420 430 440 450
360 370 380 390 400 410
pF1KB7 APFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQ
.: :: : . : . .:: . .: : : ::::.:: :::.:.:::::::.
XP_005 VP----GH---PPGGD--MGQQMNMMIQRLGQDSL---TPEQVAWRKLQEEYYEEKRRKE
460 470 480 490
420 430 440 450 460 470
pF1KB7 EQVVVQQCS-LQDMMVHQHGPRGV-VRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLP
::. .. ::::: : :. ::::::::. :.. : :: . ... .
XP_005 EQIGLHGSRPLQDMM----GMGGMMVRGPPPPYHSKPGDQWPPGMGAQLRGPMDVQDPMQ
500 510 520 530 540 550
480 490 500 510 520
pF1KB7 PRGMAPHPN--MPGSQM-RLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDG
:: : :. .::.:. :.:::.:: . :: : : .:: :..: .:.: .
XP_005 LRGGPPFPGPRFPGNQIQRVPGFGGMQSMPMEVPM--NAMQRPVRPGMGWTEDLPPMGGP
560 570 580 590 600 610
530 540 550 560 570 580
pF1KB7 RNFPPGQGIF-SGPGRGERFPNPQGLSEEMFQQQLAEKQ-LGL--PPGMAMEGIRPSMEM
:: . . .: :..::: .:. . ::....:: ::. .:. : ::: :. ::::
XP_005 SNFAQNTMPYPGGQGEAERFMTPR-VREELLRHQLLEKRSMGMQRPLGMAGSGMGQSMEM
620 630 640 650 660 670
590 600 610 620 630
pF1KB7 NRMIPGSQRHMEPGNNPIFPRIPVEGPL---SPSRGDFPKG---IPPQMGPG--RELEFG
.::. ..:.:.:. .:: . : .: .: : . : :: . ::..
XP_005 ERMMQ-AHRQMDPA---MFPGQMAGGEGLAGTPMGMEFGGGRGLLSPPMGQSGLREVDPP
680 690 700 710 720
640 650 660 670
pF1KB7 MVPSG--MKGDVNLNVNMGSNSQMIPQ-------KMR-------EAGAGPEEMLKLRP-G
: :.. :. .::.:.::. : :: :: ::: : .:::: ..: .
XP_005 MGPGNLNMNMNVNMNMNMNLNVQMTPQQQMLMSQKMRGPGDLMGPQGLSPEEMARVRAQN
730 740 750 760 770 780
680 690 700 710 720 730
pF1KB7 GSDMLPAQQKMV-PLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRT--
.: .. . :::. : : .. :: .. : :. ::: : : .. ..::: .
XP_005 SSGVMGGPQKMLMPSQFPNQGQQGFSGGQGPYQAMSQDMG------NTQDMFSPDQSSMP
790 800 810 820 830 840
740 750 760 770 780 790
pF1KB7 -----NSRLSHMPPLPLNPSSNPT-SLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLK
..:::::: :: :.::: ....:: .:::::.: :.... .:. :::.. ::
XP_005 MSNVGTTRLSHMP-LP--PASNPPGTVHSAP--NRGLGRRPSDLTISINQMGSPGMGHLK
850 860 870 880 890
800 810 820 830 840
pF1KB7 SPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSA------AASP
:::. ::.::.. :::.::::::::::.. : . . .::: ::::. ..::
XP_005 SPTLSQVHSPLVTSPSANLKSPQTPSQMVP-LPSANPPGPLKSPQVLGSSLSVRSPTGSP
900 910 920 930 940 950
850 860 870 880 890 900
pF1KB7 VHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPP--PTAS
.:::::. .:::::..::: . :::. :.. ::.: : . :.:.:.: :: : .:
XP_005 SRLKSPSMAVPSPGWVASPKTAMPSPGVSQNKQPPLNMNSSTTLSNMEQGTLPPSGPRSS
960 970 980 990 1000 1010
910 920 930 940 950 960
pF1KB7 QPAS-VNIP-GSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVAS
. : .: : : . : :.: :.:: ::::::.::..:::.::::::::::.::::.:.
