Result of FASTA (omim) for
pF1KB7302
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7302, 1251 aa
1>>>pF1KB7302 1251 - 1251 aa - 1251 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 12.5413+/-0.000418; mu= -8.1925+/- 0.026
mean_var=414.6613+/-83.978, 0's: 0 Z-trim(123.9): 69 B-trim: 717 in 1/57
Lambda= 0.062984
statistics sampled from 44465 (44538) to 44465 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.785), E-opt: 0.2 (0.522), width: 16
Scan time: 19.250
The best scores are: opt bits E(85289)
NP_001288 (OMIM: 600724,613767) cyclic nucleotide- (1251) 8433 781.2 0
NP_001273059 (OMIM: 600724,613767) cyclic nucleoti (1245) 8370 775.5 0
XP_011521172 (OMIM: 600724,613767) PREDICTED: cycl ( 868) 5377 503.4 2.6e-141
NP_061971 (OMIM: 248200,262300,605080) cyclic nucl ( 809) 2415 234.3 2.6e-60
XP_011515440 (OMIM: 248200,262300,605080) PREDICTE ( 671) 2377 230.8 2.4e-59
NP_001129111 (OMIM: 600724,613767) cyclic nucleoti ( 299) 1998 196.1 3e-49
XP_006712306 (OMIM: 216900,600053) PREDICTED: cycl ( 731) 966 102.6 1e-20
NP_001073347 (OMIM: 216900,600053) cyclic nucleoti ( 676) 960 102.0 1.4e-20
NP_001289 (OMIM: 216900,600053) cyclic nucleotide- ( 694) 944 100.6 4e-20
XP_011508856 (OMIM: 216900,600053) PREDICTED: cycl ( 749) 944 100.6 4.2e-20
XP_011511925 (OMIM: 123825,268000,613756) PREDICTE ( 690) 922 98.6 1.6e-19
NP_000078 (OMIM: 123825,268000,613756) cGMP-gated ( 690) 922 98.6 1.6e-19
XP_016863201 (OMIM: 123825,268000,613756) PREDICTE ( 690) 922 98.6 1.6e-19
NP_001136036 (OMIM: 123825,268000,613756) cGMP-gat ( 759) 922 98.6 1.7e-19
XP_005248106 (OMIM: 123825,268000,613756) PREDICTE ( 765) 922 98.6 1.7e-19
NP_005131 (OMIM: 300338) cyclic nucleotide-gated o ( 664) 881 94.8 2e-18
NP_001032406 (OMIM: 609472) cyclic nucleotide-gate ( 575) 836 90.7 3.1e-17
XP_016872706 (OMIM: 609472) PREDICTED: cyclic nucl ( 577) 827 89.9 5.4e-17
XP_016872707 (OMIM: 609472) PREDICTED: cyclic nucl ( 537) 799 87.3 3e-16
XP_016872708 (OMIM: 609472) PREDICTED: cyclic nucl ( 537) 799 87.3 3e-16
NP_001185 (OMIM: 602781) potassium/sodium hyperpol ( 889) 515 61.7 2.6e-08
NP_005468 (OMIM: 163800,605206,613123) potassium/s (1203) 482 58.8 2.6e-07
NP_066550 (OMIM: 602780,615871) potassium/sodium h ( 890) 467 57.3 5.4e-07
XP_011508118 (OMIM: 609973) PREDICTED: potassium/s ( 727) 453 56.0 1.1e-06
XP_011519450 (OMIM: 163800,605206,613123) PREDICTE ( 797) 454 56.1 1.1e-06
NP_065948 (OMIM: 609973) potassium/sodium hyperpol ( 774) 453 56.0 1.2e-06
XP_016857407 (OMIM: 609973) PREDICTED: potassium/s ( 535) 425 53.3 5.1e-06
XP_011508120 (OMIM: 609973) PREDICTED: potassium/s ( 535) 425 53.3 5.1e-06
XP_011508119 (OMIM: 609973) PREDICTED: potassium/s ( 720) 414 52.4 1.3e-05
NP_742054 (OMIM: 152427,609620,613688) potassium v ( 819) 344 46.1 0.0012
XP_011514487 (OMIM: 152427,609620,613688) PREDICTE (1059) 344 46.2 0.0014
XP_016867685 (OMIM: 152427,609620,613688) PREDICTE (1100) 344 46.2 0.0015
XP_016867684 (OMIM: 152427,609620,613688) PREDICTE (1109) 344 46.2 0.0015
NP_000229 (OMIM: 152427,609620,613688) potassium v (1159) 344 46.2 0.0015
XP_016874586 (OMIM: 604527) PREDICTED: potassium v ( 720) 325 44.3 0.0035
XP_016874585 (OMIM: 604527) PREDICTED: potassium v (1016) 326 44.5 0.0043
XP_011536388 (OMIM: 604527) PREDICTED: potassium v (1034) 326 44.5 0.0043
XP_011536387 (OMIM: 604527) PREDICTED: potassium v (1094) 326 44.5 0.0045
NP_001300959 (OMIM: 604527) potassium voltage-gate (1023) 325 44.4 0.0046
NP_036416 (OMIM: 604527) potassium voltage-gated c (1083) 325 44.5 0.0048
>>NP_001288 (OMIM: 600724,613767) cyclic nucleotide-gate (1251 aa)
initn: 8433 init1: 8433 opt: 8433 Z-score: 4156.5 bits: 781.2 E(85289): 0
Smith-Waterman score: 8433; 100.0% identity (100.0% similar) in 1251 aa overlap (1-1251:1-1251)
10 20 30 40 50 60
pF1KB7 MLGWVQRVLPQPPGTPRKTKMQEEEEVEPEPEMEAEVEPEPNPEEAETESESMPPEESFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLGWVQRVLPQPPGTPRKTKMQEEEEVEPEPEMEAEVEPEPNPEEAETESESMPPEESFK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 EEEVAVADPSPQETKEAALTSTISLRAQGAEISEMNSPSRRVLTWLMKGVEKVIPQPVHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEEVAVADPSPQETKEAALTSTISLRAQGAEISEMNSPSRRVLTWLMKGVEKVIPQPVHS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 ITEDPAQILGHGSTGDTGCTDEPNEALEAQDTRPGLRLLLWLEQNLERVLPQPPKSSEVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITEDPAQILGHGSTGDTGCTDEPNEALEAQDTRPGLRLLLWLEQNLERVLPQPPKSSEVW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 RDEPAVATGAASDPAPPGRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPAPEPQPGSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDEPAVATGAASDPAPPGRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPAPEPQPGSQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 AQTSSLPPTRDPARLVAWVLHRLEMALPQPVLHGKIGEQEPDSPGICDVQTISILPGGQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQTSSLPPTRDPARLVAWVLHRLEMALPQPVLHGKIGEQEPDSPGICDVQTISILPGGQV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 EPDLVLEEVEPPWEDAHQDVSTSPQGTEVVPAYEEENKAVEKMPRELSRIEEEKEDEEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EPDLVLEEVEPPWEDAHQDVSTSPQGTEVVPAYEEENKAVEKMPRELSRIEEEKEDEEEE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 EEEEEEEEEEEVTEVLLDSCVVSQVGVGQSEEDGTRPQSTSDQKLWEEVGEEAKKEAEEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEEEEEEEEEEVTEVLLDSCVVSQVGVGQSEEDGTRPQSTSDQKLWEEVGEEAKKEAEEK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB7 AKEEAEEVAEEEAEKEPQDWAETKEEPEAEAEAASSGVPATKQHPEVQVEDTDADSCPLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AKEEAEEVAEEEAEKEPQDWAETKEEPEAEAEAASSGVPATKQHPEVQVEDTDADSCPLM
