FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7305, 810 aa 1>>>pF1KB7305 810 - 810 aa - 810 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.9239+/-0.000544; mu= -5.8599+/- 0.034 mean_var=419.6220+/-88.956, 0's: 0 Z-trim(116.4): 192 B-trim: 357 in 1/55 Lambda= 0.062610 statistics sampled from 27353 (27547) to 27353 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.657), E-opt: 0.2 (0.323), width: 16 Scan time: 13.520 The best scores are: opt bits E(85289) NP_005656 (OMIM: 602942) ecotropic viral integrati ( 810) 5238 488.8 3.9e-137 XP_016857772 (OMIM: 602942) PREDICTED: ecotropic v ( 785) 3025 288.9 5.7e-77 XP_016857760 (OMIM: 602942) PREDICTED: ecotropic v ( 903) 3025 289.0 6.3e-77 NP_001295177 (OMIM: 602942) ecotropic viral integr ( 821) 2961 283.2 3.2e-75 XP_016857766 (OMIM: 602942) PREDICTED: ecotropic v ( 854) 2949 282.1 7e-75 XP_016857770 (OMIM: 602942) PREDICTED: ecotropic v ( 818) 2864 274.4 1.4e-72 XP_016857774 (OMIM: 602942) PREDICTED: ecotropic v ( 741) 2754 264.4 1.3e-69 XP_016857769 (OMIM: 602942) PREDICTED: ecotropic v ( 826) 2754 264.5 1.4e-69 XP_016857765 (OMIM: 602942) PREDICTED: ecotropic v ( 859) 2754 264.5 1.4e-69 XP_016857773 (OMIM: 602942) PREDICTED: ecotropic v ( 777) 2690 258.7 7.3e-68 XP_016857767 (OMIM: 602942) PREDICTED: ecotropic v ( 848) 2397 232.2 7.2e-60 XP_016857761 (OMIM: 602942) PREDICTED: ecotropic v ( 897) 2384 231.1 1.7e-59 XP_016857771 (OMIM: 602942) PREDICTED: ecotropic v ( 812) 2066 202.3 7e-51 XP_016857768 (OMIM: 602942) PREDICTED: ecotropic v ( 841) 2066 202.3 7.1e-51 XP_016857764 (OMIM: 602942) PREDICTED: ecotropic v ( 886) 2066 202.4 7.4e-51 XP_016857762 (OMIM: 602942) PREDICTED: ecotropic v ( 886) 2066 202.4 7.4e-51 XP_016857763 (OMIM: 602942) PREDICTED: ecotropic v ( 886) 2066 202.4 7.4e-51 XP_016857759 (OMIM: 602942) PREDICTED: ecotropic v ( 927) 2066 202.4 7.6e-51 XP_016857758 (OMIM: 602942) PREDICTED: ecotropic v ( 930) 2066 202.4 7.6e-51 XP_016857775 (OMIM: 602942) PREDICTED: ecotropic v ( 722) 1880 185.5 7.3e-46 XP_016857777 (OMIM: 602942) PREDICTED: ecotropic v ( 722) 1880 185.5 7.3e-46 XP_016857776 (OMIM: 602942) PREDICTED: ecotropic v ( 722) 1880 185.5 7.3e-46 XP_005245738 (OMIM: 609238) PREDICTED: rab GTPase- (1014) 898 96.9 4.7e-19 XP_011508525 (OMIM: 609238) PREDICTED: rab GTPase- (1051) 898 96.9 4.8e-19 XP_005245737 (OMIM: 609238) PREDICTED: rab GTPase- (1051) 898 96.9 4.8e-19 XP_006711756 (OMIM: 609238) PREDICTED: rab GTPase- ( 985) 891 96.3 7.1e-19 XP_016870059 (OMIM: 615882) PREDICTED: rab GTPase- ( 900) 890 96.1 7.1e-19 XP_011516744 (OMIM: 615882) PREDICTED: rab GTPase- ( 900) 890 96.1 7.1e-19 NP_036329 (OMIM: 615882) rab GTPase-activating pro (1069) 890 96.2 8e-19 XP_016870058 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 890 96.2 8e-19 XP_016870057 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 890 96.2 8e-19 XP_011516743 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 890 96.2 8e-19 XP_011516742 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 890 96.2 8e-19 XP_016870056 (OMIM: 615882) PREDICTED: rab GTPase- (1069) 890 96.2 8e-19 XP_016858483 (OMIM: 609238) PREDICTED: rab GTPase- ( 778) 837 91.3 1.8e-17 NP_055672 (OMIM: 609238) rab GTPase-activating pro ( 815) 837 91.3 1.8e-17 XP_016876373 (OMIM: 612465,616087) PREDICTED: TBC1 ( 487) 589 68.7 7.1e-11 XP_011511972 (OMIM: 609850) PREDICTED: TBC1 domain ( 494) 583 68.1 1e-10 XP_006714064 (OMIM: 609850) PREDICTED: TBC1 domain ( 546) 583 68.2 1.1e-10 XP_016876372 (OMIM: 612465,616087) PREDICTED: TBC1 (1017) 589 69.0 1.2e-10 XP_016876371 (OMIM: 612465,616087) PREDICTED: TBC1 (1054) 589 69.0 1.2e-10 XP_005266662 (OMIM: 612465,616087) PREDICTED: TBC1 (1117) 589 69.1 1.3e-10 XP_006719966 (OMIM: 612465,616087) PREDICTED: TBC1 (1140) 589 69.1 1.3e-10 NP_001273588 (OMIM: 612465,616087) TBC1 domain fam (1235) 589 69.1 1.3e-10 XP_011533633 (OMIM: 612465,616087) PREDICTED: TBC1 (1261) 589 69.1 1.4e-10 XP_005266660 (OMIM: 612465,616087) PREDICTED: TBC1 (1273) 589 69.1 1.4e-10 NP_001273587 (OMIM: 612465,616087) TBC1 domain fam (1290) 589 69.1 1.4e-10 NP_055647 (OMIM: 612465,616087) TBC1 domain family (1298) 589 69.1 1.4e-10 XP_016863410 (OMIM: 609850) PREDICTED: TBC1 domain (1039) 583 68.5 1.7e-10 XP_005262706 (OMIM: 609850) PREDICTED: TBC1 domain (1146) 583 68.5 1.9e-10 >>NP_005656 (OMIM: 602942) ecotropic