Result of FASTA (omim) for
pF1KB7325
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7325, 1649 aa
1>>>pF1KB7325 1649 - 1649 aa - 1649 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 13.1836+/-0.000627; mu= -11.2101+/- 0.039
mean_var=821.2858+/-183.127, 0's: 0 Z-trim(117.6): 62 B-trim: 0 in 0/53
Lambda= 0.044754
statistics sampled from 29661 (29710) to 29661 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.673), E-opt: 0.2 (0.348), width: 16
Scan time: 19.300
The best scores are: opt bits E(85289)
NP_001013725 (OMIM: 234810,609280) eIF-2-alpha kin (1649) 10902 722.0 1e-206
XP_005254449 (OMIM: 234810,609280) PREDICTED: eIF- (1626) 10316 684.2 2.5e-195
XP_011519901 (OMIM: 234810,609280) PREDICTED: eIF- (1611) 10303 683.4 4.4e-195
XP_016877708 (OMIM: 234810,609280) PREDICTED: eIF- (1554) 8405 560.8 3.4e-158
XP_011519902 (OMIM: 234810,609280) PREDICTED: eIF- (1592) 8405 560.8 3.4e-158
NP_001276023 (OMIM: 142810,614504,616625) histidin ( 480) 525 51.3 2.4e-05
NP_002100 (OMIM: 142810,614504,616625) histidine-- ( 509) 525 51.3 2.5e-05
NP_001244969 (OMIM: 142810,614504,616625) histidin ( 469) 454 46.7 0.00057
NP_036340 (OMIM: 600783,614926) probable histidine ( 506) 445 46.2 0.00089
XP_016864778 (OMIM: 600783,614926) PREDICTED: prob ( 436) 443 46.0 0.00089
XP_016864777 (OMIM: 600783,614926) PREDICTED: prob ( 436) 443 46.0 0.00089
XP_011535921 (OMIM: 600783,614926) PREDICTED: prob ( 512) 445 46.2 0.0009
NP_001265660 (OMIM: 600783,614926) probable histid ( 481) 443 46.0 0.00095
>>NP_001013725 (OMIM: 234810,609280) eIF-2-alpha kinase (1649 aa)
initn: 10902 init1: 10902 opt: 10902 Z-score: 3832.2 bits: 722.0 E(85289): 1e-206
Smith-Waterman score: 10902; 100.0% identity (100.0% similar) in 1649 aa overlap (1-1649:1-1649)
10 20 30 40 50 60
pF1KB7 MAGGRGAPGRGRDEPPESYPQRQDHELQALEAIYGADFQDLRPDACGPVKEPPEINLVLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAGGRGAPGRGRDEPPESYPQRQDHELQALEAIYGADFQDLRPDACGPVKEPPEINLVLY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 PQGLTGEEVYVKVDLRVKCPPTYPDVVPEIELKNAKGLSNESVNLLKSRLEELAKKHCGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQGLTGEEVYVKVDLRVKCPPTYPDVVPEIELKNAKGLSNESVNLLKSRLEELAKKHCGE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 VMIFELAYHVQSFLSEHNKPPPKSFHEEMLERRAQEEQQRLLEAKRKEEQEQREILHEIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VMIFELAYHVQSFLSEHNKPPPKSFHEEMLERRAQEEQQRLLEAKRKEEQEQREILHEIQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 RRKEEIKEEKKRKEMAKQERLEIASLSNQDHTSKKDPGGHRTAAILHGGSPDFVGNGKHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRKEEIKEEKKRKEMAKQERLEIASLSNQDHTSKKDPGGHRTAAILHGGSPDFVGNGKHR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 ANSSGRSRRERQYSVCNSEDSPGSCEILYFNMGSPDQLMVHKGKCIGSDEQLGKLVYNAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANSSGRSRRERQYSVCNSEDSPGSCEILYFNMGSPDQLMVHKGKCIGSDEQLGKLVYNAL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 ETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 YLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB7 VVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDNALPYKTGKKGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDNALPYKTGKKGD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB7 VWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFIN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB7 PQPKMPLVEQSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQPKMPLVEQSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB7 FGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRYYNAWIERHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRYYNAWIERHE
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB7 RPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSAS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB7 ARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNEK
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB7 NGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIH
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB7 EKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB7 MVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSP
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB7 KFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHTLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHTLT
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB7 NVDGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NVDGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGA
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB7 VQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIE
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KB7 RVFRPRKLDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RVFRPRKLDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYL
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KB7 NHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKF
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KB7 IEQKGDLQDLMPTINSLIKQKTGIAQLVKYGLKDLEEVVGLLKKLGIKLQVLINLGLVYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IEQKGDLQDLMPTINSLIKQKTGIAQLVKYGLKDLEEVVGLLKKLGIKLQVLINLGLVYK
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KB7 VQQHNGIIFQFVAFIKRRQRAVPEILAAGGRYDLLIPQFRGPQALGPVPTAIGVSIAIDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VQQHNGIIFQFVAFIKRRQRAVPEILAAGGRYDLLIPQFRGPQALGPVPTAIGVSIAIDK
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KB7 ISAAVLNMEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISAAVLNMEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQ
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KB7 EYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLETELVDHVLQKLRTKVTDERNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLETELVDHVLQKLRTKVTDERNG
