FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7226, 453 aa 1>>>pF1KB7226 453 - 453 aa - 453 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.2433+/-0.00105; mu= 12.3404+/- 0.063 mean_var=70.3347+/-14.004, 0's: 0 Z-trim(103.4): 34 B-trim: 0 in 0/50 Lambda= 0.152929 statistics sampled from 7377 (7393) to 7377 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.594), E-opt: 0.2 (0.227), width: 16 Scan time: 3.040 The best scores are: opt bits E(32554) CCDS13211.1 BPIFB6 gene_id:128859|Hs108|chr20 ( 453) 2902 649.7 1.7e-186 CCDS13213.2 BPIFB4 gene_id:149954|Hs108|chr20 ( 614) 742 173.2 6.6e-43 CCDS13212.1 BPIFB3 gene_id:359710|Hs108|chr20 ( 476) 567 134.6 2.2e-31 CCDS13210.1 BPIFB2 gene_id:80341|Hs108|chr20 ( 458) 409 99.7 6.5e-21 CCDS13303.1 BPI gene_id:671|Hs108|chr20 ( 487) 282 71.7 1.9e-12 CCDS13304.1 LBP gene_id:3929|Hs108|chr20 ( 481) 268 68.6 1.6e-11 >>CCDS13211.1 BPIFB6 gene_id:128859|Hs108|chr20 (453 aa) initn: 2902 init1: 2902 opt: 2902 Z-score: 3461.6 bits: 649.7 E(32554): 1.7e-186 Smith-Waterman score: 2902; 100.0% identity (100.0% similar) in 453 aa overlap (1-453:1-453) 10 20 30 40 50 60 pF1KB7 MLRILCLALCSLLTGTRADPGALLRLGMDIMNQVQSAMDESHILEKMAAEAGKKQPGMKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 MLRILCLALCSLLTGTRADPGALLRLGMDIMNQVQSAMDESHILEKMAAEAGKKQPGMKP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 IKGITNLKVKDVQLPVITLNFVPGVGIFQCVSTGMTVTGKSFMGGNMEIIVALNITATNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 IKGITNLKVKDVQLPVITLNFVPGVGIFQCVSTGMTVTGKSFMGGNMEIIVALNITATNR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 LLRDEETGLPVFKSEGCEVILVNVKTNLPSNMLPKMVNKFLDSTLHKVLPGLMCPAIDAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 LLRDEETGLPVFKSEGCEVILVNVKTNLPSNMLPKMVNKFLDSTLHKVLPGLMCPAIDAV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 LVYVNRKWTNLSDPMPVGQMGTVKYVLMSAPATTASYIQLDFSPVVQQQKGKTIKLADAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 LVYVNRKWTNLSDPMPVGQMGTVKYVLMSAPATTASYIQLDFSPVVQQQKGKTIKLADAG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 EALTFPEGYAKGSSQLLLPATFLSAELALLQKSFHVNIQDTMIGELPPQTTKTLARFIPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 EALTFPEGYAKGSSQLLLPATFLSAELALLQKSFHVNIQDTMIGELPPQTTKTLARFIPE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 VAVAYPKSKPLTTQIKIKKPPKVTMKTGKSLLHLHSTLEMFAARWRSKAPMSLFLLEVHF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 VAVAYPKSKPLTTQIKIKKPPKVTMKTGKSLLHLHSTLEMFAARWRSKAPMSLFLLEVHF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 NLKVQYSVHENQLQMATSLDRLLSLSRKSSSIGNFNERELTGFITSYLEEAYIPVVNDVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 NLKVQYSVHENQLQMATSLDRLLSLSRKSSSIGNFNERELTGFITSYLEEAYIPVVNDVL 370 380 390 400 410 420 430 440 450 pF1KB7 QVGLPLPDFLAMNYNLAELDIVENALMLDLKLG ::::::::::::::::::::::::::::::::: CCDS13 QVGLPLPDFLAMNYNLAELDIVENALMLDLKLG 430 440 450 >>CCDS13213.2 BPIFB4 gene_id:149954|Hs108|chr20 (614 aa) initn: 654 init1: 240 opt: 742 Z-score: 883.8 bits: 173.2 E(32554): 6.6e-43 Smith-Waterman score: 742; 31.8% identity (70.4% similar) in 399 aa overlap (58-448:218-612) 30 40 50 60 70 80 pF1KB7 MDIMNQVQSAMDESHILEKMAAEAGKKQPGMKPIKGITNLKVKDVQLPVITLNFVPGVGI .. ..:::.:.. .. :: ... ..::::. CCDS13 GGLLGGGGLLGDGGLLGGGGVLGVLGEGGILSTVQGITGLRIVELTLPRVSVRLLPGVGV 190 200 210 220 230 240 90 100 110 120 130 140 pF1KB7 FQCVSTGMTVTGKSFMGGNMEIIVALNITATNRLLRDEETGLPVFKSEGCEVILVNVKTN . . : ....:::..: ..: : .:::: :: :. :: : . : :...: ..:.. CCDS13 YLSLYTRVAINGKSLIGF-LDIAVEVNITAKVRLTMDR-TGYPRLVIERCDTLLGGIKVK 250 260 270 280 290 300 150 160 170 180 190 200 pF1KB7 LPSNMLPKMVNKFLDSTLHKVLPGLMCPAIDAVLVYVNRKWTNLSDPMPVGQMGTVKYVL : ..::..:..... .: ::: :.:: .:.:: :: . ... .:.: .:.:.:.. CCDS13 LLRGLLPNLVDNLVNRVLADVLPDLLCPIVDVVLGLVNDQLGLVDSLIPLGILGSVQYTF 310 320 330 340 350 360 210 220 230 240 250 260 pF1KB7 MSAPATTASYIQLDFSPVVQQQKGKTIKLADAGEALT---FPEGYAKGS---SQLLLPAT : : .:. ...::.. .: . : : . :.. .:: :. ::: . :. CCDS13 SSLPLVTGEFLELDLNTLVGEAGGGLIDYPLGWPAVSPKPMPELPPMGDNTKSQLAMSAN 370 380 390 400 410 420 270 280 290 300 310 pF1KB7 FLSAELALLQK--SFHVNIQDTMIGELPPQTTKTLARFIPEVAVAYPKSKPLTTQIKIKK ::.. :.:::: .. ..: . :. :::: :: ::. .::.: ::.: :: .:.. . CCDS13 FLGSVLTLLQKQHALDLDITNGMFEELPPLTTATLGALIPKVFQQYPESCPLIIRIQVLN 430 440 450 460 470 480 320 330 340 350 360 370 pF1KB7 PPKVTMKTGKSLLHLHSTLEMFAARWRSKAPMSLFLLEVHFNLKVQYSVHENQLQMATSL ::.: .. :.:... .: :..... .. .. :..: .. ...:.. ..:.. ..: CCDS13 PPSVMLQKDKALVKVLATAEVMVSQPKD-LETTICLIDVDTEFLASFSTEGDKLMIDAKL 490 500 510 520 530 540 380 390 400 410 420 430 pF1KB7 DRLLSLSRKSSSIGNFNERELTGFITSYLEEAYIPVVNDVLQVGLPLPDFLAMNYNLAEL .. ::. ..:..:::. . .. . .. :..:..: :: :.::: .: .... :.. CCDS13 EKT-SLNLRTSNVGNFDIGLMEVLVEKIFDLAFMPAMNAVLGSGVPLPKILNIDFSNADI 550 560 570 580 590 600 440 450 pF1KB7 DIVENALMLDLKLG :..:. :.: CCDS13 DVLEDLLVLSA 610 >>CCDS13212.1 BPIFB3 gene_id:359710|Hs108|chr20 (476 aa) initn: 492 init1: 199 opt: 567 Z-score: 677.0 bits: 134.6 E(32554): 2.2e-31 Smith-Waterman score: 567; 27.8% identity (62.2% similar) in 392 aa overlap (61-448:89-472) 40 50 60 70 80 90 pF1KB7 MNQVQSAMDESHILEKMAAEAGKKQPGMKPIKGITNLKVKDVQLPVITLNFVPGVGIFQC .. ...::.... :: . :...:: :. CCDS13 SVTAVNRGLLGSGGLLGGGGLLGHGGVFGVVEELSGLKIEELTLPKVLLKLLPGFGVQLS 60 70 