FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7147, 346 aa 1>>>pF1KB7147 346 - 346 aa - 346 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.5681+/-0.000383; mu= 21.0162+/- 0.024 mean_var=104.8102+/-27.333, 0's: 0 Z-trim(113.3): 486 B-trim: 2338 in 2/48 Lambda= 0.125277 statistics sampled from 21962 (22621) to 21962 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.627), E-opt: 0.2 (0.265), width: 16 Scan time: 8.290 The best scores are: opt bits E(85289) NP_005295 (OMIM: 603821) free fatty acid receptor ( 346) 2341 434.1 2.2e-121 XP_011525160 (OMIM: 603821) PREDICTED: free fatty ( 383) 2341 434.2 2.3e-121 NP_005297 (OMIM: 603823) free fatty acid receptor ( 330) 851 164.8 2.4e-40 XP_016882198 (OMIM: 603823) PREDICTED: free fatty ( 330) 851 164.8 2.4e-40 XP_016882199 (OMIM: 603823) PREDICTED: free fatty ( 330) 851 164.8 2.4e-40 XP_016882200 (OMIM: 603823) PREDICTED: free fatty ( 330) 851 164.8 2.4e-40 NP_001983 (OMIM: 187930) proteinase-activated rece ( 425) 460 94.3 5.3e-19 NP_005294 (OMIM: 603820) free fatty acid receptor ( 300) 452 92.6 1.2e-18 XP_016864712 (OMIM: 600933) PREDICTED: proteinase- ( 383) 441 90.8 5.4e-18 NP_005233 (OMIM: 600933) proteinase-activated rece ( 397) 441 90.8 5.5e-18 NP_001136433 (OMIM: 606926) lysophosphatidic acid ( 372) 416 86.2 1.2e-16 NP_065133 (OMIM: 606926) lysophosphatidic acid rec ( 372) 416 86.2 1.2e-16 NP_001154889 (OMIM: 603071) uracil nucleotide/cyst ( 339) 404 84.0 5.2e-16 NP_001154888 (OMIM: 603071) uracil nucleotide/cyst ( 339) 404 84.0 5.2e-16 NP_005282 (OMIM: 603071) uracil nucleotide/cystein ( 367) 404 84.0 5.4e-16 XP_016859322 (OMIM: 603071) PREDICTED: uracil nucl ( 367) 404 84.0 5.4e-16 NP_001154887 (OMIM: 603071) uracil nucleotide/cyst ( 367) 404 84.0 5.4e-16 NP_003941 (OMIM: 602779) proteinase-activated rece ( 385) 401 83.5 8.1e-16 NP_001243495 (OMIM: 601919) proteinase-activated r ( 352) 400 83.3 8.7e-16 NP_004092 (OMIM: 601919) proteinase-activated rece ( 374) 400 83.3 9.1e-16 NP_001298242 (OMIM: 187930) proteinase-activated r ( 304) 388 81.0 3.6e-15 XP_005274835 (OMIM: 300525) PREDICTED: P2Y purinoc ( 359) 374 78.6 2.3e-14 XP_011544480 (OMIM: 300525) PREDICTED: P2Y purinoc ( 359) 374 78.6 2.3e-14 XP_011543933 (OMIM: 300525) PREDICTED: P2Y purinoc ( 359) 374 78.6 2.3e-14 XP_005274486 (OMIM: 300525) PREDICTED: P2Y purinoc ( 359) 374 78.6 2.3e-14 NP_835230 (OMIM: 300525) P2Y purinoceptor 8 [Homo ( 359) 374 78.6 2.3e-14 XP_011544481 (OMIM: 300525) PREDICTED: P2Y purinoc ( 359) 374 78.6 2.3e-14 XP_011543934 (OMIM: 300525) PREDICTED: P2Y purinoc ( 359) 374 78.6 2.3e-14 NP_001248381 (OMIM: 600239) G-protein coupled rece ( 355) 373 78.4 2.6e-14 NP_001091669 (OMIM: 600239) G-protein coupled rece ( 355) 373 78.4 2.6e-14 NP_001248383 (OMIM: 600239) G-protein coupled rece ( 355) 373 78.4 2.6e-14 XP_016859321 (OMIM: 600239) PREDICTED: G-protein c ( 355) 373 78.4 2.6e-14 