FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7231, 434 aa 1>>>pF1KB7231 434 - 434 aa - 434 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9417+/-0.000409; mu= 19.1423+/- 0.025 mean_var=63.3169+/-12.487, 0's: 0 Z-trim(111.4): 65 B-trim: 0 in 0/55 Lambda= 0.161181 statistics sampled from 19970 (20040) to 19970 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.604), E-opt: 0.2 (0.235), width: 16 Scan time: 7.410 The best scores are: opt bits E(85289) NP_817124 (OMIM: 616768,616780) tubulin beta-8 cha ( 444) 2691 634.8 1.3e-181 NP_006079 (OMIM: 602660) tubulin beta-4B chain [Ho ( 445) 2533 598.0 1.6e-170 NP_821133 (OMIM: 156610,191130,615771) tubulin bet ( 444) 2515 593.8 2.8e-169 NP_821080 (OMIM: 610031,612850) tubulin beta-2B ch ( 445) 2513 593.4 3.9e-169 NP_001276058 (OMIM: 602662) tubulin beta-4A chain ( 444) 2512 593.2 4.6e-169 NP_006078 (OMIM: 602662) tubulin beta-4A chain iso ( 444) 2512 593.2 4.6e-169 NP_001276056 (OMIM: 602662) tubulin beta-4A chain ( 489) 2512 593.2 4.9e-169 NP_001276052 (OMIM: 602662) tubulin beta-4A chain ( 495) 2512 593.2 5e-169 NP_001060 (OMIM: 615101,615763) tubulin beta-2A ch ( 445) 2498 589.9 4.4e-168 NP_006077 (OMIM: 600638,602661,614039) tubulin bet ( 450) 2423 572.5 7.8e-163 NP_001280141 (OMIM: 156610,191130,615771) tubulin ( 464) 2417 571.1 2.1e-162 NP_001290453 (OMIM: 615103) tubulin beta-6 chain i ( 446) 2407 568.7 1e-161 NP_115914 (OMIM: 615103) tubulin beta-6 chain isof ( 446) 2407 568.7 1e-161 XP_011517761 (OMIM: 616768,616780) PREDICTED: tubu ( 372) 2244 530.8 2.3e-150 NP_001280143 (OMIM: 156610,191130,615771) tubulin ( 400) 2225 526.4 5.2e-149 NP_110400 (OMIM: 612901,613112) tubulin beta-1 cha ( 451) 2154 509.9 5.3e-144 NP_001280144 (OMIM: 156610,191130,615771) tubulin ( 372) 2126 503.3 4.2e-142 NP_001280145 (OMIM: 156610,191130,615771) tubulin ( 372) 2126 503.3 4.2e-142 NP_001276060 (OMIM: 602662) tubulin beta-4A chain ( 372) 2116 501.0 2.1e-141 NP_001276059 (OMIM: 602662) tubulin beta-4A chain ( 372) 2116 501.0 2.1e-141 NP_001184110 (OMIM: 600638,602661,614039) tubulin ( 378) 2063 488.7 1.1e-137 NP_001290456 (OMIM: 615103) tubulin beta-6 chain i ( 374) 2053 486.4 5.4e-137 XP_016883574 (OMIM: 612901,613112) PREDICTED: tubu ( 429) 2022 479.2 8.9e-135 XP_016871682 (OMIM: 616768,616780) PREDICTED: tubu ( 332) 1983 470.1 3.9e-132 XP_016871681 (OMIM: 616768,616780) PREDICTED: tubu ( 332) 1983 470.1 3.9e-132 NP_001297244 (OMIM: 615101,615763) tubulin beta-2A ( 360) 1983 470.1 4.1e-132 NP_001290455 (OMIM: 615103) tubulin beta-6 chain i ( 409) 1929 457.6 2.8e-128 NP_001290457 (OMIM: 615103) tubulin beta-6 chain i ( 381) 1927 457.1 3.6e-128 XP_011517762 (OMIM: 616768,616780) PREDICTED: tubu ( 291) 1630 387.9 1.8e-107 NP_001290458 (OMIM: 615103) tubulin beta-6 chain i ( 300) 1608 382.8 6.4e-106 NP_001290459 (OMIM: 615103) tubulin beta-6 chain i ( 300) 1608 382.8 6.4e-106 NP_006073 (OMIM: 602530) tubulin alpha-1B chain [H ( 451) 957 231.6 3.3e-60 NP_005991 (OMIM: 191110,616208) tubulin alpha-4A c ( 448) 