FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7035, 426 aa 1>>>pF1KB7035 426 - 426 aa - 426 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.0017+/-0.000702; mu= 14.8990+/- 0.042 mean_var=85.1099+/-16.514, 0's: 0 Z-trim(111.0): 36 B-trim: 13 in 1/51 Lambda= 0.139022 statistics sampled from 11982 (12018) to 11982 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.721), E-opt: 0.2 (0.369), width: 16 Scan time: 3.270 The best scores are: opt bits E(32554) CCDS5464.1 INHBA gene_id:3624|Hs108|chr7 ( 426) 2895 590.1 1.4e-168 CCDS2132.1 INHBB gene_id:3625|Hs108|chr2 ( 407) 700 149.8 4.4e-36 CCDS8938.1 INHBC gene_id:3626|Hs108|chr12 ( 352) 523 114.3 1.9e-25 CCDS8939.1 INHBE gene_id:83729|Hs108|chr12 ( 350) 500 109.7 4.6e-24 CCDS13099.1 BMP2 gene_id:650|Hs108|chr20 ( 396) 393 88.3 1.5e-17 CCDS8581.1 GDF3 gene_id:9573|Hs108|chr12 ( 364) 380 85.6 8.4e-17 CCDS34926.1 GDF6 gene_id:392255|Hs108|chr8 ( 455) 368 83.3 5.3e-16 CCDS437.1 BMP8A gene_id:353500|Hs108|chr1 ( 402) 361 81.9 1.3e-15 CCDS9715.1 BMP4 gene_id:652|Hs108|chr14 ( 408) 361 81.9 1.3e-15 CCDS444.1 BMP8B gene_id:656|Hs108|chr1 ( 402) 358 81.3 1.9e-15 CCDS42526.1 GDF1 gene_id:2657|Hs108|chr19 ( 372) 357 81.0 2.1e-15 CCDS4958.1 BMP5 gene_id:653|Hs108|chr6 ( 454) 344 78.5 1.5e-14 CCDS4503.1 BMP6 gene_id:654|Hs108|chr6 ( 513) 342 78.1 2.2e-14 CCDS13455.1 BMP7 gene_id:655|Hs108|chr20 ( 431) 340 77.7 2.5e-14 CCDS33031.1 TGFB1 gene_id:7040|Hs108|chr19 ( 390) 317 73.0 5.6e-13 CCDS9846.1 TGFB3 gene_id:7043|Hs108|chr14 ( 412) 317 73.0 5.9e-13 CCDS13254.1 GDF5 gene_id:8200|Hs108|chr20 ( 501) 317 73.1 7e-13 CCDS7304.1 NODAL gene_id:4838|Hs108|chr10 ( 347) 313 72.2 8.9e-13 CCDS1701.1 GDF7 gene_id:151449|Hs108|chr2 ( 450) 312 72.1 1.3e-12 CCDS3588.1 BMP3 gene_id:651|Hs108|chr4 ( 472) 299 69.5 8.1e-12 CCDS1521.1 TGFB2 gene_id:7042|Hs108|chr1 ( 414) 297 69.0 9.6e-12 CCDS44318.1 TGFB2 gene_id:7042|Hs108|chr1 ( 442) 297 69.0 1e-11 CCDS1890.1 BMP10 gene_id:27302|Hs108|chr2 ( 424) 293 68.2 1.7e-11 >>CCDS5464.1 INHBA gene_id:3624|Hs108|chr7 (426 aa) initn: 2895 init1: 2895 opt: 2895 Z-score: 3140.3 bits: 590.1 E(32554): 1.4e-168 Smith-Waterman score: 2895; 100.0% identity (100.0% similar) in 426 aa overlap (1-426:1-426) 10 20 30 40 50 60 pF1KB7 MPLLWLRGFLLASCWIIVRSSPTPGSEGHSAAPDCPSCALAALPKDVPNSQPEMVEAVKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 MPLLWLRGFLLASCWIIVRSSPTPGSEGHSAAPDCPSCALAALPKDVPNSQPEMVEAVKK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 