FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB7312, 1059 aa 1>>>pF1KB7312 1059 - 1059 aa - 1059 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.4826+/-0.000401; mu= 12.4100+/- 0.025 mean_var=155.0371+/-31.449, 0's: 0 Z-trim(117.4): 318 B-trim: 53 in 1/56 Lambda= 0.103005 statistics sampled from 28955 (29301) to 28955 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.669), E-opt: 0.2 (0.344), width: 16 Scan time: 15.580 The best scores are: opt bits E(85289) NP_892018 (OMIM: 610477) transmembrane protease se (1059) 7308 1098.9 0 XP_011526280 (OMIM: 610477) PREDICTED: transmembra (1093) 6735 1013.7 0 XP_011526282 (OMIM: 610477) PREDICTED: transmembra ( 690) 4805 726.8 1e-208 XP_011526284 (OMIM: 610477) PREDICTED: transmembra ( 562) 3912 594.0 7.8e-169 NP_001275930 (OMIM: 206200,609862) transmembrane p ( 802) 843 138.1 2e-31 NP_705837 (OMIM: 206200,609862) transmembrane prot ( 811) 843 138.1 2e-31 NP_068813 (OMIM: 606797) suppressor of tumorigenic ( 855) 810 133.2 6.3e-30 NP_001275679 (OMIM: 606751) transmembrane protease ( 413) 766 126.4 3.3e-28 NP_001275680 (OMIM: 606751) transmembrane protease ( 448) 766 126.4 3.5e-28 NP_110397 (OMIM: 606751) transmembrane protease se ( 457) 766 126.4 3.6e-28 XP_011527961 (OMIM: 226200,606635) PREDICTED: ente (1034) 693 115.9 1.2e-24 XP_011527960 (OMIM: 226200,606635) PREDICTED: ente (1037) 693 115.9 1.2e-24 XP_011527959 (OMIM: 226200,606635) PREDICTED: ente (1049) 693 115.9 1.3e-24 NP_001193718 (OMIM: 610050) transmembrane protease ( 532) 687 114.7 1.4e-24 NP_001070731 (OMIM: 610050) transmembrane protease ( 567) 687 114.8 1.4e-24 NP_001231924 (OMIM: 610050) transmembrane protease ( 563) 685 114.5 1.8e-24 XP_011528035 (OMIM: 602060) PREDICTED: transmembra ( 384) 677 113.2 3e-24 XP_005261100 (OMIM: 602060) PREDICTED: transmembra ( 452) 677 113.2 3.4e-24 XP_011528033 (OMIM: 602060) PREDICTED: transmembra ( 492) 677 113.2 3.6e-24 NP_005647 (OMIM: 602060) transmembrane protease se ( 492) 677 113.2 3.6e-24 NP_002763 (OMIM: 226200,606635) enteropeptidase pr (1019) 682 114.2 3.8e-24 NP_001128571 (OMIM: 602060) transmembrane protease ( 529) 677 113.3 3.8e-24 XP_011527956 (OMIM: 226200,606635) PREDICTED: ente (1064) 682 114.2 3.9e-24 XP_011527958 (OMIM: 226200,606635) PREDICTED: ente (1064) 682 114.2 3.9e-24 XP_011527957 (OMIM: 226200,606635) PREDICTED: ente (1064) 682 114.2 3.9e-24 XP_005255530 (OMIM: 609343) PREDICTED: brain-speci ( 317) 670 112.0 5.3e-24 NP_071402 (OMIM: 609343) brain-specific serine pro ( 317) 670 112.0 5.3e-24 XP_016863673 (OMIM: 229000,612423) PREDICTED: plas ( 436) 671 112.3 6.2e-24 NP_001305325 (OMIM: 229000,612423) plasma kallikre ( 436) 671 112.3 6.2e-24 NP_000883 (OMIM: 229000,612423) plasma kallikrein ( 638) 671 112.4 8.2e-24 XP_011530232 (OMIM: 229000,612423) PREDICTED: plas ( 649) 671 112.4 8.4e-24 XP_016863670 (OMIM: 229000,612423) PREDICTED: plas ( 649) 671 112.4 8.4e-24 NP_001265514 (OMIM: 605236,614595) atrial natriure ( 938) 671 112.6 1.1e-23 NP_001243246 (OMIM: 605511) transmembrane protease ( 453) 665 111.4 1.2e-23 NP_006578 (OMIM: 605236,614595) atrial natriuretic (1042) 671 112.6 1.2e-23 XP_005265767 (OMIM: 605369) PREDICTED: transmembra ( 301) 660 110.5 1.4e-23 NP_659205 (OMIM: 608159) testisin isoform 2 prepro ( 312) 659 110.4 1.6e-23 NP_004253 (OMIM: 605369) transmembrane protease se ( 418) 660 110.7 1.8e-23 NP_115780 (OMIM: 605511) transmembrane protease se ( 327) 653 109.5 