Result of FASTA (omim) for
pF1KB7172
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7172, 491 aa
1>>>pF1KB7172 491 - 491 aa - 491 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6208+/-0.000469; mu= 16.0208+/- 0.029
mean_var=96.8190+/-19.867, 0's: 0 Z-trim(109.6): 264 B-trim: 147 in 1/54
Lambda= 0.130345
statistics sampled from 17398 (17822) to 17398 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.559), E-opt: 0.2 (0.209), width: 16
Scan time: 7.670
The best scores are: opt bits E(85289)
XP_016859548 (OMIM: 603888) PREDICTED: potassium v ( 491) 3279 628.0 1.8e-179
XP_011531127 (OMIM: 603888) PREDICTED: potassium v ( 491) 3279 628.0 1.8e-179
NP_002243 (OMIM: 603888) potassium voltage-gated c ( 491) 3279 628.0 1.8e-179
NP_001269357 (OMIM: 603888) potassium voltage-gate ( 491) 3279 628.0 1.8e-179
NP_065748 (OMIM: 602906) potassium voltage-gated c ( 477) 1702 331.5 3.3e-90
NP_598004 (OMIM: 607604,610356) potassium voltage- ( 545) 1017 202.7 2.2e-51
NP_758857 (OMIM: 607603) potassium voltage-gated c ( 519) 967 193.3 1.4e-48
XP_011527107 (OMIM: 603788) PREDICTED: potassium v ( 513) 965 192.9 1.8e-48
XP_011527108 (OMIM: 603788) PREDICTED: potassium v ( 513) 965 192.9 1.8e-48
XP_011527102 (OMIM: 603788) PREDICTED: potassium v ( 513) 965 192.9 1.8e-48
XP_006723848 (OMIM: 603788) PREDICTED: potassium v ( 513) 965 192.9 1.8e-48
XP_011527104 (OMIM: 603788) PREDICTED: potassium v ( 513) 965 192.9 1.8e-48
NP_002228 (OMIM: 603788) potassium voltage-gated c ( 513) 965 192.9 1.8e-48
XP_011527106 (OMIM: 603788) PREDICTED: potassium v ( 513) 965 192.9 1.8e-48
XP_011527105 (OMIM: 603788) PREDICTED: potassium v ( 513) 965 192.9 1.8e-48
XP_011527103 (OMIM: 603788) PREDICTED: potassium v ( 513) 965 192.9 1.8e-48
NP_004761 (OMIM: 607738) potassium voltage-gated c ( 911) 911 183.0 3.2e-45
NP_004966 (OMIM: 600397,616056) potassium voltage- ( 858) 896 180.1 2.2e-44
XP_011527101 (OMIM: 600397,616056) PREDICTED: pota ( 858) 896 180.1 2.2e-44
XP_006723847 (OMIM: 600397,616056) PREDICTED: pota ( 858) 896 180.1 2.2e-44
NP_758847 (OMIM: 606767) potassium voltage-gated c ( 425) 885 177.8 5.4e-44
NP_036415 (OMIM: 605696) potassium voltage-gated c ( 466) 837 168.8 3e-41
XP_016881194 (OMIM: 605696) PREDICTED: potassium v ( 466) 837 168.8 3e-41
XP_011524220 (OMIM: 605696) PREDICTED: potassium v ( 466) 837 168.8 3e-41
XP_011524222 (OMIM: 605696) PREDICTED: potassium v ( 466) 837 168.8 3e-41
XP_016881193 (OMIM: 605696) PREDICTED: potassium v ( 509) 837 168.8 3.2e-41
NP_055194 (OMIM: 608164) potassium voltage-gated c ( 500) 812 164.1 8.3e-40
NP_579875 (OMIM: 606767) potassium voltage-gated c ( 436) 796 161.0 6e-39
NP_002227 (OMIM: 603787) potassium voltage-gated c ( 494) 766 155.5 3.3e-37
XP_016869471 (OMIM: 607738) PREDICTED: potassium v ( 666) 706 144.3 1e-33
XP_016869470 (OMIM: 607738) PREDICTED: potassium v ( 666) 706 144.3 1e-33
NP_002224 (OMIM: 176266) potassium voltage-gated c ( 653) 701 143.3 1.9e-33
NP_002223 (OMIM: 176263) potassium voltage-gated c ( 575) 674 138.2 6e-32
XP_011539699 (OMIM: 176262,616366) PREDICTED: pota ( 499) 655 134.6 6.4e-31
NP_004965 (OMIM: 176262,616366) potassium voltage- ( 499) 655 134.6 6.4e-31
XP_011539698 (OMIM: 176262,616366) PREDICTED: pota ( 499) 655 134.6 6.4e-31
XP_011539702 (OMIM: 176262,616366) PREDICTED: pota ( 499) 655 134.6 6.4e-31
XP_011539701 (OMIM: 176262,616366) PREDICTED: pota ( 499) 655 134.6 6.4e-31
XP_016856702 (OMIM: 176262,616366) PREDICTED: pota ( 499) 655 134.6 6.4e-31
XP_011539700 (OMIM: 176262,616366) PREDICTED: pota ( 499) 655 134.6 6.4e-31
NP_002242 (OMIM: 602905) potassium voltage-gated c ( 526) 642 132.2 3.6e-30
