FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7253, 419 aa 1>>>pF1KB7253 419 - 419 aa - 419 aa Library: /omim/omim.rfq.tfa 64369986 residues in 92320 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.4370+/-0.000354; mu= -5.8250+/- 0.022 mean_var=314.6254+/-63.726, 0's: 0 Z-trim(123.3): 14 B-trim: 14 in 1/54 Lambda= 0.072307 statistics sampled from 44674 (44689) to 44674 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.791), E-opt: 0.2 (0.484), width: 16 Scan time: 4.750 The best scores are: opt bits E(92320) NP_056432 (OMIM: 606902) pygopus homolog 1 isoform ( 419) 2981 324.3 3.8e-88 NP_001354735 (OMIM: 606902) pygopus homolog 1 isof ( 419) 2883 314.1 4.6e-85 NP_001317255 (OMIM: 606902) pygopus homolog 1 isof ( 419) 2883 314.1 4.6e-85 NP_612157 (OMIM: 606903) pygopus homolog 2 [Homo s ( 406) 556 71.3 5.3e-12 >>NP_056432 (OMIM: 606902) pygopus homolog 1 isoform 1 [ (419 aa) initn: 2981 init1: 2981 opt: 2981 Z-score: 1704.0 bits: 324.3 E(92320): 3.8e-88 Smith-Waterman score: 2981; 100.0% identity (100.0% similar) in 419 aa overlap (1-419:1-419) 10 20 30 40 50 60 pF1KB7 MPAENSPAPAYKVSSHGGDSGLDGLGGPGVQLGSPDKKKRKANTQGPSFPPLSEYAPPPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 MPAENSPAPAYKVSSHGGDSGLDGLGGPGVQLGSPDKKKRKANTQGPSFPPLSEYAPPPN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 PNSDHLVAANPFDDNYNTISYKPLPSSNPYLGPGYPGFGGYSTFRMPPHVPPRMSSPYCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 PNSDHLVAANPFDDNYNTISYKPLPSSNPYLGPGYPGFGGYSTFRMPPHVPPRMSSPYCG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 PYSLRNQPHPFPQNPLGMGFNRPHAFNFGPHDNSSFGNPSYNNALSQNVNMPNQHFRQNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 PYSLRNQPHPFPQNPLGMGFNRPHAFNFGPHDNSSFGNPSYNNALSQNVNMPNQHFRQNP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 AENFSQIPPQNASQVSNPDLASNFVPGNNSNFTSPLESNHSFIPPPNTFGQAKAPPPKQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 AENFSQIPPQNASQVSNPDLASNFVPGNNSNFTSPLESNHSFIPPPNTFGQAKAPPPKQD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 FTQGATKNTNQNSSAHPPHLNMDDTVNQSNIELKNVNRNNAVNQENSRSSSTEATNNNPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 FTQGATKNTNQNSSAHPPHLNMDDTVNQSNIELKNVNRNNAVNQENSRSSSTEATNNNPA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 NGTQNKPRQPRGAADACTTEKSNKSSLHPNRHGHSSSDPVYPCGICTNEVNDDQDAILCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 NGTQNKPRQPRGAADACTTEKSNKSSLHPNRHGHSSSDPVYPCGICTNEVNDDQDAILCE 310 320 330 340 350 360 370 380 390 400 410 pF1KB7 ASCQKWFHRICTGMTETAYGLLTAEASAVWGCDTCMADKDVQLMRTRETFGPSAVGSDA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 ASCQKWFHRICTGMTETAYGLLTAEASAVWGCDTCMADKDVQLMRTRETFGPSAVGSDA 370 380 390 400 410 >>NP_001354735 (OMIM: 606902) pygopus homolog 1 isoform (419 aa) initn: 2883 init1: 2883 opt: 2883 Z-score: 1648.8 bits: 314.1 E(92320): 4.6e-85 