3.1e-23 NP_076927 (OMIM: 605511) transmembrane protease se ( 454) 653 109.6 4.1e-23 XP_011530198 (OMIM: 610399) PREDICTED: transmembra ( 345) 648 108.8 5.5e-23 NP_054777 (OMIM: 610399) transmembrane protease se ( 423) 648 108.9 6.4e-23 XP_016864340 (OMIM: 605369) PREDICTED: transmembra ( 234) 641 107.6 8.4e-23 NP_036599 (OMIM: 609341) tryptase gamma preproprot ( 321) 637 107.1 1.6e-22 NP_001277025 (OMIM: 606565) transmembrane protease ( 290) 631 106.2 2.8e-22 NP_001167023 (OMIM: 606565) transmembrane protease ( 397) 631 106.3 3.5e-22 NP_001277023 (OMIM: 606565) transmembrane protease ( 412) 631 106.3 3.6e-22 NP_001077416 (OMIM: 606565) transmembrane protease ( 432) 631 106.4 3.8e-22 NP_001167022 (OMIM: 606565) transmembrane protease ( 435) 631 106.4 3.8e-22 NP_063947 (OMIM: 606565) transmembrane protease se ( 437) 631 106.4 3.8e-22 >>NP_892018 (OMIM: 610477) transmembrane protease serine (1059 aa) initn: 7308 init1: 7308 opt: 7308 Z-score: 5875.7 bits: 1098.9 E(85289): 0 Smith-Waterman score: 7308; 100.0% identity (100.0% similar) in 1059 aa overlap (1-1059:1-1059) 10 20 30 40 50 60 pF1KB7 MEPTVADVHLVPRTTKEVPALDAACCRAASIGVVATSLVVLTLGVLLAFLSTQGFHVDHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 MEPTVADVHLVPRTTKEVPALDAACCRAASIGVVATSLVVLTLGVLLAFLSTQGFHVDHT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB7 AELRGIRWTSSLRRETSDYHRTLTPTLEALLHFLLRPLQTLSLGLEEELLQRGIRARLRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 AELRGIRWTSSLRRETSDYHRTLTPTLEALLHFLLRPLQTLSLGLEEELLQRGIRARLRE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB7 HGISLAAYGTIVSAELTGRHKGPLAERDFKSGRCPGNSFSCGNSQCVTKVNPECDDQEDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 HGISLAAYGTIVSAELTGRHKGPLAERDFKSGRCPGNSFSCGNSQCVTKVNPECDDQEDC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB7 SDGSDEAHCECGLQPAWRMAGRIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 SDGSDEAHCECGLQPAWRMAGRIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB7 AAHCFNEFQDPTKWVAYVGATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 AAHCFNEFQDPTKWVAYVGATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB7 PLPFGRHIQPVCLPAATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 PLPFGRHIQPVCLPAATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCAS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB7 LYGHSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 LYGHSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB7 YARVTRLRDWILEATTKASMPLAPTMAPAPAAPSTAWPTSPESPVVSTPTKSMQALSTVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 YARVTRLRDWILEATTKASMPLAPTMAPAPAAPSTAWPTSPESPVVSTPTKSMQALSTVP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB7 LDWVTVPKLQECGARPAMEKPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 LDWVTVPKLQECGARPAMEKPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB7 SAAHCFNHTKVEQVRAHLGTASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 SAAHCFNHTKVEQVRAHLGTASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELAS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB7 PLAFNKYIQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 PLAFNKYIQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSV 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB7 LYNFSLTDRMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 LYNFSLTDRMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGV 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB7 