FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7204, 189 aa 1>>>pF1KB7204 189 - 189 aa - 189 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2636+/-0.000408; mu= 12.6960+/- 0.025 mean_var=58.2362+/-11.647, 0's: 0 Z-trim(110.9): 17 B-trim: 38 in 1/50 Lambda= 0.168065 statistics sampled from 19319 (19336) to 19319 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.608), E-opt: 0.2 (0.227), width: 16 Scan time: 5.580 The best scores are: opt bits E(85289) NP_002164 (OMIM: 147580) interferon alpha-16 precu ( 189) 1242 309.5 2.1e-84 NP_066546 (OMIM: 147564) interferon alpha-4 precur ( 189) 1106 276.5 1.8e-74 NP_067091 (OMIM: 147583) interferon alpha-17 precu ( 189) 1082 270.7 1e-72 NP_002162 (OMIM: 147577) interferon alpha-10 precu ( 189) 1081 270.4 1.2e-72 NP_066401 (OMIM: 147567) interferon alpha-7 precur ( 189) 1061 265.6 3.4e-71 NP_002166 (OMIM: 147584) interferon alpha-21 precu ( 189) 1053 263.6 1.3e-70 NP_002163 (OMIM: 147579) interferon alpha-14 precu ( 189) 1040 260.5 1.2e-69 NP_002160 (OMIM: 147565) interferon alpha-5 precur ( 189) 1039 260.3 1.4e-69 NP_000596 (OMIM: 147562) interferon alpha-2 precur ( 188) 991 248.6 4.4e-66 NP_066282 (OMIM: 147566) interferon alpha-6 precur ( 189) 975 244.7 6.5e-65 NP_002161 (OMIM: 147568) interferon alpha-8 precur ( 189) 973 244.3 9.1e-65 NP_008831 (OMIM: 147578) interferon alpha-1/13 pre ( 190) 944 237.2 1.2e-62 NP_076918 (OMIM: 147660) interferon alpha-1/13 pre ( 189) 939 236.0 2.7e-62 NP_002168 (OMIM: 147553) interferon omega-1 precur ( 195) 681 173.5 1.9e-43 NP_002167 (OMIM: 147640) interferon beta precursor ( 187) 347 92.5 4.4e-19 NP_795372 (OMIM: 615223) interferon epsilon precur ( 208) 340 90.8 1.6e-18 NP_064509 (OMIM: 615326) interferon kappa precurso ( 207) 158 46.7 3e-05 >>NP_002164 (OMIM: 147580) interferon alpha-16 precursor (189 aa) initn: 1242 init1: 1242 opt: 1242 Z-score: 1636.3 bits: 309.5 E(85289): 2.1e-84 Smith-Waterman score: 1242; 100.0% identity (100.0% similar) in 189 aa overlap (1-189:1-189) 10 20 30 40 50 60 pF1KB7 MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLAQMGRISHFSCLKDRYDFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLAQMGRISHFSCLKDRYDFG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 FPQEVFDGNQFQKAQAISAFHEMIQQTFNLFSTKDSSAAWDETLLDKFYIELFQQLNDLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 FPQEVFDGNQFQKAQAISAFHEMIQQTFNLFSTKDSSAAWDETLLDKFYIELFQQLNDLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 ACVTQEVGVEEIALMNEDSILAVRKYFQRITLYLMGKKYSPCAWEVVRAEIMRSFSFSTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ACVTQEVGVEEIALMNEDSILAVRKYFQRITLYLMGKKYSPCAWEVVRAEIMRSFSFSTN 130 140 150 160 170 180 pF1KB7 LQKGLRRKD ::::::::: NP_002 LQKGLRRKD >>NP_066546 (OMIM: 147564) interferon alpha-4 precursor (189 aa) initn: 1106 init1: 1106 opt: 1106 Z-score: 1458.1 bits: 276.5 E(85289): 1.8e-74 Smith-Waterman score: 1106; 88.9% identity (95.2% similar) in 189 aa overlap (1-189:1-189) 10 20 30 40 50 60 pF1KB7 MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLAQMGRISHFSCLKDRYDFG ::::::::::::::::::::::::::::::::::::::::::::::::::::::::.::: NP_066 MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLAQMGRISHFSCLKDRHDFG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 FPQEVFDGNQFQKAQAISAFHEMIQQTFNLFSTKDSSAAWDETLLDKFYIELFQQLNDLE ::.: :::.:::::::::..:::::::::::::.::::::...::.:: ::.::::::: NP_066 FPEEEFDGHQFQKAQAISVLHEMIQQTFNLFSTEDSSAAWEQSLLEKFSTELYQQLNDLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 ACVTQEVGVEEIALMNEDSILAVRKYFQRITLYLMGKKYSPCAWEVVRAEIMRSFSFSTN ::: ::::::: ::::::::::::::::::::: ::::::::::::::::::.::::: NP_066 ACVIQEVGVEETPLMNEDSILAVRKYFQRITLYLTEKKYSPCAWEVVRAEIMRSLSFSTN 130 140 150 160 170 180 pF1KB7 LQKGLRRKD ::: ::::: NP_066 LQKRLRRKD >>NP_067091 (OMIM: 147583) interferon alpha-17 precursor (189 aa) initn: 1082 init1: 1082 opt: 1082 Z-score: 1426.6 bits: 270.7 E(85289): 1e-72 Smith-Waterman score: 1082; 87.3% identity (94.7% similar) in 189 aa overlap (1-189:1-189) 10 20 30 40 50 60 pF1KB7 MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLAQMGRISHFSCLKDRYDFG :::::::::::::::::::::::::::::::::::::::::::::::: :::::::.::: NP_067 MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLAQMGRISPFSCLKDRHDFG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 FPQEVFDGNQFQKAQAISAFHEMIQQTFNLFSTKDSSAAWDETLLDKFYIELFQQLNDLE .::: ::::::::.::::..:::::::::::::.::::::...::.:: ::.::::.:: NP_067 LPQEEFDGNQFQKTQAISVLHEMIQQTFNLFSTEDSSAAWEQSLLEKFSTELYQQLNNLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 ACVTQEVGVEEIALMNEDSILAVRKYFQRITLYLMGKKYSPCAWEVVRAEIMRSFSFSTN ::: ::::.:: ::::::::::::::::::::: ::::::::::::::::::.::::: NP_067 ACVIQEVGMEETPLMNEDSILAVRKYFQRITLYLTEKKYSPCAWEVVRAEIMRSLSFSTN 130 140 150 160 170 180 pF1KB7 LQKGLRRKD ::: ::::: NP_067 LQKILRRKD >>NP_002162 (OMIM: 147577) interferon alpha-10 precursor (189 aa) initn: 1081 init1: 1081 opt: 1081 Z-score: 1425.3 bits: 270.4 E(85289): 1.2e-72 Smith-Waterman score: 1081; 87.3% identity (94.7% similar) in 189 aa overlap (1-189:1-189) 10 20 30 40 50 60 pF1KB7 MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLAQMGRISHFSCLKDRYDFG :::::::::::::::::::::::::::::::::::::::::.:::::: :::::::.:: NP_002 MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLGQMGRISPFSCLKDRHDFR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 FPQEVFDGNQFQKAQAISAFHEMIQQTFNLFSTKDSSAAWDETLLDKFYIELFQQLNDLE .::: :::::::::::::..:::::::::::::.::::::...::.:: ::.::::::: NP_002 IPQEEFDGNQFQKAQAISVLHEMIQQTFNLFSTEDSSAAWEQSLLEKFSTELYQQLNDLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 ACVTQEVGVEEIALMNEDSILAVRKYFQRITLYLMGKKYSPCAWEVVRAEIMRSFSFSTN ::: ::::::: :::::::::::::::::::::. .:::::::::::::::::.::::: NP_002 ACVIQEVGVEETPLMNEDSILAVRKYFQRITLYLIERKYSPCAWEVVRAEIMRSLSFSTN 130 140 150 160 170 180 pF1KB7 LQKGLRRKD ::: ::::: NP_002 LQKRLRRKD >>NP_066401 (OMIM: 147567) interferon alpha-7 precursor (189 aa) initn: 1061 init1: 1061 opt: 1061 Z-score: 1399.1 bits: 265.6 E(85289): 3.4e-71 Smith-Waterman score: 1061; 85.7% identity (93.7% similar) in 189 aa overlap (1-189:1-189) 10 20 30 40 