FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7169, 433 aa 1>>>pF1KB7169 433 - 433 aa - 433 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.7772+/-0.000364; mu= 6.1555+/- 0.023 mean_var=145.5854+/-29.009, 0's: 0 Z-trim(117.8): 48 B-trim: 306 in 1/52 Lambda= 0.106296 statistics sampled from 30110 (30160) to 30110 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.711), E-opt: 0.2 (0.354), width: 16 Scan time: 10.120 The best scores are: opt bits E(85289) XP_011507718 (OMIM: 116200,600897,612474) PREDICTE ( 433) 2876 452.7 8.4e-127 NP_005258 (OMIM: 116200,600897,612474) gap junctio ( 433) 2876 452.7 8.4e-127 XP_011507719 (OMIM: 116200,600897,612474) PREDICTE ( 427) 2840 447.2 3.8e-125 XP_011533350 (OMIM: 121015,601885) PREDICTED: gap ( 435) 1175 191.9 2.8e-48 NP_068773 (OMIM: 121015,601885) gap junction alpha ( 435) 1175 191.9 2.8e-48 XP_016856533 (OMIM: 108770,121013,612474,614049) P ( 358) 1032 169.9 9.6e-42 NP_005257 (OMIM: 108770,121013,612474,614049) gap ( 358) 1032 169.9 9.6e-42 XP_005273008 (OMIM: 108770,121013,612474,614049) P ( 358) 1032 169.9 9.6e-42 NP_859054 (OMIM: 108770,121013,612474,614049) gap ( 358) 1032 169.9 9.6e-42 NP_115991 (OMIM: 611924) gap junction alpha-10 pro ( 543) 955 158.2 4.9e-38 NP_110399 (OMIM: 611923) gap junction alpha-9 prot ( 515) 945 156.6 1.3e-37 NP_000156 (OMIM: 104100,121014,133200,164200,18610 ( 382) 900 149.7 1.3e-35 XP_016856532 (OMIM: 121012) PREDICTED: gap junctio ( 333) 881 146.7 8.5e-35 NP_002051 (OMIM: 121012) gap junction alpha-4 prot ( 333) 881 146.7 8.5e-35 XP_005270807 (OMIM: 121012) PREDICTED: gap junctio ( 333) 881 146.7 8.5e-35 NP_003995 (OMIM: 121011,124500,148210,148350,14920 ( 226) 501 88.3 2.1e-17 XP_011533351 (OMIM: 121011,124500,148210,148350,14 ( 226) 501 88.3 2.1e-17 NP_699199 (OMIM: 611922) gap junction delta-4 prot ( 370) 495 87.5 6.1e-17 NP_001103689 (OMIM: 129500,220290,304400,604418,61 ( 261) 488 86.4 9.6e-17 XP_016875846 (OMIM: 129500,220290,304400,604418,61 ( 261) 488 86.4 9.6e-17 XP_016875848 (OMIM: 129500,220290,304400,604418,61 ( 261) 488 86.4 9.6e-17 NP_006774 (OMIM: 129500,220290,304400,604418,61264 ( 261) 488 86.4 9.6e-17 XP_016875847 (OMIM: 129500,220290,304400,604418,61 ( 261) 488 86.4 9.6e-17 XP_016875849 (OMIM: 129500,220290,304400,604418,61 ( 261) 488 86.4 9.6e-17 NP_001103691 (OMIM: 129500,220290,304400,604418,61 ( 261) 488 86.4 9.6e-17 NP_001103690 (OMIM: 129500,220290,304400,604418,61 ( 261) 488 86.4 9.6e-17 NP_001091111 (OMIM: 302800,304040) gap junction be ( 283) 464 82.7 1.3e-15 XP_011529209 (OMIM: 302800,304040) PREDICTED: gap ( 283) 464 82.7 1.3e-15 XP_016884897 (OMIM: 302800,304040) PREDICTED: gap ( 283) 464 82.7 1.3e-15 NP_000157 (OMIM: 302800,304040) gap junction beta- ( 283) 464 82.7 1.3e-15 NP_076872 (OMIM: 133200,220290,603324,612644) gap ( 270) 463 82.5 1.4e-15 NP_001005752 (OMIM: 133200,220290,603324,612644) g ( 270) 463 82.5 1.4e-15 NP_694944 (OMIM: 133200,605425) gap junction beta- ( 266) 462 82.4 1.5e-15 XP_011538981 (OMIM: 133200,605425) PREDICTED: gap ( 266) 462 82.4 1.5e-15 XP_005256978 (OMIM: 608655) PREDICTED: gap junctio ( 396) 464 82.8 1.7e-15 NP_005488 (OMIM: 608655) gap junction gamma-1 prot ( 396) 464 82.8 1.7e-15 XP_005256977 (OMIM: 608655) PREDICTED: gap junctio ( 396) 464 82.8 1.7e-15 NP_001073852 (OMIM: 608655) gap junction gamma-1 p ( 396) 464 82.8 1.7e-15 NP_065168 (OMIM: 608803,608804,613206,613480) gap ( 439) 452 81.0 6.8e-15 XP_005270808 (OMIM: 604493) PREDICTED: gap junctio ( 273) 442 79.3 1.3e-14 NP_005259 (OMIM: 604493) gap