952 230.4 7.3e-60 NP_001257328 (OMIM: 602529,611603) tubulin alpha-1 ( 451) 949 229.7 1.2e-59 NP_006000 (OMIM: 602529,611603) tubulin alpha-1A c ( 451) 949 229.7 1.2e-59 NP_005992 (OMIM: 602528) tubulin alpha-3C/D chain ( 450) 946 229.0 1.9e-59 NP_061816 (OMIM: 605742,613180) tubulin alpha-8 ch ( 449) 935 226.4 1.1e-58 NP_001061 (OMIM: 191135,615412) tubulin gamma-1 ch ( 451) 916 222.0 2.4e-57 NP_057521 (OMIM: 605785) tubulin gamma-2 chain iso ( 451) 912 221.1 4.6e-57 NP_001265481 (OMIM: 191110,616208) tubulin alpha-4 ( 433) 906 219.7 1.2e-56 NP_001257329 (OMIM: 602529,611603) tubulin alpha-1 ( 416) 868 210.8 5.2e-54 NP_001180343 (OMIM: 605742,613180) tubulin alpha-8 ( 383) 810 197.3 5.6e-50 NP_001280142 (OMIM: 156610,191130,615771) tubulin ( 242) 689 169.1 1.1e-41 NP_001307438 (OMIM: 605785) tubulin gamma-2 chain ( 460) 575 142.7 1.8e-33 XP_016860313 (OMIM: 191110,616208) PREDICTED: tubu ( 295) 534 133.1 9.5e-31 NP_057346 (OMIM: 607345) tubulin epsilon chain [Ho ( 475) 512 128.1 4.8e-29 NP_001290454 (OMIM: 615103) tubulin beta-6 chain i ( 104) 486 121.6 9.5e-28 XP_016879942 (OMIM: 605785) PREDICTED: tubulin gam ( 298) 480 120.5 5.8e-27 XP_011522916 (OMIM: 605785) PREDICTED: tubulin gam ( 298) 480 120.5 5.8e-27 XP_016880205 (OMIM: 607344) PREDICTED: tubulin del ( 375) 466 117.3 6.6e-26 >>NP_817124 (OMIM: 616768,616780) tubulin beta-8 chain [ (444 aa) initn: 2359 init1: 2359 opt: 2691 Z-score: 3381.2 bits: 634.8 E(85289): 1.3e-181 Smith-Waterman score: 2691; 93.5% identity (96.5% similar) in 431 aa overlap (1-430:1-431) 10 20 30 40 50 60 pF1KB7 MRELVLTQTGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVHHHEASGGRYV :::.:::: ::::::::::::::::::::::::::::::::::::::::...:::::::: NP_817 MREIVLTQIGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVYYNEASGGRYV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 SRAVLVDLEPGTMDSVRSGPFGQVFRPDNFISRQCGAGNNWAKGRYTEGAELTESVMDVV :::::::::::::::::::::::::::::: :::::::::::.::::::: ::::::: NP_817 PRAVLVDLEPGTMDSVRSGPFGQVFRPDNFIFGQCGAGNNWAKGHYTEGAELMESVMDVV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIWEEYPDRIINTLSILLLPKVSDTVV :::::::::::::::::::::::::::::::.::: ::::::::::.::: :::::::: NP_817 RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLLSKIREEYPDRIINTFSILPSPKVSDTVV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 EPYNATLSVHQLIENADETFCIDNEALYDICSRTLKLPTPTYGDLNHLVSATMSGVTTCL ::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::: NP_817 EPYNATLSVHQLIENADETFCIDNEALYDICSKTLKLPTPTYGDLNHLVSATMSGVTTCL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 CFPDQLNADLRKLAMNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVAELTQQMFDAKNMM :: ::::::::::.::::::::::::::::::::::::::::::::::::::::::::: NP_817 RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVAELTQQMFDAKNMM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 AARDPRHGRYLTAAAIFQGRMPMREVDEQMFNIQDKNSSYFADWFPNNVKTAVCDIPPWG :: ::::::::::::::.::::::::::::::::::::::::::.::::::::::::: : NP_817 AACDPRHGRYLTAAAIFRGRMPMREVDEQMFNIQDKNSSYFADWLPNNVKTAVCDIPPRG 