80 90 100 110 100 110 120 130 140 pF1KB7 VST--GMTVTGKSFMGGNMEIIVALNITATNRLLRDEETGLPVFKSEGCEVILVNVKTNL . : :: .: .:: ... . .:.:. : . . : :.. . : ..: .. .: CCDS13 LHTKVGMHCSGP--LGGLLQLAAEVNVTSRVALAVSSR-GTPILILKRCSTLLGHI--SL 120 130 140 150 160 170 150 160 170 180 190 200 pF1KB7 PSNMLPKMVNKFLDSTLHKVLPGLMCPAIDAVLVYVNRKWTNLSDPMPVGQMGTVKYVLM :..:: . ... : ::::::.::..:.:: ::. . . .: .:.:.. : CCDS13 FSGLLPTPLFGVVEQMLFKVLPGLLCPVVDSVLGVVNELLGAVLGLVSLGALGSVEFSLA 180 190 200 210 220 230 210 220 230 240 250 260 pF1KB7 SAPATTASYIQLDFSPVVQQQKGKTIKLADAGEALTFPEGYAKGSSQLLLPATFLSAELA . : . .::.::..:.:.. : : . . : .::...: .... .. CCDS13 TLPLISNQYIELDINPIVKSVAGDIIDFPKSRAPAKVPPK-KDHTSQVMVPLYLFNTTFG 240 250 260 270 280 290 270 280 290 300 310 320 pF1KB7 LLQKS--FHVNIQDTMIGELPPQTTKTLARFIPEVAVAYPKSKPLTTQIKIKKPPKVTMK ::: . . ..: .. : :: :: ..::. : . : ..... : ::.. CCDS13 LLQTNGALDMDITPELVPSDVPLTTTDLAALLPEALGKLPLHQQLLLFLRVREAPTVTLH 300 310 320 330 340 350 330 340 350 360 370 380 pF1KB7 TGKSLLHLHSTLEMFAARWRSKAPMSLFLLEVHFNLKVQYSVHENQLQMATSLDRLLSLS . :.:. : ...... .. .: ::: :. .....: . ..:... ::.:: :.. CCDS13 NKKALVSLPANIHVLFYVPKG-TPESLFELNSVMTVRAQLAPSATKLHISLSLERL-SVK 360 370 380 390 400 410 390 400 410 420 430 440 pF1KB7 RKSSSIGNFNERELTGFITSYLEEAYIPVVNDVLQVGLPLPDFLAMNYNLAELDIVENAL :: :. .: ... . .: : .: .:.::.::: : .:.. . :.:::::. CCDS13 VASSFTHAFDGSRLEEWLSHVVGAVYAPKLNVALDVGIPLPKVLNINFSNSVLEIVENAV 420 430 440 450 460 470 450 pF1KB7 MLDLKLG .: CCDS13 VLTVAS >>CCDS13210.1 BPIFB2 gene_id:80341|Hs108|chr20 (458 aa) initn: 308 init1: 135 opt: 409 Z-score: 488.9 bits: 99.7 E(32554): 6.5e-21 Smith-Waterman score: 409; 23.9% identity (60.3% similar) in 451 aa overlap (5-448:9-450) 10 20 30 40 50 pF1KB7 MLRILCLALCSLLTGTRADPGALLRLGMDIMNQVQSAMDESHILEKMAAEAGKKQP : ::: ..:. . ::...::. .. : : . .. . . . . . . CCDS13 MAWASRLGLLLALLLPVVGA-STPGTVVRLNKAALSYV-SEIGKAPLQRALQVTVPHFLD 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 GMKPIKGITNLKVKDVQLPVITLNFVPGVGIFQCVSTGMTVTGKSFMGGN-MEIIVALNI : ... .:..: . :.:. : :. .....: : : . . .:. . ... CCDS13 WSGEALQPTRIRILNVHVPRLHLKFIAGFGVRLLAAANFTF--KVFRAPEPLELTLPVEL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 TATNRLLRDEETGLPVFKSEGCEVILVNVKTNLPSNMLPKMVNKFLDSTLHKVLPGLMCP : .:. .. :: . .: .. ... :: . . .... .. :: . .: CCDS13 LADTRVTQSS-IRTPVVSISACSLFSGHANEFDGSNSTSHALLVLVQKHIKAVLSNKLCL 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB7 AIDAVLVYVNRKWTNLSDPMPVGQMGTVKYVLMSAPATTASYIQLDFSPVVQQQKGKTIK .:. .. :: . .: ::: . ..: ..:.:..:..::.:. . :. :: : CCDS13 SISNLVQGVNVHLGTLIGLNPVGPESQIRYSMVSVPTVTSDYISLEVNAVLFLL-GKPII 180 190 200 210 220 230 