FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7176, 365 aa 1>>>pF1KB7176 365 - 365 aa - 365 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.2082+/-0.000332; mu= -3.7959+/- 0.021 mean_var=353.1492+/-73.511, 0's: 0 Z-trim(125.5): 78 B-trim: 822 in 1/61 Lambda= 0.068249 statistics sampled from 49250 (49402) to 49250 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.844), E-opt: 0.2 (0.579), width: 16 Scan time: 8.860 The best scores are: opt bits E(85289) NP_003914 (OMIM: 603621) forkhead box protein H1 [ ( 365) 2648 273.8 4.3e-73 NP_036318 (OMIM: 107250,601094,610256) forkhead bo ( 319) 426 55.0 2.8e-07 NP_001443 (OMIM: 603250) forkhead box protein F2 [ ( 444) 412 53.7 9.2e-07 NP_001444 (OMIM: 601090,601631,602482) forkhead bo ( 553) 405 53.1 1.7e-06 XP_016876735 (OMIM: 602294) PREDICTED: hepatocyte ( 439) 379 50.5 8.7e-06 NP_004487 (OMIM: 602294) hepatocyte nuclear factor ( 472) 379 50.5 9.1e-06 NP_001442 (OMIM: 265380,601089) forkhead box prote ( 379) 364 48.9 2.2e-05 NP_004465 (OMIM: 602211) forkhead box protein D2 [ ( 495) 365 49.2 2.5e-05 NP_150285 (OMIM: 612788) forkhead box protein Q1 [ ( 403) 361 48.7 2.8e-05 NP_004464 (OMIM: 241850,602617,616534) forkhead bo ( 373) 357 48.2 3.5e-05 NP_004463 (OMIM: 601091) forkhead box protein D1 [ ( 465) 353 48.0 5.3e-05 NP_004109 (OMIM: 602939) forkhead box protein S1 [ ( 330) 347 47.2 6.3e-05 NP_004488 (OMIM: 602295) hepatocyte nuclear factor ( 350) 346 47.1 7e-05 NP_710141 (OMIM: 600288) hepatocyte nuclear factor ( 457) 326 45.3 0.00033 NP_068556 (OMIM: 600288) hepatocyte nuclear factor ( 463) 326 45.3 0.00033 NP_001129121 (OMIM: 612351) forkhead box protein I ( 420) 323 45.0 0.00038 NP_005242 (OMIM: 153400,602402) forkhead box prote ( 501) 323 45.0 0.00043 NP_005240 (OMIM: 164874,613454) forkhead box prote ( 489) 318 44.5 0.0006 NP_036320 (OMIM: 274600,600791,601093) forkhead bo ( 378) 315 44.1 0.00062 NP_954586 (OMIM: 611086) forkhead box protein D4-l ( 417) 316 44.3 0.00062 XP_011513493 (OMIM: 616302) PREDICTED: forkhead bo ( 570) 319 44.7 0.00062 NP_005241 (OMIM: 603252) forkhead box protein L1 [ ( 345) 313 43.9 0.00066 NP_954714 (OMIM: 611085) forkhead box protein D4-l ( 416) 314 44.1 0.00071 NP_997188 (OMIM: 601092) forkhead box protein D4 [ ( 439) 314 44.1 0.00073 NP_001032242 (OMIM: 616302) forkhead box protein K ( 733) 319 44.8 0.00074 NP_001445 (OMIM: 602291) forkhead box protein J1 [ ( 