50 60 pF1KB7 MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLAQMGRISHFSCLKDRYDFG :: ::::::.:::::::::::::::::::::: ::::::::::::::: :::::::..: NP_066 MARSFSLLMVVLVLSYKSICSLGCDLPQTHSLRNRRALILLAQMGRISPFSCLKDRHEFR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 FPQEVFDGNQFQKAQAISAFHEMIQQTFNLFSTKDSSAAWDETLLDKFYIELFQQLNDLE ::.: :::.::::.::::..:::::::::::::.::::::...::.:: ::.::::::: NP_066 FPEEEFDGHQFQKTQAISVLHEMIQQTFNLFSTEDSSAAWEQSLLEKFSTELYQQLNDLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 ACVTQEVGVEEIALMNEDSILAVRKYFQRITLYLMGKKYSPCAWEVVRAEIMRSFSFSTN ::: ::::::: ::::: :::::::::::::::: :::::::::::::::::::::::: NP_066 ACVIQEVGVEETPLMNEDFILAVRKYFQRITLYLMEKKYSPCAWEVVRAEIMRSFSFSTN 130 140 150 160 170 180 pF1KB7 LQKGLRRKD :.::::::: NP_066 LKKGLRRKD >>NP_002166 (OMIM: 147584) interferon alpha-21 precursor (189 aa) initn: 1074 init1: 1053 opt: 1053 Z-score: 1388.6 bits: 263.6 E(85289): 1.3e-70 Smith-Waterman score: 1053; 85.7% identity (92.6% similar) in 189 aa overlap (1-189:1-189) 10 20 30 40 50 60 pF1KB7 MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLAQMGRISHFSCLKDRYDFG :::::::::::::::::::::::::::::::::::::::::::::::: :::::::.::: NP_002 MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLAQMGRISPFSCLKDRHDFG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 FPQEVFDGNQFQKAQAISAFHEMIQQTFNLFSTKDSSAAWDETLLDKFYIELFQQLNDLE :::: :::::::::::::..::::::::::::::::::.:...::.:: :: ::::::: NP_002 FPQEEFDGNQFQKAQAISVLHEMIQQTFNLFSTKDSSATWEQSLLEKFSTELNQQLNDLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 ACVTQEVGVEEIALMNEDSILAVRKYFQRITLYLMGKKYSPCAWEVVRAEIMRSFSFSTN ::: ::::::: ::: ::::::.:::::::::: ::::::::::::::::::::.: NP_002 ACVIQEVGVEETPLMNVDSILAVKKYFQRITLYLTEKKYSPCAWEVVRAEIMRSFSLSKI 130 140 150 160 170 180 pF1KB7 LQKGLRRKD .:. ::::. NP_002 FQERLRRKE >>NP_002163 (OMIM: 147579) interferon alpha-14 precursor (189 aa) initn: 1040 init1: 1040 opt: 1040 Z-score: 1371.6 bits: 260.5 E(85289): 1.2e-69 Smith-Waterman score: 1040; 83.6% identity (93.1% similar) in 189 aa overlap (1-189:1-189) 10 20 30 40 50 60 pF1KB7 MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLAQMGRISHFSCLKDRYDFG ::: :.:.::..::: :: :::::.: :::::.:::.:.:.::: ::: :::::::.:: NP_002 MALPFALMMALVVLSCKSSCSLGCNLSQTHSLNNRRTLMLMAQMRRISPFSCLKDRHDFE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 FPQEVFDGNQFQKAQAISAFHEMIQQTFNLFSTKDSSAAWDETLLDKFYIELFQQLNDLE :::: :::::::::::::..:::.::::::::::.::::::::::.:::::::::.:::: NP_002 FPQEEFDGNQFQKAQAISVLHEMMQQTFNLFSTKNSSAAWDETLLEKFYIELFQQMNDLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 ACVTQEVGVEEIALMNEDSILAVRKYFQRITLYLMGKKYSPCAWEVVRAEIMRSFSFSTN ::: ::::::: ::::::::::.::::::::::: ::::::::::::::::::.::::: NP_002 ACVIQEVGVEETPLMNEDSILAVKKYFQRITLYLMEKKYSPCAWEVVRAEIMRSLSFSTN 130 140 150 160 170 180 pF1KB7 LQKGLRRKD ::: ::::: NP_002 LQKRLRRKD >>NP_002160 (OMIM: 147565) interferon alpha-5 precursor (189 aa) initn: 1039 init1: 1039 opt: 1039 Z-score: 1370.3 bits: 260.3 E(85289): 1.4e-69 Smith-Waterman score: 1039; 82.5% identity (93.1% similar) in 