NP_001309728 (OMIM: 602905) potassium voltage-gate ( 526) 642 132.2 3.6e-30
XP_016883335 (OMIM: 602905) PREDICTED: potassium v ( 527) 642 132.2 3.6e-30
NP_114092 (OMIM: 176268) potassium voltage-gated c ( 456) 640 131.7 4.2e-30
NP_000208 (OMIM: 160120,176260) potassium voltage- ( 495) 626 129.1 2.8e-29
NP_005540 (OMIM: 602420) potassium voltage-gated c ( 511) 626 129.1 2.9e-29
NP_002225 (OMIM: 176267,612240) potassium voltage- ( 613) 605 125.3 5e-28
XP_016884997 (OMIM: 300281) PREDICTED: potassium v ( 558) 564 117.5 9.8e-26
XP_016884998 (OMIM: 300281) PREDICTED: potassium v ( 558) 564 117.5 9.8e-26
XP_011542212 (OMIM: 300281) PREDICTED: potassium v ( 647) 564 117.6 1.1e-25
>>XP_016859548 (OMIM: 603888) PREDICTED: potassium volta (491 aa)
initn: 3279 init1: 3279 opt: 3279 Z-score: 3343.0 bits: 628.0 E(85289): 1.8e-179
Smith-Waterman score: 3279; 99.8% identity (100.0% similar) in 491 aa overlap (1-491:1-491)
10 20 30 40 50 60
pF1KB7 MVFGEFFHRPGQDEELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MVFGEFFHRPGQDEELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 SVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCVFSFCQEIEYWGINELFIDSCCSNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCVFSFCQEIEYWGINELFIDSCCSNR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 YQERKEENHEKDWDQKSHDVSTDSSFEESSLFEKELEKFDTLRFGQLRKKIWIRMENPAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YQERKEENHEKDWDQKSHDVSTDSSFEESSLFEKELEKFDTLRFGQLRKKIWIRMENPAY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 CLSAKLIAISSLSVVLASIVAMCVHSMSEFQNEDGEVDDPVLEGVEIACIAWFTGELAVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CLSAKLIAISSLSVVLASIVAMCVHSMSEFQNEDGEVDDPVLEGVEIACIAWFTGELAVR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 LAAAPCQKKFWKNPLNIIDFVSIIPFYATLAVDTKEEESEDIENMGKVVQILRLMRIFRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAAAPCQKKFWKNPLNIIDFVSIIPFYATLAVDTKEEESEDIENMGKVVQILRLMRIFRI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 LKLARHSVGLRSLGATLRHSYHEVGLLLLFLSVGISIFSVLIYSVEKDDHTSSLTSIPIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKLARHSVGLRSLGATLRHSYHEVGLLLLFLSVGISIFSVLIYSVEKDDHTSSLTSIPIC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 WWWATISMTTVGYGDTHPVTLAGKLIASTCIICGILVVALPITIIFNKFSKYYQKQKDID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WWWATISMTTVGYGDTHPVTLAGKLIASTCIICGILVVALPITIIFNKFSKYYQKQKDID
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB7 VDQCSEDAPEKCHELPYFNIRDIYAQRMHAFITSLSSVGIVVSDPDSTDASSIEDNEDIC
:::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::
XP_016 VDQCSEDAPEKCHELPYFNIRDIYAQRMHTFITSLSSVGIVVSDPDSTDASSIEDNEDIC
430 440 450 460 470 480
490
pF1KB7 NTTSLENCTAK
:::::::::::
XP_016 NTTSLENCTAK
490
>>XP_011531127 (OMIM: 603888) PREDICTED: potassium volta (491 aa)
initn: 3279 init1: 3279 opt: 3279 Z-score: 3343.0 bits: 628.0 E(85289): 1.8e-179
Smith-Waterman score: 3279; 99.8% identity (100.0% similar) in 491 aa overlap (1-491:1-491)
10 20 30 40 50 60
pF1KB7 MVFGEFFHRPGQDEELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MVFGEFFHRPGQDEELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 SVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCVFSFCQEIEYWGINELFIDSCCSNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCVFSFCQEIEYWGINELFIDSCCSNR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 YQERKEENHEKDWDQKSHDVSTDSSFEESSLFEKELEKFDTLRFGQLRKKIWIRMENPAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YQERKEENHEKDWDQKSHDVSTDSSFEESSLFEKELEKFDTLRFGQLRKKIWIRMENPAY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 