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB7 AEENPPSTVLPPPSPAKSDTLIVPSSASGTHRKKLPSEDDEAEELKALSPAESPVVAWSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEENPPSTVLPPPSPAKSDTLIVPSSASGTHRKKLPSEDDEAEELKALSPAESPVVAWSD
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB7 PTTPKDTDGQDRAASTASTNSAIINDRLQELVKLFKERTEKVKEKLIDPDVTSDEESPKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTTPKDTDGQDRAASTASTNSAIINDRLQELVKLFKERTEKVKEKLIDPDVTSDEESPKP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB7 SPAKKAPEPAPDTKPAEAEPVEEEHYCDMLCCKFKHRPWKKYQFPQSIDPLTNLMYVLWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPAKKAPEPAPDTKPAEAEPVEEEHYCDMLCCKFKHRPWKKYQFPQSIDPLTNLMYVLWL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB7 FFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVRGGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVRGGD
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB7 IITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVNPLLRLPRCLKYMAFFEFNSRLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVNPLLRLPRCLKYMAFFEFNSRLE
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB7 SILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYDGVGNSYIRCYYFAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYDGVGNSYIRCYYFAV
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB7 KTLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KTLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDST
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB7 VKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKV
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB7 ALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLV
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB7 TLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKA
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB7 RRMLRSNNKPKEEKSVLILPPRAGTPKLFNAALAMTGKMGGKGAKGGKLAHLRARLKELA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRMLRSNNKPKEEKSVLILPPRAGTPKLFNAALAMTGKMGGKGAKGGKLAHLRARLKELA
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KB7 ALEAAAKQQELVEQAKSSQDVKGEEGSAAPDQHTHPKEAATDPPAPRTPPEPPGSPPSSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALEAAAKQQELVEQAKSSQDVKGEEGSAAPDQHTHPKEAATDPPAPRTPPEPPGSPPSSP
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250
pF1KB7 PPASLGRPEGEEEGPAEPEEHSVRICMSPGPEPGEQILSVKMPEEREEKAE
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPASLGRPEGEEEGPAEPEEHSVRICMSPGPEPGEQILSVKMPEEREEKAE
1210 1220 1230 1240 1250
>>NP_001273059 (OMIM: 600724,613767) cyclic nucleotide-g (1245 aa)
initn: 7132 init1: 7132 opt: 8370 Z-score: 4125.5 bits: 775.5 E(85289): 0
Smith-Waterman score: 8370; 99.5% identity (99.5% similar) in 1251 aa overlap (1-1251:1-1245)
10 20 30 40 50 60
pF1KB7 MLGWVQRVLPQPPGTPRKTKMQEEEEVEPEPEMEAEVEPEPNPEEAETESESMPPEESFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLGWVQRVLPQPPGTPRKTKMQEEEEVEPEPEMEAEVEPEPNPEEAETESESMPPEESFK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 EEEVAVADPSPQETKEAALTSTISLRAQGAEISEMNSPSRRVLTWLMKGVEKVIPQPVHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEEVAVADPSPQETKEAALTSTISLRAQGAEISEMNSPSRRVLTWLMKGVEKVIPQPVHS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 ITEDPAQILGHGSTGDTGCTDEPNEALEAQDTRPGLRLLLWLEQNLERVLPQPPKSSEVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITEDPAQILGHGSTGDTGCTDEPNEALEAQDTRPGLRLLLWLEQNLERVLPQPPKSSEVW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 RDEPAVATGAASDPAPPGRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPAPEPQPGSQ
:::::::: ::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDEPAVAT------APPGRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPAPEPQPGSQ
190 200 210 220 230
250 260 270 280 290 300
pF1KB7 AQTSSLPPTRDPARLVAWVLHRLEMALPQPVLHGKIGEQEPDSPGICDVQTISILPGGQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQTSSLPPTRDPARLVAWVLHRLEMALPQPVLHGKIGEQEPDSPGICDVQTISILPGGQV
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB7 EPDLVLEEVEPPWEDAHQDVSTSPQGTEVVPAYEEENKAVEKMPRELSRIEEEKEDEEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EPDLVLEEVEPPWEDAHQDVSTSPQGTEVVPAYEEENKAVEKMPRELSRIEEEKEDEEEE
300 310 320 330 340 350
370 380 390 400 410 420
pF1KB7 EEEEEEEEEEEVTEVLLDSCVVSQVGVGQSEEDGTRPQSTSDQKLWEEVGEEAKKEAEEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEEEEEEEEEEVTEVLLDSCVVSQVGVGQSEEDGTRPQSTSDQKLWEEVGEEAKKEAEEK
360 370 380 390 400 410
430 440 450 460 470 480
pF1KB7 AKEEAEEVAEEEAEKEPQDWAETKEEPEAEAEAASSGVPATKQHPEVQVEDTDADSCPLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AKEEAEEVAEEEAEKEPQDWAETKEEPEAEAEAASSGVPATKQHPEVQVEDTDADSCPLM
420 430 440 450 460 470
490 500 510 520 530 540
pF1KB7 AEENPPSTVLPPPSPAKSDTLIVPSSASGTHRKKLPSEDDEAEELKALSPAESPVVAWSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEENPPSTVLPPPSPAKSDTLIVPSSASGTHRKKLPSEDDEAEELKALSPAESPVVAWSD
480 490 500 510 520 530
550 560 570 580 590 600
pF1KB7 PTTPKDTDGQDRAASTASTNSAIINDRLQELVKLFKERTEKVKEKLIDPDVTSDEESPKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTTPKDTDGQDRAASTASTNSAIINDRLQELVKLFKERTEKVKEKLIDPDVTSDEESPKP
540 550 560 570 580 590
610 620 630 640 650 660
pF1KB7 SPAKKAPEPAPDTKPAEAEPVEEEHYCDMLCCKFKHRPWKKYQFPQSIDPLTNLMYVLWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPAKKAPEPAPDTKPAEAEPVEEEHYCDMLCCKFKHRPWKKYQFPQSIDPLTNLMYVLWL