421) 311 43.8 0.00087 NP_036316 (OMIM: 611084) forkhead box protein D4-l ( 408) 309 43.6 0.00098 NP_036315 (OMIM: 607836,611539) forkhead box prote ( 478) 309 43.6 0.0011 NP_004505 (OMIM: 147685) forkhead box protein K2 [ ( 660) 310 43.9 0.0013 NP_075555 (OMIM: 110100,605597,608996) forkhead bo ( 376) 303 42.9 0.0014 XP_016856182 (OMIM: 616035) PREDICTED: forkhead bo ( 573) 290 41.8 0.0045 NP_001185781 (OMIM: 616035) forkhead box protein J ( 588) 290 41.9 0.0046 XP_006710522 (OMIM: 616035) PREDICTED: forkhead bo ( 596) 290 41.9 0.0047 XP_006710521 (OMIM: 616035) PREDICTED: forkhead bo ( 607) 290 41.9 0.0047 XP_011539328 (OMIM: 616035) PREDICTED: forkhead bo ( 622) 290 41.9 0.0048 NP_055762 (OMIM: 616035) forkhead box protein J3 i ( 622) 290 41.9 0.0048 NP_001185780 (OMIM: 616035) forkhead box protein J ( 622) 290 41.9 0.0048 NP_001185779 (OMIM: 616035) forkhead box protein J ( 622) 290 41.9 0.0048 XP_005270689 (OMIM: 616035) PREDICTED: forkhead bo ( 630) 290 41.9 0.0048 NP_658982 (OMIM: 274600,600791,601093) forkhead bo ( 283) 276 40.2 0.0072 >>NP_003914 (OMIM: 603621) forkhead box protein H1 [Homo (365 aa) initn: 2648 init1: 2648 opt: 2648 Z-score: 1433.3 bits: 273.8 E(85289): 4.3e-73 Smith-Waterman score: 2648; 100.0% identity (100.0% similar) in 365 aa overlap (1-365:1-365) 10 20 30 40 50 60 pF1KB7 MGPCSGSRLGPPEAESPSQPPKRRKKRYLRHDKPPYTYLAMIALVIQAAPSRRLKLAQII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MGPCSGSRLGPPEAESPSQPPKRRKKRYLRHDKPPYTYLAMIALVIQAAPSRRLKLAQII 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 RQVQAVFPFFREDYEGWKDSIRHNLSSNRCFRKVPKDPAKPQAKGNFWAVDVSLIPAEAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RQVQAVFPFFREDYEGWKDSIRHNLSSNRCFRKVPKDPAKPQAKGNFWAVDVSLIPAEAL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 RLQNTALCRRWQNGGARGAFAKDLGPYVLHGRPYRPPSPPPPPSEGFSIKSLLGGSGEGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RLQNTALCRRWQNGGARGAFAKDLGPYVLHGRPYRPPSPPPPPSEGFSIKSLLGGSGEGA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 PWPGLAPQSSPVPAGTGNSGEEAVPTPPLPSSERPLWPLCPLPGPTRVEGETVQGGAIGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 PWPGLAPQSSPVPAGTGNSGEEAVPTPPLPSSERPLWPLCPLPGPTRVEGETVQGGAIGP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 STLSPEPRAWPLHLLQGTAVPGGRSSGGHRASLWGQLPTSYLPIYTPNVVMPLAPPPTSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 STLSPEPRAWPLHLLQGTAVPGGRSSGGHRASLWGQLPTSYLPIYTPNVVMPLAPPPTSC 