CLSAKLIAISSLSVVLASIVAMCVHSMSEFQNEDGEVDDPVLEGVEIACIAWFTGELAVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CLSAKLIAISSLSVVLASIVAMCVHSMSEFQNEDGEVDDPVLEGVEIACIAWFTGELAVR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 LAAAPCQKKFWKNPLNIIDFVSIIPFYATLAVDTKEEESEDIENMGKVVQILRLMRIFRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAAAPCQKKFWKNPLNIIDFVSIIPFYATLAVDTKEEESEDIENMGKVVQILRLMRIFRI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 LKLARHSVGLRSLGATLRHSYHEVGLLLLFLSVGISIFSVLIYSVEKDDHTSSLTSIPIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKLARHSVGLRSLGATLRHSYHEVGLLLLFLSVGISIFSVLIYSVEKDDHTSSLTSIPIC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 WWWATISMTTVGYGDTHPVTLAGKLIASTCIICGILVVALPITIIFNKFSKYYQKQKDID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WWWATISMTTVGYGDTHPVTLAGKLIASTCIICGILVVALPITIIFNKFSKYYQKQKDID
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB7 VDQCSEDAPEKCHELPYFNIRDIYAQRMHAFITSLSSVGIVVSDPDSTDASSIEDNEDIC
:::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::
XP_011 VDQCSEDAPEKCHELPYFNIRDIYAQRMHTFITSLSSVGIVVSDPDSTDASSIEDNEDIC
430 440 450 460 470 480
490
pF1KB7 NTTSLENCTAK
:::::::::::
XP_011 NTTSLENCTAK
490
>>NP_002243 (OMIM: 603888) potassium voltage-gated chann (491 aa)
initn: 3279 init1: 3279 opt: 3279 Z-score: 3343.0 bits: 628.0 E(85289): 1.8e-179
Smith-Waterman score: 3279; 99.8% identity (100.0% similar) in 491 aa overlap (1-491:1-491)
10 20 30 40 50 60
pF1KB7 MVFGEFFHRPGQDEELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MVFGEFFHRPGQDEELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 SVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCVFSFCQEIEYWGINELFIDSCCSNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCVFSFCQEIEYWGINELFIDSCCSNR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 YQERKEENHEKDWDQKSHDVSTDSSFEESSLFEKELEKFDTLRFGQLRKKIWIRMENPAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 YQERKEENHEKDWDQKSHDVSTDSSFEESSLFEKELEKFDTLRFGQLRKKIWIRMENPAY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 CLSAKLIAISSLSVVLASIVAMCVHSMSEFQNEDGEVDDPVLEGVEIACIAWFTGELAVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 CLSAKLIAISSLSVVLASIVAMCVHSMSEFQNEDGEVDDPVLEGVEIACIAWFTGELAVR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 LAAAPCQKKFWKNPLNIIDFVSIIPFYATLAVDTKEEESEDIENMGKVVQILRLMRIFRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LAAAPCQKKFWKNPLNIIDFVSIIPFYATLAVDTKEEESEDIENMGKVVQILRLMRIFRI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 LKLARHSVGLRSLGATLRHSYHEVGLLLLFLSVGISIFSVLIYSVEKDDHTSSLTSIPIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LKLARHSVGLRSLGATLRHSYHEVGLLLLFLSVGISIFSVLIYSVEKDDHTSSLTSIPIC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 WWWATISMTTVGYGDTHPVTLAGKLIASTCIICGILVVALPITIIFNKFSKYYQKQKDID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 WWWATISMTTVGYGDTHPVTLAGKLIASTCIICGILVVALPITIIFNKFSKYYQKQKDID
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB7 VDQCSEDAPEKCHELPYFNIRDIYAQRMHAFITSLSSVGIVVSDPDSTDASSIEDNEDIC
:::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::
NP_002 VDQCSEDAPEKCHELPYFNIRDIYAQRMHTFITSLSSVGIVVSDPDSTDASSIEDNEDIC
430 440 450 460 470 480
490
pF1KB7 NTTSLENCTAK
:::::::::::
NP_002 NTTSLENCTAK
490
>>NP_001269357 (OMIM: 603888) potassium voltage-gated ch (491 aa)
initn: 3279 init1: 3279 opt: 3279 Z-score: 3343.0 bits: 628.0 E(85289): 1.8e-179
Smith-Waterman score: 3279; 99.8% identity (100.0% similar) in 491 aa overlap (1-491:1-491)
10 20 30 40 50 60
