FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7262, 451 aa 1>>>pF1KB7262 451 - 451 aa - 451 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.0681+/-0.000305; mu= 11.8830+/- 0.019 mean_var=152.1140+/-29.903, 0's: 0 Z-trim(122.5): 105 B-trim: 0 in 0/53 Lambda= 0.103990 statistics sampled from 40669 (40782) to 40669 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.795), E-opt: 0.2 (0.478), width: 16 Scan time: 10.830 The best scores are: opt bits E(85289) NP_056239 (OMIM: 613127) chordin-like protein 2 is ( 451) 3335 511.6 1.7e-144 NP_001291319 (OMIM: 613127) chordin-like protein 2 ( 431) 3152 484.1 3e-136 NP_001265402 (OMIM: 613127) chordin-like protein 2 ( 429) 2790 429.8 6.7e-120 NP_001291346 (OMIM: 613127) chordin-like protein 2 ( 386) 2600 401.3 2.4e-111 NP_001291345 (OMIM: 613127) chordin-like protein 2 ( 313) 1893 295.1 1.7e-79 NP_001291344 (OMIM: 613127) chordin-like protein 2 ( 344) 1690 264.7 2.7e-70 NP_001291320 (OMIM: 613127) chordin-like protein 2 ( 366) 1690 264.7 2.9e-70 NP_660277 (OMIM: 300350) chordin-like protein 1 is ( 456) 1107 177.3 7.2e-44 XP_005262281 (OMIM: 300350) PREDICTED: chordin-lik ( 452) 1106 177.2 7.9e-44 NP_001137454 (OMIM: 300350) chordin-like protein 1 ( 457) 1105 177.1 8.9e-44 XP_005262279 (OMIM: 300350) PREDICTED: chordin-lik ( 457) 1105 177.1 8.9e-44 XP_005262280 (OMIM: 300350) PREDICTED: chordin-lik ( 453) 1100 176.3 1.5e-43 XP_016885448 (OMIM: 300350) PREDICTED: chordin-lik ( 453) 1100 176.3 1.5e-43 XP_005262278 (OMIM: 300350) PREDICTED: chordin-lik ( 458) 1099 176.2 1.7e-43 NP_001137453 (OMIM: 300350) chordin-like protein 1 ( 458) 1099 176.2 1.7e-43 NP_001137455 (OMIM: 300350) chordin-like protein 1 ( 378) 578 97.9 4.9e-20 XP_016867681 (OMIM: 609344) PREDICTED: kielin/chor (1347) 267 51.7 1.4e-05 XP_016867680 (OMIM: 609344) PREDICTED: kielin/chor (1347) 267 51.7 1.4e-05 XP_016867679 (OMIM: 609344) PREDICTED: kielin/chor (1466) 267 51.8 1.5e-05 XP_016867678 (OMIM: 609344) PREDICTED: kielin/chor (1526) 267 51.8 1.5e-05 XP_016867677 (OMIM: 609344) PREDICTED: kielin/chor (1555) 267 51.8 1.5e-05 XP_016867676 (OMIM: 609344) PREDICTED: kielin/chor (1615) 267 51.8 1.6e-05 XP_016867675 (OMIM: 609344) PREDICTED: kielin/chor (1615) 267 51.8 1.6e-05 XP_016867674 (OMIM: 609344) PREDICTED: kielin/chor (1628) 267 51.8 1.6e-05 XP_016867673 (OMIM: 609344) PREDICTED: kielin/chor (1633) 267 51.8 1.6e-05 XP_016862881 (OMIM: 603475) PREDICTED: chordin iso ( 866) 246 48.4 8.8e-05 XP_011511556 (OMIM: 603475) PREDICTED: chordin iso ( 867) 246 48.4 8.8e-05 XP_016862880 (OMIM: 603475) PREDICTED: chordin iso ( 893) 246 48.4 9e-05 XP_016862879 (OMIM: 603475) PREDICTED: chordin iso ( 894) 246 48.4 9e-05 NP_001291402 (OMIM: 603475) chordin isoform 3 [Hom ( 585) 233 46.3 0.00026 XP_011511558 (OMIM: 603475) PREDICTED: chordin iso ( 585) 233 46.3 0.00026 NP_001291403 (OMIM: 603475) chordin isoform 3 [Hom ( 585) 233 46.3 0.00026 XP_016862883 (OMIM: 603475) PREDICTED: chordin iso ( 633) 233 46.4 0.00027 NP_001291401 (OMIM: 603475) chordin isoform 2 prec ( 954) 233 46.5 0.00037 NP_003732 (OMIM: 603475) chordin isoform 1 precurs ( 955) 233 46.5 0.00037 XP_016862878 (OMIM: 603475) PREDICTED: chordin iso ( 981) 233 46.5 0.00037 XP_016862877 (OMIM: 603475) PREDICTED: chordin iso ( 982) 233 46.5 0.00037 XP_006718525 (OMIM: 611115) PREDICTED: von Willebr ( 895) 221 44.7 0.0012 XP_006718523 (OMIM: 611115) PREDICTED: von Willebr ( 947) 217 44.1 0.0019 NP_001129386 (OMIM: 609344) kielin/chordin-like pr (1503) 215 44.0 0.0033 XP_016872832 (OMIM: 611115) PREDICTED: von Willebr ( 672) 209 42.8 0.0034 XP_016872831 (OMIM: 611115) PREDICTED: von Willebr ( 825) 209 42.9 0.004 XP_016872830 (OMIM: 611115) PREDICTED: von Willebr ( 912) 209 42.9 0.0043 XP_016872829 (OMIM: 611115) PREDICTED: von Willebr ( 934) 209 42.9 0.0044 NP_689931 (OMIM: 611115) von Willebrand factor C a ( 955) 209 42.9 0.0044 XP_016859751 (OMIM: 606189) PREDICTED: cysteine-ri ( 714) 204 42.0 0.006 XP_016859750 (OMIM: 606189) PREDICTED: cysteine-ri ( 714) 204 42.0 0.006 XP_016867683 (OMIM: 609344) PREDICTED: kielin/chor (1093) 206 42.5 0.0067 XP_016867682 (OMIM: 609344) PREDICTED: kielin/chor (1102) 206 42.5 0.0067 XP_016859749 (OMIM: 606189) PREDICTED: cysteine-ri ( 955) 204 42.2 0.0075 >>NP_056239 (OMIM: 613127) chordin-like protein 2 isofor (451 aa) initn: 3335 init1: 3335 opt: 3335 Z-score: 2715.1 bits: 511.6 E(85289): 1.7e-144 Smith-Waterman score: 3335; 100.0% identity (100.0% similar) in 451 aa overlap (1-451:1-451) 10 20 30 40 50 60 pF1KB7 MVPEVRVLSSLLGLALLWFPLDSHARARPDMFCLFHGKRYSPGESWHPYLEPQGLMYCLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 MVPEVRVLSSLLGLALLWFPLDSHARARPDMFCLFHGKRYSPGESWHPYLEPQGLMYCLR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 CTCSEGAHVSCYRLHCPPVHCPQPVTEPQQCCPKCVEPHTPSGLRAPPKSCQHNGTMYQH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 CTCSEGAHVSCYRLHCPPVHCPQPVTEPQQCCPKCVEPHTPSGLRAPPKSCQHNGTMYQH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 GEIFSAHELFPSRLPNQCVLCSCTEGQIYCGLTTCPEPGCPAPLPLPDSCCQACKDEASE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 GEIFSAHELFPSRLPNQCVLCSCTEGQIYCGLTTCPEPGCPAPLPLPDSCCQACKDEASE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 QSDEEDSVQSLHGVRHPQDPCSSDAGRKRGPGTPAPTGLSAPLSFIPRHFRPKGAGSTTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 QSDEEDSVQSLHGVRHPQDPCSSDAGRKRGPGTPAPTGLSAPLSFIPRHFRPKGAGSTTV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 KIVLKEKHKKACVHGGKTYSHGEVWHPAFRAFGPLPCILCTCEDGRQDCQRVTCPTEYPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 KIVLKEKHKKACVHGGKTYSHGEVWHPAFRAFGPLPCILCTCEDGRQDCQRVTCPTEYPC 