junction beta-5 prote ( 273) 442 79.3 1.3e-14 NP_065711 (OMIM: 607058) gap junction delta-2 prot ( 321) 433 78.0 3.9e-14 NP_940970 (OMIM: 611921) gap junction beta-7 prote ( 223) 425 76.7 6.8e-14 XP_005248773 (OMIM: 611921) PREDICTED: gap junctio ( 223) 425 76.7 6.8e-14 NP_689343 (OMIM: 607425) gap junction delta-3 prot ( 294) 399 72.8 1.4e-12 XP_016877927 (OMIM: 607058) PREDICTED: gap junctio ( 270) 368 68.0 3.4e-11 NP_853516 (OMIM: 611925) gap junction gamma-3 prot ( 279) 355 66.0 1.4e-10 >>XP_011507718 (OMIM: 116200,600897,612474) PREDICTED: g (433 aa) initn: 2876 init1: 2876 opt: 2876 Z-score: 2397.5 bits: 452.7 E(85289): 8.4e-127 Smith-Waterman score: 2876; 100.0% identity (100.0% similar) in 433 aa overlap (1-433:1-433) 10 20 30 40 50 60 pF1KB7 MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 CENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHYVRMEEKRKSREAEELGQQAGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHYVRMEEKRKSREAEELGQQAGT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 NGGPDQGSVKKSSGSKGTKKFRLEGTLLRTYICHIIFKTLFEVGFIVGHYFLYGFRILPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NGGPDQGSVKKSSGSKGTKKFRLEGTLLRTYICHIIFKTLFEVGFIVGHYFLYGFRILPL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 YRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKGIRSALKRPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKGIRSALKRPV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 EQPLGEIPEKSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMVETSPLPAKPFNQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EQPLGEIPEKSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMVETSPLPAKPFNQF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 EEKISTGPLGDLSRGYQETLPSYAQVGAQEVEGEGPPAEEGAEPEVGEKKEEAERLTTEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEKISTGPLGDLSRGYQETLPSYAQVGAQEVEGEGPPAEEGAEPEVGEKKEEAERLTTEE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 QEKVAVPEGEKVETPGVDKEGEKEEPQSEKVSKQGLPAEKTPSLCPELTTDDARPLSRLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QEKVAVPEGEKVETPGVDKEGEKEEPQSEKVSKQGLPAEKTPSLCPELTTDDARPLSRLS 370 380 390 400 410 420 430 pF1KB7 KASSRARSDDLTV ::::::::::::: XP_011 KASSRARSDDLTV 430 >>NP_005258 (OMIM: 116200,600897,612474) gap junction al (433 aa) initn: 2876 init1: 2876 opt: 2876 Z-score: 2397.5 bits: 452.7 E(85289): 8.4e-127 Smith-Waterman score: 2876; 100.0% identity (100.0% similar) in 433 aa overlap (1-433:1-433) 10 20 30 40 50 60 pF1KB7 MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 CENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHYVRMEEKRKSREAEELGQQAGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 CENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHYVRMEEKRKSREAEELGQQAGT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 NGGPDQGSVKKSSGSKGTKKFRLEGTLLRTYICHIIFKTLFEVGFIVGHYFLYGFRILPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 NGGPDQGSVKKSSGSKGTKKFRLEGTLLRTYICHIIFKTLFEVGFIVGHYFLYGFRILPL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 YRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKGIRSALKRPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 YRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKGIRSALKRPV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 EQPLGEIPEKSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMVETSPLPAKPFNQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 EQPLGEIPEKSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMVETSPLPAKPFNQF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 