FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7227, 220 aa 1>>>pF1KB7227 220 - 220 aa - 220 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2845+/-0.000385; mu= 14.1081+/- 0.024 mean_var=64.6889+/-13.108, 0's: 0 Z-trim(112.5): 49 B-trim: 516 in 1/55 Lambda= 0.159463 statistics sampled from 21413 (21462) to 21413 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.643), E-opt: 0.2 (0.252), width: 16 Scan time: 5.700 The best scores are: opt bits E(85289) XP_011524123 (OMIM: 607051) PREDICTED: stAR-relate ( 220) 1477 348.4 5.5e-96 NP_631910 (OMIM: 607051) stAR-related lipid transf ( 220) 1477 348.4 5.5e-96 XP_016881043 (OMIM: 607051) PREDICTED: stAR-relate ( 138) 943 225.4 3.6e-59 XP_016881042 (OMIM: 607051) PREDICTED: stAR-relate ( 161) 901 215.8 3.3e-56 XP_016881041 (OMIM: 607051) PREDICTED: stAR-relate ( 161) 901 215.8 3.3e-56 NP_871629 (OMIM: 607050) stAR-related lipid transf ( 213) 483 119.7 3.7e-27 NP_631903 (OMIM: 607049) stAR-related lipid transf ( 205) 379 95.8 5.7e-20 NP_001294985 (OMIM: 607049) stAR-related lipid tra ( 205) 379 95.8 5.7e-20 XP_016878128 (OMIM: 607050) PREDICTED: stAR-relate ( 192) 378 95.5 6.4e-20 XP_006721709 (OMIM: 607048) PREDICTED: stAR-relate ( 412) 281 73.4 6.3e-13 NP_001159410 (OMIM: 607048) stAR-related lipid tra ( 427) 281 73.4 6.5e-13 NP_006795 (OMIM: 607048) stAR-related lipid transf ( 445) 281 73.4 6.8e-13 XP_016879530 (OMIM: 607048) PREDICTED: stAR-relate ( 445) 281 73.4 6.8e-13 NP_001159409 (OMIM: 607048) stAR-related lipid tra ( 445) 281 73.4 6.8e-13 NP_000340 (OMIM: 201710,600617) steroidogenic acut ( 285) 275 71.9 1.2e-12 XP_016864532 (OMIM: 607049) PREDICTED: stAR-relate ( 107) 255 67.1 1.3e-11 XP_016864530 (OMIM: 607049) PREDICTED: stAR-relate ( 107) 255 67.1 1.3e-11 NP_001294989 (OMIM: 607049) stAR-related lipid tra ( 107) 255 67.1 1.3e-11 XP_016864531 (OMIM: 607049) PREDICTED: stAR-relate ( 107) 255 67.1 1.3e-11 XP_016864533 (OMIM: 607049) PREDICTED: stAR-relate ( 123) 255 67.1 1.4e-11 NP_001294990 (OMIM: 607049) stAR-related lipid tra ( 123) 255 67.1 1.4e-11 NP_001294988 (OMIM: 607049) stAR-related lipid tra ( 123) 255 67.1 1.4e-11 XP_011522515 (OMIM: 607048) PREDICTED: stAR-relate ( 468) 243 64.7 3e-10 XP_011522512 (OMIM: 607048) PREDICTED: stAR-relate ( 501) 243 64.7 3.2e-10 XP_011522513 (OMIM: 607048) PREDICTED: stAR-relate ( 501) 243 64.7 3.2e-10 XP_006716455 (OMIM: 201710,600617) PREDICTED: ster ( 288) 191 52.6 8e-07 NP_001294987 (OMIM: 607049) stAR-related lipid tra ( 159) 187 51.5 9.2e-07 NP_001294986 (OMIM: 607049) stAR-related lipid tra ( 159) 187 51.5 9.2e-07 XP_016864537 (OMIM: 614315) PREDICTED: acyl-coenzy ( 361) 149 43.0 0.00078 XP_016864536 (OMIM: 614315) PREDICTED: acyl-coenzy ( 532) 