Result of FASTA (omim) for
pF1KB7235
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7235, 635 aa
1>>>pF1KB7235 635 - 635 aa - 635 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.7377+/-0.000341; mu= 12.8203+/- 0.021
mean_var=112.2315+/-22.266, 0's: 0 Z-trim(118.4): 88 B-trim: 120 in 1/53
Lambda= 0.121065
statistics sampled from 31259 (31350) to 31259 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.727), E-opt: 0.2 (0.368), width: 16
Scan time: 11.200
The best scores are: opt bits E(85289)
NP_005364 (OMIM: 159530,254450,601977,604498) thro ( 635) 4494 796.0 0
XP_016856809 (OMIM: 159530,254450,601977,604498) P ( 692) 4324 766.3 0
NP_000112 (OMIM: 133100,133171) erythropoietin rec ( 508) 262 56.8 2.2e-07
XP_005261397 (OMIM: 138981,614370) PREDICTED: cyto ( 903) 200 46.1 0.00065
NP_000386 (OMIM: 138981,614370) cytokine receptor ( 897) 186 43.6 0.0035
XP_011544159 (OMIM: 147050,605383,615207) PREDICTE ( 560) 178 42.1 0.0063
NP_851565 (OMIM: 147050,605383,615207) interleukin ( 560) 178 42.1 0.0063
NP_068570 (OMIM: 147050,605383,615207) interleukin ( 538) 174 41.4 0.01
XP_016878746 (OMIM: 147050,605383,615207) PREDICTE ( 538) 174 41.4 0.01
NP_851564 (OMIM: 147050,605383,615207) interleukin ( 538) 174 41.4 0.01
>>NP_005364 (OMIM: 159530,254450,601977,604498) thrombop (635 aa)
initn: 4494 init1: 4494 opt: 4494 Z-score: 4246.7 bits: 796.0 E(85289): 0
Smith-Waterman score: 4494; 100.0% identity (100.0% similar) in 635 aa overlap (1-635:1-635)
10 20 30 40 50 60
pF1KB7 MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 GTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 TQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNST
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 GPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 CLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 CLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 CQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 CQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 IIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 IIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB7 TCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPWSSWSDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPWSSWSDP
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB7 TRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB7 QYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 QYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLG
550 560 570 580 590 600
610 620 630
pF1KB7 TMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
:::::::::::::::::::::::::::::::::::
NP_005 TMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
610 620 630
>>XP_016856809 (OMIM: 159530,254450,601977,604498) PREDI (692 aa)
initn: 4324 init1: 4324 opt: 4324 Z-score: 4085.7 bits: 766.3 E(85289): 0
Smith-Waterman score: 4324; 99.8% identity (99.8% similar) in 611 aa overlap (25-635:82-692)
10 20 30 40 50
pF1KB7 MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDE
: ::::::::::::::::::::::::::::
XP_016 RGGRVRGSPAGPLPFHINMPGRTQGQLTSCSLDVSLLASDSEPLKCFSRTFEDLTCFWDE
60 70 80 90 100 110
60 70 80 90 100 110
pF1KB7 EEAAPSGTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEAAPSGTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNV
120 130 140 150 160 170
120 130 140 150 160 170
pF1KB7 FLNQTRTQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLNQTRTQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPR
180 190 200 210 220 230
180 190 200 210 220 230
pF1KB7 DPKNSTGPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPKNSTGPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASAL
240 250 260 270 280 290
240 250 260 270 280 290
pF1KB7 TAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTL
300 310 320 330 340 350
300 310 320 330 340 350
pF1KB7 DLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHF
360 370 380 390 400 410
360 370 380 390 400 410
pF1KB7 KSRNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSRNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPS
420 430 440 450 460 470
420 430 440 450 460 470
pF1KB7 SWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPW
480 490 500 510 520 530
480 490 500 510 520 530
pF1KB7 SSWSDPTRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSWSDPTRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPD
540 550 560 570 580 590
540 550 560 570 580 590
pF1KB7 LHRVLGQYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHRVLGQYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRL
600 610 620 630 640 650
600 610 620 630
pF1KB7 QPSCLGTMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
:::::::::::::::::::::::::::::::::::::::::
XP_016 QPSCLGTMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
660 670 680 690
>>NP_000112 (OMIM: 133100,133171) erythropoietin recepto (508 aa)
initn: 269 init1: 143 opt: 262 Z-score: 253.4 bits: 56.8 E(85289): 2.2e-07
Smith-Waterman score: 265; 25.3% identity (50.9% similar) in 395 aa overlap (249-605:5-382)
220 230 240 250 260 270
pF1KB7 QDGPKQTSPSREASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTV
: : : :. : . :.:. .:. : ..