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 PQCPSTSPAYWGVAPETRGPPGLLCDLDALFQGVPPNKSIYDVWVSHPRDLAAPGPGWLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 PQCPSTSPAYWGVAPETRGPPGLLCDLDALFQGVPPNKSIYDVWVSHPRDLAAPGPGWLL 310 320 330 340 350 360 pF1KB7 SWCSL ::::: NP_003 SWCSL >>NP_036318 (OMIM: 107250,601094,610256) forkhead box pr (319 aa) initn: 384 init1: 314 opt: 426 Z-score: 251.6 bits: 55.0 E(85289): 2.8e-07 Smith-Waterman score: 458; 37.3% identity (59.2% similar) in 260 aa overlap (14-245:52-301) 10 20 30 40 pF1KB7 MGPCSGSRLGPPEAESPSQPPKRRKKRYLRHDKPPYTYLAMIA : .:. : ::..: :.. ::::.:.:.:: NP_036 VAPSGPPPSPLAGAEPGREPEEAAAGRGEAAPTPAPGPGRRRRRPLQRGKPPYSYIALIA 30 40 50 60 70 80 50 60 70 80 90 100 pF1KB7 LVIQAAPSRRLKLAQIIRQVQAVFPFFREDYEGWKDSIRHNLSSNRCFRKVPKDPAKPQA ... ::.::: :: : : . : :.:.. . :..::::::. : :: :::..:..: . NP_036 MALAHAPGRRLTLAAIYRFITERFAFYRDSPRKWQNSIRHNLTLNDCFVKVPREPGNP-G 90 100 110 120 130 140 110 120 130 140 150 pF1KB7 KGNFWAVDVSLIPAEALRLQNTALCRRWQ-----NGGARGAFAKDLGPYVLHGRPYRP-P :::.:..: :: : ..: .. :: . . :..: : : . :: : : NP_036 KGNYWTLD----PAAADMFDNGSFLRRRKRFKRAELPAHAAAAPG-PPLPFPYAPYAPAP 150 160 170 180 190 160 170 180 190 200 pF1KB7 SPP---PPPSEG---------FSIKSLLGG----SGEGAPWPGLAPQSSPVPAGTGNSGE .: :::: : ::. ::.. .: ::: : ..: :... NP_036 GPALLVPPPSAGPGPSPPARLFSVDSLVNLQPELAGLGAPEPPCC--AAPDAAAAAFPPC 200 210 220 230 240 250 210 220 230 240 250 pF1KB7 EAVPTPPLPSS--ERPLWPLC-PLPGPTRVEGETVQGG---AIGPSTLSPEPRAWPLHLL :. .::: :. .: . : : ::: .: . .: :.:: ::: NP_036 AAAASPPLYSQVPDRLVLPATRPGPGPLPAEPLLALAGPAAALGP--LSPGEAYLRQPGF 260 270 280 290 300 310 260 270 280 290 300 310 pF1KB7 QGTAVPGGRSSGGHRASLWGQLPTSYLPIYTPNVVMPLAPPPTSCPQCPSTSPAYWGVAP NP_036 ASGLERYL >>NP_001443 (OMIM: 603250) forkhead box protein F2 [Homo (444 aa) initn: 361 init1: 303 opt: 412 Z-score: 242.4 bits: 53.7 E(85289): 9.2e-07 Smith-Waterman score: 412; 32.9% identity (54.9% similar) in 304 aa overlap (10-301:77-361) 10 20 30 pF1KB7 MGPCSGSRLGPPEAESPSQPPKRRKKRYLRHDKPPYTYL : : . : :. .. : .::::.:. NP_001 SSSSSSSASCASSSSSSNSASAPSAACKSAGGGGAGAGSGGAKKASSGLRRPEKPPYSYI 50 60 70 80 90 100 40 50 60 70 80 90 pF1KB7 AMIALVIQAAPSRRLKLAQIIRQVQAVFPFFREDYEGWKDSIRHNLSSNRCFRKVPKDPA :.:...::..::.:: :..: . .:: ::::: :.:::.:.::::: :.:: :.:: . NP_001 ALIVMAIQSSPSKRLTLSEIYQFLQARFPFFRGAYQGWKNSVRHNLSLNECFIKLPKGLG 110 120 130 140 150 160 100 110 120 130 140 150 pF1KB7 