149 43.1 0.0011 NP_570123 (OMIM: 614315) acyl-coenzyme A thioester ( 555) 149 43.1 0.0011 XP_016864534 (OMIM: 614315) PREDICTED: acyl-coenzy ( 566) 149 43.1 0.0011 NP_671517 (OMIM: 606803) acyl-coenzyme A thioester ( 594) 149 43.1 0.0012 NP_056362 (OMIM: 606803) acyl-coenzyme A thioester ( 607) 147 42.6 0.0017 >>XP_011524123 (OMIM: 607051) PREDICTED: stAR-related li (220 aa) initn: 1477 init1: 1477 opt: 1477 Z-score: 1844.2 bits: 348.4 E(85289): 5.5e-96 Smith-Waterman score: 1477; 100.0% identity (100.0% similar) in 220 aa overlap (1-220:1-220) 10 20 30 40 50 60 pF1KB7 MDFKAIAQQTAQEVLGYNRDTSGWKVVKTSKKITVSSKASRKFHGNLYRVEGIIPESPAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MDFKAIAQQTAQEVLGYNRDTSGWKVVKTSKKITVSSKASRKFHGNLYRVEGIIPESPAK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 LSDFLYQTGDRITWDKSLQVYNMVHRIDSDTFICHTITQSFAVGSISPRDFIDLVYIKRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSDFLYQTGDRITWDKSLQVYNMVHRIDSDTFICHTITQSFAVGSISPRDFIDLVYIKRY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 EGNMNIISSKSVDFPEYPPSSNYIRGYNHPCGFVCSPMEENPAYSKLVMFVQTEMRGKLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EGNMNIISSKSVDFPEYPPSSNYIRGYNHPCGFVCSPMEENPAYSKLVMFVQTEMRGKLS 130 140 150 160 170 180 190 200 210 220 pF1KB7 PSIIEKTMPSNLVNFILNAKDGIKAHRTPSRRGFHHNSHS :::::::::::::::::::::::::::::::::::::::: XP_011 PSIIEKTMPSNLVNFILNAKDGIKAHRTPSRRGFHHNSHS 190 200 210 220 >>NP_631910 (OMIM: 607051) stAR-related lipid transfer p (220 aa) initn: 1477 init1: 1477 opt: 1477 Z-score: 1844.2 bits: 348.4 E(85289): 5.5e-96 Smith-Waterman score: 1477; 100.0% identity (100.0% similar) in 220 aa overlap (1-220:1-220) 10 20 30 40 50 60 pF1KB7 MDFKAIAQQTAQEVLGYNRDTSGWKVVKTSKKITVSSKASRKFHGNLYRVEGIIPESPAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_631 MDFKAIAQQTAQEVLGYNRDTSGWKVVKTSKKITVSSKASRKFHGNLYRVEGIIPESPAK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 LSDFLYQTGDRITWDKSLQVYNMVHRIDSDTFICHTITQSFAVGSISPRDFIDLVYIKRY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_631 LSDFLYQTGDRITWDKSLQVYNMVHRIDSDTFICHTITQSFAVGSISPRDFIDLVYIKRY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 EGNMNIISSKSVDFPEYPPSSNYIRGYNHPCGFVCSPMEENPAYSKLVMFVQTEMRGKLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_631 EGNMNIISSKSVDFPEYPPSSNYIRGYNHPCGFVCSPMEENPAYSKLVMFVQTEMRGKLS 130 140 150 160 170 180 190 200 210 220 pF1KB7 PSIIEKTMPSNLVNFILNAKDGIKAHRTPSRRGFHHNSHS :::::::::::::::::::::::::::::::::::::::: NP_631 PSIIEKTMPSNLVNFILNAKDGIKAHRTPSRRGFHHNSHS 190 200 210 220 >>XP_016881043 (OMIM: 607051) PREDICTED: stAR-related li (138 aa) initn: 943 init1: 943 opt: 943 Z-score: 1183.3 bits: 225.4 E(85289): 3.6e-59 Smith-Waterman score: 943; 100.0% identity (100.0% similar) in 138 aa