YTRITRLKGWILEIMSSQPLPMSPPSTTRMLATTSPRTTAGLTVPGATPSRPTPGAASRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 YTRITRLKGWILEIMSSQPLPMSPPSTTRMLATTSPRTTAGLTVPGATPSRPTPGAASRV 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB7 TGQPANSTLSAVSTTARGQTPFPDAPEATTHTQLPDCGLAPAALTRIVGGSAAGRGEWPW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 TGQPANSTLSAVSTTARGQTPFPDAPEATTHTQLPDCGLAPAALTRIVGGSAAGRGEWPW 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB7 QVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGDPKQWAAFLGTPFLSGAEGQLERVAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 QVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGDPKQWAAFLGTPFLSGAEGQLERVAR 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB7 IYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPICLPEPAPRPPDGTRCVITGWGSVREG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 IYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPICLPEPAPRPPDGTRCVITGWGSVREG 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KB7 GSMARQLQKAAVRLLSEQTCRRFYPVQISSRMLCAGFPQGGVDSCSGDAGGPLACREPSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 GSMARQLQKAAVRLLSEQTCRRFYPVQISSRMLCAGFPQGGVDSCSGDAGGPLACREPSG 970 980 990 1000 1010 1020 1030 1040 1050 pF1KB7 RWVLTGVTSWGYGCGRPHFPGVYTRVAAVRGWIGQHIQE ::::::::::::::::::::::::::::::::::::::: NP_892 RWVLTGVTSWGYGCGRPHFPGVYTRVAAVRGWIGQHIQE 1030 1040 1050 >>XP_011526280 (OMIM: 610477) PREDICTED: transmembrane p (1093 aa) initn: 6735 init1: 6735 opt: 6735 Z-score: 5415.4 bits: 1013.7 E(85289): 0 Smith-Waterman score: 7217; 96.9% identity (96.9% similar) in 1091 aa overlap (3-1059:3-1093) 10 20 30 40 50 60 pF1KB7 MEPTVADVHLVPRTTKEVPALDAACCRAASIGVVATSLVVLTLGVLLAFLSTQGFHVDHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MEPTVADVHLVPRTTKEVPALDAACCRAASIGVVATSLVVLTLGVLLAFLSTQGFHVDHT 10 20 30 40 50 60 70 80 90 pF1KB7 AELRGIRWTSSLRRETSDYHRTLTPTLEAL------------------------------ :::::::::::::::::::::::::::::: XP_011 AELRGIRWTSSLRRETSDYHRTLTPTLEALFVSSFQKTELEASCVGCSVLNYRDGNSSVL 70 80 90 100 110 120 100 110 120 130 140 pF1KB7 ----LHFLLRPLQTLSLGLEEELLQRGIRARLREHGISLAAYGTIVSAELTGRHKGPLAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VHFQLHFLLRPLQTLSLGLEEELLQRGIRARLREHGISLAAYGTIVSAELTGRHKGPLAE 130 140 150 160 170 180 150 160 170 180 190 200 pF1KB7 RDFKSGRCPGNSFSCGNSQCVTKVNPECDDQEDCSDGSDEAHCECGLQPAWRMAGRIVGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RDFKSGRCPGNSFSCGNSQCVTKVNPECDDQEDCSDGSDEAHCECGLQPAWRMAGRIVGG 190 200 210 220 230 240 210 220 230 240 250 260 pF1KB7 MEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCFNEFQDPTKWVAYVGATYLSGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCFNEFQDPTKWVAYVGATYLSGS 250 260 270 280 290 300 270 280 290 300 310 320 pF1KB7 EASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRHIQPVCLPAATHIFPPSKKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRHIQPVCLPAATHIFPPSKKC 310 320 330 340 350 360 330 340 350 360 370 380 pF1KB7 LISGWGYLKEDFLVKPEVLQKATVELLDQALCASLYGHSLTDRMVCAGYLDGKVDSCQGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LISGWGYLKEDFLVKPEVLQKATVELLDQALCASLYGHSLTDRMVCAGYLDGKVDSCQGD 370 380 390 400 410 420 390 400 410 420 430 440 pF1KB7 SGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVTRLRDWILEATTKASMPLAPTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVTRLRDWILEATTKASMPLAPTM 430 440 450 460 470 480 450 460 470 480 490 500 pF1KB7 APAPAAPSTAWPTSPESPVVSTPTKSMQALSTVPLDWVTVPKLQECGARPAMEKPTRVVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 