189 aa overlap (1-189:1-189) 10 20 30 40 50 60 pF1KB7 MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLAQMGRISHFSCLKDRYDFG ::: : ::::..::. ::::::::::::::::.:::.:...::::::: :::::::.::: NP_002 MALPFVLLMALVVLNCKSICSLGCDLPQTHSLSNRRTLMIMAQMGRISPFSCLKDRHDFG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 FPQEVFDGNQFQKAQAISAFHEMIQQTFNLFSTKDSSAAWDETLLDKFYIELFQQLNDLE :::: :::::::::::::..::::::::::::::::::.:::::::::: ::.::::::: NP_002 FPQEEFDGNQFQKAQAISVLHEMIQQTFNLFSTKDSSATWDETLLDKFYTELYQQLNDLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 ACVTQEVGVEEIALMNEDSILAVRKYFQRITLYLMGKKYSPCAWEVVRAEIMRSFSFSTN ::. ::::::. ::: ::::.:::::::::::: ::::::::::::::::::::.:.: NP_002 ACMMQEVGVEDTPLMNVDSILTVRKYFQRITLYLTEKKYSPCAWEVVRAEIMRSFSLSAN 130 140 150 160 170 180 pF1KB7 LQKGLRRKD ::. ::::. NP_002 LQERLRRKE >>NP_000596 (OMIM: 147562) interferon alpha-2 precursor (188 aa) initn: 989 init1: 654 opt: 991 Z-score: 1307.4 bits: 248.6 E(85289): 4.4e-66 Smith-Waterman score: 991; 81.0% identity (91.0% similar) in 189 aa overlap (1-189:1-188) 10 20 30 40 50 60 pF1KB7 MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLAQMGRISHFSCLKDRYDFG :::.:.::.:.:::: :: ::.:::::::::::.::.:.::::: ::: :::::::.::: NP_000 MALTFALLVALLVLSCKSSCSVGCDLPQTHSLGSRRTLMLLAQMRRISLFSCLKDRHDFG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 FPQEVFDGNQFQKAQAISAFHEMIQQTFNLFSTKDSSAAWDETLLDKFYIELFQQLNDLE :::: : :::::::..: ..:::::: :::::::::::::::::::::: ::.::::::: NP_000 FPQEEF-GNQFQKAETIPVLHEMIQQIFNLFSTKDSSAAWDETLLDKFYTELYQQLNDLE 70 80 90 100 110 130 140 150 160 170 180 pF1KB7 ACVTQEVGVEEIALMNEDSILAVRKYFQRITLYLMGKKYSPCAWEVVRAEIMRSFSFSTN ::: : ::: : ::.:::::::::::::::::: ::::::::::::::::::::.::: NP_000 ACVIQGVGVTETPLMKEDSILAVRKYFQRITLYLKEKKYSPCAWEVVRAEIMRSFSLSTN 120 130 140 150 160 170 pF1KB7 LQKGLRRKD ::..:: :. NP_000 LQESLRSKE 180 >>NP_066282 (OMIM: 147566) interferon alpha-6 precursor (189 aa) initn: 975 init1: 975 opt: 975 Z-score: 1286.4 bits: 244.7 E(85289): 6.5e-65 Smith-Waterman score: 975; 79.9% identity (88.9% similar) in 189 aa overlap (1-189:1-189) 10 20 30 40 50 60 pF1KB7 MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLAQMGRISHFSCLKDRYDFG ::: :.::::..::: :: ::: ::::::::::.::...::::: ::: :::::::.:: NP_066 MALPFALLMALVVLSCKSSCSLDCDLPQTHSLGHRRTMMLLAQMRRISLFSCLKDRHDFR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 FPQEVFDGNQFQKAQAISAFHEMIQQTFNLFSTKDSSAAWDETLLDKFYIELFQQLNDLE :::: :::::::::.:::..::.::::::::::::::.:::: ::::.: ::.::::::: NP_066 FPQEEFDGNQFQKAEAISVLHEVIQQTFNLFSTKDSSVAWDERLLDKLYTELYQQLNDLE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 ACVTQEVGVEEIALMNEDSILAVRKYFQRITLYLMGKKYSPCAWEVVRAEIMRSFSFSTN ::: ::: : ::::::::::::::::::::: :::::::::::::::::::: : : NP_066 ACVMQEVWVGGTPLMNEDSILAVRKYFQRITLYLTEKKYSPCAWEVVRAEIMRSFSSSRN 130 140 150 160 170 180 pF1KB7 LQKGLRRKD ::. ::::. NP_066 LQERLRRKE 189 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 05:56:37 2016 done: Fri Nov 4 05:56:37 2016 Total Scan time: 5.580 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]