FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7237, 481 aa 1>>>pF1KB7237 481 - 481 aa - 481 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.5763+/-0.000395; mu= 22.0022+/- 0.024 mean_var=67.6131+/-13.580, 0's: 0 Z-trim(111.4): 53 B-trim: 0 in 0/55 Lambda= 0.155976 statistics sampled from 19888 (19936) to 19888 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.601), E-opt: 0.2 (0.234), width: 16 Scan time: 8.970 The best scores are: opt bits E(85289) NP_945347 (OMIM: 145750,609252) lipase member I is ( 481) 3295 750.9 1.8e-216 NP_001289927 (OMIM: 145750,609252) lipase member I ( 460) 3064 698.9 7.7e-201 NP_001289929 (OMIM: 145750,609252) lipase member I ( 454) 2985 681.1 1.7e-195 XP_006724028 (OMIM: 145750,609252) PREDICTED: lipa ( 404) 2501 572.2 9.6e-163 NP_001289930 (OMIM: 145750,609252) lipase member I ( 375) 2253 516.3 5.7e-146 NP_001289928 (OMIM: 145750,609252) lipase member I ( 430) 1479 342.2 1.7e-93 NP_640341 (OMIM: 604379,607365) lipase member H pr ( 451) 1399 324.2 4.6e-88 XP_011510832 (OMIM: 604379,607365) PREDICTED: lipa ( 408) 1357 314.7 3e-85 XP_011510833 (OMIM: 604379,607365) PREDICTED: lipa ( 408) 1357 314.7 3e-85 NP_056984 (OMIM: 607460) phospholipase A1 member A ( 456) 867 204.5 5.1e-52 NP_001280154 (OMIM: 607460) phospholipase A1 membe ( 440) 861 203.1 1.3e-51 XP_006713592 (OMIM: 604379,607365) PREDICTED: lipa ( 421) 720 171.4 4.4e-42 NP_001193889 (OMIM: 607460) phospholipase A1 membe ( 440) 658 157.5 7.1e-38 NP_001193890 (OMIM: 607460) phospholipase A1 membe ( 283) 565 136.4 1e-31 XP_016862061 (OMIM: 607460) PREDICTED: phospholipa ( 283) 565 136.4 1e-31 NP_005387 (OMIM: 604423) pancreatic lipase-related ( 470) 558 135.0 4.4e-31 XP_016861341 (OMIM: 604379,607365) PREDICTED: lipa ( 417) 555 134.3 6.5e-31 NP_000927 (OMIM: 246600,614338) pancreatic triacyl ( 465) 542 131.4 5.4e-30 NP_006024 (OMIM: 603684) endothelial lipase isofor ( 500) 512 124.7 6.1e-28 XP_005258447 (OMIM: 603684) PREDICTED: endothelial ( 536) 512 124.7 6.4e-28 XP_011524569 (OMIM: 603684) PREDICTED: endothelial ( 420) 498 121.4 4.8e-27 NP_006220 (OMIM: 604422) inactive pancreatic lipas ( 467) 482 117.9 6.2e-26 NP_001290064 (OMIM: 604422) inactive pancreatic li ( 467) 482 117.9 6.2e-26 XP_011538170 (OMIM: 604422) PREDICTED: inactive pa ( 467) 482 117.9 6.2e-26 XP_016871828 (OMIM: 604423) PREDICTED: pancreatic ( 249) 470 114.9 2.6e-25 NP_000228 (OMIM: 144250,238600,609708) lipoprotein ( 475) 453 111.4 5.8e-24 XP_006720565 (OMIM: 125853,151670,612797,614025) P ( 452) 421 104.1 8.2e-22 NP_000227 (OMIM: 125853,151670,612797,614025) hepa ( 499) 421 104.2 8.8e-22 XP_005254429 (OMIM: 125853,151670,612797,614025) P ( 499) 421 104.2 8.8e-22 XP_005254431 (OMIM: 125853,151670,612797,614025) P ( 511) 421 104.2 9e-22 XP_016877665 (OMIM: 125853,151670,612797,614025) P ( 398) 396 98.5 3.7e-20 XP_011538171 (OMIM: 604422) PREDICTED: inactive pa ( 318) 341 86.0 1.7e-16 XP_016881584 (OMIM: 603684) PREDICTED: endothelial ( 303) 324 82.2 2.3e-15 NP_001294935 (OMIM: 603684) endothelial lipase iso ( 426) 263 68.6 4e-11 XP_011524567 (OMIM: 603684) PREDICTED: endothelial ( 462) 263 68.6 4.2e-11 >>NP_945347 (OMIM: 145750,609252) lipase member I isofor (481 aa) initn: 3295 init1: 3295 opt: 3295 Z-score: 4007.4 bits: 750.9 E(85289): 1.8e-216 Smith-Waterman score: 3295; 99.8% identity (99.8% similar) in 481 aa overlap (1-481:1-481) 10 20 30 40 50 60 pF1KB7 MLLKCLHNNLCQKYSAHAFQFSPRNVLWLLVVCLRSDNKRPCLEFSQLSVKDSFRDLFIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_945 MLLKCLHNNLCQKYSAHAFQFSPRNVLWLLVVCLRSDNKRPCLEFSQLSVKDSFRDLFIP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 RIETILMMYTRNNLNCAEPLFEQNNSLNVNFNTQKKTVWLIHGYRPVGSIPLWLQNFVRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_945 RIETILMMYTRNNLNCAEPLFEQNNSLNVNFNTQKKTVWLIHGYRPVGSIPLWLQNFVRI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 LLNEEDMNVIVVDWSRGATTFIYNRAVKNTRKVAVSLSVHIKNLLKHGASLDNFHFIGVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_945 LLNEEDMNVIVVDWSRGATTFIYNRAVKNTRKVAVSLSVHIKNLLKHGASLDNFHFIGVS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 LGAHISGFVGKIFHGQLGRITGLDPAGPRFSRKPPYSRLDYTDAKFVDVIHSDSNGLGIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_945 LGAHISGFVGKIFHGQLGRITGLDPAGPRFSRKPPYSRLDYTDAKFVDVIHSDSNGLGIQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 EPLGHIDFYPNGGNKQPGCPKSIFSGIQFIKCNHQRAVHLFMASLETNCNFISFPCRSYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_945 EPLGHIDFYPNGGNKQPGCPKSIFSGIQFIKCNHQRAVHLFMASLETNCNFISFPCRSYK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 DYKTSLCVDCDCFKEKSCPRLGYQAKLFKGVLKERMEGRPLRTTVFLDTSGTYPFCTYYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_945 DYKTSLCVDCDCFKEKSCPRLGYQAKLFKGVLKERMEGRPLRTTVFLDTSGTYPFCTYYF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 VLSIIVPDKTMMDGSFSFKLLNQLGMIEEPRLYEKNKPFYKLQEVKILAQFYNDFVNISS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_945 VLSIIVPDKTMMDGSFSFKLLNQLGMIEEPRLYEKNKPFYKLQEVKILAQFYNDFVNISS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB7 IGLTYFQSSNLQCSTCTYKIQRLMLKSLTYPERPPLCRYNIVLKDREEVFLNPNTCTPKN ::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::: NP_945 IGLTYFQSSNLQCSTCTYKIQSLMLKSLTYPERPPLCRYNIVLKDREEVFLNPNTCTPKN 430 440 450 460 470 480 pF1KB7 T : NP_945 T >>NP_001289927 (OMIM: 145750,609252) lipase member I iso (460 aa) initn: 3052 init1: 3052 opt: 3064 Z-score: 3726.7 bits: 698.9 E(85289): 7.7e-201 Smith-Waterman score: 3064; 97.8% identity (98.9% similar) in 459 aa overlap (24-481:2-460) 10 20 30 40 50 pF1KB7 MLLKCLHNNLCQKYSAHAFQFSPRNVLWLLVVC-LRSDNKRPCLEFSQLSVKDSFRDLFI : ..: ..: .::::::::::::::::::::::::: NP_001 MRVYIFLCLMCWVRSDNKRPCLEFSQLSVKDSFRDLFI 10 20 30 60 70 80 90 100 110 pF1KB7 