EEKISTGPLGDLSRGYQETLPSYAQVGAQEVEGEGPPAEEGAEPEVGEKKEEAERLTTEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 EEKISTGPLGDLSRGYQETLPSYAQVGAQEVEGEGPPAEEGAEPEVGEKKEEAERLTTEE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 QEKVAVPEGEKVETPGVDKEGEKEEPQSEKVSKQGLPAEKTPSLCPELTTDDARPLSRLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 QEKVAVPEGEKVETPGVDKEGEKEEPQSEKVSKQGLPAEKTPSLCPELTTDDARPLSRLS 370 380 390 400 410 420 430 pF1KB7 KASSRARSDDLTV ::::::::::::: NP_005 KASSRARSDDLTV 430 >>XP_011507719 (OMIM: 116200,600897,612474) PREDICTED: g (427 aa) initn: 2840 init1: 2840 opt: 2840 Z-score: 2367.7 bits: 447.2 E(85289): 3.8e-125 Smith-Waterman score: 2840; 100.0% identity (100.0% similar) in 427 aa overlap (1-427:1-427) 10 20 30 40 50 60 pF1KB7 MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 CENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHYVRMEEKRKSREAEELGQQAGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHYVRMEEKRKSREAEELGQQAGT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 NGGPDQGSVKKSSGSKGTKKFRLEGTLLRTYICHIIFKTLFEVGFIVGHYFLYGFRILPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NGGPDQGSVKKSSGSKGTKKFRLEGTLLRTYICHIIFKTLFEVGFIVGHYFLYGFRILPL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 YRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKGIRSALKRPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKGIRSALKRPV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 EQPLGEIPEKSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMVETSPLPAKPFNQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EQPLGEIPEKSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMVETSPLPAKPFNQF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 EEKISTGPLGDLSRGYQETLPSYAQVGAQEVEGEGPPAEEGAEPEVGEKKEEAERLTTEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EEKISTGPLGDLSRGYQETLPSYAQVGAQEVEGEGPPAEEGAEPEVGEKKEEAERLTTEE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 QEKVAVPEGEKVETPGVDKEGEKEEPQSEKVSKQGLPAEKTPSLCPELTTDDARPLSRLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QEKVAVPEGEKVETPGVDKEGEKEEPQSEKVSKQGLPAEKTPSLCPELTTDDARPLSRLS 370 380 390 400 410 420 430 pF1KB7 KASSRARSDDLTV ::::::: XP_011 KASSRAR >>XP_011533350 (OMIM: 121015,601885) PREDICTED: gap junc (435 aa) initn: 1171 init1: 657 opt: 1175 Z-score: 987.7 bits: 191.9 E(85289): 2.8e-48 Smith-Waterman score: 1175; 45.6% identity (66.2% similar) in 447 aa overlap (1-433:1-435) 10 20 30 40 50 60 pF1KB7 MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPG :::::::: .::...:::::::.::::::::::::.::.::: :::::::::.::::::: XP_011 MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPG 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 CENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHYVRMEEKRKSREAEE-LGQQAG :::::::.::::::::.:.:::::::::.:.:.::..: ::::::.: :: :: : ... XP_011 CENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLKRESP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 TNGGPDQGSVKKSSGSKGTKKFRLEGTLLRTYICHIIFKTLFEVGFIVGHYFLYGFRILP . : : . .: ..: . :. :.:::::. .::::::::::::.:.::::::.. : XP_011 SPKEPPQDN-PSSRDDRG--RVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFELKP 130 140 150 160 170 180 190 200 210 220 230 pF1KB7 LYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKGIRSALKRP ::::.::::::.::::.::::::::::.:::.:: .::.::..:. ::: : ..... XP_011 LYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGVTSR 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 VEQPLGEIPEKSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMV--ETSPLPAKPF . .: : . . .. . . . :: .. : .: :: : XP_011 