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 RHPEKVAGKCCKICPEDKADPGHSEISSTRCPKAPGRVLVHTSVSPSPDNLRRFALEHEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 RHPEKVAGKCCKICPEDKADPGHSEISSTRCPKAPGRVLVHTSVSPSPDNLRRFALEHEA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 SDLVEIYLWKLVKDEETEAQRGEVPGPRPHSQNLPLDSDQESQEARLPERGTALPTARWP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 SDLVEIYLWKLVKDEETEAQRGEVPGPRPHSQNLPLDSDQESQEARLPERGTALPTARWP 370 380 390 400 410 420 430 440 450 pF1KB7 PRRSLERLPSPDPGAEGHGQSRQSDQDITKT ::::::::::::::::::::::::::::::: NP_056 PRRSLERLPSPDPGAEGHGQSRQSDQDITKT 430 440 450 >>NP_001291319 (OMIM: 613127) chordin-like protein 2 iso (431 aa) initn: 3152 init1: 3152 opt: 3152 Z-score: 2567.0 bits: 484.1 E(85289): 3e-136 Smith-Waterman score: 3152; 100.0% identity (100.0% similar) in 423 aa overlap (29-451:9-431) 10 20 30 40 50 60 pF1KB7 MVPEVRVLSSLLGLALLWFPLDSHARARPDMFCLFHGKRYSPGESWHPYLEPQGLMYCLR :::::::::::::::::::::::::::::::: NP_001 MALVGLPGPDMFCLFHGKRYSPGESWHPYLEPQGLMYCLR 10 20 30 40 70 80 90 100 110 120 pF1KB7 CTCSEGAHVSCYRLHCPPVHCPQPVTEPQQCCPKCVEPHTPSGLRAPPKSCQHNGTMYQH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CTCSEGAHVSCYRLHCPPVHCPQPVTEPQQCCPKCVEPHTPSGLRAPPKSCQHNGTMYQH 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB7 GEIFSAHELFPSRLPNQCVLCSCTEGQIYCGLTTCPEPGCPAPLPLPDSCCQACKDEASE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GEIFSAHELFPSRLPNQCVLCSCTEGQIYCGLTTCPEPGCPAPLPLPDSCCQACKDEASE 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB7 QSDEEDSVQSLHGVRHPQDPCSSDAGRKRGPGTPAPTGLSAPLSFIPRHFRPKGAGSTTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSDEEDSVQSLHGVRHPQDPCSSDAGRKRGPGTPAPTGLSAPLSFIPRHFRPKGAGSTTV 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB7 KIVLKEKHKKACVHGGKTYSHGEVWHPAFRAFGPLPCILCTCEDGRQDCQRVTCPTEYPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KIVLKEKHKKACVHGGKTYSHGEVWHPAFRAFGPLPCILCTCEDGRQDCQRVTCPTEYPC 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB7 RHPEKVAGKCCKICPEDKADPGHSEISSTRCPKAPGRVLVHTSVSPSPDNLRRFALEHEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RHPEKVAGKCCKICPEDKADPGHSEISSTRCPKAPGRVLVHTSVSPSPDNLRRFALEHEA 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB7 SDLVEIYLWKLVKDEETEAQRGEVPGPRPHSQNLPLDSDQESQEARLPERGTALPTARWP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDLVEIYLWKLVKDEETEAQRGEVPGPRPHSQNLPLDSDQESQEARLPERGTALPTARWP 350 360 370 380 390 400 430 440 450 pF1KB7 PRRSLERLPSPDPGAEGHGQSRQSDQDITKT ::::::::::::::::::::::::::::::: NP_001 PRRSLERLPSPDPGAEGHGQSRQSDQDITKT 410 420 430 >>NP_001265402 (OMIM: 613127) chordin-like protein 2 iso (429 aa) initn: 2790 init1: 2790 opt: 2790 Z-score: 2273.5 bits: 429.8 E(85289): 6.7e-120 Smith-Waterman score: 2790; 100.0% identity (100.0% similar) in 373 aa overlap (1-373:1-373) 10 20 