XP_005 SSAPPANPPSGLMNPSLPFTSSPDPTPSQNPLSLMMTQMSKYAMPSSTPLYHNAIKTIAT
1020 1030 1040 1050 1060 1070
970 980 990 1000
pF1KB7 SDDDSPPARS---PNLPSMNNMPGPNPVVP-------MPTLSPMGMT----QPLSHS---
:::. : : : : ... :: . : . :::::. :::::
XP_005 SDDELLPDRPLLPPPPPPQGSGPGISNSQPSQMHLNSAAAQSPMGMNLPGQQPLSHEPPP
1080 1090 1100 1110 1120 1130
1010 1020 1030 1040 1050
pF1KB7 NQMPSPNAVGPNIPPHGVPMGPGLMSHNPIM----GHGSQEPPM--VPQGRMGFPQGFPP
..:::. .: ::: : .: : .: .: : : . : ::.. . .: :::
XP_005 AMLPSPTPLGSNIPLHPNAQGTGGPPQNSMMMAPGGPDSLNAPCGPVPSSSQMMP--FPP
1140 1150 1160 1170 1180 1190
1060 1070 1080 1090 1100 1110
pF1KB7 VQSPPQQVPFPHNGPSGGQG---SFPGGMGFPGEG-PLGRPSNLP--QSSADAALCKPGG
. :. . : .: .:: : .:.::..: : : :. .: : :. :
XP_005 RLQQPHGAMAPTGGGGGGPGLQQHYPSGMALPPEDLPNQPPGPMPPQQHLMGKAMAGRMG
1200 1210 1220 1230 1240 1250
1120 1130 1140 1150 1160 1170
pF1KB7 PGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQMLQYFPRGEV
. : . :: . . ::..::.:.::::: ::::::::::::::::::. :::::..:
XP_005 DAYPPG--VLPG-VASVLNDPELSEVIRPTPTGIPEFDLSRIIPSEKPSSTLQYFPKSEN
1260 1270 1280 1290 1300 1310
1180 1190 1200 1210 1220
pF1KB7 -PGRKQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSM--PGHN
: . :: :. . ..:.::.::.: :::. : . : :: ::.
XP_005 QPPKAQP--PNLHLMNLQNMMAEQTPSRPPNLPGQQG--------VQRGLNMSMCHPGQM
1320 1330 1340 1350 1360
1230 1240 1250 1260 1270 1280
pF1KB7 PM--RPPAFLQQGMM--GPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAG-LY
. : . ::::. : :. .::: :. : : .. :.:: .: .:
XP_005 SLLGRTGVPPQQGMVPHGLHQGVMSPPQGLMTQQNFMLM-----------KQRGVGGEVY
1370 1380 1390 1400
1290 1300 1310 1320 1330 1340
pF1KB7 THPGPVGSPGMMMSMQGMMGP--QQNIMIPPQMRPRGMAADVGMGGFSQGPGNPGNMMF
..: : :. . ..::: :::.:. .: :... : :: . .::
XP_005 SQP-----PHMLSPQGSLMGPPPQQNLMVSHPLRQRSVSLDSQMG-YLPAPGGMANLPF
1410 1420 1430 1440 1450 1460
>>XP_006718878 (OMIM: 609004) PREDICTED: B-cell CLL/lymp (1499 aa)
initn: 980 init1: 262 opt: 1263 Z-score: 476.4 bits: 100.7 E(85289): 8.5e-20
Smith-Waterman score: 2523; 37.8% identity (59.1% similar) in 1462 aa overlap (3-1333:121-1492)
10 20
pF1KB7 MHSSNPKVRSSPSGNTQS---SPKSKQE-VMV
:.. . ..:: .... .:.::.. :.
XP_006 NSSLKNPQAGVPPFSSLKGKVKRDRSVSVDSGEQREAGTPSLDSEAKEVAPRSKRRCVLE
100 110 120 130 140 150
30 40 50 60 70 80
pF1KB7 RPPTVMSPSGNPQLDSKFSNQECNSADHIKSQDSQHTPHSMTPSNATA-P--RSSTPS--
: . ::. ... ... . . : . .. :...: : .::.:.
XP_006 RKQPYSGDEWCSGPDSEEDDKPIGATHNCNVADPAMAAPQLGPGQTTQLPLSESSVPGAP
160 170 180 190 200 210
90 100 110 120 130
pF1KB7 HGQTTATEP-TPAQ---------KTPAKVVYVFSTEMANKAAEAVLKGQVETIVSFHIQN
:: . .: .:. : :.. ::::.:..:: ::::::.:....:...: ::
XP_006 HGPPPGLRPDAPGGGGGGGGVPGKPPSQFVYVFTTHLANTAAEAVLQGRADSILAYHQQN
220 230 240 250 260 270
140 150 160 170 180 190
pF1KB7 ISNNKTERSTAPLNTQISALRNDPKPLPQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKP
. : .. :: . :.::: . :. :. : :: : :: : :::
XP_006 VPRAKLDQ--AP------KVPPTPEPLPLSTPS-AGTPQ--SQPP---PLPPPPPPAPGS
280 290 300 310
200 210 220 230 240 250
pF1KB7 AAPPRPLDRESPGVENKLIP-SVGSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSA
: : : . . : : ::: :.:: :: ::. . : .:. :.. :::
XP_006 APPALPPEGPPEDSSQDLAPNSVG--AASTGGGTGGTHPNTPTATTANNPLPPGGDPSSA
320 330 340 350 360 370
260 270 280 290 300
pF1KB7 DPKAPPPPPVSSGEPPTLGE----NPDGLSQEQLEHRERSLQTLRDIQRMLF-PDEKE-F
: : .. . : :. . .:::.::::::::::::::::.:.:. : : :
XP_006 ----PGPALLGEAAAPGNGQRSLVGSEGLSKEQLEHRERSLQTLRDIERLLLRSGETEPF
380 390 400 410 420 430
310 320 330 340 350
pF1KB7 T-----GAQSGGP--------QQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGPGPRTDVG
:: ::: :: : . . :: : :.:.:..:.:::: :: .
