FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7259, 586 aa 1>>>pF1KB7259 586 - 586 aa - 586 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.7001+/-0.000331; mu= 3.8374+/- 0.021 mean_var=185.8299+/-38.169, 0's: 0 Z-trim(121.3): 27 B-trim: 45 in 1/57 Lambda= 0.094084 statistics sampled from 37646 (37673) to 37646 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.761), E-opt: 0.2 (0.442), width: 16 Scan time: 13.020 The best scores are: opt bits E(85289) NP_542179 (OMIM: 300482) GRB2-associated-binding p ( 586) 3978 552.3 1.6e-156 NP_001075042 (OMIM: 300482) GRB2-associated-bindin ( 587) 3966 550.7 5e-156 XP_005274705 (OMIM: 300482) PREDICTED: GRB2-associ ( 587) 3966 550.7 5e-156 XP_006724867 (OMIM: 300482) PREDICTED: GRB2-associ ( 587) 3966 550.7 5e-156 XP_016884765 (OMIM: 300482) PREDICTED: GRB2-associ ( 609) 3966 550.7 5.1e-156 XP_011529405 (OMIM: 300482) PREDICTED: GRB2-associ ( 611) 3966 550.7 5.1e-156 XP_011529407 (OMIM: 300482) PREDICTED: GRB2-associ ( 587) 3961 550.0 8e-156 NP_001269212 (OMIM: 300482) GRB2-associated-bindin ( 548) 3476 484.2 4.9e-136 XP_011529408 (OMIM: 300482) PREDICTED: GRB2-associ ( 572) 3476 484.2 5.1e-136 NP_536739 (OMIM: 606203) GRB2-associated-binding p ( 676) 581 91.3 1.1e-17 NP_002030 (OMIM: 604439) GRB2-associated-binding p ( 694) 576 90.6 1.9e-17 NP_997006 (OMIM: 604439) GRB2-associated-binding p ( 724) 576 90.6 1.9e-17 XP_016863457 (OMIM: 604439) PREDICTED: GRB2-associ ( 711) 446 72.9 3.9e-12 XP_016863455 (OMIM: 604439) PREDICTED: GRB2-associ ( 738) 439 72.0 7.8e-12 XP_016863456 (OMIM: 604439) PREDICTED: GRB2-associ ( 734) 435 71.5 1.1e-11 XP_011543710 (OMIM: 606203) PREDICTED: GRB2-associ ( 456) 422 69.6 2.6e-11 XP_006718816 (OMIM: 606203) PREDICTED: GRB2-associ ( 638) 354 60.4 2.1e-08 NP_036428 (OMIM: 606203) GRB2-associated-binding p ( 638) 354 60.4 2.1e-08 >>NP_542179 (OMIM: 300482) GRB2-associated-binding prote (586 aa) initn: 3978 init1: 3978 opt: 3978 Z-score: 2931.0 bits: 552.3 E(85289): 1.6e-156 Smith-Waterman score: 3978; 100.0% identity (100.0% similar) in 586 aa overlap (1-586:1-586) 10 20 30 40 50 60 pF1KB7 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_542 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_542 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 LEDGADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_542 LEDGADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLFL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 PDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSCH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_542 PDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSCH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 GSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_542 GSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKEL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 DIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_542 DIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVEG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 QSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_542 QSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNSG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB7 SISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_542 SISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTSF 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB7 LSPERNGINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_542 LSPERNGINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFNS 490 500 510 520 530 540 550 560 570 580 pF1KB7 ASPAPMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKV :::::::::::::::::::::::::::::::::::::::::::::: NP_542 ASPAPMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKV 550 560 570 580 >>NP_001075042 (OMIM: 300482) GRB2-associated-binding pr (587 aa) initn: 3113 init1: 3113 opt: 3966 Z-score: 2922.2 bits: 550.7 E(85289): 5e-156 Smith-Waterman score: 3966; 99.8% identity (99.8% similar) in 587 aa overlap (1-586:1-587) 10 20 30 40 50 60 pF1KB7 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 LEDGA-DSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLF ::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEDGAADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLF 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 LPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSC 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB7 HGSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HGSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKE 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB7 LDIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVE 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB7 GQSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GQSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNS 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB7 GSISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTS 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB7 FLSPERNGINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FLSPERNGINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFN 490 500 510 520 530 540 540 550 560 570 580 pF1KB7 SASPAPMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKV ::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SASPAPMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKV 550 560 570 580 >>XP_005274705 (OMIM: 300482) PREDICTED: GRB2-associated (587 aa) initn: 3113 init1: 3113 opt: 3966 Z-score: 2922.2 bits: 550.7 E(85289): 5e-156 Smith-Waterman score: 3966; 99.8% identity (99.8% similar) in 587 aa overlap (1-586:1-587) 10 20 30 40 50 60 pF1KB7 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 LEDGA-DSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLF ::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LEDGAADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLF 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 LPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSC 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB7 HGSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HGSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKE 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB7 LDIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LDIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVE 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB7 GQSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GQSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNS 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB7 GSISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GSISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTS 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB7 FLSPERNGINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FLSPERNGINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFN 490 500 510 520 530 540 540 550 560 570 580 pF1KB7 SASPAPMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKV ::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SASPAPMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKV 550 560 570 580 >>XP_006724867 (OMIM: 300482) PREDICTED: GRB2-associated (587 aa) initn: 3113 init1: 3113 opt: 3966 Z-score: 2922.2 bits: 550.7 E(85289): 5e-156 Smith-Waterman score: 3966; 99.8% identity (99.8% similar) in 587 aa overlap (1-586:1-587) 10 20 30 40 50 60 pF1KB7 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 LEDGA-DSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLF ::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LEDGAADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLF 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 LPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSC 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB7 HGSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HGSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKE 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB7 LDIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LDIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVE 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB7 GQSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GQSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNS 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB7 GSISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GSISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTS 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB7 FLSPERNGINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FLSPERNGINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFN 490 500 510 520 530 540 540 550 560 570 580 pF1KB7 SASPAPMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKV ::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SASPAPMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKV 550 560 570 580 >>XP_016884765 (OMIM: 300482) PREDICTED: GRB2-associated (609 aa) initn: 3113 init1: 3113 opt: 3966 Z-score: 2922.0 bits: 550.7 E(85289): 5.1e-156 Smith-Waterman score: 3966; 99.8% identity (99.8% similar) in 587 aa overlap (1-586:1-587) 10 20 30 40 50 60 pF1KB7 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 LEDGA-DSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLF ::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LEDGAADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLF 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 LPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSC 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB7 HGSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HGSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKE 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB7 LDIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LDIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVE 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB7 GQSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GQSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNS 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB7 GSISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTS 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB7 FLSPERNGINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FLSPERNGINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFN 490 500 510 520 530 540 540 550 560 570 580 pF1KB7 SASPAPMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKV ::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SASPAPMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKVLGSRRPRMKVSVG 550 560 570 580 590 600 XP_016 HEVLFSVHS >>XP_011529405 (OMIM: 300482) PREDICTED: GRB2-associated (611 aa) initn: 3113 init1: 3113 opt: 3966 Z-score: 2922.0 bits: 550.7 E(85289): 5.1e-156 Smith-Waterman score: 3966; 99.8% identity (99.8% similar) in 587 aa overlap (1-586:1-587) 10 20 30 40 50 60 pF1KB7 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 LEDGA-DSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLF ::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LEDGAADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLF 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 LPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSC 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB7 HGSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HGSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKE 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB7 LDIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVE 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB7 GQSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GQSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNS 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB7 GSISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTS 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB7 FLSPERNGINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLSPERNGINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFN 490 500 510 520 530 540 540 550 560 570 580 pF1KB7 SASPAPMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKV ::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SASPAPMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKVKTKRECVVFKVLA 550 560 570 580 590 600 XP_011 RTFRKEDLFIH 610 >>XP_011529407 (OMIM: 300482) PREDICTED: GRB2-associated (587 aa) initn: 3108 init1: 3108 opt: 3961 Z-score: 2918.5 bits: 550.0 E(85289): 8e-156 Smith-Waterman score: 3961; 99.8% identity (99.8% similar) in 586 aa overlap (1-585:1-586) 10 20 30 40 50 60 pF1KB7 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 LEDGA-DSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLF ::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LEDGAADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLF 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 LPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSC 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB7 HGSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HGSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKE 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB7 LDIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVE 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB7 GQSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GQSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNS 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB7 GSISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTS 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB7 FLSPERNGINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLSPERNGINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFN 490 500 510 520 530 540 540 550 560 570 580 pF1KB7 SASPAPMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKV :::::::::::::::::::::::::::::::::::::::::::::: XP_011 SASPAPMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKK 550 560 570 580 >>NP_001269212 (OMIM: 300482) GRB2-associated-binding pr (548 aa) initn: 3508 init1: 2622 opt: 3476 Z-score: 2563.2 bits: 484.2 E(85289): 4.9e-136 Smith-Waterman score: 3626; 93.2% identity (93.2% similar) in 587 aa overlap (1-586:1-548) 10 20 30 40 50 60 pF1KB7 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 LEDGA-DSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLF ::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEDGAADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLF 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 LPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSC 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB7 HGSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HGSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKE 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB7 LDIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVE 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB7 GQSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GQSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNS 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB7 GSISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTS 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB7 FLSPERNGINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFN :::::::::::::::::::::::::::::: NP_001 FLSPERNGINSARFFANPVSREDEESYIEM------------------------------ 