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KB7 REASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSASTRRRYETQVQTRLQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 REASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSASTRRRYETQVQTRLQT
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KB7 SLANLHQKSSEIEILAVDLPKETILQFLSLEWDADEQAFNTTVKQLLSRLPKQRYLKLVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLANLHQKSSEIEILAVDLPKETILQFLSLEWDADEQAFNTTVKQLLSRLPKQRYLKLVC
1570 1580 1590 1600 1610 1620
1630 1640
pF1KB7 DEIYNIKVEKKVSVLFLYSYRDDYYRILF
:::::::::::::::::::::::::::::
NP_001 DEIYNIKVEKKVSVLFLYSYRDDYYRILF
1630 1640
>>XP_005254449 (OMIM: 234810,609280) PREDICTED: eIF-2-al (1626 aa)
initn: 10301 init1: 10301 opt: 10316 Z-score: 3627.8 bits: 684.2 E(85289): 2.5e-195
Smith-Waterman score: 10713; 98.6% identity (98.6% similar) in 1649 aa overlap (1-1649:1-1626)
10 20 30 40 50 60
pF1KB7 MAGGRGAPGRGRDEPPESYPQRQDHELQALEAIYGADFQDLRPDACGPVKEPPEINLVLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MAGGRGAPGRGRDEPPESYPQRQDHELQALEAIYGADFQDLRPDACGPVKEPPEINLVLY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 PQGLTGEEVYVKVDLRVKCPPTYPDVVPEIELKNAKGLSNESVNLLKSRLEELAKKHCGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PQGLTGEEVYVKVDLRVKCPPTYPDVVPEIELKNAKGLSNESVNLLKSRLEELAKKHCGE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 VMIFELAYHVQSFLSEHNKPPPKSFHEEMLERRAQEEQQRLLEAKRKEEQEQREILHEIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VMIFELAYHVQSFLSEHNKPPPKSFHEEMLERRAQEEQQRLLEAKRKEEQEQREILHEIQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 RRKEEIKEEKKRKEMAKQERLEIASLSNQDHTSKKDPGGHRTAAILHGGSPDFVGNGKHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RRKEEIKEEKKRKEMAKQERLEIASLSNQDHTSKKDPGGHRTAAILHGGSPDFVGNGKHR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 ANSSGRSRRERQYSVCNSEDSPGSCEILYFNMGSPDQLMVHKGKCIGSDEQLGKLVYNAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ANSSGRSRRERQYSVCNSEDSPGSCEILYFNMGSPDQLMVHKGKCIGSDEQLGKLVYNAL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 ETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 YLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB7 VVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDNALPYKTGKKGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDNALPYKTGKKGD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB7 VWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFIN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB7 PQPKMPLVEQSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PQPKMPLVEQSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB7 FGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRYYNAWIERHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRYYNAWIERHE
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB7 RPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSAS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB7 ARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNEK
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB7 NGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIH
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB7 EKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB7 MVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSP
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB7 KFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHTLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHTLT
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB7 NVDGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NVDGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGA
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB7 VQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIE
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KB7 RVFRPRKLDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RVFRPRKLDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYL
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KB7 NHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKF
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KB7 IEQKGDLQDLMPTINSLIKQKTGIAQLVKYGLKDLEEVVGLLKKLGIKLQVLINLGLVYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IEQKGDLQDLMPTINSLIKQKTGIAQLVKYGLKDLEEVVGLLKKLGIKLQVLINLGLVYK
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KB7 VQQHNGIIFQFVAFIKRRQRAVPEILAAGGRYDLLIPQFRGPQALGPVPTAIGVSIAIDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VQQHNGIIFQFVAFIKRRQRAVPEILAAGGRYDLLIPQFRGPQALGPVPTAIGVSIAIDK
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KB7 ISAAVLNMEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ISAAVLNMEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQ
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KB7 EYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLETELVDHVLQKLRTKVTDERNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLETELVDHVLQKLRTKVTDERNG
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KB7 REASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSASTRRRYETQVQTRLQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 REASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSASTRRRYETQV------
1510 1520 1530 1540 1550
1570 1580 1590 1600 1610 1620
pF1KB7 SLANLHQKSSEIEILAVDLPKETILQFLSLEWDADEQAFNTTVKQLLSRLPKQRYLKLVC
:::::::::::::::::::::::::::::::::::::::::::
XP_005 -----------------DLPKETILQFLSLEWDADEQAFNTTVKQLLSRLPKQRYLKLVC
1560 1570 1580 1590
1630 1640
pF1KB7 DEIYNIKVEKKVSVLFLYSYRDDYYRILF
:::::::::::::::::::::::::::::
XP_005 DEIYNIKVEKKVSVLFLYSYRDDYYRILF
1600 1610 1620
>>XP_011519901 (OMIM: 234810,609280) PREDICTED: eIF-2-al (1611 aa)
initn: 10296 init1: 10296 opt: 10303 Z-score: 3623.3 bits: 683.4 E(85289): 4.4e-195
