FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7200, 431 aa 1>>>pF1KB7200 431 - 431 aa - 431 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.9548+/-0.000327; mu= 7.2125+/- 0.021 mean_var=196.1684+/-41.068, 0's: 0 Z-trim(122.2): 146 B-trim: 715 in 1/54 Lambda= 0.091571 statistics sampled from 39737 (39887) to 39737 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.793), E-opt: 0.2 (0.468), width: 16 Scan time: 11.000 The best scores are: opt bits E(85289) NP_054728 (OMIM: 222100,300292,304790) forkhead bo ( 431) 3004 409.0 1.2e-113 XP_016885054 (OMIM: 222100,300292,304790) PREDICTE ( 516) 2407 330.2 7.7e-90 NP_001107849 (OMIM: 222100,300292,304790) forkhead ( 396) 2274 312.5 1.2e-84 XP_016885055 (OMIM: 222100,300292,304790) PREDICTE ( 504) 2274 312.6 1.5e-84 XP_016885056 (OMIM: 222100,300292,304790) PREDICTE ( 473) 1932 267.4 5.6e-71 XP_011542218 (OMIM: 222100,300292,304790) PREDICTE ( 564) 1932 267.4 6.4e-71 XP_006724596 (OMIM: 222100,300292,304790) PREDICTE ( 454) 1783 247.7 4.6e-65 XP_011512593 (OMIM: 608924) PREDICTED: forkhead bo ( 675) 750 111.4 7.4e-24 NP_612466 (OMIM: 608924) forkhead box protein P4 i ( 667) 748 111.1 8.9e-24 NP_001231737 (OMIM: 605515,613670) forkhead box pr ( 676) 544 84.1 1.2e-15 XP_016861656 (OMIM: 605515,613670) PREDICTED: fork ( 677) 544 84.1 1.2e-15 XP_005264793 (OMIM: 605515,613670) PREDICTED: fork ( 678) 544 84.1 1.2e-15 XP_005264799 (OMIM: 605515,613670) PREDICTED: fork ( 576) 535 82.9 2.4e-15 NP_001231742 (OMIM: 605515,613670) forkhead box pr ( 577) 535 82.9 2.4e-15 XP_011531890 (OMIM: 605515,613670) PREDICTED: fork ( 577) 535 82.9 2.4e-15 NP_001231741 (OMIM: 605515,613670) forkhead box pr ( 601) 535 82.9 2.4e-15 XP_005264794 (OMIM: 605515,613670) PREDICTED: fork ( 676) 535 83.0 2.6e-15 XP_006713165 (OMIM: 605515,613670) PREDICTED: fork ( 677) 535 83.0 2.6e-15 NP_001231743 (OMIM: 605515,613670) forkhead box pr ( 677) 535 83.0 2.6e-15 XP_011531886 (OMIM: 605515,613670) PREDICTED: fork ( 677) 535 83.0 2.6e-15 XP_011531887 (OMIM: 605515,613670) PREDICTED: fork ( 677) 535 83.0 2.6e-15 NP_001231745 (OMIM: 605515,613670) forkhead box pr ( 677) 535 83.0 2.6e-15 XP_006713166 (OMIM: 605515,613670) PREDICTED: fork ( 677) 535 83.0 2.6e-15 XP_016861655 (OMIM: 605515,613670) PREDICTED: fork ( 677) 535 83.0 2.6e-15 XP_016861654 (OMIM: 605515,613670) PREDICTED: fork ( 677) 535 83.0 2.6e-15 NP_116071 (OMIM: 605515,613670) forkhead box prote ( 677) 535 83.0 2.6e-15 XP_006713167 (OMIM: 605515,613670) PREDICTED: fork ( 677) 535 83.0 2.6e-15 XP_005264792 (OMIM: 605515,613670) PREDICTED: fork ( 678) 535 83.0 2.6e-15 NP_001231744 (OMIM: 605515,613670) forkhead box pr ( 679) 535 83.0 2.7e-15 NP_001166237 (OMIM: 602081,605317) forkhead box pr ( 714) 514 80.2 1.9e-14 NP_055306 (OMIM: 602081,605317) forkhead box prote ( 715) 514 80.2 1.9e-14 NP_683698 (OMIM: 602081,605317) forkhead box prote ( 732) 514 80.2 1.9e-14 NP_683696 (OMIM: 602081,605317) forkhead box prote ( 740) 514 80.2 1.9e-14 