PRIETILMMYTRNNLNCAEPLFEQNNSLNVNFNTQKKTVWLIHGYRPVGSIPLWLQNFVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PRIETILMMYTRNNLNCAEPLFEQNNSLNVNFNTQKKTVWLIHGYRPVGSIPLWLQNFVR 40 50 60 70 80 90 120 130 140 150 160 170 pF1KB7 ILLNEEDMNVIVVDWSRGATTFIYNRAVKNTRKVAVSLSVHIKNLLKHGASLDNFHFIGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILLNEEDMNVIVVDWSRGATTFIYNRAVKNTRKVAVSLSVHIKNLLKHGASLDNFHFIGV 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB7 SLGAHISGFVGKIFHGQLGRITGLDPAGPRFSRKPPYSRLDYTDAKFVDVIHSDSNGLGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLGAHISGFVGKIFHGQLGRITGLDPAGPRFSRKPPYSRLDYTDAKFVDVIHSDSNGLGI 160 170 180 190 200 210 240 250 260 270 280 290 pF1KB7 QEPLGHIDFYPNGGNKQPGCPKSIFSGIQFIKCNHQRAVHLFMASLETNCNFISFPCRSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QEPLGHIDFYPNGGNKQPGCPKSIFSGIQFIKCNHQRAVHLFMASLETNCNFISFPCRSY 220 230 240 250 260 270 300 310 320 330 340 350 pF1KB7 KDYKTSLCVDCDCFKEKSCPRLGYQAKLFKGVLKERMEGRPLRTTVFLDTSGTYPFCTYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KDYKTSLCVDCDCFKEKSCPRLGYQAKLFKGVLKERMEGRPLRTTVFLDTSGTYPFCTYY 280 290 300 310 320 330 360 370 380 390 400 410 pF1KB7 FVLSIIVPDKTMMDGSFSFKLLNQLGMIEEPRLYEKNKPFYKLQEVKILAQFYNDFVNIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FVLSIIVPDKTMMDGSFSFKLLNQLGMIEEPRLYEKNKPFYKLQEVKILAQFYNDFVNIS 340 350 360 370 380 390 420 430 440 450 460 470 pF1KB7 SIGLTYFQSSNLQCSTCTYKIQRLMLKSLTYPERPPLCRYNIVLKDREEVFLNPNTCTPK :::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::: NP_001 SIGLTYFQSSNLQCSTCTYKIQSLMLKSLTYPERPPLCRYNIVLKDREEVFLNPNTCTPK 400 410 420 430 440 450 480 pF1KB7 NT :: NP_001 NT 460 >>NP_001289929 (OMIM: 145750,609252) lipase member I iso (454 aa) initn: 2180 init1: 2180 opt: 2985 Z-score: 3630.7 bits: 681.1 E(85289): 1.7e-195 Smith-Waterman score: 2985; 96.3% identity (97.6% similar) in 459 aa overlap (24-481:2-454) 10 20 30 40 50 pF1KB7 MLLKCLHNNLCQKYSAHAFQFSPRNVLWLLVVC-LRSDNKRPCLEFSQLSVKDSFRDLFI : ..: ..: .::::::::::::::::::::::::: NP_001 MRVYIFLCLMCWVRSDNKRPCLEFSQLSVKDSFRDLFI 10 20 30 60 70 80 90 100 110 pF1KB7 PRIETILMMYTRNNLNCAEPLFEQNNSLNVNFNTQKKTVWLIHGYRPVGSIPLWLQNFVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PRIETILMMYTRNNLNCAEPLFEQNNSLNVNFNTQKKTVWLIHGYRPVGSIPLWLQNFVR 40 50 60 70 80 90 120 130 140 150 160 170 pF1KB7 ILLNEEDMNVIVVDWSRGATTFIYNRAVKNTRKVAVSLSVHIKNLLKHGASLDNFHFIGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILLNEEDMNVIVVDWSRGATTFIYNRAVKNTRKVAVSLSVHIKNLLKHGASLDNFHFIGV 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB7 SLGAHISGFVGKIFHGQLGRITGLDPAGPRFSRKPPYSRLDYTDAKFVDVIHSDSNGLGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLGAHISGFVGKIFHGQLGRITGLDPAGPRFSRKPPYSRLDYTDAKFVDVIHSDSNGLGI 160 170 180 190 200 210 240 250 260 270 280 290 pF1KB7 QEPLGHIDFYPNGGNKQPGCPKSIFSGIQFIKCNHQRAVHLFMASLETNCNFISFPCRSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QEPLGHIDFYPNGGNKQPGCPKSIFSGIQFIKCNHQRAVHLFMASLETNCNFISFPCRSY 220 230 240 250 260 