KPQAKGNFWAVDVSLIPAEALRLQNTALCRRWQNGGARGAFA-KDLGPYVLHGRPYRPPS .: .::..:..: :: . ... .. :: : : : : . :. : . NP_001 RP-GKGHYWTID----PASEFMFEEGSF-RRRPRGFRRKCQALKPMYHRVVSGLGFGASL 170 180 190 200 210 220 160 170 180 190 200 210 pF1KB7 PPP------PPSEGFSIKSLLGGSG-EGAPWPGLAPQSSPVPAGTGNSGEEAVP-TPPLP : ::: .. .: : .: . : : ..: : . .. :: : : NP_001 LPQGFDFQAPPSAPLGCHSQGGYGGLDMMPAGYDAGAGAPSHAHPHHHHHHHVPHMSPNP 230 240 250 260 270 280 220 230 240 250 260 pF1KB7 SSERPLWPLCPLP-GPTRVEGETVQGGA-IGP-STLSPEPRAWPLHLLQGTAVPGGRSSG .: ::.: :: : . ::. :: :. :: : . : ...:. .: NP_001 GST--YMASCPVPAGPGGVGAAGGGGGGDYGPDSSSSPVPSS-PA---MASAIEC-HSPY 290 300 310 320 330 270 280 290 300 310 320 pF1KB7 GHRASLWGQLPTSYLPIYTPNVVMPLAPPPTSCPQCPSTSPAYWGVAPETRGPPGLLCDL :. :.. : .: . .: : :.: : NP_001 TSPAAHWSS------PGASPYLKQPPALTPSSNPAASAGLHSSMSSYSLEQSYLHQNARE 340 350 360 370 380 330 340 350 360 pF1KB7 DALFQGVPPNKSIYDVWVSHPRDLAAPGPGWLLSWCSL NP_001 DLSVGLPRYQHHSTPVCDRKDFVLNFNGISSFHPSASGSYYHHHHQSVCQDIKPCVM 390 400 410 420 430 440 >>NP_001444 (OMIM: 601090,601631,602482) forkhead box pr (553 aa) initn: 366 init1: 277 opt: 405 Z-score: 237.5 bits: 53.1 E(85289): 1.7e-06 Smith-Waterman score: 409; 31.1% identity (52.2% similar) in 322 aa overlap (10-310:59-361) 10 20 30 pF1KB7 MGPCSGSRLGPPEAESPSQPPKRRKKRYLRHDKPPYTYL : .: .: : . : ::::.:. NP_001 AAAAAGGGYTAMPAPMSVYSHPAHAEQYPGGMARAYGPYTPQPQPKDMV----KPPYSYI 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB7 AMIALVIQAAPSRRLKLAQIIRQVQAVFPFFREDYEGWKDSIRHNLSSNRCFRKVPKDPA :.:...:: ::.... : : . .. :::.:.. .::..::::::: :.:: :::.: NP_001 ALITMAIQNAPDKKITLNGIYQFIMDRFPFYRDNKQGWQNSIRHNLSLNECFVKVPRDDK 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB7 KPQAKGNFWAVDVSLIPAEALRLQNTALCRRWQNGGARGAFAKDLGPYVLHGR----PYR :: .::..:..: : ..: .. :: . . : :: . : : NP_001 KP-GKGSYWTLD----PDSYNMFENGSFLRRRRRFKKKDAVKDKEEKDRLHLKEPPPPGR 150 160 170 180 190 160 170 180 190 200 pF1KB7 --PPSPP-----------PPPSEGFSIKSLLGGSGEGAPWPGLAPQSSPVPAGTGNSGEE ::.:: ::: . .::. .:. . : : :.: :. :... NP_001 QPPPAPPEQADGNAPGPQPPPVRIQDIKTE-NGTCPSPPQP-LSPA-----AALGSGSAA 200 210 220 230 240 250 210 220 230 240 250 pF1KB7 AVPTPPLP-SSERPLWPLCPLPG--PTRVEGETVQGGAIGPSTLSPEPRAWPLHLLQGTA ::: : :: : :: :. .. ...:. .: : : : : : :: . NP_001 AVPKIESPDSSSSSLSSGSSPPGSLPS-ARPLSLDGADSAPP--PPAPSAPPPHHSQGFS 260 270 280 290 300 260 270 280 290 300 310 pF1KB7 VPGGRSS-GGHRASLWGQLPTSYLPIYTPNVVMPLAPPPTSCPQCPSTSPAYWGVAPETR : . .: : : ..: .. : . . .::: . :. : : NP_001 