XP_016868290 (OMIM: 602081,605317) PREDICTED: fork ( 740) 514 80.2 1.9e-14 XP_011512595 (OMIM: 608924) PREDICTED: forkhead bo ( 581) 500 78.3 5.8e-14 XP_016865723 (OMIM: 608924) PREDICTED: forkhead bo ( 649) 500 78.3 6.3e-14 XP_011512594 (OMIM: 608924) PREDICTED: forkhead bo ( 655) 500 78.3 6.4e-14 NP_001012427 (OMIM: 608924) forkhead box protein P ( 678) 500 78.3 6.5e-14 XP_006715054 (OMIM: 608924) PREDICTED: forkhead bo ( 679) 500 78.3 6.5e-14 NP_001012426 (OMIM: 608924) forkhead box protein P ( 680) 500 78.3 6.5e-14 XP_011512592 (OMIM: 608924) PREDICTED: forkhead bo ( 685) 500 78.3 6.6e-14 XP_011512591 (OMIM: 608924) PREDICTED: forkhead bo ( 687) 500 78.3 6.6e-14 XP_016865722 (OMIM: 608924) PREDICTED: forkhead bo ( 687) 500 78.3 6.6e-14 NP_001231739 (OMIM: 605515,613670) forkhead box pr ( 693) 476 75.2 6e-13 NP_683697 (OMIM: 602081,605317) forkhead box prote ( 432) 276 48.6 3.8e-05 NP_001166238 (OMIM: 602081,605317) forkhead box pr ( 457) 276 48.6 4e-05 NP_005188 (OMIM: 602628) forkhead box protein N3 i ( 468) 268 47.5 8.4e-05 NP_001078940 (OMIM: 602628) forkhead box protein N ( 490) 268 47.6 8.7e-05 NP_005241 (OMIM: 603252) forkhead box protein L1 [ ( 345) 265 47.0 8.8e-05 XP_016856182 (OMIM: 616035) PREDICTED: forkhead bo ( 573) 265 47.2 0.00013 >>NP_054728 (OMIM: 222100,300292,304790) forkhead box pr (431 aa) initn: 3004 init1: 3004 opt: 3004 Z-score: 2161.1 bits: 409.0 E(85289): 1.2e-113 Smith-Waterman score: 3004; 100.0% identity (100.0% similar) in 431 aa overlap (1-431:1-431) 10 20 30 40 50 60 pF1KB7 MPNPRPGKPSAPSLALGPSPGASPSWRAAPKASDLLGARGPGGTFQGRDLRGGAHASSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 MPNPRPGKPSAPSLALGPSPGASPSWRAAPKASDLLGARGPGGTFQGRDLRGGAHASSSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 LNPMPPSQLQLPTLPLVMVAPSGARLGPLPHLQALLQDRPHFMHQLSTVDAHARTPVLQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 LNPMPPSQLQLPTLPLVMVAPSGARLGPLPHLQALLQDRPHFMHQLSTVDAHARTPVLQV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 HPLESPAMISLTPPTTATGVFSLKARPGLPPGINVASLEWVSREPALLCTFPNPSAPRKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 HPLESPAMISLTPPTTATGVFSLKARPGLPPGINVASLEWVSREPALLCTFPNPSAPRKD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 STLSAVPQSSYPLLANGVCKWPGCEKVFEEPEDFLKHCQADHLLDEKGRAQCLLQREMVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 STLSAVPQSSYPLLANGVCKWPGCEKVFEEPEDFLKHCQADHLLDEKGRAQCLLQREMVQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 SLEQQLVLEKEKLSAMQAHLAGKMALTKASSVASSDKGSCCIVAAGSQGPVVPAWSGPRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 SLEQQLVLEKEKLSAMQAHLAGKMALTKASSVASSDKGSCCIVAAGSQGPVVPAWSGPRE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 APDSLFAVRRHLWGSHGNSTFPEFLHNMDYFKFHNMRPPFTYATLIRWAILEAPEKQRTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 APDSLFAVRRHLWGSHGNSTFPEFLHNMDYFKFHNMRPPFTYATLIRWAILEAPEKQRTL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 NEIYHWFTRMFAFFRNHPATWKNAIRHNLSLHKCFVRVESEKGAVWTVDELEFRKKRSQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_054 