270 300 310 320 330 340 350 pF1KB7 KDYKTSLCVDCDCFKEKSCPRLGYQAKLFKGVLKERMEGRPLRTTVFLDTSGTYPFCTYY :::::::::::::::::::::::::::::::::::::::::::::::::::. :: NP_001 KDYKTSLCVDCDCFKEKSCPRLGYQAKLFKGVLKERMEGRPLRTTVFLDTSA------YY 280 290 300 310 320 330 360 370 380 390 400 410 pF1KB7 FVLSIIVPDKTMMDGSFSFKLLNQLGMIEEPRLYEKNKPFYKLQEVKILAQFYNDFVNIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FVLSIIVPDKTMMDGSFSFKLLNQLGMIEEPRLYEKNKPFYKLQEVKILAQFYNDFVNIS 340 350 360 370 380 390 420 430 440 450 460 470 pF1KB7 SIGLTYFQSSNLQCSTCTYKIQRLMLKSLTYPERPPLCRYNIVLKDREEVFLNPNTCTPK :::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::: NP_001 SIGLTYFQSSNLQCSTCTYKIQSLMLKSLTYPERPPLCRYNIVLKDREEVFLNPNTCTPK 400 410 420 430 440 450 480 pF1KB7 NT :: NP_001 NT >>XP_006724028 (OMIM: 145750,609252) PREDICTED: lipase m (404 aa) initn: 2473 init1: 2473 opt: 2501 Z-score: 3042.7 bits: 572.2 E(85289): 9.6e-163 Smith-Waterman score: 2501; 93.9% identity (96.7% similar) in 396 aa overlap (3-395:8-403) 10 20 30 40 50 pF1KB7 MLLKCLHNNLCQKYSA-HAF-QFSPRNVLWLLVVC-LRSDNKRPCLEFSQLSVKD :. :.: : . :: :: .:. : ..: ..: .:::::::::::::::::: XP_006 MILPKRNLNELRNFLFGELSAVFAFLRFQMRVYIFLCLMCWVRSDNKRPCLEFSQLSVKD 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 SFRDLFIPRIETILMMYTRNNLNCAEPLFEQNNSLNVNFNTQKKTVWLIHGYRPVGSIPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SFRDLFIPRIETILMMYTRNNLNCAEPLFEQNNSLNVNFNTQKKTVWLIHGYRPVGSIPL 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 WLQNFVRILLNEEDMNVIVVDWSRGATTFIYNRAVKNTRKVAVSLSVHIKNLLKHGASLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 WLQNFVRILLNEEDMNVIVVDWSRGATTFIYNRAVKNTRKVAVSLSVHIKNLLKHGASLD 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 NFHFIGVSLGAHISGFVGKIFHGQLGRITGLDPAGPRFSRKPPYSRLDYTDAKFVDVIHS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NFHFIGVSLGAHISGFVGKIFHGQLGRITGLDPAGPRFSRKPPYSRLDYTDAKFVDVIHS 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB7 DSNGLGIQEPLGHIDFYPNGGNKQPGCPKSIFSGIQFIKCNHQRAVHLFMASLETNCNFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DSNGLGIQEPLGHIDFYPNGGNKQPGCPKSIFSGIQFIKCNHQRAVHLFMASLETNCNFI 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB7 SFPCRSYKDYKTSLCVDCDCFKEKSCPRLGYQAKLFKGVLKERMEGRPLRTTVFLDTSGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SFPCRSYKDYKTSLCVDCDCFKEKSCPRLGYQAKLFKGVLKERMEGRPLRTTVFLDTSGT 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB7 YPFCTYYFVLSIIVPDKTMMDGSFSFKLLNQLGMIEEPRLYEKNKPFYKLQEVKILAQFY ::::::::::::::::::::::::::::::::::::::::::. XP_006 YPFCTYYFVLSIIVPDKTMMDGSFSFKLLNQLGMIEEPRLYEER 370 380 390 400 420 430 440 450 460 470 pF1KB7 NDFVNISSIGLTYFQSSNLQCSTCTYKIQRLMLKSLTYPERPPLCRYNIVLKDREEVFLN >>NP_001289930 (OMIM: 145750,609252) lipase member I iso (375 aa) initn: 2237 init1: 2237 opt: 2253 Z-score: 2741.6 bits: 516.3 E(85289): 5.7e-146 Smith-Waterman score: 2253; 94.8% identity (98.0% similar) in 348 aa overlap (24-370:2-348) 10 20 30 40 50 pF1KB7 MLLKCLHNNLCQKYSAHAFQFSPRNVLWLLVVC-LRSDNKRPCLEFSQLSVKDSFRDLFI : ..: ..: .::::::::::::::::::::::::: NP_001 MRVYIFLCLMCWVRSDNKRPCLEFSQLSVKDSFRDLFI 10 20 30 60 70 80 90 100 110 pF1KB7 PRIETILMMYTRNNLNCAEPLFEQNNSLNVNFNTQKKTVWLIHGYRPVGSIPLWLQNFVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PRIETILMMYTRNNLNCAEPLFEQNNSLNVNFNTQKKTVWLIHGYRPVGSIPLWLQNFVR 40 50 60 70 80 90 120 130 140 150 160 170 pF1KB7 ILLNEEDMNVIVVDWSRGATTFIYNRAVKNTRKVAVSLSVHIKNLLKHGASLDNFHFIGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILLNEEDMNVIVVDWSRGATTFIYNRAVKNTRKVAVSLSVHIKNLLKHGASLDNFHFIGV 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB7 SLGAHISGFVGKIFHGQLGRITGLDPAGPRFSRKPPYSRLDYTDAKFVDVIHSDSNGLGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLGAHISGFVGKIFHGQLGRITGLDPAGPRFSRKPPYSRLDYTDAKFVDVIHSDSNGLGI 160 170 180 190 200 210 240 250 260 270 280 290 pF1KB7 QEPLGHIDFYPNGGNKQPGCPKSIFSGIQFIKCNHQRAVHLFMASLETNCNFISFPCRSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QEPLGHIDFYPNGGNKQPGCPKSIFSGIQFIKCNHQRAVHLFMASLETNCNFISFPCRSY 220 230 240 250 260 270 300 310 320 330 340 350 pF1KB7 KDYKTSLCVDCDCFKEKSCPRLGYQAKLFKGVLKERMEGRPLRTTVFLDTSGTYPFCTYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::... NP_001 KDYKTSLCVDCDCFKEKSCPRLGYQAKLFKGVLKERMEGRPLRTTVFLDTSGTYPFCNHH 280 290 300 310 320 330 360 370 380 390 400 410 pF1KB7 FVLSIIVPDKTMMDGSFSFKLLNQLGMIEEPRLYEKNKPFYKLQEVKILAQFYNDFVNIS :. .::. :: NP_001 FA-GIILYLKTERKCFLIQTHVHQRTHKMPSSIKCTCL 340 350 360 370 >>NP_001289928 (OMIM: 145750,609252) lipase member I iso (430 aa) initn: 1479 init1: 1479 opt: 1479 Z-score: 1799.5 bits: 342.2 E(85289): 1.7e-93 Smith-Waterman score: 2770; 91.3% identity (92.4% similar) in 459 aa overlap (24-481:2-430) 10 20 30 40 50 pF1KB7 MLLKCLHNNLCQKYSAHAFQFSPRNVLWLLVVC-LRSDNKRPCLEFSQLSVKDSFRDLFI : ..: ..: .::::::::::::::::::::::::: NP_001 MRVYIFLCLMCWVRSDNKRPCLEFSQLSVKDSFRDLFI 10 20 30 60 70 80 90 100 110 pF1KB7 PRIETILMMYTRNNLNCAEPLFEQNNSLNVNFNTQKKTVWLIHGYRPVGSIPLWLQNFVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PRIETILMMYTRNNLNCAEPLFEQNNSLNVNFNTQKKTVWLIHGYRPVGSIPLWLQNFVR 40 50 60 70 80 90 120 130 140 150 160 170 pF1KB7 ILLNEEDMNVIVVDWSRGATTFIYNRAVKNTRKVAVSLSVHIKNLLKHGASLDNFHFIGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILLNEEDMNVIVVDWSRGATTFIYNRAVKNTRKVAVSLSVHIKNLLKHGASLDNFHFIGV 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB7 SLGAHISGFVGKIFHGQLGRITGLDPAGPRFSRKPPYSRLDYTDAKFVDVIHSDSNGLGI ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLGAHISGFVGKIFHGQLGRITGLDPAGPRFSRKPPYSRLDYTDAKFVDVIHSDSNG--- 160 170 180 190 200 210 240 250 260 270 280 290 pF1KB7 QEPLGHIDFYPNGGNKQPGCPKSIFSGIQFIKCNHQRAVHLFMASLETNCNFISFPCRSY ::::::::::::::::::::::::::::::::: NP_001 ---------------------------IQFIKCNHQRAVHLFMASLETNCNFISFPCRSY 220 230 240 300 310 320 330 340 350 pF1KB7 