XP_006 LKGPPGGAGEGGPPAQAPPPPQQPPTAPPSGLKKYEEPLQSMISQTQSLG---GPPLEHE
440 450 460 470 480
360 370 380 390 400 410
pF1KB7 APFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQ
.: :: : . : . .:: . .: : : ::::.:: :::.:.:::::::.
XP_006 VP----GH---PPGGD--MGQQMNMMIQRLGQDSL---TPEQVAWRKLQEEYYEEKRRKE
490 500 510 520 530
420 430 440 450 460 470
pF1KB7 EQVVVQQCS-LQDMMVHQHGPRGV-VRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLP
::. .. ::::: : :. ::::::::. :.. : :: . ... .
XP_006 EQIGLHGSRPLQDMM----GMGGMMVRGPPPPYHSKPGDQWPPGMGAQLRGPMDVQDPMQ
540 550 560 570 580 590
480 490 500 510 520
pF1KB7 PRGMAPHPN--MPGSQM-RLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDG
:: : :. .::.:. :.:::.:: . :: : : .:: :..: .:.: .
XP_006 LRGGPPFPGPRFPGNQIQRVPGFGGMQSMPMEVPM--NAMQRPVRPGMGWTEDLPPMGGP
600 610 620 630 640
530 540 550 560 570 580
pF1KB7 RNFPPGQGIF-SGPGRGERFPNPQGLSEEMFQQQLAEKQ-LGL--PPGMAMEGIRPSMEM
:: . . .: :..::: .:. . ::....:: ::. .:. : ::: :. ::::
XP_006 SNFAQNTMPYPGGQGEAERFMTPR-VREELLRHQLLEKRSMGMQRPLGMAGSGMGQSMEM
650 660 670 680 690 700
590 600 610 620 630
pF1KB7 NRMIPGSQRHMEPGNNPIFPRIPVEGPL---SPSRGDFPKG---IPPQMGPG--RELEFG
.::. ..:.:.:. .:: . : .: .: : . : :: . ::..
XP_006 ERMMQ-AHRQMDPA---MFPGQMAGGEGLAGTPMGMEFGGGRGLLSPPMGQSGLREVDPP
710 720 730 740 750 760
640 650 660 670
pF1KB7 MVPSG--MKGDVNLNVNMGSNSQMIPQ-------KMR-------EAGAGPEEMLKLRP-G
: :.. :. .::.:.::. : :: :: ::: : .:::: ..: .
XP_006 MGPGNLNMNMNVNMNMNMNLNVQMTPQQQMLMSQKMRGPGDLMGPQGLSPEEMARVRAQN
770 780 790 800 810 820
680 690 700 710 720 730
pF1KB7 GSDMLPAQQKMV-PLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRT--
.: .. . :::. : : .. :: .. : :. ::: : : .. ..::: .
XP_006 SSGVMGGPQKMLMPSQFPNQGQQGFSGGQGPYQAMSQDMG------NTQDMFSPDQSSMP
830 840 850 860 870
740 750 760 770 780 790
pF1KB7 -----NSRLSHMPPLPLNPSSNPT-SLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLK
..:::::: :: :.::: ....:: .:::::.: :.... .:. :::.. ::
XP_006 MSNVGTTRLSHMP-LP--PASNPPGTVHSAP--NRGLGRRPSDLTISINQMGSPGMGHLK
880 890 900 910 920 930
800 810 820 830 840
pF1KB7 SPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSA------AASP
:::. ::.::.. :::.::::::::::.. : . . .::: ::::. ..::
XP_006 SPTLSQVHSPLVTSPSANLKSPQTPSQMVP-LPSANPPGPLKSPQVLGSSLSVRSPTGSP
940 950 960 970 980 990
850 860 870 880 890 900
pF1KB7 VHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPP--PTAS
.:::::. .:::::..::: . :::. :.. ::.: : . :.:.:.: :: : .:
XP_006 SRLKSPSMAVPSPGWVASPKTAMPSPGVSQNKQPPLNMNSSTTLSNMEQGTLPPSGPRSS
1000 1010 1020 1030 1040 1050
910 920 930 940 950 960
pF1KB7 QPAS-VNIP-GSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVAS
. : .: : : . : :.: :.:: ::::::.::..:::.::::::::::.::::.:.