NEIYHWFTRMFAFFRNHPATWKNAIRHNLSLHKCFVRVESEKGAVWTVDELEFRKKRSQR 370 380 390 400 410 420 430 pF1KB7 PSRCSNPTPGP ::::::::::: NP_054 PSRCSNPTPGP 430 >>XP_016885054 (OMIM: 222100,300292,304790) PREDICTED: f (516 aa) initn: 2402 init1: 2365 opt: 2407 Z-score: 1733.8 bits: 330.2 E(85289): 7.7e-90 Smith-Waterman score: 2791; 94.7% identity (94.7% similar) in 431 aa overlap (1-431:109-516) 10 20 30 pF1KB7 MPNPRPGKPSAPSLALGPSPGASPSWRAAP :::::::::::::::::::::::::::::: XP_016 LFLIRDSFPQARLILFCQSTSPSLPLDKDPMPNPRPGKPSAPSLALGPSPGASPSWRAAP 80 90 100 110 120 130 40 50 60 70 80 90 pF1KB7 KASDLLGARGPGGTFQGRDLRGGAHASSSSLNPMPPSQLQLPTLPLVMVAPSGARLGPLP :::::::::::::::::::::::::::::::::::::::: XP_016 KASDLLGARGPGGTFQGRDLRGGAHASSSSLNPMPPSQLQ-------------------- 140 150 160 170 100 110 120 130 140 150 pF1KB7 HLQALLQDRPHFMHQLSTVDAHARTPVLQVHPLESPAMISLTPPTTATGVFSLKARPGLP ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ---ALLQDRPHFMHQLSTVDAHARTPVLQVHPLESPAMISLTPPTTATGVFSLKARPGLP 180 190 200 210 220 230 160 170 180 190 200 210 pF1KB7 PGINVASLEWVSREPALLCTFPNPSAPRKDSTLSAVPQSSYPLLANGVCKWPGCEKVFEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGINVASLEWVSREPALLCTFPNPSAPRKDSTLSAVPQSSYPLLANGVCKWPGCEKVFEE 240 250 260 270 280 290 220 230 240 250 260 270 pF1KB7 PEDFLKHCQADHLLDEKGRAQCLLQREMVQSLEQQLVLEKEKLSAMQAHLAGKMALTKAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PEDFLKHCQADHLLDEKGRAQCLLQREMVQSLEQQLVLEKEKLSAMQAHLAGKMALTKAS 300 310 320 330 340 350 280 290 300 310 320 330 pF1KB7 SVASSDKGSCCIVAAGSQGPVVPAWSGPREAPDSLFAVRRHLWGSHGNSTFPEFLHNMDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVASSDKGSCCIVAAGSQGPVVPAWSGPREAPDSLFAVRRHLWGSHGNSTFPEFLHNMDY 360 370 380 390 400 410 340 350 360 370 380 390 pF1KB7 FKFHNMRPPFTYATLIRWAILEAPEKQRTLNEIYHWFTRMFAFFRNHPATWKNAIRHNLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FKFHNMRPPFTYATLIRWAILEAPEKQRTLNEIYHWFTRMFAFFRNHPATWKNAIRHNLS 420 430 440 450 460 470 400 410 420 430 pF1KB7 LHKCFVRVESEKGAVWTVDELEFRKKRSQRPSRCSNPTPGP ::::::::::::::::::::::::::::::::::::::::: XP_016 LHKCFVRVESEKGAVWTVDELEFRKKRSQRPSRCSNPTPGP 480 490 500 510 >>NP_001107849 (OMIM: 222100,300292,304790) forkhead box (396 aa) initn: 2270 init1: 2270 opt: 2274 Z-score: 1640.4 bits: 312.5 E(85289): 1.2e-84 Smith-Waterman score: 2678; 91.9% identity (91.9% similar) in 431 aa overlap (1-431:1-396) 10 20 30 40 50 60 pF1KB7 MPNPRPGKPSAPSLALGPSPGASPSWRAAPKASDLLGARGPGGTFQGRDLRGGAHASSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPNPRPGKPSAPSLALGPSPGASPSWRAAPKASDLLGARGPGGTFQGRDLRGGAHASSSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 LNPMPPSQLQLPTLPLVMVAPSGARLGPLPHLQALLQDRPHFMHQLSTVDAHARTPVLQV ::::::::::: :::::::::::::: NP_001 LNPMPPSQLQL-----------------------------------STVDAHARTPVLQV 70 80 130 140 150 160 170 180 pF1KB7 HPLESPAMISLTPPTTATGVFSLKARPGLPPGINVASLEWVSREPALLCTFPNPSAPRKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HPLESPAMISLTPPTTATGVFSLKARPGLPPGINVASLEWVSREPALLCTFPNPSAPRKD 90 100 