KDYKTSLCVDCDCFKEKSCPRLGYQAKLFKGVLKERMEGRPLRTTVFLDTSGTYPFCTYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KDYKTSLCVDCDCFKEKSCPRLGYQAKLFKGVLKERMEGRPLRTTVFLDTSGTYPFCTYY 250 260 270 280 290 300 360 370 380 390 400 410 pF1KB7 FVLSIIVPDKTMMDGSFSFKLLNQLGMIEEPRLYEKNKPFYKLQEVKILAQFYNDFVNIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FVLSIIVPDKTMMDGSFSFKLLNQLGMIEEPRLYEKNKPFYKLQEVKILAQFYNDFVNIS 310 320 330 340 350 360 420 430 440 450 460 470 pF1KB7 SIGLTYFQSSNLQCSTCTYKIQRLMLKSLTYPERPPLCRYNIVLKDREEVFLNPNTCTPK :::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::: NP_001 SIGLTYFQSSNLQCSTCTYKIQSLMLKSLTYPERPPLCRYNIVLKDREEVFLNPNTCTPK 370 380 390 400 410 420 480 pF1KB7 NT :: NP_001 NT 430 >>NP_640341 (OMIM: 604379,607365) lipase member H precur (451 aa) initn: 1337 init1: 1030 opt: 1399 Z-score: 1701.9 bits: 324.2 E(85289): 4.6e-88 Smith-Waterman score: 1399; 45.7% identity (77.6% similar) in 455 aa overlap (24-476:3-446) 10 20 30 40 50 pF1KB7 MLLKCLHNNLCQKYSAHAFQFSPRNVLWLLVVCL-RSDNKRPCLEFSQLSVKDSFRDLFI : :.. ..:: ::: .. : :..:: ... . NP_640 MLRFYLFISLLCLSRSDAEETCPSFTRLSFHSA---VVG 10 20 30 60 70 80 90 100 110 pF1KB7 PRIETILMMYTRNNLNCAEPLFEQNNSLNVNFNTQKKTVWLIHGYRPVGSIPLWLQNFVR ... ::.:::.::.::. . :.: :.:. :::....::.::.:: :.:....:. NP_640 TGLNVRLMLYTRKNLTCAQTI---NSSAFGNLNVTKKTTFIVHGFRPTGSPPVWMDDLVK 40 50 60 70 80 90 120 130 140 150 160 170 pF1KB7 ILLNEEDMNVIVVDWSRGATTFIYNRAVKNTRKVAVSLSVHIKNLLKHGASLDNFHFIGV ::. :::::.::::.:::::.::..: ..:::::. :. : ..: .:::::....::: NP_640 GLLSVEDMNVVVVDWNRGATTLIYTHASSKTRKVAMVLKEFIDQMLAEGASLDDIYMIGV 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB7 SLGAHISGFVGKIFHGQLGRITGLDPAGPRFSRKPPYSRLDYTDAKFVDVIHSDSNGLGI :::::::::::... : :::::::::::: :. :: .::: .::.::::::::...:: NP_640 SLGAHISGFVGEMYDGWLGRITGLDPAGPLFNGKPHQDRLDPSDAQFVDVIHSDTDALGY 160 170 180 190 200 210 240 250 260 270 280 290 pF1KB7 QEPLGHIDFYPNGGNKQPGCPKSIFSGIQFIKCNHQRAVHLFMASLETNCNFISFPCRSY .::::.:::::::: ::::::.:..:.:..::.:::.:.:...::. .:.. ..:: :: NP_640 KEPLGNIDFYPNGGLDQPGCPKTILGGFQYFKCDHQRSVYLYLSSLRESCTITAYPCDSY 220 230 240 250 260 270 300 310 320 330 340 350 pF1KB7 KDYKTSLCVDCDCFKEKSCPRLGYQAKLFKGVLKERMEGR-PLRTTVFLDTSGTYPFCTY .::... ::.: ...::: ::: : .: ....:. : : .:.::. ::: : NP_640 QDYRNGKCVSCGTSQKESCPLLGYYADNWK----DHLRGKDPPMTKAFFDTAEESPFCMY 280 290 300 310 320 360 370 380 390 400 410 pF1KB7 YFVLSIIVPDKTMMDGSFSFKLLNQLGMIEEPRLYEKNKPFYKLQEVKILAQFYNDFVNI .. ..::. .:.. :....:: .. : : .. .. : : ..:..::.: .:. .. NP_640 HYFVDIITWNKNVRRGDITIKLRDKAGNTTESKINHEPTTFQKYHQVSLLARFNQDLDKV 330 340 350 360 370 380 420 430 440 450 460 470 pF1KB7 SSIGLTYFQSSNLQCSTCTYKIQRLMLKSLTYPERPPLCRYNIVLKDREEVFLNPNTCTP ..:.: .:....: .: :. :.::..:::: ::::..:: . :. ..: : NP_640 AAISL-MFSTGSLIGPRYKLRILRMKLRSLAHPERPQLCRYDLVLMENVETVFQPILCPE 390 400 410 420 430 440 480 pF1KB7 KNT NP_640 LQL 450 >>XP_011510832 (OMIM: 604379,607365) PREDICTED: lipase m (408 aa) initn: 1322 init1: 1030 opt: 1357 Z-score: 