FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7215, 111 aa 1>>>pF1KB7215 111 - 111 aa - 111 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9202+/-0.000254; mu= 12.8157+/- 0.016 mean_var=68.0620+/-13.114, 0's: 0 Z-trim(122.1): 30 B-trim: 0 in 0/53 Lambda= 0.155461 statistics sampled from 39690 (39724) to 39690 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.83), E-opt: 0.2 (0.466), width: 16 Scan time: 4.920 The best scores are: opt bits E(85289) NP_543145 (OMIM: 609872) WAP four-disulfide core d ( 111) 804 187.8 3.1e-48 NP_003055 (OMIM: 107285) antileukoproteinase precu ( 132) 207 53.9 7.2e-08 XP_011526903 (OMIM: 605161) PREDICTED: WAP four-di ( 123) 187 49.4 1.5e-06 XP_011526904 (OMIM: 605161) PREDICTED: WAP four-di ( 123) 187 49.4 1.5e-06 NP_663627 (OMIM: 605161) WAP four-disulfide core d ( 123) 187 49.4 1.5e-06 NP_002629 (OMIM: 182257) elafin preproprotein [Hom ( 117) 166 44.7 3.9e-05 NP_001289790 (OMIM: 609031) eppin isoform 2 precur ( 127) 149 40.9 0.00058 NP_065131 (OMIM: 609031) eppin isoform 1 precursor ( 133) 149 40.9 0.0006 >>NP_543145 (OMIM: 609872) WAP four-disulfide core domai (111 aa) initn: 804 init1: 804 opt: 804 Z-score: 986.9 bits: 187.8 E(85289): 3.1e-48 Smith-Waterman score: 804; 100.0% identity (100.0% similar) in 111 aa overlap (1-111:1-111) 10 20 30 40 50 60 pF1KB7 MGSSSFLVLMVSLVLVTLVAVEGVKEGIEKAGVCPADNVRCFKSDPPQCHTDQDCLGERK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_543 MGSSSFLVLMVSLVLVTLVAVEGVKEGIEKAGVCPADNVRCFKSDPPQCHTDQDCLGERK 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 CCYLHCGFKCVIPVKELEEGGNKDEDVSRPYPEPGWEAKCPGSSSTRCPQK ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_543 CCYLHCGFKCVIPVKELEEGGNKDEDVSRPYPEPGWEAKCPGSSSTRCPQK 70 80 90 100 110 >>NP_003055 (OMIM: 107285) antileukoproteinase precursor (132 aa) initn: 178 init1: 163 opt: 207 Z-score: 262.2 bits: 53.9 E(85289): 7.2e-08 Smith-Waterman score: 207; 41.6% identity (72.7% similar) in 77 aa overlap (1-74:1-76) 10 20 30 40 50 pF1KB7 MGSSSFLVLMVSLVLVTLV--AVEGVKEGIEKAGVCPAD-NVRCFKSDPPQCHTDQDCLG : ::... ..: :.: ::. :::: ... :::::: ...:.. :.:..: .: : NP_003 MKSSGLFPFLVLLALGTLAPWAVEGSGKSF-KAGVCPPKKSAQCLRYKKPECQSDWQCPG 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 ERKCCYLHCGFKCVIPVKELEEGGNKDEDVSRPYPEPGWEAKCPGSSSTRCPQK ...:: ::.::. :: NP_003 