Smith-Waterman score: 10592; 97.7% identity (97.7% similar) in 1649 aa overlap (1-1649:1-1611)
10 20 30 40 50 60
pF1KB7 MAGGRGAPGRGRDEPPESYPQRQDHELQALEAIYGADFQDLRPDACGPVKEPPEINLVLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAGGRGAPGRGRDEPPESYPQRQDHELQALEAIYGADFQDLRPDACGPVKEPPEINLVLY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 PQGLTGEEVYVKVDLRVKCPPTYPDVVPEIELKNAKGLSNESVNLLKSRLEELAKKHCGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PQGLTGEEVYVKVDLRVKCPPTYPDVVPEIELKNAKGLSNESVNLLKSRLEELAKKHCGE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 VMIFELAYHVQSFLSEHNKPPPKSFHEEMLERRAQEEQQRLLEAKRKEEQEQREILHEIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VMIFELAYHVQSFLSEHNKPPPKSFHEEMLERRAQEEQQRLLEAKRKEEQEQREILHEIQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 RRKEEIKEEKKRKEMAKQERLEIASLSNQDHTSKKDPGGHRTAAILHGGSPDFVGNGKHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRKEEIKEEKKRKEMAKQERLEIASLSNQDHTSKKDPGGHRTAAILHGGSPDFVGNGKHR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 ANSSGRSRRERQYSVCNSEDSPGSCEILYFNMGSPDQLMVHKGKCIGSDEQLGKLVYNAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ANSSGRSRRERQYSVCNSEDSPGSCEILYFNMGSPDQLMVHKGKCIGSDEQLGKLVYNAL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 ETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 YLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB7 VVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDNALPYKTGKKGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDNALPYKTGKKGD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB7 VWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFIN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB7 PQPKMPLVEQSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PQPKMPLVEQSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB7 FGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRYYNAWIERHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRYYNAWIERHE
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB7 RPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSAS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB7 ARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNEK
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB7 NGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIH
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB7 EKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB7 MVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSP
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB7 KFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHTLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHTLT
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB7 NVDGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVDGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGA
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB7 VQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIE
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KB7 RVFRPRKLDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RVFRPRKLDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYL
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KB7 NHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKF
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KB7 IEQKGDLQDLMPTINSLIKQKTGIAQLVKYGLKDLEEVVGLLKKLGIKLQVLINLGLVYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IEQKGDLQDLMPTINSLIKQKTGIAQLVKYGLKDLEEVVGLLKKLGIKLQVLINLGLVYK
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KB7 VQQHNGIIFQFVAFIKRRQRAVPEILAAGGRYDLLIPQFRGPQALGPVPTAIGVSIAIDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VQQHNGIIFQFVAFIKRRQRAVPEILAAGGRYDLLIPQFRGPQALGPVPTAIGVSIAIDK
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KB7 ISAAVLNMEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ISAAVLNMEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQ
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KB7 EYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLETELVDHVLQKLRTKVTDERNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLETELVDHVLQKLRTKVTDERNG
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KB7 REASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSASTRRRYETQVQTRLQT
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 REASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSASTRRRYETQ-------
1510 1520 1530 1540 1550
1570 1580 1590 1600 1610 1620
pF1KB7 SLANLHQKSSEIEILAVDLPKETILQFLSLEWDADEQAFNTTVKQLLSRLPKQRYLKLVC
:::::::::::::::::::::::::::::
XP_011 -------------------------------WDADEQAFNTTVKQLLSRLPKQRYLKLVC
1560 1570 1580
1630 1640
pF1KB7 DEIYNIKVEKKVSVLFLYSYRDDYYRILF
:::::::::::::::::::::::::::::
XP_011 DEIYNIKVEKKVSVLFLYSYRDDYYRILF
1590 1600 1610
>>XP_016877708 (OMIM: 234810,609280) PREDICTED: eIF-2-al (1554 aa)
initn: 8771 init1: 8401 opt: 8405 Z-score: 2961.2 bits: 560.8 E(85289): 3.4e-158
Smith-Waterman score: 10109; 94.2% identity (94.2% similar) in 1649 aa overlap (1-1649:1-1554)
10 20 30 40 50 60