NP_000 MDHLGASLWPQVGSL--CLLLAGA--AWAPPPNL
10 20 30
280 290 300 310 320
pF1KB7 DLP---GDAVALG------LQCFTLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYP
: . :. :. : ::: :....: :.. :.: : . . . :
NP_000 PDPKFESKAALLAARGPEELLCFTERLEDLVCFWEE---AASAGVGPGNYSFSYQLEDEP
40 50 60 70 80
330 340 350 360 370 380
pF1KB7 IWENCEEEEKTNPGLQTPQFSRCHFKSRN-DSIIHILVEVTTAPGTVHSYLGSPFWIHQA
:. :. .. : . : . . . .:.. . ..::.: :. . . . :...
NP_000 -WKLCRLHQA--PTARGAVRFWCSLPTADTSSFVPLELRVTAASGAPRYH--RVIHINEV
90 100 110 120 130 140
390 400 410 420 430 440
pF1KB7 VRLPTP-NLHWREIS-SGHLELEW-QHPSSWAAQETCYQLRYT-GEGHQDWKVLEPPLGA
: : .: .: : . :::. :.: : . ... :.. . :.: . . .: :
NP_000 VLLDAPVGLVARLADESGHVVLRWLPPPETPMTSHIRYEVDVSAGNGAGSVQRVEILEGR
150 160 170 180 190 200
450 460 470 480 490 500
pF1KB7 RGGTL-ELRPRSRYRLQLRARLNGPTYQGPWSSWSDPTRVETATETAWISLVTALHLVLG
.: .:: :.:: . .:::. :.. : ::.::.:. . : .. :. .: :.:
NP_000 TECVLSNLRGRTRYTFAVRARMAEPSFGGFWSAWSEPVSLLTPSDLD--PLILTLSLIL-
210 220 230 240 250
510 520 530 540
pF1KB7 LSAVLGLLLLRWQFPAHYRRLRHALWPSLPD----------LHR---VLGQYLRDTAAL-
.:. .:: . .: : :.. .::..:. :. : : :
NP_000 --VVILVLLTVLALLSHRRALKQKIWPGIPSPESEFEGLFTTHKGNFQLWLYQNDGCLWW
260 270 280 290 300 310
550 560 570 580 590 600
pF1KB7 SP-------PKATVSDTCEEVEPSLLEILPKSSERTPL--PLCSSQAQMDYRRLQPSCLG
:: : :.. :. .. . : .... :: :. : .:: : :. :
NP_000 SPCTPFTEDPPASLEVLSERCWGTMQAVEPGTDDEGPLLEPVGSEHAQDTYLVLDKWLLP
320 330 340 350 360 370
610 620 630
pF1KB7 TMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
: :
NP_000 RNPPSEDLPGPGGSVDIVAMDEGSEASSCSSALASKPSPEGASAASFEYTILDPSSQLLR
380 390 400 410 420 430
>>XP_005261397 (OMIM: 138981,614370) PREDICTED: cytokine (903 aa)
initn: 115 init1: 74 opt: 200 Z-score: 191.2 bits: 46.1 E(85289): 0.00065
Smith-Waterman score: 210; 22.8% identity (46.8% similar) in 536 aa overlap (36-552:31-503)
10 20 30 40 50 60
pF1KB7 LFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFW-DEEEAAPSGTYQ
. :.:.. .:: : : ..: .
XP_005 MVLAQGLLSMALLALCWERSLAGAEETIPLQTLRCYNDYTSHITCRWADTQDAQRLVNVT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 LLYAYPRE--KPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWV-KNVFLNQTRT
:. .. .: .: ::.. :: .: : : .: . .: .: . .