600 610 620 630 640 650
670 680 690 700 710 720
pF1KB7 FFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVRGGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVRGGD
660 670 680 690 700 710
730 740 750 760 770 780
pF1KB7 IITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVNPLLRLPRCLKYMAFFEFNSRLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVNPLLRLPRCLKYMAFFEFNSRLE
720 730 740 750 760 770
790 800 810 820 830 840
pF1KB7 SILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYDGVGNSYIRCYYFAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYDGVGNSYIRCYYFAV
780 790 800 810 820 830
850 860 870 880 890 900
pF1KB7 KTLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KTLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDST
840 850 860 870 880 890
910 920 930 940 950 960
pF1KB7 VKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKV
900 910 920 930 940 950
970 980 990 1000 1010 1020
pF1KB7 ALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLV
960 970 980 990 1000 1010
1030 1040 1050 1060 1070 1080
pF1KB7 TLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKA
1020 1030 1040 1050 1060 1070
1090 1100 1110 1120 1130 1140
pF1KB7 RRMLRSNNKPKEEKSVLILPPRAGTPKLFNAALAMTGKMGGKGAKGGKLAHLRARLKELA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRMLRSNNKPKEEKSVLILPPRAGTPKLFNAALAMTGKMGGKGAKGGKLAHLRARLKELA
1080 1090 1100 1110 1120 1130
1150 1160 1170 1180 1190 1200
pF1KB7 ALEAAAKQQELVEQAKSSQDVKGEEGSAAPDQHTHPKEAATDPPAPRTPPEPPGSPPSSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALEAAAKQQELVEQAKSSQDVKGEEGSAAPDQHTHPKEAATDPPAPRTPPEPPGSPPSSP
1140 1150 1160 1170 1180 1190
1210 1220 1230 1240 1250
pF1KB7 PPASLGRPEGEEEGPAEPEEHSVRICMSPGPEPGEQILSVKMPEEREEKAE
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPASLGRPEGEEEGPAEPEEHSVRICMSPGPEPGEQILSVKMPEEREEKAE
1200 1210 1220 1230 1240
>>XP_011521172 (OMIM: 600724,613767) PREDICTED: cyclic n (868 aa)
initn: 5377 init1: 5377 opt: 5377 Z-score: 2658.0 bits: 503.4 E(85289): 2.6e-141
Smith-Waterman score: 5377; 100.0% identity (100.0% similar) in 794 aa overlap (458-1251:75-868)
430 440 450 460 470 480
pF1KB7 VAEEEAEKEPQDWAETKEEPEAEAEAASSGVPATKQHPEVQVEDTDADSCPLMAEENPPS
::::::::::::::::::::::::::::::
XP_011 ITRIPVLTSRRTSLSNSSFAKETRSSIRQLVPATKQHPEVQVEDTDADSCPLMAEENPPS
50 60 70 80 90 100
490 500 510 520 530 540
pF1KB7 TVLPPPSPAKSDTLIVPSSASGTHRKKLPSEDDEAEELKALSPAESPVVAWSDPTTPKDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TVLPPPSPAKSDTLIVPSSASGTHRKKLPSEDDEAEELKALSPAESPVVAWSDPTTPKDT
110 120 130 140 150 160
550 560 570 580 590 600
pF1KB7 DGQDRAASTASTNSAIINDRLQELVKLFKERTEKVKEKLIDPDVTSDEESPKPSPAKKAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DGQDRAASTASTNSAIINDRLQELVKLFKERTEKVKEKLIDPDVTSDEESPKPSPAKKAP
170 180 190 200 210 220
610 620 630 640 650 660
pF1KB7 EPAPDTKPAEAEPVEEEHYCDMLCCKFKHRPWKKYQFPQSIDPLTNLMYVLWLFFVVMAW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPAPDTKPAEAEPVEEEHYCDMLCCKFKHRPWKKYQFPQSIDPLTNLMYVLWLFFVVMAW
230 240 250 260 270 280
670 680 690 700 710 720
pF1KB7 NWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVRGGDIITDKKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVRGGDIITDKKD
290 300 310 320 330 340
730 740 750 760 770 780
pF1KB7 MRNNYLKSRRFKMDLLSLLPLDFLYLKVGVNPLLRLPRCLKYMAFFEFNSRLESILSKAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MRNNYLKSRRFKMDLLSLLPLDFLYLKVGVNPLLRLPRCLKYMAFFEFNSRLESILSKAY
350 360 370 380 390 400
790 800 810 820 830 840
pF1KB7 VYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYDGVGNSYIRCYYFAVKTLITIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYDGVGNSYIRCYYFAVKTLITIG
410 420 430 440 450 460
850 860 870 880 890 900
pF1KB7 GLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFY
470 480 490 500 510 520
910 920 930 940 950 960
pF1KB7 KIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCD
530 540 550 560 570 580
970 980 990 1000 1010 1020
pF1KB7 RQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSV
590 600 610 620 630 640
1030 1040 1050 1060 1070 1080
pF1KB7 FGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKARRMLRSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKARRMLRSN
650 660 670 680 690 700
1090 1100 1110 1120 1130 1140
pF1KB7 NKPKEEKSVLILPPRAGTPKLFNAALAMTGKMGGKGAKGGKLAHLRARLKELAALEAAAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NKPKEEKSVLILPPRAGTPKLFNAALAMTGKMGGKGAKGGKLAHLRARLKELAALEAAAK
710 720 730 740 750 760
1150 1160 1170 1180 1190 1200
pF1KB7 QQELVEQAKSSQDVKGEEGSAAPDQHTHPKEAATDPPAPRTPPEPPGSPPSSPPPASLGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQELVEQAKSSQDVKGEEGSAAPDQHTHPKEAATDPPAPRTPPEPPGSPPSSPPPASLGR
770 780 790 800 810 820
1210 1220 1230 1240 1250
pF1KB7 PEGEEEGPAEPEEHSVRICMSPGPEPGEQILSVKMPEEREEKAE
::::::::::::::::::::::::::::::::::::::::::::
XP_011 PEGEEEGPAEPEEHSVRICMSPGPEPGEQILSVKMPEEREEKAE
830 840 850 860
>>NP_061971 (OMIM: 248200,262300,605080) cyclic nucleoti (809 aa)
initn: 2219 init1: 2136 opt: 2415 Z-score: 1203.8 bits: 234.3 E(85289): 2.6e-60
Smith-Waterman score: 2428; 46.2% identity (72.2% similar) in 853 aa overlap (409-1248:14-809)
380 390 400 410 420 430
pF1KB7 SCVVSQVGVGQSEEDGTRPQSTSDQKLWEEVGEEAKKEAEEKAKEEAEEVAEEEAEKEPQ
.::. ..: . .::. . ... . :
NP_061 MFKSLTKVNKVKPIGENNENEQSSRRNEEGSHPSNQSQQTTAQ
10 20 30 40
440 450 460 470 480 490
pF1KB7 DWAETKEEPEAEAEAASSGVPATKQHPEVQVEDTDADSCPLMAEENPPSTVLPPPSPAKS
. :.: : : ....:.:...:.....: ....: . . :.: ..