LGPDASEAPLGTADPPPLPPSSRPPAVAIGFPPYYAHTAAPLGQARAVGYPGAPPPAADF 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB7 N--QFEEKISTGPLGDLSRGYQETLPSYAQVGAQEVEGEGPPAEEGAEPEVGEKKEEAER . . : . : . : :... : . . . : .: . ::: . : : .. . XP_011 KLLALTEARGKGQSAKLYNGHHHLLMTEQNWANQAAERQ-PPALK-AYPAASTPAAPSPV 300 310 320 330 340 350 360 370 380 390 400 pF1KB7 LTT-----EEQEKVAVP---EGEKVETPGVDKEGEKEEPQSEKVSKQGLPAEKTPSLCPE .. .: : :.: .: : : :: .. .. . : XP_011 GSSSPPLAHEAEAGAAPLLLDGSGSSLEGSALAGTPEEEEQAVTTAAQMHQ-------PP 360 370 380 390 400 410 420 430 pF1KB7 LTTDDARPLSRLSKASS-RARSDDLTV : : :. :.::: ::: .::.. XP_011 LPLGDPGRASKASRASSGRARPEDLAI 410 420 430 >>NP_068773 (OMIM: 121015,601885) gap junction alpha-3 p (435 aa) initn: 1171 init1: 657 opt: 1175 Z-score: 987.7 bits: 191.9 E(85289): 2.8e-48 Smith-Waterman score: 1175; 45.6% identity (66.2% similar) in 447 aa overlap (1-433:1-435) 10 20 30 40 50 60 pF1KB7 MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPG :::::::: .::...:::::::.::::::::::::.::.::: :::::::::.::::::: NP_068 MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPG 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 CENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHYVRMEEKRKSREAEE-LGQQAG :::::::.::::::::.:.:::::::::.:.:.::..: ::::::.: :: :: : ... NP_068 CENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLKRESP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 TNGGPDQGSVKKSSGSKGTKKFRLEGTLLRTYICHIIFKTLFEVGFIVGHYFLYGFRILP . : : . .: ..: . :. :.:::::. .::::::::::::.:.::::::.. : NP_068 SPKEPPQDN-PSSRDDRG--RVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFELKP 130 140 150 160 170 180 190 200 210 220 230 pF1KB7 LYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKGIRSALKRP ::::.::::::.::::.::::::::::.:::.:: .::.::..:. ::: : ..... NP_068 LYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGVTSR 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 VEQPLGEIPEKSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMV--ETSPLPAKPF . .: : . . .. . . . :: .. : .: :: : NP_068 LGPDASEAPLGTADPPPLPPSSRPPAVAIGFPPYYAHTAAPLGQARAVGYPGAPPPAADF 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB7 N--QFEEKISTGPLGDLSRGYQETLPSYAQVGAQEVEGEGPPAEEGAEPEVGEKKEEAER . . : . : . : :... : . . . : .: . ::: . : : .. . NP_068 KLLALTEARGKGQSAKLYNGHHHLLMTEQNWANQAAERQ-PPALK-AYPAASTPAAPSPV 300 310 320 330 340 350 360 370 380 390 400 pF1KB7 LTT-----EEQEKVAVP---EGEKVETPGVDKEGEKEEPQSEKVSKQGLPAEKTPSLCPE .. .: : :.: .: : : :: .. .. . : NP_068 GSSSPPLAHEAEAGAAPLLLDGSGSSLEGSALAGTPEEEEQAVTTAAQMHQ-------PP 360 370 380 390 400 410 420 430 pF1KB7 LTTDDARPLSRLSKASS-RARSDDLTV : : :. :.::: ::: .::.. NP_068 LPLGDPGRASKASRASSGRARPEDLAI 410 420 430 >>XP_016856533 (OMIM: 108770,121013,612474,614049) PREDI (358 aa) initn: 1104 init1: 649 opt: 1032 Z-score: 870.4 bits: 169.9 E(85289): 9.6e-42 Smith-Waterman score: 1032; 61.8% identity (83.8% similar) in 241 aa overlap (1-239:1-241) 10 20 30 40 50 60 pF1KB7 MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPG :::::::::.::::..::::.:.::::::::::.:.:::::: :::::.:: :.: ::: XP_016 MGDWSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 CENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHYVRMEEKRKSREAEELGQQAGT :.:::::.:::::::: :::::::::::::.:.:::.: :::.:::: ::::. . :. XP_016 CQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKRKLREAERAKEVRGS 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 NGG--PDQGSVKKSSGSKGTKKFRLEGTLLRTYICHIIFKTLFEVGFIVGHYFLYGFRIL .. : ... : .:. .. :.:::: ::.: :...: .:::::::.::.::. . XP_016 