viral integration s (810 aa) initn: 5238 init1: 5238 opt: 5238 Z-score: 2583.0 bits: 488.8 E(85289): 3.9e-137 Smith-Waterman score: 5238; 100.0% identity (100.0% similar) in 810 aa overlap (1-810:1-810) 10 20 30 40 50 60 pF1KB7 MVTNKMTAAFRNPSGKQVATDKVAEKLSSTLSWVKNTVSHTVSQMASQVASPSTSLHTTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MVTNKMTAAFRNPSGKQVATDKVAEKLSSTLSWVKNTVSHTVSQMASQVASPSTSLHTTS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 SSTTLSTPALSPSSPSQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SSTTLSTPALSPSSPSQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 SSASSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SSASSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 SMPIKDQYSELLKMTSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SMPIKDQYSELLKMTSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDRE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 VGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 HLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 HLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 QMNQAELMQLDMEGMLQHFQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 QMNQAELMQLDMEGMLQHFQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIKT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB7 KEMEEQVEIKRLRTENRLLKQRIETLEKHKCSSNYNEDFVLQLEKELVQARLSEAESQCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 KEMEEQVEIKRLRTENRLLKQRIETLEKHKCSSNYNEDFVLQLEKELVQARLSEAESQCA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB7 LKEMQDKVLDIEKRNNSLPDENNIARLQEELIAVKLREAEAIMGLKELRQQVKDLEEHWQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LKEMQDKVLDIEKRNNSLPDENNIARLQEELIAVKLREAEAIMGLKELRQQVKDLEEHWQ 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB7 RHLARTTGRWKDPPKKNAMNELQDELMTIRLREAETQAEIREIKQRMMEMETQNQINSNH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 RHLARTTGRWKDPPKKNAMNELQDELMTIRLREAETQAEIREIKQRMMEMETQNQINSNH 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB7 LRRAEQEVISLQEKVQYLSAQNKGLLTQLSEAKRKQAEIECKNKEEVMAVRLREADSIAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LRRAEQEVISLQEKVQYLSAQNKGLLTQLSEAKRKQAEIECKNKEEVMAVRLREADSIAA 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB7 VAELRQHIAELEIQKEEGKLQGQLNKSDSNQYIGELKDQIAELNHELRCLKGQRGFSGQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VAELRQHIAELEIQKEEGKLQGQLNKSDSNQYIGELKDQIAELNHELRCLKGQRGFSGQP 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB7 PFDGIHIVNHLIGDDESFHSSDEDFIDNSLQETGVGFPLHGKSGSMSLDPAVADGSESET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PFDGIHIVNHLIGDDESFHSSDEDFIDNSLQETGVGFPLHGKSGSMSLDPAVADGSESET 730 740 750 760 770 780 790 800 810 pF1KB7 EDSVLETRESNQVVQKERPPRRRESYSTTV :::::::::::::::::::::::::::::: NP_005 EDSVLETRESNQVVQKERPPRRRESYSTTV 790 800 810 >>XP_016857772 (OMIM: 602942) PREDICTED: ecotropic viral (785 aa) initn: 4592 init1: 2909 opt: 3025 Z-score: 1502.8 bits: 288.9 E(85289): 5.7e-77 Smith-Waterman score: 4410; 92.2% identity (92.2% similar) in 766 aa overlap (1-706:1-766) 10 20 30 40 50 60 pF1KB7 MVTNKMTAAFRNPSGKQVATDKVAEKLSSTLSWVKNTVSHTVSQMASQVASPSTSLHTTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MVTNKMTAAFRNPSGKQVATDKVAEKLSSTLSWVKNTVSHTVSQMASQVASPSTSLHTTS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 SSTTLSTPALSPSSPSQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSTTLSTPALSPSSPSQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 SSASSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSASSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 SMPIKDQYSELLKMTSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SMPIKDQYSELLKMTSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDRE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 VGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 HLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 QMNQAELMQLDMEGMLQHFQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QMNQAELMQLDMEGMLQHFQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIKT 370 380 390 400 410 420 430 440 pF1KB7 KEMEEQVEIKRLRTENRLLKQRIETLEK-------------------------------- :::::::::::::::::::::::::::: XP_016 KEMEEQVEIKRLRTENRLLKQRIETLEKESASLADRLIQGQVTRAQEAEENYLIKRELAT 430 440 450 460 470 480 450 460 470 480 pF1KB7 ----------------------------HKCSSNYNEDFVLQLEKELVQARLSEAESQCA :::::::::::::::::::::::::::::::: XP_016 