NP_061 E--ENKGE---EKSLKTKSTPVTSEEPHTNIQDK-------LSKKNSSGDLTTNPDPQNA
50 60 70 80 90
500 510 520 530 540 550
pF1KB7 DTLIVPSSASGTHRKKLPSEDDEAEELKALSPAESPVVAWSDPTTPKDTDGQDRAASTAS
. .:: .: : : ..:.. :..: :.. ..
NP_061 ------AEPTGT----VP-------EQKEMDPGKE------GPNSP-----QNKPPAAPV
100 110 120
560 570 580 590 600 610
pF1KB7 TNSAIINDRLQELVKLFKERTEKVKEKLIDPDVTSDEESPKPSPAKKAPEPAPDTKPAEA
: . .:..::: ...:: :.::.. :..: :. :: : .: .: ..
NP_061 INE-YADAQLHNLVKRMRQRTALYKKKLVEGDLSS----PEASPQTAKPTAVPPVKESDD
130 140 150 160 170
620 630 640 650 660 670
pF1KB7 EPVEEEHYCDMLCCKFKHRPWKKY----QFPQSIDPLTNLMYVLWLFFVVMAWNWNCWLI
.:.: :: .: : :. : .: ..:.::: :. .:.:::..:..:.:::: .:
NP_061 KPTE--HYYRLLWFKVKKMPLTEYLKRIKLPNSIDSYTDRLYLLWLLLVTLAYNWNCCFI
180 190 200 210 220 230
680 690 700 710 720 730
pF1KB7 PVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVRGGDIITDKKDMRNNYLK
:.: .::::: ::::.::. : .::.::. :. .: :::::::::::.:....:..:
NP_061 PLRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQPRLQFVRGGDIIVDSNELRKHYRT
240 250 260 270 280 290
740 750 760 770 780 790
pF1KB7 SRRFKMDLLSLLPLDFLYLKVGVNPLLRLPRCLKYMAFFEFNSRLESILSKAYVYRVIRT
: .:..:. :..:.:. :: : ::..: : ::: .::::: .::::..:::.::::::
NP_061 STKFQLDVASIIPFDICYLFFGFNPMFRANRMLKYTSFFEFNHHLESIMDKAYIYRVIRT
300 310 320 330 340 350
800 810 820 830 840 850
pF1KB7 TAYLLYSLHLNSCLYYWASAYQGLGSTHWVYDGVGNSYIRCYYFAVKTLITIGGLPDPKT
:.:::. ::.:.:.::::: :.:.:.:.::::: :: :.::::.::.:::::::::.:.:
NP_061 TGYLLFILHINACVYYWASNYEGIGTTRWVYDGEGNEYLRCYYWAVRTLITIGGLPEPQT
360 370 380 390 400 410
860 870 880 890 900 910
pF1KB7 LFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQ
::::::::::.:.:::.:: .:::::::.:::::.:.:.:.:::.:. ::: :.::: ::
NP_061 LFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLVQ
420 430 440 450 460 470
920 930 940 950 960 970
pF1KB7 NRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDM
.::.::::::: :: :::::.:. :: ..: ::::::..:.::: ::.::: :::.::
NP_061 KRVRTWYEYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYDM
480 490 500 510 520 530
980 990 1000 1010 1020 1030
pF1KB7 LKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVFGEISLL
: ::.::.:::.:.::::::::.:::::. :.::::::::: .:::::::::::::::::
NP_061 LLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGTKVLVTLKAGSVFGEISLL
540 550 560 570 580 590
1040 1050 1060 1070 1080
pF1KB7 AVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKARRMLRSNNK-----
:.:::::::::::::::.::. :::: :.:::::::.:...: :::: .:... :
NP_061 AAGGGNRRTANVVAHGFANLLTLDKKTLQEILVHYPDSERILMKKARVLLKQKAKTAEAT
600 610 620 630 640 650
1090 1100 1110 1120 1130 1140
pF1KB7 PKEEKSVLILPPRAGTPKLFNAALAMTGKMGGKGAKGGKLAHLRARLKELAALEAAAKQQ
: .. .:..::. :::::.. :. ::: ..::.: .::. : . ...
NP_061 PPRKDLALLFPPKEETPKLFKTLLGGTGK--------ASLARL-LKLKREQAAQKKENSE
660 670 680 690 700
1150 1160 1170 1180 1190 1200
pF1KB7 ELVEQAKSSQDVKGEEGSAAPDQHTHPKEAATDPPAPRTPPEPPGSPP--SSPPPASLGR
:..: ..: . :. . ... . :: : : : : : . : .. : : .