HILNMLHLKKRPDVTQPVPKAALLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNELMEQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 HILNMLHLKKRPDVTQPVPKAALLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNELMEQT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 SEIITFAESGTARKTLHFEISKEGSDLSVVERAEVWLFLKVPKANRTRTKVTIRLFQQQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 SEIITFAESGTARKTLHFEISKEGSDLSVVERAEVWLFLKVPKANRTRTKVTIRLFQQQK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 HPQGSLDTGEEAEEVGLKGERSELLLSEKVVDARKSTWHVFPVSSSIQRLLDQGKSSLDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 HPQGSLDTGEEAEEVGLKGERSELLLSEKVVDARKSTWHVFPVSSSIQRLLDQGKSSLDV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 RIACEQCQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRPFLMLQARQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 RIACEQCQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRPFLMLQARQS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 EDHPHRRRRRGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 EDHPHRRRRRGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 TSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS54 TSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIV 370 380 390 400 410 420 pF1KB7 EECGCS :::::: CCDS54 EECGCS >>CCDS2132.1 INHBB gene_id:3625|Hs108|chr2 (407 aa) initn: 1151 init1: 437 opt: 700 Z-score: 761.3 bits: 149.8 E(32554): 4.4e-36 Smith-Waterman score: 1131; 43.3% identity (69.7% similar) in 413 aa overlap (22-426:43-407) 10 20 30 40 50 pF1KB7 MPLLWLRGFLLASCWIIVRSSPTPGSEGHSAAPDCPSCALAALPKDVPNSQ : ::: : : : ::. :... . CCDS21 CLLLLAAGWLGPEAWGSPTPPPTPAAPPPPPPPGSPGGSQ-DTCTSCGGFRRPEELGRVD 20 30 40 50 60 70 60 70 80 90 100 110 pF1KB7 PEMVEAVKKHILNMLHLKKRPDVTQPVPKAALLNAIRKLHVGKVGENGYVEIEDDIGRRA ...::::.:::. :... ::..:. :::::...:.::::.::: :.: ::: :. . CCDS21 GDFLEAVKRHILSRLQMRGRPNITHAVPKAAMVTALRKLHAGKVREDGRVEIPHLDGHAS 80 90 100 110 120 130 120 130 140 150 160 pF1KB7 EMNELMEQTSEIITFAES---GTARKTLHFEISKEGSDLSVVERAEVWLFLKV-P----K . .:..::::.:::. ...: :.: ::.::.. : .: .::.::. : : CCDS21 PGADGQERVSEIISFAETDGLASSRVRLYFFISNEGNQNLFVVQASLWLYLKLLPYVLEK 140 150 160 170 180 190 170 180 190 200 210 220 pF1KB7 ANRTRTKVTIRLFQQQKHPQGSLDTGEEAEEVGLKGERSELLLSEKVVDARKSTWHVFPV ..: ...: . ::.: : :.: ... :: :: ..: ::.::. CCDS21 GSRRKVRVKVY-FQEQGH-----------------GDRWNMV--EKRVDLKRSGWHTFPL 200 210 220 230 230 240 250 260 270 280 pF1KB7 SSSIQRLLDQGKSSLDVRIACEQCQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADE . .:: :...:. :.. . :..::: .. :.. . :: CCDS21 TEAIQALFERGERRLNLDVQCDSCQELAVVPVFV-------DPGE--------------- 240 250 260 290 300 310 320 330 340 pF1KB7 EKEQSHRPFLMLQARQSEDHPHRRRRRGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPS .:::::...::: . : :: :.:::::::..:.::..:::..:. ::::::::::. CCDS21 ---ESHRPFVVVQARLG-DSRHRIRKRGLECDGRTNLCCRQQFFIDFRLIGWNDWIIAPT 270 280 290 300 310 320 350 360 370 380 390 400 pF1KB7 GYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLY ::..::::: ::...::. ::. :::..:.:.::::: .: ....:::.:::: ::::: CCDS21 GYYGNYCEGSCPAYLAGVPGSASSFHTAVVNQYRMRGLNP-GTVNSCCIPTKLSTMSMLY 330 340 350 360 370 380 410 420 pF1KB7 YDDGQNIIKKDIQNMIVEECGCS .:: ::.:.:. :::::::::. CCDS21 FDDEYNIVKRDVPNMIVEECGCA 390 400 >>CCDS8938.1 INHBC gene_id:3626|Hs108|chr12 (352 aa) initn: 684 init1: 501 opt: 523 Z-score: 570.4 bits: 114.3 E(32554): 1.9e-25 Smith-Waterman score: 679; 32.6% identity (56.0% similar) in 423 aa overlap (9-426:5-352) 10 20 30 40 50 60 pF1KB7 MPLLWLRGFLLASCWIIVRSSPTPGSEGHSAAPDCPSCALAALPKDVPNSQPEMVEAVKK .::: . . :: . :. ::.:. .: .. ... ... .:. CCDS89 MTSSLLLAFLLLAPTTVATPRAGGQ-----CPACGGPTL--ELESQRELLLDLAKR 10 20 30 40 70 80 90 100 110 120 pF1KB7 HILNMLHLKKRPDVTQPVPKAALLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNELMEQT ::. ::: .:: ...:: .::: .:...:: : . .::. :: CCDS89 SILDKLHLTQRPTLNRPVSRAALRTALQHLH----GVPQGALLEDN----------REQE 50 60 70 80 90 130 140 150 160 170 pF1KB7 SEIITFAESGTA-----RKTLHFEISKEGSDLSVVERAEVWLFLKVPKANRTRTKVTIRL :::.:::.: . : .:: .. ..: : ..: . .:...:. . :: . CCDS89 CEIISFAETGLSTINQTRLDFHFSSDRTAGDREV-QQASLMFFVQLPSNTTWTLKVRV-- 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB7 FQQQKHPQGSLDTGEEAEEVGLKGERSELLLSEKVVDARKSTWHVFPVSSSIQRLLDQGK : : . .. : .. :: ::: : :: .:.. : .::. CCDS89 ----------LVLGPHNTNLTLA---TQYLLE---VDA--SGWHQLPLGPEAQAACSQGH 160 170 180 190 240 250 260 270 280 290 pF1KB7 SSLDVRIACEQCQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRPFLML .:.. . . : . .:..: ::: .::::. CCDS89 LTLELVL---EGQVAQSSVIL--------------------GGA--------AHRPFV-- 200 210 220 300 310 320 330 340 350 pF1KB7 QARQSEDHPHRRRRRGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECP :: :. .:::..:.: .::...:::.:..:::.:::: : :: :.: :.:: CCDS89 AARVRVGGKHQIHRRGIDCQGGSRMCCRQEFFVDFREIGWHDWIIQPEGYAMNFCIGQCP 230 240 250 260 270 280 360 370 380 390 400 410 pF1KB7 SHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDI :::: : . :::..:.: . . .. :::::: ::.:.:::: .::.: :: CCDS89 LHIAGMPGIAASFHTAVLNLLKANTAAGTTGGGSCCVPTARRPLSLLYYDRDSNIVKTDI 