pF1KB7 MAGGRGAPGRGRDEPPESYPQRQDHELQALEAIYGADFQDLRPDACGPVKEPPEINLVLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAGGRGAPGRGRDEPPESYPQRQDHELQALEAIYGADFQDLRPDACGPVKEPPEINLVLY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 PQGLTGEEVYVKVDLRVKCPPTYPDVVPEIELKNAKGLSNESVNLLKSRLEELAKKHCGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQGLTGEEVYVKVDLRVKCPPTYPDVVPEIELKNAKGLSNESVNLLKSRLEELAKKHCGE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 VMIFELAYHVQSFLSEHNKPPPKSFHEEMLERRAQEEQQRLLEAKRKEEQEQREILHEIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VMIFELAYHVQSFLSEHNKPPPKSFHEEMLERRAQEEQQRLLEAKRKEEQEQREILHEIQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 RRKEEIKEEKKRKEMAKQERLEIASLSNQDHTSKKDPGGHRTAAILHGGSPDFVGNGKHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRKEEIKEEKKRKEMAKQERLEIASLSNQDHTSKKDPGGHRTAAILHGGSPDFVGNGKHR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 ANSSGRSRRERQYSVCNSEDSPGSCEILYFNMGSPDQLMVHKGKCIGSDEQLGKLVYNAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ANSSGRSRRERQYSVCNSEDSPGSCEILYFNMGSPDQLMVHKGKCIGSDEQLGKLVYNAL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 ETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 YLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB7 VVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDNALPYKTGKKGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDNALPYKTGKKGD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB7 VWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFIN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB7 PQPKMPLVEQSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQPKMPLVEQSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB7 FGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRYYNAWIERHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRYYNAWIERHE
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB7 RPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSAS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB7 ARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNEK
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB7 NGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIH
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB7 EKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB7 MVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSP
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB7 KFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHTLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHTLT
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB7 NVDGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NVDGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGA
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB7 VQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIE
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KB7 RVFRPRKLDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RVFRPRKLDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYL
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KB7 NHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKF
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLSLSSNS-------
1210 1220 1230 1240 1250
1270 1280 1290 1300 1310 1320
pF1KB7 IEQKGDLQDLMPTINSLIKQKTGIAQLVKYGLKDLEEVVGLLKKLGIKLQVLINLGLVYK
::::::::::
XP_016 --------------------------------------------------VLINLGLVYK
1260
1330 1340 1350 1360 1370 1380
pF1KB7 VQQHNGIIFQFVAFIKRRQRAVPEILAAGGRYDLLIPQFRGPQALGPVPTAIGVSIAIDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VQQHNGIIFQFVAFIKRRQRAVPEILAAGGRYDLLIPQFRGPQALGPVPTAIGVSIAIDK
1270 1280 1290 1300 1310 1320
1390 1400 1410 1420 1430 1440
pF1KB7 ISAAVLNMEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ISAAVLNMEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQ
1330 1340 1350 1360 1370 1380
1450 1460 1470 1480 1490 1500
pF1KB7 EYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLETELVDHVLQKLRTKVTDERNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLETELVDHVLQKLRTKVTDERNG
1390 1400 1410 1420 1430 1440
1510 1520 1530 1540 1550 1560
pF1KB7 REASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSASTRRRYETQVQTRLQT
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 REASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSASTRRRYETQ-------
1450 1460 1470 1480 1490
1570 1580 1590 1600 1610 1620
pF1KB7 SLANLHQKSSEIEILAVDLPKETILQFLSLEWDADEQAFNTTVKQLLSRLPKQRYLKLVC
:::::::::::::::::::::::::::::
XP_016 -------------------------------WDADEQAFNTTVKQLLSRLPKQRYLKLVC
1500 1510 1520
1630 1640
pF1KB7 DEIYNIKVEKKVSVLFLYSYRDDYYRILF
:::::::::::::::::::::::::::::
XP_016 DEIYNIKVEKKVSVLFLYSYRDDYYRILF
1530 1540 1550
>>XP_011519902 (OMIM: 234810,609280) PREDICTED: eIF-2-al (1592 aa)
initn: 8401 init1: 8401 opt: 8405 Z-score: 2961.1 bits: 560.8 E(85289): 3.4e-158
Smith-Waterman score: 10419; 96.5% identity (96.5% similar) in 1649 aa overlap (1-1649:1-1592)
10 20 30 40 50 60
pF1KB7 MAGGRGAPGRGRDEPPESYPQRQDHELQALEAIYGADFQDLRPDACGPVKEPPEINLVLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAGGRGAPGRGRDEPPESYPQRQDHELQALEAIYGADFQDLRPDACGPVKEPPEINLVLY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 PQGLTGEEVYVKVDLRVKCPPTYPDVVPEIELKNAKGLSNESVNLLKSRLEELAKKHCGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PQGLTGEEVYVKVDLRVKCPPTYPDVVPEIELKNAKGLSNESVNLLKSRLEELAKKHCGE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 VMIFELAYHVQSFLSEHNKPPPKSFHEEMLERRAQEEQQRLLEAKRKEEQEQREILHEIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VMIFELAYHVQSFLSEHNKPPPKSFHEEMLERRAQEEQQRLLEAKRKEEQEQREILHEIQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 RRKEEIKEEKKRKEMAKQERLEIASLSNQDHTSKKDPGGHRTAAILHGGSPDFVGNGKHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRKEEIKEEKKRKEMAKQERLEIASLSNQDHTSKKDPGGHRTAAILHGGSPDFVGNGKHR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 ANSSGRSRRERQYSVCNSEDSPGSCEILYFNMGSPDQLMVHKGKCIGSDEQLGKLVYNAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ANSSGRSRRERQYSVCNSEDSPGSCEILYFNMGSPDQLMVHKGKCIGSDEQLGKLVYNAL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 ETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETATGGFVLLYEWVLQWQKKMGPFLTSQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 YLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YLAMNLKEQDDSIVVDILVEHISGVSLAAHLSHSGPIPVHQLRRYTAQLLSGLDYLHSNS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB7 VVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDNALPYKTGKKGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVHKVLSASNVLVDAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDNALPYKTGKKGD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB7 VWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQQLLKHSFIN
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB7 PQPKMPLVEQSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PQPKMPLVEQSPEDSEGQDYVETVIPSNRLPSAAFFSETQRQFSRYFIEFEELQLLGKGA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB7 FGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRYYNAWIERHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLLSRLHHENIVRYYNAWIERHE
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB7 RPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAAPPPILSSSVEWSTSGERSAS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB7 ARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ARFPATGPGSSDDEDDDEDEHGGVFSQSFLPASDSESDIIFDNEDENSKSQNQDEDCNEK
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB7 NGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIH
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB7 EKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTG
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB7 MVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSP
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB7 KFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHTLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHTLT
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB7 NVDGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVDGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGA
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB7 VQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIE
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KB7 RVFRPRKLDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RVFRPRKLDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYL
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KB7 NHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKF
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLSLSSNS-------
1210 1220 1230 1240 1250
1270 1280 1290 1300 1310 1320
pF1KB7 IEQKGDLQDLMPTINSLIKQKTGIAQLVKYGLKDLEEVVGLLKKLGIKLQVLINLGLVYK
::::::::::
XP_011 --------------------------------------------------VLINLGLVYK
1260
1330 1340 1350 1360 1370 1380
pF1KB7 VQQHNGIIFQFVAFIKRRQRAVPEILAAGGRYDLLIPQFRGPQALGPVPTAIGVSIAIDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VQQHNGIIFQFVAFIKRRQRAVPEILAAGGRYDLLIPQFRGPQALGPVPTAIGVSIAIDK
1270 1280 1290 1300 1310 1320
1390 1400 1410 1420 1430 1440
pF1KB7 ISAAVLNMEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ISAAVLNMEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYDWSQSQEELQ
1330 1340 1350 1360 1370 1380
1450 1460 1470 1480 1490 1500
pF1KB7 EYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLETELVDHVLQKLRTKVTDERNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EYCRHHEITYVALVSDKEGSHVKVKSFEKERQTEKRVLETELVDHVLQKLRTKVTDERNG
1390 1400 1410 1420 1430 1440
1510 1520 1530 1540 1550 1560
pF1KB7 REASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSASTRRRYETQVQTRLQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 REASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSASTRRRYETQVQTRLQT
1450 1460 1470 1480 1490 1500
1570 1580 1590 1600 1610 1620
pF1KB7 SLANLHQKSSEIEILAVDLPKETILQFLSLEWDADEQAFNTTVKQLLSRLPKQRYLKLVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLANLHQKSSEIEILAVDLPKETILQFLSLEWDADEQAFNTTVKQLLSRLPKQRYLKLVC
1510 1520 1530 1540 1550 1560
1630 1640
pF1KB7 DEIYNIKVEKKVSVLFLYSYRDDYYRILF
:::::::::::::::::::::::::::::
XP_011 DEIYNIKVEKKVSVLFLYSYRDDYYRILF
1570 1580 1590
>>NP_001276023 (OMIM: 142810,614504,616625) histidine--t (480 aa)
initn: 363 init1: 139 opt: 525 Z-score: 216.9 bits: 51.3 E(85289): 2.4e-05
Smith-Waterman score: 525; 26.4% identity (63.4% similar) in 454 aa overlap (1055-1489:35-472)
1030 1040 1050 1060 1070 1080
pF1KB7 KAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGAVQLC
..: : ....: ..::: :::::: .
NP_001 EVAKLLKLKAQLGPDESKQKFVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVID
10 20 30 40 50 60
1090 1100 1110 1120 1130 1140
pF1KB7 TPLLLPRNRQIYEHNEAALFM----DHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIE
::.. .. . ...: . .. :..: :. : .:: .:::::.: :.. :.::: :
NP_001 TPVFELKETLMGKYGEDSKLIYDLKDQGGELLSLRYDLTVPFARYLAMNKLTNIKRYHIA
70 80 90 100 110 120
1150 1160 1170 1180 1190
pF1KB7 RVFRPRK--LDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSI
.:.: . . : . .:. .: :::. .. . ..: :: . . ::.. .:: .. .
NP_001 KVYRRDNPAMTRGRYREFYQCDFDIA-GNFDPMIPDAECLKIMCEILS---SLQIGDFLV
130 140 150 160 170 180
1200 1210 1220 1230 1240 1250
pF1KB7 YLNHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLS-LSSNSLCRL
.: .: ... ::. ..:. . . : . .:.. .::. .. . . :. . :.
NP_001 KVNDRRILDGMFAICGVSDSKFRTICSSV-DKL-DKVSWEEVKNEMVGEKGLAPEVADRI
190 200 210 220 230
1260 1270 1280 1290 1300 1310
pF1KB7 YKFIEQKGDLQDLMPTINSLIKQ-KTGIAQLVKYGLKDLEEVVGLLKKLGIKLQVLINLG
...:.: .. ...:... : . . . :: ::. . : .:: .. ..:.
NP_001 GDYVQQHGGVS----LVEQLLQDPKLSQNKQALEGLGDLKLLFEYLTLFGIDDKISFDLS
240 250 260 270 280 290
1320 1330 1340 1350 1360 1370
pF1KB7 LVYKVQQHNGIIFQFVAFIKRRQRAVPEIL-----AAGGRYDLLIPQFRGPQALGPVPTA
:. .. ..:.:.. : ... .: : : ::::::: :. .: :.. ::
NP_001 LARGLDYYTGVIYEAV-LLQTPAQAGEEPLGVGSVAAGGRYDGLVGMF-DPKGR-KVPC-
300 310 320 330 340 350
1380 1390 1400 1410 1420
pF1KB7 IGVSIAIDKISAAVLN----MEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAE
.:.::....: . : . .::.. . ..::.:. . . . ..:...:: ::: ::
NP_001 VGLSIGVERIFSIVEQRLEALEEKIRTTETQVLVASAQKKLLEERLKLVSELWDAGIKAE
360 370 380 390 400 410
1430 1440 1450 1460 1470 1480
pF1KB7 IMYDWSQSQEELQEYCRHHEITYVALVSDKEGSH--VKVKSFEKERQTEKRVLETELVDH
..: . . . .::.. : ::.....: . .:..: ...... : . .::..
