FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7110, 260 aa 1>>>pF1KB7110 260 - 260 aa - 260 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0646+/-0.000403; mu= 17.0642+/- 0.025 mean_var=80.1787+/-17.045, 0's: 0 Z-trim(112.8): 109 B-trim: 1220 in 1/52 Lambda= 0.143234 statistics sampled from 21756 (21870) to 21756 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.629), E-opt: 0.2 (0.256), width: 16 Scan time: 6.720 The best scores are: opt bits E(85289) NP_001002914 (OMIM: 609848) BTB/POZ domain-contain ( 232) 529 118.8 9.1e-27 NP_076981 (OMIM: 615240) BTB/POZ domain-containing ( 234) 350 81.8 1.3e-15 NP_001123466 (OMIM: 615240) BTB/POZ domain-contain ( 283) 350 81.9 1.4e-15 XP_011525599 (OMIM: 615240) PREDICTED: BTB/POZ dom ( 283) 350 81.9 1.4e-15 XP_016882772 (OMIM: 615240) PREDICTED: BTB/POZ dom ( 283) 350 81.9 1.4e-15 XP_011525600 (OMIM: 615240) PREDICTED: BTB/POZ dom ( 283) 350 81.9 1.4e-15 NP_001123467 (OMIM: 615240) BTB/POZ domain-contain ( 283) 350 81.9 1.4e-15 NP_001129677 (OMIM: 181270,613420) BTB/POZ domain- ( 257) 338 79.3 7.5e-15 XP_016881197 (OMIM: 181270,613420) PREDICTED: BTB/ ( 257) 338 79.3 7.5e-15 NP_945342 (OMIM: 181270,613420) BTB/POZ domain-con ( 257) 338 79.3 7.5e-15 NP_001245150 (OMIM: 181270,613420) BTB/POZ domain- ( 257) 338 79.3 7.5e-15 NP_001245151 (OMIM: 181270,613420) BTB/POZ domain- ( 265) 338 79.3 7.6e-15 NP_001136202 (OMIM: 181270,613420) BTB/POZ domain- ( 865) 338 79.8 1.8e-14 XP_011535975 (OMIM: 613423) PREDICTED: BTB/POZ dom ( 286) 298 71.1 2.5e-12 XP_011535974 (OMIM: 613423) PREDICTED: BTB/POZ dom ( 304) 298 71.1 2.6e-12 XP_006714852 (OMIM: 613423) PREDICTED: BTB/POZ dom ( 428) 298 71.3 3.3e-12 XP_005268549 (OMIM: 613423) PREDICTED: BTB/POZ dom ( 428) 298 71.3 3.3e-12 XP_005268550 (OMIM: 613423) PREDICTED: BTB/POZ dom ( 428) 298 71.3 3.3e-12 XP_011535973 (OMIM: 613423) PREDICTED: BTB/POZ dom ( 428) 298 71.3 3.3e-12 NP_065819 (OMIM: 613423) BTB/POZ domain-containing ( 428) 298 71.3 3.3e-12 NP_612453 (OMIM: 610521) BTB/POZ domain-containing ( 325) 284 68.3 2e-11 XP_016878594 (OMIM: 608947) PREDICTED: BTB/POZ dom ( 175) 280 67.2 2.3e-11 NP_849194 (OMIM: 608947) BTB/POZ domain-containing ( 329) 269 65.2 1.8e-10 NP_955751 (OMIM: 607947) potassium channel regulat ( 229) 267 64.6 1.8e-10 NP_775876 (OMIM: 607947) potassium channel regulat ( 272) 267 64.7 2e-10 NP_001304328 (OMIM: 613421) BTB/POZ domain-contain ( 290) 266 64.5 2.5e-10 NP_114160 (OMIM: 613421) BTB/POZ domain-containing ( 313) 266 64.5 2.6e-10 XP_016878595 (OMIM: 608947) PREDICTED: BTB/POZ dom ( 173) 262 63.5 3e-10 NP_001304324 (OMIM: 613421) BTB/POZ domain-contain ( 314) 263 63.9 4e-10 NP_001161433 (OMIM: 611725,611726) BTB/POZ domain- ( 288) 261 63.5 5e-10 NP_694578 (OMIM: 611725,611726) BTB/POZ domain-con ( 289) 261 63.5 5e-10 XP_011544085 (OMIM: 608947) PREDICTED: BTB/POZ dom ( 347) 259 63.1 7.6e-10 NP_066960 (OMIM: 191161) BTB/POZ domain-containing ( 316) 253 61.9 1.7e-09 NP_001306223 (OMIM: 613272) BTB/POZ domain-contain ( 813) 257 63.1 1.9e-09 NP_057205 (OMIM: 613272) BTB/POZ domain-containing ( 815) 257 63.1 1.9e-09 XP_016880482 (OMIM: 191161) PREDICTED: BTB/POZ dom ( 391) 253 61.9 2e-09 XP_011528679 (OMIM: 616386,616398) PREDICTED: BTB/ ( 249) 230 57.0 3.8e-08 XP_011528676 (OMIM: 616386,616398) PREDICTED: BTB/ ( 370) 230 57.2 5.1e-08 NP_001269615 (OMIM: 616386,616398) BTB/POZ domain- ( 220) 212 53.2 4.6e-07 NP_001269614 (OMIM: 616386,616398) BTB/POZ domain- ( 225) 212 53.2 4.7e-07 NP_078957 (OMIM: 616386,616398) BTB/POZ domain-con ( 297) 212 53.4 5.7e-07 XP_005261801 (OMIM: 616386,616398) PREDICTED: BTB/ ( 315) 212 53.4 6e-07 NP_001269613 (OMIM: 616386,616398) BTB/POZ domain- ( 321) 212 53.4 6e-07 XP_005261800 (OMIM: 616386,616398) PREDICTED: BTB/ ( 328) 212 53.4 6.1e-07 XP_005261799 (OMIM: 616386,616398) PREDICTED: BTB/ ( 352) 212 53.4 6.5e-07 XP_005261798 (OMIM: 616386,616398) PREDICTED: BTB/ ( 352) 212 53.4 6.5e-07 NP_061865 (OMIM: 611285) BTB/POZ domain-containing ( 234) 184 47.5 2.7e-05 XP_011522877 (OMIM: 613422) PREDICTED: BTB/POZ dom ( 226) 181 46.8 4e-05 NP_056168 (OMIM: 613422) BTB/POZ domain-containing ( 263) 181 46.9 4.4e-05 XP_011539730 (OMIM: 605411,607346,616399) PREDICTE ( 369) 167 44.1 0.00042 >>NP_001002914 (OMIM: 609848) BTB/POZ domain-containing (232 aa) initn: 457 init1: 246 opt: 529 Z-score: 601.5 bits: 118.8 E(85289): 9.1e-27 Smith-Waterman score: 529; 39.7% identity (68.2% similar) in 239 aa overlap (28-259:1-232) 10 20 30 40 50 pF1KB7 MSDPITLNVGGKLYTTSLATLTSFPDSMLGAMFSG--KMPTKRDSQG--NCFIDRDGKVF :::::: . :: . .::: . :::::::.: NP_001 MLGAMFRAGTPMPPNLNSQGGGHYFIDRDGKAF 10 20 30 60 70 80 90 100 110 pF1KB7 RYILNFLRTSHLDLPEDFQEMGLLRREADFYQVQPLIEALQEKEV-ELSKAEKNAMLNIT :.:::::: ..::::. . : .::: ::::::..::..::.: :. . . : :.:. NP_001 RHILNFLRLGRLDLPRGYGETALLRAEADFYQIRPLLDALRELEASQGTPAPTAALLHAD 40 50 60 70 80 90 120 130 140 150 160 170 pF1KB7 LNQRVQTVHFTVREAPQIYSLSSSSMEVFNANIFSTSCLFLKLLGSKLFYCSNGNLSSIT .. . :::..:..:. : ::: ....: ::.: :. : : .. : ..:. . . NP_001 VDVSPRLVHFSARRGPHHYELSSVQVDTFRANLFCTDSECLGALRAR-FGVASGDRAEGS 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB7 SHLQDPNHLTLDWVANVEGLPEEEYTKQNLKRLWVV-PANK-QINSFQVFVEEVLKIALS :.. :.:. ::: :: . .:. ::. :... .. . :.::::..:: NP_001 PHFH------LEWAPRPVELPEVEYGRLGLQPLWTGGPGERREVVGTPSFLEEVLRVALE 160 170 180 190 200 240 250 260 pF1KB7 DGFCIDSSHPHALDFMNNKIIRLIRYR :: .:: : :..:.. .:..:. NP_001 