FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7238, 118 aa 1>>>pF1KB7238 118 - 118 aa - 118 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.9829+/-0.000271; mu= 1.3928+/- 0.017 mean_var=214.9973+/-41.884, 0's: 0 Z-trim(127.0): 36 B-trim: 52 in 1/57 Lambda= 0.087470 statistics sampled from 54343 (54384) to 54343 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.873), E-opt: 0.2 (0.638), width: 16 Scan time: 5.110 The best scores are: opt bits E(85289) NP_848131 (OMIM: 612608) late cornified envelope p ( 118) 988 134.9 2.8e-32 NP_848130 (OMIM: 612607) late cornified envelope p ( 118) 934 128.1 3.2e-30 NP_848128 (OMIM: 612605) late cornified envelope p ( 118) 928 127.4 5.4e-30 NP_848126 (OMIM: 612604) late cornified envelope p ( 118) 901 124.0 5.7e-29 NP_848129 (OMIM: 612606) late cornified envelope p ( 114) 848 117.3 5.8e-27 NP_848125 (OMIM: 612603) late cornified envelope p ( 110) 835 115.6 1.8e-26 NP_848517 (OMIM: 612612) late cornified envelope p ( 110) 648 92.0 2.2e-19 NP_848525 (OMIM: 612619) late cornified envelope p ( 118) 640 91.0 4.7e-19 NP_055172 (OMIM: 612610) late cornified envelope p ( 110) 630 89.7 1.1e-18 NP_848515 (OMIM: 612609) late cornified envelope p ( 106) 627 89.3 1.4e-18 NP_848516 (OMIM: 612611) late cornified envelope p ( 110) 626 89.2 1.5e-18 NP_001263260 (OMIM: 612605) late cornified envelop ( 88) 544 78.8 1.7e-15 XP_011507023 (OMIM: 612618) PREDICTED: late cornif ( 175) 514 75.3 3.8e-14 NP_848133 (OMIM: 612618) late cornified envelope p ( 99) 412 62.2 1.9e-10 NP_848520 (OMIM: 612614) late cornified envelope p ( 95) 310 49.3 1.4e-06 NP_848521 (OMIM: 612615) late cornified envelope p ( 94) 297 47.6 4.3e-06 NP_115952 (OMIM: 612616) late cornified envelope p ( 92) 293 47.1 6e-06 NP_848522 (OMIM: 612617) late cornified envelope p ( 92) 288 46.5 9.3e-06 XP_011507786 (OMIM: 612617) PREDICTED: late cornif ( 92) 288 46.5 9.3e-06 NP_848518 (OMIM: 612613) late cornified envelope p ( 89) 231 39.3 0.0013 NP_001017418 (OMIM: 182268) small proline-rich pro ( 72) 225 38.4 0.0019 XP_016857663 (OMIM: 182268) PREDICTED: small proli ( 72) 225 38.4 0.0019 NP_005979 (OMIM: 182267) small proline-rich protei ( 72) 225 38.4 0.0019 NP_005544 (OMIM: 148021) keratin-associated protei ( 169) 227 39.1 0.003 >>NP_848131 (OMIM: 612608) late cornified envelope prote (118 aa) initn: 988 init1: 988 opt: 988 Z-score: 700.4 bits: 134.9 E(85289): 2.8e-32 Smith-Waterman score: 988; 100.0% identity (100.0% similar) in 118 aa overlap (1-118:1-118) 10 20 30 40 50 60 pF1KB7 MSCQQSQQQCQPPPKCTPKCPPKCPTPKCPPKCPPKCPPVSSCCSVSSGGCCGSSSGGCC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_848 MSCQQSQQQCQPPPKCTPKCPPKCPTPKCPPKCPPKCPPVSSCCSVSSGGCCGSSSGGCC 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 SSGGGGCCSSGGGGCCLSHHRRRRSHRHRPQSSDCCSQPSAGSSCCGGGSGQHSGGCC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_848 SSGGGGCCSSGGGGCCLSHHRRRRSHRHRPQSSDCCSQPSAGSSCCGGGSGQHSGGCC 70 80 90 100 110 >>NP_848130 (OMIM: 612607) late cornified envelope prote (118 aa) initn: 934 init1: 934 opt: 934 Z-score: 663.6 bits: 128.1 E(85289): 3.2e-30 Smith-Waterman score: 934; 94.1% identity (99.2% similar) in 118 aa overlap (1-118:1-118) 10 20 30 40 50 60 pF1KB7 MSCQQSQQQCQPPPKCTPKCPPKCPTPKCPPKCPPKCPPVSSCCSVSSGGCCGSSSGGCC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: : NP_848 MSCQQSQQQCQPPPKCTPKCPPKCPTPKCPPKCPPKCPPVSSCCSVSSGGCCGSSSGGSC 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 SSGGGGCCSSGGGGCCLSHHRRRRSHRHRPQSSDCCSQPSAGSSCCGGGSGQHSGGCC .:..:::::::::::::::::..:::::::::::::::::.::::::::::::::::: NP_848 GSSSGGCCSSGGGGCCLSHHRHHRSHRHRPQSSDCCSQPSGGSSCCGGGSGQHSGGCC 70 80 90 100 110 >>NP_848128 (OMIM: 612605) late cornified envelope prote (118 aa) initn: 928 init1: 928 opt: 928 Z-score: 659.5 bits: 127.4 E(85289): 5.4e-30 Smith-Waterman score: 928; 94.1% identity (97.5% similar) in 118 aa overlap (1-118:1-118) 10 20 30 40 50 60 pF1KB7 MSCQQSQQQCQPPPKCTPKCPPKCPTPKCPPKCPPKCPPVSSCCSVSSGGCCGSSSGGCC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: : NP_848 MSCQQSQQQCQPPPKCTPKCPPKCPTPKCPPKCPPKCPPVSSCCSVSSGGCCGSSSGGSC 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 SSGGGGCCSSGGGGCCLSHHRRRRSHRHRPQSSDCCSQPSAGSSCCGGGSGQHSGGCC .:..:::::::::::::::::::::: :::::: ::::::.::::::::::::::::: NP_848 GSSSGGCCSSGGGGCCLSHHRRRRSHCHRPQSSGCCSQPSGGSSCCGGGSGQHSGGCC 70 80 90 100 110 >>NP_848126 (OMIM: 612604) late cornified envelope prote (118 aa) initn: 901 init1: 901 opt: 901 Z-score: 641.1 bits: 124.0 E(85289): 5.7e-29 Smith-Waterman score: 901; 90.7% identity (95.8% similar) in 118 aa overlap (1-118:1-118) 10 20 30 40 50 60 pF1KB7 MSCQQSQQQCQPPPKCTPKCPPKCPTPKCPPKCPPKCPPVSSCCSVSSGGCCGSSSGGCC :::::.:::::::::: ::::::: ::.:::::::::::::::::::::::::::::: : NP_848 MSCQQNQQQCQPPPKCIPKCPPKCLTPRCPPKCPPKCPPVSSCCSVSSGGCCGSSSGGSC 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 SSGGGGCCSSGGGGCCLSHHRRRRSHRHRPQSSDCCSQPSAGSSCCGGGSGQHSGGCC .:..:::::::::::::::::::::: :::::: ::::::.::::::::::::::::: NP_848 GSSSGGCCSSGGGGCCLSHHRRRRSHCHRPQSSGCCSQPSGGSSCCGGGSGQHSGGCC 70 80 90 100 110 >>NP_848129 (OMIM: 612606) late cornified envelope prote (114 aa) initn: 719 init1: 719 opt: 848 Z-score: 605.1 bits: 117.3 E(85289): 5.8e-27 Smith-Waterman score: 848; 88.1% identity (94.9% similar) in 118 aa overlap (1-118:1-114) 10 20 30 40 50 60 pF1KB7 MSCQQSQQQCQPPPKCTPKCPPKCPTPKCPPKCPPKCPPVSSCCSVSSGGCCGSSSGGCC :::::::::::::::::::: ::::.:::::: :::::::::::::::::::::: : NP_848 MSCQQSQQQCQPPPKCTPKCTPKCPAPKCPPK----CPPVSSCCSVSSGGCCGSSSGGGC 10 20 30 40 50 70 80 90 100 110 pF1KB7 SSGGGGCCSSGGGGCCLSHHRRRRSHRHRPQSSDCCSQPSAGSSCCGGGSGQHSGGCC .:..::::::::::::::::::.::::.::::::::::::.:::::::::.::::::: NP_848 GSNSGGCCSSGGGGCCLSHHRRHRSHRRRPQSSDCCSQPSGGSSCCGGGSSQHSGGCC 60 70 80 90 100 110 >>NP_848125 (OMIM: 612603) late cornified envelope prote (110 aa) initn: 786 init1: 571 opt: 835 Z-score: 596.4 bits: 115.6 E(85289): 1.8e-26 Smith-Waterman score: 835; 89.0% identity (90.7% similar) in 118 aa overlap (1-118:1-110) 10 20 30 40 50 60 pF1KB7 MSCQQSQQQCQPPPKCTPKCPPKCPTPKCPPKCPPKCPPVSSCCSVSSGGCCGSSSGGCC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_848 MSCQQSQQQCQPPPKCTPKCPPKCPTPKCPPKCPPKCPPVSSCCSVSSGGCCGSSSGG-- 10 20 30 40 50 70 80 90 100 110 pF1KB7 SSGGGGCCSSGGGGCCLSHHRRRRSHRHRPQSSDCCSQPSAGSSCCGGGSGQHSGGCC :: ::::::::::::::.:::::: ::: ::::::.::::::: ::::::::: NP_848 -----GC-SSGGGGCCLSHHRRHRSHRHRLQSSGCCSQPSGGSSCCGGDSGQHSGGCC 60 70 80 90 100 110 >>NP_848517 (OMIM: 612612) late cornified envelope prote (110 aa) initn: 553 init1: 410 opt: 648 Z-score: 468.9 bits: 92.0 E(85289): 2.2e-19 Smith-Waterman score: 648; 67.2% identity (80.7% similar) in 119 aa overlap (1-118:1-110) 10 20 30 40 50 60 pF1KB7 MSCQQSQQQCQPPPKCTPKCPPKCPTPKCPPKCPPKCPPVSSCCSVSSGGCCGSSSGGCC :::::.:::::::::: ::: :::: :::::::::.:: . :: . ..::: :::.:: NP_848 MSCQQNQQQCQPPPKCPPKCTPKCP-PKCPPKCPPQCP---APCSPAVSSCCGPSSGSCC 10 20 30 40 50 70 80 90 100 110 pF1KB7 SSGGGGCCSSGGGGCCLSHHRRRRSHRHRPQSSDCC-SQPSAGSSCCGGGSGQHSGGCC . ..::::::::::::::::: : ::.: :: ::: :.::..:.:: . ::::: NP_848 GPSSGGCCSSGGGGCCLSHHRPRLFHRRRHQSPDCCESEPSGASGCC-----HSSGGCC 60 70 80 90 100 110 >>NP_848525 (OMIM: 612619) late cornified envelope prote (118 aa) initn: 398 init1: 398 opt: 640 Z-score: 463.1 bits: 91.0 E(85289): 4.7e-19 Smith-Waterman score: 640; 69.3% identity (77.2% similar) in 127 aa overlap (1-118:1-118) 10 20 30 40 50 pF1KB7 MSCQQSQQQCQPPPKCTPKCPPKCPTPKCPPKCPPKCPP-VSSCCSVSSGGCCGSSSGGC :::::::::::::::::::::::: :::::::::::::: :. : ..::::::::: NP_848 MSCQQSQQQCQPPPKCTPKCPPKC-TPKCPPKCPPKCPPQCSAPCPPPVSSCCGSSSGGC 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 CSSGGGGCCSSGGGGCCLSHHRRRRSHRHRPQSSDCCS----QPSAGSSCC--GGGSG-- ::: :: :::::::: :.: :.:::::.::. : :.::::: .:::: NP_848 CSSEGG--------GCCLSHHRPRQSLRRRPQSSSCCGSGSGQQSGGSSCCHSSGGSGCC 60 70 80 90 100 110 pF1KB7 QHSGGCC . ::::: NP_848 HSSGGCC >>NP_055172 (OMIM: 612610) late cornified envelope prote (110 aa) initn: 532 init1: 399 opt: 630 Z-score: 456.6 bits: 89.7 E(85289): 1.1e-18 Smith-Waterman score: 630; 65.5% identity (79.0% similar) in 119 aa overlap (1-118:1-110) 10 20 30 40 50 60 pF1KB7 MSCQQSQQQCQPPPKCTPKCPPKCPTPKCPPKCPPKCPPVSSCCSVSSGGCCGSSSGGCC :::::.:::::::::: ::: :::: ::::::: :.:: . :: . ..::: ::::: NP_055 MSCQQNQQQCQPPPKCPPKCTPKCP-PKCPPKCLPQCP---APCSPAVSSCCGPISGGCC 10 20 30 40 50 70 80 90 100 110 pF1KB7 SSGGGGCCSSGGGGCCLSHHRRRRSHRHRPQSSDCC-SQPSAGSSCCGGGSGQHSGGCC . ..::::.::.::::::::: : ::.: :: ::: :.::.::.:: . ::::: NP_055 GPSSGGCCNSGAGGCCLSHHRPRLFHRRRHQSPDCCESEPSGGSGCC-----HSSGGCC 60 70 80 90 100 110 >>NP_848515 (OMIM: 612609) late cornified envelope prote (106 aa) initn: 456 init1: 456 opt: 627 Z-score: 454.8 bits: 89.3 E(85289): 1.4e-18 Smith-Waterman score: 645; 70.0% identity (75.8% similar) in 120 aa overlap (1-118:1-106) 10 20 30 40 50 pF1KB7 MSCQQSQQQCQPPPKCTPKCPPKCPTPKCPPKCPPKCPP-VSSCCSVSSGGCCGSSSGGC :::::.:::::::::: :::::::: ::: :.:: ::: :::::. ::::::::::::: NP_848 MSCQQNQQQCQPPPKCPPKCPPKCP-PKCRPQCPAPCPPPVSSCCGPSSGGCCGSSSGGC 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 CSSGGGGCCSSGGGGCCLSHHRRRRSHRHRPQSSDCCS-QPSAGSSCCGGGSGQHSGGCC :::::: :::::::: : :::: :: ::: .::.::.:: . :: :: NP_848 CSSGGG--------GCCLSHHRPRLFHRHRHQSPDCCECEPSGGSGCC-----HSSGDCC 60 70 80 90 100 118 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 06:13:06 2016 done: Fri Nov 4 06:13:07 2016 Total Scan time: 5.110 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]