110 120 130 140 190 200 210 220 230 240 pF1KB7 STLSAVPQSSYPLLANGVCKWPGCEKVFEEPEDFLKHCQADHLLDEKGRAQCLLQREMVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STLSAVPQSSYPLLANGVCKWPGCEKVFEEPEDFLKHCQADHLLDEKGRAQCLLQREMVQ 150 160 170 180 190 200 250 260 270 280 290 300 pF1KB7 SLEQQLVLEKEKLSAMQAHLAGKMALTKASSVASSDKGSCCIVAAGSQGPVVPAWSGPRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLEQQLVLEKEKLSAMQAHLAGKMALTKASSVASSDKGSCCIVAAGSQGPVVPAWSGPRE 210 220 230 240 250 260 310 320 330 340 350 360 pF1KB7 APDSLFAVRRHLWGSHGNSTFPEFLHNMDYFKFHNMRPPFTYATLIRWAILEAPEKQRTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 APDSLFAVRRHLWGSHGNSTFPEFLHNMDYFKFHNMRPPFTYATLIRWAILEAPEKQRTL 270 280 290 300 310 320 370 380 390 400 410 420 pF1KB7 NEIYHWFTRMFAFFRNHPATWKNAIRHNLSLHKCFVRVESEKGAVWTVDELEFRKKRSQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NEIYHWFTRMFAFFRNHPATWKNAIRHNLSLHKCFVRVESEKGAVWTVDELEFRKKRSQR 330 340 350 360 370 380 430 pF1KB7 PSRCSNPTPGP ::::::::::: NP_001 PSRCSNPTPGP 390 >>XP_016885055 (OMIM: 222100,300292,304790) PREDICTED: f (504 aa) initn: 2307 init1: 2270 opt: 2274 Z-score: 1639.0 bits: 312.6 E(85289): 1.5e-84 Smith-Waterman score: 2678; 91.9% identity (91.9% similar) in 431 aa overlap (1-431:109-504) 10 20 30 pF1KB7 MPNPRPGKPSAPSLALGPSPGASPSWRAAP :::::::::::::::::::::::::::::: XP_016 LFLIRDSFPQARLILFCQSTSPSLPLDKDPMPNPRPGKPSAPSLALGPSPGASPSWRAAP 80 90 100 110 120 130 40 50 60 70 80 90 pF1KB7 KASDLLGARGPGGTFQGRDLRGGAHASSSSLNPMPPSQLQLPTLPLVMVAPSGARLGPLP ::::::::::::::::::::::::::::::::::::::::: XP_016 KASDLLGARGPGGTFQGRDLRGGAHASSSSLNPMPPSQLQL------------------- 140 150 160 170 100 110 120 130 140 150 pF1KB7 HLQALLQDRPHFMHQLSTVDAHARTPVLQVHPLESPAMISLTPPTTATGVFSLKARPGLP :::::::::::::::::::::::::::::::::::::::::::: XP_016 ----------------STVDAHARTPVLQVHPLESPAMISLTPPTTATGVFSLKARPGLP 180 190 200 210 220 160 170 180 190 200 210 pF1KB7 PGINVASLEWVSREPALLCTFPNPSAPRKDSTLSAVPQSSYPLLANGVCKWPGCEKVFEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGINVASLEWVSREPALLCTFPNPSAPRKDSTLSAVPQSSYPLLANGVCKWPGCEKVFEE 230 240 250 260 270 280 220 230 240 250 260 270 pF1KB7 PEDFLKHCQADHLLDEKGRAQCLLQREMVQSLEQQLVLEKEKLSAMQAHLAGKMALTKAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PEDFLKHCQADHLLDEKGRAQCLLQREMVQSLEQQLVLEKEKLSAMQAHLAGKMALTKAS 290 300 310 320 330 340 280 290 300 310 320 330 pF1KB7 SVASSDKGSCCIVAAGSQGPVVPAWSGPREAPDSLFAVRRHLWGSHGNSTFPEFLHNMDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVASSDKGSCCIVAAGSQGPVVPAWSGPREAPDSLFAVRRHLWGSHGNSTFPEFLHNMDY 350 360 370 380 390 400 340 350 360 370 380 390 pF1KB7 FKFHNMRPPFTYATLIRWAILEAPEKQRTLNEIYHWFTRMFAFFRNHPATWKNAIRHNLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FKFHNMRPPFTYATLIRWAILEAPEKQRTLNEIYHWFTRMFAFFRNHPATWKNAIRHNLS 410 420 430 440 450 460 400 410 420 430 pF1KB7 LHKCFVRVESEKGAVWTVDELEFRKKRSQRPSRCSNPTPGP ::::::::::::::::::::::::::::::::::::::::: XP_016 LHKCFVRVESEKGAVWTVDELEFRKKRSQRPSRCSNPTPGP 470 480 490 500 >>XP_016885056 (OMIM: 222100,300292,304790) PREDICTED: f (473 