XP_005 LIRRVNEDLLEPVSCDLSDD-MPW----SACPHPRCVPRRCVIPCQSFVVTDVDYFSFQP
70 80 90 100 110
130 140 150 160 170 180
pF1KB7 QRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYG-PRDPKNST
.: : : .. . . .: .:::: .. .: . . : :.. :
XP_005 DRPL-----GTRLTVTLTQHVQPPEPRDLQISTDQDHF----LLTWSVALGSPQSHWLSP
120 130 140 150 160
190 200 210 220 230 240
pF1KB7 GPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGS
: .... . :: .:. : .: :. ::..
XP_005 GDLEFEVVYKR-----LQDSWEDAAILLSNTSQATL----GPEH----------------
170 180 190 200
250 260 270 280 290
pF1KB7 CLISGLQPGNSYWLQLRSE-PDGISLGGSWGSWSLPVTVD-LPGD-AVALGLQCFTLDLK
:.:...: ..:.. : :.: ..:: : : ::: : .:.::
XP_005 -----LMPSSTYVARVRTRLAPGSRLSGRPSKWSPEVCWDSQPGDEAQPQNLECFFDGAA
210 220 230 240 250
300 310 320 330 340 350
pF1KB7 NVTCQWQQQDHASSQ---GFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQT---PQFSR
..:.:. . ...:. :.::. : . .::. .: :. .:
XP_005 VLSCSWEVRKEVASSVSFGLFYKPS----PDAGSAV---LLREEECSPVLREGLGSLHTR
260 270 280 290 300
360 370 380 390 400 410
pF1KB7 CHFK-SRNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEW
: . : : :.. : ..... : :..: : :.:. . .... :.:
XP_005 HHCQIPVPDPATHGQYIVSVQPRRAEKHIKSSVNIQMA---P-PSLNVTKDGDSY-SLRW
310 320 330 340 350 360
420 430 440 450 460
pF1KB7 Q-HPSSWAAQETCYQLRYTGEGHQDWK--VLEPPLGARGGTLE-LRPRSRYRLQLRARLN
. . . ....: . :: : .:.. .: :.: .:: ..:.: .
XP_005 ETMKMRYEHIDHTFEIQYRKDT-ATWKDSKTETLQNAHSMALPALEPSTRYWARVRVRTS
370 380 390 400 410 420
470 480 490 500 510 520
pF1KB7 GPTYQGPWSSWSDPTRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRH
:.: :: ::. .: :.. : :: ... :: :: ::. :: ::.
XP_005 RTGYNGIWSEWSEARSWDT--ESVLPMWVLALIVIFLTIAV--LLALRFCGIYGYR-LRR
430 440 450 460 470
530 540 550 560 570 580
pF1KB7 ALWPSLPDLHRVLGQYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQ
..:. . . .: : ::
XP_005 KWEEKIPNPSKS-HLFQNGSAELWPPGSMSAFTSGSPPHQGPWGSRFPELEGVFPVGFGD
480 490 500 510 520 530
>>NP_000386 (OMIM: 138981,614370) cytokine receptor comm (897 aa)
initn: 115 init1: 74 opt: 186 Z-score: 178.0 bits: 43.6 E(85289): 0.0035
Smith-Waterman score: 211; 22.4% identity (46.4% similar) in 532 aa overlap (36-552:31-497)
10 20 30 40 50 60
pF1KB7 LFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFW-DEEEAAPSGTYQ
. :.:.. .:: : : ..: .
NP_000 MVLAQGLLSMALLALCWERSLAGAEETIPLQTLRCYNDYTSHITCRWADTQDAQRLVNVT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 LLYAYPRE--KPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWV-KNVFLNQTRT
:. .. .: .: ::.. :: .: : : .: . .: .: . .
NP_000 LIRRVNEDLLEPVSCDLSDD-MPW----SACPHPRCVPRRCVIPCQSFVVTDVDYFSFQP
70 80 90 100 110
130 140 150 160 170 180
pF1KB7 QRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYG-PRDPKNST
.: : : .. . . .: .:::: .. .: . . : :.. :
NP_000 DRPL-----GTRLTVTLTQHVQPPEPRDLQISTDQDHF----LLTWSVALGSPQSHWLSP
120 130 140 150 160
190 200 210 220 230 240
pF1KB7 GPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGS
: .... . :: .:. : .: :. ::..