490 500 510 540 550 560 570 580 pF1KB7 SASPAPMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKV :::::::::::::::::::::::::::::::::::::: NP_001 ---------KLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKV 520 530 540 >>XP_011529408 (OMIM: 300482) PREDICTED: GRB2-associated (572 aa) initn: 3508 init1: 2622 opt: 3476 Z-score: 2562.9 bits: 484.2 E(85289): 5.1e-136 Smith-Waterman score: 3626; 93.2% identity (93.2% similar) in 587 aa overlap (1-586:1-548) 10 20 30 40 50 60 pF1KB7 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRVI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLGH 70 80 90 100 110 120 130 140 150 160 170 pF1KB7 LEDGA-DSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLF ::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LEDGAADSMESLSYTPSSLQPSSASSLLTAHAASSSLPRDDPNTNAVATEETRSESELLF 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 LPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPDYLVLSNCETGRLHHTSLPTRCDSWSNSDRSLEQASFDDVFVDCLQPLPSSHLVHPSC 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB7 HGSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HGSGAQEVPSSRPQAALIWSREINGPPRDHLSSSPLLESSLSSTIQVDKNQGSLPCGAKE 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB7 LDIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDIMSNTPPPRPPKPSHLSERRQEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKADVE 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB7 GQSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GQSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPDDYIPMNS 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB7 GSISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSISSPLPELPANLEPPPVNRDLKPQRKSRPPPLDLRNLSIIREHASLTRTRTVPCSRTS 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB7 FLSPERNGINSARFFANPVSREDEESYIEMEEHRTASSLSSGALTWTKKFSLDYLALDFN :::::::::::::::::::::::::::::: XP_011 FLSPERNGINSARFFANPVSREDEESYIEM------------------------------ 490 500 510 540 550 560 570 580 pF1KB7 SASPAPMQQKLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKV :::::::::::::::::::::::::::::::::::::: XP_011 ---------KLLLSEEQRVDYVQVDEQKTQALQSTKQEWTDERQSKVKTKRECVVFKVLA 520 530 540 550 560 XP_011 RTFRKEDLFIH 570 >>NP_536739 (OMIM: 606203) GRB2-associated-binding prote (676 aa) initn: 1020 init1: 368 opt: 581 Z-score: 438.2 bits: 91.3 E(85289): 1.1e-17 Smith-Waterman score: 901; 33.7% identity (57.5% similar) in 626 aa overlap (4-538:5-619) 10 20 30 40 50 pF1KB7 MSAGDAVCTGWLVKSPPERKLQRYAWRKRWFVLRRGRMSGNPDVLEYYRNKHSSKPIRV ::.:::::: :::::.::.::::.::::.:: :::::.:::::::.: ::.::.:. NP_536 MSGGGDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRI 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 IDLSECAVWKHVGPSFVRKEFQNNFVFIVKTTSRTFYLVAKTEQEMQVWVHSISQVCNLG :.:. : .: .: .::.:..::: .::. :::::::.::..:. ::.:: :.:... NP_536 INLNFCE-QVDAGLTFNKKELQDSFVFDIKTSERTFYLVAETEEDMNKWVQSICQICGFN 70 80 90 100 110 120 130 140 150 160 pF1KB7 HLEDGADSMESLSY-------TPSSLQPSSASSLLTAHAAS----SSLPR----DDPNTN . :...::....: .:. :. ::.. :: . .: :: : . : .: NP_536 QAEESTDSLRNVSSAGHGPRSSPAELS-SSSQHLLRERKSSAPSHSSQPTLFTFEPPVSN 120 130 140 150 160 170 170 180 190 200 210 pF1KB7 AVA-TEETRSESELLFLPDYLVLSNCETGRLHHTSLPTRCDSWSNSDR------------ . : : . .: :.: . :..: : :: . :: NP_536 HMQPTLSTSAPQEYLYL-HQCISRRAENARSASFSQGTRASFLMRSDTAVQKLAQGNGHC 180 190 200 210 220 230 220 230 240 250 pF1KB7 ------------SLEQASFDDV-FVDCLQPLPSSHLVHPSCHGS--GAQ----EVPSSR- :: . : .. : : :: : : .:: :.. .: . . NP_536 VNGISGQVHGFYSLPKPSRHNTEFRDSTYDLPRSLASHGHTKGSLTGSETDNEDVYTFKT 240 250 260 270 280 290 260 270 280 290 300 pF1KB7 PQAALIWSREINGPPRDHLS--SSPLLESSLSSTIQVDKNQGSLPCGAKELDIMSNTPPP :. .: ::.. :... ..:: .. :. .:::.... .. . .. ::: NP_536 PSNTL--CREFGDLLVDNMDVPATPLSAYQIPRTFTLDKNHNAMTVATPGDSAIA--PPP 300 310 320 330 340 350 310 320 330 340 350 pF1KB7 RPPKPSHLSERR----QEEWSTHSGSKKPECTLVPRRISLSGLDNMRTWKA--------- ::::::. : :.. .:.. : .::: .: ..:: : .: NP_536 RPPKPSQAETPRWGSPQQRPPISENSRSVAAT-IPRRNTLPAMDNSRLHRASSCETYEYP 360 370 380 390 400 410 360 370 380 390 400 410 pF1KB7 ----DVEGQSLRHRDKRLSLNLPCRFSPMYPTASASIEDSYVPMSPQAGASGLGPHCSPD . :.: . . .. :: .. . . :.. ::.::::.: :.: : NP_536 QRGGESAGRSAESMSDGVGSFLPGKMI-VGRSDSTNSEDNYVPMNP--GSSTLLAMERAG 420 430 440 450 460 420 430 440 450 pF1KB7 D-----YIPMNSG-----SISSPLPELPAN--------LEPPPVNRDLKPQRKSRPPPLD : ::::. : :.. : ::.. ..::::::.:::.::..: ::: NP_536 DNSQSVYIPMSPGAHHFDSLGYPSTTLPVHRGPSRGSEIQPPPVNRNLKPDRKAKPTPLD 470 480 490 500 510 520 460 470 480 490 500 510 pF1KB7 LRNLSIIRE---HASLTRTRTVPCSRTSFLSPERNGINSARFFANPVSREDEESYIEMEE ::: ..: : .. .:.. . . : . :.. ... : ..::.:. :.. NP_536 LRNNTVIDELPFKSPITKSWSRANHTFNSSSSQYCRPISTQSITSTDSGDSEENYVPMQN 530 540 550 560 570 580 520 530 540 550 560 pF1KB7 HRTASSLSSGALTWTKKFS---LDYLALDFNSASPAPMQQKLLLSEEQRVDYVQVDEQKT .:: . ::. . . : : .::::::: NP_536 PVSASPVPSGTNSPAPKKSTGSVDYLALDFQPSSPSPHRKPSTSSVTSDEKVDYVQVDKE 590 600 610 620 630 640 586 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 06:24:16 2016 done: Fri Nov 4 06:24:18 2016 Total Scan time: 13.020 Total Display time: 0.150 Function used was FASTA [36.3.4 Apr, 2011]