pF1KB7 MVFGEFFHRPGQDEELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVFGEFFHRPGQDEELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 SVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCVFSFCQEIEYWGINELFIDSCCSNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCVFSFCQEIEYWGINELFIDSCCSNR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 YQERKEENHEKDWDQKSHDVSTDSSFEESSLFEKELEKFDTLRFGQLRKKIWIRMENPAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YQERKEENHEKDWDQKSHDVSTDSSFEESSLFEKELEKFDTLRFGQLRKKIWIRMENPAY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 CLSAKLIAISSLSVVLASIVAMCVHSMSEFQNEDGEVDDPVLEGVEIACIAWFTGELAVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CLSAKLIAISSLSVVLASIVAMCVHSMSEFQNEDGEVDDPVLEGVEIACIAWFTGELAVR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 LAAAPCQKKFWKNPLNIIDFVSIIPFYATLAVDTKEEESEDIENMGKVVQILRLMRIFRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAAAPCQKKFWKNPLNIIDFVSIIPFYATLAVDTKEEESEDIENMGKVVQILRLMRIFRI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 LKLARHSVGLRSLGATLRHSYHEVGLLLLFLSVGISIFSVLIYSVEKDDHTSSLTSIPIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKLARHSVGLRSLGATLRHSYHEVGLLLLFLSVGISIFSVLIYSVEKDDHTSSLTSIPIC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 WWWATISMTTVGYGDTHPVTLAGKLIASTCIICGILVVALPITIIFNKFSKYYQKQKDID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WWWATISMTTVGYGDTHPVTLAGKLIASTCIICGILVVALPITIIFNKFSKYYQKQKDID
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB7 VDQCSEDAPEKCHELPYFNIRDIYAQRMHAFITSLSSVGIVVSDPDSTDASSIEDNEDIC
:::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::
NP_001 VDQCSEDAPEKCHELPYFNIRDIYAQRMHTFITSLSSVGIVVSDPDSTDASSIEDNEDIC
430 440 450 460 470 480
490
pF1KB7 NTTSLENCTAK
:::::::::::
NP_001 NTTSLENCTAK
490
>>NP_065748 (OMIM: 602906) potassium voltage-gated chann (477 aa)
initn: 1722 init1: 798 opt: 1702 Z-score: 1740.4 bits: 331.5 E(85289): 3.3e-90
Smith-Waterman score: 1702; 56.4% identity (82.2% similar) in 450 aa overlap (12-458:15-462)
10 20 30 40 50
pF1KB7 MVFGEFFHRPGQDEELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELC
.: : . .::::::. . . ::::::.::::.:: :::.:::::::
NP_065 MTGQSLWDVSEANVEDGE-IRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELC
10 20 30 40 50
60 70 80 90 100 110
pF1KB7 DDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCVFSFCQEIEYWGINELFIDSCC
:::. ...:.:::::: :: :::.::.::::::: ::::::: ::::::::::.::::::
NP_065 DDYDDVQREFYFDRNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCC
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB7 SNRYQERKEENHEKDWDQKSHDVSTDSSFEESSLFEKELEKFDTLRFGQLRKKIWIRMEN
: :. :: : ... ::..: . :: :::.: : .. ::: .:..:...:. ..:
NP_065 SYSYHGRKVEPEQEKWDEQSDQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDN
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB7 PAYCLSAKLIAISSLSVVLASIVAMCVHSMSEFQNEDGEVD---DPVLEGVEIACIAWFT
:.: . .....: :. ::..::..::..:. .:: :.. . :: .: :: :::::
NP_065 PGYSVLSRVFSILSILVVMGSIITMCLNSLPDFQIPDSQGNPGEDPRFEIVEHFGIAWFT
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB7 GELAVRLAAAPCQKKFWKNPLNIIDFVSIIPFYATLAVDTKEEESEDIENMGKVVQILRL
::..:.:.:: ::.:: ::.::..::.::: ::.:. : . . :.:.:.:.:::
NP_065 FELVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVNLVVESTPTLANLGRVAQVLRL
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB7 MRIFRILKLARHSVGLRSLGATLRHSYHEVGLLLLFLSVGISIFSVLIYSVEKDDHTSSL
:::::::::::::.:::::::::..::.:::::::.::::::::::. :..::... . :
NP_065 MRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEKEENEG-L
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB7 TSIPICWWWATISMTTVGYGDTHPVTLAGKLIASTCIICGILVVALPITIIFNKFSKYYQ
..:: ::::::.:::::::::. : : :::: ::.::. :::::.::::.::::::..:.
NP_065 ATIPACWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFYR
360 370 380 390 400 410
420 430 440 450 460 470
pF1KB7 KQKDIDVDQCSEDAPEKCHELPYFNIRDIYAQRMHAFITSLSSVGIVVSDPDSTDASSIE
.::... . : : . .:.: :.:: ::........::...