KKRCCPDTCGIKCLDPVDTPNPTRRKPGKCPVTYGQCLMLNPPNFCEMDGQCKRDLKCCM 60 70 80 90 100 110 >-- initn: 124 init1: 80 opt: 150 Z-score: 193.1 bits: 41.2 E(85289): 0.00051 Smith-Waterman score: 150; 42.6% identity (63.8% similar) in 47 aa overlap (30-75:85-131) 10 20 30 40 50 pF1KB7 MGSSSFLVLMVSLVLVTLVAVEGVKEGIEKAGVCPADNVRCFKSDPPQ-CHTDQDCLGE : : ::. .:. .::. :. : .: . NP_003 WQCPGKKRCCPDTCGIKCLDPVDTPNPTRRKPGKCPVTYGQCLMLNPPNFCEMDGQCKRD 60 70 80 90 100 110 60 70 80 90 100 110 pF1KB7 RKCCYLHCGFKCVIPVKELEEGGNKDEDVSRPYPEPGWEAKCPGSSSTRCPQK :::. :: .:: ::: NP_003 LKCCMGMCGKSCVSPVKA 120 130 >>XP_011526903 (OMIM: 605161) PREDICTED: WAP four-disulf (123 aa) initn: 169 init1: 158 opt: 187 Z-score: 238.4 bits: 49.4 E(85289): 1.5e-06 Smith-Waterman score: 187; 34.8% identity (58.0% similar) in 112 aa overlap (1-108:1-108) 10 20 30 40 50 pF1KB7 MGSSSFLVLMVSLVLVT-LVAVEGVKEGIEKAGVCPADNVRCFKSDPPQCHTDQDCLGER : ..:.:.: . :.. . : :: : :.: ::.: :: :. :. : : :: :..: : XP_011 MRTQSLLLLGALLAVGSQLPAVFGRKKG-EKSGGCPPDDGPCLLSVPDQCVEDSQCPLTR 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 KCCYLHCGFKCVIPVKELEEGGNKDEDVSRPYPEPGW---EAKCPGSSSTRCPQK :::: : .:: : .. :. .... : .. : :.. :: XP_011 KCCYRACFRQCV-PRVSVKLGSCPEDQLRCLSPMNHLCHKDSDCSGKK--RCCHSACGRD 60 70 80 90 100 110 XP_011 CRDPARG 120 >>XP_011526904 (OMIM: 605161) PREDICTED: WAP four-disulf (123 aa) initn: 169 init1: 158 opt: 187 Z-score: 238.4 bits: 49.4 E(85289): 1.5e-06 Smith-Waterman score: 187; 34.8% identity (58.0% similar) in 112 aa overlap (1-108:1-108) 10 20 30 40 50 pF1KB7 MGSSSFLVLMVSLVLVT-LVAVEGVKEGIEKAGVCPADNVRCFKSDPPQCHTDQDCLGER : ..:.:.: . :.. . : :: : :.: ::.: :: :. :. : : :: :..: : XP_011 MRTQSLLLLGALLAVGSQLPAVFGRKKG-EKSGGCPPDDGPCLLSVPDQCVEDSQCPLTR 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 KCCYLHCGFKCVIPVKELEEGGNKDEDVSRPYPEPGW---EAKCPGSSSTRCPQK :::: : .:: : .. :. .... : .. : :.. :: XP_011 KCCYRACFRQCV-PRVSVKLGSCPEDQLRCLSPMNHLCHKDSDCSGKK--RCCHSACGRD 60 70 80 90 100 110 XP_011 CRDPARG 120 >>NP_663627 (OMIM: 605161) WAP four-disulfide core domai (123 aa) initn: 169 init1: 158 opt: 187 Z-score: 238.4 bits: 49.4 E(85289): 1.5e-06 Smith-Waterman score: 187; 34.8% identity (58.0% similar) in 112 aa overlap (1-108:1-108) 10 20 30 40 50 pF1KB7 MGSSSFLVLMVSLVLVT-LVAVEGVKEGIEKAGVCPADNVRCFKSDPPQCHTDQDCLGER : ..:.:.: . :.. . : :: : :.: ::.: :: :. :. : : :: :..: : NP_663 MRTQSLLLLGALLAVGSQLPAVFGRKKG-EKSGGCPPDDGPCLLSVPDQCVEDSQCPLTR 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 KCCYLHCGFKCVIPVKELEEGGNKDEDVSRPYPEPGW---EAKCPGSSSTRCPQK :::: : .:: : .. :. .... : .. : :.. :: NP_663 KCCYRACFRQCV-PRVSVKLGSCPEDQLRCLSPMNHLCHKDSDCSGKK--RCCHSACGRD 60 70 80 90 100 110 NP_663 CRDPARG 120 >>NP_002629 (OMIM: 182257) elafin preproprotein [Homo sa (117 aa) initn: 184 init1: 95 opt: 166 Z-score: 213.2 bits: 44.7 E(85289): 3.9e-05 Smith-Waterman score: 166; 42.9% identity (55.4% similar) in 56 aa overlap (20-73:61-116) 10 20 30 40 pF1KB7 MGSSSFLVLMVSLVLVTLVAVEGVKEGIE-KAGVCPADNVRCFKSDPP- : : :: . : : :: .:: .:: NP_002 GQDTVKGRVPFNGQDPVKGQVSVKGQDKVKAQEPVKGPVSTKPGSCPIILIRCAMLNPPN 40 50 60 70 80 90 50 60 70 80 90 100 pF1KB7 QCHTDQDCLGERKCCYLHCGFKCVIPVKELEEGGNKDEDVSRPYPEPGWEAKCPGSSSTR .: : :: : .::: ::. : .: NP_002 RCLKDTDCPGIKKCCEGSCGMACFVPQ 100 110 >>NP_001289790 (OMIM: 609031) eppin isoform 2 precursor (127 aa) initn: 195 init1: 115 opt: 149 Z-score: 192.1 bits: 40.9 E(85289): 0.00058 Smith-Waterman score: 149; 33.8% identity (59.2% similar) in 71 aa overlap (1-71:1-70) 10 20 30 40 50 60 pF1KB7 MGSSSFLVLMVSLVLVTLVAVEGVKEGIEKAGVCPADNVRCFKSDPPQCHTDQDCLGERK ::::..: :.: .::.. : :. . . :: .: .. : :..: ..: NP_001 MGSSGLLSLLVLFVLLANVQGPGLTDWLFPRR-CPKIREECEFQERDVCTKDRQCQDNKK 10 20 30 40 50 70 80 90 100 110 pF1KB7 CCYLHCGFKCVIPVKELEEGGNKDEDVSRPYPEPGWEAKCPGSSSTRCPQK :: . :: ::. NP_001 CCVFSCGKKCLDLKQVSLQMYAKCQKKLAPAWLIFFIGGMTRKIILAPCLSMVAARETIT 60 70 80 90 100 110 >>NP_065131 (OMIM: 609031) eppin isoform 1 precursor [Ho (133 aa) initn: 185 init1: 115 opt: 149 Z-score: 191.9 bits: 40.9 E(85289): 0.0006 Smith-Waterman score: 149; 33.8% identity (59.2% similar) in 71 aa overlap (1-71:1-70) 10 20 30 40 50 60 pF1KB7 MGSSSFLVLMVSLVLVTLVAVEGVKEGIEKAGVCPADNVRCFKSDPPQCHTDQDCLGERK ::::..: :.: .::.. : :. . . :: .: .. : :..: ..: NP_065 MGSSGLLSLLVLFVLLANVQGPGLTDWLFPRR-CPKIREECEFQERDVCTKDRQCQDNKK 10 20 30 40 50 70 80 90 100 110 pF1KB7 CCYLHCGFKCVIPVKELEEGGNKDEDVSRPYPEPGWEAKCPGSSSTRCPQK :: . :: ::. NP_065 CCVFSCGKKCLDLKQDVCEMPKETGPCLAYFLHWWYDKKDNTCSMFVYGGCQGNNNNFQS 60 70 80 90 100 110 111 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 06:01:48 2016 done: Fri Nov 4 06:01:48 2016 Total Scan time: 4.920 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]