aa) initn: 1963 init1: 1926 opt: 1932 Z-score: 1395.2 bits: 267.4 E(85289): 5.6e-71 Smith-Waterman score: 2345; 79.5% identity (79.5% similar) in 463 aa overlap (1-403:18-445) 10 20 30 40 pF1KB7 MPNPRPGKPSAPSLALGPSPGASPSWRAAPKASDLLGARGPGG ::::::::::::::::::::::::::::::::::::::::::: XP_016 MYPATVIPASLPLDKDPMPNPRPGKPSAPSLALGPSPGASPSWRAAPKASDLLGARGPGG 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB7 TFQGRDLRGGAHASSSSLNPMPPSQLQLPTLPLVMVAPSGARLGPLPHLQALLQDRPHFM :::::::::::::::::::::::::::: XP_016 TFQGRDLRGGAHASSSSLNPMPPSQLQL-------------------------------- 70 80 110 120 130 140 150 160 pF1KB7 HQLSTVDAHARTPVLQVHPLESPAMISLTPPTTATGVFSLKARPGLPPGINVASLEWVSR ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ---STVDAHARTPVLQVHPLESPAMISLTPPTTATGVFSLKARPGLPPGINVASLEWVSR 90 100 110 120 130 140 170 180 190 200 210 220 pF1KB7 EPALLCTFPNPSAPRKDSTLSAVPQSSYPLLANGVCKWPGCEKVFEEPEDFLKHCQADHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EPALLCTFPNPSAPRKDSTLSAVPQSSYPLLANGVCKWPGCEKVFEEPEDFLKHCQADHL 150 160 170 180 190 200 230 240 250 260 270 280 pF1KB7 LDEKGRAQCLLQREMVQSLEQQLVLEKEKLSAMQAHLAGKMALTKASSVASSDKGSCCIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LDEKGRAQCLLQREMVQSLEQQLVLEKEKLSAMQAHLAGKMALTKASSVASSDKGSCCIV 210 220 230 240 250 260 290 300 310 320 330 340 pF1KB7 AAGSQGPVVPAWSGPREAPDSLFAVRRHLWGSHGNSTFPEFLHNMDYFKFHNMRPPFTYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AAGSQGPVVPAWSGPREAPDSLFAVRRHLWGSHGNSTFPEFLHNMDYFKFHNMRPPFTYA 270 280 290 300 310 320 350 360 370 380 pF1KB7 TLIRWAILEAPEKQRTLNEIYHWFTRMFAFFRNHPATWK--------------------- ::::::::::::::::::::::::::::::::::::::: XP_016 TLIRWAILEAPEKQRTLNEIYHWFTRMFAFFRNHPATWKVSSSEVAVTGMASSAIAAQSG 330 340 350 360 370 380 390 400 pF1KB7 ---------------------------------------NAIRHNLSLHKCFVRVESEKG ::::::::::::::::::::: XP_016 QAWVWAHRHIGEERDVGCWWWLLASEVDAHLLPVPGLPQNAIRHNLSLHKCFVRVESEKG 390 400 410 420 430 440 410 420 430 pF1KB7 AVWTVDELEFRKKRSQRPSRCSNPTPGP XP_016 AVWTVDELEFRKKRSQRPSRCSNPTPGP 450 460 470 >>XP_011542218 (OMIM: 222100,300292,304790) PREDICTED: f (564 aa) initn: 1963 init1: 1926 opt: 1932 Z-score: 1394.2 bits: 267.4 E(85289): 6.4e-71 Smith-Waterman score: 2345; 79.5% identity (79.5% similar) in 463 aa overlap (1-403:109-536) 10 20 30 pF1KB7 MPNPRPGKPSAPSLALGPSPGASPSWRAAP :::::::::::::::::::::::::::::: XP_011 LFLIRDSFPQARLILFCQSTSPSLPLDKDPMPNPRPGKPSAPSLALGPSPGASPSWRAAP 80 90 100 110 120 130 40 50 60 70 80 90 pF1KB7 KASDLLGARGPGGTFQGRDLRGGAHASSSSLNPMPPSQLQLPTLPLVMVAPSGARLGPLP ::::::::::::::::::::::::::::::::::::::::: XP_011 KASDLLGARGPGGTFQGRDLRGGAHASSSSLNPMPPSQLQL------------------- 140 150 160 170 100 110 120 130 140 150 pF1KB7 HLQALLQDRPHFMHQLSTVDAHARTPVLQVHPLESPAMISLTPPTTATGVFSLKARPGLP :::::::::::::::::::::::::::::::::::::::::::: XP_011 ----------------STVDAHARTPVLQVHPLESPAMISLTPPTTATGVFSLKARPGLP 180 190 200 210 220 160 170 180 190 200 210 pF1KB7 PGINVASLEWVSREPALLCTFPNPSAPRKDSTLSAVPQSSYPLLANGVCKWPGCEKVFEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGINVASLEWVSREPALLCTFPNPSAPRKDSTLSAVPQSSYPLLANGVCKWPGCEKVFEE 