APAPAAPSTAWPTSPESPVVSTPTKSMQALSTVPLDWVTVPKLQECGARPAMEKPTRVVG 490 500 510 520 530 540 510 520 530 540 550 560 pF1KB7 GFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCFNHTKVEQVRAHLGTASLLGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCFNHTKVEQVRAHLGTASLLGL 550 560 570 580 590 600 570 580 590 600 610 620 pF1KB7 GGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPLAFNKYIQPVCLPLAIQKFPVGRKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPLAFNKYIQPVCLPLAIQKFPVGRKC 610 620 630 640 650 660 630 640 650 660 670 680 pF1KB7 MISGWGNTQEGNATKPELLQKASVGIIDQKTCSVLYNFSLTDRMICAGFLEGKVDSCQGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MISGWGNTQEGNATKPELLQKASVGIIDQKTCSVLYNFSLTDRMICAGFLEGKVDSCQGD 670 680 690 700 710 720 690 700 710 720 730 740 pF1KB7 SGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGVYTRITRLKGWILEIMSSQPLPMSPPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGVYTRITRLKGWILEIMSSQPLPMSPPS 730 740 750 760 770 780 750 760 770 780 790 800 pF1KB7 TTRMLATTSPRTTAGLTVPGATPSRPTPGAASRVTGQPANSTLSAVSTTARGQTPFPDAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TTRMLATTSPRTTAGLTVPGATPSRPTPGAASRVTGQPANSTLSAVSTTARGQTPFPDAP 790 800 810 820 830 840 810 820 830 840 850 860 pF1KB7 EATTHTQLPDCGLAPAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EATTHTQLPDCGLAPAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSA 850 860 870 880 890 900 870 880 890 900 910 920 pF1KB7 AHCFDVYGDPKQWAAFLGTPFLSGAEGQLERVARIYKHPFYNLYTLDYDVALLELAGPVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AHCFDVYGDPKQWAAFLGTPFLSGAEGQLERVARIYKHPFYNLYTLDYDVALLELAGPVR 910 920 930 940 950 960 930 940 950 960 970 980 pF1KB7 RSRLVRPICLPEPAPRPPDGTRCVITGWGSVREGGSMARQLQKAAVRLLSEQTCRRFYPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSRLVRPICLPEPAPRPPDGTRCVITGWGSVREGGSMARQLQKAAVRLLSEQTCRRFYPV 970 980 990 1000 1010 1020 990 1000 1010 1020 1030 1040 pF1KB7 QISSRMLCAGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QISSRMLCAGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRV 1030 1040 1050 1060 1070 1080 1050 pF1KB7 AAVRGWIGQHIQE ::::::::::::: XP_011 AAVRGWIGQHIQE 1090 >>XP_011526282 (OMIM: 610477) PREDICTED: transmembrane p (690 aa) initn: 4805 init1: 4805 opt: 4805 Z-score: 3868.1 bits: 726.8 E(85289): 1e-208 Smith-Waterman score: 4805; 100.0% identity (100.0% similar) in 690 aa overlap (370-1059:1-690) 340 350 360 370 380 390 pF1KB7 VKPEVLQKATVELLDQALCASLYGHSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGR :::::::::::::::::::::::::::::: XP_011 MVCAGYLDGKVDSCQGDSGGPLVCEEPSGR 10 20 30 400 410 420 430 440 450 pF1KB7 FFLAGIVSWGIGCAEARRPGVYARVTRLRDWILEATTKASMPLAPTMAPAPAAPSTAWPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FFLAGIVSWGIGCAEARRPGVYARVTRLRDWILEATTKASMPLAPTMAPAPAAPSTAWPT 40 50 60 70 80 90 460 470 480 490 500 510 pF1KB7 SPESPVVSTPTKSMQALSTVPLDWVTVPKLQECGARPAMEKPTRVVGGFGAASGEVPWQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPESPVVSTPTKSMQALSTVPLDWVTVPKLQECGARPAMEKPTRVVGGFGAASGEVPWQV 100 110 120 130 140 150 520 530 540 550 560 570 pF1KB7 SLKEGSRHFCGATVVGDRWLLSAAHCFNHTKVEQVRAHLGTASLLGLGGSPVKIGLRRVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SLKEGSRHFCGATVVGDRWLLSAAHCFNHTKVEQVRAHLGTASLLGLGGSPVKIGLRRVV 160 170 180 190 200 210 580 590 600 610 620 630 pF1KB7 LHPLYNPGILDFDLAVLELASPLAFNKYIQPVCLPLAIQKFPVGRKCMISGWGNTQEGNA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LHPLYNPGILDFDLAVLELASPLAFNKYIQPVCLPLAIQKFPVGRKCMISGWGNTQEGNA 220 230 240 250 