NP_065 RQKQLESAMRSCDFGDGMKEVPSVNLRDYYAHKVKSLMASLTNMSRSSPSELSLNDSLR
420 430 440 450 460 470
480 490
pF1KB7 DNEDICNTTSLENCTAK
>>NP_598004 (OMIM: 607604,610356) potassium voltage-gate (545 aa)
initn: 1025 init1: 496 opt: 1017 Z-score: 1043.5 bits: 202.7 E(85289): 2.2e-51
Smith-Waterman score: 1102; 42.5% identity (71.0% similar) in 414 aa overlap (17-417:99-504)
10 20 30 40
pF1KB7 MVFGEFFHRPGQDEELVNLNVGGFKQSVDQSTLLRFPHTRLGKLLT
.:.:::: . ..: : ::.::::.: :
NP_598 DDLAEEDQQAGEVTTAKPEGPSDPPALLSTLNVNVGGHSYQLDYCELAGFPKTRLGRLAT
70 80 90 100 110 120
50 60 70 80 90 100
pF1KB7 CHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCVFSFCQEIEYW
:. : ::::: ::.:::.:..:. : ::: .: : :.. :: : .:. ::
NP_598 STSRSRQLSLCDDYEEQTDEYFFDRDPAVFQLVYNFYLSGVLLVLDGLCPRRFLEELGYW
130 140 150 160 170 180
110 120 130 140 150 160
pF1KB7 GINELFIDSCCSNRYQERKEENHEKDWDQKSHDVSTDSSFEESSLFEKELEKFDTLRF-G
:. . :: ..::..: :. : :.. .... ::. .:: : .:: :
NP_598 GVRLKYTPRCCRICFEERRDELSERLKIQ--HELRAQAQVEEA----EEL--FRDMRFYG
190 200 210 220 230 240
170 180 190 200 210 220
pF1KB7 QLRKKIWIRMENPAYCLSAKLIAISSLSVVLASIVAMCVHSMSEFQNEDGEVDD-----P
:...: ::.: ..:: :...: . ::.:.::. .... :.:...:. . :
NP_598 PQRRRLWNLMEKPFSSVAAKAIGVASSTFVLVSVVALALNTVEEMQQHSGQGEGGPDLRP
250 260 270 280 290 300
230 240 250 260 270
pF1KB7 VLEGVEIACIAWFTGELAVRLAAAPCQKKFWKNPLNIIDFVSIIPFYATLAVD--TKE--
.:: ::. :...:: : .:::..: ..: .. ::..:.:.:.:.: : .. : :
NP_598 ILEHVEMLCMGFFTLEYLLRLASTPDLRRFARSALNLVDLVAILPLYLQLLLECFTGEGH
310 320 330 340 350 360
280 290 300 310 320 330
pF1KB7 EESEDIENMGKVVQILR---LMRIFRILKLARHSVGLRSLGATLRHSYHEVGLLLLFLSV
.... . ..::: :.:: ::::::::::::::.:::..: :::. :..:: ::::...
NP_598 QRGQTVGSVGKVGQVLRVMRLMRIFRILKLARHSTGLRAFGFTLRQCYQQVGCLLLFIAM
370 380 390 400 410 420
340 350 360 370 380 390
pF1KB7 GISIFSVLIYSVEKDDHTSSLTSIPICWWWATISMTTVGYGDTHPVTLAGKLIASTCIIC
:: ::. .::::.: ....:.:: ::::..:..:::::: .: : :...: ::
NP_598 GIFTFSAAVYSVEHDVPSTNFTTIPHSWWWAAVSISTVGYGDMYPETHLGRFFAFLCIAF
430 440 450 460 470 480
400 410 420 430 440 450
pF1KB7 GILVVALPITIIFNKFSKYYQKQKDIDVDQCSEDAPEKCHELPYFNIRDIYAQRMHAFIT
::.. ..::.:..:::: ::.: :
NP_598 GIILNGMPISILYNKFSDYYSKLKAYEYTTIRRERGEVNFMQRARKKIAECLLGSNPQLT
490 500 510 520 530 540
>>NP_758857 (OMIM: 607603) potassium voltage-gated chann (519 aa)
initn: 978 init1: 354 opt: 967 Z-score: 993.0 bits: 193.3 E(85289): 1.4e-48
Smith-Waterman score: 967; 39.1% identity (67.8% similar) in 422 aa overlap (10-417:54-465)
10 20 30
pF1KB7 MVFGEFFHRPGQDEELVNLNVGGFKQSVDQSTLLRFPHT
: . .. . .:::: . . ::: ::: .
NP_758 SQLLSSPMETPSIKGLYYRRVRKVGALDASPVDLKKEILINVGGRRYLLPWSTLDRFPLS
30 40 50 60 70 80
40 50 60 70 80 90
pF1KB7 RLGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCVFSF
::.:: :.: : :..:::::. ..:..:::.:: : ...: .::: ...:.:..::
NP_758 RLSKLRLCRSYEEIVQLCDDYDEDSQEFFFDRSPSAFGVIVSFLAAGKLVLLQEMCALSF
90 100 110 120 130 140
100 110 120 130 140 150
pF1KB7 CQEIEYWGINELFIDSCCSNRYQERKEENHEKDWDQKSHDVSTDSSFEESSLFEKELEKF
.:. ::::.: .. :: : :: :. :. . .:: .. : .