VDNIMTSLRGSPQSAAAELSSGLLASAAASSRAGIAPPLALGAYSPGQSSLYSSPCSQTS 310 320 330 340 350 360 320 330 340 350 360 pF1KB7 GPPGLLCDLDALFQGVPPNKSIYDVWVSHPRDLAAPGPGWLLSWCSL NP_001 SAGSSGGGGGGAGAAGGAGGAGTYHCNLQAMSLYAAGERGGHLQGAPGGAGGSAVDDPLP 370 380 390 400 410 420 >>XP_016876735 (OMIM: 602294) PREDICTED: hepatocyte nucl (439 aa) initn: 351 init1: 273 opt: 379 Z-score: 224.9 bits: 50.5 E(85289): 8.7e-06 Smith-Waterman score: 384; 33.3% identity (56.1% similar) in 246 aa overlap (1-224:101-332) 10 20 pF1KB7 MGPCSGSRLGPPEAESPSQPPKRRK----- :.:: . : : .::. . : XP_016 MGTALSPSGMGAMGAQQAASMNGLGPYAAAMNPCMS-----PMAYAPSNLGRSRAGGGGD 80 90 100 110 120 30 40 50 60 70 80 pF1KB7 ----KRYLRHDKPPYTYLAMIALVIQAAPSRRLKLAQIIRQVQAVFPFFREDYEGWKDSI :: : ::::.:...:...:: :::. : :..: . .. .::..:.. . :..:: XP_016 AKTFKRSYPHAKPPYSYISLITMAIQQAPSKMLTLSEIYQWIMDLFPYYRQNQQRWQNSI 130 140 150 160 170 180 90 100 110 120 130 pF1KB7 RHNLSSNRCFRKVPKDPAKPQAKGNFWAVDVSLIPAEALRLQNTALCRRWQ------NGG ::.:: : :: :: ..: :: .::..: .: : . ..: :: . . : XP_016 RHSLSFNDCFVKVARSPDKP-GKGSYW----TLHPDSGNMFENGCYLRRQKRFKCEKQPG 190 200 210 220 230 240 140 150 160 170 180 pF1KB7 ARGAFAKDLGPYVLHGRP--YRPPSPPPPPSEGFSI-KSLLGGSG--EGAPWPGLA--PQ : :. .. : .: : . :: :: . ... : .: :::: :: : :: XP_016 AGGGGGSGSGGSGAKGGPESRKDPSGASNPSADSPLHRGVHGKTGQLEGAPAPGPAASPQ 250 260 270 280 290 300 190 200 210 220 230 240 pF1KB7 SSPVPAGTGNSGEEAVPTPPLPSSERPLWPLCPLPGPTRVEGETVQGGAIGPSTLSPEPR . ..:...: . :: :: : :. :: XP_016 TLDHSGATATGGASELKTPA--SSTAP--PISSGPGALASVPASHPAHGLAPHESQLHLK 310 320 330 340 350 250 260 270 280 290 300 pF1KB7 AWPLHLLQGTAVPGGRSSGGHRASLWGQLPTSYLPIYTPNVVMPLAPPPTSCPQCPSTSP XP_016 GDPHYSFNHPFSINNLMSSSEQQHKLDFKAYEQALQYSPYGSTLPASLPLGSASVTTRSP 360 370 380 390 400 410 >>NP_004487 (OMIM: 602294) hepatocyte nuclear factor 3-a (472 aa) initn: 351 init1: 273 opt: 379 Z-score: 224.5 bits: 50.5 E(85289): 9.1e-06 Smith-Waterman score: 384; 33.3% identity (56.1% similar) in 246 aa overlap (1-224:134-365) 10 20 pF1KB7 MGPCSGSRLGPPEAESPSQPPKRRK----- :.:: . : : .::. . : NP_004 MGTALSPSGMGAMGAQQAASMNGLGPYAAAMNPCMS-----PMAYAPSNLGRSRAGGGGD 110 120 130 140 150 30 40 50 60 70 80 pF1KB7 ----KRYLRHDKPPYTYLAMIALVIQAAPSRRLKLAQIIRQVQAVFPFFREDYEGWKDSI :: : ::::.:...:...:: :::. : :..: . .. .::..:.. . :..:: NP_004 AKTFKRSYPHAKPPYSYISLITMAIQQAPSKMLTLSEIYQWIMDLFPYYRQNQQRWQNSI 160 170 180 190 200 210 90 100 110 120 130 pF1KB7 RHNLSSNRCFRKVPKDPAKPQAKGNFWAVDVSLIPAEALRLQNTALCRRWQ------NGG ::.:: : :: :: ..: :: .::..: .: : . ..: :: . . : NP_004 RHSLSFNDCFVKVARSPDKP-GKGSYW----TLHPDSGNMFENGCYLRRQKRFKCEKQPG 220 230 240 250 260 270 140 150 160 170 180 pF1KB7 ARGAFAKDLGPYVLHGRP--YRPPSPPPPPSEGFSI-KSLLGGSG--EGAPWPGLA--PQ : :. .. : .: : . :: :: . ... : .: :::: :: : :: NP_004 AGGGGGSGSGGSGAKGGPESRKDPSGASNPSADSPLHRGVHGKTGQLEGAPAPGPAASPQ 280 290 300 310 320 330 190 200 210 220 230 240 pF1KB7 SSPVPAGTGNSGEEAVPTPPLPSSERPLWPLCPLPGPTRVEGETVQGGAIGPSTLSPEPR . ..:...: . :: :: : :. :: NP_004 TLDHSGATATGGASELKTPA--SSTAP--PISSGPGALASVPASHPAHGLAPHESQLHLK 340 350 360 370 380 250 260 270 280 290 300 pF1KB7 AWPLHLLQGTAVPGGRSSGGHRASLWGQLPTSYLPIYTPNVVMPLAPPPTSCPQCPSTSP NP_004 GDPHYSFNHPFSINNLMSSSEQQHKLDFKAYEQALQYSPYGSTLPASLPLGSASVTTRSP 390 400 410 420 430 440 >>NP_001442 (OMIM: 265380,601089) forkhead box protein F (379 aa) initn: 333 init1: 290 opt: 364 Z-score: 217.7 bits: 48.9 E(85289): 2.2e-05 Smith-Waterman score: 389; 29.2% identity (53.7% similar) in 322 aa overlap (2-305:18-337) 10 20 30 40 pF1KB7 MGPCSGSRLGPPEAESPSQPPKRRKKRYLRHDKPPYTYLAMIAL : .:. : . .::. :. . : .::::.:.:.:.. NP_001 MSSAPEKQQPPHGGGGGGGGGGGAAMDPASSGPSKA-KKTNAGIRRPEKPPYSYIALIVM 10 20 30 40 50 50 60 70 80 90 100 pF1KB7 VIQAAPSRRLKLAQIIRQVQAVFPFFREDYEGWKDSIRHNLSSNRCFRKVPKDPAKPQAK .::..:..:: :..: . .:. ::::: .:.:::.:.::::: :.:: :.:: ..: .: NP_001 AIQSSPTKRLTLSEIYQFLQSRFPFFRGSYQGWKNSVRHNLSLNECFIKLPKGLGRP-GK 60 70 80 90 100 110 110 120 130 140 150 pF1KB7 GNFWAVDVS---LIPAEALRLQNTALCRRWQNGGARGAFAKDLG----P--YVLHGRPYR :..:..: . .. ..: . .. :. : .. . :: : : ..: NP_001 GHYWTIDPASEFMFEEGSFRRRPRGFRRKCQALKPMYSMMNGLGFNHLPDTYGFQGSAGG 120 130 140 150 160 170 160 170 180 190 200 pF1KB7 PPSPPPPPS-EGF--SIKSLLGGSGEGAPWPGLAPQSSPVPAG---TGNSGEEAVPTPPL :: . :: ... : :. .: :. . : .: :. : :. : NP_001 LSCPPNSLALEGGLGMMNGHLPGNVDGMALPSHSVPHLPSNGGHSYMGGCGGAAAGEYPH 180 190 200 210 220 230 210 220 230 240 250 260 pF1KB7 PSSERPLWPLCPLPGPTRVEGETVQGG--AIGPSTLSPEPRAWPLHLLQGTAVPGGRSSG .: : :: : . .: ..: .: : : . : . .. : : . ... NP_001 HDSSVPASPLLPTGAGGVMEPHAVYSGSAAAWPPSASAALNSGASYIKQQPLSPCNPAAN 240 250 260 270 280 290 270 280 290 300 310 320 pF1KB7 GHRASLWGQ-LPTSYLPIYTPNVVMPLAPPPTSCPQCPSTSPAYWGVAPETRGPPGLLCD .:: . : :: . :. : : : :: NP_001 PLSGSLSTHSLEQPYLHQNSHNAPAELQGIPRYHSQSPSMCDRKEFVFSFNAMASSSMHS 300 310 320 330 340 350 330 340 350 360 pF1KB7 LDALFQGVPPNKSIYDVWVSHPRDLAAPGPGWLLSWCSL NP_001 AGGGSYYHQQVTYQDIKPCVM 