1651.4 bits: 314.7 E(85289): 3e-85 Smith-Waterman score: 1357; 47.7% identity (79.3% similar) in 411 aa overlap (67-476:1-403) 40 50 60 70 80 90 pF1KB7 DNKRPCLEFSQLSVKDSFRDLFIPRIETILMMYTRNNLNCAEPLFEQNNSLNVNFNTQKK :.:::.::.::. . :.: :.:. :: XP_011 MLYTRKNLTCAQTI---NSSAFGNLNVTKK 10 20 100 110 120 130 140 150 pF1KB7 TVWLIHGYRPVGSIPLWLQNFVRILLNEEDMNVIVVDWSRGATTFIYNRAVKNTRKVAVS :....::.::.:: :.:....:. ::. :::::.::::.:::::.::..: ..:::::. XP_011 TTFIVHGFRPTGSPPVWMDDLVKGLLSVEDMNVVVVDWNRGATTLIYTHASSKTRKVAMV 30 40 50 60 70 80 160 170 180 190 200 210 pF1KB7 LSVHIKNLLKHGASLDNFHFIGVSLGAHISGFVGKIFHGQLGRITGLDPAGPRFSRKPPY :. : ..: .:::::....::::::::::::::... : :::::::::::: :. :: XP_011 LKEFIDQMLAEGASLDDIYMIGVSLGAHISGFVGEMYDGWLGRITGLDPAGPLFNGKPHQ 90 100 110 120 130 140 220 230 240 250 260 270 pF1KB7 SRLDYTDAKFVDVIHSDSNGLGIQEPLGHIDFYPNGGNKQPGCPKSIFSGIQFIKCNHQR .::: .::.::::::::...:: .::::.:::::::: ::::::.:..:.:..::.::: XP_011 DRLDPSDAQFVDVIHSDTDALGYKEPLGNIDFYPNGGLDQPGCPKTILGGFQYFKCDHQR 150 160 170 180 190 200 280 290 300 310 320 330 pF1KB7 AVHLFMASLETNCNFISFPCRSYKDYKTSLCVDCDCFKEKSCPRLGYQAKLFKGVLKERM .:.:...::. .:.. ..:: ::.::... ::.: ...::: ::: : .: ... XP_011 SVYLYLSSLRESCTITAYPCDSYQDYRNGKCVSCGTSQKESCPLLGYYADNWK----DHL 210 220 230 240 250 260 340 350 360 370 380 390 pF1KB7 EGR-PLRTTVFLDTSGTYPFCTYYFVLSIIVPDKTMMDGSFSFKLLNQLGMIEEPRLYEK .:. : : .:.::. ::: :.. ..::. .:.. :....:: .. : : .. .. XP_011 RGKDPPMTKAFFDTAEESPFCMYHYFVDIITWNKNVRRGDITIKLRDKAGNTTESKINHE 270 280 290 300 310 320 400 410 420 430 440 450 pF1KB7 NKPFYKLQEVKILAQFYNDFVNISSIGLTYFQSSNLQCSTCTYKIQRLMLKSLTYPERPP : : ..:..::.: .:. ....:.: .:....: .: :. :.::..:::: XP_011 PTTFQKYHQVSLLARFNQDLDKVAAISL-MFSTGSLIGPRYKLRILRMKLRSLAHPERPQ 330 340 350 360 370 380 460 470 480 pF1KB7 LCRYNIVLKDREEVFLNPNTCTPKNT ::::..:: . :. ..: : XP_011 LCRYDLVLMENVETVFQPILCPELQL 390 400 >>XP_011510833 (OMIM: 604379,607365) PREDICTED: lipase m (408 aa) initn: 1322 init1: 1030 opt: 1357 Z-score: 1651.4 bits: 314.7 E(85289): 3e-85 Smith-Waterman score: 1357; 47.7% identity (79.3% similar) in 411 aa overlap (67-476:1-403) 40 50 60 70 80 90 pF1KB7 DNKRPCLEFSQLSVKDSFRDLFIPRIETILMMYTRNNLNCAEPLFEQNNSLNVNFNTQKK :.:::.::.::. . :.: :.:. :: XP_011 MLYTRKNLTCAQTI---NSSAFGNLNVTKK 10 20 100 110 120 130 140 150 pF1KB7 TVWLIHGYRPVGSIPLWLQNFVRILLNEEDMNVIVVDWSRGATTFIYNRAVKNTRKVAVS :....::.::.:: :.:....:. ::. :::::.::::.:::::.::..: ..:::::. XP_011 TTFIVHGFRPTGSPPVWMDDLVKGLLSVEDMNVVVVDWNRGATTLIYTHASSKTRKVAMV 30 40 50 60 70 80 160 170 180 190 200 210 pF1KB7 LSVHIKNLLKHGASLDNFHFIGVSLGAHISGFVGKIFHGQLGRITGLDPAGPRFSRKPPY :. : ..: .:::::....::::::::::::::... : :::::::::::: :. :: XP_011 LKEFIDQMLAEGASLDDIYMIGVSLGAHISGFVGEMYDGWLGRITGLDPAGPLFNGKPHQ 90 100 110 120 130 140 220 230 240 250 260 270 pF1KB7 SRLDYTDAKFVDVIHSDSNGLGIQEPLGHIDFYPNGGNKQPGCPKSIFSGIQFIKCNHQR .::: .::.::::::::...:: .::::.:::::::: ::::::.:..:.:..::.::: XP_011 