NP_758 QEELAYWGIEEAHLERCCL-RKLLRKLEELEELAKLHREDVLRQQR-------ETRRPAS
150 160 170 180 190
160 170 180 190 200 210
pF1KB7 DTLRFGQLRKKIWIRMENPAYCLSAKLIAISSLSVVLASIVAMCVHSMSEFQNED--GEV
. :.: ... .::: : .:..: :. : .. :..:: .: ... :. ::
NP_758 HSSRWGLCMNRLREMVENPQSGLPGKVFACLSILFVATTAVSLCVSTMPDLRAEEDQGEC
200 210 220 230 240 250
220 230 240 250 260 270
pF1KB7 DDPV--LEGVEIACIAWFTGELAVRLAAAPCQKKFWKNPLNIIDFVSIIPFYATLAVDTK
. . :: :.:::. :. .:.. : . .:...::::::...: :.:..:::.
NP_758 SRKCYYIFIVETICVAWFSLEFCLRFVQAQDKCQFFQGPLNIIDILAISPYYVSLAVS--
260 270 280 290 300 310
280 290 300 310 320
pF1KB7 EEESED---------IENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRHSYHEVGL
:: :: .:..: :...:: .::. ...:::::.::..:: :.:. .: ::
NP_758 EEPPEDGERPSGSSYLEKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTVRRCTREFGL
320 330 340 350 360 370
330 340 350 360 370 380
pF1KB7 LLLFLSVGISIFSVLIYSVEKDD-HTSSLTSIPICWWWATISMTTVGYGDTHPVTLAGKL
:::::.:.:..:: :.: .::.. .. .:::: .::: :::::::::: : .. :..
NP_758 LLLFLAVAITLFSPLVYVAEKESGRVLEFTSIPASYWWAIISMTTVGYGDMVPRSVPGQM
380 390 400 410 420 430
390 400 410 420 430 440
pF1KB7 IASTCIICGILVVALPITIIFNKFSKYYQKQKDIDVDQCSEDAPEKCHELPYFNIRDIYA
.: . :. :::..:.: : ::. ::. : . :
NP_758 VALSSILSGILIMAFPATSIFHTFSHSYLELKKEQEQLQARLRHLQNTGPASECELLDPH
440 450 460 470 480 490
450 460 470 480 490
pF1KB7 QRMHAFITSLSSVGIVVSDPDSTDASSIEDNEDICNTTSLENCTAK
NP_758 VASEHELMNDVNDLILEGPALPIMHM
500 510
>>XP_011527107 (OMIM: 603788) PREDICTED: potassium volta (513 aa)
initn: 981 init1: 381 opt: 965 Z-score: 991.0 bits: 192.9 E(85289): 1.8e-48
Smith-Waterman score: 965; 38.0% identity (68.2% similar) in 421 aa overlap (9-417:57-471)
10 20 30
pF1KB7 MVFGEFFHRPGQDEELVNLNVGGFKQSVDQSTLLRFPH
.: . .. . .::::.: :. .:: .::
XP_011 AFLPQRQAIKGAFYRRAQRLRPQDEPRQGCQPEDRRRRIIINVGGIKYSLPWTTLDEFPL
30 40 50 60 70 80
40 50 60 70 80 90
pF1KB7 TRLGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCVFS
::::.: .: . . ::..::::.:. .:..:::::. : .:.: .:::....:.:..:
XP_011 TRLGQLKACTNFDDILNVCDDYDVTCNEFFFDRNPGAFGTILTFLRAGKLRLLREMCALS
90 100 110 120 130 140
100 110 120 130 140 150
pF1KB7 FCQEIEYWGINELFIDSCCSNRYQERKEENHEKDWDQKSHDVSTDSSFEESSLFEKELEK
: .:. :::: : .:.::. :: .. :: : ... .: . :: ..: :
XP_011 FQEELLYWGIAEDHLDGCCKRRYLQKIEEFAEM-VEREEEDDALDSEGRDS-----EGPA
150 160 170 180 190 200
160 170 180 190 200 210
pF1KB7 FDTLRFGQLRKKIWIRMENPAYCLSAKLIAISSLSVVLASIVAMCVHSMSEFQNED--GE
:.:. ... .: : : .:..: :. : .. : . : .. ...:. :.