overlap (83-220:1-138) 60 70 80 90 100 110 pF1KB7 IIPESPAKLSDFLYQTGDRITWDKSLQVYNMVHRIDSDTFICHTITQSFAVGSISPRDFI :::::::::::::::::::::::::::::: XP_016 MVHRIDSDTFICHTITQSFAVGSISPRDFI 10 20 30 120 130 140 150 160 170 pF1KB7 DLVYIKRYEGNMNIISSKSVDFPEYPPSSNYIRGYNHPCGFVCSPMEENPAYSKLVMFVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLVYIKRYEGNMNIISSKSVDFPEYPPSSNYIRGYNHPCGFVCSPMEENPAYSKLVMFVQ 40 50 60 70 80 90 180 190 200 210 220 pF1KB7 TEMRGKLSPSIIEKTMPSNLVNFILNAKDGIKAHRTPSRRGFHHNSHS :::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TEMRGKLSPSIIEKTMPSNLVNFILNAKDGIKAHRTPSRRGFHHNSHS 100 110 120 130 >>XP_016881042 (OMIM: 607051) PREDICTED: stAR-related li (161 aa) initn: 901 init1: 901 opt: 901 Z-score: 1130.1 bits: 215.8 E(85289): 3.3e-56 Smith-Waterman score: 962; 73.2% identity (73.2% similar) in 220 aa overlap (1-220:1-161) 10 20 30 40 50 60 pF1KB7 MDFKAIAQQTAQEVLGYNRDTSGWKVVKTSKKITVSSKASRKFHGNLYRVEGIIPESPAK :::::::::::::::::::::::::::::: XP_016 MDFKAIAQQTAQEVLGYNRDTSGWKVVKTS------------------------------ 10 20 30 70 80 90 100 110 120 pF1KB7 LSDFLYQTGDRITWDKSLQVYNMVHRIDSDTFICHTITQSFAVGSISPRDFIDLVYIKRY ::::::::::::::::::::::::::::::: XP_016 -----------------------------DTFICHTITQSFAVGSISPRDFIDLVYIKRY 40 50 60 130 140 150 160 170 180 pF1KB7 EGNMNIISSKSVDFPEYPPSSNYIRGYNHPCGFVCSPMEENPAYSKLVMFVQTEMRGKLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGNMNIISSKSVDFPEYPPSSNYIRGYNHPCGFVCSPMEENPAYSKLVMFVQTEMRGKLS 70 80 90 100 110 120 190 200 210 220 pF1KB7 PSIIEKTMPSNLVNFILNAKDGIKAHRTPSRRGFHHNSHS :::::::::::::::::::::::::::::::::::::::: XP_016 PSIIEKTMPSNLVNFILNAKDGIKAHRTPSRRGFHHNSHS 130 140 150 160 >>XP_016881041 (OMIM: 607051) PREDICTED: stAR-related li (161 aa) initn: 901 init1: 901 opt: 901 Z-score: 1130.1 bits: 215.8 E(85289): 3.3e-56 Smith-Waterman score: 962; 73.2% identity (73.2% similar) in 220 aa overlap (1-220:1-161) 10 20 30 40 50 60 pF1KB7 MDFKAIAQQTAQEVLGYNRDTSGWKVVKTSKKITVSSKASRKFHGNLYRVEGIIPESPAK :::::::::::::::::::::::::::::: XP_016 MDFKAIAQQTAQEVLGYNRDTSGWKVVKTS------------------------------ 10 20 30 70 80 90 100 110 120 pF1KB7 LSDFLYQTGDRITWDKSLQVYNMVHRIDSDTFICHTITQSFAVGSISPRDFIDLVYIKRY ::::::::::::::::::::::::::::::: XP_016 -----------------------------DTFICHTITQSFAVGSISPRDFIDLVYIKRY 40 50 60 130 140 150 160 170 180 pF1KB7 EGNMNIISSKSVDFPEYPPSSNYIRGYNHPCGFVCSPMEENPAYSKLVMFVQTEMRGKLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGNMNIISSKSVDFPEYPPSSNYIRGYNHPCGFVCSPMEENPAYSKLVMFVQTEMRGKLS 70 80 90 100 110 120 190 200 210 220 pF1KB7 PSIIEKTMPSNLVNFILNAKDGIKAHRTPSRRGFHHNSHS :::::::::::::::::::::::::::::::::::::::: XP_016 PSIIEKTMPSNLVNFILNAKDGIKAHRTPSRRGFHHNSHS 130 140 150 160 >>NP_871629 (OMIM: 607050) stAR-related lipid transfer p (213 