NP_001248384 (OMIM: 600239) G-protein coupled rece ( 355) 373 78.4 2.6e-14 NP_005270 (OMIM: 600239) G-protein coupled recepto ( 355) 373 78.4 2.6e-14 XP_005246528 (OMIM: 600239) PREDICTED: G-protein c ( 355) 373 78.4 2.6e-14 NP_001248382 (OMIM: 600239) G-protein coupled rece ( 355) 373 78.4 2.6e-14 XP_006724927 (OMIM: 300525) PREDICTED: P2Y purinoc ( 548) 374 78.9 2.9e-14 XP_006724506 (OMIM: 300525) PREDICTED: P2Y purinoc ( 548) 374 78.9 2.9e-14 NP_001295399 (OMIM: 605666) cysteinyl leukotriene ( 346) 371 78.0 3.3e-14 NP_001295400 (OMIM: 605666) cysteinyl leukotriene ( 346) 371 78.0 3.3e-14 NP_001295398 (OMIM: 605666) cysteinyl leukotriene ( 346) 371 78.0 3.3e-14 NP_065110 (OMIM: 605666) cysteinyl leukotriene rec ( 346) 371 78.0 3.3e-14 NP_001295394 (OMIM: 605666) cysteinyl leukotriene ( 346) 371 78.0 3.3e-14 NP_001295397 (OMIM: 605666) cysteinyl leukotriene ( 346) 371 78.0 3.3e-14 NP_001295396 (OMIM: 605666) cysteinyl leukotriene ( 346) 371 78.0 3.3e-14 NP_001295405 (OMIM: 605666) cysteinyl leukotriene ( 346) 371 78.0 3.3e-14 NP_001044 (OMIM: 182455) somatostatin receptor typ ( 364) 366 77.2 6.3e-14 NP_001166031 (OMIM: 182455) somatostatin receptor ( 364) 366 77.2 6.3e-14 NP_002556 (OMIM: 300038) P2Y purinoceptor 4 [Homo ( 365) 365 77.0 7.2e-14 NP_001043 (OMIM: 182454) somatostatin receptor typ ( 388) 365 77.0 7.4e-14 >>NP_005295 (OMIM: 603821) free fatty acid receptor 3 [H (346 aa) initn: 2341 init1: 2341 opt: 2341 Z-score: 2300.4 bits: 434.1 E(85289): 2.2e-121 Smith-Waterman score: 2341; 99.7% identity (100.0% similar) in 346 aa overlap (1-346:1-346) 10 20 30 40 50 60 pF1KB7 MDTGPDQSYFSGNHWFVFSVYLLTFLVGLPLNLLALVVFVGKLQRRPVAVDVLLLNLTAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MDTGPDQSYFSGNHWFVFSVYLLTFLVGLPLNLLALVVFVGKLQRRPVAVDVLLLNLTAS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 DLLLLLFLPFRMVEAANGMHWPLPFILCPLSGFIFFTTIYLTALFLAAVSIERFLSVAHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 DLLLLLFLPFRMVEAANGMHWPLPFILCPLSGFIFFTTIYLTALFLAAVSIERFLSVAHP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 LWYKTRPRLGQAGLVSVACWLLASAHCSVVYVIEFSGDISHSQGTNGTCYLEFRKDQLAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LWYKTRPRLGQAGLVSVACWLLASAHCSVVYVIEFSGDISHSQGTNGTCYLEFRKDQLAI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 LLPVRLEMAVVLFVVPLIITSYCYSRLVWILGRGGSHRRQRRVAGLLAATLLNFLVCFGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LLPVRLEMAVVLFVVPLIITSYCYSRLVWILGRGGSHRRQRRVAGLLAATLLNFLVCFGP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 YNASHVVGYICGESPAWRIYVTLLSTLNSCVDPFVYYFSSSGFQADFHELLRRLCGLWGQ ::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 YNVSHVVGYICGESPAWRIYVTLLSTLNSCVDPFVYYFSSSGFQADFHELLRRLCGLWGQ 250 260 270 280 290 300 310 320 330 340 pF1KB7 WQQESSMELKEQKGGEEQRADRPAERKTSEHSQGCGTGGQVACAES :::::::::::::::::::::::::::::::::::::::::::::: NP_005 WQQESSMELKEQKGGEEQRADRPAERKTSEHSQGCGTGGQVACAES 310 