Smith-Waterman score: 2883; 97.1% identity (97.6% similar) in 419 aa overlap (1-419:1-419) 10 20 30 40 50 60 pF1KB7 MPAENSPAPAYKVSSHGGDSGLDGLGGPGVQLGSPDKKKRKANTQGPSFPPLSEYAPPPN : ::. : .:::::::::::::::::::::::::::::::::::::::::::: NP_001 MSAEQEKDPISLKRVRGGDSGLDGLGGPGVQLGSPDKKKRKANTQGPSFPPLSEYAPPPN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 PNSDHLVAANPFDDNYNTISYKPLPSSNPYLGPGYPGFGGYSTFRMPPHVPPRMSSPYCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PNSDHLVAANPFDDNYNTISYKPLPSSNPYLGPGYPGFGGYSTFRMPPHVPPRMSSPYCG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 PYSLRNQPHPFPQNPLGMGFNRPHAFNFGPHDNSSFGNPSYNNALSQNVNMPNQHFRQNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PYSLRNQPHPFPQNPLGMGFNRPHAFNFGPHDNSSFGNPSYNNALSQNVNMPNQHFRQNP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 AENFSQIPPQNASQVSNPDLASNFVPGNNSNFTSPLESNHSFIPPPNTFGQAKAPPPKQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AENFSQIPPQNASQVSNPDLASNFVPGNNSNFTSPLESNHSFIPPPNTFGQAKAPPPKQD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 FTQGATKNTNQNSSAHPPHLNMDDTVNQSNIELKNVNRNNAVNQENSRSSSTEATNNNPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FTQGATKNTNQNSSAHPPHLNMDDTVNQSNIELKNVNRNNAVNQENSRSSSTEATNNNPA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 NGTQNKPRQPRGAADACTTEKSNKSSLHPNRHGHSSSDPVYPCGICTNEVNDDQDAILCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NGTQNKPRQPRGAADACTTEKSNKSSLHPNRHGHSSSDPVYPCGICTNEVNDDQDAILCE 310 320 330 340 350 360 370 380 390 400 410 pF1KB7 ASCQKWFHRICTGMTETAYGLLTAEASAVWGCDTCMADKDVQLMRTRETFGPSAVGSDA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASCQKWFHRICTGMTETAYGLLTAEASAVWGCDTCMADKDVQLMRTRETFGPSAVGSDA 370 380 390 400 410 >>NP_001317255 (OMIM: 606902) pygopus homolog 1 isoform (419 aa) initn: 2883 init1: 2883 opt: 2883 Z-score: 1648.8 bits: 314.1 E(92320): 4.6e-85 Smith-Waterman score: 2883; 97.1% identity (97.6% similar) in 419 aa overlap (1-419:1-419) 10 20 30 40 50 60 pF1KB7 MPAENSPAPAYKVSSHGGDSGLDGLGGPGVQLGSPDKKKRKANTQGPSFPPLSEYAPPPN : ::. : .:::::::::::::::::::::::::::::::::::::::::::: NP_001 MSAEQEKDPISLKRVRGGDSGLDGLGGPGVQLGSPDKKKRKANTQGPSFPPLSEYAPPPN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 PNSDHLVAANPFDDNYNTISYKPLPSSNPYLGPGYPGFGGYSTFRMPPHVPPRMSSPYCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PNSDHLVAANPFDDNYNTISYKPLPSSNPYLGPGYPGFGGYSTFRMPPHVPPRMSSPYCG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 PYSLRNQPHPFPQNPLGMGFNRPHAFNFGPHDNSSFGNPSYNNALSQNVNMPNQHFRQNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PYSLRNQPHPFPQNPLGMGFNRPHAFNFGPHDNSSFGNPSYNNALSQNVNMPNQHFRQNP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 AENFSQIPPQNASQVSNPDLASNFVPGNNSNFTSPLESNHSFIPPPNTFGQAKAPPPKQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AENFSQIPPQNASQVSNPDLASNFVPGNNSNFTSPLESNHSFIPPPNTFGQAKAPPPKQD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 