360 370 >>NP_004465 (OMIM: 602211) forkhead box protein D2 [Homo (495 aa) initn: 395 init1: 266 opt: 365 Z-score: 216.8 bits: 49.2 E(85289): 2.5e-05 Smith-Waterman score: 375; 31.0% identity (52.8% similar) in 271 aa overlap (5-254:108-356) 10 20 30 pF1KB7 MGPCSGSRLGPPEAESPSQPPKRRKKRYLRHDKP .: ::: . . .. : :: NP_004 SDGEPRALASRGAAAAAGSPGPGAAAARGAAGPGPGPPSGGAATRSPLV---------KP 80 90 100 110 120 40 50 60 70 80 90 pF1KB7 PYTYLAMIALVIQAAPSRRLKLAQIIRQVQAVFPFFREDYEGWKDSIRHNLSSNRCFRKV ::.:.:.:...: .:..:: :..: . ... ::..:: . .:..::::::: : :: :. NP_004 PYSYIALITMAILQSPKKRLTLSEICEFISGRFPYYREKFPAWQNSIRHNLSLNDCFVKI 130 140 150 160 170 180 100 110 120 130 140 150 pF1KB7 PKDPAKPQAKGNFWAVDVSLIPAEALRLQNTALCRRWQNGGARGAFAKD-LGPYVLHGRP :..:..: .:::.:..: : : ..: .. :: : : .. : : : .: NP_004 PREPGNP-GKGNYWTLD----PESADMFDNGSFLRR------RKRFKRQPLPPPHPHPHP 190 200 210 220 230 160 170 180 190 pF1KB7 Y---------RPPSPPPPPSEGFSIKSLLG-GSG-----EGAPWPGLAPQSSPVPAGTGN . . : ::. . : : : ::: :: ::. : : . . NP_004 HPELLLRGGAAAAGDPGAFLPGFAAYGAYGYGYGLALPAYGAPPPGPAPHPHPHPHAFAF 240 250 260 270 280 290 200 210 220 230 240 250 pF1KB7 SGEEAVPTPPLPSSERPLWPLCPLPGPTRVEGETVQGGAIGPSTLS-----PEPRAWPLH .. :. . : : : : ::: . . :.: .:. : : : . : NP_004 AA--AAAAAPCQLSVPPGRAAAPPPGPPTASVFAGAGSAPAPAPASGSGPGPGPAGLPAF 300 310 320 330 340 350 260 270 280 290 300 310 pF1KB7 LLQGTAVPGGRSSGGHRASLWGQLPTSYLPIYTPNVVMPLAPPPTSCPQCPSTSPAYWGV : NP_004 LGAELGCAKAFYAASLSPPAAGTAAGLPTALLRQGLKTDAGGGAGGGGAGAGQRPSFSID 360 370 380 390 400 410 >>NP_150285 (OMIM: 612788) forkhead box protein Q1 [Homo (403 aa) initn: 352 init1: 323 opt: 361 Z-score: 215.8 bits: 48.7 E(85289): 2.8e-05 Smith-Waterman score: 398; 32.0% identity (54.0% similar) in 278 aa overlap (12-262:98-369) 10 20 30 40 pF1KB7 MGPCSGSRLGPPEAESPSQPPKRRKKRYLRHDKPPYTYLAM : : . .. :.: : :. ::::.:.:. NP_150 AGGGPGAEEAIPAAAAAAVVAEGAEAGAAGPGAGGAGSGEGARSKPYTRRPKPPYSYIAL 70 80 90 100 110 120 50 60 70 80 90 100 pF1KB7 IALVIQAAPSRRLKLAQIIRQVQAVFPFFREDYEGWKDSIRHNLSSNRCFRKVPKDPAKP ::..:. . . :: ::.: . ... ::::: .: ::..:.::::: : :: :: .::..: NP_150 IAMAIRDSAGGRLTLAEINEYLMGKFPFFRGSYTGWRNSVRHNLSLNDCFVKVLRDPSRP 130 140 150 160 170 180 110 120 130 140 150 160 pF1KB7 QAKGNFWAVDVSLIPAEALRLQNTALCRRWQNGGARGAF-AKDLGPYVLHGRPYRPPSPP .: :.: .. : . . .. :: . . :. : : : : : :: : NP_150 WGKDNYWMLN----PNSEYTFADGVFRRRRKRLSHRAPVPAPGLRPEEAPGLPAAPPPAP 190 200 210 220 230 240 170 180 190 200 pF1KB7 