XP_011 EGEGRLGRCMRRLRDMVERPHSGLPGKVFACLSVLFVTVTAVNLSVSTLPSLREEEEQGH
210 220 230 240 250 260
220 230 240 250 260 270
pF1KB7 VDDPV--LEGVEIACIAWFTGELAVRLAAAPCQKKFWKNPLNIIDFVSIIPFYATLAVDT
.. . :: .:..::. :. .:: :: . : ..::..::.:.:.:.: :: ::
XP_011 CSQMCHNVFIVESVCVGWFSLEFLLRLIQAPSKFAFLRSPLTLIDLVAILPYYITLLVDG
270 280 290 300 310 320
280 290 300 310 320
pF1KB7 KEEESED-------IENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRHSYHEVGLL
. ....: :...:: .::. ...:::::.::..:: : :. .: :::
XP_011 AAAGRRKPGAGNSYLDKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTARRCTREFGLL
330 340 350 360 370 380
330 340 350 360 370 380
pF1KB7 LLFLSVGISIFSVLIYSVEKDDHTSS-LTSIPICWWWATISMTTVGYGDTHPVTLAGKLI
:::: :.:..:. :.: .:.. : .:::: :.:::.:.:::::::: : . :...
XP_011 LLFLCVAIALFAPLLYVIENEMADSPEFTSIPACYWWAVITMTTVGYGDMVPRSTPGQVV
390 400 410 420 430 440
390 400 410 420 430 440
pF1KB7 ASTCIICGILVVALPITIIFNKFSKYYQKQKDIDVDQCSEDAPEKCHELPYFNIRDIYAQ
: . :. :::..:.:.: ::. ::. : . :
XP_011 ALSSILSGILLMAFPVTSIFHTFSRSYLELKQEQERVMFRRAQFLIKTKSQLSVSQDSDI
450 460 470 480 490 500
450 460 470 480 490
pF1KB7 RMHAFITSLSSVGIVVSDPDSTDASSIEDNEDICNTTSLENCTAK
XP_011 LFGSASSDTRDNN
510
>>XP_011527108 (OMIM: 603788) PREDICTED: potassium volta (513 aa)
initn: 981 init1: 381 opt: 965 Z-score: 991.0 bits: 192.9 E(85289): 1.8e-48
Smith-Waterman score: 965; 38.0% identity (68.2% similar) in 421 aa overlap (9-417:57-471)
10 20 30
pF1KB7 MVFGEFFHRPGQDEELVNLNVGGFKQSVDQSTLLRFPH
.: . .. . .::::.: :. .:: .::
XP_011 AFLPQRQAIKGAFYRRAQRLRPQDEPRQGCQPEDRRRRIIINVGGIKYSLPWTTLDEFPL
30 40 50 60 70 80
40 50 60 70 80 90
pF1KB7 TRLGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCVFS
::::.: .: . . ::..::::.:. .:..:::::. : .:.: .:::....:.:..:
XP_011 TRLGQLKACTNFDDILNVCDDYDVTCNEFFFDRNPGAFGTILTFLRAGKLRLLREMCALS
90 100 110 120 130 140
100 110 120 130 140 150
pF1KB7 FCQEIEYWGINELFIDSCCSNRYQERKEENHEKDWDQKSHDVSTDSSFEESSLFEKELEK
: .:. :::: : .:.::. :: .. :: : ... .: . :: ..: :
XP_011 FQEELLYWGIAEDHLDGCCKRRYLQKIEEFAEM-VEREEEDDALDSEGRDS-----EGPA
150 160 170 180 190 200
160 170 180 190 200 210
pF1KB7 FDTLRFGQLRKKIWIRMENPAYCLSAKLIAISSLSVVLASIVAMCVHSMSEFQNED--GE
:.:. ... .: : : .:..: :. : .. : . : .. ...:. :.
XP_011 EGEGRLGRCMRRLRDMVERPHSGLPGKVFACLSVLFVTVTAVNLSVSTLPSLREEEEQGH
210 220 230 240 250 260
220 230 240 250 260 270
pF1KB7 VDDPV--LEGVEIACIAWFTGELAVRLAAAPCQKKFWKNPLNIIDFVSIIPFYATLAVDT
.. . :: .:..::. :. .:: :: . : ..::..::.:.:.:.: :: ::
XP_011 CSQMCHNVFIVESVCVGWFSLEFLLRLIQAPSKFAFLRSPLTLIDLVAILPYYITLLVDG
270 280 290 300 310 320
280 290 300 310 320
pF1KB7 KEEESED-------IENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRHSYHEVGLL
. ....: :...:: .::. ...:::::.::..:: : :. .: :::
XP_011 AAAGRRKPGAGNSYLDKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTARRCTREFGLL
330 340 350 360 370 380
330 340 350 360 370 380
pF1KB7 LLFLSVGISIFSVLIYSVEKDDHTSS-LTSIPICWWWATISMTTVGYGDTHPVTLAGKLI
:::: :.:..:. :.: .:.. : .:::: :.:::.:.:::::::: : . :...