XP_006 SSAPPANPPSGLMNPSLPFTSSPDPTPSQNPLSLMMTQMSKYAMPSSTPLYHNAIKTIAT
1060 1070 1080 1090 1100 1110
970 980 990 1000
pF1KB7 SDDDSPPARS---PNLPSMNNMPGPNPVVP-------MPTLSPMGMT----QPLSHS---
:::. : : : : ... :: . : . :::::. :::::
XP_006 SDDELLPDRPLLPPPPPPQGSGPGISNSQPSQMHLNSAAAQSPMGMNLPGQQPLSHEPPP
1120 1130 1140 1150 1160 1170
1010 1020 1030 1040 1050
pF1KB7 NQMPSPNAVGPNIPPHGVPMGPGLMSHNPIM----GHGSQEPPM--VPQGRMGFPQGFPP
..:::. .: ::: : .: : .: .: : : . : ::.. . .: :::
XP_006 AMLPSPTPLGSNIPLHPNAQGTGGPPQNSMMMAPGGPDSLNAPCGPVPSSSQMMP--FPP
1180 1190 1200 1210 1220 1230
1060 1070 1080 1090 1100 1110
pF1KB7 VQSPPQQVPFPHNGPSGGQG---SFPGGMGFPGEG-PLGRPSNLP--QSSADAALCKPGG
. :. . : .: .:: : .:.::..: : : :. .: : :. :
XP_006 RLQQPHGAMAPTGGGGGGPGLQQHYPSGMALPPEDLPNQPPGPMPPQQHLMGKAMAGRMG
1240 1250 1260 1270 1280 1290
1120 1130 1140 1150 1160 1170
pF1KB7 PGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQMLQYFPRGEV
. : . :: . . ::..::.:.::::: ::::::::::::::::::. :::::..:
XP_006 DAYPPG--VLPG-VASVLNDPELSEVIRPTPTGIPEFDLSRIIPSEKPSSTLQYFPKSEN
1300 1310 1320 1330 1340
1180 1190 1200 1210 1220
pF1KB7 -PGRKQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSM--PGHN
: . :: :. . ..:.::.::.: :::. : . : :: ::.
XP_006 QPPKAQP--PNLHLMNLQNMMAEQTPSRPPNLPGQQG--------VQRGLNMSMCHPGQM
1350 1360 1370 1380 1390
1230 1240 1250 1260 1270 1280
pF1KB7 PM--RPPAFLQQGMM--GPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAG-LY
. : . ::::. : :. .::: :. : : .. :.:: .: .:
XP_006 SLLGRTGVPPQQGMVPHGLHQGVMSPPQGLMTQQNFMLM-----------KQRGVGGEVY
1400 1410 1420 1430 1440
1290 1300 1310 1320 1330 1340
pF1KB7 THPGPVGSPGMMMSMQGMMGP--QQNIMIPPQMRPRGMAADVGMGGFSQGPGNPGNMMF
..: : :. . ..::: :::.:. .: :... : :: . .::
XP_006 SQP-----PHMLSPQGSLMGPPPQQNLMVSHPLRQRSVSLDSQMG-YLPAPGGMANLPF
1450 1460 1470 1480 1490
>>XP_005271568 (OMIM: 609004) PREDICTED: B-cell CLL/lymp (1499 aa)
initn: 980 init1: 262 opt: 1263 Z-score: 476.4 bits: 100.7 E(85289): 8.5e-20
Smith-Waterman score: 2523; 37.8% identity (59.1% similar) in 1462 aa overlap (3-1333:121-1492)
10 20
pF1KB7 MHSSNPKVRSSPSGNTQS---SPKSKQE-VMV
:.. . ..:: .... .:.::.. :.
XP_005 NSSLKNPQAGVPPFSSLKGKVKRDRSVSVDSGEQREAGTPSLDSEAKEVAPRSKRRCVLE
100 110 120 130 140 150
30 40 50 60 70 80
pF1KB7 RPPTVMSPSGNPQLDSKFSNQECNSADHIKSQDSQHTPHSMTPSNATA-P--RSSTPS--
: . ::. ... ... . . : . .. :...: : .::.:.
XP_005 RKQPYSGDEWCSGPDSEEDDKPIGATHNCNVADPAMAAPQLGPGQTTQLPLSESSVPGAP
160 170 180 190 200 210
90 100 110 120 130
pF1KB7 HGQTTATEP-TPAQ---------KTPAKVVYVFSTEMANKAAEAVLKGQVETIVSFHIQN
:: . .: .:. : :.. ::::.:..:: ::::::.:....:...: ::
XP_005 HGPPPGLRPDAPGGGGGGGGVPGKPPSQFVYVFTTHLANTAAEAVLQGRADSILAYHQQN
220 230 240 250 260 270
140 150 160 170 180 190
pF1KB7 ISNNKTERSTAPLNTQISALRNDPKPLPQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKP
. : .. :: . :.::: . :. :. : :: : :: : :::
XP_005 VPRAKLDQ--AP------KVPPTPEPLPLSTPS-AGTPQ--SQPP---PLPPPPPPAPGS
280 290 300 310
200 210 220 230 240 250
pF1KB7 AAPPRPLDRESPGVENKLIP-SVGSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSA
: : : . . : : ::: :.:: :: ::. . : .:. :.. :::
XP_005 APPALPPEGPPEDSSQDLAPNSVG--AASTGGGTGGTHPNTPTATTANNPLPPGGDPSSA
320 330 340 350 360 370
260 270 280 290 300
pF1KB7 DPKAPPPPPVSSGEPPTLGE----NPDGLSQEQLEHRERSLQTLRDIQRMLF-PDEKE-F
: : .. . : :. . .:::.::::::::::::::::.:.:. : : :
XP_005 ----PGPALLGEAAAPGNGQRSLVGSEGLSKEQLEHRERSLQTLRDIERLLLRSGETEPF
380 390 400 410 420 430
310 320 330 340 350
pF1KB7 T-----GAQSGGP--------QQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGPGPRTDVG
:: ::: :: : . . :: : :.:.:..:.:::: :: .
