FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7188, 462 aa 1>>>pF1KB7188 462 - 462 aa - 462 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.5476+/-0.000786; mu= 12.9695+/- 0.048 mean_var=109.4977+/-22.179, 0's: 0 Z-trim(111.1): 6 B-trim: 0 in 0/51 Lambda= 0.122566 statistics sampled from 12094 (12098) to 12094 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.717), E-opt: 0.2 (0.372), width: 16 Scan time: 3.490 The best scores are: opt bits E(32554) CCDS5942.1 SHH gene_id:6469|Hs108|chr7 ( 462) 3084 555.9 3.2e-158 CCDS33380.1 IHH gene_id:3549|Hs108|chr2 ( 411) 1342 247.8 1.5e-65 CCDS8779.1 DHH gene_id:50846|Hs108|chr12 ( 396) 1206 223.8 2.6e-58 >>CCDS5942.1 SHH gene_id:6469|Hs108|chr7 (462 aa) initn: 3084 init1: 3084 opt: 3084 Z-score: 2954.1 bits: 555.9 E(32554): 3.2e-158 Smith-Waterman score: 3084; 100.0% identity (100.0% similar) in 462 aa overlap (1-462:1-462) 10 20 30 40 50 60 pF1KB7 MLLLARCLLLVLVSSLLVCSGLACGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGASG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 MLLLARCLLLVLVSSLLVCSGLACGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGASG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 RYEGKISRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 RYEGKISRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 KLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 KLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 IHCSVKAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLSPGDRVLAADDQGRLLYSDFLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 IHCSVKAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLSPGDRVLAADDQGRLLYSDFLT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 FLDRDDGAKKVFYVIETREPRERLLLTAAHLLFVAPHNDSATGEPEASSGSGPPSGGALG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 FLDRDDGAKKVFYVIETREPRERLLLTAAHLLFVAPHNDSATGEPEASSGSGPPSGGALG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 PRALFASRVRPGQRVYVVAERDGDRRLLPAAVHSVTLSEEAAGAYAPLTAQGTILINRVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 PRALFASRVRPGQRVYVVAERDGDRRLLPAAVHSVTLSEEAAGAYAPLTAQGTILINRVL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 ASCYAVIEEHSWAHRAFAPFRLAHALLAALAPARTDRGGDSGGGDRGGGGGRVALTAPGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 ASCYAVIEEHSWAHRAFAPFRLAHALLAALAPARTDRGGDSGGGDRGGGGGRVALTAPGA 370 380 390 400 410 420 430 440 450 460 pF1KB7 ADAPGAGATAGIHWYSQLLYQIGTWLLDSEALHPLGMAVKSS :::::::::::::::::::::::::::::::::::::::::: CCDS59 ADAPGAGATAGIHWYSQLLYQIGTWLLDSEALHPLGMAVKSS 430 440 450 460 >>CCDS33380.1 IHH gene_id:3549|Hs108|chr2 (411 aa) initn: 1657 init1: 1275 opt: 1342 Z-score: 1290.1 bits: 247.8 E(32554): 1.5e-65 Smith-Waterman score: 1583; 58.9% identity (74.2% similar) in 453 aa overlap (7-458:13-407) 10 20 30 40 50 pF1KB7 MLLLARCLLLVLVSSLLVCSGLACGPGRGFG-KRRHPKKLTPLAYKQFIPNVAE ::.:.:. :.: .. .::::: : .:: :.::.::::::: ::: : CCDS33 MSPARLRPRLHFCLVLLLL--LVVPAAWGCGPGRVVGSRRRPPRKLVPLAYKQFSPNVPE 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 KTLGASGRYEGKISRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISV :::::::::::::.:.:::::::::::::::::::::::::::::::::::.::.::::: CCDS33 KTLGASGRYEGKIARSSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDRLNSLAISV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 MNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWV ::::::::::::::::::::::::::::::::::::::::::.:::.::::::::::::: CCDS33 MNQWPGVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRNKYGLLARLAVEAGFDWV 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB7 YYESKAHIHCSVKAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLSPGDRVLAADDQGRL :::::::.:::::.:.:.:::.:::::..: :.::.:. .. . ::::::: ..: CCDS33 YYESKAHVHCSVKSEHSAAAKTGGCFPAGAQVRLESGARVALSAVRPGDRVLAMGEDGSP 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 LYSDFLTFLDRDDGAKKVFYVIETREPRERLLLTAAHLLFVAPHNDSATGEPEASSGSGP .:: : ::::. ..: ::::..: .:: :: :::::.: :. : :: : CCDS33 TFSDVLIFLDREPHRLRAFQVIETQDPPRRLALTPAHLLFTA---DNHT-EPAARF---- 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB7 PSGGALGPRALFASRVRPGQRVYVVAERDGDRRLLPAAVHSVTLSEEAAGAYAPLTAQGT :: :::.:.::: : .:: : : :: : .:. .. : ::::::: .:: CCDS33 --------RATFASHVQPGQYV-LVAGVPG---LQPARVAAVS-THVALGAYAPLTKHGT 300 310 320 330 360 370 380 390 400 410 pF1KB7 ILINRVLASCYAVIEEHSWAHRAFAPFRLAHALLAALAPARTDRGGDSGGGDRGGGGGRV .... :.:::.:.. .: :. :: :.:: :.: CCDS33 LVVEDVVASCFAAVADHHLAQLAFWPLRLFHSL--------------------------- 340 350 360 370 420 430 440 450 460 pF1KB7 ALTAPGAADAPGAGATAGIHWYSQLLYQIGTWLLDSEALHPLGMAVKSS : :. .:: :.::: ::::..: ::. ..:::::. CCDS33 ---AWGSW-TPGE----GVHWYPQLLYRLGRLLLEEGSFHPLGMSGAGS 380 390 400 410 >>CCDS8779.1 DHH gene_id:50846|Hs108|chr12 (396 aa) initn: 1421 init1: 1126 opt: 1206 Z-score: 1160.4 bits: 223.8 E(32554): 2.6e-58 Smith-Waterman score: 1474; 54.4% identity (72.9% similar) in 450 aa overlap (1-447:1-395) 10 20 30 40 50 pF1KB7 MLLLARCLLLVLVSSLLVCSGLACGPGRG-FGKRRHPKK-LTPLAYKQFIPNVAEKTLGA : ::. : : .. ::. . .:::::: :.::. .: :.:: ::::.:.: :.:::: CCDS87 MALLTNLLPLCCLA-LLALPAQSCGPGRGPVGRRRYARKQLVPLLYKQFVPGVPERTLGA 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 SGRYEGKISRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWP :: ::...:.::::..:.::::::::::::::.:::::::.:::...:::::.:::.:: CCDS87 SGPAEGRVARGSERFRDLVPNYNPDIIFKDEENSGADRLMTERCKERVNALAIAVMNMWP 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 GVKLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESK ::.:::::::::::::...::::::::.:::::::::.:::.:::::::::::::::::. CCDS87 GVRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESR 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB7 AHIHCSVKAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLSPGDRVLAADDQGRLLYSDF :.: ::::.::.:...::::::.:::.: .: : ...: :: ::::: .::.. . CCDS87 NHVHVSVKADNSLAVRAGGCFPGNATVRLWSGERKGLRELHRGDWVLAADASGRVVPTPV 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 LTFLDRDDGAKKVFYVIETREPRERLLLTAAHLLFVAPHNDSATGEPEASSGSGP-PSGG : ::::: . : ..::. : ..:::: ::.:.: :: :. : CCDS87 LLFLDRDLQRRASFVAVETEWPPRKLLLTPWHLVFAA---------------RGPAPAPG 240 250 260 270 280 300 310 320 330 340 350 pF1KB7 ALGPRALFASRVRPGQRVYVVAERDGDRRLLPAAVHSVTLSEEAAGAYAPLTAQGTILIN ..: .:: :.: :. : . : : :: : :. :::.:..:::::.::.:.: CCDS87 DFAP--VFARRLRAGDSVLA----PGGDALRPARVARVA-REEAVGVFAPLTAHGTLLVN 290 300 310 320 330 360 370 380 390 400 410 pF1KB7 RVLASCYAVIEEHSWAHRAFAPFRLAHALLAALAPARTDRGGDSGGGDRGGGGGRVALTA ::::::::.: :.::::::::.:: ::: : : CCDS87 DVLASCYAVLESHQWAHRAFAPLRLLHALGALL--------------------------- 340 350 360 370 420 430 440 450 460 pF1KB7 PGAADAPGAGATAGIHWYSQLLYQIGTWLLDSEALHPLGMAVKSS ::.: : .:.::::.:::... :: CCDS87 PGGAVQP-----TGMHWYSRLLYRLAEELLG 380 390 462 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 05:43:45 2016 done: Fri Nov 4 05:43:45 2016 Total Scan time: 3.490 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]