290 300 310 320 330 340 420 pF1KB7 QNMIVEECGCS .:.:: :::: CCDS89 PDMVVEACGCS 350 >>CCDS8939.1 INHBE gene_id:83729|Hs108|chr12 (350 aa) initn: 661 init1: 317 opt: 500 Z-score: 545.5 bits: 109.7 E(32554): 4.6e-24 Smith-Waterman score: 612; 32.0% identity (55.8% similar) in 425 aa overlap (4-426:8-350) 10 20 30 40 50 pF1KB7 MPLLWLRGFLLASCWIIVRSSPTPGSEGHSAAPDCPSCALAALPKDVPNSQPEMV- ::: :: : .::.. : :: ::::. . : .:... .: CCDS89 MRLPDVQLWL--VLL---WALVRAQGT-GSV-------CPSCGGSKL---APQAERALVL 10 20 30 40 60 70 80 90 100 110 pF1KB7 EAVKKHILNMLHLKKRPDVTQPVPKAALLNAIRKLHVGKVGE-NGYVEIEDDIGRRAEMN : .:..::. ::: .:: .:.: :.::: :.:.:. :.:. :: ... : .. CCDS89 ELAKQQILDGLHLTSRPRITHPPPQAALTRALRRLQPGSVAPGNG-----EEVISFATVT 50 60 70 80 90 120 130 140 150 160 170 pF1KB7 ELMEQTSEIITFAESGTARKTLHFEISKEGSDLSVVERAEVWLFLKVPKANRTRTKVTIR . : ..:: : : :. : . .:..:: . .: : . .: CCDS89 DSTSAYSSLLTFHLS-TPRS--HH-----------LYHARLWLHV-LPTLPGT---LCLR 100 110 120 130 140 180 190 200 210 220 230 pF1KB7 LFQQQKHPQGSLDTGEEAEEVGLKGERSELLLSEKVVDARKSTWHVFPVSSSIQRLLDQG .:. : . .. : :. ::.:. . . ::.. . :: : .: CCDS89 IFRW----------GPRRRRQG-----SRTLLAEHHIT--NLGWHTLTLPSSGLRGEKSG 150 160 170 180 240 250 260 270 280 290 pF1KB7 KSSLDVRIACEQCQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRPFLM : ... :. . : : : :. .. . :: ..::: CCDS89 --VLKLQLDCRPLE--GNSTVT-GQPRRLLDT------------AG-------HQQPFLE 190 200 210 220 300 310 320 330 340 350 pF1KB7 LQARQSEDHPHRRRRRGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGEC :. : .: : ::: :. . .::... .:.:...:: :::. : ::. ::: :.: CCDS89 LKIRANEPGAGRARRRTPTCEPATPLCCRRDHYVDFQELGWRDWILQPEGYQLNYCSGQC 230 240 250 260 270 280 360 370 380 390 400 410 pF1KB7 PSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKD : :.::. : . ::::.:.. .....:. :::::: ::.:.:: : . :..: : CCDS89 PPHLAGSPGIAASFHSAVFS--LLKANNPWPASTSCCVPTARRPLSLLYLDHNGNVVKTD 290 300 310 320 330 420 pF1KB7 IQNMIVEECGCS . .:.:: :::: CCDS89 VPDMVVEACGCS 340 350 >>CCDS13099.1 BMP2 gene_id:650|Hs108|chr20 (396 aa) initn: 423 init1: 203 opt: 393 Z-score: 428.7 bits: 88.3 E(32554): 1.5e-17 Smith-Waterman score: 458; 26.8% identity (56.7% similar) in 406 aa overlap (33-425:26-395) 10 20 30 40 50 60 pF1KB7 LLWLRGFLLASCWIIVRSSPTPGSEGHSAAPDCPSCALAALPKDVPNSQP--EMVEAVKK :. .:: . :.::: :.. . CCDS13 MVAGTRCLLALLLPQVLLGGAAGLVPELGRRKFAAASSGRPSSQPSDEVLSEFEL 10 20 30 40 50 70 80 90 100 110 pF1KB7 HILNMLHLKKRPDVTQP--VPKAALLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNELME ..:.:. ::.:: .. :: .:. :. : :. : . . . . ::. . .. CCDS13 