30 40 50 60 pF1KB7 MVPEVRVLSSLLGLALLWFPLDSHARARPDMFCLFHGKRYSPGESWHPYLEPQGLMYCLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MVPEVRVLSSLLGLALLWFPLDSHARARPDMFCLFHGKRYSPGESWHPYLEPQGLMYCLR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 CTCSEGAHVSCYRLHCPPVHCPQPVTEPQQCCPKCVEPHTPSGLRAPPKSCQHNGTMYQH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CTCSEGAHVSCYRLHCPPVHCPQPVTEPQQCCPKCVEPHTPSGLRAPPKSCQHNGTMYQH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 GEIFSAHELFPSRLPNQCVLCSCTEGQIYCGLTTCPEPGCPAPLPLPDSCCQACKDEASE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GEIFSAHELFPSRLPNQCVLCSCTEGQIYCGLTTCPEPGCPAPLPLPDSCCQACKDEASE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 QSDEEDSVQSLHGVRHPQDPCSSDAGRKRGPGTPAPTGLSAPLSFIPRHFRPKGAGSTTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSDEEDSVQSLHGVRHPQDPCSSDAGRKRGPGTPAPTGLSAPLSFIPRHFRPKGAGSTTV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 KIVLKEKHKKACVHGGKTYSHGEVWHPAFRAFGPLPCILCTCEDGRQDCQRVTCPTEYPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KIVLKEKHKKACVHGGKTYSHGEVWHPAFRAFGPLPCILCTCEDGRQDCQRVTCPTEYPC 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 RHPEKVAGKCCKICPEDKADPGHSEISSTRCPKAPGRVLVHTSVSPSPDNLRRFALEHEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RHPEKVAGKCCKICPEDKADPGHSEISSTRCPKAPGRVLVHTSVSPSPDNLRRFALEHEA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 SDLVEIYLWKLVKDEETEAQRGEVPGPRPHSQNLPLDSDQESQEARLPERGTALPTARWP ::::::::::::: NP_001 SDLVEIYLWKLVKGIFHLTQIKKVRKQDFQKEAQHFRLLAGPHEGHWNVFLAQTLELKVT 370 380 390 400 410 420 >>NP_001291346 (OMIM: 613127) chordin-like protein 2 iso (386 aa) initn: 2590 init1: 2590 opt: 2600 Z-score: 2120.1 bits: 401.3 E(85289): 2.4e-111 Smith-Waterman score: 2600; 98.9% identity (99.4% similar) in 361 aa overlap (92-451:26-386) 70 80 90 100 110 120 pF1KB7 TCSEGAHVSCYRLHCPPVHCPQPVTEPQQCCPK-CVEPHTPSGLRAPPKSCQHNGTMYQH ::. .:::::::::::::::::::::::: NP_001 MQNHQKSGLVNFSKDSHETSFSSSSCPSPTAEPHTPSGLRAPPKSCQHNGTMYQH 10 20 30 40 50 130 140 150 160 170 180 pF1KB7 GEIFSAHELFPSRLPNQCVLCSCTEGQIYCGLTTCPEPGCPAPLPLPDSCCQACKDEASE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GEIFSAHELFPSRLPNQCVLCSCTEGQIYCGLTTCPEPGCPAPLPLPDSCCQACKDEASE 60 70 80 90 100 110 190 200 210 220 230 240 pF1KB7 QSDEEDSVQSLHGVRHPQDPCSSDAGRKRGPGTPAPTGLSAPLSFIPRHFRPKGAGSTTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSDEEDSVQSLHGVRHPQDPCSSDAGRKRGPGTPAPTGLSAPLSFIPRHFRPKGAGSTTV 120 130 140 150 160 170 250 260 270 280 290 300 pF1KB7 KIVLKEKHKKACVHGGKTYSHGEVWHPAFRAFGPLPCILCTCEDGRQDCQRVTCPTEYPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KIVLKEKHKKACVHGGKTYSHGEVWHPAFRAFGPLPCILCTCEDGRQDCQRVTCPTEYPC 180 190 200 210 220 230 310 320 330 340 350 360 pF1KB7 RHPEKVAGKCCKICPEDKADPGHSEISSTRCPKAPGRVLVHTSVSPSPDNLRRFALEHEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RHPEKVAGKCCKICPEDKADPGHSEISSTRCPKAPGRVLVHTSVSPSPDNLRRFALEHEA 