XP_011 LLFLCVAIALFAPLLYVIENEMADSPEFTSIPACYWWAVITMTTVGYGDMVPRSTPGQVV
390 400 410 420 430 440
390 400 410 420 430 440
pF1KB7 ASTCIICGILVVALPITIIFNKFSKYYQKQKDIDVDQCSEDAPEKCHELPYFNIRDIYAQ
: . :. :::..:.:.: ::. ::. : . :
XP_011 ALSSILSGILLMAFPVTSIFHTFSRSYLELKQEQERVMFRRAQFLIKTKSQLSVSQDSDI
450 460 470 480 490 500
450 460 470 480 490
pF1KB7 RMHAFITSLSSVGIVVSDPDSTDASSIEDNEDICNTTSLENCTAK
XP_011 LFGSASSDTRDNN
510
>>XP_011527102 (OMIM: 603788) PREDICTED: potassium volta (513 aa)
initn: 981 init1: 381 opt: 965 Z-score: 991.0 bits: 192.9 E(85289): 1.8e-48
Smith-Waterman score: 965; 38.0% identity (68.2% similar) in 421 aa overlap (9-417:57-471)
10 20 30
pF1KB7 MVFGEFFHRPGQDEELVNLNVGGFKQSVDQSTLLRFPH
.: . .. . .::::.: :. .:: .::
XP_011 AFLPQRQAIKGAFYRRAQRLRPQDEPRQGCQPEDRRRRIIINVGGIKYSLPWTTLDEFPL
30 40 50 60 70 80
40 50 60 70 80 90
pF1KB7 TRLGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCVFS
::::.: .: . . ::..::::.:. .:..:::::. : .:.: .:::....:.:..:
XP_011 TRLGQLKACTNFDDILNVCDDYDVTCNEFFFDRNPGAFGTILTFLRAGKLRLLREMCALS
90 100 110 120 130 140
100 110 120 130 140 150
pF1KB7 FCQEIEYWGINELFIDSCCSNRYQERKEENHEKDWDQKSHDVSTDSSFEESSLFEKELEK
: .:. :::: : .:.::. :: .. :: : ... .: . :: ..: :
XP_011 FQEELLYWGIAEDHLDGCCKRRYLQKIEEFAEM-VEREEEDDALDSEGRDS-----EGPA
150 160 170 180 190 200
160 170 180 190 200 210
pF1KB7 FDTLRFGQLRKKIWIRMENPAYCLSAKLIAISSLSVVLASIVAMCVHSMSEFQNED--GE
:.:. ... .: : : .:..: :. : .. : . : .. ...:. :.
XP_011 EGEGRLGRCMRRLRDMVERPHSGLPGKVFACLSVLFVTVTAVNLSVSTLPSLREEEEQGH
210 220 230 240 250 260
220 230 240 250 260 270
pF1KB7 VDDPV--LEGVEIACIAWFTGELAVRLAAAPCQKKFWKNPLNIIDFVSIIPFYATLAVDT
.. . :: .:..::. :. .:: :: . : ..::..::.:.:.:.: :: ::
XP_011 CSQMCHNVFIVESVCVGWFSLEFLLRLIQAPSKFAFLRSPLTLIDLVAILPYYITLLVDG
270 280 290 300 310 320
280 290 300 310 320
pF1KB7 KEEESED-------IENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRHSYHEVGLL
. ....: :...:: .::. ...:::::.::..:: : :. .: :::
XP_011 AAAGRRKPGAGNSYLDKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTARRCTREFGLL
330 340 350 360 370 380
330 340 350 360 370 380
pF1KB7 LLFLSVGISIFSVLIYSVEKDDHTSS-LTSIPICWWWATISMTTVGYGDTHPVTLAGKLI
:::: :.:..:. :.: .:.. : .:::: :.:::.:.:::::::: : . :...
XP_011 LLFLCVAIALFAPLLYVIENEMADSPEFTSIPACYWWAVITMTTVGYGDMVPRSTPGQVV
390 400 410 420 430 440
390 400 410 420 430 440
pF1KB7 ASTCIICGILVVALPITIIFNKFSKYYQKQKDIDVDQCSEDAPEKCHELPYFNIRDIYAQ
: . :. :::..:.:.: ::. ::. : . :
XP_011 ALSSILSGILLMAFPVTSIFHTFSRSYLELKQEQERVMFRRAQFLIKTKSQLSVSQDSDI
450 460 470 480 490 500
450 460 470 480 490
pF1KB7 RMHAFITSLSSVGIVVSDPDSTDASSIEDNEDICNTTSLENCTAK
XP_011 LFGSASSDTRDNN
510
491 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 05:35:36 2016 done: Fri Nov 4 05:35:37 2016
Total Scan time: 7.670 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]