RLLSMFGLKQRPTPSRDAVVPPY-MLDLYRR-HSGQPGSPAPDHRLERAASRANTVRSFH 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 QTSEIITFAE-SGTARKTLHFEISKEGSDLSVVERAEVWLF---LKVPKANRTRTKVTIR . . . : :: . . . :..:. .. . ::. .: .. .: . . : CCDS13 HEESLEELPETSGKTTRRFFFNLSSIPTE-EFITSAELQVFREQMQDALGNNSSFHHRIN 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB7 LFQQQKHPQGSLDTGEEAEEVGLKGERSELLLSEKVVDARKSTWHVFPVSSSIQRLLDQG ... : : :.. : ::. ..:. : :. : :. ...: :: CCDS13 IYEIIK-PA----TANSKFPV-------TRLLDTRLVNQNASRWESFDVTPAVMRWTAQG 180 190 200 210 220 240 250 260 270 280 290 pF1KB7 KSSLDVRIACEQCQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRPFLM ... . : : .:..: .:.. . ::.. .. ::.:. CCDS13 HANHGFVVEV-------AHL--------EEKQGVSKRHVRISRSLHQDEHSWSQIRPLLV 230 240 250 260 300 310 320 330 340 350 pF1KB7 LQARQSEDHP-HRRRRRGLECDGKVNI--CCKKQ-FFVSFKDIGWNDWIIAPSGYHANYC ..... :: :.:..: . . . ::.. ..:.:.:.::::::.:: :::: :: CCDS13 TFGHDGKGHPLHKREKRQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYC 270 280 290 300 310 320 360 370 380 390 400 pF1KB7 EGECPSHIAG-TSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQN .:::: .: .... .. .:..: . .. : :.:::::.: .:::: :.... CCDS13 HGECPFPLADHLNSTNHAIVQTLVNS--VNSKIP----KACCVPTELSAISMLYLDENEK 330 340 350 360 370 410 420 pF1KB7 IIKKDIQNMIVEECGCS .. :. :.:.:: ::: CCDS13 VVLKNYQDMVVEGCGCR 380 390 >>CCDS8581.1 GDF3 gene_id:9573|Hs108|chr12 (364 aa) initn: 416 init1: 211 opt: 380 Z-score: 415.2 bits: 85.6 E(32554): 8.4e-17 Smith-Waterman score: 380; 38.5% identity (68.5% similar) in 143 aa overlap (289-425:230-363) 260 270 280 290 300 310 pF1KB7 KKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRPFLMLQARQSEDHPHRRRRRG-----LE : .:.. .. :: :.:: . : CCDS85 LFLEILVKEDRDSGVNFQPEDTCARLRCSLHASLLVVTLNPDQCHPSRKRRAAIPVPKLS 200 210 220 230 240 250 320 330 340 350 360 370 pF1KB7 CDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECP-SHIAGTSGSSLSFHSTV : :.: ..:.:..:.:.::. :::::.:. ::::.:::: : . ..:. .: ... CCDS85 CK---NLCHRHQLFINFRDLGWHKWIIAPKGFMANYCHGECPFSLTISLNSSNYAFMQAL 260 270 280 290 300 310 380 390 400 410 420 pF1KB7 INHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS :.. .: .. :.:::: :.:::: :...:.: . ..:.:.:::: CCDS85 -----MHAVDPEIP-QAVCIPTKLSPISMLYQDNNDNVILRHYEDMVVDECGCG 320 330 340 350 360 >>CCDS34926.1 GDF6 gene_id:392255|Hs108|chr8 (455 aa) initn: 396 init1: 183 opt: 368 Z-score: 400.7 bits: 83.3 E(32554): 5.3e-16 Smith-Waterman score: 371; 29.1% identity (53.1% similar) in 358 aa overlap (103-425:107-454) 80 90 100 110 120 130 pF1KB7 DVTQPVPKAALLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNELMEQTSEIITFAESGTA : . .: : . . .... : .:.. : CCDS34 AQQPRAQEPPGRGPRVVPHEYMLSIYRTYSIAEKLGINASFFQSSKSANTITSFVDRGLD 80 90 100 110 120 130 140 150 160 170 pF1KB7 --------RKTLHFEISKEGSDLSVVERAEVWLFLKVPKA--NRTRTKVTIRLFQ----- :. :..: :: . ::. :: ..:.: . . ..:: CCDS34 DLSHTPLRRQKYLFDVSML-SDKEELVGAELRLFRQAPSAPWGPPAGPLHVQLFPCLSPL 140 150 160 170 180 190 180 190 200 210 220 230 pF1KB7 ----QQKHPQGSLDTGEEAEEV--GLKGER-SELLLSEKVVDARKSTWHVFPVSSSIQRL . :::. .: :. .: ::. . ..: : ... .. .. .. . . :. CCDS34 LLDARTLDPQGAPPAGWEVFDVWQGLRHQPWKQLCLELRAAWGELDAGEAEARARGPQQP 200 210 220 230 240 250 240 250 260 270 280 pF1KB7 LDQGKSSLDVRIACEQCQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQS-H :: . :: : ::.. ....:. .: ... :. .:: : : CCDS34 PPPDLRSLGFGRRVRPPQER-ALLVVFTRSQRKNLFAEMREQLGSAEAAGPGAGAEGSWP 260 270 280 290 300 310 290 300 310 320 330 340 pF1KB7 RPFLMLQARQSEDHPHRRRRR-------GLECDGKVNI-CCKKQFFVSFKDIGWNDWIIA : .:: : ::::: : . : . : :: . :.::..::.::::: CCDS34 PPSGAPDARPWLPSPGRRRRRTAFASRHGKRHGKKSRLRCSKKPLHVNFKELGWDDWIIA 320 330 340 350 360 370 350 360 370 380 390 pF1KB7 PSGYHANYCEGEC--P--SHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLR : :.: .::: : : ::. :. :. . . : . .: .. :::::::: CCDS34 PLEYEAYHCEGVCDFPLRSHLEPTN------HAII--QTLMNSMDPGSTPPSCCVPTKLT 380 390 400 410 420 400 410 420 pF1KB7 PMSMLYYDDGQNIIKKDIQNMIVEECGCS :.:.:: : :.:.. :. ..:.:: ::: CCDS34 PISILYIDAGNNVVYKQYEDMVVESCGCR 430 440 450 >>CCDS437.1 BMP8A gene_id:353500|Hs108|chr1 (402 aa) initn: 359 init1: 191 opt: 361 Z-score: 393.9 bits: 81.9 E(32554): 1.3e-15 Smith-Waterman score: 395; 25.5% identity (53.4% similar) in 436 aa overlap (4-425:8-401) 10 20 30 40 50 pF1KB7 MPLLWLRGFLLASCWIIVRSSPTPGSEGHSAAPDCPSCALAALPKDVPNSQPEMVE ::: :. : : . :. : : ::. :.: . . CCDS43 MAARPGPLWLLGLTL--CAL------GGGGPGLRPPPGCPQRRLGARER----------R 10 20 30 40 60 70 80 90 100 pF1KB7 AVKKHILNMLHLKKRPDVTQP-----VPKAALLNAIRKLHV--GKVGENGYVEIEDDIGR :...:: .: : :: : .: .: : . :. : :.: . :. .:: CCDS43 DVQREILAVLGLPGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDEDG-APAEQRLGR 50 60 70 80 90 100 110 120 130 140 150 160 pF1KB7 RAEMNELMEQTSEIITFAESGTARKTLHFEISKEGSDLSVVERAEVWLFLKVPKANRTRT . ..... . ..... : ..:.... . .:. :: .. :::. . CCDS43 ADLVMSFVNMVERDRALGHQEPHWKEFRFDLTQIPAGEAVTA-AEFRIY-KVPSIHLLNR 110 120 130 140 150 170 180 190 200 210 220 pF1KB7 KVTIRLFQQQKHPQGSLDTGEEAEEVGLKGERSELLLSEKVVDARKSTWHVFPVSSSIQR . . .:: . :.... : . ..:. ... : : :. :... . CCDS43 TLHVSMFQVVQ---------EQSNR-----ESDLFFLDLQTLRAGDEGWLVLDVTAASDC 160 170 180 190 200 230 240 250 260 270 280 pF1KB7 LLDQGKSSLDVRIACEQCQESGASLV--LLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQ : . ...: .:. : :.: :. : : .. ... .. . . . CCDS43 WLLKRHKDLGLRLYVET--EDGHSVDPGLAGLLGQRAPRSQQPFVVTFFRASPSPIRTPR 210 220 230 240 250 260 290 300 310 320 330 340 pF1KB7 SHRPFLMLQARQSEDHPHRRRRRGLECD-----GKVNICCKKQFFVSFKDIGWNDWIIAP . ::. : ..:.. :. : :. : :. ..: .....:::.:.:: ::.::: CCDS43 AVRPLRRRQPKKSNELPQANRLPGIFDDVRGSHGR-QVCRRHELYVSFQDLGWLDWVIAP 270 280 290 300 310 320 350 360 370 380 390 400 pF1KB7 SGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSML .:: : :::::: . : .. . .: . .. .: : :.::.:::: :.: CCDS43 QGYSAYYCEGECSFPL----DSCMNATNHAILQSLVHLMKPNAVPKACCAPTKLSATSVL 330 340 350 360 370 410 420 pF1KB7 YYDDGQNIIKKDIQNMIVEECGCS :::...:.: . .::.:. ::: CCDS43 YYDSSNNVILRKHRNMVVKACGCH 380 390 400 >>CCDS9715.1 BMP4 gene_id:652|Hs108|chr14 (408 aa) initn: 375 init1: 190 opt: 361 Z-score: 393.8 bits: 81.9 E(32554): 1.3e-15 Smith-Waterman score: 390; 25.7% identity (55.0% similar) in 393 aa overlap (53-425:52-407) 30 40 50 60 70 80 pF1KB7 TPGSEGHSAAPDCPSCALAALPKDVPNSQPEMVEAVKKHILNMLHLKKRPDVTQPVPKAA :... . .:.:. :..:: :: .:. CCDS97 SHASLIPETGKKKVAEIQGHAGGRRSGQSHELLRDFEATLLQMFGLRRRP---QPSKSAV 30 40 50 60 70 90 100 110 120 130 140 pF1KB7 LLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNELMEQTSEIITFAESGTARKTLHFEISK . . .: :. . :: : :..: .. : :. . ....:.: ..: : CCDS97 IPDYMRDLYRLQSGE----EEEEQI--HSTGLEYPERPA-----SRANTVR-SFHHEEHL 80 90 100 110 120 150 160 170 180 190 pF1KB7 EGSDLSVVERAEVWLF-LKVPKANRTRTKVTIRLFQQQKHPQGSLDTG----------EE :. . . : .:: :. :.. ... .:::..: . . : . CCDS97 ENIPGTSENSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDWERGFHRINIYEVMKP 130 140 150 160 170 180 200 210 220 230 240 250 pF1KB7 AEEVGLKGERSELLLSEKVVDARKSTWHVFPVSSSIQRLLDQGKSSLDVRIACEQCQESG :: . :. ::. ..: . :..: :: .. : . . . . : . ... CCDS97 PAEV-VPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTR 190 200 210 220 230 240 260 270 280 290 300 310 pF1KB7 ASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRPFLMLQARQSEDHPHRRRRRG . . ... .: : . . ::.:. ..... : ::::. CCDS97 THQGQHVRISRSLPQGSG---------------NWAQLRPLLVTFGHDGRGHALTRRRRA 250 260 270 280 290 320 330 340 350 360 pF1KB7 LECDG-------KVNICCKKQ-FFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAG-TS . : : :... ..:.:.:.::::::.:: ::.: ::.:.:: .: . CCDS97 KRSPKHHSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLN 300 310 320 330 340 350 370 380 390 400 410 420 pF1KB7 GSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEE ... .. .:..: . . : :.:::::.: .:::: :. .... :. :.:.:: CCDS97 STNHAIVQTLVNS--VNSSIP----KACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEG 360 370 380 390 400 pF1KB7 CGCS ::: CCDS97 CGCR >>CCDS444.1 BMP8B gene_id:656|Hs108|chr1 (402 aa) initn: 359 init1: 191 opt: 358 Z-score: 390.7 bits: 81.3 E(32554): 1.9e-15 Smith-Waterman score: 394; 26.3% identity (52.7% similar) in 438 aa overlap (4-425:8-401) 10 20 30 40 50 pF1KB7 MPLLWLRGFLLASCWIIVRSSPTPGSEGHSAAPDCPSCALAALPKDVPNSQPEMVE ::: : :: : . :. : : ::. :.: . . CCDS44 MTALPGPLWLLG--LALCAL------GGGGPGLRPPPGCPQRRLGARER----------R 10 20 30 40 60 70 80 90 100 pF1KB7 AVKKHILNMLHLKKRPDVTQP-----VPKAALLNAIRKLHV--GKVGENGYVEIEDDIGR :...:: .: : :: : .: .: : . :. : :.: . : .:: CCDS44 DVQREILAVLGLPGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDEDG-APAERRLGR 50 60 70 80 90 100 110 120 130 140 150 160 pF1KB7 RAEMNELMEQTSEIITFAESGTARKTLHFEISKEGSDLSVVERAEVWLFLKVPKANRTRT . ..... . ..... : ..:.... . .:. :: .. :::. . CCDS44 ADLVMSFVNMVERDRALGHQEPHWKEFRFDLTQIPAGEAVTA-AEFRIY-KVPSIHLLNR 110 120 130 140 150 170 180 190 200 210 220 pF1KB7 KVTIRLFQQQKHPQGSLDTGEEAEEVGLKGERSELLLSEKVVDARKSTWHVFPVSSSIQR . . .:: . :.... : . ..:. ... : : :. :... . CCDS44 TLHVSMFQVVQ---------EQSNR-----ESDLFFLDLQTLRAGDEGWLVLDVTAASDC 160 170 180 190 200 230 240 250 260 270 280 pF1KB7 LLDQGKSSLDVRIACEQCQESGASLV--LLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQ : . ...: .:. : :.: :. : : .. ... .. . . . CCDS44 WLLKRHKDLGLRLYVET--EDGHSVDPGLAGLLGQRAPRSQQPFVVTFFRASPSPIRTPR 210 220 230 240 250 260 290 300 310 320 330 340 pF1KB7 SHRPFLMLQARQSEDHPHRRRRRGLECD-----GKVNICCKKQFFVSFKDIGWNDWIIAP . ::. : ..:.. :. : :. : :. ..: .....:::.:.:: ::.::: CCDS44 AVRPLRRRQPKKSNELPQANRLPGIFDDVHGSHGR-QVCRRHELYVSFQDLGWLDWVIAP 270 280 290 300 310 320 350 360 370 380 390 400 pF1KB7 SGYHANYCEGEC--PSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMS .:: : :::::: : .. . ..: : : : : : :.::.:::: : CCDS44 QGYSAYYCEGECSFPLDSCMNATNHAILQSLV--HLMM----PDAVPKACCAPTKLSATS 330 340 350 360 370 410 420 pF1KB7 MLYYDDGQNIIKKDIQNMIVEECGCS .::::...:.: . .::.:. ::: CCDS44 VLYYDSSNNVILRKHRNMVVKACGCH 380 390 400 426 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 04:08:58 2016 done: Fri Nov 4 04:08:58 2016 Total Scan time: 3.270 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]