GSYEYPVAEKAELSCWEEGNGRIALQGTLLNTYVCSILIRTTMEVGFIVGQYFIYGIFLT 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 PLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKGIRSALKR :. : : :::. :.:.:::::::..::.:::.::..::.:.. :: ::: : ::. . . XP_016 TLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLGWKKIRQRFVK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB7 PVEQPLGEIPEKSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMVETSPLPAKPFN : XP_016 PRQHMAKCQLSGPSVGIVQSCTPPPDFNQCLENGPGGKFFNPFSNNMASQQNTDNLVTEQ 250 260 270 280 290 300 >>NP_005257 (OMIM: 108770,121013,612474,614049) gap junc (358 aa) initn: 1104 init1: 649 opt: 1032 Z-score: 870.4 bits: 169.9 E(85289): 9.6e-42 Smith-Waterman score: 1032; 61.8% identity (83.8% similar) in 241 aa overlap (1-239:1-241) 10 20 30 40 50 60 pF1KB7 MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPG :::::::::.::::..::::.:.::::::::::.:.:::::: :::::.:: :.: ::: NP_005 MGDWSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 CENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHYVRMEEKRKSREAEELGQQAGT :.:::::.:::::::: :::::::::::::.:.:::.: :::.:::: ::::. . :. NP_005 CQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKRKLREAERAKEVRGS 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 NGG--PDQGSVKKSSGSKGTKKFRLEGTLLRTYICHIIFKTLFEVGFIVGHYFLYGFRIL .. : ... : .:. .. :.:::: ::.: :...: .:::::::.::.::. . NP_005 GSYEYPVAEKAELSCWEEGNGRIALQGTLLNTYVCSILIRTTMEVGFIVGQYFIYGIFLT 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 PLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKGIRSALKR :. : : :::. :.:.:::::::..::.:::.::..::.:.. :: ::: : ::. . . NP_005 TLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLGWKKIRQRFVK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB7 PVEQPLGEIPEKSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMVETSPLPAKPFN : NP_005 PRQHMAKCQLSGPSVGIVQSCTPPPDFNQCLENGPGGKFFNPFSNNMASQQNTDNLVTEQ 250 260 270 280 290 300 >>XP_005273008 (OMIM: 108770,121013,612474,614049) PREDI (358 aa) initn: 1104 init1: 649 opt: 1032 Z-score: 870.4 bits: 169.9 E(85289): 9.6e-42 Smith-Waterman score: 1032; 61.8% identity (83.8% similar) in 241 aa overlap (1-239:1-241) 10 20 30 40 50 60 pF1KB7 MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPG :::::::::.::::..::::.:.::::::::::.:.:::::: :::::.:: :.: ::: XP_005 MGDWSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 CENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHYVRMEEKRKSREAEELGQQAGT :.:::::.:::::::: :::::::::::::.:.:::.: :::.:::: ::::. . :. XP_005 CQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKRKLREAERAKEVRGS 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 NGG--PDQGSVKKSSGSKGTKKFRLEGTLLRTYICHIIFKTLFEVGFIVGHYFLYGFRIL .. : ... : .:. .. :.:::: ::.: :...: .:::::::.::.::. . XP_005 GSYEYPVAEKAELSCWEEGNGRIALQGTLLNTYVCSILIRTTMEVGFIVGQYFIYGIFLT 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 PLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKGIRSALKR :. : : :::. :.:.:::::::..::.:::.::..::.:.. :: ::: : ::. . . XP_005 TLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLGWKKIRQRFVK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB7 PVEQPLGEIPEKSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMVETSPLPAKPFN : XP_005 PRQHMAKCQLSGPSVGIVQSCTPPPDFNQCLENGPGGKFFNPFSNNMASQQNTDNLVTEQ 250 260 270 280 290 300 >>NP_859054 (OMIM: 108770,121013,612474,614049) gap junc (358 aa) initn: 1104 init1: 649 opt: 1032 Z-score: 870.4 bits: 169.9 E(85289): 9.6e-42 Smith-Waterman score: 1032; 61.8% identity (83.8% similar) in 241 aa overlap (1-239:1-241) 