NP_000 GDLEFEVVYKR-----LQDSWEDAAILLSNTSQATL----GPEH----------------
170 180 190 200
250 260 270 280 290
pF1KB7 CLISGLQPGNSYWLQLRSE-PDGISLGGSWGSWSLPVTVD-LPGD-AVALGLQCFTLDLK
:.:...: ..:.. : :.: ..:: : : ::: : .:.::
NP_000 -----LMPSSTYVARVRTRLAPGSRLSGRPSKWSPEVCWDSQPGDEAQPQNLECFFDGAA
210 220 230 240 250
300 310 320 330 340 350
pF1KB7 NVTCQWQQQDHASSQ---GFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHF
..:.:. . ...:. :.::. .. :. .. .: : :
NP_000 VLSCSWEVRKEVASSVSFGLFYKPSPDAGEEECSPVLREGLGSLHTRHHCQIPV------
260 270 280 290 300 310
360 370 380 390 400 410
pF1KB7 KSRNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQ-HP
: : :.. : ..... : :..: : :.:. . .... :.:.
NP_000 ---PDPATHGQYIVSVQPRRAEKHIKSSVNIQMA---P-PSLNVTKDGDSY-SLRWETMK
320 330 340 350 360
420 430 440 450 460 470
pF1KB7 SSWAAQETCYQLRYTGEGHQDWK--VLEPPLGARGGTLE-LRPRSRYRLQLRARLNGPTY
. . ....: . :: : .:.. .: :.: .:: ..:.: . :
NP_000 MRYEHIDHTFEIQYRKDT-ATWKDSKTETLQNAHSMALPALEPSTRYWARVRVRTSRTGY
370 380 390 400 410 420
480 490 500 510 520 530
pF1KB7 QGPWSSWSDPTRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWP
.: :: ::. .: :.. : :: ... :: :: ::. :: ::.
NP_000 NGIWSEWSEARSWDT--ESVLPMWVLALIVIFLTIAV--LLALRFCGIYGYR-LRRKWEE
430 440 450 460 470
540 550 560 570 580 590
pF1KB7 SLPDLHRVLGQYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMD
..:. . . .: : ::
NP_000 KIPNPSKS-HLFQNGSAELWPPGSMSAFTSGSPPHQGPWGSRFPELEGVFPVGFGDSEVS
480 490 500 510 520 530
>>XP_011544159 (OMIM: 147050,605383,615207) PREDICTED: i (560 aa)
initn: 128 init1: 98 opt: 178 Z-score: 173.5 bits: 42.1 E(85289): 0.0063
Smith-Waterman score: 236; 25.1% identity (51.4% similar) in 350 aa overlap (260-579:18-347)
230 240 250 260 270 280
pF1KB7 EASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGL
: :.:. .:.. : . : : :
XP_011 MSCRCIFLMKHGERVGWPVGVSMPRGWAAPLL--LLLLQGGWGCPDL
10 20 30 40
290 300 310 320 330 340
pF1KB7 QCFTLDLKNVTCQWQQQD-HASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQ
:.: :..: : .. . : :. . .... . .:. .: ..... . :
XP_011 VCYTDYLQTVICILEMWNLHPSTLTLTWQDQYEEL-KDEAT---SCSLHRSAHNA--THA
50 60 70 80 90
350 360 370 380 390 400
pF1KB7 FSRCH---FKSRNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGH
:: :. :.:. :..: :. . :: : . .... :.: .. ::.
XP_011 TYTCHMDVFHFMADDIFS--VNITDQSGNYSQECGS-FLLAESIK-PAPPFNVTVTFSGQ
100 110 120 130 140 150
410 420 430 440 450
pF1KB7 LELEW----QHPSSWAAQ-ETCYQLRYTGEGHQDWKVLEP-----PLGARGGTL---ELR
.. : . :. . . . :.:.: ..: . : : : . .:. .: :.:
XP_011 YNISWRSDYEDPAFYMLKGKLQYELQYRNRG-DPWAV-SPRRKLISVDSRSVSLLPLEFR
160 170 180 190 200 210
460 470 480 490 500
pF1KB7 PRSRYRLQLRAR-LNGPTYQGPWSSWSDPTRVETATET---AWISLVTALHLVLGLSAVL
: :.::.:: . : .::: :: ::::. .: .: .: ::.: : :.