320 330 340 >>XP_011525160 (OMIM: 603821) PREDICTED: free fatty acid (383 aa) initn: 2341 init1: 2341 opt: 2341 Z-score: 2299.9 bits: 434.2 E(85289): 2.3e-121 Smith-Waterman score: 2341; 99.7% identity (100.0% similar) in 346 aa overlap (1-346:38-383) 10 20 30 pF1KB7 MDTGPDQSYFSGNHWFVFSVYLLTFLVGLP :::::::::::::::::::::::::::::: XP_011 CGICSPFSMLTSPGNGAQGIYVPLLNMATTMDTGPDQSYFSGNHWFVFSVYLLTFLVGLP 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB7 LNLLALVVFVGKLQRRPVAVDVLLLNLTASDLLLLLFLPFRMVEAANGMHWPLPFILCPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LNLLALVVFVGKLQRRPVAVDVLLLNLTASDLLLLLFLPFRMVEAANGMHWPLPFILCPL 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB7 SGFIFFTTIYLTALFLAAVSIERFLSVAHPLWYKTRPRLGQAGLVSVACWLLASAHCSVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGFIFFTTIYLTALFLAAVSIERFLSVAHPLWYKTRPRLGQAGLVSVACWLLASAHCSVV 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB7 YVIEFSGDISHSQGTNGTCYLEFRKDQLAILLPVRLEMAVVLFVVPLIITSYCYSRLVWI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YVIEFSGDISHSQGTNGTCYLEFRKDQLAILLPVRLEMAVVLFVVPLIITSYCYSRLVWI 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB7 LGRGGSHRRQRRVAGLLAATLLNFLVCFGPYNASHVVGYICGESPAWRIYVTLLSTLNSC ::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::: XP_011 LGRGGSHRRQRRVAGLLAATLLNFLVCFGPYNVSHVVGYICGESPAWRIYVTLLSTLNSC 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB7 VDPFVYYFSSSGFQADFHELLRRLCGLWGQWQQESSMELKEQKGGEEQRADRPAERKTSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VDPFVYYFSSSGFQADFHELLRRLCGLWGQWQQESSMELKEQKGGEEQRADRPAERKTSE 310 320 330 340 350 360 340 pF1KB7 HSQGCGTGGQVACAES :::::::::::::::: XP_011 HSQGCGTGGQVACAES 370 380 >>NP_005297 (OMIM: 603823) free fatty acid receptor 2 [H (330 aa) initn: 824 init1: 322 opt: 851 Z-score: 845.2 bits: 164.8 E(85289): 2.4e-40 Smith-Waterman score: 851; 42.2% identity (75.3% similar) in 308 aa overlap (16-314:9-315) 10 20 30 40 50 pF1KB7 MDTGPDQSYFSGNHWFVFSVYLLTFLVGLPLNLLALVVFVGKL-QRRPVAVDVLLLNLTA ... .:.. ::.::: ::::: .:::.. : .:. : .:::.:: NP_005 MLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTL 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 SDLLLLLFLPFRMVEAANGMHWPLPFILCPLSGFIFFTTIYLTALFLAAVSIERFLSVAH .::::::.:::...:::....: :: ..: :..: :...:: .. .::..::::.:.:: NP_005 ADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAF 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 PLWYKTRPRLGQAGLVSVACWLLASAHCSVVYVIEFSGDISHSQ-GTNGTCYLEFRKDQL :. :: : . ..... :... .::..: .... . . . :.. ::: .: .:: NP_005 PVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQL 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB7 AILLPVRLEMAVVLFVVPLIITSYCYSRLVWILGRG---GSHRRQRRVAGLLAATLLNFL ..::::::. .::: .:. .: .:: :.:::. :..:: ::..:: ..:::::: NP_005 DVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRR-RRAVGLAVVTLLNFL 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 