XP_005 LKGPPGGAGEGGPPAQAPPPPQQPPTAPPSGLKKYEEPLQSMISQTQSLG---GPPLEHE
440 450 460 470 480
360 370 380 390 400 410
pF1KB7 APFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQ
.: :: : . : . .:: . .: : : ::::.:: :::.:.:::::::.
XP_005 VP----GH---PPGGD--MGQQMNMMIQRLGQDSL---TPEQVAWRKLQEEYYEEKRRKE
490 500 510 520 530
420 430 440 450 460 470
pF1KB7 EQVVVQQCS-LQDMMVHQHGPRGV-VRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLP
::. .. ::::: : :. ::::::::. :.. : :: . ... .
XP_005 EQIGLHGSRPLQDMM----GMGGMMVRGPPPPYHSKPGDQWPPGMGAQLRGPMDVQDPMQ
540 550 560 570 580 590
480 490 500 510 520
pF1KB7 PRGMAPHPN--MPGSQM-RLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDG
:: : :. .::.:. :.:::.:: . :: : : .:: :..: .:.: .
XP_005 LRGGPPFPGPRFPGNQIQRVPGFGGMQSMPMEVPM--NAMQRPVRPGMGWTEDLPPMGGP
600 610 620 630 640
530 540 550 560 570 580
pF1KB7 RNFPPGQGIF-SGPGRGERFPNPQGLSEEMFQQQLAEKQ-LGL--PPGMAMEGIRPSMEM
:: . . .: :..::: .:. . ::....:: ::. .:. : ::: :. ::::
XP_005 SNFAQNTMPYPGGQGEAERFMTPR-VREELLRHQLLEKRSMGMQRPLGMAGSGMGQSMEM
650 660 670 680 690 700
590 600 610 620 630
pF1KB7 NRMIPGSQRHMEPGNNPIFPRIPVEGPL---SPSRGDFPKG---IPPQMGPG--RELEFG
.::. ..:.:.:. .:: . : .: .: : . : :: . ::..
XP_005 ERMMQ-AHRQMDPA---MFPGQMAGGEGLAGTPMGMEFGGGRGLLSPPMGQSGLREVDPP
710 720 730 740 750 760
640 650 660 670
pF1KB7 MVPSG--MKGDVNLNVNMGSNSQMIPQ-------KMR-------EAGAGPEEMLKLRP-G
: :.. :. .::.:.::. : :: :: ::: : .:::: ..: .
XP_005 MGPGNLNMNMNVNMNMNMNLNVQMTPQQQMLMSQKMRGPGDLMGPQGLSPEEMARVRAQN
770 780 790 800 810 820
680 690 700 710 720 730
pF1KB7 GSDMLPAQQKMV-PLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRT--
.: .. . :::. : : .. :: .. : :. ::: : : .. ..::: .
XP_005 SSGVMGGPQKMLMPSQFPNQGQQGFSGGQGPYQAMSQDMG------NTQDMFSPDQSSMP
830 840 850 860 870
740 750 760 770 780 790
pF1KB7 -----NSRLSHMPPLPLNPSSNPT-SLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLK
..:::::: :: :.::: ....:: .:::::.: :.... .:. :::.. ::
XP_005 MSNVGTTRLSHMP-LP--PASNPPGTVHSAP--NRGLGRRPSDLTISINQMGSPGMGHLK
880 890 900 910 920 930
800 810 820 830 840
pF1KB7 SPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSA------AASP
:::. ::.::.. :::.::::::::::.. : . . .::: ::::. ..::
XP_005 SPTLSQVHSPLVTSPSANLKSPQTPSQMVP-LPSANPPGPLKSPQVLGSSLSVRSPTGSP
940 950 960 970 980 990
850 860 870 880 890 900
pF1KB7 VHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPP--PTAS
.:::::. .:::::..::: . :::. :.. ::.: : . :.:.:.: :: : .:
XP_005 SRLKSPSMAVPSPGWVASPKTAMPSPGVSQNKQPPLNMNSSTTLSNMEQGTLPPSGPRSS
1000 1010 1020 1030 1040 1050
910 920 930 940 950 960
pF1KB7 QPAS-VNIP-GSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVAS
. : .: : : . : :.: :.:: ::::::.::..:::.::::::::::.::::.:.