XP_011 KDSSYELQVRAGPMPGSSYQGTWSEWSDPVIFQTQSEELKEGWNP-----HLLLLLLLVI
220 230 240 250 260
510 520 530 540 550
pF1KB7 GLLLLRWQFPAH-YRRLRHALW--PS-----LPDLHRVLGQYLRDTAA-LSPPKATVSDT
.. :.. .: :: . .: :: .: . :.. . ..: .. . ..
XP_011 VFIPAFWSLKTHPLWRLWKKIWAVPSPERFFMPLYKGCSGDFKKWVGAPFTGSSLELGPW
270 280 290 300 310 320
560 570 580 590 600 610
pF1KB7 CEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLGTMPLSVCPPMAESGSCCTT
:: :: ::. :.:
XP_011 SPEV-PSTLEVYSCHPPRSPAKRLQLTELQEPAELVESDGVPKPSFWPTAQNSGGSAYSE
330 340 350 360 370 380
>>NP_851565 (OMIM: 147050,605383,615207) interleukin-21 (560 aa)
initn: 128 init1: 98 opt: 178 Z-score: 173.5 bits: 42.1 E(85289): 0.0063
Smith-Waterman score: 236; 25.1% identity (51.4% similar) in 350 aa overlap (260-579:18-347)
230 240 250 260 270 280
pF1KB7 EASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGL
: :.:. .:.. : . : : :
NP_851 MSCRCIFLMKHGERVGWPVGVSMPRGWAAPLL--LLLLQGGWGCPDL
10 20 30 40
290 300 310 320 330 340
pF1KB7 QCFTLDLKNVTCQWQQQD-HASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQ
:.: :..: : .. . : :. . .... . .:. .: ..... . :
NP_851 VCYTDYLQTVICILEMWNLHPSTLTLTWQDQYEEL-KDEAT---SCSLHRSAHNA--THA
50 60 70 80 90
350 360 370 380 390 400
pF1KB7 FSRCH---FKSRNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGH
:: :. :.:. :..: :. . :: : . .... :.: .. ::.
NP_851 TYTCHMDVFHFMADDIFS--VNITDQSGNYSQECGS-FLLAESIK-PAPPFNVTVTFSGQ
100 110 120 130 140 150
410 420 430 440 450
pF1KB7 LELEW----QHPSSWAAQ-ETCYQLRYTGEGHQDWKVLEP-----PLGARGGTL---ELR
.. : . :. . . . :.:.: ..: . : : : . .:. .: :.:
NP_851 YNISWRSDYEDPAFYMLKGKLQYELQYRNRG-DPWAV-SPRRKLISVDSRSVSLLPLEFR
160 170 180 190 200 210
460 470 480 490 500
pF1KB7 PRSRYRLQLRAR-LNGPTYQGPWSSWSDPTRVETATET---AWISLVTALHLVLGLSAVL
: :.::.:: . : .::: :: ::::. .: .: .: ::.: : :.
NP_851 KDSSYELQVRAGPMPGSSYQGTWSEWSDPVIFQTQSEELKEGWNP-----HLLLLLLLVI
220 230 240 250 260
510 520 530 540 550
pF1KB7 GLLLLRWQFPAH-YRRLRHALW--PS-----LPDLHRVLGQYLRDTAA-LSPPKATVSDT
.. :.. .: :: . .: :: .: . :.. . ..: .. . ..
NP_851 VFIPAFWSLKTHPLWRLWKKIWAVPSPERFFMPLYKGCSGDFKKWVGAPFTGSSLELGPW
270 280 290 300 310 320
560 570 580 590 600 610
pF1KB7 CEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLGTMPLSVCPPMAESGSCCTT
:: :: ::. :.:
NP_851 SPEV-PSTLEVYSCHPPRSPAKRLQLTELQEPAELVESDGVPKPSFWPTAQNSGGSAYSE
330 340 350 360 370 380
>>NP_068570 (OMIM: 147050,605383,615207) interleukin-21 (538 aa)
initn: 128 init1: 98 opt: 174 Z-score: 170.0 bits: 41.4 E(85289): 0.01
Smith-Waterman score: 228; 24.8% identity (51.6% similar) in 339 aa overlap (272-579:5-325)
250 260 270 280 290 300
pF1KB7 LISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDL-PGDAVALGLQCFTLDLKNVT
:. :. . : : : :.: :..:
NP_068 MPRGWAAPLLLLLLQGGWGCPDLVCYTDYLQTVI
10 20 30
310 320 330 340 350
pF1KB7 CQWQQQD-HASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCH---FKS
: .. . : :. . .... . .:. .: ..... . .. :: :.