260 270 640 650 660 670 680 690 pF1KB7 TKPELLQKASVGIIDQKTCSVLYNFSLTDRMICAGFLEGKVDSCQGDSGGPLACEEAPGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TKPELLQKASVGIIDQKTCSVLYNFSLTDRMICAGFLEGKVDSCQGDSGGPLACEEAPGV 280 290 300 310 320 330 700 710 720 730 740 750 pF1KB7 FYLAGIVSWGIGCAQVKKPGVYTRITRLKGWILEIMSSQPLPMSPPSTTRMLATTSPRTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FYLAGIVSWGIGCAQVKKPGVYTRITRLKGWILEIMSSQPLPMSPPSTTRMLATTSPRTT 340 350 360 370 380 390 760 770 780 790 800 810 pF1KB7 AGLTVPGATPSRPTPGAASRVTGQPANSTLSAVSTTARGQTPFPDAPEATTHTQLPDCGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AGLTVPGATPSRPTPGAASRVTGQPANSTLSAVSTTARGQTPFPDAPEATTHTQLPDCGL 400 410 420 430 440 450 820 830 840 850 860 870 pF1KB7 APAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGDPKQW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 APAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGDPKQW 460 470 480 490 500 510 880 890 900 910 920 930 pF1KB7 AAFLGTPFLSGAEGQLERVARIYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPICLPEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AAFLGTPFLSGAEGQLERVARIYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPICLPEP 520 530 540 550 560 570 940 950 960 970 980 990 pF1KB7 APRPPDGTRCVITGWGSVREGGSMARQLQKAAVRLLSEQTCRRFYPVQISSRMLCAGFPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 APRPPDGTRCVITGWGSVREGGSMARQLQKAAVRLLSEQTCRRFYPVQISSRMLCAGFPQ 580 590 600 610 620 630 1000 1010 1020 1030 1040 1050 pF1KB7 GGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVAAVRGWIGQHIQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVAAVRGWIGQHIQE 640 650 660 670 680 690 >>XP_011526284 (OMIM: 610477) PREDICTED: transmembrane p (562 aa) initn: 3912 init1: 3912 opt: 3912 Z-score: 3152.1 bits: 594.0 E(85289): 7.8e-169 Smith-Waterman score: 3912; 100.0% identity (100.0% similar) in 562 aa overlap (498-1059:1-562) 470 480 490 500 510 520 pF1KB7 TPTKSMQALSTVPLDWVTVPKLQECGARPAMEKPTRVVGGFGAASGEVPWQVSLKEGSRH :::::::::::::::::::::::::::::: XP_011 MEKPTRVVGGFGAASGEVPWQVSLKEGSRH 10 20 30 530 540 550 560 570 580 pF1KB7 FCGATVVGDRWLLSAAHCFNHTKVEQVRAHLGTASLLGLGGSPVKIGLRRVVLHPLYNPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FCGATVVGDRWLLSAAHCFNHTKVEQVRAHLGTASLLGLGGSPVKIGLRRVVLHPLYNPG 40 50 60 70 80 90 590 600 610 620 630 640 pF1KB7 ILDFDLAVLELASPLAFNKYIQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ILDFDLAVLELASPLAFNKYIQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQK 100 110 120 130 140 150 650 660 670 680 690 700 pF1KB7 ASVGIIDQKTCSVLYNFSLTDRMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ASVGIIDQKTCSVLYNFSLTDRMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVS 160 170 180 190 200 210 710 720 730 740 750 760 pF1KB7 WGIGCAQVKKPGVYTRITRLKGWILEIMSSQPLPMSPPSTTRMLATTSPRTTAGLTVPGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 WGIGCAQVKKPGVYTRITRLKGWILEIMSSQPLPMSPPSTTRMLATTSPRTTAGLTVPGA 220 230 240 250 260 270 770 780 790 800 810 820 pF1KB7 TPSRPTPGAASRVTGQPANSTLSAVSTTARGQTPFPDAPEATTHTQLPDCGLAPAALTRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TPSRPTPGAASRVTGQPANSTLSAVSTTARGQTPFPDAPEATTHTQLPDCGLAPAALTRI 280 290 300 310 320 330 830 840 850 860 870 880 pF1KB7 VGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGDPKQWAAFLGTPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGDPKQWAAFLGTPF 340 350 360 370 380 390 890 900 910 920 930 940 pF1KB7 LSGAEGQLERVARIYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPICLPEPAPRPPDGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LSGAEGQLERVARIYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPICLPEPAPRPPDGT 400 410 420 430 440 450 950 960 970 980 990 1000 pF1KB7 RCVITGWGSVREGGSMARQLQKAAVRLLSEQTCRRFYPVQISSRMLCAGFPQGGVDSCSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RCVITGWGSVREGGSMARQLQKAAVRLLSEQTCRRFYPVQISSRMLCAGFPQGGVDSCSG 460 470 480 490 500 510 1010 1020 1030 1040 1050 pF1KB7 DAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVAAVRGWIGQHIQE :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVAAVRGWIGQHIQE 520 530 540 550 560 >>NP_001275930 (OMIM: 206200,609862) transmembrane prote (802 aa) initn: 1275 init1: 588 opt: 843 Z-score: 685.2 bits: 138.1 E(85289): 2e-31 Smith-Waterman score: 958; 46.0% identity (73.7% similar) in 285 aa overlap (154-436:522-802) 130 140 150 160 170 180 pF1KB7 SLAAYGTIVSAELTGRHKGPLAERDFKSGRCPGNSFSCGNSQCVTKVNPECDDQEDCSDG : .:.: . .:: : ::.:: . :: :: NP_001 STCISLPKVCDGQPDCLNGSDEEQCQEGVPCGTFTFQCEDRSCVKKPNPQCDGRPDCRDG 500 510 520 530 540 550 190 200 210 220 230 240 pF1KB7 SDEAHCECGLQPAWRMAGRIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAH ::: ::.:::: ..::::: .: ::.::::::. .:.::.:.: ::...::: NP_001 SDEEHCDCGLQGP---SSRIVGGAVSSEGEWPWQASLQVRGRHICGGALIADRWVITAAH 560 570 580 590 600 250 260 270 280 290 300 pF1KB7 CFNE--FQDPTKWVAYVGATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSP ::.: . . . :....: .. .. . : .: ... :: .. :. :.:::.:.: : NP_001 CFQEDSMASTVLWTVFLGKVWQNSRWPGEVSFKVSRLLLHPYHEEDSHDYDVALLQLDHP 610 620 630 640 650 660 310 320 330 340 350 360 pF1KB7 LPFGRHIQPVCLPAATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCASL . . ..:::::: .:.: :. .: :.::: :.: .. ..:::. :.:. : ::. . NP_001 VVRSAAVRPVCLPARSHFFEPGLHCWITGWGALREGGPIS-NALQKVDVQLIPQDLCSEV 670 680 690 700 710 720 370 380 390 400 410 420 pF1KB7 YGHSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVY : ...: ::.:::: :: :.:::::::::::. :::.::::.::::.::.. ::: NP_001 YRYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGLVSWGLGCGRPNYFGVY 730 740 750 760 770 780 430 440 450 460 470 480 pF1KB7 ARVTRLRDWILEATTKASMPLAPTMAPAPAAPSTAWPTSPESPVVSTPTKSMQALSTVPL .:.: . .:: ...: NP_001 TRITGVISWIQQVVT 790 800 >>NP_705837 (OMIM: 206200,609862) transmembrane protease (811 aa) initn: 1275 init1: 588 opt: 843 Z-score: 685.1 bits: 138.1 E(85289): 2e-31 Smith-Waterman score: 958; 46.0% identity (73.7% similar) in 285 aa overlap (154-436:531-811) 130 140 150 160 170 180 pF1KB7 SLAAYGTIVSAELTGRHKGPLAERDFKSGRCPGNSFSCGNSQCVTKVNPECDDQEDCSDG : .:.: . .:: : ::.:: . :: :: NP_705 STCISLPKVCDGQPDCLNGSDEEQCQEGVPCGTFTFQCEDRSCVKKPNPQCDGRPDCRDG 510 520 530 540 550 560 190 200 210 220 230 240 pF1KB7 SDEAHCECGLQPAWRMAGRIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAH ::: ::.:::: ..::::: .: ::.::::::. .:.::.:.: ::...::: NP_705 SDEEHCDCGLQGP---SSRIVGGAVSSEGEWPWQASLQVRGRHICGGALIADRWVITAAH 570 580 590 600 610 250 260 270 280 290 300 pF1KB7 CFNE--FQDPTKWVAYVGATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSP ::.: . . . :....: .. .. . : .: ... :: .. :. :.:::.:.: : NP_705 CFQEDSMASTVLWTVFLGKVWQNSRWPGEVSFKVSRLLLHPYHEEDSHDYDVALLQLDHP 620 630 640 650 660 670 310 320 330 340 350 360 pF1KB7 LPFGRHIQPVCLPAATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCASL . . ..:::::: .:.: :. .: :.::: :.: .. ..:::. :.:. : ::. . NP_705 VVRSAAVRPVCLPARSHFFEPGLHCWITGWGALREGGPIS-NALQKVDVQLIPQDLCSEV 680 690 700 710 720 730 370 380 390 400 410 420 pF1KB7 YGHSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVY : ...: ::.:::: :: :.:::::::::::. :::.::::.::::.::.. ::: NP_705 YRYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGLVSWGLGCGRPNYFGVY 740 750 760 770 780 790 430 440 450 460 470 480 pF1KB7 ARVTRLRDWILEATTKASMPLAPTMAPAPAAPSTAWPTSPESPVVSTPTKSMQALSTVPL .:.: . .:: ...: NP_705 TRITGVISWIQQVVT 800 810 >>NP_068813 (OMIM: 606797) suppressor of tumorigenicity (855 aa) initn: 1562 init1: 570 opt: 810 Z-score: 658.3 bits: 133.2 E(85289): 6.3e-30 Smith-Waterman score: 972; 45.7% identity (73.0% similar) in 289 aa overlap (154-435:567-853) 130 140 150 160 170 180 pF1KB7 SLAAYGTIVSAELTGRHKGPLAERDFKSGRCPGNSFSCGNSQCVTKVNPECDDQEDCSDG : ... : :. :..: ::::: .:::::: NP_068 CLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDG 540 550 560 570 580 590 190 200 210 220 230 240 pF1KB7 SDEAHCECGLQPAWRMAGRIVGGMEASPGEFPWQASLRE-NKEHFCGAAIINARWLVSAA ::: :.:::. :.: :.::: .:. ::.:::.::. .. :.:::..:. :::::: NP_068 SDEKDCDCGLRSFTRQA-RVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAA 600 610 620 630 640 650 250 260 270 280 290 pF1KB7 HCFNE-----FQDPTKWVAYVGATYLSGSEASTVRAQVVQ-IVKHPLYNADTADFDVAVL ::. . ..:::.:.:..: : : :. . .. :..::..: : :.:.:.: NP_068 HCYIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALL 660 670 680 690 700 710 300 310 320 330 340 350 pF1KB7 ELTSPLPFGRHIQPVCLPAATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQA :: .: .. ..:.::: :.:.:: .: ..:::. . . .:::. .....:. NP_068 ELEKPAEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGG-TGALILQKGEIRVINQT 720 730 740 750 760 770 360 370 380 390 400 410 pF1KB7 LCASLYGHSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEAR : .: ...: ::.:.:.:.: :::::::::::: : .::.: ::.:::: :::. NP_068 TCENLLPQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRN 780 790 800 810 820 830 420 430 440 450 460 470 pF1KB7 RPGVYARVTRLRDWILEATTKASMPLAPTMAPAPAAPSTAWPTSPESPVVSTPTKSMQAL .::::.:. .:::: : : NP_068 KPGVYTRLPLFRDWIKENTGV 840 850 >>NP_001275679 (OMIM: 606751) transmembrane protease ser (413 aa) initn: 848 init1: 230 opt: 766 Z-score: 627.4 bits: 126.4 E(85289): 3.3e-28 Smith-Waterman score: 766; 43.5% identity (73.3% similar) in 262 aa overlap (177-431:149-404) 150 160 170 180 190 200 pF1KB7 RDFKSGRCPGNSFSCGNSQCVTKVNPECDDQEDCSDGSDEA-HC-ECGLQPAWRMAGRIV ...:..:. . .: ::: .: .:.::: NP_001 NLTDIKLNSSQEFAQLSPRLGGFLEEAWQPRNNCTSGQVVSLRCSECGARP---LASRIV 120 130 140 150 160 170 210 220 230 240 250 260 pF1KB7 GGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCFNEFQDP--TKWVAYVGATY ::. ..::..:::::. . .: ::.... ::.:.::::.. :. ..: ...: . NP_001 GGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAGLVS 180 190 200 210 220 230 270 280 290 300 310 320 pF1KB7 LSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRHIQPVCLPAATHIFPP :. . : : .:. ::::.:.. :.:::.:.: . : :. . ::::: . :: NP_001 HSAVRPHQ-GALVERIIPHPLYSAQNHDYDVALLRLQTALNFSDTVGAVCLPAKEQHFPK 240 250 260 270 280 290 330 340 350 360 370 380 pF1KB7 SKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCAS--LYGHSLTDRMVCAGYLDGKV ...: .::::. . . . ..:: ..: :.. :: : .:. .:: ::.:::::::.. NP_001 GSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYLDGRA 300 310 320 330 340 350 390 400 410 420 430 pF1KB7 DSCQGDSGGPLVCEEPSGRFF-LAGIVSWGIGCAEARRPGVYARVTRLRDWILEATTKAS :.::::::::::: :.: . :.:.:::: :::: .:::::.:... ::: NP_001 DACQGDSGGPLVC--PDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAEFLDWIHDTAQDSL 360 370 380 390 400 410 