PPPSEGF---SIKSLLGGSGEGAPWPGLAPQS---SP---------VPAGTGNSGEEAVP :. .. .: : ..: .: .: .:. : . : :.: NP_150 AAPASPRMRSPARQEERASPAGKFSSSFAIDSILRKPFRSRRLRDTAPGTTLQWG--AAP 250 260 270 280 290 300 210 220 230 240 250 pF1KB7 TPPLPSSE--------RPLWPLCPLPG--PTRVEGETVQGGAIGPSTL-SPEPRAWPLHL ::::. : : ::: . :.:. .. .. .: : .: : : : . NP_150 CPPLPAFPALLPAAPCRALLPLCAYGAGEPARLGAREAEVPPTAPPLLLAPLPAAAPAKP 310 320 330 340 350 360 260 270 280 290 300 310 pF1KB7 LQGTAVPGGRSSGGHRASLWGQLPTSYLPIYTPNVVMPLAPPPTSCPQCPSTSPAYWGVA :.: :. : NP_150 LRGPAAGGAHLYCPLRLPAALQAASVRRPGPHLPYPVETLLA 370 380 390 400 >>NP_004464 (OMIM: 241850,602617,616534) forkhead box pr (373 aa) initn: 365 init1: 292 opt: 357 Z-score: 214.1 bits: 48.2 E(85289): 3.5e-05 Smith-Waterman score: 400; 29.9% identity (51.3% similar) in 318 aa overlap (10-320:30-306) 10 20 30 40 pF1KB7 MGPCSGSRLGPPEAESPSQPPKRRKKRYLRHDKPPYTYLA : : . ::.:: :.. ::::.:.: NP_004 MTAESGPPPPQPEVLATVKEERGETAAGAGVPGEATGRGAGGRRRKRPLQRGKPPYSYIA 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB7 MIALVIQAAPSRRLKLAQIIRQVQAVFPFFREDYEGWKDSIRHNLSSNRCFRKVPKDPAK .::..: :: ::: :. : . . :::.:.. . :..::::::. : :: :.:.. .. NP_004 LIAMAIAHAPERRLTLGGIYKFITERFPFYRDNPKKWQNSIRHNLTLNDCFLKIPREAGR 70 80 90 100 110 120 110 120 130 140 150 pF1KB7 PQAKGNFWAVDVSLIPAEALRLQNTALCRRWQNGGARGAFAK-DLGPYVLHGRPYRPPSP : .:::.::.: : ... .. :: : : . ::. : : NP_004 P-GKGNYWALD----PNAEDMFESGSFLRR------RKRFKRSDLSTY-----------P 130 140 150 160 170 180 190 200 210 pF1KB7 PPPPSEGFSIKSLLGGSGEGAPWPGLAPQSSPVPAGTGNSGEEAVPTPPLPSSERPLWPL . . . . .... .: .:: .: . : :. .: .:: .. :.. NP_004 AYMHDAAAAAAAAAAAAAAAAIFPGAVPAARPPYPGAVYAGY----APPSLAAPPPVYYP 160 170 180 190 200 210 220 230 240 250 260 270 pF1KB7 CPLPGPTRVEGETVQGGAIGPSTLSPEPRAWPLHLLQGTAVPGGR---SSGGHRASLWGQ ::: :: : . :::: : .: ::: .:.: :. : NP_004 AASPGPCRVFG------LVPERPLSPELGPAP----SG---PGGSCAFASAGAPATTTGY 220 230 240 250 260 280 290 300 310 320 330 pF1KB7 LP---TSYLPIYTPNVVMPLAPPPTSCPQCPSTSPAYWGVAPETRGPPGLLCDLDALFQG : :. : . : : . :: ... : ...: . :: NP_004 QPAGCTGARPANPSAYAAAYAGPDGAYPQ--GAGSAIFAAAGRLAGPASPPAGGSSGGVE 270 280 290 300 310 340 350 360 pF1KB7 VPPNKSIYDVWVSHPRDLAAPGPGWLLSWCSL NP_004 TTVDFYGRTSPGQFGALGACYNPGGQLGGASAGAYHARHAAAYPGGIDRFVSAM 320 330 340 350 360 370 365 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 05:37:34 2016 done: Fri Nov 4 05:37:35 2016 Total Scan time: 8.860 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]