240 250 260 270 280 pF1KB7 LADAGEALTFPEGYA-KGSSQLL-LPATFLSAELALLQKSFHVNIQDTMIGELPPQ---- : . ...:. . .:: . : .... : ::::. .:.. : :.: . CCDS13 LPTDATPFVLPRHVGTEGSMATVGLSQQLFDSALLLLQKAGALNLDIT--GQLRSDDNLL 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB7 TTKTLARFIPEVAVAYPKSKPLTTQIKIKKPPKVTMKTGKSLLHLHSTLEMFAARWRSKA .:..:.:.::::: .:. :.. .... : . ..:... :.:. .:..:. ..: CCDS13 NTSALGRLIPEVARQFPEPMPVVLKVRLGATPVAMLHTNNATLRLQPFVEVLATA-SNSA 300 310 320 330 340 350 350 360 370 380 390 400 pF1KB7 PMSLFLLEVHFNLKVQYSVHENQLQMATSLDRLLSLSRKSSSIGNFNERELTGFITSYLE .::: :.: ::..: :: . .:: .::. ..:. ::..: .. .. .. . .: CCDS13 FQSLFSLDVVVNLRLQLSVSKVKLQGTTSVLGDVQLTVASSNVGFIDTDQVRTLMGTVFE 360 370 380 390 400 410 410 420 430 440 450 pF1KB7 EAYIPVVNDVLQVGLPLPDFLAMNYNLAELDIVENALMLDLKLG . . .: .: .:. :: . ..: :. . :. ... CCDS13 KPLLDHLNALLAMGIALPGVVNLHYVAPEIFVYEGYVVISSGLFYQS 420 430 440 450 >>CCDS13303.1 BPI gene_id:671|Hs108|chr20 (487 aa) initn: 200 init1: 83 opt: 282 Z-score: 337.0 bits: 71.7 E(32554): 1.9e-12 Smith-Waterman score: 345; 23.3% identity (58.5% similar) in 446 aa overlap (7-427:19-459) 10 20 30 40 pF1KB7 MLRILCLALCSLLTGTRA--DPGALLRL---GMDIMNQVQSAMDESHI ..: .. :.. : .::...:. :.: .: .: ... CCDS13 MRENMARGPCNAPRWASLMVLVAIGTAVTAAVNPGVVVRISQKGLDYASQQGTAALQKE- 10 20 30 40 50 50 60 70 80 90 pF1KB7 LEKMAAEAGKKQPGMKPI-KG---ITNLKVKDVQLPVITLNFVPGVGI-FQCVSTGMTVT :... . . .: . :: . .. ... ::: ...::.::. :. .... .. CCDS13 LKRIKIPDYSDSFKIKHLGKGHYSFYSMDIREFQLPSSQISMVPNVGLKFSISNANIKIS 60 70 80 90 100 110 100 110 120 130 140 150 pF1KB7 GK-----SF--MGGNMEI-IVALNITATNRLLRDEETGLPVFKSEGCEVILVNVKTNLPS :: : :.::... : ...:.: .: . .: :.. .: . .:.... . CCDS13 GKWKAQKRFLKMSGNFDLSIEGMSISADLKLGSNPTSGKPTITCSSCSSHINSVHVHISK 120 130 140 150 160 170 160 170 180 190 200 pF1KB7 N---MLPKMVNKFLDSTLHKVLPGLMCPAI-DAVLVYVNRKWTNLSDPMPVGQMGTVKYV . : .. .: ..:.:.. . . .: . ..: .. . .: . ... ..: CCDS13 SKVGWLIQLFHKKIESALRNKMNSQVCEKVTNSVSSELQPYFQTLPVMTKIDSVAGINYG 180 190 200 210 220 230 210 220 230 240 250 260 pF1KB7 LMSAPATTASYIQLDFSPVVQQQKGKTIKLADAGEALTFPEGYAKGSSQLLLPATFLSAE :.. ::::: ...... ... .. : .. :: .. . : : .: CCDS13 LVAPPATTAETLDVQMKGEFYSENHHNPP-PFAPPVMEFPAAHDRMVYLGLSDYFFNTAG 240 250 260 270 280 290 270 280 290 300 310 320 pF1KB7 LALLQKS-FHVNIQDTMIGELPP--QTTKTLARFIPEVAVAYPKSKPLTTQIKIKKPPKV :. . . ......: :: . ::: .. :.:::: .:. : . ... . ::.. CCDS13 LVYQEAGVLKMTLRDDMIPKESKFRLTTKFFGTFLPEVAKKFPNMK-IQIHVSASTPPHL 300 310 320 330 340 350 330 340 350 360 370 380 pF1KB7 TMKTGKSLLHLHSTLEMFAARWRSKAPMSLFLLEVHFNLKVQYSVHENQLQMATSLDRLL ... .. .. ::. :. ::::. .: . ... :.. :.: .::::: CCDS13 