240 250 260 270 280 290 370 380 390 400 410 420 pF1KB7 SDLVEIYLWKLVKDEETEAQRGEVPGPRPHSQNLPLDSDQESQEARLPERGTALPTARWP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDLVEIYLWKLVKDEETEAQRGEVPGPRPHSQNLPLDSDQESQEARLPERGTALPTARWP 300 310 320 330 340 350 430 440 450 pF1KB7 PRRSLERLPSPDPGAEGHGQSRQSDQDITKT ::::::::::::::::::::::::::::::: NP_001 PRRSLERLPSPDPGAEGHGQSRQSDQDITKT 360 370 380 >>NP_001291345 (OMIM: 613127) chordin-like protein 2 iso (313 aa) initn: 1893 init1: 1893 opt: 1893 Z-score: 1548.0 bits: 295.1 E(85289): 1.7e-79 Smith-Waterman score: 1893; 100.0% identity (100.0% similar) in 257 aa overlap (117-373:1-257) 90 100 110 120 130 140 pF1KB7 EPQQCCPKCVEPHTPSGLRAPPKSCQHNGTMYQHGEIFSAHELFPSRLPNQCVLCSCTEG :::::::::::::::::::::::::::::: NP_001 MYQHGEIFSAHELFPSRLPNQCVLCSCTEG 10 20 30 150 160 170 180 190 200 pF1KB7 QIYCGLTTCPEPGCPAPLPLPDSCCQACKDEASEQSDEEDSVQSLHGVRHPQDPCSSDAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QIYCGLTTCPEPGCPAPLPLPDSCCQACKDEASEQSDEEDSVQSLHGVRHPQDPCSSDAG 40 50 60 70 80 90 210 220 230 240 250 260 pF1KB7 RKRGPGTPAPTGLSAPLSFIPRHFRPKGAGSTTVKIVLKEKHKKACVHGGKTYSHGEVWH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RKRGPGTPAPTGLSAPLSFIPRHFRPKGAGSTTVKIVLKEKHKKACVHGGKTYSHGEVWH 100 110 120 130 140 150 270 280 290 300 310 320 pF1KB7 PAFRAFGPLPCILCTCEDGRQDCQRVTCPTEYPCRHPEKVAGKCCKICPEDKADPGHSEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PAFRAFGPLPCILCTCEDGRQDCQRVTCPTEYPCRHPEKVAGKCCKICPEDKADPGHSEI 160 170 180 190 200 210 330 340 350 360 370 380 pF1KB7 SSTRCPKAPGRVLVHTSVSPSPDNLRRFALEHEASDLVEIYLWKLVKDEETEAQRGEVPG ::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSTRCPKAPGRVLVHTSVSPSPDNLRRFALEHEASDLVEIYLWKLVKGIFHLTQIKKVRK 220 230 240 250 260 270 390 400 410 420 430 440 pF1KB7 PRPHSQNLPLDSDQESQEARLPERGTALPTARWPPRRSLERLPSPDPGAEGHGQSRQSDQ NP_001 QDFQKEAQHFRLLAGPHEGHWNVFLAQTLELKVTASPDKVTKT 280 290 300 310 >>NP_001291344 (OMIM: 613127) chordin-like protein 2 iso (344 aa) initn: 2067 init1: 1690 opt: 1690 Z-score: 1382.9 bits: 264.7 E(85289): 2.7e-70 Smith-Waterman score: 1941; 81.2% identity (81.2% similar) in 345 aa overlap (29-373:9-288) 10 20 30 40 50 60 pF1KB7 MVPEVRVLSSLLGLALLWFPLDSHARARPDMFCLFHGKRYSPGESWHPYLEPQGLMYCLR :::::::::::::::::::::::::::::::: NP_001 MALVGLPGPDMFCLFHGKRYSPGESWHPYLEPQGLMYCLR 10 20 30 40 70 80 90 100 110 120 pF1KB7 CTCSEGAHVSCYRLHCPPVHCPQPVTEPQQCCPKCVEPHTPSGLRAPPKSCQHNGTMYQH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CTCSEGAHVSCYRLHCPPVHCPQPVTEPQQCCPKCVEPHTPSGLRAPPKSCQHNGTMYQH 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB7 GEIFSAHELFPSRLPNQCVLCSCTEGQIYCGLTTCPEPGCPAPLPLPDSCCQACKDEASE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GEIFSAHELFPSRLPNQCVLCSCTEGQIYCGLTTCPEPGCPAPLPLPDSCCQACKDEASE 