NP_061 GGEEEGKENEDKQKENEDKQKENEDKGKENE-DKDKGREPEEKPLDRPECTASPIAVEEE
710 720 730 740 750 760
1210 1220 1230 1240 1250
pF1KB7 PEGEEEG--PAEPEEHSVRICMSPGPEPGEQILSVKMPEEREEKAE
:.. .. : ..:. : :.:. : ::..:.... :. ..
NP_061 PHSVRRTVLPRGTSRQSLIISMAPSAEGGEEVLTIEVKEKAKQ
770 780 790 800
>>XP_011515440 (OMIM: 248200,262300,605080) PREDICTED: c (671 aa)
initn: 2136 init1: 2136 opt: 2377 Z-score: 1186.3 bits: 230.8 E(85289): 2.4e-59
Smith-Waterman score: 2377; 52.9% identity (77.4% similar) in 686 aa overlap (576-1248:2-671)
550 560 570 580 590 600
pF1KB7 DTDGQDRAASTASTNSAIINDRLQELVKLFKERTEKVKEKLIDPDVTSDEESPKPSPAKK
..:: :.::.. :.. ::. ::
XP_011 MRQRTALYKKKLVEGDLS----SPEASPQTA
10 20
610 620 630 640 650 660
pF1KB7 APEPAPDTKPAEAEPVEEEHYCDMLCCKFKHRPWKKY----QFPQSIDPLTNLMYVLWLF
: .: .: .. .:.: :: .: : :. : .: ..:.::: :. .:.:::.
XP_011 KPTAVPPVKESDDKPTE--HYYRLLWFKVKKMPLTEYLKRIKLPNSIDSYTDRLYLLWLL
30 40 50 60 70 80
670 680 690 700 710 720
pF1KB7 FVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVRGGDI
.:..:.:::: .::.: .::::: ::::.::. : .::.::. :. .: ::::::::::
XP_011 LVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQPRLQFVRGGDI
90 100 110 120 130 140
730 740 750 760 770 780
pF1KB7 ITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVNPLLRLPRCLKYMAFFEFNSRLES
:.:....:..: : .:..:. :..:.:. :: : ::..: : ::: .::::: .:::
XP_011 IVDSNELRKHYRTSTKFQLDVASIIPFDICYLFFGFNPMFRANRMLKYTSFFEFNHHLES
150 160 170 180 190 200
790 800 810 820 830 840
pF1KB7 ILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYDGVGNSYIRCYYFAVK
:..:::.:::::::.:::. ::.:.:.::::: :.:.:.:.::::: :: :.::::.::.
XP_011 IMDKAYIYRVIRTTGYLLFILHINACVYYWASNYEGIGTTRWVYDGEGNEYLRCYYWAVR
210 220 230 240 250 260
850 860 870 880 890 900
pF1KB7 TLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTV
:::::::::.:.:::::::::::.:.:::.:: .:::::::.:::::.:.:.:.:::.:.
XP_011 TLITIGGLPEPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTI
270 280 290 300 310 320
910 920 930 940 950 960
pF1KB7 KYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVA
::: :.::: ::.::.::::::: :: :::::.:. :: ..: ::::::..:.:::
XP_011 AYMNNYSIPKLVQKRVRTWYEYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVD
330 340 350 360 370 380
970 980 990 1000 1010 1020
pF1KB7 LFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVT
::.::: :::.::: ::.::.:::.:.::::::::.:::::. :.::::::::: .::::
XP_011 LFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGTKVLVT
390 400 410 420 430 440
1030 1040 1050 1060 1070 1080
pF1KB7 LKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKAR
::::::::::::::.:::::::::::::::.::. :::: :.:::::::.:...: ::::
XP_011 LKAGSVFGEISLLAAGGGNRRTANVVAHGFANLLTLDKKTLQEILVHYPDSERILMKKAR
450 460 470 480 490 500
1090 1100 1110 1120 1130
pF1KB7 RMLRSNNK-----PKEEKSVLILPPRAGTPKLFNAALAMTGKMGGKGAKGGKLAHLRARL
.:... : : .. .:..::. :::::.. :. ::: ..::.: .:
XP_011 VLLKQKAKTAEATPPRKDLALLFPPKEETPKLFKTLLGGTGK--------ASLARL-LKL
510 520 530 540 550
1140 1150 1160 1170 1180 1190
pF1KB7 KELAALEAAAKQQELVEQAKSSQDVKGEEGSAAPDQHTHPKEAATDPPAPRTPPEPPGSP
:. : . ... :..: ..: . :. . ... . :: : : : : : .
XP_011 KREQAAQKKENSEGGEEEGKENEDKQKENEDKQKENEDKGKENE-DKDKGREPEEKPLDR
560 570 580 590 600 610
1200 1210 1220 1230 1240 1250
pF1KB7 P--SSPPPASLGRPEGEEEG--PAEPEEHSVRICMSPGPEPGEQILSVKMPEEREEKAE
: .. : : .:.. .. : ..:. : :.:. : ::..:.... :. ..