310 320 330 340 350 360 370 380 390 400 410 pF1KB7 LKMSVTFTGNNTAVQEL-KRVSEQFTATFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS ::::.:: :::::.::: ::::::::: :::::::::::::::::::::::::::::::: NP_817 LKMSATFIGNNTAIQELFKRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS 370 380 390 400 410 420 420 430 pF1KB7 EYQQYQDATAEGGGV ::::::::::: NP_817 EYQQYQDATAEEEEDEEYAEEEVA 430 440 >>NP_006079 (OMIM: 602660) tubulin beta-4B chain [Homo s (445 aa) initn: 2200 init1: 2200 opt: 2533 Z-score: 3182.6 bits: 598.0 E(85289): 1.6e-170 Smith-Waterman score: 2533; 85.9% identity (94.5% similar) in 434 aa overlap (1-433:1-434) 10 20 30 40 50 60 pF1KB7 MRELVLTQTGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVHHHEASGGRYV :::.: :.:::::::::::::::::::.:: .::::::: ::::::::...::.::.:: NP_006 MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGKYV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 SRAVLVDLEPGTMDSVRSGPFGQVFRPDNFISRQCGAGNNWAKGRYTEGAELTESVMDVV ::::::::::::::::::::::.::::::. : :::::::::.:::::::..::.::: NP_006 PRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIWEEYPDRIINTLSILLLPKVSDTVV ::::::::::::::::::::::::::::::::::: :::::::.::.:.. :::::::: NP_006 RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 EPYNATLSVHQLIENADETFCIDNEALYDICSRTLKLPTPTYGDLNHLVSATMSGVTTCL ::::::::::::.::.:::.::::::::::: ::::: :::::::::::::::::::::: NP_006 EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 CFPDQLNADLRKLAMNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVAELTQQMFDAKNMM :: ::::::::::.::::::::::::::::::::::::::::::: ::::::::::::: NP_006 RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 AARDPRHGRYLTAAAIFQGRMPMREVDEQMFNIQDKNSSYFADWFPNNVKTAVCDIPPWG :: :::::::::.::.:.::: :.::::::.:.:.::::::..:.::::::::::::: : NP_006 AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG 310 320 330 340 350 360 370 380 390 400 410 pF1KB7 LKMSVTFTGNNTAVQEL-KRVSEQFTATFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS ::::.:: ::.::.::: ::.:::::: :::::::::::::::::::::::::::::::: NP_006 LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS 370 380 390 400 410 420 420 430 pF1KB7 EYQQYQDATAEGGGV ::::::::::: : NP_006 EYQQYQDATAEEEGEFEEEAEEEVA 430 440 >>NP_821133 (OMIM: 156610,191130,615771) tubulin beta ch (444 aa) initn: 2184 init1: 2184 opt: 2515 Z-score: 3160.0 bits: 593.8 E(85289): 2.8e-169 Smith-Waterman score: 2515; 85.4% identity (94.9% similar) in 431 aa overlap (1-430:1-431) 10 20 30 40 50 60 pF1KB7 MRELVLTQTGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVHHHEASGGRYV :::.: :.:::::::::::::::::::.:: .::::::: :::.::.:...::.::.:: NP_821 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLDRISVYYNEATGGKYV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 SRAVLVDLEPGTMDSVRSGPFGQVFRPDNFISRQCGAGNNWAKGRYTEGAELTESVMDVV ::.:::::::::::::::::::.::::::. : :::::::::.:::::::..::.::: NP_821 PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIWEEYPDRIINTLSILLLPKVSDTVV ::::::::::::::::::::::::::::::::::: :::::::.::.:.. :::::::: NP_821 RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 EPYNATLSVHQLIENADETFCIDNEALYDICSRTLKLPTPTYGDLNHLVSATMSGVTTCL ::::::::::::.::.:::.::::::::::: ::::: :::::::::::::::::::::: NP_821 EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 CFPDQLNADLRKLAMNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVAELTQQMFDAKNMM :: ::::::::::.::::::::::::::::::::::::::::::: :::::.::::::: NP_821 RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQVFDAKNMM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 AARDPRHGRYLTAAAIFQGRMPMREVDEQMFNIQDKNSSYFADWFPNNVKTAVCDIPPWG :: :::::::::.::.:.::: :.::::::.:.:.::::::..:.::::::::::::: : NP_821 AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG 310 320 330 340 350 360 370 380 390 400 410 pF1KB7 LKMSVTFTGNNTAVQEL-KRVSEQFTATFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS :::.::: ::.::.::: ::.:::::: :::::::::::::::::::::::::::::::: NP_821 LKMAVTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS 370 380 390 400 410 420 420 430 pF1KB7 EYQQYQDATAEGGGV ::::::::::: NP_821 EYQQYQDATAEEEEDFGEEAEEEA 430 440 >>NP_821080 (OMIM: 610031,612850) tubulin beta-2B chain (445 aa) initn: 2508 init1: 2183 opt: 2513 Z-score: 3157.5 bits: 593.4 E(85289): 3.9e-169 Smith-Waterman score: 2513; 84.8% identity (94.5% similar) in 434 aa overlap (1-433:1-434) 10 20 30 40 50 60 pF1KB7 MRELVLTQTGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVHHHEASGGRYV :::.: :.:::::::::::::::::::.:: .:.::::: ::::::::...::.:..:: NP_821 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 SRAVLVDLEPGTMDSVRSGPFGQVFRPDNFISRQCGAGNNWAKGRYTEGAELTESVMDVV ::.:::::::::::::::::::.::::::. : :::::::::.:::::::..::.::: NP_821 PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIWEEYPDRIINTLSILLLPKVSDTVV :::.::::::::::::::::::::::::::::::: :::::::.::.:.. :::::::: NP_821 RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 EPYNATLSVHQLIENADETFCIDNEALYDICSRTLKLPTPTYGDLNHLVSATMSGVTTCL ::::::::::::.::.:::.::::::::::: ::::: :::::::::::::::::::::: NP_821 EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 CFPDQLNADLRKLAMNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVAELTQQMFDAKNMM :: ::::::::::.::::::::::::::::::::::::::::::: ::::::::.:::: NP_821 RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 AARDPRHGRYLTAAAIFQGRMPMREVDEQMFNIQDKNSSYFADWFPNNVKTAVCDIPPWG :: :::::::::.::::.::: :.::::::.:.:.::::::..:.::::::::::::: : NP_821 AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG 310 320 330 340 350 360 370 380 390 400 410 pF1KB7 LKMSVTFTGNNTAVQEL-KRVSEQFTATFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS ::::.:: ::.::.::: ::.:::::: :::::::::::::::::::::::::::::::: NP_821 LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS 370 380 390 400 410 420 420 430 pF1KB7 EYQQYQDATAEGGGV ::::::::::. : NP_821 EYQQYQDATADEQGEFEEEEGEDEA 430 440 >>NP_001276058 (OMIM: 602662) tubulin beta-4A chain isof (444 aa) initn: 2510 init1: 2176 opt: 2512 Z-score: 3156.3 bits: 593.2 E(85289): 4.6e-169 Smith-Waterman score: 2512; 85.2% identity (94.5% similar) in 433 aa overlap (1-432:1-433) 10 20 30 40 50 60 pF1KB7 MRELVLTQTGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVHHHEASGGRYV :::.: :.:::::::::::::::::::.:: .::::::: ::::::::...::.:: :: NP_001 MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGNYV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 SRAVLVDLEPGTMDSVRSGPFGQVFRPDNFISRQCGAGNNWAKGRYTEGAELTESVMDVV ::::::::::::::::::::::.::::::. : :::::::::.:::::::...:.::: NP_001 PRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDAVLDVV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIWEEYPDRIINTLSILLLPKVSDTVV ::::::::::::::::::::::::::::::::::: ::.::::.::.:.. :::::::: NP_001 RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEFPDRIMNTFSVVPSPKVSDTVV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 EPYNATLSVHQLIENADETFCIDNEALYDICSRTLKLPTPTYGDLNHLVSATMSGVTTCL ::::::::::::.::.:::.::::::::::: ::::: :::::::::::::::::::::: NP_001 EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 CFPDQLNADLRKLAMNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVAELTQQMFDAKNMM :: ::::::::::.::::::::::::::::::::::::::::::: ::::::::::::: NP_001 RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 AARDPRHGRYLTAAAIFQGRMPMREVDEQMFNIQDKNSSYFADWFPNNVKTAVCDIPPWG :: :::::::::.::.:.::: :.::::::...:.::::::..:.::::::::::::: : NP_001 AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLSVQSKNSSYFVEWIPNNVKTAVCDIPPRG 310 320 330 340 350 360 370 380 390 400 410 pF1KB7 LKMSVTFTGNNTAVQEL-KRVSEQFTATFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS :::..:: ::.::.::: ::.:::::: :::::::::::::::::::::::::::::::: NP_001 LKMAATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS 370 380 390 400 410 420 420 430 pF1KB7 EYQQYQDATAEGGGV ::::::::::: : NP_001 EYQQYQDATAEEGEFEEEAEEEVA 430 440 >>NP_006078 (OMIM: 602662) tubulin beta-4A chain isoform (444 aa) initn: 2510 init1: 2176 opt: 2512 Z-score: 3156.3 bits: 593.2 E(85289): 4.6e-169 Smith-Waterman score: 2512; 85.2% identity (94.5% similar) in 433 aa overlap (1-432:1-433) 10 20 30 40 50 60 pF1KB7 MRELVLTQTGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVHHHEASGGRYV :::.: :.:::::::::::::::::::.:: .::::::: ::::::::...::.:: :: NP_006 MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGNYV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 SRAVLVDLEPGTMDSVRSGPFGQVFRPDNFISRQCGAGNNWAKGRYTEGAELTESVMDVV ::::::::::::::::::::::.::::::. : :::::::::.:::::::...:.::: NP_006 PRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDAVLDVV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIWEEYPDRIINTLSILLLPKVSDTVV ::::::::::::::::::::::::::::::::::: ::.::::.::.:.. :::::::: NP_006 RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEFPDRIMNTFSVVPSPKVSDTVV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 EPYNATLSVHQLIENADETFCIDNEALYDICSRTLKLPTPTYGDLNHLVSATMSGVTTCL ::::::::::::.::.:::.::::::::::: ::::: :::::::::::::::::::::: NP_006 EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 CFPDQLNADLRKLAMNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVAELTQQMFDAKNMM :: ::::::::::.::::::::::::::::::::::::::::::: ::::::::::::: NP_006 RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 AARDPRHGRYLTAAAIFQGRMPMREVDEQMFNIQDKNSSYFADWFPNNVKTAVCDIPPWG :: :::::::::.::.:.::: :.::::::...:.::::::..:.::::::::::::: : NP_006 AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLSVQSKNSSYFVEWIPNNVKTAVCDIPPRG 310 320 330 340 350 360 370 380 390 400 410 pF1KB7 LKMSVTFTGNNTAVQEL-KRVSEQFTATFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS :::..:: ::.::.::: ::.:::::: :::::::::::::::::::::::::::::::: NP_006 LKMAATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS 370 380 390 400 410 420 420 430 pF1KB7 EYQQYQDATAEGGGV ::::::::::: : NP_006 EYQQYQDATAEEGEFEEEAEEEVA 430 440 >>NP_001276056 (OMIM: 602662) tubulin beta-4A chain isof (489 aa) initn: 2510 init1: 2176 opt: 2512 Z-score: 3155.7 bits: 593.2 E(85289): 4.9e-169 Smith-Waterman score: 2512; 85.2% identity (94.5% similar) in 433 aa overlap (1-432:46-478) 10 20 30 pF1KB7 MRELVLTQTGQCGNQIGAKFWEVISDEHAI :::.: :.:::::::::::::::::::.: NP_001 AVSAASSTLAAAAAPRARATAAASTLSATAMREIVHLQAGQCGNQIGAKFWEVISDEHGI 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB7 DSAGTYHGDSHLQLERINVHHHEASGGRYVSRAVLVDLEPGTMDSVRSGPFGQVFRPDNF : .::::::: ::::::::...::.:: :: ::::::::::::::::::::::.:::::: NP_001 DPTGTYHGDSDLQLERINVYYNEATGGNYVPRAVLVDLEPGTMDSVRSGPFGQIFRPDNF 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB7 ISRQCGAGNNWAKGRYTEGAELTESVMDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTL . : :::::::::.:::::::...:.::::::::::::::::::::::::::::::::: NP_001 VFGQSGAGNNWAKGHYTEGAELVDAVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTL 140 150 160 170 180 190 160 170 180 190 200 210 pF1KB7 LISKIWEEYPDRIINTLSILLLPKVSDTVVEPYNATLSVHQLIENADETFCIDNEALYDI ::::: ::.::::.::.:.. ::::::::::::::::::::.::.:::.:::::::::: NP_001 LISKIREEFPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDI 200 210 220 230 240 250 220 230 240 250 260 270 pF1KB7 CSRTLKLPTPTYGDLNHLVSATMSGVTTCLCFPDQLNADLRKLAMNMVPFPRLHFFMPGF : ::::: :::::::::::::::::::::: :: ::::::::::.::::::::::::::: NP_001 CFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGF 260 270 280 290 300 310 280 290 300 310 320 330 pF1KB7 APLTSRGSQQYRALTVAELTQQMFDAKNMMAARDPRHGRYLTAAAIFQGRMPMREVDEQM :::::::::::::::: ::::::::::::::: :::::::::.::.:.::: :.:::::: NP_001 APLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQM 320 330 340 350 360 370 340 350 360 370 380 pF1KB7 FNIQDKNSSYFADWFPNNVKTAVCDIPPWGLKMSVTFTGNNTAVQEL-KRVSEQFTATFR ...:.::::::..:.::::::::::::: ::::..:: ::.::.::: ::.:::::: :: NP_001 LSVQSKNSSYFVEWIPNNVKTAVCDIPPRGLKMAATFIGNSTAIQELFKRISEQFTAMFR 380 390 400 410 420 430 390 400 410 420 430 pF1KB7 RKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEGGGV ::::::::::::::::::::::::::::::::::::::::: : NP_001 RKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEGEFEEEAEEEVA 440 450 460 470 480 >>NP_001276052 (OMIM: 602662) tubulin beta-4A chain isof (495 aa) initn: 2510 init1: 2176 opt: 2512 Z-score: 3155.6 bits: 593.2 E(85289): 5e-169 Smith-Waterman score: 