VCFGPYNASHVVGYICGESPAWRIYVTLLSTLNSCVDPFVYYFSSSGFQADFHELLRRL- :::::::.::.::: .:: :: ....:.::. .::...::::: . : . :. : NP_005 VCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLR 240 250 260 270 280 290 300 310 320 330 340 pF1KB7 ---CGLWGQWQQESSMELKEQKGGEEQRADRPAERKTSEHSQGCGTGGQVACAES .: :. .... .:..: NP_005 NQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE 300 310 320 330 >>XP_016882198 (OMIM: 603823) PREDICTED: free fatty acid (330 aa) initn: 824 init1: 322 opt: 851 Z-score: 845.2 bits: 164.8 E(85289): 2.4e-40 Smith-Waterman score: 851; 42.2% identity (75.3% similar) in 308 aa overlap (16-314:9-315) 10 20 30 40 50 pF1KB7 MDTGPDQSYFSGNHWFVFSVYLLTFLVGLPLNLLALVVFVGKL-QRRPVAVDVLLLNLTA ... .:.. ::.::: ::::: .:::.. : .:. : .:::.:: XP_016 MLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTL 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 SDLLLLLFLPFRMVEAANGMHWPLPFILCPLSGFIFFTTIYLTALFLAAVSIERFLSVAH .::::::.:::...:::....: :: ..: :..: :...:: .. .::..::::.:.:: XP_016 ADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAF 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 PLWYKTRPRLGQAGLVSVACWLLASAHCSVVYVIEFSGDISHSQ-GTNGTCYLEFRKDQL :. :: : . ..... :... .::..: .... . . . :.. ::: .: .:: XP_016 PVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQL 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB7 AILLPVRLEMAVVLFVVPLIITSYCYSRLVWILGRG---GSHRRQRRVAGLLAATLLNFL ..::::::. .::: .:. .: .:: :.:::. :..:: ::..:: ..:::::: XP_016 DVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRR-RRAVGLAVVTLLNFL 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 VCFGPYNASHVVGYICGESPAWRIYVTLLSTLNSCVDPFVYYFSSSGFQADFHELLRRL- :::::::.::.::: .:: :: ....:.::. .::...::::: . : . :. : XP_016 VCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLR 240 250 260 270 280 290 300 310 320 330 340 pF1KB7 ---CGLWGQWQQESSMELKEQKGGEEQRADRPAERKTSEHSQGCGTGGQVACAES .: :. .... .:..: XP_016 NQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE 300 310 320 330 >>XP_016882199 (OMIM: 603823) PREDICTED: free fatty acid (330 aa) initn: 824 init1: 322 opt: 851 Z-score: 845.2 bits: 164.8 E(85289): 2.4e-40 Smith-Waterman score: 851; 42.2% identity (75.3% similar) in 308 aa overlap (16-314:9-315) 10 20 30 40 50 pF1KB7 MDTGPDQSYFSGNHWFVFSVYLLTFLVGLPLNLLALVVFVGKL-QRRPVAVDVLLLNLTA ... .:.. ::.::: ::::: .:::.. : .:. : .:::.:: XP_016 MLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTL 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 SDLLLLLFLPFRMVEAANGMHWPLPFILCPLSGFIFFTTIYLTALFLAAVSIERFLSVAH .::::::.:::...:::....: :: ..: :..: :...:: .. .::..::::.:.:: XP_016 ADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAF 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 PLWYKTRPRLGQAGLVSVACWLLASAHCSVVYVIEFSGDISHSQ-GTNGTCYLEFRKDQL :. :: : . ..... :... .::..: .... . . . :.. ::: .: .:: XP_016 PVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQL 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB7 AILLPVRLEMAVVLFVVPLIITSYCYSRLVWILGRG---GSHRRQRRVAGLLAATLLNFL ..::::::. .::: .:. .: .:: :.:::. :..:: ::..:: ..:::::: XP_016 DVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRR-RRAVGLAVVTLLNFL 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 VCFGPYNASHVVGYICGESPAWRIYVTLLSTLNSCVDPFVYYFSSSGFQADFHELLRRL- :::::::.::.::: .:: :: ....:.::. .::...::::: . : . :. : XP_016 VCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLR 240 250 260 270 280 290 300 310 320 330 340 pF1KB7 ---CGLWGQWQQESSMELKEQKGGEEQRADRPAERKTSEHSQGCGTGGQVACAES .: :. .... .:..: XP_016 NQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE 300 310 320 330 >>XP_016882200 (OMIM: 603823) PREDICTED: free fatty acid (330 aa) initn: 824 init1: 322 opt: 851 Z-score: 845.2 bits: 164.8 E(85289): 2.4e-40 Smith-Waterman score: 851; 42.2% identity (75.3% similar) in 308 aa overlap (16-314:9-315) 10 20 30 40 50 pF1KB7 MDTGPDQSYFSGNHWFVFSVYLLTFLVGLPLNLLALVVFVGKL-QRRPVAVDVLLLNLTA ... .:.. ::.::: ::::: .:::.. : .:. : .:::.:: XP_016 MLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTL 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 SDLLLLLFLPFRMVEAANGMHWPLPFILCPLSGFIFFTTIYLTALFLAAVSIERFLSVAH .::::::.:::...:::....: :: ..: :..: :...:: .. .::..::::.:.:: XP_016 ADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAF 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 PLWYKTRPRLGQAGLVSVACWLLASAHCSVVYVIEFSGDISHSQ-GTNGTCYLEFRKDQL :. :: : . ..... :... .::..: .... . . . :.. ::: .: .:: XP_016 PVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQL 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB7 AILLPVRLEMAVVLFVVPLIITSYCYSRLVWILGRG---GSHRRQRRVAGLLAATLLNFL ..::::::. .::: .:. .: .:: :.:::. :..:: ::..:: ..:::::: XP_016 DVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRR-RRAVGLAVVTLLNFL 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 VCFGPYNASHVVGYICGESPAWRIYVTLLSTLNSCVDPFVYYFSSSGFQADFHELLRRL- :::::::.::.::: .:: :: ....:.::. .::...::::: . : . :. : XP_016 VCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLR 240 250 260 270 280 290 300 310 320 330 340 pF1KB7 ---CGLWGQWQQESSMELKEQKGGEEQRADRPAERKTSEHSQGCGTGGQVACAES .: :. .... .:..: XP_016 NQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE 300 310 320 330 >>NP_001983 (OMIM: 187930) proteinase-activated receptor (425 aa) initn: 326 init1: 193 opt: 460 Z-score: 462.1 bits: 94.3 E(85289): 5.3e-19 Smith-Waterman score: 460; 30.3% identity (60.3% similar) in 300 aa overlap (6-291:91-386) 10 20 30 pF1KB7 MDTGPDQSYFSGNHW---FVFSVYLLTFLVGLPLN : : . . : :: ::: .:.:.:::: NP_001 KNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLN 70 80 90 100 110 120 40 50 60 70 80 90 pF1KB7 LLALVVFVGKLQRRPVAVDVLLLNLTASDLLLLLFLPFRMVEAANGMHWPLPFILCPLSG ..:.:::. :.. . :: : .:.:...:.:.. :::.. .: : . :: . NP_001 IMAIVVFILKMKVKKPAV-VYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVT 130 140 150 160 170 100 110 120 130 140 150 pF1KB7 FIFFTTIYLTALFLAAVSIERFLSVAHPLWYKTRPRLGQAGLVSVACWLLASAHCSVVYV :. ..: . :.....::.:::.:..:. . ::.:... .: : :: : . . NP_001 AAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLL 180 190 200 210 220 230 160 170 180 190 200 210 pF1KB7 IEFSGDISHSQGTN-GTCYLEFRKDQLAILLPVRLE-MAVVLFVVPLIITSYCYSRLVWI : . .. : : ::. . . : . ...:.: :::::.. :: .. NP_001 KEQTIQVP---GLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRC 240 250 260 270 280 290 220 230 240 250 260 pF1KB7 LGRGGSHRRQRRVAGLL--AATLLNFLVCFGPYNASHVVGY--ICGESPAWRIYVTLL-- :. .. :... .:. ::.. :..:::: :. .. : . : . : . : NP_001 LSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLC 300 310 320 330 340 350 270 280 290 300 310 320 pF1KB7 ---STLNSCVDPFVYYFSSSGFQADFHELLRRLCGLWGQWQQESSMELKEQKGGEEQRAD :... :.::..::..:: : . .: NP_001 VCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLN 360 370 380 390 400 410 >>NP_005294 (OMIM: 603820) free fatty acid receptor 1 [H (300 aa) initn: 388 init1: 215 opt: 452 Z-score: 455.9 bits: 92.6 E(85289): 1.2e-18 Smith-Waterman score: 466; 33.8% identity (62.2% similar) in 275 aa overlap (18-282:9-282) 10 20 30 40 50 60 pF1KB7 MDTGPDQSYFSGNHWFVFSVYLLTFLVGLPLNLLALVVFVGKLQRRPVAVDVLLLNLTAS :..:. .: .:.:::.::. ... . : . : ::: : NP_005 MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCS 10 20 30 40 50 70 80 90 100 110 120 pF1KB7 DLLLLLFLPFRMVEAANGMHWPLPFILCPLSGFIFFTTIYLTALFLAAVSIERFLSVAHP :::: . ::.. ::: . :::: :::. . : .: . ::::.: :.:..: : NP_005 DLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFP 60 70 80 90 100 110 130 140 150 160 170 pF1KB7 LWYKTRPRLGQAGLVSVACWLLASAHCSVVYVIEFSGD-ISHSQGT-------NGTCYLE : :.. : . : .: : :. : ..:. .: : ..::. . ::. NP_005 LGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCL 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB7 FRKDQLAILLPVRLEMAVVLFVVPLIITSYCYSRLVWILGRGG-SHRRQRRVAGLLAATL : : :.:. ....:: .:: ::..:: . :.:.: .:::. :.: . ...: NP_005 EAWDP-ASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGAL 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 LNFLVCFGPYNASHVVGYICGE-SPAWRIYVTLLSTLNSCVDPFVYYFSSSGFQADFHEL :..:.: ::::::.:.... . . .:: . .. . ..:.: . . : NP_005 LTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCA 240 250 260 270 280 290 300 310 320 330 340 pF1KB7 LRRLCGLWGQWQQESSMELKEQKGGEEQRADRPAERKTSEHSQGCGTGGQVACAES NP_005 ARTQGGKSQK 300 >>XP_016864712 (OMIM: 600933) PREDICTED: proteinase-acti (383 aa) initn: 357 init1: 133 opt: 441 Z-score: 444.0 bits: 90.8 E(85289): 5.4e-18 Smith-Waterman score: 441; 31.0% identity (61.4% similar) in 303 aa overlap (8-295:53-347) 10 20 30 pF1KB7 MDTGPDQSYFSGNHWFVFS--VYLLTFLVGLPLNLLA : ..:. :: :: ..:.:::: : .: XP_016 SLIGKVDGTSHVTGKGVTVETVFSVDEFSASVLTGKLTTVFLPIVYTIVFVVGLPSNGMA 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB7 LVVFVGKLQRRPVAVDVLLLNLTASDLLLLLFLPFRMVEAANGMHWPLPFILCP-LSGFI : ::. . ... :: . . ::. .::: ....:.... .: .: :: : :: XP_016 LWVFLFRTKKKHPAV-IYMANLALADLLSVIWFPLKIAYHIHGNNWIYGEALCNVLIGF- 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB7 FFTTIYLTALFLAAVSIERFLSVAHPLWYKTRPRLGQAGLVSVACWLLASAHCSVVYVIE :. ..: . ::.. .:..:. ...:. . .: . . : .:.: ::: .::.. XP_016 FYGNMYCSILFMTCLSVQRYWVIVNPMGH-SRKKANIAIGISLAIWLLILLVTIPLYVVK 150 160 170 180 190 160 170 180 190 200 210 pF1KB7 FSGDISHSQGTNGTCYLEFRKDQLAI--LLPVRLEMAVVLFVVPLIITSYCYSRLVWILG . : . : ::. . .:: . .. : .:. .:. : ..:. : .. .: XP_016 QTIFIPALNIT--TCH-DVLPEQLLVGDMFNYFLSLAIGVFLFPAFLTASAYVLMIRMLR 200 210 220 230 240 250 220 230 240 250 260 pF1KB7 RGG----SHRRQRRVAGLLAATLLNFLVCFGPYNASHVVGYIC----GESPAWRIYVTLL .. :.....:. :....: .:.:: : : :: :. :.: .. .:.. : XP_016 SSAMDENSEKKRKRAIKLIVTVLAMYLICFTPSNLLLVVHYFLIKSQGQSHVYALYIVAL 260 270 280 290 300 310 270 280 290 300 310 320 pF1KB7 --STLNSCVDPFVYYFSSSGFQADFHELLRRLCGLWGQWQQESSMELKEQKGGEEQRADR ::::::.::::::: : :. .. : :: XP_016 CLSTLNSCIDPFVYYFVSHDFRDHAKNAL--LCRSVRTVKQMQVSLTSKKHSRKSSSYSS 320 330 340 350 360 370 330 340 pF1KB7 PAERKTSEHSQGCGTGGQVACAES XP_016 SSTTVKTSY 380 >>NP_005233 (OMIM: 600933) proteinase-activated receptor (397 aa) initn: 355 init1: 133 opt: 441 Z-score: 443.9 bits: 90.8 E(85289): 5.5e-18 Smith-Waterman score: 441; 31.0% identity (61.4% similar) in 303 aa overlap (8-295:67-361) 10 20 30 pF1KB7 MDTGPDQSYFSGNHWFVFS--VYLLTFLVGLPLNLLA : ..:. :: :: ..:.:::: : .: NP_005 SLIGKVDGTSHVTGKGVTVETVFSVDEFSASVLTGKLTTVFLPIVYTIVFVVGLPSNGMA 40 50 60 70 80 90 40 50 60 70 80 90 pF1KB7 LVVFVGKLQRRPVAVDVLLLNLTASDLLLLLFLPFRMVEAANGMHWPLPFILCP-LSGFI : ::. . ... :: . . ::. .::: ....:.... .: .: :: : :: NP_005 LWVFLFRTKKKHPAV-IYMANLALADLLSVIWFPLKIAYHIHGNNWIYGEALCNVLIGF- 100 110 120 130 140 150 100 110 120 130 140 150 pF1KB7 FFTTIYLTALFLAAVSIERFLSVAHPLWYKTRPRLGQAGLVSVACWLLASAHCSVVYVIE :. ..: . ::.. .:..:. ...:. . .: . . : .:.: ::: .::.. NP_005 FYGNMYCSILFMTCLSVQRYWVIVNPMGH-SRKKANIAIGISLAIWLLILLVTIPLYVVK 160 170 180 190 200 210 160 170 180 190 200 210 pF1KB7 FSGDISHSQGTNGTCYLEFRKDQLAI--LLPVRLEMAVVLFVVPLIITSYCYSRLVWILG . : . : ::. . .:: . .. : .:. .:. : ..:. : .. .: NP_005 QTIFIPALNIT--TCH-DVLPEQLLVGDMFNYFLSLAIGVFLFPAFLTASAYVLMIRMLR 220 230 240 250 260 270 220 230 240 250 260 pF1KB7 RGG----SHRRQRRVAGLLAATLLNFLVCFGPYNASHVVGYIC----GESPAWRIYVTLL .. :.....:. :....: .:.:: : : :: :. :.: .. .:.. : NP_005 SSAMDENSEKKRKRAIKLIVTVLAMYLICFTPSNLLLVVHYFLIKSQGQSHVYALYIVAL 280 290 300 310 320 330 270 280 290 300 310 320 pF1KB7 --STLNSCVDPFVYYFSSSGFQADFHELLRRLCGLWGQWQQESSMELKEQKGGEEQRADR ::::::.::::::: : :. .. : :: NP_005 CLSTLNSCIDPFVYYFVSHDFRDHAKNAL--LCRSVRTVKQMQVSLTSKKHSRKSSSYSS 340 350 360 370 380 330 340 pF1KB7 PAERKTSEHSQGCGTGGQVACAES NP_005 SSTTVKTSY 390 346 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 05:17:02 2016 done: Fri Nov 4 05:17:03 2016 Total Scan time: 8.290 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]