NP_068 CILEMWNLHPSTLTLTWQDQYEEL-KDEAT---SCSLHRSAHNATHATY--TCHMDVFHF
40 50 60 70 80
360 370 380 390 400 410
pF1KB7 RNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEW----QH
:.:. :..: :. . :: : . .... :.: .. ::. .. : .
NP_068 MADDIFS--VNITDQSGNYSQECGS-FLLAESIK-PAPPFNVTVTFSGQYNISWRSDYED
90 100 110 120 130 140
420 430 440 450 460
pF1KB7 PSSWAAQ-ETCYQLRYTGEGHQDWKVLEP-----PLGARGGTL---ELRPRSRYRLQLRA
:. . . . :.:.: ..: . : : : . .:. .: :.: : :.::.::
NP_068 PAFYMLKGKLQYELQYRNRG-DPWAV-SPRRKLISVDSRSVSLLPLEFRKDSSYELQVRA
150 160 170 180 190 200
470 480 490 500 510
pF1KB7 R-LNGPTYQGPWSSWSDPTRVETATET---AWISLVTALHLVLGLSAVLGLLLLRWQFPA
. : .::: :: ::::. .: .: .: ::.: : :. .. :.. .
NP_068 GPMPGSSYQGTWSEWSDPVIFQTQSEELKEGWNP-----HLLLLLLLVIVFIPAFWSLKT
210 220 230 240 250
520 530 540 550 560 570
pF1KB7 H-YRRLRHALW--PS-----LPDLHRVLGQYLRDTAA-LSPPKATVSDTCEEVEPSLLEI
: :: . .: :: .: . :.. . ..: .. . .. :: :: ::.
NP_068 HPLWRLWKKIWAVPSPERFFMPLYKGCSGDFKKWVGAPFTGSSLELGPWSPEV-PSTLEV
260 270 280 290 300 310
580 590 600 610 620 630
pF1KB7 LPKSSERTPLPLCSSQAQMDYRRLQPSCLGTMPLSVCPPMAESGSCCTTHIANHSYLPLS
:.:
NP_068 YSCHPPRSPAKRLQLTELQEPAELVESDGVPKPSFWPTAQNSGGSAYSEERDRPYGLVSI
320 330 340 350 360 370
>>XP_016878746 (OMIM: 147050,605383,615207) PREDICTED: i (538 aa)
initn: 128 init1: 98 opt: 174 Z-score: 170.0 bits: 41.4 E(85289): 0.01
Smith-Waterman score: 228; 24.8% identity (51.6% similar) in 339 aa overlap (272-579:5-325)
250 260 270 280 290 300
pF1KB7 LISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDL-PGDAVALGLQCFTLDLKNVT
:. :. . : : : :.: :..:
XP_016 MPRGWAAPLLLLLLQGGWGCPDLVCYTDYLQTVI
10 20 30
310 320 330 340 350
pF1KB7 CQWQQQD-HASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCH---FKS
: .. . : :. . .... . .:. .: ..... . .. :: :.
XP_016 CILEMWNLHPSTLTLTWQDQYEEL-KDEAT---SCSLHRSAHNATHATY--TCHMDVFHF
40 50 60 70 80
360 370 380 390 400 410
pF1KB7 RNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEW----QH
:.:. :..: :. . :: : . .... :.: .. ::. .. : .
XP_016 MADDIFS--VNITDQSGNYSQECGS-FLLAESIK-PAPPFNVTVTFSGQYNISWRSDYED
90 100 110 120 130 140
420 430 440 450 460
pF1KB7 PSSWAAQ-ETCYQLRYTGEGHQDWKVLEP-----PLGARGGTL---ELRPRSRYRLQLRA
:. . . . :.:.: ..: . : : : . .:. .: :.: : :.::.::
XP_016 PAFYMLKGKLQYELQYRNRG-DPWAV-SPRRKLISVDSRSVSLLPLEFRKDSSYELQVRA
150 160 170 180 190 200
470 480 490 500 510
pF1KB7 R-LNGPTYQGPWSSWSDPTRVETATET---AWISLVTALHLVLGLSAVLGLLLLRWQFPA
. : .::: :: ::::. .: .: .: ::.: : :. .. :.. .