230 240 250 260 270 280 220 230 240 250 260 270 pF1KB7 PEDFLKHCQADHLLDEKGRAQCLLQREMVQSLEQQLVLEKEKLSAMQAHLAGKMALTKAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PEDFLKHCQADHLLDEKGRAQCLLQREMVQSLEQQLVLEKEKLSAMQAHLAGKMALTKAS 290 300 310 320 330 340 280 290 300 310 320 330 pF1KB7 SVASSDKGSCCIVAAGSQGPVVPAWSGPREAPDSLFAVRRHLWGSHGNSTFPEFLHNMDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVASSDKGSCCIVAAGSQGPVVPAWSGPREAPDSLFAVRRHLWGSHGNSTFPEFLHNMDY 350 360 370 380 390 400 340 350 360 370 380 pF1KB7 FKFHNMRPPFTYATLIRWAILEAPEKQRTLNEIYHWFTRMFAFFRNHPATWK-------- :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FKFHNMRPPFTYATLIRWAILEAPEKQRTLNEIYHWFTRMFAFFRNHPATWKVSSSEVAV 410 420 430 440 450 460 390 pF1KB7 ----------------------------------------------------NAIRHNLS :::::::: XP_011 TGMASSAIAAQSGQAWVWAHRHIGEERDVGCWWWLLASEVDAHLLPVPGLPQNAIRHNLS 470 480 490 500 510 520 400 410 420 430 pF1KB7 LHKCFVRVESEKGAVWTVDELEFRKKRSQRPSRCSNPTPGP ::::::::::::: XP_011 LHKCFVRVESEKGAVWTVDELEFRKKRSQRPSRCSNPTPGP 530 540 550 560 >>XP_006724596 (OMIM: 222100,300292,304790) PREDICTED: f (454 aa) initn: 1758 init1: 1758 opt: 1783 Z-score: 1289.1 bits: 247.7 E(85289): 4.6e-65 Smith-Waterman score: 2948; 94.9% identity (94.9% similar) in 454 aa overlap (1-431:1-454) 10 20 30 40 50 60 pF1KB7 MPNPRPGKPSAPSLALGPSPGASPSWRAAPKASDLLGARGPGGTFQGRDLRGGAHASSSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MPNPRPGKPSAPSLALGPSPGASPSWRAAPKASDLLGARGPGGTFQGRDLRGGAHASSSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 LNPMPPSQLQLPTLPLVMVAPSGARLGPLPHLQALLQDRPHFMHQLSTVDAHARTPVLQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LNPMPPSQLQLPTLPLVMVAPSGARLGPLPHLQALLQDRPHFMHQLSTVDAHARTPVLQV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 HPLESPAMISLTPPTTATGVFSLKARPGLPPGINVASLEWVSREPALLCTFPNPSAPRKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HPLESPAMISLTPPTTATGVFSLKARPGLPPGINVASLEWVSREPALLCTFPNPSAPRKD 130 140 150 160 170 180 190 200 210 pF1KB7 -----------------------STLSAVPQSSYPLLANGVCKWPGCEKVFEEPEDFLKH ::::::::::::::::::::::::::::::::::::: XP_006 RSVDRAGKDPRPPIPSPDTLCPPSTLSAVPQSSYPLLANGVCKWPGCEKVFEEPEDFLKH 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB7 CQADHLLDEKGRAQCLLQREMVQSLEQQLVLEKEKLSAMQAHLAGKMALTKASSVASSDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 CQADHLLDEKGRAQCLLQREMVQSLEQQLVLEKEKLSAMQAHLAGKMALTKASSVASSDK 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB7 GSCCIVAAGSQGPVVPAWSGPREAPDSLFAVRRHLWGSHGNSTFPEFLHNMDYFKFHNMR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GSCCIVAAGSQGPVVPAWSGPREAPDSLFAVRRHLWGSHGNSTFPEFLHNMDYFKFHNMR 310 320 330 340 350 360 340 350 360 370 380 390 pF1KB7 PPFTYATLIRWAILEAPEKQRTLNEIYHWFTRMFAFFRNHPATWKNAIRHNLSLHKCFVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PPFTYATLIRWAILEAPEKQRTLNEIYHWFTRMFAFFRNHPATWKNAIRHNLSLHKCFVR 370 380 390 400 410 420 400 410 420 430 pF1KB7 VESEKGAVWTVDELEFRKKRSQRPSRCSNPTPGP :::::::::::::::::::::::::::::::::: XP_006 VESEKGAVWTVDELEFRKKRSQRPSRCSNPTPGP 430 440 450 >>XP_011512593 (OMIM: 608924) PREDICTED: forkhead box pr (675 aa) initn: 768 init1: 478 opt: 750 Z-score: 549.3 bits: 111.4 E(85289): 7.4e-24 Smith-Waterman score: 750; 39.7% identity (63.5% similar) in 378 aa overlap (69-428:195-551) 40 50 60 70 80 90 pF1KB7 RGPGGTFQGRDLRGGAHASSSSLNPMPPSQLQLPTLPLVMVAPSGARLGPLPHLQALLQD :.: :: . :. : ::: :.: : XP_011 KPQPKEALGNKQLAFQQQLLQMQQLQQQHLLNLQRQGLVSLQPNQAS-GPL---QTLPQA 170 180 190 200 210 220 100 110 120 130 140 pF1KB7 RPHFMHQLSTVDAHARTPVLQVHPLES----PAMIS-----LTPPTTATGVFSLKARPGL : .: . : : . :. :. :: : : ::. . :. : : . XP_011 SP-----VSPTAAVCPTDLPQLWKGEGAPGQPAEDSVKQEGLDLTGTAATATSFAAPPKV 230 240 250 260 270 150 160 170 180 190 200 pF1KB7 PPGINVASLEWVSREPALLCTFPNPSAPRKDSTLSAVPQSSYPLLANGVCKWPGCEKVFE : .. .: . .:..: . :.::. .:.:: ..: ::::::: . : XP_011 SPPLSHHTLP--NGQPTVLTS-------RRDSSSHEETPGSHPLYGHGECKWPGCETLCE 280 290 300 310 320 210 220 230 240 250 260 pF1KB7 EPEDFLKHCQADHLLDEKGRAQCLLQREMVQSLEQQLVLEKEKLSAMQAHLAGKMA---- . .:.:: ...: ::... ::: .: ..::.:: ::. :.:.:.::.::: . . XP_011 DLGQFIKHLNTEHALDDRSTAQCRVQMQVVQQLEIQLAKESERLQAMMAHLHMRPSEPKP 330 340 350 360 370 380 270 280 290 300 310 320 pF1KB7 LTKASSVASSDKGSCCIV--AAGSQGPVVPAWSGPREAPDSLFA---VRRHLWGSHGNST ... .:...:. .: ... .::.: : . :: . .::. . . XP_011 FSQPVTVSAADSFPDGLVHPPTSAAAPVTPL-RPPGLGSASLHGGGPARRRSSDKFCSPI 390 400 410 420 430 440 330 340 350 360 370 380 pF1KB7 FPEFLHNMDYFKFHNMRPPFTYATLIRWAILEAPEKQRTLNEIYHWFTRMFAFFRNHPAT :. .: ...: ..:::::::.::: ::::.:..: ::::::.:::::::.:: . :: XP_011 SSELAQNHEFYKNADVRPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTAT 450 460 470 480 490 500 390 400 410 420 430 pF1KB7 WKNAIRHNLSLHKCFVRVESEKGAVWTVDELEFRKKRSQRPSRCSNPTPGP ::::.::::::::::::::. ::::::::: :..:.: :. ..:: XP_011 WKNAVRHNLSLHKCFVRVENVKGAVWTVDEREYQKRRP--PKMTGSPTLVKNMISGLSYG 510 520 530 540 550 560 XP_011 ALNASYQAALAESSFPLLNSPGMLNPGSASSLLPLSHDDVGAPVEPLPSNGSSSPPRLSP 570 580 590 600 610 620 >>NP_612466 (OMIM: 608924) forkhead box protein P4 isofo (667 aa) initn: 768 init1: 478 opt: 748 Z-score: 547.9 bits: 111.1 E(85289): 8.9e-24 Smith-Waterman score: 756; 39.9% identity (65.2% similar) in 371 aa overlap (69-428:195-543) 40 50 60 70 80 90 pF1KB7 RGPGGTFQGRDLRGGAHASSSSLNPMPPSQLQLPTLPLVMVAPSGARLGPLPHL-QALLQ :.: :: . :. : ::: : ::. NP_612 KPQPKEALGNKQLAFQQQLLQMQQLQQQHLLNLQRQGLVSLQPNQAS-GPLQTLPQAVCP 170 180 190 200 210 220 100 110 120 130 140 150 pF1KB7 -DRPHFMHQLSTVDAHARTPVLQVHPLESPAMISLTPPTTATGVFSLKARPGLPPGINVA : :.. . .. :. : : :. ..:: ::. . :. : : . : .. NP_612 TDLPQLWKGEGAPGQPAEDSVKQ----EG---LDLTG--TAATATSFAAPPKVSPPLSHH 230 240 250 260 270 160 170 180 190 200 210 pF1KB7 SLEWVSREPALLCTFPNPSAPRKDSTLSAVPQSSYPLLANGVCKWPGCEKVFEEPEDFLK .: . .:..: . :.::. .:.:: ..: ::::::: . :. .:.: NP_612 TLP--NGQPTVLTS-------RRDSSSHEETPGSHPLYGHGECKWPGCETLCEDLGQFIK 280 290 300 310 320 220 230 240 250 260 270 pF1KB7 HCQADHLLDEKGRAQCLLQREMVQSLEQQLVLEKEKLSAMQAHLAGKMA----LTKASSV : ...: ::... ::: .: ..::.:: ::. :.:.:.::.::: . . ... .: NP_612 HLNTEHALDDRSTAQCRVQMQVVQQLEIQLAKESERLQAMMAHLHMRPSEPKPFSQPVTV 330 340 350 360 370 380 280 290 300 310 320 pF1KB7 ASSDKGSCCIV--AAGSQGPVVPAWSGPREAPDSLFA---VRRHLWGSHGNSTFPEFLHN ...:. .: ... .::.: : . :: . .::. . . :. .: NP_612 SAADSFPDGLVHPPTSAAAPVTPL-RPPGLGSASLHGGGPARRRSSDKFCSPISSELAQN 390 400 410 420 430 440 330 340 350 360 370 380 pF1KB7 MDYFKFHNMRPPFTYATLIRWAILEAPEKQRTLNEIYHWFTRMFAFFRNHPATWKNAIRH ...: ..:::::::.::: ::::.:..: ::::::.:::::::.:: . ::::::.:: NP_612 HEFYKNADVRPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWKNAVRH 450 460 470 480 490 500 390 400 410 420 430 pF1KB7 NLSLHKCFVRVESEKGAVWTVDELEFRKKRSQRPSRCSNPTPGP ::::::::::::. ::::::::: :..:.: :. ..:: NP_612 NLSLHKCFVRVENVKGAVWTVDEREYQKRRP--PKMTGSPTLVKNMISGLSYGALNASYQ 510 520 530 540 550 560 NP_612 AALAESSFPLLNSPGMLNPGSASSLLPLSHDDVGAPVEPLPSNGSSSPPRLSPPQYSHQV 570 580 590 600 610 620 >>NP_001231737 (OMIM: 605515,613670) forkhead box protei (676 aa) initn: 763 init1: 499 opt: 544 Z-score: 402.2 bits: 84.1 E(85289): 1.2e-15 Smith-Waterman score: 780; 39.4% identity (63.0% similar) in 373 aa overlap (89-428:185-553) 60 70 80 90 100 110 pF1KB7 SSLNPMPPSQLQLPTLPLVMVAPSGARLGPLPHLQALLQDRPHFMHQLSTVDAHARTPVL : ..: : :.. ... . . . :.: NP_001 QLQLLQQQHAGKQPKEQQQVATQQLAFQQQLLQMQQLQQQHLLSLQRQGLLTIQPGQPAL 160 170 180 190 200 210 120 130 140 150 160 170 pF1KB7 QVHPLESPAMISLTPPTTATGVFSLKARPGLPPGINVASLEWV-----SREPALLCTFPN ..:: . .:: : : .. : : .::. . : :. . : NP_001 PLQPL-AQGMIPTELQQLWKEVTSAHTAEETT-GNNHSSLDLTTTCVSSSAPSKTSLIMN 220 230 240 250 260 270 180 190 200 210 220 pF1KB7 PSA----------PRKDSTLSAVPQSSYPLLANGVCKWPGCEKVFEEPEDFLKHCQADHL : : :...: :.:: ..::::::::: : :. ..:::: ...: NP_001 PHASTNGQLSVHTPKRESLSHEEHPHSHPLYGHGVCKWPGCEAVCEDFQSFLKHLNSEHA 280 290 300 310 320 330 230 240 250 260 270 pF1KB7 LDEKGRAQCLLQREMVQSLEQQLVLEKEKLSAMQAHLAGKMALTKAS----SVASSDKGS ::... ::: .: ..::.:: ::. .::.:.::..:: : . ::. ...:: : NP_001 LDDRSTAQCRVQMQVVQQLELQLAKDKERLQAMMTHLHVKSTEPKAAPQPLNLVSSVTLS 340 350 360 370 380 390 280 290 300 310 320 pF1KB7 CCIVAAGSQG----------PVVPAWSGPR----EAPDSLFAVRRHLWGSHGNSTFPEFL :. :. :..:. .:: . .. .::. ... .. NP_001 KSASEASPQSLPHTPTTPTAPLTPVTQGPSVITTTSMHTVGPIRRRYSDKYNVPISSDIA 400 410 420 430 440 450 330 340 350 360 370 380 pF1KB7 HNMDYFKFHNMRPPFTYATLIRWAILEAPEKQRTLNEIYHWFTRMFAFFRNHPATWKNAI .:....: ..:::::::.::: ::::.:::: ::::::.:::::::.:: . ::::::. NP_001 QNQEFYKNAEVRPPFTYASLIRQAILESPEKQLTLNEIYNWFTRMFAYFRRNAATWKNAV 460 470 480 490 500 510 390 400 410 420 430 pF1KB7 RHNLSLHKCFVRVESEKGAVWTVDELEFRKKRSQRPSRCSNPTPGP ::::::::::::::. :::::::::.::.:.: :. : .::. NP_001 RHNLSLHKCFVRVENVKGAVWTVDEVEFQKRRPQKIS--GNPSLIKNMQSSHAYCTPLNA 520 530 540 550 560 570 NP_001 ALQASMAENSIPLYTTASMGNPTLGNLASAIREELNGAMEHTNSNESDSSPGRSPMQAVH 580 590 600 610 620 630 431 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 05:54:05 2016 done: Fri Nov 4 05:54:06 2016 Total Scan time: 11.000 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]