DRLDPSDAQFVDVIHSDTDALGYKEPLGNIDFYPNGGLDQPGCPKTILGGFQYFKCDHQR 150 160 170 180 190 200 280 290 300 310 320 330 pF1KB7 AVHLFMASLETNCNFISFPCRSYKDYKTSLCVDCDCFKEKSCPRLGYQAKLFKGVLKERM .:.:...::. .:.. ..:: ::.::... ::.: ...::: ::: : .: ... XP_011 SVYLYLSSLRESCTITAYPCDSYQDYRNGKCVSCGTSQKESCPLLGYYADNWK----DHL 210 220 230 240 250 260 340 350 360 370 380 390 pF1KB7 EGR-PLRTTVFLDTSGTYPFCTYYFVLSIIVPDKTMMDGSFSFKLLNQLGMIEEPRLYEK .:. : : .:.::. ::: :.. ..::. .:.. :....:: .. : : .. .. XP_011 RGKDPPMTKAFFDTAEESPFCMYHYFVDIITWNKNVRRGDITIKLRDKAGNTTESKINHE 270 280 290 300 310 320 400 410 420 430 440 450 pF1KB7 NKPFYKLQEVKILAQFYNDFVNISSIGLTYFQSSNLQCSTCTYKIQRLMLKSLTYPERPP : : ..:..::.: .:. ....:.: .:....: .: :. :.::..:::: XP_011 PTTFQKYHQVSLLARFNQDLDKVAAISL-MFSTGSLIGPRYKLRILRMKLRSLAHPERPQ 330 340 350 360 370 380 460 470 480 pF1KB7 LCRYNIVLKDREEVFLNPNTCTPKNT ::::..:: . :. ..: : XP_011 LCRYDLVLMENVETVFQPILCPELQL 390 400 >>NP_056984 (OMIM: 607460) phospholipase A1 member A iso (456 aa) initn: 817 init1: 652 opt: 867 Z-score: 1054.9 bits: 204.5 E(85289): 5.1e-52 Smith-Waterman score: 867; 39.6% identity (70.7% similar) in 338 aa overlap (26-359:16-340) 10 20 30 40 50 pF1KB7 MLLKCLHNNLCQKYSAHAFQFSPRNVLWLLVVCLRSDNKRP---CLEFSQLSVKDSFRDL .::: : . : : .:.. .. .. :: NP_056 MPPGPWESCFWVGGLILWLSVGSSGDAPPTPQPKCADFQSANLFEG-TDL 10 20 30 40 60 70 80 90 100 110 pF1KB7 FIPRIETILMMYTRNNLNCAEPLFEQNNSL-NVNFNTQKKTVWLIHGYRPVGSIPLWLQN . ..... .: .:.. : : ...: : .::. : .:::.: .:. : :... NP_056 KVQ-----FLLFVPSNPSCGQ-LVEGSSDLQNSGFNATLGTKLIIHGFRVLGTKPSWIDT 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB7 FVRILLNEEDMNVIVVDWSRGATTFIYNRAVKNTRKVAVSLSVHIKNLLKHGASLDNFHF :.: :: . :::.::: :.: .: ::::. :... .:. ...:: :.: ...:. NP_056 FIRTLLRATNANVIAVDWIYGSTG-VYFSAVKNVIKLSLEISLFLNKLLVLGVSESSIHI 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB7 IGVSLGAHISGFVGKIFHGQLGRITGLDPAGPRFSRKPPYSRLDYTDAKFVDVIHSDSNG ::::::::..:.::..: ::::.:::::::::...: ::: :: ::..::.:... NP_056 IGVSLGAHVGGMVGQLFGGQLGQITGLDPAGPEYTRASVEERLDAGDALFVEAIHTDTDN 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB7 LGIQEPLGHIDFYPNGGNKQPGCPKSIFSGIQFIKCNHQRAVHLFMASLETNCNFISFPC :::. :.::.:.. :::. ::::: ...: ... :.:.:::::....::..: ...::: NP_056 LGIRIPVGHVDYFVNGGQDQPGCPTFFYAGYSYLICDHMRAVHLYISALENSCPLMAFPC 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB7 RSYKDYKTSLCVDCDCFKEKSCPRLGYQAKLFKGVLKERMEGRPLRTTVFLDTSGTYPFC ::: . .. :.:: ::::.: . :: ..: : .. :.: :... :.: NP_056 ASYKAFLAGRCLDCFNPFLLSCPRIGLVEQ--GGV---KIEPLPKEVKVYLLTTSSAPYC 290 300 310 320 330 360 370 380 390 400 410 pF1KB7 TYYFVLSIIVPDKTMMDGSFSFKLLNQLGMIEEPRLYEKNKPFYKLQEVKILAQFYNDFV .. NP_056 MHHSLVEFHLKELRNKDTNIEVTFLSSNITSSSKITIPKQQRYGKGIIAHATPQCQINQV 340 350 360 370 380 390 481 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 06:11:48 2016 done: Fri Nov 4 06:11:50 2016 Total Scan time: 8.970 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]