NP_001 LLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRSVTSREEVDVR--REDLVEE
420 430 440 450 460
1490 1500 1510 1520 1530 1540
pF1KB7 VLQKLRTKVTDERNGREASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSAS
. ..
NP_001 IKRRTGQPLCIC
470 480
>>NP_002100 (OMIM: 142810,614504,616625) histidine--tRNA (509 aa)
initn: 363 init1: 139 opt: 525 Z-score: 216.7 bits: 51.3 E(85289): 2.5e-05
Smith-Waterman score: 525; 26.4% identity (63.4% similar) in 454 aa overlap (1055-1489:64-501)
1030 1040 1050 1060 1070 1080
pF1KB7 KAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGAVQLC
..: : ....: ..::: :::::: .
NP_002 EVAKLLKLKAQLGPDESKQKFVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVID
40 50 60 70 80 90
1090 1100 1110 1120 1130 1140
pF1KB7 TPLLLPRNRQIYEHNEAALFM----DHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIE
::.. .. . ...: . .. :..: :. : .:: .:::::.: :.. :.::: :
NP_002 TPVFELKETLMGKYGEDSKLIYDLKDQGGELLSLRYDLTVPFARYLAMNKLTNIKRYHIA
100 110 120 130 140 150
1150 1160 1170 1180 1190
pF1KB7 RVFRPRK--LDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSI
.:.: . . : . .:. .: :::. .. . ..: :: . . ::.. .:: .. .
NP_002 KVYRRDNPAMTRGRYREFYQCDFDIA-GNFDPMIPDAECLKIMCEILS---SLQIGDFLV
160 170 180 190 200
1200 1210 1220 1230 1240 1250
pF1KB7 YLNHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLS-LSSNSLCRL
.: .: ... ::. ..:. . . : . .:.. .::. .. . . :. . :.
NP_002 KVNDRRILDGMFAICGVSDSKFRTICSSV-DKL-DKVSWEEVKNEMVGEKGLAPEVADRI
210 220 230 240 250 260
1260 1270 1280 1290 1300 1310
pF1KB7 YKFIEQKGDLQDLMPTINSLIKQ-KTGIAQLVKYGLKDLEEVVGLLKKLGIKLQVLINLG
...:.: .. ...:... : . . . :: ::. . : .:: .. ..:.
NP_002 GDYVQQHGGVS----LVEQLLQDPKLSQNKQALEGLGDLKLLFEYLTLFGIDDKISFDLS
270 280 290 300 310 320
1320 1330 1340 1350 1360 1370
pF1KB7 LVYKVQQHNGIIFQFVAFIKRRQRAVPEIL-----AAGGRYDLLIPQFRGPQALGPVPTA
:. .. ..:.:.. : ... .: : : ::::::: :. .: :.. ::
NP_002 LARGLDYYTGVIYEAV-LLQTPAQAGEEPLGVGSVAAGGRYDGLVGMF-DPKGR-KVPC-
330 340 350 360 370
1380 1390 1400 1410 1420
pF1KB7 IGVSIAIDKISAAVLN----MEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAE
.:.::....: . : . .::.. . ..::.:. . . . ..:...:: ::: ::
NP_002 VGLSIGVERIFSIVEQRLEALEEKIRTTETQVLVASAQKKLLEERLKLVSELWDAGIKAE
380 390 400 410 420 430
1430 1440 1450 1460 1470 1480
pF1KB7 IMYDWSQSQEELQEYCRHHEITYVALVSDKEGSH--VKVKSFEKERQTEKRVLETELVDH
..: . . . .::.. : ::.....: . .:..: ...... : . .::..
NP_002 LLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRSVTSREEVDVR--REDLVEE
440 450 460 470 480 490
1490 1500 1510 1520 1530 1540
pF1KB7 VLQKLRTKVTDERNGREASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSAS
. ..
NP_002 IKRRTGQPLCIC
500
>>NP_001244969 (OMIM: 142810,614504,616625) histidine--t (469 aa)
initn: 312 init1: 141 opt: 454 Z-score: 192.3 bits: 46.7 E(85289): 0.00057
Smith-Waterman score: 454; 26.3% identity (63.4% similar) in 399 aa overlap (1106-1489:79-461)
1080 1090 1100 1110 1120 1130
pF1KB7 KRHGAVQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNILNLK
:..: :. : .:: .:::::.: :.. :.:
NP_001 ESKQKFVLKTPKETLMGKYGEDSKLIYDLKDQGGELLSLRYDLTVPFARYLAMNKLTNIK
50 60 70 80 90 100
1140 1150 1160 1170 1180 1190
pF1KB7 RYCIERVFRPRK--LDRFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQE
:: : .:.: . . : . .:. .: :::. .. . ..: :: . . ::.. .::
NP_001 RYHIAKVYRRDNPAMTRGRYREFYQCDFDIA-GNFDPMIPDAECLKIMCEILS---SLQI
110 120 130 140 150 160
1200 1210 1220 1230 1240 1250
pF1KB7 RNYSIYLNHTMLLKAILLHCGIPEDKLSQVYIILYDAVTEKLTRREVEAKFCNLS-LSSN
.. . .: .: ... ::. ..:. . . : . .:.. .::. .. . . :. .