HGFRLDSVFPDPEDLLNSRSLRFVRH 210 220 230 >>NP_076981 (OMIM: 615240) BTB/POZ domain-containing pro (234 aa) initn: 372 init1: 221 opt: 350 Z-score: 401.6 bits: 81.8 E(85289): 1.3e-15 Smith-Waterman score: 350; 46.7% identity (81.3% similar) in 107 aa overlap (4-109:57-163) 10 20 30 pF1KB7 MSDPITLNVGGKLYTTSLATLTSFPDSMLGAMF :. ..:::..::.::::::..::: .. .: NP_076 MSRLSLTRSPVSPLAAQGIPLPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPDSRISRLF 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB7 SGKMPTKRDS-QGNCFIDRDGKVFRYILNFLRTSHLDLPEDFQEMGLLRREADFYQVQPL .: : :: . . ::::::..:::.:.:::::.: ::.::....:: .:: .::.::. NP_076 NGTEPIVLDSLKQHYFIDRDGEIFRYVLSFLRTSKLLLPDDFKDFSLLYEEARYYQLQPM 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB7 IEALQEKEVELSKAEKNAMLNITLNQRVQTVHFTVREAPQIYSLSSSSMEVFNANIFSTS .. :.. . : . ... NP_076 VRELERWQQEQEQRRRSRACDCLVVRVTPDLGERIALSGEKALIEEVFPETGDVMCNSVN 150 160 170 180 190 200 >>NP_001123466 (OMIM: 615240) BTB/POZ domain-containing (283 aa) initn: 372 init1: 221 opt: 350 Z-score: 400.5 bits: 81.9 E(85289): 1.4e-15 Smith-Waterman score: 350; 46.7% identity (81.3% similar) in 107 aa overlap (4-109:57-163) 10 20 30 pF1KB7 MSDPITLNVGGKLYTTSLATLTSFPDSMLGAMF :. ..:::..::.::::::..::: .. .: NP_001 MSRLSLTRSPVSPLAAQGIPLPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPDSRISRLF 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB7 SGKMPTKRDS-QGNCFIDRDGKVFRYILNFLRTSHLDLPEDFQEMGLLRREADFYQVQPL .: : :: . . ::::::..:::.:.:::::.: ::.::....:: .:: .::.::. NP_001 NGTEPIVLDSLKQHYFIDRDGEIFRYVLSFLRTSKLLLPDDFKDFSLLYEEARYYQLQPM 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB7 IEALQEKEVELSKAEKNAMLNITLNQRVQTVHFTVREAPQIYSLSSSSMEVFNANIFSTS .. :.. . : . ... NP_001 VRELERWQQEQEQRRRSRACDCLVVRVTPDLGERIALSGEKALIEEVFPETGDVMCNSVN 150 160 170 180 190 200 >>XP_011525599 (OMIM: 615240) PREDICTED: BTB/POZ domain- (283 aa) initn: 372 init1: 221 opt: 350 Z-score: 400.5 bits: 81.9 E(85289): 1.4e-15 Smith-Waterman score: 350; 46.7% identity (81.3% similar) in 107 aa overlap (4-109:57-163) 10 20 30 pF1KB7 MSDPITLNVGGKLYTTSLATLTSFPDSMLGAMF :. ..:::..::.::::::..::: .. .: XP_011 MSRLSLTRSPVSPLAAQGIPLPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPDSRISRLF 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB7 SGKMPTKRDS-QGNCFIDRDGKVFRYILNFLRTSHLDLPEDFQEMGLLRREADFYQVQPL .: : :: . . ::::::..:::.:.:::::.: ::.::....:: .:: .::.::. XP_011 NGTEPIVLDSLKQHYFIDRDGEIFRYVLSFLRTSKLLLPDDFKDFSLLYEEARYYQLQPM 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB7 IEALQEKEVELSKAEKNAMLNITLNQRVQTVHFTVREAPQIYSLSSSSMEVFNANIFSTS .. :.. . : . ... XP_011 VRELERWQQEQEQRRRSRACDCLVVRVTPDLGERIALSGEKALIEEVFPETGDVMCNSVN 150 160 170 180 190 200 >>XP_016882772 (OMIM: 615240) PREDICTED: BTB/POZ domain- (283 aa) initn: 372 init1: 221 opt: 350 Z-score: 400.5 bits: 81.9 E(85289): 1.4e-15 Smith-Waterman score: 350; 46.7% identity (81.3% similar) in 107 aa overlap (4-109:57-163) 10 20 30 pF1KB7 MSDPITLNVGGKLYTTSLATLTSFPDSMLGAMF :. ..:::..::.::::::..::: .. .: XP_016 MSRLSLTRSPVSPLAAQGIPLPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPDSRISRLF 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB7 SGKMPTKRDS-QGNCFIDRDGKVFRYILNFLRTSHLDLPEDFQEMGLLRREADFYQVQPL .: : :: . . ::::::..:::.:.:::::.: ::.::....:: .:: .::.::. XP_016 NGTEPIVLDSLKQHYFIDRDGEIFRYVLSFLRTSKLLLPDDFKDFSLLYEEARYYQLQPM 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB7 IEALQEKEVELSKAEKNAMLNITLNQRVQTVHFTVREAPQIYSLSSSSMEVFNANIFSTS .. :.. . : . ... XP_016 VRELERWQQEQEQRRRSRACDCLVVRVTPDLGERIALSGEKALIEEVFPETGDVMCNSVN 150 160 170 180 190 200 >>XP_011525600 (OMIM: 615240) PREDICTED: BTB/POZ domain- (283 aa) initn: 372 init1: 221 opt: 350 Z-score: 400.5 bits: 81.9 E(85289): 1.4e-15 Smith-Waterman score: 350; 46.7% identity (81.3% similar) in 107 aa overlap (4-109:57-163) 10 20 30 pF1KB7 MSDPITLNVGGKLYTTSLATLTSFPDSMLGAMF :. ..:::..::.::::::..::: .. .: XP_011 MSRLSLTRSPVSPLAAQGIPLPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPDSRISRLF 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB7 SGKMPTKRDS-QGNCFIDRDGKVFRYILNFLRTSHLDLPEDFQEMGLLRREADFYQVQPL .: : :: . . ::::::..:::.:.:::::.: ::.::....:: .:: .::.::. XP_011 NGTEPIVLDSLKQHYFIDRDGEIFRYVLSFLRTSKLLLPDDFKDFSLLYEEARYYQLQPM 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB7 IEALQEKEVELSKAEKNAMLNITLNQRVQTVHFTVREAPQIYSLSSSSMEVFNANIFSTS .. :.. . : . ... XP_011 VRELERWQQEQEQRRRSRACDCLVVRVTPDLGERIALSGEKALIEEVFPETGDVMCNSVN 150 160 170 180 190 200 >>NP_001123467 (OMIM: 615240) BTB/POZ domain-containing (283 aa) initn: 372 init1: 221 opt: 350 Z-score: 400.5 bits: 81.9 E(85289): 1.4e-15 Smith-Waterman score: 350; 46.7% identity (81.3% similar) in 107 aa overlap (4-109:57-163) 10 20 30 pF1KB7 MSDPITLNVGGKLYTTSLATLTSFPDSMLGAMF :. ..:::..::.::::::..::: .. .: NP_001 MSRLSLTRSPVSPLAAQGIPLPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPDSRISRLF 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB7 SGKMPTKRDS-QGNCFIDRDGKVFRYILNFLRTSHLDLPEDFQEMGLLRREADFYQVQPL .: : :: . . ::::::..:::.:.:::::.: ::.::....:: .:: .::.::. NP_001 NGTEPIVLDSLKQHYFIDRDGEIFRYVLSFLRTSKLLLPDDFKDFSLLYEEARYYQLQPM 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB7 IEALQEKEVELSKAEKNAMLNITLNQRVQTVHFTVREAPQIYSLSSSSMEVFNANIFSTS .. :.. . : . ... NP_001 VRELERWQQEQEQRRRSRACDCLVVRVTPDLGERIALSGEKALIEEVFPETGDVMCNSVN 150 160 170 180 190 200 >>NP_001129677 (OMIM: 181270,613420) BTB/POZ domain-cont (257 aa) initn: 338 init1: 