IKQQSDEASAKLEQAENTIRKLQHQQQWHKCSSNYNEDFVLQLEKELVQARLSEAESQCA 490 500 510 520 530 540 490 500 510 520 530 540 pF1KB7 LKEMQDKVLDIEKRNNSLPDENNIARLQEELIAVKLREAEAIMGLKELRQQVKDLEEHWQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LKEMQDKVLDIEKRNNSLPDENNIARLQEELIAVKLREAEAIMGLKELRQQVKDLEEHWQ 550 560 570 580 590 600 550 560 570 580 590 600 pF1KB7 RHLARTTGRWKDPPKKNAMNELQDELMTIRLREAETQAEIREIKQRMMEMETQNQINSNH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RHLARTTGRWKDPPKKNAMNELQDELMTIRLREAETQAEIREIKQRMMEMETQNQINSNH 610 620 630 640 650 660 610 620 630 640 650 660 pF1KB7 LRRAEQEVISLQEKVQYLSAQNKGLLTQLSEAKRKQAEIECKNKEEVMAVRLREADSIAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LRRAEQEVISLQEKVQYLSAQNKGLLTQLSEAKRKQAEIECKNKEEVMAVRLREADSIAA 670 680 690 700 710 720 670 680 690 700 710 720 pF1KB7 VAELRQHIAELEIQKEEGKLQGQLNKSDSNQYIGELKDQIAELNHELRCLKGQRGFSGQP :::::::::::::::::::::::::::::::::::::::::::::: XP_016 VAELRQHIAELEIQKEEGKLQGQLNKSDSNQYIGELKDQIAELNHESTSAQVPKRPEGLL 730 740 750 760 770 780 730 740 750 760 770 780 pF1KB7 PFDGIHIVNHLIGDDESFHSSDEDFIDNSLQETGVGFPLHGKSGSMSLDPAVADGSESET XP_016 RPTSF >>XP_016857760 (OMIM: 602942) PREDICTED: ecotropic viral (903 aa) initn: 5276 init1: 2909 opt: 3025 Z-score: 1502.1 bits: 289.0 E(85289): 6.3e-77 Smith-Waterman score: 4642; 89.0% identity (89.0% similar) in 842 aa overlap (1-749:1-842) 10 20 30 40 50 60 pF1KB7 MVTNKMTAAFRNPSGKQVATDKVAEKLSSTLSWVKNTVSHTVSQMASQVASPSTSLHTTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MVTNKMTAAFRNPSGKQVATDKVAEKLSSTLSWVKNTVSHTVSQMASQVASPSTSLHTTS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 SSTTLSTPALSPSSPSQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSTTLSTPALSPSSPSQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 SSASSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSASSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 SMPIKDQYSELLKMTSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SMPIKDQYSELLKMTSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDRE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 VGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 HLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 QMNQAELMQLDMEGMLQHFQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QMNQAELMQLDMEGMLQHFQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIKT 370 380 390 400 410 420 430 440 pF1KB7 KEMEEQVEIKRLRTENRLLKQRIETLEK-------------------------------- :::::::::::::::::::::::::::: XP_016 KEMEEQVEIKRLRTENRLLKQRIETLEKESASLADRLIQGQVTRAQEAEENYLIKRELAT 430 440 450 460 470 480 450 460 470 480 pF1KB7 ----------------------------HKCSSNYNEDFVLQLEKELVQARLSEAESQCA :::::::::::::::::::::::::::::::: XP_016 IKQQSDEASAKLEQAENTIRKLQHQQQWHKCSSNYNEDFVLQLEKELVQARLSEAESQCA 490 500 510 520 530 540 490 500 510 520 530 540 pF1KB7 LKEMQDKVLDIEKRNNSLPDENNIARLQEELIAVKLREAEAIMGLKELRQQVKDLEEHWQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LKEMQDKVLDIEKRNNSLPDENNIARLQEELIAVKLREAEAIMGLKELRQQVKDLEEHWQ 550 560 570 580 590 600 550 560 570 580 590 600 pF1KB7 RHLARTTGRWKDPPKKNAMNELQDELMTIRLREAETQAEIREIKQRMMEMETQNQINSNH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RHLARTTGRWKDPPKKNAMNELQDELMTIRLREAETQAEIREIKQRMMEMETQNQINSNH 610 620 630 640 650 660 610 620 630 640 650 660 pF1KB7 LRRAEQEVISLQEKVQYLSAQNKGLLTQLSEAKRKQAEIECKNKEEVMAVRLREADSIAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LRRAEQEVISLQEKVQYLSAQNKGLLTQLSEAKRKQAEIECKNKEEVMAVRLREADSIAA 670 680 690 700 710 720 670 680 690 700 pF1KB7 VAELRQHIAELEIQKEEGKLQGQLNKSDSNQYIGELKDQIAELNHE-------------- :::::::::::::::::::::::::::::::::::::::::::::: XP_016 VAELRQHIAELEIQKEEGKLQGQLNKSDSNQYIGELKDQIAELNHEGELGREGRNVIPDW 730 740 750 760 770 780 710 720 730 740 pF1KB7 -------------------LRCLKGQRGFSGQPPFDGIHIVNHLIGDDESFHSSDEDFID ::::::::::::::::::::::::::::::::::::::::: XP_016 HSPHAEGNLMSGKQHSSPTLRCLKGQRGFSGQPPFDGIHIVNHLIGDDESFHSSDEDFID 790 800 810 820 830 840 750 760 770 780 790 800 pF1KB7 NSLQETGVGFPLHGKSGSMSLDPAVADGSESETEDSVLETRESNQVVQKERPPRRRESYS :: XP_016 NSLQETGVGFPLHGKSGSMSLDPAVADGSESETEDSVLETRESNQVVQKERPPRRRESYS 850 860 870 880 890 900 >-- initn: 390 init1: 390 opt: 390 Z-score: 215.8 bits: 51.0 E(85289): 2.8e-05 Smith-Waterman score: 390; 100.0% identity (100.0% similar) in 61 aa overlap (750-810:843-903) 720 730 740 750 760 770 pF1KB7 PPFDGIHIVNHLIGDDESFHSSDEDFIDNSLQETGVGFPLHGKSGSMSLDPAVADGSESE :::::::::::::::::::::::::::::: XP_016 PPFDGIHIVNHLIGDDESFHSSDEDFIDNSLQETGVGFPLHGKSGSMSLDPAVADGSESE 820 830 840 850 860 870 780 790 800 810 pF1KB7 TEDSVLETRESNQVVQKERPPRRRESYSTTV ::::::::::::::::::::::::::::::: XP_016 TEDSVLETRESNQVVQKERPPRRRESYSTTV 880 890 900 >>NP_001295177 (OMIM: 602942) ecotropic viral integratio (821 aa) initn: 3041 init1: 2909 opt: 2961 Z-score: 1471.4 bits: 283.2 E(85289): 3.2e-75 Smith-Waterman score: 5206; 98.7% identity (98.7% similar) in 821 aa overlap (1-810:1-821) 10 20 30 40 50 60 pF1KB7 MVTNKMTAAFRNPSGKQVATDKVAEKLSSTLSWVKNTVSHTVSQMASQVASPSTSLHTTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MVTNKMTAAFRNPSGKQVATDKVAEKLSSTLSWVKNTVSHTVSQMASQVASPSTSLHTTS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 SSTTLSTPALSPSSPSQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSTTLSTPALSPSSPSQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 SSASSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSASSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 SMPIKDQYSELLKMTSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SMPIKDQYSELLKMTSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDRE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 VGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 HLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 QMNQAELMQLDMEGMLQHFQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QMNQAELMQLDMEGMLQHFQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIKT 370 380 390 400 410 420 430 440 450 460 pF1KB7 KEMEEQVEIKRLRTENRLLKQRIETLEK-----------HKCSSNYNEDFVLQLEKELVQ :::::::::::::::::::::::::::: ::::::::::::::::::::: NP_001 KEMEEQVEIKRLRTENRLLKQRIETLEKESASLADRLIQHKCSSNYNEDFVLQLEKELVQ 430 440 450 460 470 480 470 480 490 500 510 520 pF1KB7 ARLSEAESQCALKEMQDKVLDIEKRNNSLPDENNIARLQEELIAVKLREAEAIMGLKELR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ARLSEAESQCALKEMQDKVLDIEKRNNSLPDENNIARLQEELIAVKLREAEAIMGLKELR 490 500 510 520 530 540 530 540 550 560 570 580 pF1KB7 QQVKDLEEHWQRHLARTTGRWKDPPKKNAMNELQDELMTIRLREAETQAEIREIKQRMME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QQVKDLEEHWQRHLARTTGRWKDPPKKNAMNELQDELMTIRLREAETQAEIREIKQRMME 550 560 570 580 590 600 590 600 610 620 630 640 pF1KB7 METQNQINSNHLRRAEQEVISLQEKVQYLSAQNKGLLTQLSEAKRKQAEIECKNKEEVMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 METQNQINSNHLRRAEQEVISLQEKVQYLSAQNKGLLTQLSEAKRKQAEIECKNKEEVMA 610 620 630 640 650 660 650 660 670 680 690 700 pF1KB7 VRLREADSIAAVAELRQHIAELEIQKEEGKLQGQLNKSDSNQYIGELKDQIAELNHELRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VRLREADSIAAVAELRQHIAELEIQKEEGKLQGQLNKSDSNQYIGELKDQIAELNHELRC 670 680 690 700 710 720 710 720 730 740 750 760 pF1KB7 LKGQRGFSGQPPFDGIHIVNHLIGDDESFHSSDEDFIDNSLQETGVGFPLHGKSGSMSLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKGQRGFSGQPPFDGIHIVNHLIGDDESFHSSDEDFIDNSLQETGVGFPLHGKSGSMSLD 730 740 750 760 770 780 770 780 790 800 810 pF1KB7 PAVADGSESETEDSVLETRESNQVVQKERPPRRRESYSTTV ::::::::::::::::::::::::::::::::::::::::: NP_001 PAVADGSESETEDSVLETRESNQVVQKERPPRRRESYSTTV 790 800 810 820 >>XP_016857766 (OMIM: 602942) PREDICTED: ecotropic viral (854 aa) initn: 3681 init1: 2909 opt: 2949 Z-score: 1465.3 bits: 282.1 E(85289): 7e-75 Smith-Waterman score: 5050; 94.8% identity (94.8% similar) in 842 aa overlap (1-798:1-842) 10 20 30 40 50 60 pF1KB7 MVTNKMTAAFRNPSGKQVATDKVAEKLSSTLSWVKNTVSHTVSQMASQVASPSTSLHTTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MVTNKMTAAFRNPSGKQVATDKVAEKLSSTLSWVKNTVSHTVSQMASQVASPSTSLHTTS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 SSTTLSTPALSPSSPSQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSTTLSTPALSPSSPSQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 SSASSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSASSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 SMPIKDQYSELLKMTSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SMPIKDQYSELLKMTSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDRE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 VGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 HLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 QMNQAELMQLDMEGMLQHFQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QMNQAELMQLDMEGMLQHFQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIKT 370 380 390 400 410 420 430 440 450 460 pF1KB7 KEMEEQVEIKRLRTENRLLKQRIETLEK-----------HKCSSNYNEDFVLQLEKELVQ :::::::::::::::::::::::::::: ::::::::::::::::::::: XP_016 KEMEEQVEIKRLRTENRLLKQRIETLEKESASLADRLIQHKCSSNYNEDFVLQLEKELVQ 430 440 450 460 470 480 470 480 490 500 510 520 pF1KB7 ARLSEAESQCALKEMQDKVLDIEKRNNSLPDENNIARLQEELIAVKLREAEAIMGLKELR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ARLSEAESQCALKEMQDKVLDIEKRNNSLPDENNIARLQEELIAVKLREAEAIMGLKELR 490 500 510 520 530 540 530 540 550 560 570 580 pF1KB7 QQVKDLEEHWQRHLARTTGRWKDPPKKNAMNELQDELMTIRLREAETQAEIREIKQRMME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQVKDLEEHWQRHLARTTGRWKDPPKKNAMNELQDELMTIRLREAETQAEIREIKQRMME 550 560 570 580 590 600 590 600 610 620 630 640 pF1KB7 METQNQINSNHLRRAEQEVISLQEKVQYLSAQNKGLLTQLSEAKRKQAEIECKNKEEVMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 METQNQINSNHLRRAEQEVISLQEKVQYLSAQNKGLLTQLSEAKRKQAEIECKNKEEVMA 610 620 630 640 650 660 650 660 670 680 690 700 pF1KB7 VRLREADSIAAVAELRQHIAELEIQKEEGKLQGQLNKSDSNQYIGELKDQIAELNHE--- ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VRLREADSIAAVAELRQHIAELEIQKEEGKLQGQLNKSDSNQYIGELKDQIAELNHEGEL 670 680 690 700 710 720 710 720 730 pF1KB7 ------------------------------LRCLKGQRGFSGQPPFDGIHIVNHLIGDDE :::::::::::::::::::::::::::::: XP_016 GREGRNVIPDWHSPHAEGNLMSGKQHSSPTLRCLKGQRGFSGQPPFDGIHIVNHLIGDDE 730 740 750 760 770 780 740 750 760 770 780 790 pF1KB7 SFHSSDEDFIDNSLQETGVGFPLHGKSGSMSLDPAVADGSESETEDSVLETRESNQVVQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SFHSSDEDFIDNSLQETGVGFPLHGKSGSMSLDPAVADGSESETEDSVLETRESNQVVQK 790 800 810 820 830 840 800 810 pF1KB7 ERPPRRRESYSTTV :: XP_016 ERPPRRRESYSTTV 850 >>XP_016857770 (OMIM: 602942) PREDICTED: ecotropic viral (818 aa) initn: 2939 init1: 2807 opt: 2864 Z-score: 1424.0 bits: 274.4 E(85289): 1.4e-72 Smith-Waterman score: 5109; 97.8% identity (98.2% similar) in 814 aa overlap (8-810:5-818) 10 20 30 40 50 60 pF1KB7 MVTNKMTAAFRNPSGKQVATDKVAEKLSSTLSWVKNTVSHTVSQMASQVASPSTSLHTTS :... :: ::::::::::::::::::::::::::::::::::::::::::: XP_016 MTSGASLKLTSGFPVATDKVAEKLSSTLSWVKNTVSHTVSQMASQVASPSTSLHTTS 10 20 30 40 50 70 80 90 100 110 120 pF1KB7 SSTTLSTPALSPSSPSQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSTTLSTPALSPSSPSQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSS 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB7 SSASSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSASSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQ 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB7 SMPIKDQYSELLKMTSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SMPIKDQYSELLKMTSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDRE 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB7 VGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQE 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB7 HLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALL 300 310 320 330 340 350 370 380 390 400 410 420 pF1KB7 QMNQAELMQLDMEGMLQHFQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QMNQAELMQLDMEGMLQHFQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIKT 360 370 380 390 400 410 430 440 450 460 pF1KB7 KEMEEQVEIKRLRTENRLLKQRIETLEK-----------HKCSSNYNEDFVLQLEKELVQ :::::::::::::::::::::::::::: ::::::::::::::::::::: XP_016 KEMEEQVEIKRLRTENRLLKQRIETLEKESASLADRLIQHKCSSNYNEDFVLQLEKELVQ 420 430 440 450 460 470 470 480 490 500 510 520 pF1KB7 ARLSEAESQCALKEMQDKVLDIEKRNNSLPDENNIARLQEELIAVKLREAEAIMGLKELR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ARLSEAESQCALKEMQDKVLDIEKRNNSLPDENNIARLQEELIAVKLREAEAIMGLKELR 480 490 500 510 520 530 530 540 550 560 570 580 pF1KB7 QQVKDLEEHWQRHLARTTGRWKDPPKKNAMNELQDELMTIRLREAETQAEIREIKQRMME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QQVKDLEEHWQRHLARTTGRWKDPPKKNAMNELQDELMTIRLREAETQAEIREIKQRMME 540 550 560 570 580 590 590 600 610 620 630 640 pF1KB7 METQNQINSNHLRRAEQEVISLQEKVQYLSAQNKGLLTQLSEAKRKQAEIECKNKEEVMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 METQNQINSNHLRRAEQEVISLQEKVQYLSAQNKGLLTQLSEAKRKQAEIECKNKEEVMA 600 610 620 630 640 650 650 660 670 680 690 700 pF1KB7 VRLREADSIAAVAELRQHIAELEIQKEEGKLQGQLNKSDSNQYIGELKDQIAELNHELRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VRLREADSIAAVAELRQHIAELEIQKEEGKLQGQLNKSDSNQYIGELKDQIAELNHELRC 660 670 680 690 700 710 710 720 730 740 750 760 pF1KB7 LKGQRGFSGQPPFDGIHIVNHLIGDDESFHSSDEDFIDNSLQETGVGFPLHGKSGSMSLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LKGQRGFSGQPPFDGIHIVNHLIGDDESFHSSDEDFIDNSLQETGVGFPLHGKSGSMSLD 