XP_005 SSAPPANPPSGLMNPSLPFTSSPDPTPSQNPLSLMMTQMSKYAMPSSTPLYHNAIKTIAT
1060 1070 1080 1090 1100 1110
970 980 990 1000
pF1KB7 SDDDSPPARS---PNLPSMNNMPGPNPVVP-------MPTLSPMGMT----QPLSHS---
:::. : : : : ... :: . : . :::::. :::::
XP_005 SDDELLPDRPLLPPPPPPQGSGPGISNSQPSQMHLNSAAAQSPMGMNLPGQQPLSHEPPP
1120 1130 1140 1150 1160 1170
1010 1020 1030 1040 1050
pF1KB7 NQMPSPNAVGPNIPPHGVPMGPGLMSHNPIM----GHGSQEPPM--VPQGRMGFPQGFPP
..:::. .: ::: : .: : .: .: : : . : ::.. . .: :::
XP_005 AMLPSPTPLGSNIPLHPNAQGTGGPPQNSMMMAPGGPDSLNAPCGPVPSSSQMMP--FPP
1180 1190 1200 1210 1220 1230
1060 1070 1080 1090 1100 1110
pF1KB7 VQSPPQQVPFPHNGPSGGQG---SFPGGMGFPGEG-PLGRPSNLP--QSSADAALCKPGG
. :. . : .: .:: : .:.::..: : : :. .: : :. :
XP_005 RLQQPHGAMAPTGGGGGGPGLQQHYPSGMALPPEDLPNQPPGPMPPQQHLMGKAMAGRMG
1240 1250 1260 1270 1280 1290
1120 1130 1140 1150 1160 1170
pF1KB7 PGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQMLQYFPRGEV
. : . :: . . ::..::.:.::::: ::::::::::::::::::. :::::..:
XP_005 DAYPPG--VLPG-VASVLNDPELSEVIRPTPTGIPEFDLSRIIPSEKPSSTLQYFPKSEN
1300 1310 1320 1330 1340
1180 1190 1200 1210 1220
pF1KB7 -PGRKQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSM--PGHN
: . :: :. . ..:.::.::.: :::. : . : :: ::.
XP_005 QPPKAQP--PNLHLMNLQNMMAEQTPSRPPNLPGQQG--------VQRGLNMSMCHPGQM
1350 1360 1370 1380 1390
1230 1240 1250 1260 1270 1280
pF1KB7 PM--RPPAFLQQGMM--GPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAG-LY
. : . ::::. : :. .::: :. : : .. :.:: .: .:
XP_005 SLLGRTGVPPQQGMVPHGLHQGVMSPPQGLMTQQNFMLM-----------KQRGVGGEVY
1400 1410 1420 1430 1440
1290 1300 1310 1320 1330 1340
pF1KB7 THPGPVGSPGMMMSMQGMMGP--QQNIMIPPQMRPRGMAADVGMGGFSQGPGNPGNMMF
..: : :. . ..::: :::.:. .: :... : :: . .::
XP_005 SQP-----PHMLSPQGSLMGPPPQQNLMVSHPLRQRSVSLDSQMG-YLPAPGGMANLPF
1450 1460 1470 1480 1490
>>NP_872363 (OMIM: 609004) B-cell CLL/lymphoma 9-like pr (1499 aa)
initn: 980 init1: 262 opt: 1263 Z-score: 476.4 bits: 100.7 E(85289): 8.5e-20
Smith-Waterman score: 2523; 37.8% identity (59.1% similar) in 1462 aa overlap (3-1333:121-1492)
10 20
pF1KB7 MHSSNPKVRSSPSGNTQS---SPKSKQE-VMV
:.. . ..:: .... .:.::.. :.
NP_872 NSSLKNPQAGVPPFSSLKGKVKRDRSVSVDSGEQREAGTPSLDSEAKEVAPRSKRRCVLE
100 110 120 130 140 150
30 40 50 60 70 80
pF1KB7 RPPTVMSPSGNPQLDSKFSNQECNSADHIKSQDSQHTPHSMTPSNATA-P--RSSTPS--
: . ::. ... ... . . : . .. :...: : .::.:.