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB7 QSDEEDSVQSLHGVRHPQDPCSSDAGRKRGPGTPAPTGLSAPLSFIPRHFRPKGAGSTTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSDEEDSVQSLHGVRHPQDPCSSDAGRKRGPGTPAPTGLSAPLSFIPRHFRPKGAGSTTV 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB7 KIVLKEKHKKACVHGGKTYSHGEVWHPAFRAFGPLPCILCTCEDGRQDCQRVTCPTEYPC :::::::::: NP_001 KIVLKEKHKK-------------------------------------------------- 230 310 320 330 340 350 360 pF1KB7 RHPEKVAGKCCKICPEDKADPGHSEISSTRCPKAPGRVLVHTSVSPSPDNLRRFALEHEA ::::::::::::::::::::::::::::::::::::::::::::: NP_001 ---------------EDKADPGHSEISSTRCPKAPGRVLVHTSVSPSPDNLRRFALEHEA 240 250 260 270 370 380 390 400 410 420 pF1KB7 SDLVEIYLWKLVKDEETEAQRGEVPGPRPHSQNLPLDSDQESQEARLPERGTALPTARWP ::::::::::::: NP_001 SDLVEIYLWKLVKGIFHLTQIKKVRKQDFQKEAQHFRLLAGPHEGHWNVFLAQTLELKVT 280 290 300 310 320 330 >>NP_001291320 (OMIM: 613127) chordin-like protein 2 iso (366 aa) initn: 2612 init1: 1690 opt: 1690 Z-score: 1382.5 bits: 264.7 E(85289): 2.9e-70 Smith-Waterman score: 2486; 84.6% identity (84.6% similar) in 423 aa overlap (29-451:9-366) 10 20 30 40 50 60 pF1KB7 MVPEVRVLSSLLGLALLWFPLDSHARARPDMFCLFHGKRYSPGESWHPYLEPQGLMYCLR :::::::::::::::::::::::::::::::: NP_001 MALVGLPGPDMFCLFHGKRYSPGESWHPYLEPQGLMYCLR 10 20 30 40 70 80 90 100 110 120 pF1KB7 CTCSEGAHVSCYRLHCPPVHCPQPVTEPQQCCPKCVEPHTPSGLRAPPKSCQHNGTMYQH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CTCSEGAHVSCYRLHCPPVHCPQPVTEPQQCCPKCVEPHTPSGLRAPPKSCQHNGTMYQH 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB7 GEIFSAHELFPSRLPNQCVLCSCTEGQIYCGLTTCPEPGCPAPLPLPDSCCQACKDEASE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GEIFSAHELFPSRLPNQCVLCSCTEGQIYCGLTTCPEPGCPAPLPLPDSCCQACKDEASE 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB7 QSDEEDSVQSLHGVRHPQDPCSSDAGRKRGPGTPAPTGLSAPLSFIPRHFRPKGAGSTTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSDEEDSVQSLHGVRHPQDPCSSDAGRKRGPGTPAPTGLSAPLSFIPRHFRPKGAGSTTV 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB7 KIVLKEKHKKACVHGGKTYSHGEVWHPAFRAFGPLPCILCTCEDGRQDCQRVTCPTEYPC :::::::::: NP_001 KIVLKEKHKK-------------------------------------------------- 230 310 320 330 340 350 360 pF1KB7 RHPEKVAGKCCKICPEDKADPGHSEISSTRCPKAPGRVLVHTSVSPSPDNLRRFALEHEA ::::::::::::::::::::::::::::::::::::::::::::: NP_001 ---------------EDKADPGHSEISSTRCPKAPGRVLVHTSVSPSPDNLRRFALEHEA 240 250 260 270 370 380 390 400 410 420 pF1KB7 SDLVEIYLWKLVKDEETEAQRGEVPGPRPHSQNLPLDSDQESQEARLPERGTALPTARWP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDLVEIYLWKLVKDEETEAQRGEVPGPRPHSQNLPLDSDQESQEARLPERGTALPTARWP 280 290 300 310 320 330 430 440 450 pF1KB7 PRRSLERLPSPDPGAEGHGQSRQSDQDITKT ::::::::::::::::::::::::::::::: NP_001 PRRSLERLPSPDPGAEGHGQSRQSDQDITKT 340 350 360 >>NP_660277 (OMIM: 300350) chordin-like protein 1 isofor (456 aa) initn: 1003 