720 730 740 750 760 770 770 780 790 800 810 pF1KB7 PAVADGSESETEDSVLETRESNQVVQKERPPRRRESYSTTV ::::::::::::::::::::::::::::::::::::::::: XP_016 PAVADGSESETEDSVLETRESNQVVQKERPPRRRESYSTTV 780 790 800 810 >>XP_016857774 (OMIM: 602942) PREDICTED: ecotropic viral (741 aa) initn: 4259 init1: 2638 opt: 2754 Z-score: 1370.9 bits: 264.4 E(85289): 1.3e-69 Smith-Waterman score: 4139; 91.7% identity (91.7% similar) in 722 aa overlap (45-706:1-722) 20 30 40 50 60 70 pF1KB7 GKQVATDKVAEKLSSTLSWVKNTVSHTVSQMASQVASPSTSLHTTSSSTTLSTPALSPSS :::::::::::::::::::::::::::::: XP_016 MASQVASPSTSLHTTSSSTTLSTPALSPSS 10 20 30 80 90 100 110 120 130 pF1KB7 PSQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSSSSASSNLSHLEEDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSSSSASSNLSHLEEDS 40 50 60 70 80 90 140 150 160 170 180 190 pF1KB7 WILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQSMPIKDQYSELLKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQSMPIKDQYSELLKM 100 110 120 130 140 150 200 210 220 230 240 250 pF1KB7 TSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLL 160 170 180 190 200 210 260 270 280 290 300 310 pF1KB7 LMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSF 220 230 240 250 260 270 320 330 340 350 360 370 pF1KB7 HTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQLDMEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQLDMEG 280 290 300 310 320 330 380 390 400 410 420 430 pF1KB7 MLQHFQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIKTKEMEEQVEIKRLRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLQHFQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIKTKEMEEQVEIKRLRT 340 350 360 370 380 390 440 pF1KB7 ENRLLKQRIETLEK---------------------------------------------- :::::::::::::: XP_016 ENRLLKQRIETLEKESASLADRLIQGQVTRAQEAEENYLIKRELATIKQQSDEASAKLEQ 400 410 420 430 440 450 450 460 470 480 490 pF1KB7 --------------HKCSSNYNEDFVLQLEKELVQARLSEAESQCALKEMQDKVLDIEKR :::::::::::::::::::::::::::::::::::::::::::::: XP_016 AENTIRKLQHQQQWHKCSSNYNEDFVLQLEKELVQARLSEAESQCALKEMQDKVLDIEKR 460 470 480 490 500 510 500 510 520 530 540 550 pF1KB7 NNSLPDENNIARLQEELIAVKLREAEAIMGLKELRQQVKDLEEHWQRHLARTTGRWKDPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NNSLPDENNIARLQEELIAVKLREAEAIMGLKELRQQVKDLEEHWQRHLARTTGRWKDPP 520 530 540 550 560 570 560 570 580 590 600 610 pF1KB7 KKNAMNELQDELMTIRLREAETQAEIREIKQRMMEMETQNQINSNHLRRAEQEVISLQEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KKNAMNELQDELMTIRLREAETQAEIREIKQRMMEMETQNQINSNHLRRAEQEVISLQEK 580 590 600 610 620 630 620 630 640 650 660 670 pF1KB7 VQYLSAQNKGLLTQLSEAKRKQAEIECKNKEEVMAVRLREADSIAAVAELRQHIAELEIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VQYLSAQNKGLLTQLSEAKRKQAEIECKNKEEVMAVRLREADSIAAVAELRQHIAELEIQ 640 650 660 670 680 690 680 690 700 710 720 730 pF1KB7 KEEGKLQGQLNKSDSNQYIGELKDQIAELNHELRCLKGQRGFSGQPPFDGIHIVNHLIGD :::::::::::::::::::::::::::::::: XP_016 KEEGKLQGQLNKSDSNQYIGELKDQIAELNHESTSAQVPKRPEGLLRPTSF 700 710 720 730 740 740 750 760 770 780 790 pF1KB7 DESFHSSDEDFIDNSLQETGVGFPLHGKSGSMSLDPAVADGSESETEDSVLETRESNQVV >>XP_016857769 (OMIM: 602942) PREDICTED: ecotropic viral (826 aa) initn: 4957 init1: 2638 opt: 2754 Z-score: 1370.3 bits: 264.5 E(85289): 1.4e-69 Smith-Waterman score: 4663; 92.5% identity (92.5% similar) in 798 aa overlap (45-782:1-798) 20 30 40 50 60 70 pF1KB7 GKQVATDKVAEKLSSTLSWVKNTVSHTVSQMASQVASPSTSLHTTSSSTTLSTPALSPSS :::::::::::::::::::::::::::::: XP_016 MASQVASPSTSLHTTSSSTTLSTPALSPSS 10 20 30 80 90 100 110 120 130 pF1KB7 PSQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSSSSASSNLSHLEEDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSSSSASSNLSHLEEDS 40 50 60 70 80 90 140 150 160 170 180 190 pF1KB7 WILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQSMPIKDQYSELLKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQSMPIKDQYSELLKM 100 110 120 130 140 150 200 210 220 230 240 250 pF1KB7 TSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLL 160 170 180 190 200 210 260 270 280 290 300 310 pF1KB7 LMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSF 220 230 240 250 260 270 320 330 340 350 360 370 pF1KB7 HTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQLDMEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQLDMEG 280 290 300 310 320 330 380 390 400 410 420 430 pF1KB7 MLQHFQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIKTKEMEEQVEIKRLRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLQHFQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIKTKEMEEQVEIKRLRT 340 350 360 370 380 390 440 pF1KB7 ENRLLKQRIETLEK---------------------------------------------- :::::::::::::: XP_016 ENRLLKQRIETLEKESASLADRLIQGQVTRAQEAEENYLIKRELATIKQQSDEASAKLEQ 400 410 420 430 440 450 450 460 470 480 490 pF1KB7 --------------HKCSSNYNEDFVLQLEKELVQARLSEAESQCALKEMQDKVLDIEKR :::::::::::::::::::::::::::::::::::::::::::::: XP_016 AENTIRKLQHQQQWHKCSSNYNEDFVLQLEKELVQARLSEAESQCALKEMQDKVLDIEKR 460 470 480 490 500 510 500 510 520 530 540 550 pF1KB7 NNSLPDENNIARLQEELIAVKLREAEAIMGLKELRQQVKDLEEHWQRHLARTTGRWKDPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NNSLPDENNIARLQEELIAVKLREAEAIMGLKELRQQVKDLEEHWQRHLARTTGRWKDPP 520 530 540 550 560 570 560 570 580 590 600 610 pF1KB7 KKNAMNELQDELMTIRLREAETQAEIREIKQRMMEMETQNQINSNHLRRAEQEVISLQEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KKNAMNELQDELMTIRLREAETQAEIREIKQRMMEMETQNQINSNHLRRAEQEVISLQEK 580 590 600 610 620 630 620 630 640 650 660 670 pF1KB7 VQYLSAQNKGLLTQLSEAKRKQAEIECKNKEEVMAVRLREADSIAAVAELRQHIAELEIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VQYLSAQNKGLLTQLSEAKRKQAEIECKNKEEVMAVRLREADSIAAVAELRQHIAELEIQ 640 650 660 670 680 690 680 690 700 710 720 730 pF1KB7 KEEGKLQGQLNKSDSNQYIGELKDQIAELNHELRCLKGQRGFSGQPPFDGIHIVNHLIGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KEEGKLQGQLNKSDSNQYIGELKDQIAELNHELRCLKGQRGFSGQPPFDGIHIVNHLIGD 700 710 720 730 740 750 740 750 760 770 780 790 pF1KB7 DESFHSSDEDFIDNSLQETGVGFPLHGKSGSMSLDPAVADGSESETEDSVLETRESNQVV :::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DESFHSSDEDFIDNSLQETGVGFPLHGKSGSMSLDPAVADGSESETEDSVLETRESNQVV 760 770 780 790 800 810 800 810 pF1KB7 QKERPPRRRESYSTTV XP_016 QKERPPRRRESYSTTV 820 >>XP_016857765 (OMIM: 602942) PREDICTED: ecotropic viral (859 aa) initn: 4943 init1: 2638 opt: 2754 Z-score: 1370.1 bits: 264.5 E(85289): 1.4e-69 Smith-Waterman score: 4371; 88.3% identity (88.3% similar) in 798 aa overlap (45-749:1-798) 20 30 40 50 60 70 pF1KB7 GKQVATDKVAEKLSSTLSWVKNTVSHTVSQMASQVASPSTSLHTTSSSTTLSTPALSPSS :::::::::::::::::::::::::::::: XP_016 MASQVASPSTSLHTTSSSTTLSTPALSPSS 10 20 30 80 90 100 110 120 130 pF1KB7 PSQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSSSSASSNLSHLEEDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSSSSASSNLSHLEEDS 40 50 60 70 80 90 140 150 160 170 180 190 pF1KB7 WILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQSMPIKDQYSELLKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQSMPIKDQYSELLKM 100 110 120 130 140 150 200 210 220 230 240 250 pF1KB7 TSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLL 160 170 180 190 200 210 260 270 280 290 300 310 pF1KB7 LMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSF 220 230 240 250 260 270 320 330 340 350 360 370 pF1KB7 HTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQLDMEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQLDMEG 280 290 300 310 320 330 380 390 400 410 420 430 pF1KB7 MLQHFQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIKTKEMEEQVEIKRLRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLQHFQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIKTKEMEEQVEIKRLRT 340 350 360 370 380 390 440 pF1KB7 ENRLLKQRIETLEK---------------------------------------------- :::::::::::::: XP_016 ENRLLKQRIETLEKESASLADRLIQGQVTRAQEAEENYLIKRELATIKQQSDEASAKLEQ 400 410 420 430 440 450 450 460 470 480 490 pF1KB7 --------------HKCSSNYNEDFVLQLEKELVQARLSEAESQCALKEMQDKVLDIEKR :::::::::::::::::::::::::::::::::::::::::::::: XP_016 AENTIRKLQHQQQWHKCSSNYNEDFVLQLEKELVQARLSEAESQCALKEMQDKVLDIEKR 460 470 480 490 500 510 500 510 520 530 540 550 pF1KB7 NNSLPDENNIARLQEELIAVKLREAEAIMGLKELRQQVKDLEEHWQRHLARTTGRWKDPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NNSLPDENNIARLQEELIAVKLREAEAIMGLKELRQQVKDLEEHWQRHLARTTGRWKDPP 520 530 540 550 560 570 560 570 580 590 600 610 pF1KB7 KKNAMNELQDELMTIRLREAETQAEIREIKQRMMEMETQNQINSNHLRRAEQEVISLQEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KKNAMNELQDELMTIRLREAETQAEIREIKQRMMEMETQNQINSNHLRRAEQEVISLQEK 580 590 600 610 620 630 620 630 640 650 660 670 pF1KB7 VQYLSAQNKGLLTQLSEAKRKQAEIECKNKEEVMAVRLREADSIAAVAELRQHIAELEIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VQYLSAQNKGLLTQLSEAKRKQAEIECKNKEEVMAVRLREADSIAAVAELRQHIAELEIQ 