XP_016 GPMPGSSYQGTWSEWSDPVIFQTQSEELKEGWNP-----HLLLLLLLVIVFIPAFWSLKT
210 220 230 240 250
520 530 540 550 560 570
pF1KB7 H-YRRLRHALW--PS-----LPDLHRVLGQYLRDTAA-LSPPKATVSDTCEEVEPSLLEI
: :: . .: :: .: . :.. . ..: .. . .. :: :: ::.
XP_016 HPLWRLWKKIWAVPSPERFFMPLYKGCSGDFKKWVGAPFTGSSLELGPWSPEV-PSTLEV
260 270 280 290 300 310
580 590 600 610 620 630
pF1KB7 LPKSSERTPLPLCSSQAQMDYRRLQPSCLGTMPLSVCPPMAESGSCCTTHIANHSYLPLS
:.:
XP_016 YSCHPPRSPAKRLQLTELQEPAELVESDGVPKPSFWPTAQNSGGSAYSEERDRPYGLVSI
320 330 340 350 360 370
>>NP_851564 (OMIM: 147050,605383,615207) interleukin-21 (538 aa)
initn: 128 init1: 98 opt: 174 Z-score: 170.0 bits: 41.4 E(85289): 0.01
Smith-Waterman score: 228; 24.8% identity (51.6% similar) in 339 aa overlap (272-579:5-325)
250 260 270 280 290 300
pF1KB7 LISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDL-PGDAVALGLQCFTLDLKNVT
:. :. . : : : :.: :..:
NP_851 MPRGWAAPLLLLLLQGGWGCPDLVCYTDYLQTVI
10 20 30
310 320 330 340 350
pF1KB7 CQWQQQD-HASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCH---FKS
: .. . : :. . .... . .:. .: ..... . .. :: :.
NP_851 CILEMWNLHPSTLTLTWQDQYEEL-KDEAT---SCSLHRSAHNATHATY--TCHMDVFHF
40 50 60 70 80
360 370 380 390 400 410
pF1KB7 RNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEW----QH
:.:. :..: :. . :: : . .... :.: .. ::. .. : .
NP_851 MADDIFS--VNITDQSGNYSQECGS-FLLAESIK-PAPPFNVTVTFSGQYNISWRSDYED
90 100 110 120 130 140
420 430 440 450 460
pF1KB7 PSSWAAQ-ETCYQLRYTGEGHQDWKVLEP-----PLGARGGTL---ELRPRSRYRLQLRA
:. . . . :.:.: ..: . : : : . .:. .: :.: : :.::.::
NP_851 PAFYMLKGKLQYELQYRNRG-DPWAV-SPRRKLISVDSRSVSLLPLEFRKDSSYELQVRA
150 160 170 180 190 200
470 480 490 500 510
pF1KB7 R-LNGPTYQGPWSSWSDPTRVETATET---AWISLVTALHLVLGLSAVLGLLLLRWQFPA
. : .::: :: ::::. .: .: .: ::.: : :. .. :.. .
NP_851 GPMPGSSYQGTWSEWSDPVIFQTQSEELKEGWNP-----HLLLLLLLVIVFIPAFWSLKT
210 220 230 240 250
520 530 540 550 560 570
pF1KB7 H-YRRLRHALW--PS-----LPDLHRVLGQYLRDTAA-LSPPKATVSDTCEEVEPSLLEI
: :: . .: :: .: . :.. . ..: .. . .. :: :: ::.
NP_851 HPLWRLWKKIWAVPSPERFFMPLYKGCSGDFKKWVGAPFTGSSLELGPWSPEV-PSTLEV
260 270 280 290 300 310
580 590 600 610 620 630
pF1KB7 LPKSSERTPLPLCSSQAQMDYRRLQPSCLGTMPLSVCPPMAESGSCCTTHIANHSYLPLS
:.:
NP_851 YSCHPPRSPAKRLQLTELQEPAELVESDGVPKPSFWPTAQNSGGSAYSEERDRPYGLVSI
320 330 340 350 360 370
635 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 06:10:41 2016 done: Fri Nov 4 06:10:42 2016
Total Scan time: 11.200 Total Display time: 0.090
Function used was FASTA [36.3.4 Apr, 2011]