aa) initn: 475 init1: 336 opt: 483 Z-score: 608.5 bits: 119.7 E(85289): 3.7e-27 Smith-Waterman score: 483; 34.4% identity (65.1% similar) in 209 aa overlap (1-204:1-209) 10 20 30 40 50 pF1KB7 MDFKAIAQQT---AQEVLGYNRDTSGWKVVKTSKKITVSSKASRKFHGNLYRVEGIIPES :: ::.. :...: : :::.:::. . .. ..:: . : .: ::::: :::. . NP_871 MDPALAAQMSEAVAEKMLQYRRDTAGWKICREGNGVSVSWRPSVEFPGNLYRGEGIVYGT 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 PAKLSDFLYQT--GDRITWDKSLQVYNMVHRIDSDTFICHTITQSFAVGSISPRDFIDLV .. : . . : :. ::... ..... : . . .: : : :. ::::::.::: NP_871 LEEVWDCVKPAVGGLRVKWDENVTGFEIIQSITDTLCVSRTSTPSAAMKLISPRDFVDLV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 YIKRYEGNMNIISSKSVDFPEYPPSSNYIRGYNHPCGFVCSPMEENPAYSKLVMFVQTEM .:::: . .. :. : ::. ...::.::::: : :. .:. ..:: : .:.. NP_871 LVKRYEDGTISSNATHVEHPLCPPKPGFVRGFNHPCGCFCEPLPGEPTKTNLVTFFHTDL 130 140 150 160 170 180 180 190 200 210 220 pF1KB7 RGKLSPSIIEKTMPSNLVNFILNAKDGIKAHRTPSRRGFHHNSHS : : ..... .: ... : : . ..: NP_871 SGYLPQNVVDSFFPRSMTRFYANLQKAVKQFHE 190 200 210 >>NP_631903 (OMIM: 607049) stAR-related lipid transfer p (205 aa) initn: 324 init1: 203 opt: 379 Z-score: 479.5 bits: 95.8 E(85289): 5.7e-20 Smith-Waterman score: 379; 29.7% identity (63.6% similar) in 195 aa overlap (2-195:6-197) 10 20 30 40 50 pF1KB7 MDFKAIAQQTAQEVLGYNR-DTSGWKVVKTSKKITVSSKASRKFHGNLYRVEGIIP : ..: . . .. :. . . :.:.: .: .:: : :..:.: ::...:.: NP_631 MEGLSDVASFATKLKNTLIQYHSIEEDKWRVAKKTKDVTVWRKPSEEFNGYLYKAQGVID 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 ESPAKLSDFLYQTGDRITWDKSLQVYNMVHRIDSDTFICHTITQSFAVGSISPRDFIDLV . .. : . :. ::. . .... .. . . . : . . ::::.:.:. NP_631 DLVYSIIDHIRPGPCRLDWDSLMTSLDILENFEENCCVMRYTTAGQLWNIISPREFVDFS 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 YIKRYEGNMNIISSKSVDFPEYPPSSNYIRGYNHPCGFVCSPMEENPAYSKLVMFVQTEM : :. .. . . :.:. : : ...::::::::. : :...:: : :. ..::.. NP_631 YTVGYKEGL-LSCGISLDWDEKRP--EFVRGYNHPCGWFCVPLKDNPNQSLLTGYIQTDL 130 140 150 160 170 180 190 200 210 220 pF1KB7 RGKLSPSIIEKTMPSNLVNFILNAKDGIKAHRTPSRRGFHHNSHS :: . : .. .: :.:.:: NP_631 RGMIPQSAVDTAMASTLTNFYGDLRKAL 180 190 200 >>NP_001294985 (OMIM: 607049) stAR-related lipid transfe (205 aa) initn: 324 init1: 203 opt: 379 Z-score: 479.5 bits: 95.8 E(85289): 5.7e-20 Smith-Waterman score: 379; 29.7% identity (63.6% similar) in 195 aa overlap (2-195:6-197) 10 20 30 40 50 pF1KB7 MDFKAIAQQTAQEVLGYNR-DTSGWKVVKTSKKITVSSKASRKFHGNLYRVEGIIP : ..: . . .. :. . . :.:.: .: .:: : :..:.: ::...:.: NP_001 MEGLSDVASFATKLKNTLIQYHSIEEDKWRVAKKTKDVTVWRKPSEEFNGYLYKAQGVID 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 ESPAKLSDFLYQTGDRITWDKSLQVYNMVHRIDSDTFICHTITQSFAVGSISPRDFIDLV . .. : . :. ::. . .... .. . . . : . . ::::.:.:. NP_001 DLVYSIIDHIRPGPCRLDWDSLMTSLDILENFEENCCVMRYTTAGQLWNIISPREFVDFS 