XP_011 PECTASPIAVEEEPHSVRRTVLPRGTSRQSLIISMAPSAEGGEEVLTIEVKEKAKQ
620 630 640 650 660 670
>>NP_001129111 (OMIM: 600724,613767) cyclic nucleotide-g (299 aa)
initn: 1998 init1: 1998 opt: 1998 Z-score: 1005.2 bits: 196.1 E(85289): 3e-49
Smith-Waterman score: 1998; 98.3% identity (98.7% similar) in 298 aa overlap (1-298:1-298)
10 20 30 40 50 60
pF1KB7 MLGWVQRVLPQPPGTPRKTKMQEEEEVEPEPEMEAEVEPEPNPEEAETESESMPPEESFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLGWVQRVLPQPPGTPRKTKMQEEEEVEPEPEMEAEVEPEPNPEEAETESESMPPEESFK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 EEEVAVADPSPQETKEAALTSTISLRAQGAEISEMNSPSRRVLTWLMKGVEKVIPQPVHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEEVAVADPSPQETKEAALTSTISLRAQGAEISEMNSPSRRVLTWLMKGVEKVIPQPVHS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 ITEDPAQILGHGSTGDTGCTDEPNEALEAQDTRPGLRLLLWLEQNLERVLPQPPKSSEVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITEDPAQILGHGSTGDTGCTDEPNEALEAQDTRPGLRLLLWLEQNLERVLPQPPKSSEVW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 RDEPAVATGAASDPAPPGRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPAPEPQPGSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDEPAVATGAASDPAPPGRPQEMGPKLQARETPSLPTPIPLQPKEEPKEAPAPEPQPGSQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 AQTSSLPPTRDPARLVAWVLHRLEMALPQPVLHGKIGEQEPDSPGICDVQTISILPGGQV
::::::::::::::::::::::::::::::::::::::::::::::::::: . ::
NP_001 AQTSSLPPTRDPARLVAWVLHRLEMALPQPVLHGKIGEQEPDSPGICDVQTRVMGAGGL
250 260 270 280 290
310 320 330 340 350 360
pF1KB7 EPDLVLEEVEPPWEDAHQDVSTSPQGTEVVPAYEEENKAVEKMPRELSRIEEEKEDEEEE
>>XP_006712306 (OMIM: 216900,600053) PREDICTED: cyclic n (731 aa)
initn: 971 init1: 482 opt: 966 Z-score: 492.9 bits: 102.6 E(85289): 1e-20
Smith-Waterman score: 1116; 29.2% identity (60.3% similar) in 736 aa overlap (461-1171:12-722)
440 450 460 470 480
pF1KB7 EEAEKEPQDWAETKEEPEAEAEAASSGVPATKQHPEVQVEDTDADSCP-----LMAEENP
.. : .:.. : : . . .
XP_006 MAKINTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEE
10 20 30 40
490 500 510 520 530 540
pF1KB7 PSTVLPPPSPAKSDTLIVPSSAS----GTHRKKLPSEDDEAEELKALSPAESPVVAWSDP
:.:: : .. : ...: : : .. .. :.. . :...:..
XP_006 TSSVLQPGIAMETRGLADSGQGSFTGQGIARFGRIQKKSQPEKVVRAASRGRPLIGWTQW
50 60 70 80 90 100
550 560 570 580 590 600
pF1KB7 TTPKDTDGQDRAASTASTNSAIINDRLQELVKLFKERTEK-VKEKLIDPDVTSDEESPKP
. : .. : . . :. . ::..:. :... . . :... :: :.
XP_006 CAEDGGDESEMALAGSPGCSSGPQGRLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAE
110 120 130 140 150 160
610 620 630 640 650 660
pF1KB7 SPAKKAPEPAPDTKPAEAEPVEEEHYCDMLCCKFKHRPWKKYQFPQSIDPLTNLMYVLWL
.. : ... . ::... .: : . .:: .::.: ::
XP_006 LKEVSSQESNAQANVGSQEPADR-----------GRRKKTKKKDAIVVDPSSNLYYR-WL
170 180 190 200
670 680 690 700 710 720
pF1KB7 FFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVRGGD
... .: .:. : : . . ::..:: :..: ::. : ..: :.. :
XP_006 TAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVLV-RARTGFLEQGL
210 220 230 240 250 260
730 740 750 760 770
pF1KB7 IITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVN-PLLRLPRCLKYMAFFEFNSRL
...: . . ..: . .::.:.:::.: :. :::::.: : .:. : ::. .::: .:
XP_006 MVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRT
270 280 290 300 310 320
780 790 800 810 820 830
pF1KB7 ESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYDGVG--------NS
:. . ..:. . :.: .: :.:.:. : . :.:. ::: ... .
XP_006 ETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRK
330 340 350 360 370 380
840 850 860 870 880 890
pF1KB7 YIRCYYFAVKTLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQT
:: :... :: ::: : : : .: ......::. :....:.. .... .:...
XP_006 YIYSLYWSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRA
390 400 410 420 430 440
900 910 920 930 940 950
pF1KB7 YYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAID
... .:: .::.: :. :....:: :..: : .. .::.:.. .::::.. ..::.
XP_006 EFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAIN
450 460 470 480 490 500
960 970 980 990 1000 1010
pF1KB7 VNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLG
:. . ..:: .:: :. .. ... .:: .:. :.::.::::.::.:::::. :.. :..
XP_006 VHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVA
510 520 530 540 550 560
1020 1030 1040 1050 1060
pF1KB7 GPDGKSVLVTLKAGSVFGEISLLAVGG---GNRRTANVVAHGFTNLFILDKKDLNEILVH
:: . .:.:. :: :::::.: . : :::::::. . :...:: :.: :: : :..
XP_006 D-DGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTE
570 580 590 600 610 620
1070 1080 1090 1100 1110 1120
pF1KB7 YPESQKLLRKKARRMLRSNNKPKEEKSVLILPPRAGT-PKLFNAALAMTGKMGGKGAKGG
:::..: :..:.:..: ..: :: . :::. :: .. . . :. . .
XP_006 YPEAKKALEEKGRQILMKDNLIDEELA------RAGADPKDLEEKVEQLGS--SLDTLQT
630 640 650 660 670
1130 1140 1150 1160 1170 1180
pF1KB7 KLAHLRARLKELAALEAAAKQQ--ELVEQAKSSQDVKGEEGSAAPDQHTHPKEAATDPPA
..:.: : : : . ::. .: :.:.. : .: . :
XP_006 RFARL---LAEYNATQMKMKQRLSQLESQVKGGGDKPLADGEVPGDATKTEDKQQ
680 690 700 710 720 730
1190 1200 1210 1220 1230 1240
pF1KB7 PRTPPEPPGSPPSSPPPASLGRPEGEEEGPAEPEEHSVRICMSPGPEPGEQILSVKMPEE
>>NP_001073347 (OMIM: 216900,600053) cyclic nucleotide-g (676 aa)
initn: 971 init1: 482 opt: 960 Z-score: 490.4 bits: 102.0 E(85289): 1.4e-20
Smith-Waterman score: 1110; 31.2% identity (62.2% similar) in 686 aa overlap (505-1171:9-667)
480 490 500 510 520 530
pF1KB7 DSCPLMAEENPPSTVLPPPSPAKSDTLIVPSSASGTHRKKLPSEDDEAEELKALSPAESP
: : :: : :. : . ..:: :.:
NP_001 MAKINTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSS
10 20 30
540 550 560 570 580 590
pF1KB7 VVAWSD---PTTPKDTDGQDRAASTASTNSAIINDRLQELVKLFKERTEK-VKEKLIDPD
:. : .: : ... . :...: ::..:. :... . . :... ::
NP_001 SEETSSVLQPGIAMETRGLADSGQGSFTGQGIA--RLSRLIFLLRRWAARHVHHQDQGPD
40 50 60 70 80 90
600 610 620 630 640 650
pF1KB7 VTSDEESPKPSPAKKAPEPAPDTKPAEAEPVEEEHYCDMLCCKFKHRPWKKYQFPQSIDP
:. .. : ... . ::... . ... :: . .::
NP_001 SFPDRFRGAELKEVSSQESNAQANVGSQEPADRGR---------RKKTKKKDAI--VVDP
100 110 120 130 140
660 670 680 690 700 710
pF1KB7 LTNLMYVLWLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQ
.::.: :: ... .: .:. : : . . ::..:: :..: ::. : .