NP_872 RKQPYSGDEWCSGPDSEEDDKPIGATHNCNVADPAMAAPQLGPGQTTQLPLSESSVPGAP
160 170 180 190 200 210
90 100 110 120 130
pF1KB7 HGQTTATEP-TPAQ---------KTPAKVVYVFSTEMANKAAEAVLKGQVETIVSFHIQN
:: . .: .:. : :.. ::::.:..:: ::::::.:....:...: ::
NP_872 HGPPPGLRPDAPGGGGGGGGVPGKPPSQFVYVFTTHLANTAAEAVLQGRADSILAYHQQN
220 230 240 250 260 270
140 150 160 170 180 190
pF1KB7 ISNNKTERSTAPLNTQISALRNDPKPLPQQPPAPANQDQNSSQNTRLQPTPPIPAPAPKP
. : .. :: . :.::: . :. :. : :: : :: : :::
NP_872 VPRAKLDQ--AP------KVPPTPEPLPLSTPS-AGTPQ--SQPP---PLPPPPPPAPGS
280 290 300 310
200 210 220 230 240 250
pF1KB7 AAPPRPLDRESPGVENKLIP-SVGSPASSTPLPPDGTGPNSTPNNRAVTPVSQGSNSSSA
: : : . . : : ::: :.:: :: ::. . : .:. :.. :::
NP_872 APPALPPEGPPEDSSQDLAPNSVG--AASTGGGTGGTHPNTPTATTANNPLPPGGDPSSA
320 330 340 350 360 370
260 270 280 290 300
pF1KB7 DPKAPPPPPVSSGEPPTLGE----NPDGLSQEQLEHRERSLQTLRDIQRMLF-PDEKE-F
: : .. . : :. . .:::.::::::::::::::::.:.:. : : :
NP_872 ----PGPALLGEAAAPGNGQRSLVGSEGLSKEQLEHRERSLQTLRDIERLLLRSGETEPF
380 390 400 410 420 430
310 320 330 340 350
pF1KB7 T-----GAQSGGP--------QQNPGVLDGPQKKPEGPIQAMMAQSQSLGKGPGPRTDVG
:: ::: :: : . . :: : :.:.:..:.:::: :: .
NP_872 LKGPPGGAGEGGPPAQAPPPPQQPPTAPPSGLKKYEEPLQSMISQTQSLG---GPPLEHE
440 450 460 470 480
360 370 380 390 400 410
pF1KB7 APFGPQGHRDVPFSPDEMVPPSMNSQSGTIGPDHLDHMTPEQIAWLKLQQEFYEEKRRKQ
.: :: : . : . .:: . .: : : ::::.:: :::.:.:::::::.
NP_872 VP----GH---PPGGD--MGQQMNMMIQRLGQDSL---TPEQVAWRKLQEEYYEEKRRKE
490 500 510 520 530
420 430 440 450 460 470
pF1KB7 EQVVVQQCS-LQDMMVHQHGPRGV-VRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLP
::. .. ::::: : :. ::::::::. :.. : :: . ... .
NP_872 EQIGLHGSRPLQDMM----GMGGMMVRGPPPPYHSKPGDQWPPGMGAQLRGPMDVQDPMQ
540 550 560 570 580 590
480 490 500 510 520
pF1KB7 PRGMAPHPN--MPGSQM-RLPGFAGMINSEMEGPNVPNPASRPGLSGVSWPDDVPKIPDG
:: : :. .::.:. :.:::.:: . :: : : .:: :..: .:.: .
NP_872 LRGGPPFPGPRFPGNQIQRVPGFGGMQSMPMEVPM--NAMQRPVRPGMGWTEDLPPMGGP
600 610 620 630 640
530 540 550 560 570 580
pF1KB7 RNFPPGQGIF-SGPGRGERFPNPQGLSEEMFQQQLAEKQ-LGL--PPGMAMEGIRPSMEM
:: . . .: :..::: .:. . ::....:: ::. .:. : ::: :. ::::
NP_872 SNFAQNTMPYPGGQGEAERFMTPR-VREELLRHQLLEKRSMGMQRPLGMAGSGMGQSMEM
650 660 670 680 690 700
590 600 610 620 630
pF1KB7 NRMIPGSQRHMEPGNNPIFPRIPVEGPL---SPSRGDFPKG---IPPQMGPG--RELEFG
.::. ..:.:.:. .:: . : .: .: : . : :: . ::..
NP_872 ERMMQ-AHRQMDPA---MFPGQMAGGEGLAGTPMGMEFGGGRGLLSPPMGQSGLREVDPP
710 720 730 740 750 760
640 650 660 670
pF1KB7 MVPSG--MKGDVNLNVNMGSNSQMIPQ-------KMR-------EAGAGPEEMLKLRP-G
: :.. :. .::.:.::. : :: :: ::: : .:::: ..: .
NP_872 MGPGNLNMNMNVNMNMNMNLNVQMTPQQQMLMSQKMRGPGDLMGPQGLSPEEMARVRAQN
770 780 790 800 810 820
680 690 700 710 720 730
pF1KB7 GSDMLPAQQKMV-PLPFGEHPQQEYGMGPRPFLPMSQGPGSNSGLRNLREPIGPDQRT--
.: .. . :::. : : .. :: .. : :. ::: : : .. ..::: .