208 opt: 338 Z-score: 387.6 bits: 79.3 E(85289): 7.5e-15 Smith-Waterman score: 338; 50.5% identity (82.1% similar) in 95 aa overlap (4-97:31-125) 10 20 30 pF1KB7 MSDPITLNVGGKLYTTSLATLTSFPDSMLGAMF :. ..:::..::.::::::..:.: .: .: NP_001 MSRPLITRSPASPLNNQGIPTPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPESRIGRLF 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB7 SGKMPTKRDS-QGNCFIDRDGKVFRYILNFLRTSHLDLPEDFQEMGLLRREADFYQVQPL .: : :: . . ::::::..:::::::::::.: .:.::... :: .:: ..:.::. NP_001 DGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPM 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB7 IEALQEKEVELSKAEKNAMLNITLNQRVQTVHFTVREAPQIYSLSSSSMEVFNANIFSTS . .. NP_001 LLEMERWKQDRETGRFSRPCECLVVRVAPDLGERITLSGDKSLIEEVFPEIGDVMCNSVN 130 140 150 160 170 180 >>XP_016881197 (OMIM: 181270,613420) PREDICTED: BTB/POZ (257 aa) initn: 338 init1: 208 opt: 338 Z-score: 387.6 bits: 79.3 E(85289): 7.5e-15 Smith-Waterman score: 338; 50.5% identity (82.1% similar) in 95 aa overlap (4-97:31-125) 10 20 30 pF1KB7 MSDPITLNVGGKLYTTSLATLTSFPDSMLGAMF :. ..:::..::.::::::..:.: .: .: XP_016 MSRPLITRSPASPLNNQGIPTPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPESRIGRLF 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB7 SGKMPTKRDS-QGNCFIDRDGKVFRYILNFLRTSHLDLPEDFQEMGLLRREADFYQVQPL .: : :: . . ::::::..:::::::::::.: .:.::... :: .:: ..:.::. XP_016 DGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPM 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB7 IEALQEKEVELSKAEKNAMLNITLNQRVQTVHFTVREAPQIYSLSSSSMEVFNANIFSTS . .. XP_016 LLEMERWKQDRETGRFSRPCECLVVRVAPDLGERITLSGDKSLIEEVFPEIGDVMCNSVN 130 140 150 160 170 180 >>NP_945342 (OMIM: 181270,613420) BTB/POZ domain-contain (257 aa) initn: 338 init1: 208 opt: 338 Z-score: 387.6 bits: 79.3 E(85289): 7.5e-15 Smith-Waterman score: 338; 50.5% identity (82.1% similar) in 95 aa overlap (4-97:31-125) 10 20 30 pF1KB7 MSDPITLNVGGKLYTTSLATLTSFPDSMLGAMF :. ..:::..::.::::::..:.: .: .: NP_945 MSRPLITRSPASPLNNQGIPTPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPESRIGRLF 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB7 SGKMPTKRDS-QGNCFIDRDGKVFRYILNFLRTSHLDLPEDFQEMGLLRREADFYQVQPL .: : :: . . ::::::..:::::::::::.: .:.::... :: .:: ..:.::. NP_945 DGTEPIVLDSLKQHYFIDRDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPM 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB7 IEALQEKEVELSKAEKNAMLNITLNQRVQTVHFTVREAPQIYSLSSSSMEVFNANIFSTS . .. NP_945 LLEMERWKQDRETGRFSRPCECLVVRVAPDLGERITLSGDKSLIEEVFPEIGDVMCNSVN 130 140 150 160 170 180 260 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 04:45:36 2016 done: Fri Nov 4 04:45:37 2016 Total Scan time: 6.720 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]