NP_001 SSNLYYR-WLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVLV-R
150 160 170 180 190 200
720 730 740 750 760
pF1KB7 TRLQFVRGGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVN-PLLRLPRCLKY
.: :.. : ...: . . ..: . .::.:.:::.: :. :::::.: : .:. : ::.
NP_001 ARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKF
210 220 230 240 250 260
770 780 790 800 810 820
pF1KB7 MAFFEFNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYDGVG
.::: .: :. . ..:. . :.: .: :.:.:. : . :.:. ::: ...
NP_001 SRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNIS
270 280 290 300 310 320
830 840 850 860 870 880
pF1KB7 --------NSYIRCYYFAVKTLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRD
.:: :... :: ::: : : : .: ......::. :....:.. .
NP_001 IPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGS
330 340 350 360 370 380
890 900 910 920 930 940
pF1KB7 VVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLP
... .:... ... .:: .::.: :. :....:: :..: : .. .::.:.. .::
NP_001 MISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLP
390 400 410 420 430 440
950 960 970 980 990 1000
pF1KB7 DKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYI
::.. ..::.:. . ..:: .:: :. .. ... .:: .:. :.::.::::.::.::::
NP_001 DKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYI
450 460 470 480 490 500
1010 1020 1030 1040 1050
pF1KB7 IQAGQVQVLGGPDGKSVLVTLKAGSVFGEISLLAVGG---GNRRTANVVAHGFTNLFILD
:. :.. :.. :: . .:.:. :: :::::.: . : :::::::. . :...:: :.
NP_001 INEGKLAVVAD-DGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLS
510 520 530 540 550 560
1060 1070 1080 1090 1100 1110
pF1KB7 KKDLNEILVHYPESQKLLRKKARRMLRSNNKPKEEKSVLILPPRAGT-PKLFNAALAMTG
: :: : :..:::..: :..:.:..: ..: :: . :::. :: .. . . :
NP_001 KDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELA------RAGADPKDLEEKVEQLG
570 580 590 600 610
1120 1130 1140 1150 1160 1170
pF1KB7 KMGGKGAKGGKLAHLRARLKELAALEAAAKQQ--ELVEQAKSSQDVKGEEGSAAPDQHTH
. . . ..:.: : : : . ::. .: :.:.. : .: . :
NP_001 S--SLDTLQTRFARL---LAEYNATQMKMKQRLSQLESQVKGGGDKPLADGEVPGDATKT
620 630 640 650 660 670
1180 1190 1200 1210 1220 1230
pF1KB7 PKEAATDPPAPRTPPEPPGSPPSSPPPASLGRPEGEEEGPAEPEEHSVRICMSPGPEPGE
NP_001 EDKQQ
>>NP_001289 (OMIM: 216900,600053) cyclic nucleotide-gate (694 aa)
initn: 971 init1: 482 opt: 944 Z-score: 482.4 bits: 100.6 E(85289): 4e-20
Smith-Waterman score: 1114; 31.4% identity (61.7% similar) in 695 aa overlap (505-1171:9-685)
480 490 500 510 520 530
pF1KB7 DSCPLMAEENPPSTVLPPPSPAKSDTLIVPSSASGTHRKKLPSEDDEAEELKALSPAESP
: : :: : :. : . ..:: :.:
NP_001 MAKINTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSS
10 20 30
540 550 560 570 580 590
pF1KB7 VVAWSD---PTTPKDTDGQDRAASTASTNSAIINDRLQELVKLFKERTEK-VKEKLIDPD
:. : .: : ... . :...: ::..:. :... . . :... ::
NP_001 SEETSSVLQPGIAMETRGLADSGQGSFTGQGIA--RLSRLIFLLRRWAARHVHHQDQGPD
40 50 60 70 80 90
600 610 620 630 640
pF1KB7 VTSD--------EESPKPSPAK-KAPEPAPDTKPAEAEPVEEEHYCDMLCCKFKHRPWKK
: : : . : :. .. : . : :. . . . ... ::
NP_001 SFPDRFRGAELKEVSSQESNAQANVGSQEPADRGRSAWPLAKCNTNTSNNTEEEKKTKKK
100 110 120 130 140 150
650 660 670 680 690 700
pF1KB7 YQFPQSIDPLTNLMYVLWLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLI
. .:: .::.: :: ... .: .:. : : . . ::..:: :..
NP_001 DAI--VVDPSSNLYYR-WLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYSADVL
160 170 180 190 200 210
710 720 730 740 750 760
pF1KB7 YFLDITVFQTRLQFVRGGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVN-PL
: ::. : ..: :.. : ...: . . ..: . .::.:.:::.: :. :::::.: :
NP_001 YVLDVLV-RARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPE
220 230 240 250 260 270
770 780 790 800 810 820
pF1KB7 LRLPRCLKYMAFFEFNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGS
.:. : ::. .::: .: :. . ..:. . :.: .: :.:.:. : . :.:.
NP_001 VRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGT
280 290 300 310 320 330
830 840 850 860 870
pF1KB7 THWVYDGVG--------NSYIRCYYFAVKTLITIGGLPDPKTLFEIVFQLLNYFTGVFAF
::: ... .:: :... :: ::: : : : .: ......::. :
NP_001 DSWVYPNISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIF
340 350 360 370 380 390
880 890 900 910 920 930
pF1KB7 SVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLD
....:.. .... .:... ... .:: .::.: :. :....:: :..: : .. .:
NP_001 ATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVD
400 410 420 430 440 450
940 950 960 970 980 990
pF1KB7 ESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKK
:.:.. .::::.. ..::.:. . ..:: .:: :. .. ... .:: .:. :.::.:::
NP_001 EKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKK
460 470 480 490 500 510
1000 1010 1020 1030 1040
pF1KB7 GEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVFGEISLLAVGG---GNRRTANVVAH
:.::.:::::. :.. :.. :: . .:.:. :: :::::.: . : :::::::. .