FTQGATKNTNQNSSAHPPHLNMDDTVNQSNIELKNVNRNNAVNQENSRSSSTEATNNNPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FTQGATKNTNQNSSAHPPHLNMDDTVNQSNIELKNVNRNNAVNQENSRSSSTEATNNNPA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 NGTQNKPRQPRGAADACTTEKSNKSSLHPNRHGHSSSDPVYPCGICTNEVNDDQDAILCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NGTQNKPRQPRGAADACTTEKSNKSSLHPNRHGHSSSDPVYPCGICTNEVNDDQDAILCE 310 320 330 340 350 360 370 380 390 400 410 pF1KB7 ASCQKWFHRICTGMTETAYGLLTAEASAVWGCDTCMADKDVQLMRTRETFGPSAVGSDA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASCQKWFHRICTGMTETAYGLLTAEASAVWGCDTCMADKDVQLMRTRETFGPSAVGSDA 370 380 390 400 410 >>NP_612157 (OMIM: 606903) pygopus homolog 2 [Homo sapie (406 aa) initn: 634 init1: 407 opt: 556 Z-score: 337.1 bits: 71.3 E(92320): 5.3e-12 Smith-Waterman score: 874; 37.6% identity (59.2% similar) in 431 aa overlap (3-418:2-405) 10 20 30 40 50 pF1KB7 MPAENSPAPAYKVSSHGGD-------SGLDGLGGPGVQLGSPDKKKRKANTQGPSFPPLS : ..: : :. . :: : : :.:. ::.::.::.:::::.. :. NP_612 MAASAPPPPDKLEGGGGPAPPPAPPSTGRKQGKAGLQMKSPEKKRRKSNTQGPAYSHLT 10 20 30 40 50 60 70 80 90 100 110 pF1KB7 EYAPPPNPNSDHLVAANPFDDNYNTISYKPLPSSNPYLGPGYPGFGGYSTFR-MPPHVPP :.::::.: :::::.:::.:... . : .. :.:: : :::. . : .::: NP_612 EFAPPPTPMVDHLVASNPFEDDFG--APKVGVAAPPFLGSPVP-FGGFRVQGGMAGQVPP 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 RMSSPYCG-PYSLRNQPHPFPQNPLGMGFNRP-HAFNFGPHDNSSFGNPSYNNALSQNVN .:. : : :: :: ::: ::.: .:: : .. .. : : .: . .:. :.:: . NP_612 GYSTGGGGGPQPLRRQPPPFPPNPMGPAFNMPPQGPGYPPPGNMNFPSQPFNQPLGQNFS 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB7 MPNQHFRQNPAENFSQIPPQNASQVSNPDLASNFVPGNNSNFTSPLESNHSFIPPPNTFG :. .. .:. .:. :. . ...: : .: .. : : :: NP_612 PPSGQMMPGPVGGFG---PMISPTMGQPPRAE----------LGPPSLSQRFAQPGAPFG 180 190 200 210 220 240 250 260 270 280 pF1KB7 QAKAPPPKQDFTQGATKNTNQNSSAHP-PHLNMDDTVNQSNIELKNVNRNNAVNQENSRS : : : :: . :.: : : .. .... . : ..: :: . NP_612 ----PSPLQRPGQG-LPSLPPNTSPFPGPDPGFPGPGGEDGGKPLNPPASTAFPQEPHSG 230 240 250 260 270 290 300 310 320 330 340 pF1KB7 SSTEATNNNPANGTQNKPRQPRGAADACTTEKSNKSSLHPNRHGHSSSDP----VYPCGI : . :.:.: . :. . :. :: . .:.. : :. .: ::::: NP_612 SPAAAVNGNQPSFPPNSSGRGGGTPDANSLAPPGKAG------GGSGPQPPPGLVYPCGA 280 290 300 310 320 330 350 360 370 380 390 400 pF1KB7 CTNEVNDDQDAILCEASCQKWFHRICTGMTETAYGLLTAEASAVWGCDTCMADKDVQLMR : .::::::::::::::::::::: ::::::.::::::.::::::.:: :. :..: . NP_612 CRSEVNDDQDAILCEASCQKWFHRECTGMTESAYGLLTTEASAVWACDLCLKTKEIQSVY 340 350 360 370 380 390 410 pF1KB7 TRETFGPSAVGSDA :: .: ....: NP_612 IREGMGQLVAANDG 400 419 residues in 1 query sequences 64369986 residues in 92320 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Oct 24 21:57:08 2019 done: Thu Oct 24 21:57:09 2019 Total Scan time: 4.750 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]