SVQPTGLTFYPAVDVQAFAVLPNSSLA-SLFLIGMHTTGSMEVSAESNRLVGELKLDRLL 360 370 380 390 400 410 390 400 410 420 430 440 pF1KB7 SLSRKSSSIGNFNERELTGFITSYLEEAYIPVVNDVLQVGLPLPDFLAMNYNLAELDIVE : : :.:: : . : ... . .: ::. :: :.::: CCDS13 -LELKHSNIGPFPVELLQDIMNYIVPILVLPRVNEKLQKGFPLPTPARVQLYNVVLQPHQ 420 430 440 450 460 470 450 pF1KB7 NALMLDLKLG CCDS13 NFLLFGADVVYK 480 >>CCDS13304.1 LBP gene_id:3929|Hs108|chr20 (481 aa) initn: 138 init1: 97 opt: 268 Z-score: 320.4 bits: 68.6 E(32554): 1.6e-11 Smith-Waterman score: 292; 22.7% identity (55.7% similar) in 449 aa overlap (4-427:12-451) 10 20 30 40 pF1KB7 MLRILCLALCSLLTGTRADPGALLRL---GMDIMNQVQSAMDESHILE-KMA .: : : : . :.:: . :. :.. : .:..:. . CCDS13 MGALARALPSILLALLLTSTPEALGANPGLVARITDKGLQYAAQEGLLALQSELLRITLP 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB7 AEAGK-KQPGM-KPIKGITNLKVKDVQLPVITLNFVPGVGIFQCVS-TGMTVTG-----K .: . : . . . .:.... .: .: ::: :. .: ... : : : CCDS13 DFTGDLRIPHVGRGRYEFHSLNIHSCELLHSALRPVPGQGLSLSISDSSIRVQGRWKVRK 70 80 90 100 110 120 110 120 130 140 150 pF1KB7 SF--MGGNMEIIVALNITATNRLLRDEETGLPVFKSEGCEVILVNVKTNLPSNM--LPKM :: . :.... : ..: :: .: .: :. . .: ...:.... ... : .. CCDS13 SFFKLQGSFDVSVKGISISVNLLLGSESSGRPTVTASSCSSDIADVEVDMSGDLGWLLNL 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB7 VNKFLDSTLHKVLPGLMCPAID-AVLVYVNRKWTNLSDPMPVGQMGTVKYVLMSAPATTA .. ..: ..::: . .: :. .: .. .: . ... . : :. :: .:: CCDS13 FHNQIESKFQKVLESRICEMIQKSVSSDLQPYLQTLPVTTEIDSFADIDYSLVEAPRATA 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB7 SYIQLDFSPVVQQQKGKT-IKLADAGEALTFPEGYAKGSSQLLLPATFLSAELALLQKSF ..... :. . ... .. . : : ....:: . : . .: .: :. .... CCDS13 QMLEVMFKGEIFHRNHRSPVTLLAA--VMSLPEEHNKMVYFAISDYVFNTASLVYHEEGY 250 260 270 280 290 280 290 300 310 320 pF1KB7 -HVNIQDTMIGELPPQ-----TTKTLARFIPEVAVAYPKSKPLTTQIKIKKPPKVTMKTG . .: : :: ::. :::.. :.:..: ::. . : : .. . : .... : CCDS13 LNFSITDDMI---PPDSNIRLTTKSFRPFVPRLARLYPNMN-LELQGSVPSAPLLNFSPG 300 310 320 330 340 350 330 340 350 360 370 380 pF1KB7 KSLLHLHSTLEMFAARWRS-KAPMSLFLLEVHFNLKVQYSVHENQLQMATSLDRLLSLSR . . . .. :. : : :. : : : :... . . ... . .. .. CCDS13 NLSVDPYMEIDAFVLLPSSSKEPV--FRLSVATNVSATLTFNTSKITGFLKPGKV-KVEL 360 370 380 390 400 410 390 400 410 420 430 440 pF1KB7 KSSSIGNFNERELTGFITSYLEEAYIPVVNDVLQVGLPLPDFLAMNYNLAELDIVENALM : :..: :: . : .... :. ... : :: : :.::: CCDS13 KESKVGLFNAELLEALLNYYILNTFYPKFNDKLAEGFPLPLLKRVQLYDLGLQIHKDFLF 420 430 440 450 460 470 450 pF1KB7 LDLKLG CCDS13 LGANVQYMRV 480 453 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 06:06:46 2016 done: Fri Nov 4 06:06:46 2016 Total Scan time: 3.040 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]