NP_001 GDIGKEMYIINEGKLAVVAD-DGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSI
520 530 540 550 560 570
1050 1060 1070 1080 1090 1100
pF1KB7 GFTNLFILDKKDLNEILVHYPESQKLLRKKARRMLRSNNKPKEEKSVLILPPRAGT-PKL
:...:: :.: :: : :..:::..: :..:.:..: ..: :: . :::. ::
NP_001 GYSDLFCLSKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELA------RAGADPKD
580 590 600 610 620
1110 1120 1130 1140 1150 1160
pF1KB7 FNAALAMTGKMGGKGAKGGKLAHLRARLKELAALEAAAKQQ--ELVEQAKSSQDVKGEEG
.. . . :. . . ..:.: : : : . ::. .: :.:.. : .:
NP_001 LEEKVEQLGS--SLDTLQTRFARL---LAEYNATQMKMKQRLSQLESQVKGGGDKPLADG
630 640 650 660 670 680
1170 1180 1190 1200 1210 1220
pF1KB7 SAAPDQHTHPKEAATDPPAPRTPPEPPGSPPSSPPPASLGRPEGEEEGPAEPEEHSVRIC
. :
NP_001 EVPGDATKTEDKQQ
690
>>XP_011508856 (OMIM: 216900,600053) PREDICTED: cyclic n (749 aa)
initn: 971 init1: 482 opt: 944 Z-score: 481.9 bits: 100.6 E(85289): 4.2e-20
Smith-Waterman score: 1120; 29.4% identity (60.3% similar) in 745 aa overlap (461-1171:12-740)
440 450 460 470 480
pF1KB7 EEAEKEPQDWAETKEEPEAEAEAASSGVPATKQHPEVQVEDTDADSCP-----LMAEENP
.. : .:.. : : . . .
XP_011 MAKINTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEE
10 20 30 40
490 500 510 520 530 540
pF1KB7 PSTVLPPPSPAKSDTLIVPSSAS----GTHRKKLPSEDDEAEELKALSPAESPVVAWSDP
:.:: : .. : ...: : : .. .. :.. . :...:..
XP_011 TSSVLQPGIAMETRGLADSGQGSFTGQGIARFGRIQKKSQPEKVVRAASRGRPLIGWTQW
50 60 70 80 90 100
550 560 570 580 590
pF1KB7 TTPKDTDGQDRAASTASTNSAIINDRLQELVKLFKERTEK-VKEKLIDPDVTSD------
. : .. : . . :. . ::..:. :... . . :... :: :
XP_011 CAEDGGDESEMALAGSPGCSSGPQGRLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAE
110 120 130 140 150 160
600 610 620 630 640 650
pF1KB7 --EESPKPSPAK-KAPEPAPDTKPAEAEPVEEEHYCDMLCCKFKHRPWKKYQFPQSIDPL
: : . : :. .. : . : :. . . . ... :: . .::
XP_011 LKEVSSQESNAQANVGSQEPADRGRSAWPLAKCNTNTSNNTEEEKKTKKKDAI--VVDPS
170 180 190 200 210
660 670 680 690 700 710
pF1KB7 TNLMYVLWLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQT
.::.: :: ... .: .:. : : . . ::..:: :..: ::. : ..
XP_011 SNLYYR-WLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVLV-RA
220 230 240 250 260 270
720 730 740 750 760 770
pF1KB7 RLQFVRGGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVN-PLLRLPRCLKYM
: :.. : ...: . . ..: . .::.:.:::.: :. :::::.: : .:. : ::.
XP_011 RTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFS
280 290 300 310 320 330
780 790 800 810 820
pF1KB7 AFFEFNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTHWVYDGVG-
.::: .: :. . ..:. . :.: .: :.:.:. : . :.:. ::: ...
XP_011 RLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISI
340 350 360 370 380 390
830 840 850 860 870 880
pF1KB7 -------NSYIRCYYFAVKTLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDV
.:: :... :: ::: : : : .: ......::. :....:.. ..
XP_011 PEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSM
400 410 420 430 440 450
890 900 910 920 930 940
pF1KB7 VGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPD
.. .:... ... .:: .::.: :. :....:: :..: : .. .::.:.. .:::
XP_011 ISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPD
460 470 480 490 500 510
950 960 970 980 990 1000
pF1KB7 KMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYII
:.. ..::.:. . ..:: .:: :. .. ... .:: .:. :.::.::::.::.:::::
XP_011 KLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYII
520 530 540 550 560 570
1010 1020 1030 1040 1050
pF1KB7 QAGQVQVLGGPDGKSVLVTLKAGSVFGEISLLAVGG---GNRRTANVVAHGFTNLFILDK
. :.. :.. :: . .:.:. :: :::::.: . : :::::::. . :...:: :.:
XP_011 NEGKLAVVAD-DGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSK
580 590 600 610 620 630
1060 1070 1080 1090 1100 1110
pF1KB7 KDLNEILVHYPESQKLLRKKARRMLRSNNKPKEEKSVLILPPRAGT-PKLFNAALAMTGK
:: : :..:::..: :..:.:..: ..: :: . :::. :: .. . . :.
XP_011 DDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELA------RAGADPKDLEEKVEQLGS
640 650 660 670 680 690
1120 1130 1140 1150 1160 1170
pF1KB7 MGGKGAKGGKLAHLRARLKELAALEAAAKQQ--ELVEQAKSSQDVKGEEGSAAPDQHTHP
. . ..:.: : : : . ::. .: :.:.. : .: . :
XP_011 --SLDTLQTRFARL---LAEYNATQMKMKQRLSQLESQVKGGGDKPLADGEVPGDATKTE
700 710 720 730 740
1180 1190 1200 1210 1220 1230
pF1KB7 KEAATDPPAPRTPPEPPGSPPSSPPPASLGRPEGEEEGPAEPEEHSVRICMSPGPEPGEQ
XP_011 DKQQ
1251 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 08:31:14 2016 done: Sat Nov 5 08:31:17 2016
Total Scan time: 19.250 Total Display time: 0.270
Function used was FASTA [36.3.4 Apr, 2011]