NP_001 GDFLVKVNDRRILDGMFAICGVSDSKFRTICSSV-DKL-DKVSWEEVKNEMVGEKGLAPE
170 180 190 200 210 220
1260 1270 1280 1290 1300 1310
pF1KB7 SLCRLYKFIEQKGDLQDLMPTINSLIKQ-KTGIAQLVKYGLKDLEEVVGLLKKLGIKLQV
:. ...:.: .. ...:... : . . . :: ::. . : .:: ..
NP_001 VADRIGDYVQQHGGVS----LVEQLLQDPKLSQNKQALEGLGDLKLLFEYLTLFGIDDKI
230 240 250 260 270
1320 1330 1340 1350 1360
pF1KB7 LINLGLVYKVQQHNGIIFQFVAFIKRRQRAVPEIL-----AAGGRYDLLIPQFRGPQALG
..:.:. .. ..:.:.. : ... .: : : ::::::: :. .: :..
NP_001 SFDLSLARGLDYYTGVIYEAV-LLQTPAQAGEEPLGVGSVAAGGRYDGLVGMF-DPKGR-
280 290 300 310 320 330
1370 1380 1390 1400 1410 1420
pF1KB7 PVPTAIGVSIAIDKISAAVLN----MEESVTISSCDLLVVSVGQMSMSRAINLTQKLWTA
:: .:.::....: . : . .::.. . ..::.:. . . . ..:...:: :
NP_001 KVPC-VGLSIGVERIFSIVEQRLEALEEKIRTTETQVLVASAQKKLLEERLKLVSELWDA
340 350 360 370 380 390
1430 1440 1450 1460 1470 1480
pF1KB7 GITAEIMYDWSQSQEELQEYCRHHEITYVALVSDKEGSH--VKVKSFEKERQTEKRVLET
:: ::..: . . . .::.. : ::.....: . .:..: ...... : .
NP_001 GIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRSVTSREEVDVR--RE
400 410 420 430 440 450
1490 1500 1510 1520 1530 1540
pF1KB7 ELVDHVLQKLRTKVTDERNGREASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPE
.::... ..
NP_001 DLVEEIKRRTGQPLCIC
460
>>NP_036340 (OMIM: 600783,614926) probable histidine--tR (506 aa)
initn: 309 init1: 104 opt: 445 Z-score: 188.8 bits: 46.2 E(85289): 0.00089
Smith-Waterman score: 445; 26.7% identity (59.3% similar) in 450 aa overlap (1053-1476:61-492)
1030 1040 1050 1060 1070 1080
pF1KB7 DGKAYRTMMAQIFSQRISPAIDYTYDSDILKGNFSIRTAKM--QQHVCETIIRIFKRHGA
::. .. .: .... . .: ::::::
NP_036 VRCQSQVAEAVLTSQLKAHQEKPNFIIKTPKGTRDLSPQHMVVREKILDLVISCFKRHGA
40 50 60 70 80 90
1090 1100 1110 1120 1130
pF1KB7 VQLCTPLLLPRNRQIYEHNEAALFM----DHSGMLVMLPFDLRIPFARYVARNNILNLKR
. :: . .. ...: . .: :..: :. : .:: .:::::.: :.. ..::
NP_036 KGMDTPAFELKETLTEKYGEDSGLMYDLKDQGGELLSLRYDLTVPFARYLAMNKVKKMKR
100 110 120 130 140 150
1140 1150 1160 1170 1180 1190
pF1KB7 YCIERVFR---PRKLD-RFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQ
: . .:.: : .. :. .:. .: :::. . . ..: :: . . ::.. .::
NP_036 YHVGKVWRRESPTIVQGRY--REFCQCDFDIA-GQFDPMIPDAECLKIMCEILS---GLQ
160 170 180 190 200
1200 1210 1220 1230 1240 1250
pF1KB7 ERNYSIYLNHTMLLKAILLHCGIPEDKLSQV--YIILYDAVTEKLTRREVEAKFCNLSLS
.. : .: .. ... ::.::.:. . : : .. : .:.:. .: .:.
NP_036 LGDFLIKVNDRRIVDGMFAVCGVPESKFRAICSSIDKLDKMAWKDVRHEMVVK---KGLA
210 220 230 240 250 260
1260 1270 1280 1290 1300
pF1KB7 SNSLCRLYKFIEQKG--DLQDLMPTINSLIKQKTGIAQLVKYGLKDLEEVVGLLKKLGIK
. :. ... .: .: . : : ..: .. :: ::. . : .::
NP_036 PEVADRIGDYVQCHGGVSLVEQMFQDPRLSQNKQALE-----GLGDLKLLFEYLTLFGIA
270 280 290 300 310
1310 1320 1330 1340 1350 1360
pF1KB7 LQVLINLGLVYKVQQHNGIIFQFVAFIKRRQRAVPEIL-----AAGGRYDLLIPQFRGPQ
.. ..:.:. .. ..:.:.. : ... .: : : ::::::: :. .: :.