440 450 460 470 480 490 pF1KB7 MPLAPTMAPAPAAPSTAWPTSPESPVVSTPTKSMQALSTVPLDWVTVPKLQECGARPAME NP_001 L >>NP_001275680 (OMIM: 606751) transmembrane protease ser (448 aa) initn: 870 init1: 230 opt: 766 Z-score: 626.9 bits: 126.4 E(85289): 3.5e-28 Smith-Waterman score: 766; 43.5% identity (73.3% similar) in 262 aa overlap (177-431:184-439) 150 160 170 180 190 200 pF1KB7 RDFKSGRCPGNSFSCGNSQCVTKVNPECDDQEDCSDGSDEA-HC-ECGLQPAWRMAGRIV ...:..:. . .: ::: .: .:.::: NP_001 NLTDIKLNSSQEFAQLSPRLGGFLEEAWQPRNNCTSGQVVSLRCSECGARP---LASRIV 160 170 180 190 200 210 210 220 230 240 250 260 pF1KB7 GGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCFNEFQDP--TKWVAYVGATY ::. ..::..:::::. . .: ::.... ::.:.::::.. :. ..: ...: . NP_001 GGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAGLVS 220 230 240 250 260 270 270 280 290 300 310 320 pF1KB7 LSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRHIQPVCLPAATHIFPP :. . : : .:. ::::.:.. :.:::.:.: . : :. . ::::: . :: NP_001 HSAVRPHQ-GALVERIIPHPLYSAQNHDYDVALLRLQTALNFSDTVGAVCLPAKEQHFPK 280 290 300 310 320 330 340 350 360 370 380 pF1KB7 SKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCAS--LYGHSLTDRMVCAGYLDGKV ...: .::::. . . . ..:: ..: :.. :: : .:. .:: ::.:::::::.. NP_001 GSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYLDGRA 330 340 350 360 370 380 390 400 410 420 430 pF1KB7 DSCQGDSGGPLVCEEPSGRFF-LAGIVSWGIGCAEARRPGVYARVTRLRDWILEATTKAS :.::::::::::: :.: . :.:.:::: :::: .:::::.:... ::: NP_001 DACQGDSGGPLVC--PDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAEFLDWIHDTAQDSL 390 400 410 420 430 440 440 450 460 470 480 490 pF1KB7 MPLAPTMAPAPAAPSTAWPTSPESPVVSTPTKSMQALSTVPLDWVTVPKLQECGARPAME NP_001 L >>NP_110397 (OMIM: 606751) transmembrane protease serine (457 aa) initn: 848 init1: 230 opt: 766 Z-score: 626.8 bits: 126.4 E(85289): 3.6e-28 Smith-Waterman score: 766; 43.5% identity (73.3% similar) in 262 aa overlap (177-431:193-448) 150 160 170 180 190 200 pF1KB7 RDFKSGRCPGNSFSCGNSQCVTKVNPECDDQEDCSDGSDEA-HC-ECGLQPAWRMAGRIV ...:..:. . .: ::: .: .:.::: NP_110 NLTDIKLNSSQEFAQLSPRLGGFLEEAWQPRNNCTSGQVVSLRCSECGARP---LASRIV 170 180 190 200 210 210 220 230 240 250 260 pF1KB7 GGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCFNEFQDP--TKWVAYVGATY ::. ..::..:::::. . .: ::.... ::.:.::::.. :. ..: ...: . NP_110 GGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAGLVS 220 230 240 250 260 270 270 280 290 300 310 320 pF1KB7 LSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRHIQPVCLPAATHIFPP :. . : : .:. ::::.:.. :.:::.:.: . : :. . ::::: . :: NP_110 HSAVRPHQ-GALVERIIPHPLYSAQNHDYDVALLRLQTALNFSDTVGAVCLPAKEQHFPK 280 290 300 310 320 330 330 340 350 360 370 380 pF1KB7 SKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCAS--LYGHSLTDRMVCAGYLDGKV ...: .::::. . . . ..:: ..: :.. :: : .:. .:: ::.:::::::.. NP_110 GSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYLDGRA 340 350 360 370 380 390 390 400 410 420 430 pF1KB7 DSCQGDSGGPLVCEEPSGRFF-LAGIVSWGIGCAEARRPGVYARVTRLRDWILEATTKAS :.::::::::::: :.: . :.:.:::: :::: .:::::.:... ::: NP_110 DACQGDSGGPLVC--PDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAEFLDWIHDTAQDSL 400 410 420 430 440 450 440 450 460 470 480 490 pF1KB7 MPLAPTMAPAPAAPSTAWPTSPESPVVSTPTKSMQALSTVPLDWVTVPKLQECGARPAME NP_110 L 1059 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 08:33:52 2016 done: Sat Nov 5 08:33:54 2016 Total Scan time: 15.580 Total Display time: 0.220 Function used was FASTA [36.3.4 Apr, 2011]