init1: 626 opt: 1107 Z-score: 908.6 bits: 177.3 E(85289): 7.2e-44 Smith-Waterman score: 1107; 42.6% identity (68.3% similar) in 357 aa overlap (30-373:34-383) 10 20 30 40 50 pF1KB7 MVPEVRVLSSLLGLALLWFPLDSHARARPDMFCLFHGKRYSPGESWHPYLEPQGLMYCL . .:.:. :.: :: ::::::: ::.::. NP_660 KWKMGGMKYIFSLLFFLLLEGGKTEQVKHSETYCMFQDKKYRVGERWHPYLEPYGLVYCV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 RCTCSEGAHVSCYRLHCPPVHCPQPVTEPQQCCPKCVEPHTPSGLRAPPKSCQHNGTMYQ : :::...: : :..:: ::: .:: :. :::.: . : . .. :::..::: :: NP_660 NCICSENGNVLCSRVRCPNVHCLSPVHIPHLCCPRCPDSLPPVNNKVTSKSCEYNGTTYQ 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 HGEIFSAHELFPSRLPNQCVLCSCTEGQIYCGLTTCPEPGCPAPLPLPDSCCQACKDEAS :::.: :. :: .: ::::. :::.::..:::: :::. : :. .:::::..:. .. NP_660 HGELFVAEGLFQNRQPNQCTQCSCSEGNVYCGLKTCPKLTCAFPVSVPDSCCRVCRGDGE 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 EQSDEEDSVQSLHGVRHPQDPCSSDAGRKRGPGTPAPTGLSAPLSFIP--RHFR-----P . .. :. :.: . . . .:. : :. .. :: .: : : NP_660 LSWEHSDG----DIFRQPANREARHS-YHRSHYDPPPSRQAGGLSRFPGARSHRGALMDS 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 KGAGSTTVKIVLKEKHK--KACVHGGKTYSHGEVWHPAFRAFGPLPCILCTCEDGRQDCQ . :..: :.::...::: ..:: .:::::::: ::: .:::: . :.::::. .:.:. NP_660 QQASGTIVQIVINNKHKHGQVCVSNGKTYSHGESWHPNLRAFGIVECVLCTCNVTKQECK 240 250 260 270 280 290 300 310 320 330 340 pF1KB7 RVTCPTEYPCRHPEKVAGKCCKICPEDKAD--PGHS-EISSTRCPKAPGRVLVHTSV-SP .. ::..:::..:.:. :::::.:: :: ::.: . .. : . . :. :: NP_660 KIHCPNRYPCKYPQKIDGKCCKVCPGKKAKELPGQSFDNKGYFCGEET--MPVYESVFME 300 310 320 330 340 350 350 360 370 380 390 400 pF1KB7 SPDNLRRFALEHEASDLVEIYLWKLVKDEETEAQRGEVPGPRPHSQNLPLDSDQESQEAR . .. :..::: : ::...: . : NP_660 DGETTRKIALETERPPQVEVHVWTIRKGILQHFHIEKISKRMFEELPHFKLVTRTTLSQW 360 370 380 390 400 410 >>XP_005262281 (OMIM: 300350) PREDICTED: chordin-like pr (452 aa) initn: 1047 init1: 669 opt: 1106 Z-score: 907.8 bits: 177.2 E(85289): 7.9e-44 Smith-Waterman score: 1106; 42.5% identity (68.7% similar) in 355 aa overlap (30-373:34-379) 10 20 30 40 50 pF1KB7 MVPEVRVLSSLLGLALLWFPLDSHARARPDMFCLFHGKRYSPGESWHPYLEPQGLMYCL . .:.:. :.: :: ::::::: ::.::. XP_005 KWKMGGMKYIFSLLFFLLLEGGKTEQVKHSETYCMFQDKKYRVGERWHPYLEPYGLVYCV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 RCTCSEGAHVSCYRLHCPPVHCPQPVTEPQQCCPKCVEPHTPSGLRAPPKSCQHNGTMYQ : :::...: : :..:: ::: .:: :. :::.: . : . .. :::..::: :: XP_005 NCICSENGNVLCSRVRCPNVHCLSPVHIPHLCCPRCPDSLPPVNNKVTSKSCEYNGTTYQ 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 HGEIFSAHELFPSRLPNQCVLCSCTEGQIYCGLTTCPEPGCPAPLPLPDSCCQACKDEAS :::.: :. :: .: ::::. :::.::..:::: :::. : :. .:::::..:. .. XP_005 HGELFVAEGLFQNRQPNQCTQCSCSEGNVYCGLKTCPKLTCAFPVSVPDSCCRVCRGDGE 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 EQSDEEDSVQSLHGVRHPQDPCSSDAGRKRGPGTPAPTGLSAPLSFIP--RHFR-----P . .. :. :.: . . . .:. : :. .. :: .: : : XP_005 LSWEHSDG----DIFRQPANREARHS-YHRSHYDPPPSRQAGGLSRFPGARSHRGALMDS 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 KGAGSTTVKIVLKEKHK--KACVHGGKTYSHGEVWHPAFRAFGPLPCILCTCEDGRQDCQ . :..: :.::...::: ..:: .:::::::: ::: .:::: . :.::::. .:.:. XP_005 QQASGTIVQIVINNKHKHGQVCVSNGKTYSHGESWHPNLRAFGIVECVLCTCNVTKQECK 240 250 260 270 280 290 300 310 320 330 340 pF1KB7 RVTCPTEYPCRHPEKVAGKCCKICPEDKADPGHS-EISSTRCPKAPGRVLVHTSV-SPSP .. ::..:::..:.:. :::::.:::. ::.: . .. : . . :. :: . XP_005 KIHCPNRYPCKYPQKIDGKCCKVCPEEL--PGQSFDNKGYFCGEET--MPVYESVFMEDG 300 310 320 330 340 350 350 360 370 380 390 400 pF1KB7 DNLRRFALEHEASDLVEIYLWKLVKDEETEAQRGEVPGPRPHSQNLPLDSDQESQEARLP .. :..::: : ::...: . : XP_005 ETTRKIALETERPPQVEVHVWTIRKGILQHFHIEKISKRMFEELPHFKLVTRTTLSQWKI 360 370 380 390 400 410 >>NP_001137454 (OMIM: 300350) chordin-like protein 1 iso (457 aa) initn: 1003 init1: 626 opt: 1105 Z-score: 907.0 bits: 177.1 E(85289): 8.9e-44 Smith-Waterman score: 1105; 42.5% identity (68.2% similar) in 358 aa overlap (30-373:34-384) 10 20 30 40 50 pF1KB7 MVPEVRVLSSLLGLALLWFPLDSHARARPDMFCLFHGKRYSPGESWHPYLEPQGLMYCL . .:.:. :.: :: ::::::: ::.::. NP_001 KWKMGGMKYIFSLLFFLLLEGGKTEQVKHSETYCMFQDKKYRVGERWHPYLEPYGLVYCV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB7 RCTCSEGAHVSCYRLHCPPVHCPQPVTEPQQCCPKCVEPHTPSGLRAPPKSCQHNGTMYQ : :::...: : :..:: ::: .:: :. :::.: . : . .. :::..::: :: NP_001 NCICSENGNVLCSRVRCPNVHCLSPVHIPHLCCPRCPDSLPPVNNKVTSKSCEYNGTTYQ 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB7 HGEIFSAHELFPSRLPNQCVLCSCTEGQIYCGLTTCPEPGCPAPLPLPDSCCQACKDEAS :::.: :. :: .: ::::. :::.::..:::: :::. : :. .:::::..:. .. NP_001 HGELFVAEGLFQNRQPNQCTQCSCSEGNVYCGLKTCPKLTCAFPVSVPDSCCRVCRGDGE 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB7 EQSDEEDSVQSLHGVRHPQDPCSSDAGRKRGPGTPAPTGLSAPLSFIP--RHFR-----P . .. :. :.: . . . .:. : :. .. :: .: : : NP_001 LSWEHSDG----DIFRQPANREARHS-YHRSHYDPPPSRQAGGLSRFPGARSHRGALMDS 190 200 210 220 230 240 250 260 270 280 290 pF1KB7 KGAGSTTVKIVLKEKHK--KACVHGGKTYSHGEVWHPAFRAFGPLPCILCTCEDGRQDCQ . :..: :.::...::: ..:: .:::::::: ::: .:::: . :.::::. .:.:. NP_001 QQASGTIVQIVINNKHKHGQVCVSNGKTYSHGESWHPNLRAFGIVECVLCTCNVTKQECK 240 250 260 270 280 290 300 310 320 330 340 pF1KB7 RVTCPTEYPCRHPEKVAGKCCKICPEDKAD---PGHS-EISSTRCPKAPGRVLVHTSV-S .. ::..:::..:.:. :::::.:: :: ::.: . .. : . . :. :: NP_001 KIHCPNRYPCKYPQKIDGKCCKVCPGKKAKEELPGQSFDNKGYFCGEET--MPVYESVFM 300 310 320 330 340 350 350 360 370 380 390 400 pF1KB7 PSPDNLRRFALEHEASDLVEIYLWKLVKDEETEAQRGEVPGPRPHSQNLPLDSDQESQEA . .. :..::: : ::...: . : NP_001 EDGETTRKIALETERPPQVEVHVWTIRKGILQHFHIEKISKRMFEELPHFKLVTRTTLSQ 360 370 380 390 400 410 451 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 06:26:41 2016 done: Fri Nov 4 06:26:43 2016 Total Scan time: 10.830 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]