NP_036 DKISFDLSLARGLDYYTGVIYEAV-LLQTPTQAGEEPLNVGSVAAGGRYDGLVGMF-DPK
320 330 340 350 360 370
1370 1380 1390 1400 1410
pF1KB7 ALGPVPTAIGVSIAIDKISAAVLN-ME---ESVTISSCDLLVVSVGQMSMSRAINLTQKL
. :: .:.::....: : . :. :.: . ...:.. . ... ..: .:
NP_036 G-HKVPC-VGLSIGVERIFYIVEQRMKTKGEKVRTTETQVFVATPQKNFLQERLKLIAEL
380 390 400 410 420 430
1420 1430 1440 1450 1460 1470
pF1KB7 WTAGITAEIMYDWSQSQEELQEYCRHHEITYVALVSDKEGSH--VKVKSFE-KERQTEKR
: .:: ::..: . . .::. : :......: .. .:..: .:. . ::
NP_036 WDSGIKAEMLYKNNPKLLTQLHYCESTGIPLVVIIGEQELKEGVIKIRSVASREEVAIKR
440 450 460 470 480 490
1480 1490 1500 1510 1520 1530
pF1KB7 VLETELVDHVLQKLRTKVTDERNGREASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSV
NP_036 ENFVAEIQKRLSES
500
>>XP_016864778 (OMIM: 600783,614926) PREDICTED: probable (436 aa)
initn: 309 init1: 104 opt: 443 Z-score: 188.8 bits: 46.0 E(85289): 0.00089
Smith-Waterman score: 443; 26.7% identity (59.6% similar) in 438 aa overlap (1063-1476:3-422)
1040 1050 1060 1070 1080 1090
pF1KB7 QIFSQRISPAIDYTYDSDILKGNFSIRTAKMQQHVCETIIRIFKRHGAVQLCTPLLLPRN
..... . .: :::::: . :: . ..
XP_016 MVVREKILDLVISCFKRHGAKGMDTPAFELKE
10 20 30
1100 1110 1120 1130 1140
pF1KB7 RQIYEHNEAALFM----DHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIERVFR---P
...: . .: :..: :. : .:: .:::::.: :.. ..::: . .:.: :
XP_016 TLTEKYGEDSGLMYDLKDQGGELLSLRYDLTVPFARYLAMNKVKKMKRYHVGKVWRRESP
40 50 60 70 80 90
1150 1160 1170 1180 1190 1200
pF1KB7 RKLD-RFHPKELLECAFDIVTSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYLNHTM
.. :. .:. .: :::. . . ..: :: . . ::.. .:: .. : .:
XP_016 TIVQGRY--REFCQCDFDIA-GQFDPMIPDAECLKIMCEILS---GLQLGDFLIKVNDRR
100 110 120 130 140
1210 1220 1230 1240 1250 1260
pF1KB7 LLKAILLHCGIPEDKLSQV--YIILYDAVTEKLTRREVEAKFCNLSLSSNSLCRLYKFIE
.. ... ::.::.:. . : : .. : .:.:. .: .:. . :. ...
XP_016 IVDGMFAVCGVPESKFRAICSSIDKLDKMAWKDVRHEMVVK---KGLAPEVADRIGDYVQ
150 160 170 180 190 200
1270 1280 1290 1300 1310 1320
pF1KB7 QKG--DLQDLMPTINSLIKQKTGIAQLVKYGLKDLEEVVGLLKKLGIKLQVLINLGLVYK
.: .: . : : ..: .. :: ::. . : .:: .. ..:.:.
XP_016 CHGGVSLVEQMFQDPRLSQNKQALE-----GLGDLKLLFEYLTLFGIADKISFDLSLARG
210 220 230 240 250
1330 1340 1350 1360 1370
pF1KB7 VQQHNGIIFQFVAFIKRRQRAVPEIL-----AAGGRYDLLIPQFRGPQALGPVPTAIGVS
.. ..:.:.. : ... .: : : ::::::: :. .: :.. :: .:.:
XP_016 LDYYTGVIYEAV-LLQTPTQAGEEPLNVGSVAAGGRYDGLVGMF-DPKG-HKVPC-VGLS
260 270 280 290 300 310
1380 1390 1400 1410 1420 1430
pF1KB7 IAIDKISAAVLN-ME---ESVTISSCDLLVVSVGQMSMSRAINLTQKLWTAGITAEIMYD
:....: : . :. :.: . ...:.. . ... ..: .:: .:: ::..:
XP_016 IGVERIFYIVEQRMKTKGEKVRTTETQVFVATPQKNFLQERLKLIAELWDSGIKAEMLYK
320 330 340 350 360 370
1440 1450 1460 1470 1480
pF1KB7 WSQSQEELQEYCRHHEITYVALVSDKEGSH--VKVKSFE-KERQTEKRVLETELVDHVLQ
. . .::. : :......: .. .:..: .:. . ::
XP_016 NNPKLLTQLHYCESTGIPLVVIIGEQELKEGVIKIRSVASREEVAIKRENFVAEIQKRLS
380 390 400 410 420 430
1490 1500 1510 1520 1530 1540
pF1KB7 KLRTKVTDERNGREASDNLAVQNLKGSFSNASGLFEIHGATVVPIVSVLAPEKLSASTRR
XP_016 ES
1649 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 02:43:02 2016 done: Sat Nov 5 02:43:05 2016
Total Scan time: 19.300 Total Display time: 0.750
Function used was FASTA [36.3.4 Apr, 2011]