10 20 30 40 50 60 pF1KB7 MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPG :::::::::.::::..::::.:.::::::::::.:.:::::: :::::.:: :.: ::: NP_859 MGDWSFLGNFLEEVHKHSTVVGKVWLTVLFIFRMLVLGTAAESSWGDEQADFRCDTIQPG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 CENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHYVRMEEKRKSREAEELGQQAGT :.:::::.:::::::: :::::::::::::.:.:::.: :::.:::: ::::. . :. NP_859 CQNVCYDQAFPISHIRYWVLQIIFVSTPSLVYMGHAMHTVRMQEKRKLREAERAKEVRGS 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 NGG--PDQGSVKKSSGSKGTKKFRLEGTLLRTYICHIIFKTLFEVGFIVGHYFLYGFRIL .. : ... : .:. .. :.:::: ::.: :...: .:::::::.::.::. . NP_859 GSYEYPVAEKAELSCWEEGNGRIALQGTLLNTYVCSILIRTTMEVGFIVGQYFIYGIFLT 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 PLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKGIRSALKR :. : : :::. :.:.:::::::..::.:::.::..::.:.. :: ::: : ::. . . NP_859 TLHVCRRSPCPHPVNCYVSRPTEKNVFIVFMLAVAALSLLLSLAELYHLGWKKIRQRFVK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB7 PVEQPLGEIPEKSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMVETSPLPAKPFN : NP_859 PRQHMAKCQLSGPSVGIVQSCTPPPDFNQCLENGPGGKFFNPFSNNMASQQNTDNLVTEQ 250 260 270 280 290 300 >>NP_115991 (OMIM: 611924) gap junction alpha-10 protein (543 aa) initn: 973 init1: 557 opt: 955 Z-score: 803.9 bits: 158.2 E(85289): 4.9e-38 Smith-Waterman score: 963; 38.2% identity (66.2% similar) in 456 aa overlap (1-429:1-439) 10 20 30 40 50 60 pF1KB7 MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPG ::::..::.:::::. :::..:..:::.:::::.:.: .::: :: :::: :.:::.::: NP_115 MGDWNLLGGILEEVHSHSTIVGKIWLTILFIFRMLVLRVAAEDVWDDEQSAFACNTRQPG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 CENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHYVRMEEKRKSREAEELGQQAGT :.:.:::.::::: ::.:::::::::.:::.:.:::.. .: :: ..:. .: : . NP_115 CNNICYDDAFPISLIRFWVLQIIFVSSPSLVYMGHALYRLRAFEKDRQRKKSHLRAQMEN 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 NGGPD-----QGSV----KKSSGSKGTKKFRLEGTLLRTYICHIIFKTLFEVGFIVGHYF :: : . .. .: .: :.: :::::. ::. ....::::..:.:. NP_115 ---PDLDLEEQQRIDRELRRLEEQKRIHKVPLKGCLLRTYVLHILTRSVLEVGFMIGQYI 130 140 150 160 170 180 190 200 210 220 230 pF1KB7 LYGFRILPLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVASVSLFLNVMELGHLGLKG ::::.. :::.:.. ::::.::::::::::::::.::: :.:..::.::..:. :::.. NP_115 LYGFQMHPLYKCTQPPCPNAVDCFVSRPTEKTIFMLFMHSIAAISLLLNILEIFHLGIRK 180 190 200 210 220 230 240 250 260 270 280 pF1KB7 I-RSALKRP----VEQPLGEIPEKSLHSIA-----VSSI-QKAKGYQLLEEEKIVSHYFP : :. :. .:. : . . .:.: ::. .. . : ...... : NP_115 IMRTLYKKSSSEGIEDETGPPFHLKKYSVAQQCMICSSLPERISPLQANNQQQVIRVNVP 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB7 LTEVGMVETSPLPAKPFNQFEEKISTGPLGDLSRGYQETLPSYAQVGAQEVEGEGPPAEE ... : . : : :.: :.: : :. :.. : .:.. : : NP_115 KSKT-MWQI-PQP----RQLEVDPSNGK-KDWSEKDQHS-------GQLHVHSPCPWAGS 300 310 320 330 340 350 360 370 380 390 pF1KB7 GAEPEVGEKKEEA-----ERLTTEEQEKVAVPEGEKVETPGVDKEGEKEEPQSEKVSKQG ... ..:...... . .. ...:.. . :. .... ::..: .. NP_115 AGNQHLGQQSDHSSFGLQNTMSQSWLGTTTAPRNCPSFAVGTWEQSQDPEPSGEPLTDLH 350 360 370 380 390 400 400 410 420 430 pF1KB7 LPAEKTPSLCPE--LTTDDARPLSRLSKASSRARSDDLTV . . . : . : .:: :: .. :: :. NP_115 SHCRDSEGSMRESGVWIDRSRPGSRKASFLSRLLSEKRHLHSDSGSSGSRNSSCLDFPHW 410 420 430 440 450 460 NP_115 ENSPSPLPSVTGHRTSMVRQAALPIMELSQELFHSGCFLFPFFLPGVCMYVCVDREADGG 470 480 490 500 510 520 433 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 05:34:54 2016 done: Fri Nov 4 05:34:56 2016 Total Scan time: 10.120 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]