2512; 85.2% identity (94.5% similar) in 433 aa overlap (1-432:52-484) 10 20 30 pF1KB7 MRELVLTQTGQCGNQIGAKFWEVISDEHAI :::.: :.:::::::::::::::::::.: NP_001 AVSAASSTLAAAAAPRARATAAASTLSATAMREIVHLQAGQCGNQIGAKFWEVISDEHGI 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB7 DSAGTYHGDSHLQLERINVHHHEASGGRYVSRAVLVDLEPGTMDSVRSGPFGQVFRPDNF : .::::::: ::::::::...::.:: :: ::::::::::::::::::::::.:::::: NP_001 DPTGTYHGDSDLQLERINVYYNEATGGNYVPRAVLVDLEPGTMDSVRSGPFGQIFRPDNF 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB7 ISRQCGAGNNWAKGRYTEGAELTESVMDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTL . : :::::::::.:::::::...:.::::::::::::::::::::::::::::::::: NP_001 VFGQSGAGNNWAKGHYTEGAELVDAVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTL 150 160 170 180 190 200 160 170 180 190 200 210 pF1KB7 LISKIWEEYPDRIINTLSILLLPKVSDTVVEPYNATLSVHQLIENADETFCIDNEALYDI ::::: ::.::::.::.:.. ::::::::::::::::::::.::.:::.:::::::::: NP_001 LISKIREEFPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDI 210 220 230 240 250 260 220 230 240 250 260 270 pF1KB7 CSRTLKLPTPTYGDLNHLVSATMSGVTTCLCFPDQLNADLRKLAMNMVPFPRLHFFMPGF : ::::: :::::::::::::::::::::: :: ::::::::::.::::::::::::::: NP_001 CFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGF 270 280 290 300 310 320 280 290 300 310 320 330 pF1KB7 APLTSRGSQQYRALTVAELTQQMFDAKNMMAARDPRHGRYLTAAAIFQGRMPMREVDEQM :::::::::::::::: ::::::::::::::: :::::::::.::.:.::: :.:::::: NP_001 APLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQM 330 340 350 360 370 380 340 350 360 370 380 pF1KB7 FNIQDKNSSYFADWFPNNVKTAVCDIPPWGLKMSVTFTGNNTAVQEL-KRVSEQFTATFR ...:.::::::..:.::::::::::::: ::::..:: ::.::.::: ::.:::::: :: NP_001 LSVQSKNSSYFVEWIPNNVKTAVCDIPPRGLKMAATFIGNSTAIQELFKRISEQFTAMFR 390 400 410 420 430 440 390 400 410 420 430 pF1KB7 RKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEGGGV ::::::::::::::::::::::::::::::::::::::::: : NP_001 RKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEGEFEEEAEEEVA 450 460 470 480 490 >>NP_001060 (OMIM: 615101,615763) tubulin beta-2A chain (445 aa) initn: 2493 init1: 2168 opt: 2498 Z-score: 3138.7 bits: 589.9 E(85289): 4.4e-168 Smith-Waterman score: 2498; 84.6% identity (94.2% similar) in 434 aa overlap (1-433:1-434) 10 20 30 40 50 60 pF1KB7 MRELVLTQTGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVHHHEASGGRYV :::.: :.:::::::::::::::::::.:: .:.::::: ::::::::...::.:..:: NP_001 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 SRAVLVDLEPGTMDSVRSGPFGQVFRPDNFISRQCGAGNNWAKGRYTEGAELTESVMDVV ::.:::::::::::::::::::.::::::. : :::::::::.:::::::..::.::: NP_001 PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIWEEYPDRIINTLSILLLPKVSDTVV :::.::::::::::::::::::::::::::::::: :::::::.::.:.. :::::::: NP_001 RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 EPYNATLSVHQLIENADETFCIDNEALYDICSRTLKLPTPTYGDLNHLVSATMSGVTTCL ::::::::::::.::.:::. :::::::::: ::::: :::::::::::::::::::::: NP_001 EPYNATLSVHQLVENTDETYSIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 CFPDQLNADLRKLAMNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVAELTQQMFDAKNMM :: ::::::::::.::::::::::::::::::::::::::::::: ::::::::.:::: NP_001 RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 AARDPRHGRYLTAAAIFQGRMPMREVDEQMFNIQDKNSSYFADWFPNNVKTAVCDIPPWG :: :::::::::.::::.::: :.::::::.:.:.::::::..:.::::::::::::: : NP_001 AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG 310 320 330 340 350 360 370 380 390 400 410 pF1KB7 LKMSVTFTGNNTAVQEL-KRVSEQFTATFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS ::::.:: ::.::.::: ::.:::::: :::::::::::::::::::::::::::::::: NP_001 LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS 370 380 390 400 410 420 420 430 pF1KB7 EYQQYQDATAEGGGV ::::::::::. : NP_001 EYQQYQDATADEQGEFEEEEGEDEA 430 440 >>NP_006077 (OMIM: 600638,602661,614039) tubulin beta-3 (450 aa) initn: 2090 init1: 2090 opt: 2423 Z-score: 3044.3 bits: 572.5 E(85289): 7.8e-163 Smith-Waterman score: 2423; 82.7% identity (92.9% similar) in 434 aa overlap (1-433:1-434) 10 20 30 40 50 60 pF1KB7 MRELVLTQTGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVHHHEASGGRYV :::.: :.:::::::::::::::::::.:: .:.: ::: ::::::.:...:::. .:: NP_006 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPSGNYVGDSDLQLERISVYYNEASSHKYV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 SRAVLVDLEPGTMDSVRSGPFGQVFRPDNFISRQCGAGNNWAKGRYTEGAELTESVMDVV ::.::::::::::::::: ::..::::::: : :::::::::.:::::::..::.::: NP_006 PRAILVDLEPGTMDSVRSGAFGHLFRPDNFIFGQSGAGNNWAKGHYTEGAELVDSVLDVV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIWEEYPDRIINTLSILLLPKVSDTVV ::: :.::::::::::::::::::::::::::::. :::::::.::.:.. :::::::: NP_006 RKECENCDCLQGFQLTHSLGGGTGSGMGTLLISKVREEYPDRIMNTFSVVPSPKVSDTVV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 EPYNATLSVHQLIENADETFCIDNEALYDICSRTLKLPTPTYGDLNHLVSATMSGVTTCL ::::::::.:::.::.:::.::::::::::: ::::: :::::::::::::::::::: : NP_006 EPYNATLSIHQLVENTDETYCIDNEALYDICFRTLKLATPTYGDLNHLVSATMSGVTTSL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 CFPDQLNADLRKLAMNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVAELTQQMFDAKNMM :: ::::::::::.:::::::::::::::::::.::::::::::: ::::::::::::: NP_006 RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGSQQYRALTVPELTQQMFDAKNMM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 AARDPRHGRYLTAAAIFQGRMPMREVDEQMFNIQDKNSSYFADWFPNNVKTAVCDIPPWG :: :::::::::.:..:.::: :.::::::. ::.::::::..:.:::::.::::::: : NP_006 AACDPRHGRYLTVATVFRGRMSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPPRG 310 320 330 340 350 360 370 380 390 400 410 pF1KB7 LKMSVTFTGNNTAVQEL-KRVSEQFTATFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS :::: :: ::.::.::: ::.:::::: :::::::::::::::::::::::::::::::: NP_006 LKMSSTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS 370 380 390 400 410 420 420 430 pF1KB7 EYQQYQDATAEGGGV ::::::::::: : NP_006 EYQQYQDATAEEEGEMYEDDEEESEAQGPK 430 440 450 434 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 06:08:46 2016 done: Fri Nov 4 06:08:47 2016 Total Scan time: 7.410 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]