NP_872 SSGVMGGPQKMLMPSQFPNQGQQGFSGGQGPYQAMSQDMG------NTQDMFSPDQSSMP
830 840 850 860 870
740 750 760 770 780 790
pF1KB7 -----NSRLSHMPPLPLNPSSNPT-SLNTAPPVQRGLGRKPLDISVAGSQVHSPGINPLK
..:::::: :: :.::: ....:: .:::::.: :.... .:. :::.. ::
NP_872 MSNVGTTRLSHMP-LP--PASNPPGTVHSAP--NRGLGRRPSDLTISINQMGSPGMGHLK
880 890 900 910 920 930
800 810 820 830 840
pF1KB7 SPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSA------AASP
:::. ::.::.. :::.::::::::::.. : . . .::: ::::. ..::
NP_872 SPTLSQVHSPLVTSPSANLKSPQTPSQMVP-LPSANPPGPLKSPQVLGSSLSVRSPTGSP
940 950 960 970 980 990
850 860 870 880 890 900
pF1KB7 VHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAMLGNVESGGPPP--PTAS
.:::::. .:::::..::: . :::. :.. ::.: : . :.:.:.: :: : .:
NP_872 SRLKSPSMAVPSPGWVASPKTAMPSPGVSQNKQPPLNMNSSTTLSNMEQGTLPPSGPRSS
1000 1010 1020 1030 1040 1050
910 920 930 940 950 960
pF1KB7 QPAS-VNIP-GSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVAS
. : .: : : . : :.: :.:: ::::::.::..:::.::::::::::.::::.:.
NP_872 SSAPPANPPSGLMNPSLPFTSSPDPTPSQNPLSLMMTQMSKYAMPSSTPLYHNAIKTIAT
1060 1070 1080 1090 1100 1110
970 980 990 1000
pF1KB7 SDDDSPPARS---PNLPSMNNMPGPNPVVP-------MPTLSPMGMT----QPLSHS---
:::. : : : : ... :: . : . :::::. :::::
NP_872 SDDELLPDRPLLPPPPPPQGSGPGISNSQPSQMHLNSAAAQSPMGMNLPGQQPLSHEPPP
1120 1130 1140 1150 1160 1170
1010 1020 1030 1040 1050
pF1KB7 NQMPSPNAVGPNIPPHGVPMGPGLMSHNPIM----GHGSQEPPM--VPQGRMGFPQGFPP
..:::. .: ::: : .: : .: .: : : . : ::.. . .: :::
NP_872 AMLPSPTPLGSNIPLHPNAQGTGGPPQNSMMMAPGGPDSLNAPCGPVPSSSQMMP--FPP
1180 1190 1200 1210 1220 1230
1060 1070 1080 1090 1100 1110
pF1KB7 VQSPPQQVPFPHNGPSGGQG---SFPGGMGFPGEG-PLGRPSNLP--QSSADAALCKPGG
. :. . : .: .:: : .:.::..: : : :. .: : :. :
NP_872 RLQQPHGAMAPTGGGGGGPGLQQHYPSGMALPPEDLPNQPPGPMPPQQHLMGKAMAGRMG
1240 1250 1260 1270 1280 1290
1120 1130 1140 1150 1160 1170
pF1KB7 PGGPDSFTVLGNSMPSVFTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQMLQYFPRGEV
. : . :: . . ::..::.:.::::: ::::::::::::::::::. :::::..:
NP_872 DAYPPG--VLPG-VASVLNDPELSEVIRPTPTGIPEFDLSRIIPSEKPSSTLQYFPKSEN
1300 1310 1320 1330 1340
1180 1190 1200 1210 1220
pF1KB7 -PGRKQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGPGPVGTPDIPLGTAPSM--PGHN
: . :: :. . ..:.::.::.: :::. : . : :: ::.
NP_872 QPPKAQP--PNLHLMNLQNMMAEQTPSRPPNLPGQQG--------VQRGLNMSMCHPGQM
1350 1360 1370 1380 1390
1230 1240 1250 1260 1270 1280
pF1KB7 PM--RPPAFLQQGMM--GPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAG-LY
. : . ::::. : :. .::: :. : : .. :.:: .: .:
NP_872 SLLGRTGVPPQQGMVPHGLHQGVMSPPQGLMTQQNFMLM-----------KQRGVGGEVY
1400 1410 1420 1430 1440
1290 1300 1310 1320 1330 1340
pF1KB7 THPGPVGSPGMMMSMQGMMGP--QQNIMIPPQMRPRGMAADVGMGGFSQGPGNPGNMMF
..: : :. . ..::: :::.:. .: :... : :: . .::
NP_872 SQP-----PHMLSPQGSLMGPPPQQNLMVSHPLRQRSVSLDSQMG-YLPAPGGMANLPF
1450 1460 1470 1480 1490
1340 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 18:08:46 2016 done: Thu Nov 3 18:08:49 2016
Total Scan time: 20.740 Total Display time: 0.650
Function used was FASTA [36.3.4 Apr, 2011]