640 650 660 670 680 690 680 690 700 pF1KB7 KEEGKLQGQLNKSDSNQYIGELKDQIAELNHE---------------------------- :::::::::::::::::::::::::::::::: XP_016 KEEGKLQGQLNKSDSNQYIGELKDQIAELNHEGELGREGRNVIPDWHSPHAEGNLMSGKQ 700 710 720 730 740 750 710 720 730 740 750 760 pF1KB7 -----LRCLKGQRGFSGQPPFDGIHIVNHLIGDDESFHSSDEDFIDNSLQETGVGFPLHG ::::::::::::::::::::::::::::::::::::::::::: XP_016 HSSPTLRCLKGQRGFSGQPPFDGIHIVNHLIGDDESFHSSDEDFIDNSLQETGVGFPLHG 760 770 780 790 800 810 770 780 790 800 810 pF1KB7 KSGSMSLDPAVADGSESETEDSVLETRESNQVVQKERPPRRRESYSTTV XP_016 KSGSMSLDPAVADGSESETEDSVLETRESNQVVQKERPPRRRESYSTTV 820 830 840 850 >-- initn: 390 init1: 390 opt: 390 Z-score: 216.0 bits: 51.0 E(85289): 2.7e-05 Smith-Waterman score: 390; 100.0% identity (100.0% similar) in 61 aa overlap (750-810:799-859) 720 730 740 750 760 770 pF1KB7 PPFDGIHIVNHLIGDDESFHSSDEDFIDNSLQETGVGFPLHGKSGSMSLDPAVADGSESE :::::::::::::::::::::::::::::: XP_016 PPFDGIHIVNHLIGDDESFHSSDEDFIDNSLQETGVGFPLHGKSGSMSLDPAVADGSESE 770 780 790 800 810 820 780 790 800 810 pF1KB7 TEDSVLETRESNQVVQKERPPRRRESYSTTV ::::::::::::::::::::::::::::::: XP_016 TEDSVLETRESNQVVQKERPPRRRESYSTTV 830 840 850 >>XP_016857773 (OMIM: 602942) PREDICTED: ecotropic viral (777 aa) initn: 2804 init1: 2638 opt: 2690 Z-score: 1339.4 bits: 258.7 E(85289): 7.3e-68 Smith-Waterman score: 4935; 98.6% identity (98.6% similar) in 777 aa overlap (45-810:1-777) 20 30 40 50 60 70 pF1KB7 GKQVATDKVAEKLSSTLSWVKNTVSHTVSQMASQVASPSTSLHTTSSSTTLSTPALSPSS :::::::::::::::::::::::::::::: XP_016 MASQVASPSTSLHTTSSSTTLSTPALSPSS 10 20 30 80 90 100 110 120 130 pF1KB7 PSQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSSSSASSNLSHLEEDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PSQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSSSSASSNLSHLEEDS 40 50 60 70 80 90 140 150 160 170 180 190 pF1KB7 WILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQSMPIKDQYSELLKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQSMPIKDQYSELLKM 100 110 120 130 140 150 200 210 220 230 240 250 pF1KB7 TSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLL 160 170 180 190 200 210 260 270 280 290 300 310 pF1KB7 LMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSF 220 230 240 250 260 270 320 330 340 350 360 370 pF1KB7 HTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQLDMEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQLDMEG 280 290 300 310 320 330 380 390 400 410 420 430 pF1KB7 MLQHFQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIKTKEMEEQVEIKRLRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLQHFQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIKTKEMEEQVEIKRLRT 340 350 360 370 380 390 440 450 460 470 480 pF1KB7 ENRLLKQRIETLEK-----------HKCSSNYNEDFVLQLEKELVQARLSEAESQCALKE :::::::::::::: ::::::::::::::::::::::::::::::::::: XP_016 ENRLLKQRIETLEKESASLADRLIQHKCSSNYNEDFVLQLEKELVQARLSEAESQCALKE 400 410 420 430 440 450 490 500 510 520 530 540 pF1KB7 MQDKVLDIEKRNNSLPDENNIARLQEELIAVKLREAEAIMGLKELRQQVKDLEEHWQRHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MQDKVLDIEKRNNSLPDENNIARLQEELIAVKLREAEAIMGLKELRQQVKDLEEHWQRHL 460 470 480 490 500 510 550 560 570 580 590 600 pF1KB7 ARTTGRWKDPPKKNAMNELQDELMTIRLREAETQAEIREIKQRMMEMETQNQINSNHLRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ARTTGRWKDPPKKNAMNELQDELMTIRLREAETQAEIREIKQRMMEMETQNQINSNHLRR 520 530 540 550 560 570 610 620 630 640 650 660 pF1KB7 AEQEVISLQEKVQYLSAQNKGLLTQLSEAKRKQAEIECKNKEEVMAVRLREADSIAAVAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AEQEVISLQEKVQYLSAQNKGLLTQLSEAKRKQAEIECKNKEEVMAVRLREADSIAAVAE 580 590 600 610 620 630 670 680 690 700 710 720 pF1KB7 LRQHIAELEIQKEEGKLQGQLNKSDSNQYIGELKDQIAELNHELRCLKGQRGFSGQPPFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LRQHIAELEIQKEEGKLQGQLNKSDSNQYIGELKDQIAELNHELRCLKGQRGFSGQPPFD 640 650 660 670 680 690 730 740 750 760 770 780 pF1KB7 GIHIVNHLIGDDESFHSSDEDFIDNSLQETGVGFPLHGKSGSMSLDPAVADGSESETEDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GIHIVNHLIGDDESFHSSDEDFIDNSLQETGVGFPLHGKSGSMSLDPAVADGSESETEDS 700 710 720 730 740 750 790 800 810 pF1KB7 VLETRESNQVVQKERPPRRRESYSTTV ::::::::::::::::::::::::::: XP_016 VLETRESNQVVQKERPPRRRESYSTTV 760 770 810 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 22:15:46 2016 done: Sat Nov 5 22:15:48 2016 Total Scan time: 13.520 Total Display time: 0.280 Function used was FASTA [36.3.4 Apr, 2011]