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 YIKRYEGNMNIISSKSVDFPEYPPSSNYIRGYNHPCGFVCSPMEENPAYSKLVMFVQTEM : :. .. . . :.:. : : ...::::::::. : :...:: : :. ..::.. NP_001 YTVGYKEGL-LSCGISLDWDEKRP--EFVRGYNHPCGWFCVPLKDNPNQSLLTGYIQTDL 130 140 150 160 170 180 190 200 210 220 pF1KB7 RGKLSPSIIEKTMPSNLVNFILNAKDGIKAHRTPSRRGFHHNSHS :: . : .. .: :.:.:: NP_001 RGMIPQSAVDTAMASTLTNFYGDLRKAL 180 190 200 >>XP_016878128 (OMIM: 607050) PREDICTED: stAR-related li (192 aa) initn: 358 init1: 336 opt: 378 Z-score: 478.7 bits: 95.5 E(85289): 6.4e-20 Smith-Waterman score: 378; 31.7% identity (63.9% similar) in 183 aa overlap (26-204:6-188) 10 20 30 40 50 pF1KB7 MDFKAIAQQTAQEVLGYNRDTSGWKVVKTSKKIT--VSSKASRKFHGNLYRVEGIIPESP :.. . ::: ... .: .: . :: :::. . XP_016 MVHLLVLRYNLKITSLIDALGSNSFSCSRYRGEGIVYGTL 10 20 30 40 60 70 80 90 100 110 pF1KB7 AKLSDFLYQT--GDRITWDKSLQVYNMVHRIDSDTFICHTITQSFAVGSISPRDFIDLVY .. : . . : :. ::... ..... : . . .: : : :. ::::::.::: XP_016 EEVWDCVKPAVGGLRVKWDENVTGFEIIQSITDTLCVSRTSTPSAAMKLISPRDFVDLVL 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB7 IKRYEGNMNIISSKSVDFPEYPPSSNYIRGYNHPCGFVCSPMEENPAYSKLVMFVQTEMR .:::: . .. :. : ::. ...::.::::: : :. .:. ..:: : .:.. XP_016 VKRYEDGTISSNATHVEHPLCPPKPGFVRGFNHPCGCFCEPLPGEPTKTNLVTFFHTDLS 110 120 130 140 150 160 180 190 200 210 220 pF1KB7 GKLSPSIIEKTMPSNLVNFILNAKDGIKAHRTPSRRGFHHNSHS : : ..... .: ... : : . ..: XP_016 GYLPQNVVDSFFPRSMTRFYANLQKAVKQFHE 170 180 190 >>XP_006721709 (OMIM: 607048) PREDICTED: stAR-related li (412 aa) initn: 183 init1: 86 opt: 281 Z-score: 353.0 bits: 73.4 E(85289): 6.3e-13 Smith-Waterman score: 281; 24.2% identity (62.1% similar) in 182 aa overlap (24-203:226-405) 10 20 30 40 50 pF1KB7 MDFKAIAQQTAQEVLGYNRDTSGWKVVKTSKKITVSSKASRKFHGNLYRVEGI :: :... . :::. . .. . XP_006 KSFSAQEREYIRQGKEATAVVDQILAQEENWKFEKNNEYGDTVYTIEVPFHGKTFILKTF 200 210 220 230 240 250 60 70 80 90 100 110 pF1KB7 IPESPAKL--SDFLYQTGDRITWDKSLQVYNMVHRIDSDTFICHTITQSFAVGSISPRDF .: ::.: .. . : . :.:.. . ....:....:.: . .. . : : .::::: XP_006 LP-CPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAAGGVVSPRDF 260 270 280 290 300 310 120 130 140 150 160 170 pF1KB7 IDLVYIKRYEGNMNIISSKSVDFPEYPPSSNYIRGYNHPCGFVCSPMEENPAYSKLVMFV ... :.: . . . :. ... ::. .:.:: : : ::. :: .: .. XP_006 VNVRRIERRRDRY-LSSGIATSHSAKPPTHKYVRGENGPGGFIVLKSASNPRVCTFVWIL 320 330 340 350 360 370 180 190 200 210 220 pF1KB7 QTEMRGKLSPSIIEKTMPSNLVNFILNAKDGIKAHRTPSRRGFHHNSHS .:...:.: .:.... ... .: .. .. : XP_006 NTDLKGRLPRYLIHQSLAATMFEFAFHLRQRISELGARA 380 390 400 410 220 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 09:44:01 2016 done: Sat Nov 5 09:44:02 2016 Total Scan time: 5.700 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]